Evolution of Feathers: Inspiration for Future Industrial Material Construction - iesResearch
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            [post_title] => Decoding the Nuclear Force in Nuclear Medium: Understanding Nucleon Effective Mass Splitting with Light Particle Emission
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            [post_title] => Illuminating the Secrets of Nuclear Isomers with Cutting-Edge Laser-Wakefield Acceleration
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                            [researchers_name] => Xueqing Yan
                            [researchers_position] => State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, China
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                            [researchers_name_2] => Haoyang Lan
                            [researchers_position_2] => State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, China
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                    [original_article_reference] => 
                    [research_footprints] => Photonuclear reactions; Laser plasma acceleration; Flux-averaged isomer ratio
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The study unveils a cutting-edge method for investigating nuclear isomers through the use of laser-wakefield accelerated (LWFA) electrons in photonuclear measurements, leveraging the unique environments created by the interaction between laser and target. Drawing from theoretical calculations and Geant4 simulations, researchers discovered the potential of the LWFA electron beam and its bremsstrahlung for photonuclear studies involving nuclear isomers. The main findings reveal that a stable electron beam with an energy of 78–135 MeV and a charge of 300-600 pC can be obtained from the Compact Laser Plasma Accelerator (CLAPA) laboratory experiments, enabling a new way to explore nuclear isomers and their potential applications. Additionally, a bremsstrahlung source with a peak intensity of 1019 photons/s can be generated. This innovative approach holds significant promise for future advancements in the study of nuclear isomers and further developments in their real-world applications.

[the_background] =>

Nuclear isomers, which have been a subject of significant interest for over a century, are excited states of atomic nuclei with unique properties and potential applications. Despite their potential uses in nuclear clocks, nuclear batteries, and gamma lasers, previous research has faced limitations in the effective population and manipulation of nuclear isomers. Studying isomeric states in nuclear astrophysics can help us better understand the formation of elements in the universe and their role in the development of life. However, approaches to produce short-lived nuclear isomers are limited. This research addresses the knowledge gap by proposing a novel approach using laser-wakefield accelerated (LWFA) electrons for photonuclear measurements. The recent advancements in high intensity and high-repetition-rate laser systems have opened new research opportunities in this area, with laser-plasma interactions providing opportunities to overcome past limitations and explore the potential of nuclear isomers more effectively.

[the_sdg_impact] =>

According to the International Energy Agency (IEA), global energy demand is projected to increase by 50% by 2050. This research can potentially lead to the development of more efficient energy sources like nuclear batteries, support advances in nuclear astrophysics to better comprehend the universe, and promote further innovations in nuclear technology. Hence, this groundbreaking study on nuclear isomers using laser-wakefield accelerated (LWFA) electrons directly contributes to SDG 7, which focuses on ensuring affordable and clean energy, by offering potential advancements in nuclear energy applications. Furthermore, the study also supports SDG 9, which aims to build resilient infrastructure, promote inclusive and sustainable industrialization, and foster innovation.

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This research provides a comprehensive analysis of induced radioactivity in a carbon-ion radiotherapy (CIRT) treatment room, utilizing the Heavy-Ion Medical Machine (HIMM) in Wuwei as a case study. By employing Monte Carlo simulations with PHITS, the study evaluates the activation of air, phantom, and various components of the beamline, delivering valuable insights into radiation protection for medical staff and patients’ family. The main findings reveal that external radiation caused by air activation is the primary source of the annual effective dose at approximately 0.5 mSv/y, while induced radioactivity exposure to family members after CIRT remains low at around 40 μSv. These results offer guidance for assessing induced radioactivity levels in CIRT treatment rooms, as well as radiation protection recommendations for medical staff and equipment decommissioning. This novel approach paves the way for future improvements in safety and efficacy of CIRT.

[the_background] =>

Carbon-ion radiotherapy (CIRT) has emerged as a crucial tool in cancer treatment due to its superior physical and biological advantages compared to traditional photon radiotherapy. It is more destructive to the target volume while being less injurious to surrounding healthy tissues. However, concerns have been raised about the radiation protection for medical staff and patients in the treatment room, as high-energy therapeutic carbon-ion beams can cause materials and devices in the CIRT treatment room to become radioactive. Past studies have not comprehensively assessed the induced radioactivity in CIRT treatment rooms, leaving a knowledge gap in understanding its potential risks and impact on radiation protection. Hence, this study aimed to provide a more systematic investigation of the induced radioactivity in the treatment room for CIRT using the Monte Carlo (MC) method. The research outputs are valuable in helping medical professionals formulate protection measures, ensuring safety during radiotherapy and quality assurance.

[the_sdg_impact] =>

According to the World Health Organization, cancer is the second leading cause of death globally, with nearly 10 million deaths in 2020. As the prevalence of CIRT grows, it is crucial to address potential radiation hazards for medical staff and additional unwanted doses for patients to ensure safe and effective treatments. It supports SDG 3: Good Health and Well-being by providing insights into induced radioactivity in CIRT treatment rooms. Furthermore, the research contributes to SDG 9: Industry, Innovation, and Infrastructure by helping to optimize the operation of CIRT facilities, promoting technological advancements, and fostering innovation in cancer treatment methods.

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The Shanghai Laser Electron Gamma Source (SLEGS) time-of-flight (TOF) spectrometer was successfully developed and evaluated in this study as a groundbreaking tool for exploring photonuclear physics. This achievement allows precise measurement of giant dipole resonance (GDR). Using Geant4 simulations and offline experiments, the study found that the SLEGS TOF spectrometer excelled in distinguishing γ-rays and neutrons of GDR decay, with a time resolution of approximately 0.9 ns. Compared to the 3He counter tube, the ability of SLEGS TOF spectrometer to measure neutron energy leads to the precise measurement of nuclear energy level, energy level width, decay channel, branch ratio, angular distribution, differential cross section and more. The research output paves the way for further research and development of advanced tools for nuclear physics experimentation. The possible expansion of this research includes the potential for future discoveries in photonuclear physics and nuclear energy research.

[the_background] =>

The Shanghai Laser Electron Gamma Source (SLEGS) is a high-intensity γ-ray beamline that uses laser Compton scattering to study photonuclear reactions ranging from photon excitation to photon disintegration. Previous studies have been constrained by limitations in the construction and development of gamma sources, resulting in restricted measurements of giant dipole resonance (GDR) based on photon sources over the past 20 years. Meanwhile, efforts have been made in the past to measure photoneutron cross sections using 3He counter tubes. The total cross section data for photoneutron reactions has a large degree of disagreement and resolving this was expected to solve the difficulties in the synthesis of cosmic nucleosynthesis. However, the 3He counter tube could not carry out accurate measurement of neutron energy because of the moderation of neutrons by polyethylene. To address the existing limitations, this study developed the SLEGS time-of-flight (TOF) spectrometer, which can measure the γ-rays and neutron radiation emitted during the decay of nuclear collective states, specifically for the study of isovector giant dipole resonance (IVGDR). The successful development of SLEGS TOF spectrometer provides a reliable reference for the selection of detectors and the layout of the SLEGS TOF spectrometer. This will lead to major progress in the measurement of photon-neutron nuclear reactions and broaden our understanding of nuclear structures.

[the_sdg_impact] =>

The application of nuclear technology faces several challenges, including the safe disposal of nuclear waste, the potential for nuclear accidents, and concerns about nuclear weapons proliferation. This indicates the urgent need to advance research in nuclear physics and photonuclear reactions. The successful development and evaluation of the Shanghai Laser Electron Gamma Source (SLEGS) time-of-flight (TOF) spectrometer play important roles in contributing to the rapid advancement of nuclear science and technology (UNSDG 9).

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In this study, a novel rapid diagnostic method was developed for optimizing the production of transplutonium isotope through high flux reactor irradiation. The proposed method was based on the concept of "Single Energy Interval Value (SEIV)" and "Energy Spectrum Total Value (ESTV)", which significantly improved the production efficiency of isotopes such as 252Cf (by 15.08 times), 244Cm (by 65.20 times), 242Cm (by 11.98 times), and 238Pu (by 7.41 times). As a promising alternative to the traditional Monte Carlo burnup calculation method, this method offers a more efficient approach to evaluate radiation schemes and optimize the design parameters. The research discovery provides a theoretical basis for further refining the analysis of transplutonium isotope production, leading to more efficient and sustainable production methods. Future studies could focus on the implementation of energy spectrum conversion technology to further improve the optimal energy spectrum.

[the_background] =>

The production of transplutonium isotope, which are essential in numerous fields such as military and space technology, remains inefficient despite being produced through irradiation in a high flux reactor. Past studies on the optimization of transplutonium isotope production through irradiation in a high flux reactor have been limited by the computational complexity of traditional methods such as Monte Carlo burnup calculation. These limitations have hindered the refinement of the evaluation, screening, and optimization of the irradiation schemes. Hence, this research aimed to develop a rapid diagnostic method for evaluating radiation schemes that can improve the production efficiency of isotopes such as 252Cf, 244Cm, 242Cm, and 238Pu. The outcome of the study showed great potential in advancing the production of transplutonium isotope, which have numerous applications in fields such as military, energy, and space technology.

[the_sdg_impact] =>

The limited production rate of transplutonium isotopes poses a significant challenge in meeting the growing demand for sustaining the nuclear industry (i.e. energy and military). This research provides a sustainable solution to improve the efficiency of transplutonium isotope production through a novel rapid diagnostic method. Thus, it fulfils UNSDG 7 (Affordable and Clean Energy) by providing a sustainable source of energy, as well as UNSDG 9 (Industry, Innovation and Infrastructure) by promoting technological innovation in the nuclear industry, especially for military use.

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This study thoroughly proposed the design of Megahertz cavIty eNhanced x-ray Generation (MING) which was meant to be set up in China’s first hard X-ray free-electron laser (XFEL) facility i.e. SHINE. The proposal covers crucial topics like principles and performance of MING, key components of MING, as well as X-ray transport and diagnostics. MING will be equipped with an undulator of period 26 mm and crystal cavity, covering the energy range of 6–15 keV. Moreover, MING will be able to generate X-ray with pulse bandwidth of a few tens of meV, while the pulse energies can achieve 300 µJ, corresponding to the spectral brightness increased by 2-3 orders of magnitude. Besides producing high-intensity fully coherent X-rays, MING allows for full control of the polarization of X-rays and can also deliver orbital angular momentum (OAM) light, indicating its superb scalability. To-date, the first cavity-based XFEL facility is yet to be completed. Therefore, the proposal of MING would definitely broaden scientists’ horizon on cavity-based XFEL’s potential and applications, leading to groundbreaking discoveries.

[the_background] =>

X-ray free-electron laser (XFEL) is a new generation X-ray source which facilitates the rapid progress of multiple research areas. SHINE (China’s first hard XFEL facility), an 8 GeV high-repetition-rate XFEL facility equipped with a continuous-wave (CW) superconducting radio frequency linear accelerator (RF linac), was proposed to be set up in Shanghai in 2017 and estimated to be complete in 2025. Despite being foreseen to deliver brilliant, nearly fully transversely coherent, and ultra-short X-ray pulses, scientists are also aware of its low longitudinal coherence and poor stability. Although the self-seeding technique (for hard X-ray regime) could overcome the problems, high intensity jitter might take place because self-seeding schemes are based on self-amplified spontaneous emission (SASE). Nonetheless, since SHINE will be providing 8 GeV electron bunches at ∼ 1 MHz, it bears the potential to operate a cavity-based XFEL (e.g. XFELOs and RAFELs) which produces fully coherent laser-like X-ray pulses. In order to materialize that within the context of SHINE, this study planned and proposed the design of Megahertz cavIty enhanced X-ray generation (MING) for generating X-rays in the energy range of 6–15 keV. With the optimum design and parameters, MING was predicted to be the key to push the performance of SHINE to a new level.

[the_sdg_impact] =>

One of the ultimate goals of XFEL is to generate fully coherent pulses and the cavity-based FEL is a promising candidate to achieve this goal. Thus, cavity-based FELs could potentially bring tremendous advancement to various research fields including atomic and molecular science, photon science, and advanced materials. The realization of MING@SHINE will be a remarkable milestone in the evolution of XFELs and, hence, this study is well-aligned with UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-022-01151-6 [main_image] => https://iesresearch.solutions/wp-content/uploads/2023/04/MING-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2023/04/24781098_1682472440.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-01151-6 [original_article_reference_fields] => Array ( [publication_title] => The MING proposal at SHINE: megahertz cavity enhanced X-ray generation [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => January 2023 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/DMGsx8Aozv8 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2023/04/NST-11-w-sub-music-ver3.jpg ) ) [6] => WP_Post Object ( [ID] => 35393 [post_author] => 154 [post_date] => 2023-02-15 10:38:51 [post_date_gmt] => 2023-02-15 02:38:51 [post_content] => [post_title] => Accurate Prediction of Cross-section of Extremely Rare Isotope [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => accurate-prediction-of-cross-section-of-extremely-rare-isotope [to_ping] => [pinged] => [post_modified] => 2024-01-17 10:47:30 [post_modified_gmt] => 2024-01-17 02:47:30 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=35393 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MA, Chun Wang [researchers_position] => College of Physics, Henan Normal University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2023/02/Isotope.png [researchers_profile] => https://www.researchgate.net/profile/Chun-Wang-Ma [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Bayesian neural network (BNN); FRACS; Drip line; Extremely rare isotope; Projectile fragmentation [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2023/02/2022_NST_Article_10_v1-scaled.jpg [figures] => [video] => [the_novelty] =>

To pursue the exploration of drip line nuclides, this study performed multiple-models predictions to predict the cross-sections of extremely rare isotope (ERI) produced in typical projectile fragmentation (PF) reactions in the Facility for Rare Isotope Beam (FRIB), namely 78,86Kr + 9Be, 58,64Ni + 9Be, and 40,48Ca + 9Be reactions at 140 MeV/u. The multiple-models predictions comprised the EPAX3, FRACS, Bayesian neural network technology (BNN), and BNN + FRACS models. Results showed that both neutron and proton drip lines can be reached for elements of atomic number ≤ 11 with the lowest cross-section of 10−15 mb. The newly created most neutron-rich 39Na verifies the high precision of BNN prediction. Based on the promising results, future studies may apply the proposed methods to enhance the feasibility of creating a larger variety of ERIs in the newly commissioned FRIB factory, leading to more advanced experimental research.

[the_background] =>

Short-life, unstable, radioactive nuclei are exotic when they develop unusual structures. In order to facilitate the advancement of research, modern rare isotope beam (RIB) factories were set up to enhance the production of extremely rare isotopes (ERI) at or near drip lines. The ERI can be produced more effectively via a higher-level understanding on the projectile fragmentation reactions. As an effort to achieve that, this study performed multi-models predictions of cross-sections for ERIs in typical reactions using EPAX3, FRACS, BNN, and BNN + FRACS models, of which the BNN and BNN + FRACS models were newly developed massive learning models using Bayesian Neural Networks. The output of the study confirmed the feasibility to create a significantly large number of new isotopes in FRIB, leading to a richer knowledge base for nuclear structure, nuclear reaction, and nuclear astrophysics.

[the_sdg_impact] =>

The new rare isotope factories provide unique technology to extend the boundaries on the chart of nucleus in experiments. This study shows how far from the β-stability line the ERI can reach within the lowest detecting limitations in the newly commissioned FRIB in Michigan State University, USA. By supporting future research related to nuclear science, its output is very well-aligned with UNSDG 9: Industries, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-022-01137-4 [main_image] => https://iesresearch.solutions/wp-content/uploads/2023/02/Isotope2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2023/02/23031885_1676428476.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-01137-4 [original_article_reference_fields] => Array ( [publication_title] => Multiple-models predictions for drip line nuclides in projectile fragmentation of 40,48 Ca, 58,64 Ni, and 78,86 Kr at 140 MeV/u [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => December 2022 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/pi7YWX57xmU [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2023/02/NST-10-v2.mp4_snapshot_00.11_2023.02.15_10.41.28.jpg ) ) [7] => WP_Post Object ( [ID] => 35291 [post_author] => 154 [post_date] => 2023-01-16 10:56:19 [post_date_gmt] => 2023-01-16 02:56:19 [post_content] => [post_title] => Nanoscale Radiation Damage-Free Imaging by Coherent Scattering and Imaging Endstation [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => nanoscale-radiation-damage-free-imaging-by-coherent-scattering-and-imaging-endstation [to_ping] => [pinged] => [post_modified] => 2023-12-26 10:35:31 [post_modified_gmt] => 2023-12-26 02:35:31 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=35291 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => FAN, Jiadong [researchers_position] => The Center for Transformative Science, Shanghaitech University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2023/01/Radiation-.png [researchers_profile] => https://www.researchgate.net/profile/Jiadong_Fan2 [researchers_second_profile] => https://orcid.org/0000-0002-1188-4628 ) [researchers_info_2] => Array ( [researchers_name_2] => JIANG, Huaidong [researchers_position_2] => The Center for Transformative Science, Shanghaitech University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2023/01/Radiation-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Huaidong-Jiang [researchers_second_profile_2] => https://orcid.org/0000-0002-0895-1690 ) [original_article_reference] => [research_footprints] => X-ray free electron laser; Coherent diffraction imaging; Fourier transform holography; Single-shot imaging; Phase retrieval [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2023/01/2022_NST_Article_08_v2_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

This study presents the first commissioning results of the coherent scattering and imaging (CSI) endstation (first of five) at the Shanghai soft X-ray Free-Electron Laser (SXFEL). Nanoscale imaging was reconstructed successfully based on the single-shot holograms and coherent diffraction patterns recorded. During the test on gold nanocubes, the diffraction signals extended to the edge of the CCD detector attributing to the ultrahigh peak brilliance of the SXFEL. Besides that, the missing central area was lesser than the central speckle. The reconstructed image allowed accurate estimation of the edge length of the cubic particles. For gold nanospheres, clear interference speckles were observed and they indicated the presence of multiple nanosphere. Moreover, the test on mitochondria proved the high feasibility of the CSI endstation for “diffraction before destruction” experiments. High-contrast mitochondria structures could be observed (without sectioning) due to the penetration depth and unique imaging opportunities for high contrast in the “water window” energy range (wavelength between 4.40 to 2.33nm). Upon performing a fast Fourier transform of a gold film hologram, both the Fourier transform holography (FTH) image and the reconstructed image (using phase retrieval techniques) were consistent with the scanning electron microscope (SEM) results. Other than commissioning the remaining four endstations in year 2022, the cryogenic sample environment, aerosol sample injector, high-performance detector with a large dynamic range, and optical pump lasers will also be commissioned for in situ and time-resolved experiments at the CSI endstation.

[the_background] =>

X-ray-based microscopes have been used for high-resolution nanoscale imaging to study extremely fine structures. Following the progressive maturity of both coherent X-ray light sources and novel X-ray imaging methods, coherent diffraction imaging (CDI) (i.e. a novel lensless imaging method) has been developed to examine fine structures at nanoscale. Meanwhile, X-ray free-electron lasers (XFELs) are powerful X-ray sources which produce ultra-bright and highly coherent femtosecond pulses. Its advantages include spatial and temporal coherence as well as gigawatt peak power. Taking advantage of the excellent properties of XFEL and CDI, the single-shot diffraction patterns can be recorded with the femtosecond pulses before the radiation damage occurs. Thus, the radiation damage-free structures of samples can be achieved at nanoscale. The Shanghai Soft X-ray Free-Electron Laser Facility (SXFEL) is the first X-ray FEL facility in China. Built on the Shanghai Synchrotron Radiation Facility (SSRF) campus, its X-ray achieves an energy range of 100 – 620 eV while comprising 1.5 GeV linear accelerator, two undulator lines, two beamlines, and five endstations. In Phase 1, the SXFEL consists of 5 proposed endstations meant for different scopes of study, i.e. dynamic scattering and high spatial and temporal imaging, ultrafast physical phenomena, surface and ultrafast chemical processes, as well as atomic and molecular physics. The high temporal and spatial resolution falls under the role of coherent scattering and imaging (CSI) endstation. This study chose the CSI endstation as the first endstation to be commissioned. The successful commissioning of CSI endstation unvealed its high efficiency in high-resolution radiation damage-free imaging at nanoscale.

[the_sdg_impact] =>

Ultrafast high-resolution nanoscale imaging is an essential characterization technique for studies focusing on functional materials, biological cells, and organelles. The successful commissioning of CSI endstation of SXFEL and its future effort could significantly enhance the advancement of research of various fields. With easier access to the state-of-the-art facilities, limitless achievement can be realized within shorter time frame. Hence, the output of this study fulfils UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-022-01103-0 [main_image] => https://iesresearch.solutions/wp-content/uploads/2023/01/Radiation-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2023/01/22224085_1673837469.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-01103-0 [original_article_reference_fields] => Array ( [publication_title] => First commissioning results of the coherent scattering and imaging endstation at the Shanghai soft X-ray free-electron laser facility [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => September 2022 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/LrKU0gIZpyw [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2023/01/NST22-08-with-Chinese-sub.mp4_snapshot_00.00_2023.01.16_10.51.49.jpg ) ) [8] => WP_Post Object ( [ID] => 35257 [post_author] => 154 [post_date] => 2023-01-16 09:53:39 [post_date_gmt] => 2023-01-16 01:53:39 [post_content] => [post_title] => BHV Calcification Overcome by Two-Step Decellularization Strategy [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => bhv-calcification-overcome-by-two-step-decellularization-strategy [to_ping] => [pinged] => [post_modified] => 2023-11-21 13:49:35 [post_modified_gmt] => 2023-11-21 05:49:35 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=35257 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GAO, Caiyun [researchers_position] => Department of Macromolecular Science, Fudan University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2023/01/TSD-.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => WANG, Gang [researchers_position_2] => R&D Center, Lifevalve Medical Scientific Co., Ltd, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2023/01/TSD-2.png [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Heart valve; Anticalcification; Collagen; In vivo biomineralization; Transcatheter aortic valve implantation (TAVI); Extracellular matrix; Biomacromolecular network; Biosurfactant; Bovine pericardium [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2023/01/2022_CPP_Article_04_v1-1-scaled.jpg [figures] => [video] => [the_novelty] =>

This study revealed a two-step decellularization (TSD) strategy which effectively led to ultra-low in vivo calcification in bovine pericardial bioprosthetic heart valves (BHVs). After the traditional decellularization and glutaraldehyde (GA) cross-linking, the BHV was introduced to a second-step decellularization by employing a mild biosurfactant n-dodecyl-β-D-maltoside. In pre-clinical studies, the TSD strategy remarkably lowered the in vivo calcification from 138.6 to 1.1 μg/mg, while rendering low cytotoxicity and superior mechanical properties in vitro. Based on the outcome, future studies may explore the feasibility to improve the overall properties of bioprosthetic products by using similar types of mild biosurfactants.

[the_background] =>

Among the common artificial heart valves, bioprosthetic heart valves (BHVs) are preferred over mechanical heart valves for their impressive hemodynamic performance, independence of lifelong anticoagulation, and superior level of anti-infection. The commercial BHVs are usually made of either porcine pericardium (PP) or bovine pericardium (BP) treated by glutaraldehyde (GA). The BHVs’ main cause of failure is calcification which is very likely to be given rise by phospholipids in plasma membranes and intracellular membranes. To overcome calcification, past studies attempted to employ non-glutaraldehyde cross-linking agents and anticalcification treatments but the outcomes were not ideal. In order to pursue further, this study developed a two-step decellularization (TSD) strategy which involved the use of n-dodecyl-β-D-maltoside (DDM) in the mixture of isopropanol (IPA) and phosphate-buffered saline (PBS). The promising output verified the potential of the biosurfactant employed and, thus, created a new research avenue for improving and enhancing the existing interventional bioprosthetic products.

[the_sdg_impact] =>

In the US, there are 25,000 deaths each year due to heart valve disease. This alarming figure indicates that interventional bioprosthetic products with higher reliability will contribute to the longevity of humans. Hence, by developing effective strategies to enhance the performance and lifespan of BHV, this study shows a good alignment with UNSDG 3: Good Health & Well-being.

[article_url] => https://link.springer.com/article/10.1007/s10118-022-2843-9 [main_image] => https://iesresearch.solutions/wp-content/uploads/2023/01/TSD-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2023/01/22223168_1673833677.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s10118-022-2843-9 [original_article_reference_fields] => Array ( [publication_title] => A Biosurfactant-containing TSD Strategy to Modify Bovine Pericardial Bioprosthetic Valves for Anticalcification [journal_title] => Chinese Journal of Polymer Science [publisher] => Springer Nature [year] => September 2022 [subject] => Polymer Science; Medical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Dl3yr1_wVTQ [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2023/01/CPP-4.mp4_snapshot_00.00_2023.01.16_09.55.22.jpg ) ) [9] => WP_Post Object ( [ID] => 35210 [post_author] => 154 [post_date] => 2022-12-14 10:34:06 [post_date_gmt] => 2022-12-14 02:34:06 [post_content] => [post_title] => Impact of Chain Flexibility and Connectivity on Polymer Crystallization [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => impact-of-chain-flexibility-and-connectivity-on-polymer-crystallization [to_ping] => [pinged] => [post_modified] => 2023-11-21 13:51:24 [post_modified_gmt] => 2023-11-21 05:51:24 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=35210 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LI, Liangbin [researchers_position] => National Synchrotron Radiation Lab, University of Science and Technology of China, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/12/Polymer-.png [researchers_profile] => https://www.researchgate.net/profile/Liangbin-Li [researchers_second_profile] => https://orcid.org/0000-0002-1887-9856 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Polymer crystallization; Chain flexibility; Chain connectivity; Nucleation [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/12/2022_CPP_Article_05_v1-2-scaled.jpg [figures] => [video] => [the_novelty] =>

What are the fundamental features that determine the unique properties of polymers? This review thoroughly discussed the significance of chain flexibility and connectivity in the crystallization of polymers. With regards to chain flexibility, it has been verified that conformational ordering can occur before crystallization. This was assisted by a local interchain order such as bond-orientation order. Furthermore, the mechanism underlying the occurrence of conformational ordering without the assistance of crystal packing has been elucidated. Chain connectivity is crucial for the formation of semicrystalline lamellar stack structure and also for intrachain nucleation. Compared to crystallization of small molecules, polymer crystallization is harder due to chain entanglement which brings in entanglement pressure and leads to higher nucleation barrier. Meanwhile, the entanglement free energy has a major influence in determining crystallization behavior. Based on the review, the author proposed several potential directions to further pursue the investigation in chain flexibility and connectivity.

[the_background] =>

Chain flexibility and connectivity play pivotal roles in the unique properties of polymer materials, including crystallization, mechanics, and rheology. Nonetheless, the existing theories of polymer crystallization were established based on those of small molecules crystallization without considering the peculiar features of polymer. In order to achieve a better understanding of polymer crystallization, quantitative prediction with molecular details is necessary. Thus, chain flexibility and connectivity must be considered in the molecular theory of polymer crystallization. As an effort to realize that, this review focused on the impact of chain flexibility and connectivity in polymer materials. The output of the review paved a path as part of the critical steps to develop the theory of polymer crystallization.

[the_sdg_impact] =>

Polymers are indispensable in the facilitation of human life and are crucial for medication, communication, transportation, urbanization and more. The theory of polymer crystallization is listed as one of the top ten challenges in polymer science. Therefore, by revealing why and how polymer chains assemble into semicrystalline state, this study materialized UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s10118-022-2804-3 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/12/Polymer-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/12/21450012_1670984503.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s10118-022-2804-3 [original_article_reference_fields] => Array ( [publication_title] => Chain Flexibility and Connectivity: The Uniqueness of Polymer Crystallization [journal_title] => Chinese Journal of Polymer Science [publisher] => Springer Nature [year] => August 2022 [subject] => Polymer Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Ck_Ctc2dveU [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/12/CPP-5-1.mp4_snapshot_00.00_2022.12.14_10.34.51.jpg ) ) [10] => WP_Post Object ( [ID] => 35118 [post_author] => 154 [post_date] => 2022-11-12 13:48:19 [post_date_gmt] => 2022-11-12 05:48:19 [post_content] => [post_title] => State-of-the-Art CEPC 650 MHz Superconducting Radio-Frequency Cavity [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => state-of-the-art-cepc-650-mhz-superconducting-radio-frequency-cavity [to_ping] => [pinged] => [post_modified] => 2023-12-26 10:36:54 [post_modified_gmt] => 2023-12-26 02:36:54 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=35118 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SHA, Peng (沙鹏) [researchers_position] => Accelerator Division, Institute of High Energy Physics, Chinese Academy of Sciences, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/11/Gradient1.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0003-2545-7974 ) [researchers_info_2] => Array ( [researchers_name_2] => PAN, Weimin (潘卫民) [researchers_position_2] => Accelerator Division, Institute of High Energy Physics, Chinese Academy of Sciences, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/11/Gradient2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-6847-470X ) [original_article_reference] => [research_footprints] => SRF cavity; Accelerating gradient; Quality factor; Electropolishing; Vertical test [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/11/2022_NST_Article_09_v2-scaled.jpg [figures] => [video] => [the_novelty] =>

This study demonstrated that the Circular Electron Positron Collider (CEPC) 650 MHz single-cell superconducting radio-frequency (SRF) cavities could achieve ultrahigh accelerating gradient (Eacc) by applying a combination of buffered chemical polishing (BCP) and electropolishing (EP). The values of Eacc achieved were above 40 MV/m. Besides, after medium-temperature furnace baking, the SRF cavities achieved an ultrahigh Q0 of 8 × 1010 at 22 MV/m and an extremely low BCS resistance (RBCS) of ~1.0 nΩ at 2.0 K. Two 650 MHz SRF cavities were involved throughout the process of validating the effect of the combination of BCP and EP. By showing the pivotal roles of surface treatments on the performance of SRF cavities, the research output paved a clear path for future research on large SRF cavities.

[the_background] =>

The superconducting radio-frequency (SRF) cavity is a crucial component of particle accelerators, such as high-energy colliders, proton/neutron sources, free electron lasers and synchrotron light sources. The Circular Electron Positron Collider (CEPC) is a high-energy collider of the Higgs factory. The collider ring of the CEPC is equipped with hundreds of 650 MHz SRF cavities. To meet the high requirements of accelerators, the SRF cavities must exhibit high accelerating gradient (Eacc) and high intrinsic quality factor (Q0). The cavities are commonly treated by either buffered chemical polishing (BCP) or electropolishing (EP). However, SRF cavities processed by BCP face challenge in achieving high Eacc, owing to the high surface roughness brought about by BCP. On the other hand, although EP could render higher Eacc, it is a complicated process which also involves higher cost. As such, it was speculated that the combination of BCP and EP could be a feasible way for large SRF cavities to achieve high Eacc. To validate the feasibility of the combination of BCP and EP, this study applied the combined treatment on two 650 MHz SRF cavities and excellent results were obtained. Since the treatment procedures can be replicated easily, the output facilitates the advancement of future studies related to SRF.

[the_sdg_impact] =>

Particle accelerators play an important role in the advancement of high-energy and nuclear physics. The performance of SRF cavities is very critical as they greatly affect the scale and cost of particle accelerators. In order to contribute to the advancement of research related to SRF, this study developed a highly-feasible and remarkable technique which significantly enhanced the performance of 650 MHz SRF cavities. Therefore, its output showed good alignment with UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-022-01109-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/11/Gradient3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/11/20636347_1668231825.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-01109-8 [original_article_reference_fields] => Array ( [publication_title] => Ultrahigh accelerating gradient and quality factor of CEPC 650 MHz superconducting radio-frequency cavity [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => October 2022 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/3Qzi7Bljv9o [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/11/NST-09-w-subs-music-2.mp4_snapshot_00.00_2022.11.12_13.41.28.jpg ) ) [11] => WP_Post Object ( [ID] => 35097 [post_author] => 154 [post_date] => 2022-11-12 13:31:57 [post_date_gmt] => 2022-11-12 05:31:57 [post_content] => [post_title] => Nuclear System Design via JMCT3.0 Particle Transport Program [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => nuclear-system-design-via-jmct3-0-particle-transport-program [to_ping] => [pinged] => [post_modified] => 2023-12-26 10:31:51 [post_modified_gmt] => 2023-12-26 02:31:51 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=35097 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LI, Deng (邓力) [researchers_position] => Computational Physics Laboratory, Beijing Institute of Applied Physics and Computational Mathematics, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/11/JMCT3.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Advanced modeling; High-performance numerical simulation; Multi-physics coupled calculation; Large-scale parallel computing; JMCT [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/11/14-scaled.jpg [figures] => [video] => [the_novelty] =>

The JMCT3.0 (Joint Monte Carlo Transport 3.0) (latest version) has been coupled with depletion, thermal-hydraulics and fuel property for the simulation of reactor nuclear-hot feedback effects. Besides conducting multiphysics coupled calculations, one of JMCT3.0’s latest features is being able to work with the functions of proton, atmosphere and molecule transport. Since JMCT3.0 was developed based on the combinatorial geometry parallel infrastructure, JCOGIN, and the adaptive structured mesh infrastructure, JASMIN, it supports the geometry bodies, structured and unstructured meshes. Besides that, advanced algorithms (e.g. DD, UTD, OTF, and FCSBC) have been developed for JMCT3.0. Therefore, it is capable of simulating high-complexity device problems such as reactor physics, criticality safety analysis, radiation shielding, detector response, nuclear well logging, dosimetry calculations, and reactor nuclear-hot feedback effects. Moreover, high consistency was obtained by comparing JMCT3.0’s results and those from other state-of-the-art Monte Carlo programs like MC21, OpenMC, and KENO-VI. Future effort is being strategized to enhance the computing efficiency. The complication of uncertainty quantification and propagation of errors is an essential area to consider in the future. Furthermore, new algorithms need to be developed to reduce computing fees and JMCT is evolving progressively towards this goal.

[the_background] =>

The Monte Carlo method has given rise to the development of multiple physical programs for the study of nuclear science engineering, statistical physics, biomedicine, quantum mechanics, molecular dynamics, petroleum geophysical exploration, finance, information, operational research, polymer chemistry and more. Meanwhile, a general high-performance numerical simulation program JMCT was used to simulate neutron, photon, electron, proton, light radiation, atmosphere, and molecule transport. Especially for those problems which the memory exceeds the limit of a single core or node, JMCT can easily simulate by domain decomposition. At present, JMCT can simulate extremely complicated nuclear system problems and the high-precision numerical simulation results have been obtained. JMCT serves as a crucial complement to the existing numerical simulations for nuclear science studies. It will expand continuously and enhance the facilities as well as speed up the advancement of nuclear research.

[the_sdg_impact] =>

Via Monte Carlo numerical simulation, the physical quantities can easily obtain both measurable and immeasurable values, especially for some extreme conditions which are inaccessible by experiments. This indicates the necessity to keep enhancing the functions and capabilities of JMCT. Besides, the high upgradability of JMCT shows great potential to fill in the demand gap between numerical simulations and experiments. Hence, by developing JMCT3.0, this study fulfils UNSDG Goal 9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-022-01092-0 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/11/JMCT32.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/11/20636119_1668230264.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-01092-0 [original_article_reference_fields] => Array ( [publication_title] => A high fidelity general purpose 3-D Monte Carlo particle transport program JMCT3.0 [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => August 2022 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/2_-LGHS6tjA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/11/NST22-06-with-Chinese-Sub-v3.mp4_snapshot_00.00_2022.11.12_13.32.14.jpg ) ) [12] => WP_Post Object ( [ID] => 34848 [post_author] => 154 [post_date] => 2022-10-24 19:30:22 [post_date_gmt] => 2022-10-24 11:30:22 [post_content] => [post_title] => Boosting Propane Dehydrogenation with Nanostructured Catalysts [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => boosting-propane-dehydrogenation-with-nanostructured-catalysts [to_ping] => [pinged] => [post_modified] => 2024-02-19 13:36:44 [post_modified_gmt] => 2024-02-19 05:36:44 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34848 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GONG, Jinlong (巩金龙) [researchers_position] => School of Chemical Engineering & Technology, Tianjin university, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/10/Dehydrogenation.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0001-7263-318X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Alkyls; Catalysts; Organic reactions; Oxides,Platinum [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/10/AMR_Article_01_v2_EN-1-scaled.jpg [figures] => [video] => [the_novelty] =>

Is there any room to improve the existing dehydrogenation catalysts? The research of the Energy and Catalysis Adventure Team (ECAT) from Tianjin University shows comprehensively how metal and metal oxide nanostructured catalysts (NCs) can be controlled to enhance the efficiency of propane dehydrogenation (PDH). The efficiency is tackled from three main aspects i.e. the NC’s composition, defects, and confinement. The introduction of promoters and supports contributes to higher PDH efficiency. For metal NCs (e.g. Pt-based), the increase of geometric separation and charge density of surface active sites have successfully increased the PDH efficiency, attributing to the prevented coke deposition and nanoparticles sintering (which can also be inhibited by zeolite framework confinement). The ECAT group has demonstrated that single-atom/intermetallic alloys with higher isolation degree and electron density could be potentially employed for highly efficient PDH processes. For metal oxide NCs (e.g. VOx-based), inducing intrinsic defect sites has increased the PDH efficiency. Dispersion as well as confinement of NC in nanoporous materials could result in higher oxide activity and stability. The feasibility of catalysts based on lower-cost transition metals (e.g. nickel, iron, and cobalt) has been investigated as replacements. The ECAT group has further developed novel processes such as chemical looping oxidative dehydrogenation technology to break the thermodynamic equilibrium limitation of conversion in conventional PDH. The ECAT group currently focuses on the scale-up of the nanostructured catalyst manufacturing and the optimization of PDH process to promote the industrial production of propylene.

[the_background] =>

The existing commercial-grade Pt- and CrOx-based catalysts have been showing promising performance in the mass production of propylene. However, the need for high working temperature (>500 °C) is causing adverse effects on the overall efficiency of propane dehydrogenation (PDH). Due to the limitations, nanostructured catalysts (NCs) have received attention for their tunable properties to achieve better PDH efficiency. Since the PDH efficiency is held back by the instability of the NCs, this research focuses on optimizing the performance through controllable regulation of metal- and oxide-based NCs. Beyond demonstrating the effective methods to obtain higher PDH efficiency, the outcomes of this research also serve as a significant reference for future studies related to PDH.

[the_sdg_impact] =>

Propylene, with its global annual production approaching 100 million tonnes, is essential in chemical manufacturing. If its production efficiency can be further enhanced, this will help to maintain the affordability of a wide range of chemicals. In order to realize this goal, this study has come up with feasible and effective methods for more efficient PDH. Thus, by enhancing the research on propylene production, their achievement is very well-aligned with UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://pubs.acs.org/doi/10.1021/accountsmr.0c00012 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/10/Dehydrogenation-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/10/20143753_1666610773.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1021/accountsmr.0c00012 [original_article_reference_fields] => Array ( [publication_title] => Nanostructured Catalysts toward Efficient Propane Dehydrogenation [journal_title] => Accounts of Materials Research [publisher] => ACS Publication [year] => September 2020 [subject] => Material Science; Chemistry ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/p1digPPsnLg [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/10/AMR01v7-2022.10.21.mp4_snapshot_00.01_2022.10.24_17.44.12.jpg ) ) [13] => WP_Post Object ( [ID] => 34590 [post_author] => 154 [post_date] => 2022-10-12 16:01:11 [post_date_gmt] => 2022-10-12 08:01:11 [post_content] => [post_title] => Fabrication of Nanofiltration Membranes via Surface and Interface Engineering [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => fabrication-of-nanofiltration-membranes-via-surface-and-interface-engineering [to_ping] => [pinged] => [post_modified] => 2023-11-21 13:46:27 [post_modified_gmt] => 2023-11-21 05:46:27 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34590 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ZHU, Cheng-Ye (朱城业) [researchers_position] => Department of Polymer Science and Engineering, Zhejiang University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/10/Nanofiltration-.png [researchers_profile] => https://www.researchgate.net/profile/Cheng-Ye-Zhu [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => GUO, Bian-Bian (郭变变) [researchers_position_2] => Department of Polymer Science and Engineering, Zhejiang University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/10/Nanofiltration-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Bian-Bian-Guo [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Nanofiltration; Thin-film composite membranes; Mussel-inspired deposition; Interfacial polymerization [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/10/2022_CPP_Article_03_v1_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

A team of researchers successfully constructed nanofiltration membranes with superior quality using the mussel-inspired deposition methods. Such was achieved via a two-part approach to fabricate the thin-film composite (TFC) nanofiltration membranes. Firstly, the substrate surface was coated through fast and novel deposition to form a dense, robust, and functional selective layer. Then, the structure controllability of the selective layer was enhanced by optimizing the interfacial polymerization (IP) process. As a result, the properties of nanofiltration membranes produced are with high durability and added functionality. When put into a bigger perspective, these high-performance TFC nanofiltration membranes are potential solutions to a number of fields, including water softening, wastewater treatment, and pharmaceutical purification. Hence, there is a need to further explore and expand the application in an industrial scale instead of being bound within the walls of the laboratories.

[the_background] =>

Membrane-based technologies, especially enhanced nanofiltration systems, have been highly explored due to their myriad of distinct properties, primarily for their high efficiency, mild operation, and strong adaptability. Among these, the TFC nanofiltration membranes are favoured for their smaller molecular weight cutoff, and narrower pore size distribution which lead to higher divalent and multivalent ion rejection ability. Moreover, these membranes show better designability owing to their thin selective layer make-up and porous support with different chemical compositions. However, the interfacial polymerization (IP) rate of reaction is known to affect the permeability and selectivity of the TFC nanofiltration membranes by weakening the controllability of the selective layer structure. Therefore, this study was designed to improve the structural quality of the TFC nanofiltration membranes through surface and interface engineering, and subsequently, increase the functionality.

[the_sdg_impact] =>

It is one of the ambitions of the United Nations to ensure availability and sustainable management of water and sanitation for all (SDG 6: Clean water and sanitation). A report by the United Nations’ Water for Life initiative stated that one in four people do not have access to safe drinking water, and up to 50% of the global population are at risk of living in water stressed areas by 2025. With such concerns looming close, undoubtably, there is a demand for advanced and efficient wastewater treatment technology to be put in place. Thus, the successful designing of improved and highly functional TFC nanofiltration membranes through innovative approaches portrayed in this study could be the much-needed solution in addressing these issues.

[article_url] => https://link.springer.com/article/10.1007/s10118-022-2654-z [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/10/Nanofiltration-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/10/19839698_1665561276.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s10118-022-2654-z [original_article_reference_fields] => Array ( [publication_title] => Surface and Interface Engineering for Advanced Nanofiltration Membranes [journal_title] => Chinese Journal of Polymer Science [publisher] => Springer Nature [year] => January 2022 [subject] => Engineering; Polymer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/ALNxP3V3Jms [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/10/Screenshot-2022-10-12-131104.png ) ) [14] => WP_Post Object ( [ID] => 34569 [post_author] => 154 [post_date] => 2022-10-12 13:02:47 [post_date_gmt] => 2022-10-12 05:02:47 [post_content] => [post_title] => Well-controlled Permeability of the Polymersomes for Efficient Drug Delivery [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => well-controlled-permeability-of-the-polymersomes-for-efficient-drug-delivery [to_ping] => [pinged] => [post_modified] => 2023-11-21 13:44:57 [post_modified_gmt] => 2023-11-21 05:44:57 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34569 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => DU, Jianzhong [researchers_position] => Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/10/Polymersomes-3.png [researchers_profile] => https://www.researchgate.net/profile/Jianzhong-Du [researchers_second_profile] => https://orcid.org/0000-0003-1889-5669 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Polymersome; Drug delivery; Phase separation; Programmed drug release [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/10/2022_CPP_Article_02_v5_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

This research designed polymersomes with inhomogeneous membranes capable of programmed drug release with accurate control by modifying the molecular architecture and photo-cross-linking degree of the polymer. The process involved introduced crystalline PCL moiety as part of the membrane’s molecular structure via the synthesis of three polymersomes with different hydrophobic chains, PEO43-b-P(CL45-stat-CTCL25), PEO43-b-P(CL108-stat-CTCL16), and PEO43-b-PCTCL4-b-PCL79. As a result of the amorphous PCTCL moieties in the membranes, high permeability with finely tunable drug release rate was achieved. A series of mesoscopic dynamics (MesoDyn) simulations and doxorubicin release tests affirmed that the membrane permeability is indeed related to the membrane phase separation of the polymersome. In conclusion, membrane phase separation technique used for the modification of polymersomes improved programmed drug release rate; thus, promising great significance in the field of drug delivery.

[the_background] =>

In the field of biomedicine, small molecules relied on membranes such as polymersomes as carriers for drug delivery. Thus, the effectiveness and efficiency of drug delivery become key focus points when considering treatment development for a range of diseases, including cancer. Despite being heavily researched and among the promising choice as drug delivery vessels, conventional polymersome membranes lack efficiency due to its homogeneity, making it harder for the drug to be released. This led to recent research centering their attentions in modifying and customizing polymersome membranes to allow programmed release of small molecular drugs to meet the demands of biomedical practices. As a continuation of past efforts, this research intends to overcome the challenge of high permeability of the PCTCL-based polymersomes caused by their amorphous nature, rendering it efficient to deliver small molecules for broader applications.

[the_sdg_impact] =>

As the global population continues to expand along with longevity, the importance and use of medicines are expected to increase. However, this will lead to a greater impact on the ecosystem and our health in the long term. Hence, there is a growing need to support precision medicine and to reduce ineffective medicine use which could burden patient, society and environment in the long run. The outcome of this research, the enhanced capability of programmed drug release via the modification of polymersomes, meets such demand. (SDG 3: Good health and well-being)

[article_url] => https://link.springer.com/article/10.1007/s10118-022-2683-7 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/10/Polymersomes.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/10/19836336_1665548579.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s10118-022-2683-7 [original_article_reference_fields] => Array ( [publication_title] => Controlling Membrane Phase Separation of Polymersomes for Programmed Drug Release [journal_title] => Chinese Journal of Polymer Science [publisher] => Springer Nature [year] => February 2022 [subject] => Medical; Drug Delivery ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/eekAA9OeTkE [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/10/Screenshot-2022-10-12-130439.png ) ) [15] => WP_Post Object ( [ID] => 34544 [post_author] => 154 [post_date] => 2022-10-10 11:08:52 [post_date_gmt] => 2022-10-10 03:08:52 [post_content] => [post_title] => Optimized Deep Learning Model Utilizes Chest X-ray Scans for Automated COVID-19 Detection [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => optimized-deep-learning-model-utilizes-chest-x-ray-scans-for-automated-covid-19-detection [to_ping] => [pinged] => [post_modified] => 2022-10-28 13:24:04 [post_modified_gmt] => 2022-10-28 05:24:04 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34544 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SWAMY, Siddhalinga P C [researchers_position] => Department of Computer Science & Engineering, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/10/radiological-3.jpg [researchers_profile] => https://www.researchgate.net/profile/Siddalingaswamy-P-C [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Covid-19; CNN; Ensemble; ECOC; GWO; SVM; WOA [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Based on the study, the Convolution Neural Network (CNN) model, which is a deep learning-based model optimized through the proposed methodology, can successfully detect COVID-19 cases and distinguish chest X-ray images of viral pneumonia patients and COVID-19 apart from healthy individuals. Two datasets of chest X-ray images consisting of normal, COVID-19 and viral pneumonia were used for training and testing the CNN model. The model was tested with dataset 1 and optimized through automatic tuning of hyper parameters. Then, dataset 2 was used to train and test the model with the parameters being constant from the previous testing. The results indicated that the proposed deep learning-based model showed 98% and 96% classification accuracy for datasets 1 and 2, respectively. However, further testing of the efficiency of the model should be carried out using a robust dataset consisting of images of various respiratory diseases.

[the_background] =>

The study is carried out to develop an optimized Convolution Neural Network (CNN) model that could be potentially used as an automated diagnostic tool for screening COVID-19 patients using chest X-ray scans. The study indicated that other diagnostic techniques designed using CNN showed limitations, such as the accuracy of the models in classifying COVID-19 was affected by the images used for training. This is because the changes in the image pixels caused by rotation and resize actions were not considered during the model's optimization procedure. As a result, the models fail to classify COVID-19 affected chest X-ray scans apart from normal and viral pneumonia chest X-ray scans. The proposed deep learning-based model aims to address the limitations demonstrated by previous deep learning-based models to increase the accuracy of COVID-19 detection.

[the_sdg_impact] =>

The COVID-19 outbreak, which was declared a global pandemic has resulted in a major global crisis and has taken more than 6 million lives worldwide as reported by World Health Organization (WHO). In the study, the optimized deep learning-based model is a potential diagnostic tool for COVID-19 detection due to its higher accuracy compared to existing gold standard diagnostic tools. The UN’s Sustainable Development Goal (SDG) strongly associated with the study is “Goal 3: Good Health and Well-Being”. The study is also linked with “Goal 9: Industry, Innovation and Infrastructure” as the innovation of using chest X-ray images to train and optimize a deep learning-based model can be used to replace the existing diagnostic tool and prevent any misclassification among patients.

[article_url] => https://www.sciencedirect.com/science/article/pii/S1568494621001617 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/10/CNN-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/10/19779454_1665371033.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.asoc.2021.107238 [original_article_reference_fields] => Array ( [publication_title] => Automated Detection of Covid-19 from Chest X-ray scans using an optimized CNN architecture [journal_title] => Applied Soft Computing [publisher] => Elsevier [year] => June 2021 [subject] => Medical; Covid-19 ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [16] => WP_Post Object ( [ID] => 34527 [post_author] => 154 [post_date] => 2022-10-10 10:52:49 [post_date_gmt] => 2022-10-10 02:52:49 [post_content] => [post_title] => Development of COVID-19 Diagnostic Tool via Deep Learning Models Trained with Patient’s Chest X-ray and CT Images [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => development-of-covid-19-diagnostic-tool-via-deep-learning-models-trained-with-patients-chest-x-ray-and-ct-images [to_ping] => [pinged] => [post_modified] => 2022-10-10 10:58:32 [post_modified_gmt] => 2022-10-10 02:58:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34527 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SIDDESHAPPA, Nandish [researchers_position] => School of Information Sciences, Manipal University, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => COVID19; Deep Learning; Artificial Intelligence; Classification; Prediction [graphic_abstract] => [figures] => [video] => [the_novelty] =>

In the study, the pre-trained model, VGG16, demonstrated the most consistent performance compared to other deep-learning-based models. This was concluded by the results that indicated the validation accuracy of VGG16 was 76.6% and 87.76% for CT and X-ray images, respectively. The study was conducted by training, testing, and validating several models with CT and X-ray images from COVID-19 and non-COVID-19 patients, followed by quantifying various parameters. In the study, the validation accuracy of Xception was the highest when trained with X-ray images, whereas the validation accuracy of VGG19 was highest when trained with CT images. Furthermore, the use of X-ray images for training has indicated better outcomes among models than CT images for training. However, further testing of the models with more epochs during training can improve the existing accuracy of the models. Moreover, larger datasets should be used to further improve the training of the models.

[the_background] =>

The reverse transcription-polymerase chain reaction (RT-PCR), the gold standard for COVID-19 detection, has drawbacks, such as false positive or false negative, and has an average accuracy rate of 63%. As a result, the study aimed to develop deep learning-based models as potential alternatives for existing COVID-19 diagnostic tools. The deep learning-based models are effective diagnostic tools due to the high accuracy in detecting COVID-19 patients based on radiological images. Moreover, deep learning techniques can identify underlying features in the radiological images, which contributes to the accuracy of diagnosis. In the study, the impact of using CT and X-ray images on the performance of models was compared for the first time as no previous studies carried out a comparative study between CT and X-ray images.

[the_sdg_impact] =>

The use of deep learning techniques with radiological images is a potential diagnostic tool due to its higher accuracy for COVID-19 detection as compared to the current gold standard of COVID-19 detection. The UN Sustainable Development Goal (SDG) addressed by this study is “Goal 3: Good Health and Well-Being”. The World Health Organization (WHO) declared the COVID-19 outbreak a global pandemic on 11 March 2020. A diagnostic tool with high accuracy is important for COVID-19 detection to prevent false identification among patients and help curb the spread of the disease. Another UN Sustainable Development Goal (SDG) strongly associated with the study is “Goal 9: Industry, Innovation and Infrastructure”. The outcome of this study can create a huge impact on the medical industry as the potential diagnostic tool can aid doctors and researchers in stopping the spread of the virus.

[article_url] => https://f1000research.com/articles/10-1292 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/10/radiological-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/10/19779266_1665370010.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.12688/f1000research.74839.1 [original_article_reference_fields] => Array ( [publication_title] => X-ray versus computerized tomography (CT) images for detection of COVID-19 using deep learning [version 1; peer review: awaiting peer review] [journal_title] => - [publisher] => Floor1000 Research [year] => December 2021 [subject] => Medical; Covid-19 ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [17] => WP_Post Object ( [ID] => 34515 [post_author] => 154 [post_date] => 2022-10-10 10:34:58 [post_date_gmt] => 2022-10-10 02:34:58 [post_content] => [post_title] => Greater Team Performance: Role of Shared Transformational Leadership, Workplace Spirituality & Team Reflexivity [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => greater-team-performance-role-of-shared-transformational-leadership-workplace-spirituality-team-reflexivity [to_ping] => [pinged] => [post_modified] => 2022-10-10 10:38:21 [post_modified_gmt] => 2022-10-10 02:38:21 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34515 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PRABHU, Nandan [researchers_position] => Manipal Institute of Management, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/10/csr3.png [researchers_profile] => https://www.researchgate.net/profile/Nandan-Prabhu [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Shared transformational leadership; Team performance; Team reflexivity, Workplace spirituality [graphic_abstract] => [figures] => [video] => [the_novelty] =>

For the first time, shared transformational leadership and workplace spirituality have been proven to be essential to higher team reflexivity. Besides, this study shows that both workplace spirituality and team reflexivity play an important role in mediating the relationship between shared transformational leadership and team performance. Meanwhile, workplace spirituality also mediates the relationship between shared transformational leadership and team reflexivity. 130 ongoing teams working in India’s information technology sector were involved in the data-collection process. The data on shared transformational leadership were collected by adopting the referent-shift consensus method. Since the impact of trust among team members is not considered, future research may examine the mediating influence of team trust in the relationship between shared transformational leadership and workplace spirituality.

[the_background] =>

In an organization, shared transformational leadership is valuable in building linkages between the team’s mission and the values of associates. The result is crucial in inspiring a shared vision, raising team members’ awareness of their team’s objectives, and creating a conducive space for reflection on the team’s work. Hence, this form of shared leadership could potentially be the main driving force behind team performance. Past studies imply that higher team reflexivity can be achieved by creating a sense of community among team members. This gives rise to the idea that workplace spirituality is an antecedent of team reflexivity. To date, the influence of workplace spirituality on team performance remains ambiguous. To fill up the existing knowledge gap, this study investigates the relationship between the constructs of shared transformational leadership and team performance. Furthermore, it examines the mediating roles of workplace spirituality and team reflexivity in various relationships involving shared transformational leadership. The outcomes are potential indicators for managerial staff to develop managing methods that emphasize shared transformational leadership and workplace spirituality.

[the_sdg_impact] =>

Team performance and effectiveness are the critical determinants for the success of a business unit. On the other hand, upholding team performance has been the main challenge not only for a team leader but also for the organization involved. This research managed to determine several factors that significantly influence team performance both directly and indirectly. By promoting the importance of decent management styles and a positive workplace for work performance., this research achieves UNSDG 8: Decent Work & Economic Growth.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/SAJBS-07-2020-0246/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/10/Transformational-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/10/19779003_1665368259.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/SAJBS-07-2020-0246 [original_article_reference_fields] => Array ( [publication_title] => Does workplace spirituality influence reflexivity in ongoing teams? Examining the impact of shared transformational leadership on team performance [journal_title] => South Asian Journal of Business Studies [publisher] => Emerald Publishing [year] => March 2021 [subject] => Business; Leadership ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [18] => WP_Post Object ( [ID] => 34501 [post_author] => 154 [post_date] => 2022-10-10 10:05:17 [post_date_gmt] => 2022-10-10 02:05:17 [post_content] => [post_title] => Impact of Mandatory CSR on Cost of Papital [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => impact-of-mandatory-csr-on-cost-of-papital [to_ping] => [pinged] => [post_modified] => 2022-10-10 10:39:31 [post_modified_gmt] => 2022-10-10 02:39:31 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34501 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PRABHU, Nandan [researchers_position] => Manipal Institute of Management, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/10/csr3.png [researchers_profile] => https://www.researchgate.net/profile/Nandan-Prabhu [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Corporate social responsibility; cost of capital; cost of debt; cost of equity; mandatory CSR legislation; policy intervention; signaling theory [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study provided theoretical insights on the impact of mandatory corporate social responsibility (CSR) on the costs of debt (COD) and equity (COE) of non-financial firms in India. It was determined that higher CSR leads to lower COD and higher COD. However, following the 2014 policy on mandatory CSR spending and reporting, findings indicated an increase in COD and COE. Unlike voluntary CSR, policy intervention in mandating CSR creates a negative signal among socially responsible investors, especially where the intention is of concern. As a whole, the outcome of the study contributes significantly to the extant literature in terms of policy intervention effects on the relationship between CSR, COD, and COE.

[the_background] =>

In 2014, India became the first nation to announce mandatory CSR legislation as an effort to boost philanthropic giving culture across all sectors. Past literature reported that firms with superior voluntary CSR performance, more often than not, gain favorable treatment in capital markets due to an optimistic investor attitude. However, active participation in CSR activities is not received in the same manner globally as investors in some countries may view CSR negatively. Moreover, making CSR mandatory could influence the nature and impact of signal intentionality on investors. Therefore, this study aims to understand the impact of policy intervention with regard to CSR performance and its relationship with COD and COE.

[the_sdg_impact] =>

Practicing corporate social responsibility (CSR) voluntarily incorporates economic, social, and environmental responsibilities into business operations to foster sustainable business growth while positively impacting the environment and the community. Clearly, mandating such practice across all business sectors would significantly impact the business and economic development. Therefore, the findings of this study could benefit economists and policymakers in understanding these impacts as well as further stimulate industry-driven R&D. (SDG 8: Decent work and economic growth)

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0275531922000083 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/10/CSR.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/10/19778775_1665367024.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.ribaf.2022.101620 [original_article_reference_fields] => Array ( [publication_title] => Corporate social responsibility and cost of capital: The moderating role of policy intervention [journal_title] => Research in International Business and Finance [publisher] => Elsevier [year] => April 2022 [subject] => Business; Finance ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [19] => WP_Post Object ( [ID] => 34334 [post_author] => 154 [post_date] => 2022-09-14 14:44:31 [post_date_gmt] => 2022-09-14 06:44:31 [post_content] => [post_title] => State-of-the-art Commercial 600 MWe HTGR Nuclear Power Plant [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => state-of-the-art-commercial-600-mwe-htgr-nuclear-power-plant [to_ping] => [pinged] => [post_modified] => 2023-12-26 10:33:53 [post_modified_gmt] => 2023-12-26 02:33:53 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34334 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => DONG, Yujie [researchers_position] => Institute of Nuclear and New Energy Technology, Tsinghua University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/09/HTGR-3.png [researchers_profile] => https://www.researchgate.net/profile/Yujie-Dong-3 [researchers_second_profile] => https://orcid.org/0000-0003-0452-4322 ) [researchers_info_2] => Array ( [researchers_name_2] => WANG, Haitao [researchers_position_2] => Institute of Nuclear and New Energy Technology, Tsinghua University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/09/HTGR-4.png [researchers_profile_2] => https://www.researchgate.net/profile/Haitao-Wang-59 [researchers_second_profile_2] => https://orcid.org/0000-0003-3704-9214 ) [original_article_reference] => [research_footprints] => High-temperature gas-cooled reactor; Module; HTR-PM600; Generation IV [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/09/2022_NST_Article_07_v2f_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

In order to commercialize the high-temperature gas-cooled reactor pebble-bed module (HTR-PM) demonstration project, this study developed the HTR-PM600, i.e. a 600 MWe high temperature gas-cooled reactor nuclear power plant. With a nuclear island size that is comparable to a domestic pressurized water reactor (PWR) of the same power level, the HTR-PM600 comprises six reactors modules directly replicated from HTR-PM. All of the modules are connected to a single steam turbine. Notably, the six reactor modules are accommodated by a large circular ventilated low-pressure containment (VLPC) which lowers the overall volume of the reactor building, optimizes the arrangement of the steam and feedwater pipes, provides close references of industrial foundations as well as experiences from PWR nuclear power plants, and achieves improved capacity of radioactive retention. The safety features of HTR-PM600 are identical to those of the HTR-PM whereby each reactor module is physically independent and isolated by its own concrete cavity. In addition, six separated reactor cavity cooling system (RCCS) are placed on the outer surface of the upper part of the containment. With the adoption of proven technology from HTR-PM, reference to layout practices of the PWR, and improved efficiency as well as cost, the HTR-PM600 is an economically competitive Generation IV nuclear energy technology.

[the_background] =>

The remarkable pebble-bed high-temperature gas-cooled reactor (HTGR) invented by Professor R. Schulton has led to the materialization of the 45 MWt AVR pebble HTG experimental reactor and 750 MWt THTR HTGR demonstration power station. Meanwhile, the concept of a ‘modular’ HTGR technology with inherent safety features gave rise to the development of a 200 MWt modular pebble-bed HTGR (i.e. HTR-Module) which has not been constructed to date. Following the rapid advancement in HTGR technology, scientists in China have successfully developed the HTR-10 and HTR-PM (i.e. a 200 MWe pebble-bed modular HTGR nuclear power demonstration plant) in the 1990’s and 2000’s, respectively. The achievement of HTR-PM indicated the readiness for the commercialization phase. Therefore, the HTR-PM600, an enhanced version of HTR-PM, was planned and executed primarily for commercialization purpose. The triumphant implementation of HTR-PM600 marks a significant milestone in the global development of Generation IV nuclear power technology.

[the_sdg_impact] =>

Nuclear energy is the second-largest source of low-carbon electricity behind hydropower. The high-energy density of nuclear energy is essential in addressing the existing energy gap, implying the need for extensive research to develop an economically competitive nuclear energy technology. The materialization of HTR-PM600 paves a path to the implementation of commercial Generation IV nuclear power plants and, thus, this study realizes UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-022-01089-9 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/09/HTGR-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/09/19126403_1663137594.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-01089-9 [original_article_reference_fields] => Array ( [publication_title] => 600-MWe high-temperature gas-cooled reactor nuclear power plant HTR-PM600 [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => August 2022 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/OOmXvk27vVU [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/09/NST-07-w-sub-music.mp4_snapshot_00.07_2022.10.27_15.53.42.jpg ) ) [20] => WP_Post Object ( [ID] => 34313 [post_author] => 154 [post_date] => 2022-09-14 14:29:35 [post_date_gmt] => 2022-09-14 06:29:35 [post_content] => [post_title] => New SSRF Facility: Laser Electron Gamma Beamline SLEGS [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => new-ssrf-facility-laser-electron-gamma-beamline-slegs [to_ping] => [pinged] => [post_modified] => 2023-12-26 10:17:23 [post_modified_gmt] => 2023-12-26 02:17:23 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34313 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => XU, Hanghua (许杭华) [researchers_position] => SLEGS, Institution: Shanghai Advanced Research Institute, CAS, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/09/SLEGS3.png [researchers_profile] => https://www.researchgate.net/profile/Hanghua-Xu [researchers_second_profile] => https://orcid.org/0000-0002-7424-891X ) [researchers_info_2] => Array ( [researchers_name_2] => WANG, Hongwei (王宏伟) [researchers_position_2] => SLEGS, Institution: Shanghai Advanced Research Institute, CAS, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/09/SLEGS4.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-8178-0605 ) [original_article_reference] => [research_footprints] => SLEGS; Laser Compton scattering; Slant-scattering mode; Backscattering mode [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/09/2022_NST_Article_05_v2f_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

The state-of-the-art Shanghai Laser Electron Gamma Source (SLEGS) has officially completed its commissioning which lasted from July to December 2021. Other than a back-scattering mode, for the first time, a slant-scattering mode is adopted in the SLEGS beamline to generate powerful quasi-monoenergetic gamma-ray beams systematically. With an energy spread of 2 – 15 %, a gamma-ray beam with energy ranging from 0.25 to 21.1 MeV in slant-scattering at collision angles ranging from 20 – 160° is generated. In back-scattering at 180°, the beam achieves maximum energy of 21.7 MeV. Notably, a 2 % energy resolution can achieved with a 1-mm or smaller collimator. The SLEGS beamline primarily comprises four components: i) a 100-W CO2 laser and laser transport; ii) an interaction chamber (slant-scattering) and a multi-function chamber (back-scattering); iii) two-stage coarse and fine collimators and a gamma flux attenuator; and iv) an experimental hutch, an experimental detector, a gamma absorber, and a data acquisition system. In order to establish a more in-depth understanding of the energy resolution, more realistic Geant4 simulations can be deployed to carry out a thorough analysis in the future.

[the_background] =>

The laser Compton scattering (LCS) gamma source is currently the most advanced quasi-monoenergetic gamma-ray source supporting photonuclear physics research. Meanwhile, slant-scattering is an essential technology to produce gamma-ray beams with tunable energy at synchrotron radiation facilities which operate at fixed electron beam energy. Hence, in an attempt to establish a world-class high-energy laser electron gamma source, scientists in China have recently commissioned the Shanghai Laser Electron Gamma Source (SLEGS) which adopt both slant- and back-scattering mode to yield MeV gamma-ray beams. By doing so, a new milestone has been achieved by the Shanghai Synchrotron Radiation Facility (SSRF) for having a total of 16 beamline stations in its Phase II Project. With the readiness of SLEGS in facilitating both basic and applied research in nuclear physics, scientists will have more space and opportunity to contribute to the advance of the nation’s nuclear technology.

[the_sdg_impact] =>

To-date, the number of facilities with high-energy laser electron gamma sources dedicated to nuclear science studies remains scanty globally. Since SLEGS is a high-potential multi-functional experimental platform, the addition of SLEGS to the Shanghai Synchrotron Radiation Facility will be of significant impact to the expansion of nuclear research, especially in China. By supporting the advancement of nuclear technology, this study shows good alignment with United Nations Sustainable Development Group (UNSDG) 9: Industry, innovation & infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-022-01076-0 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/09/SLEGS.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/09/19126082_1663136692.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-01076-0 [original_article_reference_fields] => Array ( [publication_title] => Commissioning of laser electron gamma beamline SLEGS at SSRF [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => July 2022 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/AT-1oC0ixaE [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/09/NST-05-w-subs-music-2022.08.30.mp4_snapshot_00.10_2022.10.27_15.55.44.jpg ) ) [21] => WP_Post Object ( [ID] => 34249 [post_author] => 154 [post_date] => 2022-08-15 15:37:56 [post_date_gmt] => 2022-08-15 07:37:56 [post_content] => [post_title] => High-Accuracy Mortality Evaluation by 24-h Urine Creatinine Excretion Rate Adjustment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => high-accuracy-mortality-evaluation-by-24-h-urine-creatinine-excretion-rate-adjustment [to_ping] => [pinged] => [post_modified] => 2022-11-14 10:31:58 [post_modified_gmt] => 2022-11-14 02:31:58 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34249 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KUO, Chin-Chi (郭錦輯) [researchers_position] => College of Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/blood-.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-2050-1377 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Mortality; Serum calcium; Estimated glomerular filtration rate; Kidney disease; body surface area; Renal disease; sarcopenia; estimated GFR; dual-energy X-ray absorptiometry; kidney function; Creatinine clearance; body mass index; serum creatinine; Modification of Diet in Renal Disease; glomerular filtration rate; renal replacement therapy; urine creatinine; end-stage renal disease [graphic_abstract] => [figures] => [video] => [the_novelty] =>

By implementing the 24-h urine creatinine excretion rate (U-CER) adjustment method, this study has successfully eliminated the paradoxical mortality in patients with high estimated glomerular filtration rate (eGFR). In other words, the 24-h U-CER–adjusted eGFR allowed a more accurate evaluation of mortality risk. The inclusion of muscle mass in the estimations was able to correct the bias. These results also served as the first empirical evidence proving the impact of sarcopenia on the paradoxical mortality pattern in the patients. For validation, future study may examine the effectiveness of this approach by implementing it in different ethnic populations and health care systems. Moreover, the feasibility of 24-h U-CER in monitoring excessive muscle loss over the course of chronic kidney disease (CKD) should be investigated in the future.

[the_background] =>

The GFR indicates how much blood our kidneys clean every minute based on our body size. The methods to evaluate GFR include measured glomerular filtration rate (mGFR), estimated glomerular filtration rate (eGFR), and 24-h creatinine clearance (CrCl). Although mGFR is known to be the gold standard for measuring kidney function, it is costly and inefficient. Meanwhile, 24-h creatinine clearance (CrCl) faces several setbacks, such as inaccurate estimation of GFR and being inconvenient, even though it has higher applicability for patients with sarcopenia or malnutrition. Estimated GFR (eGFR) based on equations (i.e. Modification of Diet in Renal Disease [MDRD] and Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]) have shown discrepancies and low feasibility. Moreover, a paradoxically increased risk of mortality was also reported. Nonetheless, the calculation of eGFR based on CKD-EPI is recognized as a good practice since 2012. Despite having various locally-derived eGFR equations, they are not systematically compared with 24-h CrCl-adjusted equation-based eGFR in terms of mortality prediction. Moreover, since decreased muscle mass is the main factor giving rise to the high eGFR–high mortality paradox, the 24-h urine creatinine excretion rate (24-h U-CER) (i.e. a 24-h CrCl method) is suitable for adjusting the equation-based eGFR for its effectiveness in measuring muscle mass. Therefore, this study compared the performance of equation methods for predicting 5-year all-cause mortality by applying 24-h CrCl, equation-based eGFRs, and 24-h U-CER. The reversal of paradoxically high mortality achieved by applying 24-h U-CER is a significant milestone towards more accurate kidney diagnosis.

[the_sdg_impact] =>

10% of the global population is affected by CKD. Thus, a technique for high-precision eGFR is crucial for early diagnosis and treatment of CKD. The 24-h U-CER–adjusted eGFR developed by this study exhibits high accuracy in mortality risk evaluation and, more importantly, it is ready to be adopted by health care systems. By contributing to the enhancement of health care, this study shows good alignment with UNSDG 3: Good Health & Well-Being.

[article_url] => https://onlinelibrary.wiley.com/doi/10.1002/jcsm.12951 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Paradoxical-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18343137_1660548630.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1002/jcsm.12951 [original_article_reference_fields] => Array ( [publication_title] => Paradoxical mortality of high estimated glomerular filtration rate reversed by 24-h urine creatinine excretion rate adjustment: sarcopenia matters [journal_title] => Journal of Cachexia Sarcopenia and Muscle [publisher] => Wiley Publishing [year] => March 2022 [subject] => Medical; Medicine; Kidney Disease ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/UqHYLRZ-fNA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/11.mp4_snapshot_00.00_2022.10.26_14.53.26.jpg ) ) [22] => WP_Post Object ( [ID] => 34235 [post_author] => 154 [post_date] => 2022-08-15 14:58:51 [post_date_gmt] => 2022-08-15 06:58:51 [post_content] => [post_title] => Unveiling the Binding Mode between Bacterial STING & c-di-GMP [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => unveiling-the-binding-mode-between-bacterial-sting-c-di-gmp [to_ping] => [pinged] => [post_modified] => 2022-11-05 15:00:35 [post_modified_gmt] => 2022-11-05 07:00:35 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34235 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHEN, Yeh (陳曄) [researchers_position] => Institute of New Drug Development, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/Crystal.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-7740-0446 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => crystal structure; molecular replacement; pathogen-associated molecular patterns; isothermal titration calorimetry; E. coli; multi-wavelength anomalous dispersion [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Upon identifying two complex crystal structures of bacterial STING/c-di-GMP, this study reveals the precise binding mode of c-di-GMP to the bacterial STING. The findings clarify how bacterial STING differentiates c-di-GMP second messengers from other cyclic dinucleotides during viral infections. Besides that, the interaction between bacterial STING and c-di-GMP is found to be accountable for the oligomerization of the former into long filament. According to the oligomerization mechanism and ligand specificity, the bacterial STING is categorized into Class I and II. Since mammalian STING protein originated in bacteria, the output of this study provides valuable insights in the innate immunity of human.

[the_background] =>

Stimulator of interferon gene (STING) is a crucial immune sensor which, during viral infection, triggers self-destruction of infected cells in order to contain the infection. Although the signaling pathway is initiated by the binding between STING and c-di-GMP, the exact binding mode of c-di-GMP to bacterial STING and the specific recognition mechanism remain vague. Thus, this study is carried out to investigate the mechanism by determining the crystal structures of bacterial STING/c-di-GMP. It also proposes that Class II bacterial STING, which recognizes 3’3’-cGAMP more favorably, is in the evolutionary transition from c-di-GMP-dependent signaling in bacteria to 2’3’-cGAMP-dependent signaling in eukaryotes. Other than facilitating future STING-related studies, this research complements the existing knowledge base for human’s innate immune signaling.

[the_sdg_impact] =>

STING plays an important role in innate immunity as an essential mediator and inducer. Thus, to speed up the advance of research related to human immune system, a more in-depth understanding of mammalian STING protein (which originated in bacteria) is required. By shedding light on the crucial mechanisms involved in human immune system, this study fulfils UNSDG 3: Good Health & Well-Being.

[article_url] => https://www.nature.com/articles/s41467-021-26583-3 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Crystal-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18342642_1660546534.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41467-021-26583-3 [original_article_reference_fields] => Array ( [publication_title] => Crystal structure and functional implication of bacterial STING [journal_title] => Nature Communications [publisher] => Springer Nature [year] => January 2022 [subject] => Medical; Drug Development ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/lvWQi0GqkSM [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/05.mp4_snapshot_00.00_2022.10.26_14.41.56.jpg ) ) [23] => WP_Post Object ( [ID] => 34212 [post_author] => 154 [post_date] => 2022-08-07 20:44:00 [post_date_gmt] => 2022-08-07 12:44:00 [post_content] => [post_title] => Role of Exosomal PD-1 in Anti-Tumor Activity and Attenuation of Immune Suppression [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => role-of-exosomal-pd-1-in-anti-tumor-activity-and-attenuation-of-immune-suppression [to_ping] => [pinged] => [post_modified] => 2022-12-08 11:54:22 [post_modified_gmt] => 2022-12-08 03:54:22 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34212 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/PARG.png [researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung [researchers_second_profile] => https://orcid.org/0000-0002-6705-2521 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => tumor cell; immune checkpoint; T lymphocyte; effector T cell; triple negative breast cancer; tumor infiltrating lymphocyte; t cell; Triple-negative breast cancer; transmission electron microscopy; extracellular vesicles; Programmed cell death 1; programmed death-ligand 1; cell death; tumor-infiltrating lymphocytes [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study discovered the potential of exosomal membrane-bound PD-1 (Exo-PD-1) in enhancing the cytotoxic activity of T cells against tumor cells and, simultaneously, attenuating immune suppression in triple-negative breast cancer (TNBC). Upon activation, Exo-PD-1 released by T cells were actively involved in two modes of PD-L1-blockade anti-tumor action, i.e. remotely binding to exosomal PD-L1 and directly binding to PD-L1 on tumor-cell surface. The Exo-PD-1 binding on the tumor-cell surface induced clathrin-mediated endocytosis (CME) of PD-L1. Other than creating an entry point for Exo-PD-1 to enter the TNBC cells, CME of PD-L1 also reduced the amount of surface PD-L1 available during subsequent direct interaction between T cells and tumor cells. The protective role of Exo-PD-1 against the anti-tumor immune dysfunction induced by PD-L1 in TNBC has been confirmed by in vitro and in vivo studies. As part of the expansion of research scope, future studies ought to examine whether the tumor-infiltrating lymphocytes (TILs) markers of T cell apoptosis and exhaustion are contained by T cell-derived exosomes, and whether they bear similar immune function to that of Exo-PD-1 in fighting tumor.

[the_background] =>

Programmed cell death protein 1 (PD-1) is a protein on the surface of T and B cells. Although PD-1 is essential in preventing autoimmune diseases, it also prevents cancer cells from being killed. In contrast, the expression of PD-1 showed positive correlation to the survival rate of patients with triple-negative breast cancer (TNBC). These contradicting yet intriguing observations made scientists wondered if the PD-1 on T cells comprises uncovered potential associated to the inhibition of cancer cells. Meanwhile, past studies also reported that exosomes derived from T lymphocytes were involved in the regulation of immune reaction. Upon investigating the role of T cells-derived exosomes in suppressing TNBC, this research elucidated how exosomal PD-1 protects against the anti-tumor immune dysfunction induced by PD-L1 in TNBC. Notably, this discovery may lead to the development of therapeutic strategies which enhance cytotoxic activity against tumor cells and attenuate immune suppression simultaneously.

[the_sdg_impact] =>

As long as cancers exist, 10 million lives are lost globally each year and this number can be lowered only by more effective therapeutic strategies. With the proven potential of Exo-PD-1 in treating triple-negative breast cancer (TNBC), promising cancer therapies can be developed based on the modification of exosome surface. Moreover, the discovery of this study also proves the importance of immune suppression attenuation in fighting cancers (UNSDG 3: Good Health & Well-Being).

[article_url] => https://www.nature.com/articles/s41388-021-01896-1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Suppression.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18142672_1659876063.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41388-021-01896-1 [original_article_reference_fields] => Array ( [publication_title] => Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer [journal_title] => Oncogene [publisher] => Springer Nature [year] => June 2021 [subject] => Medical; Cancer; Immunity ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/OjVFFdS2TIo [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/CMU-2022-14.mp4_snapshot_00.00_2022.10.26_14.59.34.jpg ) ) [24] => WP_Post Object ( [ID] => 34198 [post_author] => 154 [post_date] => 2022-08-07 20:32:29 [post_date_gmt] => 2022-08-07 12:32:29 [post_content] => [post_title] => Osteoblastic Prostate Cancer Migration Suppressed by Melatonin [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => osteoblastic-prostate-cancer-migration-suppressed-by-melatonin [to_ping] => [pinged] => [post_modified] => 2022-11-05 15:20:26 [post_modified_gmt] => 2022-11-05 07:20:26 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34198 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TANG, Chih‐Hsin (湯智昕) [researchers_position] => Department of Pharmacology, School of Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/Melatonin3.png [researchers_profile] => https://orcid.org/0000-0002-7113-8352 [researchers_second_profile] => https://www.researchgate.net/scientific-contributions/Chih-Hsin-Tang-38993039 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Quantitative real‐time polymerase chain reaction; integrin; advanced prostate cancer; lung cancer; Gleditsia sinensis; Fluorescein isothiocyanate; G‐protein coupled receptor; metastatic; protein kinase C; messenger RNA [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study reported the pathway underlying how melatonin suppresses the metastatic potential of osteoblastic prostate cancer. The pathway started with the binding of melatonin to MT1 receptor which was crucial in conveying the downstream effects of melatonin. After that, the phosphorylation of FAK, c‐Src and NF‐κB was decreased, inhibiting the integrin α2β1 expression as well as osteoblastic prostate cancer migration. The pathway was revealed via in vitro studies using osteoblastic prostate cancer cell line C4‐2. Preclinical trials can be carried out in the future to explore the possibilities of developing a cancer therapy based on this discovery.

[the_background] =>

Prostate cancer has been identified as a cause of osteoblastic bone metastasis. This indicated that patients with prostate cancer are also facing a high risk of metastatic bone disease. Meanwhile, strong evidence implied the direct involvement of receptors integrins α2β1 in prostate cancer bone metastasis due to their potential in prostate cancer cell progression, migration, and invasion. On the other hand, besides exhibiting antitumor activity, melatonin was actively involved in antimetastatic activity in osteolytic prostate cancer cells as well as osteoclastogenesis inhibition. However, the potential and mechanism of melatonin in inhibiting the migratory and invasive properties of osteoblastic prostate cancer cells remain ambiguous. Thus, this study aimed to investigate the underlying mechanism of how melatonin hinders the motility human prostate cancer cells and the metastatic in osteoblastic prostate cancer cells. The findings confirmed the therapeutic potential of melatonin for prostate cancer bone metastases, paving a path to the design of high-efficacy therapeutic strategies.

[the_sdg_impact] =>

Metastatic bone disease is a severe collateral damage due to cancers and 84% of deaths were due to prostate cancer. There are approximately 268,000 new cases of prostate cancer reported yearly in United States, indicating the high risks of metastatic bone disease. Hence, while focusing on cancer therapies, attention should also be allocated to the treatment of metastatic bone. By demonstrating the efficacy of melatonin in inhibiting the metastatic potential of osteoblastic prostate cancer, this study fulfils UNSDG 3: Good Health & Well-Being.

[article_url] => https://onlinelibrary.wiley.com/doi/10.1111/jpi.12793 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Melatonin.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18142439_1659875237.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1111/jpi.12793 [original_article_reference_fields] => Array ( [publication_title] => Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression [journal_title] => Journal of Pineal Research [publisher] => Wiley Publishing [year] => February 2022 [subject] => Medical; Metastatic Bone Disease; Melatonin ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/uRpEHHqE2V0 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/13.mp4_snapshot_00.00_2022.10.26_14.57.58.jpg ) ) [25] => WP_Post Object ( [ID] => 34187 [post_author] => 154 [post_date] => 2022-08-07 14:09:59 [post_date_gmt] => 2022-08-07 06:09:59 [post_content] => [post_title] => Treating Psychiatric Disorders and Type 2 Diabetes through Their Comorbidity [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => treating-psychiatric-disorders-and-type-2-diabetes-through-their-comorbidity [to_ping] => [pinged] => [post_modified] => 2022-11-14 10:33:37 [post_modified_gmt] => 2022-11-14 02:33:37 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34187 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WANG, Shi-Heng (王世亨) [researchers_position] => Interdisciplinary Freshmen Program of Public Health, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile] => https://www.researchgate.net/profile/Shi-Heng-Wang [researchers_second_profile] => https://orcid.org/0000-0002-8466-2698 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => psychotic disorder; environmental factor; Depression; Adjusted odds ratio; genome-wide association study; Diabetes; Principal component; Comorbidity; East Asian population; family history; linkage disequilibrium major depressive disorder; polygenic risk score; bipolar disorder; familial aggregation; schizophrenia; Psychiatric Genomics Consortium [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Based on a cohort of 105,184 participants, this study disclosed the underlying mechanisms of the comorbidity between psychiatric disorders and type 2 diabetes. A family history of type 2 diabetes was associated with family history of all three common psychiatric disorders i.e. schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD). Compared to paternal type 2 diabetes, maternal type 2 diabetes demonstrated a higher strength of association with SCZ family history, indicating that women demonstrate a more predominant effect of family history of type 2 diabetes on SCZ than men. Higher genetic loading for SCZ was associated with a lower risk of type 2 diabetes in women but not in men. This suggests that gender could potentially alter the genetic effect on human diseases. On the other hand, higher genetic loading for MDD was associated with a higher risk of type 2 diabetes. Although familial aggregation was reported between type 2 diabetes and BPD, there is a lack of a polygenic association between them probably due to a role of environmental factors in the mechanisms. Results also showed that the polygenic effect of SCZ on type 2 diabetes may be partly mediated by obesity and the polygenic effect of MDD on type 2 diabetes may be partly mediated by obesity or smoking. Future studies may replicate this approach on participants of other ancestries (besides Taiwanese) to explore the outcomes.

[the_background] =>

The comorbidity between psychiatric disorders and type 2 diabetes has been proven and this implied the importance to examine its underlying mechanism. Moreover, the familial aggregation of type 2 diabetes and common psychiatric disorders also suggested an influence of shared environmental factors or genetic background. Further studies showed that the association was mainly due to genetic background, especially in female. Meanwhile, the influence of sex differences was highlighted through the difference in prevalence of type 2 diabetes in the mothers and fathers of those with psychosis. Hence, this study investigated the underlying mechanisms of the comorbidity between psychiatric disorders and type 2 diabetes by examining familial aggregation and testing for polygenic overlap based on a molecular approach. For the first time, polygenic loading was applied for common psychiatric disorders to predict type 2 diabetes in Asia with the largest sample size to-date. The output provides crucial insights indicating the needs for therapies and preventive plans to address the initial development of type 2 diabetes and its comorbidity with psychiatric disorders.

[the_sdg_impact] =>

Comorbidity is associated with degrading health, higher complexity clinical management, and higher health care costs. Based on the proven comorbidity between psychiatric disorders and type 2 diabetes, depression should be diagnosed and treated proactively as the physical complications of diabetes that are commonly prioritized. This will directly lower the number of cases for both depression and type 2 diabetes. By understanding the underlying mechanisms of the comorbidity, high-efficacy therapeutic strategies can be planned to lower the risks for both diseases (UNSDG 3: Good Health & Well-Being).

[article_url] => https://link.springer.com/article/10.1007/s00125-022-05665-x [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Comorbidity.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18137574_1659852225.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s00125-022-05665-x [original_article_reference_fields] => Array ( [publication_title] => Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes [journal_title] => Diabetologia [publisher] => Springer Nature [year] => February 2022 [subject] => Medical; Diabetes ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/myX9EYKcI7U [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/CMU-2022-12.mp4_snapshot_00.00_2022.10.26_14.55.45.jpg ) ) [26] => WP_Post Object ( [ID] => 34176 [post_author] => 154 [post_date] => 2022-08-07 13:40:17 [post_date_gmt] => 2022-08-07 05:40:17 [post_content] => [post_title] => Promoted Repair of DNA Double-Strand Break by MRNIP [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => promoted-repair-of-dna-double-strand-break-by-mrnip [to_ping] => [pinged] => [post_modified] => 2022-12-08 11:49:20 [post_modified_gmt] => 2022-12-08 03:49:20 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34176 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/PARG.png [researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung [researchers_second_profile] => https://orcid.org/0000-0002-6705-2521 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => RAD50; MRE11; NBS1; phase separation; colorectal cancer; intrinsically disordered region; nonhomologous end joining; double-strand breaks; ataxia telangiectasia mutated; MRN complex; adenosine triphosphate; homologous recombination' fluorescence recovery after photobleaching; Escherichia coli [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Via in vitro and in vivo studies, this study discloses the underlying mechanism of DNA double-strand break (DSB) repair carried out by MRE11/RAD50/NBS1 (MRN) complex interacting protein (MRNIP). In intrinsically disordered region, the MRNIP forms condensates which then concentrates MRN complex into liquid-like droplets. When DSBs are formed and sensed, the MRNIP condensates proceed swiftly to the damaged DNA and promote the binding of damaged DNA to the concentrated MRN complex. This results in the autophosphorylation of ataxia telangiectasia mutated (ATM) followed by an accelerated DNA damage response and DSB end resection, promoting the homologous recombination (HR)-mediated DSB repair. Meanwhile, compared to normal rectum tissues, lower MRNIP expression is observed in radiation proctitis tissues. This implies that targeting MRNIP condensates could help to sensitize tumor cells to radiotherapy and lead to the development of radiation proctitis. In order to complement the existing findings, the authors are looking forward to the direct uncovering of the pathway underlying the impact of MRNIP condensates on MRN-mediated DSB sensing.

[the_background] =>

The repair of DNA double-strand breaks (DSBs) is no doubt a critical process to maintain the sustainability of organisms. Defective DSBs repair is very likely to cause devastating consequences such as cancer, embryonic death, and neurological disorders. In DSBs repair, the MRE11/RAD50/NBS1 (MRN) complex acts as a sensor towards DSBs and also an initiator of DNA damage responses. However, when DSBs is formed, it is still elusive with regards to how the MRN complex senses and binds to DNA rapidly. In the mean time, liquid-liquid phase separation (LLPS) is a process whereby molecules condense into a dense phase (high concentrated liquid droplets) whilst the remaining solution forms a dilute phase. Various studies associated LLPS to the repair of DNA damage and this indicated that LLPS might play a crucial role in DSBs repair. Therefore, an international collaboration with Sun Yat-sen University Cancer Center (China) and Sun Yat-sen University (China) took place to conduct an in-depth investigation on the role of MRNIP condensate in regulating HR-mediated DSB repair as well as the impact of LLPS on the function of MRNIP. The output of this study is an essential reference for future research which target to overcome diseases related to defective DSBs repairs.

[the_sdg_impact] =>

DNA DSBs, the most severe type of DNA damage, leads to apoptosis, gene mutation, and carcinogenesis if left unattended. As an effort to overcome defective DNA DSBs repair, a strong fundamental understanding about the relevant underlying mechanisms must be acquired. The pathway unveiled in this study provides significant insights on the pathway of DSBs repair and, thus, this study is very well-aligned with UNSDG 3: Good Health & Well-Being.

[article_url] => https://www.nature.com/articles/s41467-022-30303-w [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/MRNIP.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18137379_1659850636.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41467-022-30303-w [original_article_reference_fields] => Array ( [publication_title] => MRNIP condensates promote DNA double-strand break sensing and end resection [journal_title] => Nature Communications [publisher] => Springer Nature [year] => May 2022 [subject] => Medical; Biomedical Sciences; DNA ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/StEIb2bCXjc [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/CMU-2022-10.mp4_snapshot_00.00_2022.10.26_14.51.02.jpg ) ) [27] => WP_Post Object ( [ID] => 34165 [post_author] => 154 [post_date] => 2022-08-07 13:28:10 [post_date_gmt] => 2022-08-07 05:28:10 [post_content] => [post_title] => Overcoming Neurodegenerative Diseases Through Autophagy Initiation by Pridopidine [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => overcoming-neurodegenerative-diseases-through-autophagy-initiation-by-pridopidine [to_ping] => [pinged] => [post_modified] => 2022-11-05 15:11:07 [post_modified_gmt] => 2022-11-05 07:11:07 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34165 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WANG, Shao-Ming (王紹銘) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0003-1479-9100 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => autophagy; guide RNA; E. coli; sigma receptor; Huntington disease; POM121; citrate synthase; Alzheimer disease; nuclear pore; c9orf72; nuclear pore complex; SIGMAR1; mouse model; sclerosis [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study reveals the signaling pathway underlying how pridopidine acts as an agonist in promoting autophagy for neuron protection. When a motor neuron is under pathological threats, pridopidine dissociates chaperone protein SIGMAR1 from HSPA5, allowing SIGMAR1 to proceed to the nuclear pore to chaperone nucleoporin POM121. Then, POM121 recruits KPNB1 so as to create an effective in-bound transportation of TFEB (from cytosol into nucleus), which is crucial for the initiation of autophagy. For the first time, the impact of SIGMAR1 agonists and antagonists on the chaperone activity of SIGMAR1 is elucidated, proving that the SIGMAR1 is a ligand-regulated chaperone. Results indicate that, with the presence of chaperone, the structural nucleoporin POM121 also serves as a signaling molecule which enables TFEB-mediated autophagy. Notably, pridopidine is able to effectively protect motor neuron NSC34 against H2O2-induced toxicity expressing the pathogenic (G4C2)288 repeat. In the absence of pridopidine in transfected NSC34 motor neuron, hexanucleotide (G4C2)RNA expansion (HRE) disrupts TFEB transport by hindering the interaction between SIGMAR1 and POM121. By complementing these discoveries with the ongoing clinical development of pridopidine, future studies may focus on designing a higher-efficacy therapy to treat neurodegenerative diseases.

[the_background] =>

Neurodegenerative diseases, such as Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), are closely related to impairments in autophagy. In ALS-frontotemporal lobar degeneration (ALS-FTD), autophagy is disrupted due to the defective transportation of transcription factor TFEB from the cytosol into the nucleus. Hexanucleotide (G4C2)RNA expansion (HRE) is accountable for the impairment but the exact molecular pathway involved has not been reported yet. Meanwhile, although the chaperone protein SIGMAR1 plays a pivotal role in autophagy, the underlying mechanism was ambiguous. Thus, this research aims to answer these uncertainties and also to examine the mechanism underlying the neuroprotective effect of pridopidine. The study outcome indicates that, by targeting the SIGMAR1, a pharmacological approach could potentially be designed to overcome diseases related to autophagy impairment.

[the_sdg_impact] =>

Millions of people suffer from neurodegenerative diseases globally. In United States, approximately 6 million and 1 million people are reported to be the victims of Alzheimer’s disease and Parkinson’s disease, respectively. These alarming figures can possibly be reduced by therapies which target the chaperone protein SIGMAR1. By explaining how pridopidine activates SIGMAR1, this research paves a clear direction which facilitates the development of therapies to treat neurodegenerative diseases (UNSDG 3: Good Health & Well-Being).

[article_url] => https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2063003 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Neurodegenerative-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18137253_1659849687.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1080/15548627.2022.2063003 [original_article_reference_fields] => Array ( [publication_title] => Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine [journal_title] => Autophagy [publisher] => Taylor & Francis Online [year] => May 2022 [subject] => Medical; Neurodegenerative Diseases ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/4tMJ9H15MbM [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/09.mp4_snapshot_00.00_2022.10.26_14.49.31.jpg ) ) [28] => WP_Post Object ( [ID] => 34151 [post_author] => 154 [post_date] => 2022-08-07 13:10:50 [post_date_gmt] => 2022-08-07 05:10:50 [post_content] => [post_title] => Reprogrammed Tc17 Cells: Signalling Pathway & Cancer Treatment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => reprogrammed-tc17-cells-signalling-pathway-cancer-treatment [to_ping] => [pinged] => [post_modified] => 2022-11-14 10:26:32 [post_modified_gmt] => 2022-11-14 02:26:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34151 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YEN, Hung-Rong (顏宏融) [researchers_position] => School of Chinese Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/Tc17-3.jpg [researchers_profile] => https://www.researchgate.net/profile/Hung-Rong-Yen [researchers_second_profile] => https://orcid.org/0000-0002-0131-1658 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => adoptive cell therapy; IL-4; Fas ligand; IL-12; CD8 T-cell; IL-17; CD8 + T cell; cytotoxic T lymphocytes; NY-ESO-1; IL-23; colorectal cancer [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study reports a novel signalling pathway which converts IL-17-producing CD8+ T cells (Tc17) to IFN-γ producers, leading to enhanced antitumour activity and cytotoxicity of Tc17 cells. The pathway is initiated by IL-4 followed by PI3K/AKT signalling which induces the expression of Eomes and upregulates T-cell receptor-associated transmembrane adaptor 1 (TRAT1) in Tc17 cells. The upregulation of TRAT1 then promotes IL-4-induced T-cell receptor (TCR) stabilization and Tc17 cytotoxicity. IL-4, besides acting as an inducer, is capable of promoting Tc17 cells expansion to achieve higher antitumour potential. On top of these findings, a novel ex vivo procedure is proposed to reprogramme Tc17 extracted from human peripheral blood mononuclear cells (PBMC) in order to be applied in adoptive cell therapy (ACT) for cancer patients. By having enhanced cytotoxicity, the novel ACT could potentially treat a wide spectrum of cancers.

[the_background] =>

Immune effector cell (IEC) therapy primarily involves the use of one’s immune system to treat cancer in his/her own body. Despite its proven potential, there is a huge room for development as the recently applied IEC strategies induce acute but short responses. IL-17-producing CD8+ T cells (Tc17) has been identified as a promising candidate for IEC therapy for its ability to be reprogrammed as cytotoxic anti-tumour effectors. However, Tc17-based IEC is yet to be ready due to the limited knowledge on the factors affecting Tc17 reprogramming and the mechanisms underlying its cytotoxicity promotion. Thus, upon discovering the answers to these uncertainties, this study has taken extra miles to establish a feasible procedure to expand Tc17 from peripheral blood of cancer patients. The research outcome creates a profound impact in oncology by enhancing the applicability and efficacy of Tc17-based IEC therapy.

[the_sdg_impact] =>

With more than 100 types of cancer reported, the continuous development of immunotherapy is crucial to uphold the survival rate of cancer patients. The discovery of a potent Tc17-based adoptive cell therapy (ACT) serves not only as a possible cure, but also as robust knowledge base for future research. By disclosing the signalling pathway involved, this study facilitates the development of new cancer therapies (UNSDG 3: Good Health & Well-Being).

[article_url] => https://onlinelibrary.wiley.com/doi/10.1111/imm.13473 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Tc17-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18136911_1659847584.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1111/imm.13473 [original_article_reference_fields] => Array ( [publication_title] => Adoptive transfer of IL-4 reprogrammed Tc17 cells elicits anti-tumour immunity through functional plasticity [journal_title] => Immunology [publisher] => Wiley Publishing [year] => March 2022 [subject] => Medical; Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/jPsLkJsXFMk [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/CMU-2022-08.mp4_snapshot_00.00_2022.10.26_14.47.29.jpg ) ) [29] => WP_Post Object ( [ID] => 34137 [post_author] => 154 [post_date] => 2022-08-07 12:31:53 [post_date_gmt] => 2022-08-07 04:31:53 [post_content] => [post_title] => PKCδ/SGLT1 Co-targeting for Improved Therapeutic Efficacy of EGFR TKIs in NSCLC Patients [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => pkc%ce%b4-sglt1-co-targeting-for-improved-therapeutic-efficacy-of-egfr-tkis-in-nsclc-patients [to_ping] => [pinged] => [post_modified] => 2022-12-08 11:44:54 [post_modified_gmt] => 2022-12-08 03:44:54 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34137 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUANG, Wei-Chien (黃偉謙) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/EGFR.png [researchers_profile] => https://www.researchgate.net/profile/Wei-Chien-Huang [researchers_second_profile] => https://orcid.org/0000-0001-6467-8716 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => epidermal growth factor receptor; triple-negative breast cancer; glucose uptake; positron emission tomography; PKCδ; epithelial-mesenchymal transition; tyrosine kinase inhibitor; non-small cell lung cancer; glucose; transporter; progression-free survival [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study provides strong evidence that glucose metabolic re-wiring may contribute to the development of acquired resistance of non-small cell lung cancer (NSCLC) to epidermal growth factor receptors tyrosine kinase inhibitor (EGFR TKIs). The findings suggest that NSCLC cells with acquired EGFR TKI resistance are more tolerant to low glucose-induced autophagy following a metabolic shift to higher glucose uptake and glycolysis activity due to upregulation of active sodium/glucose co-transporter 1 (SGLT1) by Thr678-phosphorylated EGFR, in a protein kinase C delta (PKCδ)- dependent manner. Therefore, the combination of SGLT1 inhibitor with EGFR TKIs shows a synergetic effect in reducing tumor growth and glucose uptake in vitro and in vivo. Future studies can be conducted to determine if hormone receptors are involved in the regulation of SGLT1 expression in lung cancer tissues.

[the_background] =>

EGFR, a membrane-bound tyrosine kinase receptor, has been found to be a critical oncogene in promoting tumorigenesis, mitogenesis, and tumor progression of various cancer types, including NSCLC. Small molecule tyrosine kinase inhibitors (TKIs) targeting the ATP-binding pocket of the EGFR kinase domain were developed and approved for NSCLCs. However, the secondary EGFR mutations and activations of alternative receptor tyrosine kinases (RTKs) created a bypass track, leading to the failed responses to EGFR TKIs, yet fail to fully account for the development of acquired resistance to these drugs in NSCLC patients. Mounting evidence has proved that EGFR impacts the rewiring of the glucose metabolic network to promote tumor progression in NSCLC. Therefore, this study aims to understand the glucose metabolic re-wiring pathway in NSCLC patients with acquired EGFR TKI resistance. The findings would potentially be used to explore an effective treatment strategy against EGFR TKI resistance.

[the_sdg_impact] =>

Approximately 85% of lung cancers are recognized as NSCLC. Mutations lead to EGFR amplification and overexpression and have been associated with NSCLC progression. Inhibitors targeting EGFR tyrosine kinase activity were used to block the downstream signaling pathway and showed promising therapeutic efficacy. Unfortunately, most patients with NSCLC who are treated with these drugs develop resistance. Much evidence has proved that EGFR promotes tumor progression by rewiring glucose metabolic networks in NSCLC. By identifying the biological mechanisms that associate glucose metabolic re-writing pathway with NSCLC treatment resistance, this study expands the possibility of increasing the effectiveness of the existing treatment. Ultimately, the proposed combination of SGLT1 inhibitor with EGFR TKIs would serve as a new therapeutic strategy to reduce the mortality rate of patients with NSCLC (UNSDG 3: Good Health & Well-Being).

[article_url] => https://www.nature.com/articles/s41388-021-01889-0#Bib1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/EGFR-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18136703_1659846478.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41388-021-01889-0 [original_article_reference_fields] => Array ( [publication_title] => PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs [journal_title] => Oncogene [publisher] => Springer Nature [year] => June 2021 [subject] => Medical; Biomedical Sciences; Lung Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/W9S-NyiHpp8 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/07.mp4_snapshot_00.00_2022.10.26_14.45.48.jpg ) ) [30] => WP_Post Object ( [ID] => 34126 [post_author] => 154 [post_date] => 2022-08-07 12:16:10 [post_date_gmt] => 2022-08-07 04:16:10 [post_content] => [post_title] => Developing High Efficacy Immunotherapy via Casein Kinase 2 Inhibition [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => developing-high-efficacy-immunotherapy-via-casein-kinase-2-inhibition [to_ping] => [pinged] => [post_modified] => 2022-12-08 11:43:39 [post_modified_gmt] => 2022-12-08 03:43:39 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34126 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/PARG.png [researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung [researchers_second_profile] => https://orcid.org/0000-0002-6705-2521 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => programmed cell death 1; E. coli; tumor microenvironment; immune cell; alanine transaminase; protein kinase; t cell; Triple-negative breast cancer; The Cancer Genome Atlas; T-cell receptor; blood urea nitrogen; casein kinase 2; granzyme A; dendritic cell; CD8 alpha; cullin 3; aspartate transaminase; Immune checkpoint blockade [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study unveils an immunotherapeutic approach to treat cancer by avoiding the phosphorylation of programmed cell death ligand 1 (PD-L1) through casein kinase 2 (CK2) inhibition. The inhibition of CK2 leads to degradation of PD-L1 in cancer and dendritic cells (DCs) followed by the activation of T cells by DCs which, in turn, enhances the antitumor activity. In other words, CK2 hinders the antigen-specific T-cell function through phosphorylation of PD-L1. Meanwhile, in preclinical trial, mouse mammary tumor exhibits suppressed growth when treated by a CK2 inhibitor combined with an antibody against T-cell immunoglobulin mucin-3 (Tim-3). Collectively, the outcome indicates that the approach is not only effective on triple-negative-breast-cancer (TNBC), but also applicable for other cancer types, such as lung cancer, prostate cancer, and melanoma. In order to validate this approach, future clinical studies can be conducted to focus on its anti-tumor efficacy in different types of cancer tissues.

[the_background] =>

Casein kinase 2 (CK2) has been proven to be a potential target in treating cancers. Although CK2 is crucial for cell sustainability, its upregulation in all cancers has shown consistent trend in promoting tumor cell growth, leading to poor prognosis. During the inhibition of CK2, significant improvement was observed in the antitumor activity of immune checkpoint receptor blockade using anti–CTLA-4 antibody. This suggests that CK2 inhibition could potentially overcome the ineffectiveness of anti–PD-1/PD-L1 immune checkpoint blockade (ICB) treatment experienced by a substantial amount of cancer patients. Hence, in an international collaboration with the Department of Molecular and Cellular Oncology from The University of Texas MD Anderson Cancer Center (USA), this study aims to investigate the mechanism of PD-L-1 regulation by CK2 and have successfully demonstrated CK2–PD-L1 pathway blockage as a high potential tumor treatment. Since this approach is applicable for various cancer types, it is likely to increase the chances for human to survive cancers.

[the_sdg_impact] =>

Cancer-related researches have been progressing dramatically but many of the potential therapies are effective to only limited types of cancer and patients. Since CK2 inhibition is a high-potential treatment for multiple cancer types, it can be coupled with other effective therapies to achieve better outcome. The output of this study creates a significant milestone in cancers treatment, realizing UNSDG 3: Good Health & Well-Being.

[article_url] => https://aacrjournals.org/cancerres/article-abstract/82/11/2185/699105/Phosphorylation-and-Stabilization-of-PD-L1-by-CK2?redirectedFrom=fulltext [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Phosphorylation-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18136521_1659845483.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1158/0008-5472.can-21-2300 [original_article_reference_fields] => Array ( [publication_title] => Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function [journal_title] => Cancer Research [publisher] => American Association of Cancer Research [year] => June 2022 [subject] => Medical; Biomedical Sciences; Cancer; Immunotherapy ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/tdgzhf2fjeo [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/CMU-2022-06.mp4_snapshot_00.00_2022.10.26_14.43.57.jpg ) ) [31] => WP_Post Object ( [ID] => 34115 [post_author] => 154 [post_date] => 2022-08-07 11:41:37 [post_date_gmt] => 2022-08-07 03:41:37 [post_content] => [post_title] => Inhibition of Glucocorticoid Receptor for Enhanced Anti-Tumor Immunity Against Pancreatic Cancer [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => inhibition-of-glucocorticoid-receptor-for-enhanced-anti-tumor-immunity-against-pancreatic-cancer [to_ping] => [pinged] => [post_modified] => 2022-11-14 09:54:58 [post_modified_gmt] => 2022-11-14 01:54:58 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34115 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/PARG.png [researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung [researchers_second_profile] => https://orcid.org/0000-0002-6705-2521 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => T cell; immunotherapy; tumor cell; fetal bovine serum; immune checkpoint; tumor microenvironment; pancreatic cancer; immune evasion; Cushing syndrome; pancreatic ductal adenocarcinoma; cancer cell; The Cancer; Genome Atlas; clinical trial; granzyme B; progesterone receptor; horseradish peroxidase; phorbol myristate acetate; phosphate-buffered saline; magnetic resonance imaging; cytotoxic T lymphocytes; Chromatin; immunoprecipitation; major histocompatibility complex class I; glucocorticoid response elements; Immune checkpoint blockade; glucocorticoid receptor [graphic_abstract] => [figures] => [video] => [the_novelty] =>

In an international collaboration with the Department of Experimental Radiation Oncology from The University of Texas MD Anderson Cancer Center (USA), this study discovers that glucocorticoid receptor (GR) is a promising target for overcoming pancreatic cancer. Based on animal trials, GR inhibition results in downregulation of programmed death-ligand 1 (PD-L1) and upregulation of major histocompatibility complex class I (MHC-I) in tumor cells. These effects then improve both anti-tumor immunity and response to immune checkpoint blockade (ICB) therapy. Consistent outcomes are also observed in patients with pancreatic ductal adenocarcinoma (PDAC). Meanwhile, clinical GR antagonist mifepristone is able to produce similar results although its anti-tumor effect is not as profound as that of GR inhibition. Nonetheless, the efficacy of the combined therapy of GR inhibition and mifepristone is worth to be tested clinically. In order to move towards materialization, future studies should focus on several scopes including: to determine whether targeting GR sensitizes pancreatic cancer to chemotherapies through immune regulation, to investigate the outcome of applying the same therapy on other types of cancer, and to optimize the dosage of GR antagonist mifepristone so as to enhance its efficacy with minimum toxicity.

[the_background] =>

To date, an effective treatment for pancreatic cancer has yet to be developed. Although chemotherapy and radiotherapy are the common therapies being used to treat patients of pancreatic cancer, they are very likely to cause severe deterioration in patients. Furthermore, major driver genes for pancreatic cancer (e.g. KRAS, TP53, CDKN2A, and SMAD4) have not been approved by FDA to be applied as clinical therapies yet. Despite showing positive effects on other cancer types, immune checkpoint blockade (ICB) therapies were not effective for pancreatic cancer, regardless of whether being applied alone or combined with other therapies (i.e. chemotherapy, radiotherapy, targeted therapy, and vaccination). Glucocorticoid receptor (GR) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. Since the anti-tumor potential of GR has been demonstrated in past research, this study examines how GR can be part of the strategy to overcome pancreatic cancer. The output of this study show that GR inhibition is effective in treating pancreatic cancer and a feasible therapy can be derived based on that.

[the_sdg_impact] =>

Pancreatic cancer is projected to become the second leading cause of cancer-related death by 2030. Pancreatic ductal adenocarcinoma (PDAC) patients in the United States show a 5-year survival rate of as low as 6%. These alarming figures imply the urgent need for more effective therapies. As there is a huge room of improvement for the existing therapies of pancreatic cancer, the findings of this study are essential for the development of relevant therapies. By identifying GR as a target, this research contributes to the realization of breakthrough strategies to treat PDAC patients (UNSDG 3: Good Health & Well-being).

[article_url] => https://www.nature.com/articles/s41467-021-27349-7 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Glucocorticoid-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18136174_1659843456.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41467-021-27349-7 [original_article_reference_fields] => Array ( [publication_title] => Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance [journal_title] => Nature Communications [publisher] => Springer Nature [year] => December 2021 [subject] => Medical; Biomedical Sciences; Pancreatic Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/hANmPEhjL30 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/CMU-2022-04.mp4_snapshot_00.08_2022.10.26_14.39.35.jpg ) ) [32] => WP_Post Object ( [ID] => 34101 [post_author] => 154 [post_date] => 2022-08-07 11:26:05 [post_date_gmt] => 2022-08-07 03:26:05 [post_content] => [post_title] => Stronger Anti-Tumour Immunity in Colorectal Cancers via Inhibition of Protein Phosphatase 2A [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => stronger-anti-tumour-immunity-in-colorectal-cancers-via-inhibition-of-protein-phosphatase-2a [to_ping] => [pinged] => [post_modified] => 2022-12-08 11:39:19 [post_modified_gmt] => 2022-12-08 03:39:19 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34101 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Shih-Chieh (洪士杰) [researchers_position] => Integrative Stem Cell Center, Department of Orthopedics, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/PP2A3.png [researchers_profile] => https://stm.sciencemag.org/content/13/583/eabc2823 [researchers_second_profile] => https://orcid.org/0000-0002-4098-5225 (Heng-Hsiung Wu); https://orcid.org/0000-0002-3117-931X (Wen-Hwa Lee) ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Gene Expression Omnibus; loss of heterozygosity; microsatellite instability; cytotoxic T cell; retinoblastoma protein; dendritic cells; Tissue microarray; Methylation-specific PCR; histone deacetylase; next-generation; sequencing; MLH1; phosphate-buffered saline; immune checkpoint blockade; protein phosphatase; mismatch repair deficiency; gene set enrichment analysis; polyvinylidene fluoride; T cell receptor; colorectal cancer [graphic_abstract] => [figures] => [video] => [the_novelty] =>

To better understand microsatellite-instable (MSI) tumours as a key to overcoming colorectal cancers (CRCs), this study shows that the inhibition of protein phosphatase 2A (PP2A) could lead to the loss of DNA mismatch repair (MMR) genes (i.e. causing MMRd), resulting in the conversion of microsatellite-stable (MSS) into MSI tumours. The PP2A inhibition brings about the conversion via two different pathways, i.e. by increasing retinoblastoma protein phosphorylation and by increasing histone deacetylase (HDAC)2 phosphorylation. Moreover, the inactivation of PP2A also enhances MSI tumours’ response to immune checkpoint blockade (ICB). In short, PP2A inhibition initiates neoantigen production, increases cytotoxic T cell infiltration and improves response to ICB. These results were obtained from animal models as well as human cancer cell lines and tissue array. In order to materialise an effective therapy based on the findings, future studies should investigate the effect of mRNA dysregulation or mutations of the genes on the adaptive and acquired resistance to ICB.

[the_background] =>

15% of sporadic colorectal cancers (CRCs) are closely associated to microsatellite-instable (MSI) tumours with defective DNA mismatch repair (MMR). Compared to microsatellite-stable (MSS) tumours, focusing on the mechanism of MSI tumours development is a more practical strategy as MSI tumours exhibit better prognosis and response to immune checkpoint blockade (ICB) (i.e. a type of immunotherapy drug). Studies show that both CRC and non-CRC patients with MMR deficiency (MMRd) have better responses to programmed death 1 (PD-1) ICB therapy. These findings support the need to focus on MSI tumours even though the molecular mechanisms have yet to be confirmed. Meanwhile, although protein phosphatase 2A (PP2A)-targeted anti-tumour therapies have received significant attention, the anti-tumour effects of activating or inhibiting PP2A activity is uncertain. Furthermore, the number of studies on PP2A’s tumour-intrinsic signaling and response to ICB are still scanty. Therefore, this research aims to achieve two goals, i.e. to investigate the mechanism of MMRd and to examine the effect of PP2A inhibition on the conversion of MSS to MSI tumours. Other than solving the previously unanswered questions, the output of this study provides valuable insights to the possible feasible ways to overcome cancers by focusing on PP2A.

[the_sdg_impact] =>

In 2020, CRC was the second most common cause of cancer death worldwide, causing almost 1 million deaths. It was the third most common cancer in men but the second most common cancer in women, after breast cancer. The in-depth discussion on the potential of PP2A inhibition in fighting CRC opens up an avenue for the realisation of new treatments for CRC. With better knowledge base and more effective therapy, tremendous amount of CRC patients with will stand higher chance to survive (UNSDG 3: Good Health & Well-being).

[article_url] => https://www.nature.com/articles/s41467-021-27620-x [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/PP2A.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18136035_1659842502.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41467-021-27620-x [original_article_reference_fields] => Array ( [publication_title] => Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response [journal_title] => Nature Communications [publisher] => Springer Nature [year] => December 2021 [subject] => Medical; Orthopedics; Colorectal Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/nrcQ3lutcMc [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/03.mp4_snapshot_00.00_2022.10.26_14.35.50.jpg ) ) [33] => WP_Post Object ( [ID] => 34081 [post_author] => 154 [post_date] => 2022-08-07 11:02:28 [post_date_gmt] => 2022-08-07 03:02:28 [post_content] => [post_title] => Dual-Action Liver Cancer Therapy via Co-Inhibition of PARG & PD-1 [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => dual-action-liver-cancer-therapy-via-co-inhibition-of-parg-pd-1 [to_ping] => [pinged] => [post_modified] => 2022-12-08 11:37:19 [post_modified_gmt] => 2022-12-08 03:37:19 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=34081 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences; Center for Molecular Medicine; Research Center for Cancer Biology; Drug Development Center, D2 China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/PARG.png [researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung [researchers_second_profile] => https://orcid.org/0000-0002-6705-2521 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => c-Myc; immunotherapy; PD-1; cell cycle checkpoint; The Cancer Genome Atlas; mismatch repair; Hepatocellular carcinoma; quantitative RT-PCR; DDB1; dna replication; PARG [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/08/1-s2.0-S0168827822000721-ga1.jpg [figures] => [video] => [the_novelty] =>

As part of the effort to develop an effective therapy for liver cancer hepatocellular carcinoma (HCC), this study revealed the role of poly (ADP-ribose) glycohydrolase (PARG) enzyme in the development of HCC. PARG acted as a main culprit for the spread of HCC through the newly discovered PARG/DDB1/c-Myc signaling pathway which implies PARG as a potential biomarker for HCC treatment. More importantly, when PARG was inhibited, improved condition was observed in mice undergoing anti-PD-1 anticancer drug therapy. The results indicate that the inhibition of both PARG and PD-1 is a highly-effective dual-action therapy for HCC. With the promising output, future clinical trials can be conducted to determine and to optimize the efficacy of the dual-action therapy.

[the_background] =>

Despite being actively involved in various cellular activities (e.g. DNA replication, transcription, and apoptosis), PARG was also reported to cause tumor growth. Furthermore, positive outcomes were observed when PARG-targeted strategy was implemented in cancer therapies. All this led to unanswered questions related to the exact regulatory mechanism of PARG especially in the growth of cancer tissues. Hence, an international collaboration with the Department of Liver Surgery and Transplantation of Fudan University (Shanghai) took place to examine the physiological roles and signaling pathway of PARG in HCC progression. Co-inhibition of PARG and PD-1 was reported for the first time as an effective dual-action strategy for patients with HCC. These findings showed that other combination strategies involving PARG inhibition could possibly lead to effective treatment for other types of cancer.

[the_sdg_impact] =>

Within the wide spectrum of cancer, hepatocellular carcinoma (HCC) alone has caused more than 600,000 deaths each year globally. Since both chemotherapy and radiotherapy often cause relapse in patients, immunotherapy via PARG-inhibition could potentially minimize the side-effects while increasing the chance for recovery. Thus, this study contributes to the fulfilment of UNSDG 3: Good Health & Well-being by sharing profound discoveries in the research and development of cancer therapies.

[article_url] => https://www.sciencedirect.com/science/article/pii/S0168827822000721 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/PARG2-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/08/18135801_1659840675.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.jhep.2022.01.026 [original_article_reference_fields] => Array ( [publication_title] => PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy [journal_title] => Journal of Hepatology [publisher] => Elsevier [year] => July 2022 [subject] => Medical; Biomedical Sciences; Liver Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/c1qJ1wapkBI [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/08/01.mp4_snapshot_00.00_2022.10.24_17.38.18.png ) ) [34] => WP_Post Object ( [ID] => 33964 [post_author] => 154 [post_date] => 2022-07-14 16:14:45 [post_date_gmt] => 2022-07-14 08:14:45 [post_content] => [post_title] => Tourists Retention by Place Attachment, Emotional Experience & Religious Affiliation [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => tourists-retention-by-place-attachment-emotional-experience-religious-affiliation [to_ping] => [pinged] => [post_modified] => 2022-07-14 16:14:45 [post_modified_gmt] => 2022-07-14 08:14:45 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33964 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PATWARDHAN, Vidya [researchers_position] => Centre for Hospitality and Tourism Research, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Restaurants.png [researchers_profile] => https://www.researchgate.net/profile/Vidya-Patwardhan-3 [researchers_second_profile] => https://orcid.org/0000-0003-4850-5537 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Place attachment; Place identity; Place dependence; Emotional experience; Religious destination loyalty; Religious affiliation [graphic_abstract] => [figures] => [video] => [the_novelty] =>

In the context of religious tourism destinations, this study elucidated that the effect of visitors’ place attachment on destination loyalty is given rise by their on-site emotional experience (a mediator). Meanwhile, the extent of visitors’ religious affiliation (a moderator) determined how much place attachment and emotional experience would affect destination loyalty. Place dependence (a dimension of place attachment) showed an indirect effect on destination loyalty via emotional experience. In comparison to Hindu and Muslim visitors, this effect (moderated by religious affiliation) was strongest among Christian visitors. The data used in this study was obtained from a survey that involved 812 Attur Feast attendees, followed by a series of multiple regression analyses. Future studies may test the consistency of this experimental model by replicating it in contexts involving different religions. In addition, more dimensions of place attachment (e.g., place effect and place social bonding), extra psychological concepts (e.g., emotions and perceived authenticity), and reputation of religious destination can be included as part of the research.

[the_background] =>

Religious festivals are valuable occasions as they embrace customs and beliefs. Most of the festivals are being held at unique locations, fostering a sense of place attachment in the attendees. In turn, place attachment was shown to result in the development of emotional experience. However, an inadequate amount of studies have looked into the effect of place attachment on emotional experience and how this relationship leads to destination loyalty. Besides that, the effect of religious affiliation on those relationships has not been assessed yet. In order to complement the research gap, this study evaluated the role of visitors' place attachment and emotional experience on destination loyalty, with religious affiliation as a moderator within the model. The contribution of the outcome includes facilitating the planning for sustainability of religious events and providing constructive strategies to promote religious festivals and events.

[the_sdg_impact] =>

In 2019, India’s Travel & Tourism GDP contribution grew by 4.9%, the third highest after China and the Philippines. In the following year, it created 31.8 million jobs which contributed to 7.3% of the total employment in the country (source: ibef.org). These data indicate that tourism plays a major role in the livelihood of the people in India. Hence, the government should prioritize the industry by implementing policies to support and enhance tourism. This research sheds light on the influence of emotional experiences and religious affiliation on destination loyalty. Thus, its goal is perfectly aligned with UNSDG8: Decent Work & Economic Growth.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S2211973620301045?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Tourism-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17529914_1657786334.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.tmp.2020.100737 [original_article_reference_fields] => Array ( [publication_title] => Visitors' loyalty to religious tourism destinations: Considering place attachment, emotional experience and religious affiliation [journal_title] => Tourism Management Perspectives [publisher] => Elsevier [year] => October 2020 [subject] => Hospitality and Tourism; Tourists Retention ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [35] => WP_Post Object ( [ID] => 33953 [post_author] => 154 [post_date] => 2022-07-14 16:07:07 [post_date_gmt] => 2022-07-14 08:07:07 [post_content] => [post_title] => Factors Influencing Tourists’ Destination Loyalty [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => factors-influencing-tourists-destination-loyalty [to_ping] => [pinged] => [post_modified] => 2022-07-14 16:07:07 [post_modified_gmt] => 2022-07-14 08:07:07 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33953 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PATWARDHAN, Vidya [researchers_position] => Centre for Hospitality and Tourism Research [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Restaurants.png [researchers_profile] => https://www.researchgate.net/profile/Vidya-Patwardhan-3 [researchers_second_profile] => https://orcid.org/0000-0003-4850-5537 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => place attachment; destination loyalty; emotional solidarity; perceived safety; religious festival; moderated mediation [graphic_abstract] => [figures] => [video] => [the_novelty] =>

What keeps a visitor returning to a festival or tourist destination? In the context of a religious festival, this study demonstrated that visitors’ place attachment is a determinant for destination loyalty and emotional solidarity. Moreover, destination loyalty is positively affected by emotional solidarity. Place attachment also positively affected destination loyalty through emotional solidarity (a mediator). The strength of such effect relied on the visitor level of perceived safety (a moderator) at the festivals. The data collection and sampling involved 813 visitors during the Attur Church Fest in Karkala, India. Structural Equation Modelling (SEM) was used to test the hypotheses. The mediation and moderated mediation effects between the study constructs were tested using Process Macro 4.0. In order to go more in-depth, future studies can include obligatory religious motivations, shared behavior, and shared beliefs as antecedents of destination loyalty and emotional solidarity in a religious context. Furthermore, the influence of visitors’ perceived level of safety in the effect of antecedents on destination loyalty should also be emphasized. Destination managers should promote these festivals as an encounter momentum between host and guest and a sharing space of religious experiences that amplify the authenticity of the place. Publicising these aspects will definitely enhance the footfall (national and international) which in turn is beneficial to increase tourism potential of the region.

[the_background] =>

During religious festivals, place attachment is closely related to emotional solidarity (the degree of closeness between residents and tourists in a destination). Meanwhile, on-spot safety is a critical reason tourists return to the festivals. Although emotional solidarity contributes to a sense of safety, it remains obscure whether perceived safety may moderate the effect between place attachment and destination loyalty via emotional solidarity. Besides that, the effect of place attachment and emotional solidarity on destination loyalty is not investigated. To address the literature gap, this study disclosed how place attachment and emotional solidarity could influence destination loyalty and how perceived safety may moderate these relationships. The outcomes of this research serve as important guidelines for local authorities and festival organizers to implement necessary improvements to retain the loyalty of tourists and attendees.

[the_sdg_impact] =>

In 2020, the GDP contribution of the Indian travel & tourism industry was US$ 121.9 billion. Also, it accounted for 31.8 million jobs, which was 7.3% of the total employment in the country (source: ibef.org). These significant figures indicate that the Indian government should pay attention to enhancing and innovating the industry. By highlighting important theories that can promote development-oriented policies in supporting sustainable tourism, this study materialized UNSDG 8: Decent Work & Economic Growth. In the 2030 Agenda for Sustainable Development SDG target 8.9, aims to “by 2030, devise and implement policies to promote sustainable tourism that creates jobs and promotes local culture and products”. The importance of sustainable tourism is also highlighted in SDG target 12.b. which aims to “develop and implement tools to monitor sustainable development impacts for sustainable tourism that creates jobs and promotes local culture and products”.

[article_url] => https://journals.sagepub.com/doi/full/10.1177/0047287518824157 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Tourists-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17529706_1657785829.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1177/0047287518824157 [original_article_reference_fields] => Array ( [publication_title] => Visitors’ Place Attachment and Destination Loyalty: Examining the Roles of Emotional Solidarity and Perceived Safety [journal_title] => Journal of Travel Research [publisher] => Sage Publishing [year] => February 2019 [subject] => Hospitality and Tourism; Tourists Retention ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [36] => WP_Post Object ( [ID] => 33938 [post_author] => 154 [post_date] => 2022-07-14 15:54:38 [post_date_gmt] => 2022-07-14 07:54:38 [post_content] => [post_title] => Facilitating New Product Development in Restaurant Through Social Capital & Knowledge Sharing [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => facilitating-new-product-development-in-restaurant-through-social-capital-knowledge-sharing [to_ping] => [pinged] => [post_modified] => 2022-07-14 15:54:38 [post_modified_gmt] => 2022-07-14 07:54:38 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33938 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PATWARDHAN, Vidya [researchers_position] => Centre for Hospitality and Tourism Research, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Restaurants.png [researchers_profile] => https://www.researchgate.net/profile/Vidya-Patwardhan-3 [researchers_second_profile] => https://orcid.org/0000-0003-4850-5537 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => New product development; Knowledge sharing intention; External social capital; Internal social capital [graphic_abstract] => [figures] => [video] => [the_novelty] =>

In the context of the high-end restaurant business in India, this study demonstrated that the quality of relationships within the business team (internal social capital, ISC) positively affects the quality of relationships formed with outsiders (external social capital, ESC). This phenomenon was mainly due to the collectivist culture in India, whereby good relationships (cultivated internally and externally) give rise to social support and identity. Despite that, only ISC has a positive impact on the knowledge sharing index (KSI) which, in turn, acted as a driving force for new product development (NPD). The results were obtained by deploying partial least square structural equation modeling to analyze the input data collected from 523 participants from the managerial team of high-end restaurants in India. For future studies, the authors proposed to investigate other determinants of sharing behaviors (e.g., resilience-building capacities, employee engagement, psychological ownership), different types of capital (e.g., financial and human), and other outcomes of knowledge sharing (e.g., customer orientation, creativity performance, and job performance).

[the_background] =>

Innovation and new product development (NPD) are key elements in defining successful hospitality organizations, such as hotels, tour agencies, restaurants, and food and beverage providers. Meanwhile, both internal and external social capital (SC) were seen as reliable predictors of knowledge-sharing behaviors. Despite the confirmed influence of knowledge-sharing behaviors in facilitating service innovation in tourism firms and restaurants, researchers have yet to determine if SC is a determinant of knowledge-sharing intention (KSI) and new product development (NPD). In order to fill up the research gap, this study investigated the impact of both internal and external SC concurrently on restaurant innovation through KSI and NPD. The results acted as a valuable reference for the government to design policies for growing and supporting the restaurant sector.

[the_sdg_impact] =>

The hospitality industry has taken a brutal hit since the COVID-19 pandemic started, and countless restaurants and hotels were forced to close down. In the current recovering stage of this industry, innovative plans are crucial to catch up with the new norm that altered the demand and preferences of consumers. By examining the factors affecting innovation, this research strived to facilitate new product development in restaurants. Thus, it realized UNSDG 8: Decent Work & Economic Growth.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/IJCHM-04-2020-0345/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Restaurants2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17529445_1657785069.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/IJCHM-04-2020-0345 [original_article_reference_fields] => Array ( [publication_title] => The impact of social capital and knowledge sharing intention on restaurants’ new product development [journal_title] => International Journal of Contemporary Hospitality Management [publisher] => Emerald Publishing [year] => September 2020 [subject] => Hospitality and Tourism; Restaurants ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [37] => WP_Post Object ( [ID] => 33924 [post_author] => 154 [post_date] => 2022-07-14 15:40:29 [post_date_gmt] => 2022-07-14 07:40:29 [post_content] => [post_title] => Assessment of Urban Sprawl in Eight Mid-Sized Indian Cities [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => assessment-of-urban-sprawl-in-eight-mid-sized-indian-cities [to_ping] => [pinged] => [post_modified] => 2022-07-14 15:40:29 [post_modified_gmt] => 2022-07-14 07:40:29 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33924 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHETTRY, Vishal [researchers_position] => Manipal School of Architetcure and Planning, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Urban.png [researchers_profile] => https://www.researchgate.net/profile/Thivaharan-Varadavenkatesan [researchers_second_profile] => https://orcid.org/0000-0002-3772-2408 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Urban sprawl index; RS & GIS; Landscape metrics; Mid-sized city; India [graphic_abstract] => [figures] => [video] => [the_novelty] =>

By applying modern research tools like remote sensing (RS) and geographic information system (GIS), this study showed that eight mid-sized Indian cities underwent a rapid outward expansion of built-up areas, with irregular shapes of built-up patches. Furthermore, secondary urban core and urban fringe showed an increasing trend. Despite the uptrends, there was a decline in population density in most cities. Urban sprawl index (USI) was formulated by combining eleven significant variables related to urban sprawl patterns and typologies from open source datasets. Such index can be used in developing and under developed countries where data availability is a major constraint. The urban sprawl index (USI) varied from 20.73 to 11.28 in Thiruvananthapuram Urban Agglomeration (UA) and Dehradun UA.

[the_background] =>

Urban sprawl refers to the expansion of poorly planned, low-density, auto-dependent development, creating high segregation between residential and commercial uses. It causes adverse effects on the environment and biodiversity in India. Although urban growth is likely to take place mainly in mid-sized cities, thorough research emphasizing urban sprawl assessment of mid-sized cities remains scarce. Hence, this study adopted several modern research tools to analyze the spatio-temporal urban sprawl in eight mid-sized Indian cities from regions with different physiography. Besides enriching the database of the urban sprawl index (USI) for future research, the output of this research served as a reliable reference for the local authorities to plan for sustainable urban development.

[the_sdg_impact] =>

Proper urbanization is crucial for the healthy development of the economy, society, and environment of any country. On the other hand, urban sprawl is known to bring the residents and the environment negative consequences, such as water and air pollution, increased traffic fatalities and jams, and loss of agricultural capacity. As the findings of the study serve as a reference to strengthen national and regional development planning, it indirectly contributes to the realization of UN SDG 11: Sustainable Cities & Communities.

[article_url] => https://link.springer.com/article/10.1007/s12524-021-01420-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Urban-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17529117_1657784227.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s12524-021-01420-8 [original_article_reference_fields] => Array ( [publication_title] => Urban Sprawl Assessment in Eight Mid-sized Indian Cities Using RS and GIS [journal_title] => Journal of the Indian Society of Remote Sensing [publisher] => Springer Nature [year] => August 2021 [subject] => Architetcure; Geographic Information System ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [38] => WP_Post Object ( [ID] => 33910 [post_author] => 154 [post_date] => 2022-07-14 15:31:22 [post_date_gmt] => 2022-07-14 07:31:22 [post_content] => [post_title] => Wastewater Management Using Aqueous Two-Phase System (ATPS) [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => wastewater-management-using-aqueous-two-phase-system-atps [to_ping] => [pinged] => [post_modified] => 2022-07-14 15:31:22 [post_modified_gmt] => 2022-07-14 07:31:22 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33910 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => VARADAVENKATESAN, Thivaharan [researchers_position] => Department of Biotechnology, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Wastewater.png [researchers_profile] => https://www.researchgate.net/profile/Thivaharan-Varadavenkatesan [researchers_second_profile] => https://orcid.org/0000-0002-3772-2408 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Aqueous two-phase system; WastewaterProteins; Biomolecules; Wastewater treatment; Phenolic compounds [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study provides an overview of the different applications of the aqueous two-phase system (ATPS) in recovering valuables and contaminants from industrial and domestic waste discharges. As a whole, ATPS is simple, efficient, rapid, flexible, economical, and biocompatible. Moreover, its selectivity, purity, and yield are up to the standards and sometimes even better than conventional waste discharge treatment technology, making it an ideal extraction and purification technology. Additionally, literature also proved that the superior capabilities of ATPS are fruits of continuous research and development of the system, ultimately transforming it into a versatile mechanism suitable across various industries to purify waste discharges. In light of its elaborate benefits, the study suggests that the system be made compatible with the industrial scale to improve the integration and application process, adding value to the respective waste streams.

[the_background] =>

A well-designed product manufacturing system depends on the efficiency of production and valuable product reclamation, and its downstream waste management strategy. Alas, conventional extraction and purification technologies incur high operational costs, produce lower yield, lack specificity and up-scalability, and use non-eco-friendly components. Alternatively, the aqueous two-phase system (ATPS) has been identified as a better option to overcome the limitations of existing technologies and tools. Therefore, this study aims to review the application of ATPS in diverse industries, emphasizing its capabilities and suggesting ways to improve its industrial-scale implementation.

[the_sdg_impact] =>

According to GAIA, a global network working towards a just and waste-free world without incineration, approximately 2.01 billion tons of waste are generated annually. Unless effective measures are put to work, it is projected that by 2050, the total amount of waste generation will increase by 70% to 3.4 billion tons. Accordingly, Zero Waste initiatives have been adopted in various regions as a sustainable solution to address such waste crisis. Based on the outcome of this review, the aqueous two-phase system (ATPS) could potentially contribute to achieving the targets of the UN’s 12th Sustainable Development Goal, Responsible consumption and production. The adoption of said system across various industries would lead to environmentally sound management of chemicals and wastes throughout the production life cycle while complying with the agreed international framework of Zero Waste.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0048969721013619 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Wastewater-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17528948_1657783805.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.scitotenv.2021.146293 [original_article_reference_fields] => Array ( [publication_title] => Recovery of value-added products from wastewater using Aqueous Two-Phase Systems – A review [journal_title] => Science of The Total Environment [publisher] => Elsevier [year] => July 2021 [subject] => Biotechnology; Wastewater ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [39] => WP_Post Object ( [ID] => 33896 [post_author] => 154 [post_date] => 2022-07-14 15:19:56 [post_date_gmt] => 2022-07-14 07:19:56 [post_content] => [post_title] => Liquid Crystallinity Optimization through Polar Substituents and Chain Length [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => liquid-crystallinity-optimization-through-polar-substituents-and-chain-length [to_ping] => [pinged] => [post_modified] => 2022-07-14 15:19:56 [post_modified_gmt] => 2022-07-14 07:19:56 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33896 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => BHAGAVATH, Poornima [researchers_position] => Department of Chemistry, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Liquid.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0001-5310-1401 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Hydrogen bonding; Induced mesomorphism; Linear HB complexes; Pyridyl units; Smectic phases; Dihalobenzoic acids; Polar substituents [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study demonstrates that when dihalobenzoic acids and pyridyl units (both non-mesogenic) are mixed in an equimolar ratio, a hydrogen-bonded (HB) complex with liquid crystalline behavior (mesomorphism) will be formed. Compared to monohalobenzoic acid HB complexes (with the same pyridyl units), higher liquid crystallinity (mesomorphic thermal stabilities) is observed in dihalobenzoic acid HB complexes. When comparing the effect of different dihalobenzoic acids, 4-chloro-2-fluorobenzoic acid HB complexes exhibit higher liquid crystallinity than 2,4-dichlorobenzoic acid HB complexes. In addition, when a series of pyridyl units with increasing chain length are used, the HB complexes exhibit an increasing liquid crystalline thermal range initially but followed by a downtrend. These results are obtained by studying the samples using various characterization techniques, such as infrared spectroscopy, polarizing optical microscopy, and differential scanning calorimetry.

[the_background] =>

Studies related to liquid crystals (LC) formed through hydrogen bonds have been receiving attention due to their increasing demand in applications like electro-optical and laser devices. The thermal stability of liquid crystals (mesomorphs) relies on various factors, including dipole-dipole interactions, London dispersion forces, dipole-induced dipole interactions, polarity, and polarizability of different molecules. Meanwhile, terminal polar substituents on molecules could significantly change the polarity and polarizability of the system, giving rise to the enhancement or stabilization of mesomorphism. Due to the intriguing phenomena observed in hydrogen-bonded LC systems and the limited number of LC research focusing on mixtures of dihalobenzoic acid and pyridyl units exhibiting, this study aims to examine the effect of hydrogen bond interactions in non-mesomorphic binary systems (using dihalobenzoic acids) on liquid crystalline behavior. These results serve as a valuable complement to the existing knowledge base, specifically in the properties of liquid crystal synthesized using various dihalobenzoic acid and pyridyl units.

[the_sdg_impact] =>

Liquid crystals are a crucial material in applications such as smartphone cameras, device displays, hyperspectral imaging, semiconductors failure analysis, lasers, and pico-projectors. Therefore, an extensive study focusing on understanding and improving liquid crystal properties is necessary to catch up with the emerging applications. The outcomes of this research have successfully enhanced the research on liquid crystals, fulfilling the targets of UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0167732221010370?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Liquid-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17528518_1657782744.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.molliq.2021.116313 [original_article_reference_fields] => Array ( [publication_title] => Influence of polar substituents and flexible chain length on mesomorphism in non-mesogenic linear hydrogen bonded complexes [journal_title] => Journal of Molecular Liquids [publisher] => Elsevier [year] => August 2021 [subject] => Chemistry; Molecular Liquids ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [40] => WP_Post Object ( [ID] => 33882 [post_author] => 154 [post_date] => 2022-07-14 15:05:23 [post_date_gmt] => 2022-07-14 07:05:23 [post_content] => [post_title] => Improvement of the Antenna Isolation by the Bandstop Filter Decoupling Technique [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => improvement-of-the-antenna-isolation-by-the-bandstop-filter-decoupling-technique [to_ping] => [pinged] => [post_modified] => 2022-07-14 15:05:23 [post_modified_gmt] => 2022-07-14 07:05:23 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33882 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ALI, Tanweer [researchers_position] => Department of Electronics and Communication Engineering, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/antenna.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-1959-0480 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Antennas; MIMO communication; PIN photodiodes; Switches; Mutual coupling; Electronic mail; Resonant frequency [graphic_abstract] => [figures] => [video] => [the_novelty] =>

In the study, the proposed miniature reconfigurable multiple-input multiple-output (MIMO) antenna was developed using a switchable bandstop filter as a decoupling structure that can be used for wireless communication systems. The MIMO antenna can enhance channel capacity and reliability as well as integrate multiple communication standards. The antenna was developed through four major steps: creating a single antenna, followed by developing two-port antennas. Then, the reconfigurable decoupling network was developed, which finally led to reconfigurable MIMO antenna development. When the antenna was tested at two different modes, respectively, various parameters were observed, and the measured results of the antenna verified the simulation results. The study results indicated that the antenna efficiency was 86.8% and 91.47% in Mode 1 and Mode 2, respectively. The study indicated that larger reconfigurable MIMO antennas could be developed in the future, potentially consisting of more than two antenna elements through the proposed isolation technique.

[the_background] =>

The MIMO antenna with the proposed bandstop filter reconfiguration can enhance channel capacity and reliability as well as integrate multiple communications standards. This signifies that the bandstop filter reconfiguration proposed in the study succeeds. The goal of the study is to prevent mutual coupling between two closely spaced monopole antenna elements and reconfigure the antenna characteristics. In the study, the MIMO antenna with the proposed bandstop filter reconfiguration showed higher isolation at both operating frequencies than the other antennas reported. The bandstop filter decoupling technique contributed to the improvement in the isolation of the antenna. The study evaluated other antennas and indicated that the antenna proposed in the study has a better dimension than other antennas making it easier to integrate into compact wireless devices.

[the_sdg_impact] =>

Wireless communication systems are increasingly adopted in our everyday life due to flexibility and mobility. Soon, the 5G or fifth generation of cellular networks, one of the fastest wireless technologies to date, would be available globally. The study is strongly associated with “Goal 9: Industry, Innovation and Infrastructure” of the UN’s Sustainable Development Goals (SDG). In the study, the proposed multiple-input multiple-output (MIMO) antenna is regarded as a breakthrough in wireless communication research due to its ability of greater isolation and deeper resonance while integrating multiple communications standards. The antenna’s ability to enhance channel capacity and reliability is better than other antennas of a similar type.

[article_url] => https://ieeexplore.ieee.org/document/9709264 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/antenna-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17528251_1657782093.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1109/ACCESS.2022.3150348 [original_article_reference_fields] => Array ( [publication_title] => Bandstop Filter Decoupling Technique for Miniaturized Reconfigurable MIMO Antenna [journal_title] => IEEE Access [publisher] => IEEE Explore [year] => February 2022 [subject] => Electronics and Communication Engineering; Wireless Communication Systems ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [41] => WP_Post Object ( [ID] => 33868 [post_author] => 154 [post_date] => 2022-07-14 14:36:34 [post_date_gmt] => 2022-07-14 06:36:34 [post_content] => [post_title] => Heart Ultrasound Image as Potential Chronic Kidney Disease Diagnosis Tool [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => heart-ultrasound-image-as-potential-chronic-kidney-disease-diagnosis-tool [to_ping] => [pinged] => [post_modified] => 2022-07-14 14:36:34 [post_modified_gmt] => 2022-07-14 06:36:34 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33868 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GUDIGAR, Anjan [researchers_position] => Department of Instrumentation and Control Engineering, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Heart.png [researchers_profile] => https://www.researchgate.net/profile/Anjan-Gudigar-2 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Chronic kidney disease; FusionGraph embedding; Support vector machine; Ultrasound image [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study developed a novel automated diagnostic system to detect and differentiate different stages of chronic kidney disease (CKD) using ultrasound (US) images of the heart. The proposed computer-aided diagnosis system combined image and feature fusion techniques under a graph embedding framework to characterize heart chamber properties of stage 3 to stage 5 CKD patients. Findings indicated an impressive 100% accuracy in differentiating healthy individuals from CKD patients and a 99.09% accuracy in distinguishing between multiple CKD stages with absolute specificity and sensitivity. Moreover, the utilization of non-invasive heart US imagery as part of a computer-aided diagnosis tool does not only provide a cost-effective approach for CKD staging but also would serve as reliable cardiac health surveillance among CKD patients. Thus, clinicians would be able to monitor the heart conditions of CKD patients effectively and propose early interventions as and when needed.

[the_background] =>

Although the widely available kidney US technique is a relatively low-cost approach to assessing CKD at all stages, it is also time-consuming. It is largely subjected to attending healthcare professionals’ interpretation. Therefore, it is necessary for an automated diagnostic tool to be utilized to improve the reliability of the assessment. Apart from that, CKD patients are known to face a higher risk of developing severe cardiovascular disease. Studies have shown that those with stage 5 CKD undergoing dialysis are 10 to 20 times more prone to the risk of cardiovascular mortality. Hence, continual cardiac assessment of CKD patients, regardless of the disease stage, is necessary to ensure timely intervention and reduce the severity of complications as well as mortality. As a result of such challenges, this study aims to improve the accuracy and sensitivity of CKD screening through automation.

[the_sdg_impact] =>

Globally, over 75 million people are affected by CKD, making it one of the leading public health problems. Studies have also shown that the mortality rate from CKD has increased up to 41.5% from 1990 to 2017. By developing an effective algorithm to screen for CKD progress using heart US imagery, this study improves the prevention rate of premature mortality from non-communicable diseases, mainly cardiovascular diseases. Additionally, the system is generalizable to other medical conditions, hence could potentially serve as a reliable diagnostic tool for the global burden of various other diseases. (SDG 3: Good health and well-being)

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S174680942100330X [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Heart-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17527576_1657780385.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.bspc.2021.102733 [original_article_reference_fields] => Array ( [publication_title] => Automated detection of chronic kidney disease using image fusion and graph embedding techniques with ultrasound images [journal_title] => Biomedical Signal Processing and Control [publisher] => Elsevier [year] => July 2021 [subject] => Instrumentation and Control Engineering; Chronic Kidney Disease ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [42] => WP_Post Object ( [ID] => 33854 [post_author] => 154 [post_date] => 2022-07-14 14:18:52 [post_date_gmt] => 2022-07-14 06:18:52 [post_content] => [post_title] => Effect of Oleic Acid Additives on Performance and NOx Emissions in Biodiesel Engine [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => effect-of-oleic-acid-additives-on-performance-and-nox-emissions-in-biodiesel-engine [to_ping] => [pinged] => [post_modified] => 2022-07-14 14:18:52 [post_modified_gmt] => 2022-07-14 06:18:52 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33854 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => P, Dinesha [researchers_position] => Department of Mechanical and Industrial Engineering, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Oleic.png [researchers_profile] => https://www.researchgate.net/profile/P-Dinesha [researchers_second_profile] => https://orcid.org/0000-0002-2993-4611 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Biodiesel; Hydrogen carrier; NOx; Oleic acid; Optimization; PSO [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study discloses that the emission of oxides of nitrogen (NOx) from a biodiesel engine is minimal when running on Pongamia ester (PE) with 10% oleic acid at a compression ratio (CR) of 17.5 and engine load of 81%. Upon optimization, the NOx is reduced by 72% (100 ppm) at a 2% loss of brake thermal efficiency (BTE) (30.42%). A stationary single-cylinder, four-stroke, water-cooled, variable compression ratio (VCR) compression ignition engine is used in this study. Meanwhile, the optimization of operating conditions involves scientific methods such as the design of experiments (DOE), analysis of variance (ANOVA), regression analysis, and multiobjective particle swarm optimization (MOPSO). In order to fine-tune the current study, future research may use a biodiesel engine with higher flexibility in the variability of engine load as the current engine load can only be controlled at the steps of 25%.

[the_background] =>

Biodiesel is an excellent alternative for conventional combustion-based applications, such as automobiles and power plants. Pongamia oil (PE) (derived from inedible plants) is known as a highly potential source of biodiesel fuel. For better understanding, scientists compared the use of neat PE and PE blends containing diesel fuel. Although PE blends achieved higher brake thermal efficiency (BTE) and combustion duration, there was an increase in NOx emissions. To overcome that, various types of biodiesel additives and their effect have been studied. Despite that, the number of reported studies focusing on the effect of oleic acid additives (e.g., combustion performance, NOx emissions) on biodiesel is still scarce. Furthermore, no optimization study has been carried out to ascertain the optimum oleic acid concentration for the desired reduction in NOx emissions without compromising the combustion performance. Thus, this research strives to investigate the effect of oleic acid additives on the performance and NOx emissions in a PE fuel-operated biodiesel engine. Optimization of the controlling parameters is also conducted to maximize the engine efficiency and minimize NOx emission. The results of this study are valuable for the biotechnology field to provide optimal solutions in improving the efficiency of biofuel while minimizing NOx emissions.

[the_sdg_impact] =>

In the U.S., the burning of fossil fuels accounted for 74% of greenhouse gas emissions in 2019. This alarming scenario implies the urgent need for renewable energy before the environmental damages worsen. Despite the existence of biodiesel which is adequately efficient and less harmful, this study went the extra mile to optimize the performance and properties of biodiesel. Hence, it fulfills UNSDG 7: Affordable & Clean Energy and UNSDG 13: Climate action by increasing the share of renewable energy in the global energy mix.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0360319921019066?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Oleic-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17527230_1657779272.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.ijhydene.2021.05.124 [original_article_reference_fields] => Array ( [publication_title] => NOx reduction of biodiesel engine using pongamia ester with oleic acid and optimization of operating conditions using particle swarm optimization [journal_title] => International Journal of Hydrogen Energy [publisher] => Elsevier [year] => July 2021 [subject] => Mechanical and Industrial Engineering; Biodiesel ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [43] => WP_Post Object ( [ID] => 33840 [post_author] => 154 [post_date] => 2022-07-14 14:06:40 [post_date_gmt] => 2022-07-14 06:06:40 [post_content] => [post_title] => Benefits of Low-Temperature Annealing for Tailoring the Physical Properties of Sn-doped ZnO Thin Film [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => benefits-of-low-temperature-annealing-for-tailoring-the-physical-properties-of-sn-doped-zno-thin-film [to_ping] => [pinged] => [post_modified] => 2022-07-14 14:06:40 [post_modified_gmt] => 2022-07-14 06:06:40 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33840 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KEKUDA, Dhananjaya [researchers_position] => Department Of Physics, Manipal Institute of Technology, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/ZnO.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0003-4041-0138 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Co-sputtering; Tin doped ZnO thin Films; Low temperature air annealing; Photoluminescence; XPS; Hall effect [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study reveals the effect of low-temperature annealing on the properties of tin-doped ZnO [Zn(1-x)Sn(x)O] polycrystalline thin films with a hexagonal wurtzite structure. After being annealed, significant improvement in the electrical parameters is observed. The changes in physical properties include a change in crystal orientation from (002) to (100), an increase in the crystallite sizes (when annealed at 100 °C), an enlargement of optical bandgap from 3.17 to 3.44 eV, an increase in donor-related defects such as oxygen vacancies and Zn interstitials, and an improved blue light emission. Meanwhile, the doping process brings about an increase in oxygen-related defects, a two-order decrement in the resistivity as well as a three-order increment in the carrier concentration. The thin films were grown on glass substrates using DC magnetron reactive co-sputtering techniques. The characterization techniques involved are such as X-ray diffraction (XRD), field emission scanning electron microscope (FESEM), photoluminescence (PL) analysis, X-ray photoelectron spectroscopy (XPS), and van der Pauw resistivity measurement.

[the_background] =>

Zinc oxide (ZnO) is a reputable Transparent Oxide Semiconductors (TOS) for electronic and photonic applications. Its conductivity can be improved tremendously using tin (Sn) dopant, which does not cause any serious lattice distortion. Past studies show that optimized annealing could enhance the overall physical properties of Sn-doped ZnO thin film. Nevertheless, to date, the number of studies focusing on low-temperature annealed Sn-doped ZnO thin film fabricated by DC magnetron reactive co-sputtering remains scanty. Therefore, this study aims to investigate the physical properties of Sn-doped ZnO thin film prepared using the said technique and examine the effect of low-temperature air-annealing. The output of this research expands the knowledge base specifically in the potential application of Sn-doped ZnO thin film as optoelectronic devices (e.g., UV photosensors and thin-film transistors).

[the_sdg_impact] =>

The rapid advancement of technology has led to the designs of high-technology nano-electronic devices to cater to various industrial needs and end-consumer markets. Such phenomena have created a high demand for materials with superior properties. By introducing an effective way to prepare optoelectronic materials with enhanced properties, the outcome of this study is in line with innovative prospects envisioned by UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0921452621007249?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/ZnO-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17527039_1657778594.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.physb.2021.413571 [original_article_reference_fields] => Array ( [publication_title] => An investigation on the role of low temperature annealing on the structural, morphological, optical, and electrical properties of DC magnetron sputtered Zn(1-x)Sn(x)O thin films [journal_title] => Physica B: Condensed Matter [publisher] => Elsevier [year] => March 2022 [subject] => Physics; ZnO ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [44] => WP_Post Object ( [ID] => 33826 [post_author] => 154 [post_date] => 2022-07-14 13:53:03 [post_date_gmt] => 2022-07-14 05:53:03 [post_content] => [post_title] => Study of Coastal Lake Sediments Using a Mineral Magnetic Approach [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => study-of-coastal-lake-sediments-using-a-mineral-magnetic-approach [to_ping] => [pinged] => [post_modified] => 2022-07-14 13:53:03 [post_modified_gmt] => 2022-07-14 05:53:03 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33826 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WARRIER, Anish Kumar [researchers_position] => Department of Civil Engineering and Centre for Climate Studies, Manipal Academy of Higher Education, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/climate.png [researchers_profile] => https://www.researchgate.net/profile/Anish-Warrier [researchers_second_profile] => "https://orcid.org/ 0000-0003-0044-6224" ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Magnetic susceptibility; Magnetic grain size; Weathering; Aeolian; Lake sediments; East Antarctica [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study investigated the abundance, size and type of magnetic minerals present in a 79-cm long sediment core from a land-locked lake (L-49) in Schirmacher Oasis (SO, East Antarctica). The sediment core spans the past 43,000-years. Apart from the abundance of iron oxide minerals traced through the magnetic susceptibility data, biological processes and wind activity were also found to be significant in contributing sediments to the lake across different timescales in the region. Notably, the findings showed that the SO lakes responded well to the changing climate throughout the last glacial period and the Holocene (11700 years BP to the Present). Such reconstruction of the L-49 sediments’ glacial-interglacial climatic and environmental changes would contribute to the expansion of literature and be useful when developing regional and global climate models.

[the_background] =>

Since the East Antarctic Ice Sheet (EAIS) is the largest ice sheet in Antarctica, understanding its response to the changing climate is crucial to prevent or be prepared for potential climate-change-triggered environmental catastrophe. However, there is a grave shortage of data on the past behavior of the EAIS throughout the changing timescales and climate. As linkers of continental ice cores and marine sediments, the study of coastal lake sediments would shed some light on ice sheet dynamics, sea-level changes, isostasy, deglaciation, and ice sheet decay. Therefore, this study uses the properties of magnetic minerals to reconstruct glacial-interglacial climatic and environmental changes from sediments of a land-locked lake.

[the_sdg_impact] =>

According to the data presented by Climate.gov, the global sea level has risen to a new record high in 2020, 91.3 mm (3.6 inches) above 1993 levels. Consequently, more high-tide flooding and other environmental catastrophe are to be expected, leaving behind massive damage to the infrastructure and disrupting the livelihood of many. By providing up-to-date and comprehensive data on the glacial conditions of the largest ice sheet and its role in the rising sea levels, the findings of this study allow scientists, environmentalists, and world leaders to devise urgent and strategic action to combat climate change and minimize its damages. (SDG 13: Climate action)

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0341816221001594 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/climate-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17526816_1657777584.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.catena.2021.105300 [original_article_reference_fields] => Array ( [publication_title] => A 43-ka mineral magnetic record of environmental variations from lacustrine sediments of Schirmacher Oasis, East Antarctica [journal_title] => CATENA [publisher] => Elsevier [year] => July 2021 [subject] => Civil Engineering; Climate Studies ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [45] => WP_Post Object ( [ID] => 33810 [post_author] => 154 [post_date] => 2022-07-14 13:29:57 [post_date_gmt] => 2022-07-14 05:29:57 [post_content] => [post_title] => Novel Raman Spectroscopy Approach for Competent Cell Membrane Studies [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => novel-raman-spectroscopy-approach-for-competent-cell-membrane-studies [to_ping] => [pinged] => [post_modified] => 2022-07-14 13:29:57 [post_modified_gmt] => 2022-07-14 05:29:57 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33810 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => BANKAPUR, Aseefhali [researchers_position] => Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Raman.png [researchers_profile] => https://www.researchgate.net/profile/Dr-Aseefhali-Bankapur [researchers_second_profile] => https://orcid.org/0000-0001-9237-8980 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Molecules; Monomers; Peptides and proteins; Plasma membrane; Raman spectroscopy [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Using an optical vortex beam, this study proposed a novel method for optically immobilizing the red blood cells (RBCs) in a favorable orientation, improving Raman analysis sensitivity in cell membrane studies for higher cell volume. An extensive spectral analysis using the optical vortex beam was compared with the conventional Gaussian beam-based measurements to validate both efficiency and sensitivity of the method proposed. As a result, the optical trapping of RBC in a face-on orientation enabled physiological and biochemical properties of hemoglobin (Hb) molecules near RBC membrane as well as inside the bulk of the cell to be distinguished precisely. Such evidence is crucial to unravel the elaborate potentials of Raman spectroscopy in cellular studies and disease development.

[the_background] =>

Understanding the role of cell membranes in cellular homeostasis is vital to prevent the development of several non-communicable diseases. The conventional optical immobilization of single functional cell using Gaussian beam limits Raman spectroscopy's potential in efficiently analyzing cell membrane. Such is primarily due to the restrictions in cell orientation with regards to the beam direction and cell volume. Therefore, the study aims to provide a feasible replacement of the beam used in Raman spectroscopy to improve cell membrane analysis and understanding.

[the_sdg_impact] =>

Over the years, the usefulness of Raman spectroscopy as a non-invasive diagnostic tool for a range of diseases has been well established, not without its limitations. The new method proposed in this study, which utilizes an optical vortex beam instead of a Gaussian beam, enhances the performance of Raman spectroscopy in terms of cell membrane analysis. Based on the outcomes, it is apparent that such innovation could broadly impact the future development of medicines for communicable and non-communicable diseases as envisioned in the 3rd United Nations' Sustainable Development Goal, Good health and well-being.

[article_url] => https://pubs.acs.org/doi/10.1021/acs.analchem.0c05204 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/raman2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17526530_1657776185.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1021/acs.analchem.0c05204 [original_article_reference_fields] => Array ( [publication_title] => Optical Trapping and Micro-Raman Spectroscopy of Functional Red Blood Cells Using Vortex Beam for Cell Membrane Studies [journal_title] => Analytical Chemistry [publisher] => ACS Publication [year] => March 2021 [subject] => Molecular Physics; Chemistry ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [46] => WP_Post Object ( [ID] => 33793 [post_author] => 154 [post_date] => 2022-07-14 12:29:07 [post_date_gmt] => 2022-07-14 04:29:07 [post_content] => [post_title] => Impact of Investor-Agent Relationship in Choosing Life Insurance Policy [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => impact-of-investor-agent-relationship-in-choosing-life-insurance-policy [to_ping] => [pinged] => [post_modified] => 2022-07-14 12:30:50 [post_modified_gmt] => 2022-07-14 04:30:50 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33793 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SHETTY, Ankitha [researchers_position] => Department of Commerce, Manipal Academy of Higher Education, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/akitha.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-1314-7322 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Decision making; Insurance; Trust; Investors; Agent; Relational selling [graphic_abstract] => [figures] => [video] => [the_novelty] =>

To better understand investors’ buying decisions in life insurance, this study discloses how the investor-agent relationship affects the decision-making process. Trust is among the most influential prerequisites as it fully mediates the effect of agent disclosure and personal rapport on decision-making. Besides that, interaction intensity with agents, co-operative intentions of agents, and sharing of overt and covert information also significantly impact the decision-making process. These insights are derived from a questionnaire answered by 813 policyholders of life insurance companies operating in South India. A partial least square method of structural equation modeling is applied to analyze the data. Future research can expand the study scope of relational selling by focusing on adaptive and team selling behavior and diving into health insurance, auto insurance, and property insurance.

[the_background] =>

The chances of closing deals in the insurance industry depend mainly on the potential investors’ confidence and trust in the insurance agents responsible for providing valuable and accurate policy information. Although the ethical conduct of agents is known to be a primary determining factor, the effect of investor‒agent relationships on the decision-making process of acquiring insurance policy remains unclear. Hence, this study investigates the impact of relational selling behavior on insurance decision-making and explores the significance of trust in making such decisions. The outcome would provide valuable inputs to insurance companies by highlighting the key relational prerequisites to be emphasized while establishing and maintaining a fruitful long-term relationship with investors.

[the_sdg_impact] =>

The development of the insurance sector is crucial to the general economic growth of the nation by generating long-term financial resources and employment. Thus, the profitability of the insurance sector ought to be a main national financial agenda. This study has successfully identified the effect of relational selling on life insurance decision-making in India. As the ultimate focus is directed toward promoting sustainable economic growth, the study is well-aligned with UNSDG 8: Decent Work & Economic Growth.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/IJBM-09-2018-0236/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Relational-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17525702_1657772739.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/IJBM-09-2018-0236 [original_article_reference_fields] => Array ( [publication_title] => The effect of relational selling on life insurance decision making in India [journal_title] => International Journal of Bank Marketing [publisher] => Emerald Publishing [year] => June 2019 [subject] => Social Science; Insurance ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [47] => WP_Post Object ( [ID] => 33778 [post_author] => 154 [post_date] => 2022-07-14 12:20:39 [post_date_gmt] => 2022-07-14 04:20:39 [post_content] => [post_title] => Life Insurance Industry: Efficiency of Traditional & Corporate Agents [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => life-insurance-industry-efficiency-of-traditional-corporate-agents [to_ping] => [pinged] => [post_modified] => 2022-07-14 12:31:28 [post_modified_gmt] => 2022-07-14 04:31:28 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33778 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SHETTY, Ankitha [researchers_position] => Department of Commerce, Manipal Academy of Higher Education, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/akitha.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-1314-7322 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Bancassurance; traditional agents; insurance companies; cost efficiency; data envelopment analysis [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Upon assessing the technical efficiency of traditional and corporate agents in the Indian life insurance industry, this study concludes that there is no significant difference between the efficiency scores of traditional and corporate agents. These findings also indicate that efficiency scores and market share are not necessarily negatively correlated, opposing the Quiet life hypothesis. The research is conducted by examining the sales efficiency of 12 traditional and corporate agency channels between 2012 and 2016 using the non-parametric approach of data envelopment analysis (DEA). By minimizing the non-availability of data and increasing the sample size, a more accurate and comprehensive outcome can be expected in future studies.

[the_background] =>

The profitability of the life insurance industry in India relies strongly on the efficiency of the distribution channels, such as traditional and corporate agencies. However, these agencies are bound to face difficulties like high turnover rate, increasing expenses, and unsatisfying sales figures. Thus, to confront these issues, this study is carried out to focus on the efficiency of insurance distribution channels. Based on the proven low efficiency of both the traditional and corporate media, this study suggests that insurance companies should reduce the number of agents and commission expenses. The output of this research serves as a solid reference for future strategizing and efficiency improvement of distribution channels, including leveraging digital insurance as an alternative distribution channel.

[the_sdg_impact] =>

The insurance industry is essential for the stability of financial systems because they are part of the prominent investors in financial markets and because the insurers safeguard the financial stability of households and firms by insuring their risks. Therefore, the sustainability and profitability of the insurance industry are critical to the economic growth of a country. By attempting to strengthen the capacity and improve the efficiency of the insurance industry, this study aligns with the targets of UNSDG 8: Decent Work & Economic Growth.

[article_url] => https://journals.sagepub.com/doi/10.1177/0972150917749722 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Insurance-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/07/17525542_1657772117.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1177/0972150917749722 [original_article_reference_fields] => Array ( [publication_title] => Assessing the Technical Efficiency of Traditional and Corporate Agents in Indian Life Insurance Industry: Slack-based Data Envelopment Analysis Approach [journal_title] => Global Business Review [publisher] => Sage Publishing [year] => January 2018 [subject] => Social Science; Insurance ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [48] => WP_Post Object ( [ID] => 33629 [post_author] => 154 [post_date] => 2022-06-29 18:07:35 [post_date_gmt] => 2022-06-29 10:07:35 [post_content] => [post_title] => Highly-Effective Nanozymes for Biomedicine and Industrial Catalysis [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => highly-effective-nanozymes-for-biomedicine-and-industrial-catalysis [to_ping] => [pinged] => [post_modified] => 2024-02-19 13:33:16 [post_modified_gmt] => 2024-02-19 05:33:16 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33629 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YAN, Xiyun (阎锡蕴) [researchers_position] => CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/06/Nanozymes-2.png [researchers_profile] => https://www.researchgate.net/profile/Xiyun-Yan [researchers_second_profile] => https://orcid.org/0000-0002-7290-352X ) [researchers_info_2] => Array ( [researchers_name_2] => FAN, Kelong (范克龙) [researchers_position_2] => CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/06/Kelong-Fan.jpg [researchers_profile_2] => https://www.researchgate.net/profile/Kelong-Fan [researchers_second_profile_2] => https://orcid.org/0000-0001-6285-1933 ) [original_article_reference] => [research_footprints] => Biotechnology; Chemical structure; Metals; Monomers; Peptides and proteins [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/06/AMR_Article_04_v1_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

By learning form natural enzymes, artificial enzymes (i.e. nanozymes) synthesized using nanomaterials have high potential in achieving or even surpassing the catalytic effectiveness of natural enzymes. Based on the role of amino acids in the active sites of natural enzymes, a desirable catalytic microenvironment can be prepared for nanozymes via simulations. Besides, nanozymes could possess adjustable enzyme-like activities by having coordination structures which are developed according to natural enzymes’ chemical coordination principles. To realize a more ideal nanozyme, future studies could focus on improving the specificity of catalysis as well as the flexibility and variability of active sites.

[the_background] =>

Nanozymes are artificial enzymes prepared using nanomaterials. They exhibit outstanding properties such as high stability, adjustable catalytic activities, wide range of functionality, high recyclability, and highly feasible for large-scale production. Although there has been significant progress, further optimizations are necessary so as to put nanozymes into applications. With the hope to inspire and to gain more attention from researchers, this study discusses the omnidirectional simulation of natural enzymes from an amino acid microenvironment to metal-free architecture, and to a metal coordination structure. The research output boosts the materialization of highly effective and highly efficient nanozymes which will bring biomedicine and industrial catalysis to a whole new level.

[the_sdg_impact] =>

Despite the rapid advances of medical science, an effective cure is still in need to treat inherited metabolic disorders which result in a number of life-changing or life-threatening conditions. The achievement of this study paves a clear path and direction as well as creates a realistic hope for the future development of nanozymes research (UNSDG 9: Industry, Innovation & Infrastructure). By being proactive in optimizing the development of nanozymes, patients of inherited metabolic disorders would stand higher chance to recover and live like any other individuals (UNSDG 3: Good Health & Well-Being).

[article_url] => https://pubs.acs.org/doi/abs/10.1021/accountsmr.1c00074 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/06/Nanozymes-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/06/17147652_1656496597.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1021/accountsmr.1c00074 [original_article_reference_fields] => Array ( [publication_title] => Nanozymes Inspired by Natural Enzymes [journal_title] => Accounts of Materials Research [publisher] => ACS Publication [year] => June 2021 [subject] => Material Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/YKkGs6WhH7E [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/06/AMR04v5.mp4_snapshot_00.01_2022.10.26_09.51.57.jpg ) ) [49] => WP_Post Object ( [ID] => 33605 [post_author] => 154 [post_date] => 2022-06-29 17:44:02 [post_date_gmt] => 2022-06-29 09:44:02 [post_content] => [post_title] => Dip-Coating for Fabrication of Microstructured Ultrathin Organic Semiconductor Film [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => dip-coating-for-fabrication-of-microstructured-ultrathin-organic-semiconductor-film [to_ping] => [pinged] => [post_modified] => 2024-02-19 13:31:04 [post_modified_gmt] => 2024-02-19 05:31:04 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33605 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LI, Li-qiang (李立强) [researchers_position] => Department of Chemistry, Tianjin University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/09/Ultrathin-.jpg [researchers_profile] => https://www.researchgate.net/profile/Liqiang-Li-3 [researchers_second_profile] => https://orcid.org/0000-0001-8399-3957 ) [researchers_info_2] => Array ( [researchers_name_2] => CHI, Li-feng (迟力峰) [researchers_position_2] => The Functional Nano & Soft Materials Laboratory, Soochow University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/09/Ultrathin-4.jpg [researchers_profile_2] => https://www.researchgate.net/profile/Lifeng-Chi [researchers_second_profile_2] => https://orcid.org/0000-0003-3835-2776 ) [original_article_reference] => [research_footprints] => Microstructures; Molecular structure; Molecules; Monolayers; Optoelectronics; Solution chemistry; Solvents [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/09/AMR_Article_03_v3_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

With the aim to realize state-of-the-art organic semiconductor (OSCs) via dip-coating, this study has comprehensively discussed the assembly strategy, underlying mechanism, critical factors, and applications of microstructured ultrathin organic semiconductor films (MUOSFs). The critical factors are such as pulling speed, molecular structures, and solution properties. The fundamental rule in preparing MUOSFs with different kinds of molecules (for different purposes) is to focus on the nucleation rate, assembly rate, and recession rate. Such rule will bring balance between the critical factors and, in turn, leads to fabrication of one-dimensional microstripes and two-dimensional films. By applying in-depth knowledge of dip-coating, this study has successfully prepared uniform, continuous, highly ordered, and large-area MUOSFs with monolayer precision. The expansion plan of this research includes dip-coating MUOSFs with face-on molecular orientations, growing continuous 2D molecular crystals over a large area, producing multiple component systems (e.g. cocrystals and heterojunctions), optimizing the overall morphology, and fabricating MUOSFs on wafers.

[the_background] =>

The potential of organic electronics is proven by the successful commercialization of active-matrix organic light-emitting diodes (OLEDs) for high-end smartphone displays. This milestone has gained OSCs tremendous attention which gave rise to the ambition of further enhancing the properties and performance of OSCs. As ultrathin OSC microstructures comprise one to several molecular layers (i.e. microstructured ultrathin organic semiconductor films (MUOSFs)), a highly controlled assembly method is in high demand to improve and design the OSCs’ properties for different applications. Aiming at the molecular-level precision of dip-coating technique, this study emphasizes on the assembly strategy, the underlying mechanism, and potential applications of MUOSFs. The output of this study plays a significant role in facilitating future research on optimizing the properties and performance MUOSFs.

[the_sdg_impact] =>

OSCs have promising prospects for use in various electrical and optoelectric devices such as solar cells, transistors, photodetectors, and lasers. With the advantages of being eco-friendly, lower-cost and flexible, the advances of OSCs will be a game-changer for the development of electronic devices. This study supports and enhances the research related to OSCs and, hence, it fulfils UNSDG 9: Industry, Innovation, and Infrastructure.

[article_url] => https://pubs.acs.org/doi/10.1021/accountsmr.0c00042 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/06/Semiconductor-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/09/19275544_1663654264.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1021/accountsmr.0c00042 [original_article_reference_fields] => Array ( [publication_title] => Microstructured Ultrathin Organic Semiconductor Film via Dip-Coating: Precise Assembly and Diverse Applications [journal_title] => Accounts of Materials Research [publisher] => ACS Publication [year] => November 2020 [subject] => Material Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/OdoooQ8dyuE [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/06/AMR02v9.mp4_snapshot_00.01_2022.10.24_17.51.33.jpg ) ) [50] => WP_Post Object ( [ID] => 33581 [post_author] => 154 [post_date] => 2022-06-29 17:25:41 [post_date_gmt] => 2022-06-29 09:25:41 [post_content] => [post_title] => Structural Design and Recent Advances of Eu2+-doped Silicates Phosphors for LED Applications [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => structural-design-and-recent-advances-of-eu2-doped-silicates-phosphors-for-led-applications [to_ping] => [pinged] => [post_modified] => 2024-02-19 13:29:00 [post_modified_gmt] => 2024-02-19 05:29:00 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33581 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => XIA, Zhiguo (夏志国) [researchers_position] => State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/06/夏志国.jpg [researchers_profile] => https://www.researchgate.net/profile/Xia-Zhiguo [researchers_second_profile] => https://orcid.org/0000-0002-9670-3223 ) [researchers_info_2] => Array ( [researchers_name_2] => ZHAO, Ming (赵鸣) [researchers_position_2] => Faculty of Science, Beijing University of Technology, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/06/Phosphors.jpg [researchers_profile_2] => https://www.researchgate.net/profile/Ming-Zhao-103 [researchers_second_profile_2] => https://orcid.org/0000-0002-8321-7875 ) [original_article_reference] => [research_footprints] => Color; Crystal structure; Crystals; Luminescence; Phosphors; LED [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/06/AMR_Article_02_v2_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

This study has revealed the crucial structural engineering to effectively develop Eu2+-doped silicates phosphors for LED applications. The distinctive luminescence properties of Eu2+ are attributed to the centroid shift of the 5d levels subshell, the energy difference between the lowest and highest 5d levels (crystal field splitting), the energy difference between the maximum of the lowest excitation band and that of the emission band (stoke shift), as well as the broad emission bandwidth. Therefore, the Eu2+ emission in silicates can possibly be tuned via various structural strategies, such as substitutions (to modify the chemical composition and crystal structure), identifying an optimal crystallographic site for Eu2+, and controlling crystalline phase transition. The results are diverse when different crystal structures and/or local structures are involved. The progress of recent research focusing on daily applications has been outlined comprehensively. These applications include white LED lighting, liquid-crystal displays (LCD) LED backlights, and near-infrared LEDs for medical and night-vision use. In order to keep advancing of Eu2+-doped silicates phosphors for emerging LED applications, future studies can focus on the deeper understanding on the relationship of structural rigidity and Eu2+ luminescence, as well as the discovery of new phosphor sytems.

[the_background] =>

Although phosphor-converted light-emitting diodes (pc-LEDs) have been commonly used, there is still room for improvement for its performance which mainly relies on the luminescence properties of phosphors used. Meanwhile, besides being low cost, Eu2+-doped earth abundant silicates phosphors are excellent luminescent materials for optoelectronic applications. With tunable bandwidth, their emission colors can cover near-ultraviolet (n-UV) to near-infrared (NIR). Due to its high potential, scientists are aspired to push the limits of Eu2+-doped silicate phosphors in materializing the state-of-the-art LED applications. This study contributes by shedding light on the significant structure−property relationships and the Eu2+ photoluminescence mechanism. Such effort would facilitate researchers in developing higher-performance Eu2+-doped phosphors to cater emerging applications.

[the_sdg_impact] =>

The global LED lighting market reached a value of US$ 84 Billion in 2020. The high global market demand indicates the importance of LED for diverse applications (both industrial- and consumer-use). By focusing on pushing the limits of LED using Eu2+-doped silicates phosphors, this study shows good alignment with UNSDG9: Industry, Innovation & Infrastructure. Cutting-edge LEDs will directly enhance the features and performance of countless devices and equipment.

[article_url] => https://pubs.acs.org/doi/10.1021/accountsmr.0c00014 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/06/Phosphors4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/06/17146773_1656494246.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1021/accountsmr.0c00014 [original_article_reference_fields] => Array ( [publication_title] => Structural Engineering of Eu2+-Doped Silicates Phosphors for LED Applications [journal_title] => Accounts of Materials Research [publisher] => ACS Publication [year] => October 2020 [subject] => Material Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/-oD9tYXTrmo [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/06/AMR-03-w-subs-music.mp4_snapshot_00.01_2022.10.26_09.55.58.jpg ) ) [51] => WP_Post Object ( [ID] => 33525 [post_author] => 154 [post_date] => 2022-06-15 09:42:58 [post_date_gmt] => 2022-06-15 01:42:58 [post_content] => [post_title] => Opportunistic Lung Cancer Screening: Good or Bad? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => opportunistic-lung-cancer-screening-good-or-bad [to_ping] => [pinged] => [post_modified] => 2022-06-15 09:44:05 [post_modified_gmt] => 2022-06-15 01:44:05 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33525 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GAO, Wayne (高志文) [researchers_position] => Global Health Security Research Center, Taipei Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/06/tomography-.png [researchers_profile] => https://www.researchgate.net/profile/Wayne-Gao-3 [researchers_second_profile] => https://orcid.org/0000-0002-6083-5849 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Overdiagnosis; Observational study; Lung cancer screening; Randomized trial; Cohort study [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2022/06/img-004.png [video] => [the_novelty] =>

This study highlights the adverse effects of opportunistic lung cancer screening promotion from the non-smoking Taiwanese women population perspective. Findings indicate that the rise of low dose computed tomography (LDCT) screening among low-risk women population led to 6 times higher early-stage lung cancer detection from 2004 to 2018 with no change in the incidence of late-stage lung cancer. Even with a consistent lung cancer mortality, the 5-year survival rate has more than doubled within the given period. This concludes the potential misleading feedback that follows unnecessary excessive cancer screening. Without dismissing the benefits of LDCT screening for lung cancer, the study suggests the target groups be heavy-smoker specific for better reliability instead of broad low-risk population screening.

[the_background] =>

Over the years, lung cancer screening criteria have expanded, and opportunistic screening for the disease has been actively promoted among lower-risk groups. Increased incidence of lung cancer has been reported even as the smoking population and other risk factors continue to decrease. Considering these observations, researchers find that it is crucial to understand the association of lung cancer incidence with the promotion of screening in a predominantly non-smoking population. Potentially, the findings would highlight the health and economic impacts as well as reliability of opportunistic screening among lower-risk groups, serving as an important reference for healthcare policymakers.

[the_sdg_impact] =>

According to WHO, in 2020 alone, out of 2.21 million lung cancer cases reported, there were approximately 1.80 million deaths. Apart from prevention efforts, early detection is believed to play a prominent role in reducing cancer mortality. Consequently, opportunistic screening has been heavily promoted, not just among heavy smokers, but also among those from the lower-risk population. However, this study’s findings elaborated on the adverse effects of such excessive screening and the economic impact on national insurance coverage as a result of overdiagnosis and downstream medical procedure expenses. Accordingly, healthcare policymakers could refer to these findings for a better decision-making process concerning health coverage, and quality and affordability of medical services. (UN SDG 3: Good health and well-being)

[article_url] => https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2788296 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/06/tomography-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/06/16763502_1655256825.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1001/jamainternmed.2021.7769 [original_article_reference_fields] => Array ( [publication_title] => Association of Computed Tomographic Screening Promotion With Lung Cancer Overdiagnosis Among Asian Women [journal_title] => JAMA Internal Medicine [publisher] => JAMA Network [year] => January 2022 [subject] => Medical; Lung Cancer; Social Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [52] => WP_Post Object ( [ID] => 33459 [post_author] => 154 [post_date] => 2022-06-07 22:57:47 [post_date_gmt] => 2022-06-07 14:57:47 [post_content] => [post_title] => Low-background Neutron Detector for Precise Measurement of Reaction Cross-Section [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => low-background-neutron-detector-for-precise-measurement-of-reaction-cross-section [to_ping] => [pinged] => [post_modified] => 2023-12-26 10:15:19 [post_modified_gmt] => 2023-12-26 02:15:19 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33459 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LI, Yutian (李宇田) [researchers_position] => CAS Key Laboratory of High Precision Nuclear Spectroscopy, Institute of Modern Physics, Chinese Academy of Sciences, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/06/Neutron.png [researchers_profile] => https://www.researchgate.net/profile/Yutian-Li-7 [researchers_second_profile] => https://orcid.org/0000-0001-5638-6406 ) [researchers_info_2] => Array ( [researchers_name_2] => GAO, Bingshui Gao [researchers_position_2] => CAS Key Laboratory of High Precision Nuclear Spectroscopy, Institute of Modern Physics, Chinese Academy of Sciences, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/06/Neutron-2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-7911-3950 ) [original_article_reference] => [research_footprints] => Underground laboratory; Neutron detector; Low background; 3He Counter [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/06/2022_NST_Article_04_v1_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

This study has successfully developed a high-efficiency neutron detector array with an exceptionally low background to measure the cross-section of the 13C(α,n)16O reaction at the China Jinping Underground Laboratory (CJPL). Comprising 24 3He proportional counters embedded in a polyethylene moderator, and shielded with 7% borated polyethylene layer, the neutron background at CJPL was as low as 4.5 counts/h, whereby 1.94 counts/h was attributed to the internal α radioactivity. Remarkably, the angular distribution of the 13C(α,n)16O reaction was proven to be a primary variable affecting the detection efficiency. The detection efficiency of the array for neutrons in the range of 0.1MeV to 4.5 MeV was determined using the 51V(p, n)51Cr reaction carried out with the 3 MV tandem accelerator at Sichuan University and Monte Carlo simulations. Future studies can be planned to focus on further improvement of the efficiency accuracy by measuring the angular distribution of 13C(α,n)16O reaction.

[the_background] =>

Gamow window is the range of energies which defines the optimal energy for reactions at a given temperature in stars. The nuclear cross-section of a nucleus is used to describe the probability that a nuclear reaction will occur. The 13C(α,n)16O reaction is the main neutron source for the slow neutron capture process (s-process) in asymptotic giant branch (AGB) stars, in which the 13C(α,n)16O reaction occurs at the Gamow window spanning from 150 to 230 keV. Hence, it is necessary to precisely measure the cross-section of 13C(α,n)16O reaction in this energy range. A low-background and high detection efficiency neutron detector is the essential equipment to carry out such measurements. This study developed a low-background neutron detector array that exhibited high detection efficiency to address the demands. With such development, advanced studies, including direct cross-section measurements of the key neutron source reactions in stars, can be conducted in the near future.

[the_sdg_impact] =>

Low-background neutron detectors play a crucial role in facilitating research related to nuclear astrophysics, neutrino physics, and dark matter. By improving the efficiency and upgrading the technological capability of low background neutron detectors, this study indirectly contributes to the enhancement of scientific research. Additionally, fields involving material science and nuclear reactor technology would also benefit from the perfection of neutron detector technology. Taking into consideration the potential application and expansion of these findings, such innovative attempt aligns well with UNSDG9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-022-01030-0 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/06/Neutron-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/06/16556096_1654613470.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-01030-0 [original_article_reference_fields] => Array ( [publication_title] => Development of a low-background neutron detector array [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => April 2022 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [53] => WP_Post Object ( [ID] => 33404 [post_author] => 154 [post_date] => 2022-06-07 11:02:09 [post_date_gmt] => 2022-06-07 03:02:09 [post_content] => [post_title] => Hadronic Interactions and Collective Flow in High-Baryon-Density Region [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => hadronic-interactions-and-collective-flow-in-high-baryon-density-region [to_ping] => [pinged] => [post_modified] => 2023-12-26 10:13:01 [post_modified_gmt] => 2023-12-26 02:13:01 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33404 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LAN, Shaowei [researchers_position] => College of Physical Science and Technology, Central China Normal University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/06/Hadronic.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => SHI, Shusu [researchers_position_2] => College of Physical Science and Technology, Central China Normal University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/06/Hadronic-2.png [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Heavy-ion collisions; QCD phase diagram; UrQMD; Collective flow; Mean-field potential [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/06/2022_NST_Article_03_v2_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

This study showed the significance of hadronic interactions in developing collective flow in the high-baryon-density region. The statement was derived from the finding whereby a mean-field mode with strong repulsive interaction is needed to reproduce the recent STAR results of 10–40% centrality at √sNN = 3 GeV. Besides that, the energy dependence of directed and elliptic flows was discussed comprehensively. The research was conducted based on Monte Carlo event samples of Au+Au collisions at center of mass energies of √ sNN = 2.11 – 4.9 GeV generated by version 3.4 of the UrQMD model (including both cascade and mean-field modes). These findings contribute to a richer knowledge base in particle physics.

[the_background] =>

High-energy (relativistic) heavy-ion collisions produce an enormous amount of subatomic particles in all directions. In such collisions, the term “flow” describes how energy, momentum, and number of these particles vary with direction. Collective flow describes a movement of a large number of subatomic particles either in a common direction or at a common magnitude of velocities. Meanwhile, elliptic flow measures how the flow is not uniform in all directions when viewed along the beamline. Besides proving the existence of quark-gluon plasma, elliptic flow is one of the most important observations measured at the Relativistic Heavy Ion Collider (RHIC). A recent study conducted by Solenoidal Tracker at RHIC (STAR) implied that the hadronic interactions dominated the equation of state in collisions at center of mass energies of √ sNN = 3 GeV (a region with a high baryon density baryon chemical potential of 750 MeV). As an effort to explore phase structure in the high baryon density region, this research deployed a hadronic transport model, known as the ultra-relativistic quantum molecular dynamics model (UrQMD), to study the directed and elliptic flows in the high baryon density region by using Monte Carlo event samples of Au+Au collisions. Other than marking a new milestone for the second phase of the beam energy scan at the RHIC (BES-II) program, the outcome paves the path to understanding experimental data from upcoming experimental facilities focused on the high baryon density region.

[the_sdg_impact] =>

A better understanding of the properties of the high baryon density region is essential in facilitating future research related to particle physics. This is crucial as the advancement of particle physics will directly impact the expansion of nuclear physics and other closely connected fields. In extension, such enhancement of advanced physics research contributes to the realization of 9th UNSDG: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-022-01006-0 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/06/Hadronic-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/06/16537826_1654570579.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-01006-0 [original_article_reference_fields] => Array ( [publication_title] => Anisotropic flow in high baryon density region [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => February 2022 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/H-Bec97D2Ww [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/06/NST22-03-with-Chinese-Sub.mp4_snapshot_00.01_2022.06.07_11.05.06.jpg ) ) [54] => WP_Post Object ( [ID] => 33322 [post_author] => 154 [post_date] => 2022-05-23 12:42:56 [post_date_gmt] => 2022-05-23 04:42:56 [post_content] => [post_title] => Improving Energy Production from the Digestion Process of Palm Oil Mill Effluent (POME) [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => improving-energy-production-from-the-digestion-process-of-palm-oil-mill-effluent-pome [to_ping] => [pinged] => [post_modified] => 2022-05-23 12:42:56 [post_modified_gmt] => 2022-05-23 04:42:56 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33322 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WONG, Lai Peng [researchers_position] => Department of Environmental Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Palm.png [researchers_profile] => https://www.researchgate.net/profile/Lai-Wong [researchers_second_profile] => https://orcid.org/0000-0002-9172-5183 ) [researchers_info_2] => Array ( [researchers_name_2] => MOHAMED, Hasnain Isa [researchers_position_2] => Civil Engineering Programme, Faculty of Engineering, Universiti Teknologi Brunei, Brunei [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Palm-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Mohamed-Hasnain-Isa [researchers_second_profile_2] => https://orcid.org/0000-0002-6254-5693 ) [original_article_reference] => [research_footprints] => Anaerobic digestion; Biogas; Palm oil mill effluent; Mesophilic temperature; Ultrasound [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S0048969720313450-ga1_lrg.jpg [figures] => [video] => [the_novelty] =>

The novelty of this research is observed in its contribution in enhancing the energy (biogas) production in the standard waste treatment of POME, highly polluted wastewater, through the ultrasonication pre-treatment. The standard waste treatment of POME involves the anaerobic digestion process that produces energy (biogas) as its main outcome. By incorporating the proposed pre-treatment method, the researchers found that POME particle size reduced while its organic surface matter increased for microbial degradation. Additionally, the metabolic activity of anaerobes involved in the digestion process is also reported to increase. These findings conclude that the ultrasonication pre-treatment is promisingly effective as it enhances anaerobic digestion and increases biogas production rates at 30 oC to 35oC. Therefore, this research not only enhances energy production from waste materials but also improves the standard waste treatment method, facilitating multiple stakeholders in strategizing the promotion and practice of generating energy from waste more effectively in the future.

[the_background] =>

To reduce dependence on fossil fuels, renewable energy sources are effective alternatives in overcoming this issue. While there are various forms of renewable energy, an upcoming clean and promising renewable energy is biogas obtained from the anaerobic digestion process. This same process is used to treat POME, making POME a high potential renewable energy source in Malaysia since it is one of the country’s primary commodities. The standard treatment of POME is also lower when compared to other alternatives, prompting a large amount of work focusing on the use of POME as a cheap source for biogas production. However, limited attention has been paid to enhancing the biogas production process itself, motivating the researchers to fill this gap by investigating the use of ultrasound as pre-treatment and identifying the optimum temperature range – an important parameter in the digestion process.

[the_sdg_impact] =>

The economy of a region is largely dependent on its energy reservoir, where fossil fuels remain the main source of energy. However, Shell International predicts that by 2050, 30% of global primary energy consumption will consist of renewable energy. Thus, the use of renewable energy is a future imperative, requiring relevant parties to ensure the production efficiency of these resources. In improving the conversion process of waste to energy, this research proposes a valuable, sustainable strategy, closely aligning with UNSDG 7: Affordable and Clean Energy. Centering on POME, a source of modern energy, this research further enables clean and efficient energy usage.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0048969720313450?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Palm-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16128186_1653280733.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.scitotenv.2020.137833 [original_article_reference_fields] => Array ( [publication_title] => Improved anaerobic digestion of palm oil mill effluent and biogas production by ultrasonication pretreatment [journal_title] => Science of The Total Environment [publisher] => Elsevier [year] => June 2020 [subject] => Environmental Engineering; Biogas ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [55] => WP_Post Object ( [ID] => 33299 [post_author] => 154 [post_date] => 2022-05-23 12:31:49 [post_date_gmt] => 2022-05-23 04:31:49 [post_content] => [post_title] => Improving the Generation of Solar Power through the Optimisation of Solar Farm Layout [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => improving-the-generation-of-solar-power-through-the-optimisation-of-solar-farm-layout [to_ping] => [pinged] => [post_modified] => 2022-05-23 12:31:49 [post_modified_gmt] => 2022-05-23 04:31:49 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33299 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TAN, Ming Hui [researchers_position] => Department of Environmental Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Power.png [researchers_profile] => https://www.researchgate.net/profile/M-Tan-2 [researchers_second_profile] => https://orcid.org/0000-0002-3303-6304 ) [researchers_info_2] => Array ( [researchers_name_2] => CHONG, Kok Keong [researchers_position_2] => Department of Electrical and Electronic Engineering, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Power-2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-7350-597X ) [original_article_reference] => [research_footprints] => concentrator photovoltaic (CPV) system; solar power; computational algorithm; solar power plants; electricity [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S0038092X20305181-ga1_lrg.jpg [figures] => [video] => [the_novelty] =>

When it comes to solar power, the conventional generating system has evolved to include an increasingly popular alternative, the concentrator photovoltaic (CPV) system, as it is highly efficient in converting power (46%). CPV systems require an appropriate layout design that involves massive land utilization, thereby increasing the cost to function optimally. These consequences must be reduced if solar energy is to be implemented and adopted worldwide. Therefore, this study attempt to mitigate these consequences by developing a computational algorithm in the MATLAB platform capable of precisely estimating and optimizing the levelized cost of electricity (LCOE) of a CPV field layout using local meteorological data. As a result, the proposed computational method can facilitate various stakeholders such as researchers and engineers to reduce the cost of implementing optimal layout design for CPV, simultaneously increasing the efficiency of generating solar power. Unlike previous works, this study also accounts for various factors that can potentially influence energy generation and cost (e.g., land cost, local meteorological data, geographical location, the land aspect ratio of CPV farms, etc.)

[the_background] =>

Effective space allocations in solar farms are crucial since inappropriate space design of concentrator photovoltaic (CPV) systems can cause optical losses due to the shadowing between adjacent CPV systems. Thus, capable of leading to the deterioration of the overall electrical generation of solar power plants (SPP). Such an issue can be overcome by increasing the separation distance between the adjacent CPV systems, implying a possible increase in land-related costs due to ineffective land use. Therefore, this study focused on optimizing the layout design optimization in the SPP to attain the best trade-off between land usage and energy generation using a computational algorithm.

[the_sdg_impact] =>

According to the US government agency, Office of Energy Efficiency and Renewable Energy, the US solar power capacity has grown to an estimated 97.2 gigawatts (GW). The International Energy Agency also projects solar energy to provide 4% of the total global electricity demand by 2023. Hence, the growing popularity of solar energy calls to attention the need for effectively designed SPP layouts to cater to this demand. This research simultaneously demonstrates its impact on UNSDG 7: Affordable and Clean Energy in contributing to this solution. It enables the accessibility and affordability of solar power by reducing costs incurred during solar power installations. Furthermore, this research potentially improves solar power generation, thereby increasing the use of renewable energy and improving global energy efficiency.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0038092X20305181?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Power-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16127994_1653280016.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.solener.2020.05.032 [original_article_reference_fields] => Array ( [publication_title] => Optimization study of solar farm layout for concentrator photovoltaic system on azimuth-elevation sun-tracker [journal_title] => Solar Energy [publisher] => Elsevier [year] => July 2020 [subject] => Environmental Engineering; Solar Power ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [56] => WP_Post Object ( [ID] => 33282 [post_author] => 154 [post_date] => 2022-05-23 12:16:47 [post_date_gmt] => 2022-05-23 04:16:47 [post_content] => [post_title] => Solving Deep Learning’s Overfitting via Batch Contrastive Regularization [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => solving-deep-learnings-overfitting-via-batch-contrastive-regularization [to_ping] => [pinged] => [post_modified] => 2022-05-23 12:16:47 [post_modified_gmt] => 2022-05-23 04:16:47 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33282 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TAN, Hung Khoon [researchers_position] => Department of Computer Science, Faculty of Information and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile] => https://www.researchgate.net/profile/Hung-Khoon-Tan-3 [researchers_second_profile] => https://orcid.org/0000-0001-9964-7186 ) [researchers_info_2] => Array ( [researchers_name_2] => TANVEER, Muhammad [researchers_position_2] => Department of Computer Science, Faculty of Information and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Batch contrastive loss; batch regularization; center-level contrastive loss; sample-level contrastive loss; multicenter loss; neural network [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/access-gagraphic-3110286.jpg [figures] => [video] => [the_novelty] =>

This study proposed a new regularization technique known as batch contrastive regularization to address the overfitting issues in deep neural networks. When the system additionally learns to compare the similarity between similar images and dissimilarity between two unrelated images, it performs better on unseen samples, not only on training samples. The three contrastive losses involved in improving the generalization performance were centroid contrastive loss, sample contrastive loss, and multicenter loss. The two-headed network could speed up multi-task learning by having one head for classification and the other for regularization. Evaluation using the CIFAR-10 and CIFAR-100 datasets showed over 11% improvement for ResNet50 on CIFAR-100.

[the_background] =>

Overfitting happens whereby a system performs very well on the training set but poorly when deployed. Deeper neural networks have more parameters and would be overfitting, especially when training samples are insufficient. Previously, regularization techniques failed to enrich the model because the cross-sample information was not considered. Meanwhile, although contrastive-based regularization is promising, several limitations were identified. For the first time, an in-depth study was conducted to understand batch loss regularization for general classification tasks.

[the_sdg_impact] =>

Deep learning is a disruptive technology that revolutionizes many industries. It is estimated to improve 82% of the outcome metric of SDG, including manufacturing (SDG9), climate action (SDG13), and sustainable city (SDG11). There is a need to improve the way deep learning models are trained to build more effective DL systems.

[article_url] => https://ieeexplore.ieee.org/document/9529219 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Neural-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16127772_1653279105.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1109/ACCESS.2021.3110286 [original_article_reference_fields] => Array ( [publication_title] => Regularization of Deep Neural Network With Batch Contrastive Loss [journal_title] => IEEE Access [publisher] => IEEE Explore [year] => September 2021 [subject] => Computer Science; Information Technology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [57] => WP_Post Object ( [ID] => 33265 [post_author] => 154 [post_date] => 2022-05-23 11:55:31 [post_date_gmt] => 2022-05-23 03:55:31 [post_content] => [post_title] => Boosting Well-Being via Creativity [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => boosting-well-being-via-creativity [to_ping] => [pinged] => [post_modified] => 2022-05-23 11:55:31 [post_modified_gmt] => 2022-05-23 03:55:31 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33265 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TAN, Chee Seng [researchers_position] => Department of Psychology and Counselling, Faculty of Arts and Social Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Creativity.png [researchers_profile] => https://www.researchgate.net/profile/Chee-Seng-Tan [researchers_second_profile] => https://orcid.org/0000-0003-2474-6942 ) [researchers_info_2] => Array ( [researchers_name_2] => TAN, Cher Yi [researchers_position_2] => Department of Psychology and Counselling, Faculty of Arts and Social Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-1372-8661 ) [original_article_reference] => [research_footprints] => creativity; employees; experiment; priming; subjective well-being [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This research reported the beneficial effect of creativity on subjective well-being in two studies. The first study showed that undergraduate students and working adults with higher creativity had self-reported a higher level of well-being. Then, a subsequent study was conducted to further study the causal relationship between creativity and well-being. The second study indicated that participants who recalled their past creative achievement showed a higher level of well-being. Based on the proven bidirectional relationship between creativity and well-being, future research should consider the significance of a reciprocal relationship between two constructs.

[the_background] =>

Although well-being is known to promote creativity, there are insufficient in-depth studies on the effect of creativity on well-being. Meanwhile, subjective well-being focuses on both positive and negative aspects of life as well as satisfaction with life. It is different from proxies, like happiness, psychological/emotional well-being, which focuses on the positive dimension. Also, creativity is being perceived differently due to cultural differences, especially between the East and West. This study examined the positive effect of creativity on subjective well-being in the Malaysian context to address those differences.

[the_sdg_impact] =>

Subjective well-being is useful in appraising the well-being of populations. Meanwhile, there has been increasing acknowledgment of mental health's important role in achieving global development goals. In order to fulfill UNSDG 3 (Good health and well-being)'s vision of improving physical and psychological wellness, this study demonstrates that creativity is a promising factor to enhance well-being among young adults and working adults.

[article_url] => https://www.mdpi.com/1660-4601/18/14/7244 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Creativity-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16127549_1653277811.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.3390/ijerph18147244 [original_article_reference_fields] => Array ( [publication_title] => Being Creative Makes You Happier: The Positive Effect of Creativity on Subjective Well-Being [journal_title] => International Journal of Environmental Research and Public Health [publisher] => MDPI [year] => July 2021 [subject] => Psychology and Counselling; Social Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [58] => WP_Post Object ( [ID] => 33244 [post_author] => 154 [post_date] => 2022-05-23 11:39:43 [post_date_gmt] => 2022-05-23 03:39:43 [post_content] => [post_title] => Derivation of Operational Status from Retrofitted Sensor [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => derivation-of-operational-status-from-retrofitted-sensor [to_ping] => [pinged] => [post_modified] => 2022-05-23 11:39:43 [post_modified_gmt] => 2022-05-23 03:39:43 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33244 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => OOI, Boon Yaik [researchers_position] => Department of Computer Science, Faculty of Information and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Sensor.png [researchers_profile] => https://www.researchgate.net/profile/Yaik-Ooi [researchers_second_profile] => https://orcid.org/my-orcid?orcid=0000-0002-5230-671X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Industry 4.0; Internet of Things (IoT) for manufacturing; legacy machine monitoring; vibration analysis [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study developed an approach to automatically track and distinguish various operation statuses of legacy manufacturing machines by analyzing the vibration data collected from a retrofitted wireless vibration sensor. To test its feasibility, the parameter-free Internet-of-Things (IoT) approach was deployed on a 3-speed industrial exhaust fan in a limestone processing factory. The operation status was successfully tracked with average accuracy and standard uncertainty of 98.6% and 1.06%, respectively. This promising approach could be applied to other factories, such as palm oil refineries and concrete plants.

[the_background] =>

While riding the wave of Industrial Revolution (IR) 4.0, data plays a crucial role in decision-making in every business sector. However, many small and medium enterprises (SME) factories still use manufacturing machines without any computing function, let alone internet connectivity. This implies that access to operational data is limited and painstaking. To help these SMEs catch up with the IR 4.0, this study designed an end-to-end wireless IoT and parameter-free approach to capture and analyze vibration data, which outputs critical operational status. By having these data, stakeholders of the business will have a clear understanding of their machines' productivity to make better business decisions.

[the_sdg_impact] =>

In manufacturing, big data can include data collected at every production stage, including data from machines, devices, and operators. The data serves as a reliable guide for business planning and strategy with proper analysis and interpretation. Besides getting prepared for IR 4.0, the sensor retrofitting solution developed by this study also helps SMEs attain better operation visibility (UNSDG 9: Industry, Innovation & Infrastructure).

[article_url] => https://ieeexplore.ieee.org/document/9093061 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Sensor3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16127135_1653276323.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1109/JIOT.2020.2994395 [original_article_reference_fields] => Array ( [publication_title] => A Parameter-Free Vibration Analysis Solution for Legacy Manufacturing Machines’ Operation Tracking [journal_title] => IEEE Internet of Things Journal [publisher] => IEEE Explore [year] => May 2020 [subject] => Computer Science; Information Technology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [59] => WP_Post Object ( [ID] => 33224 [post_author] => 154 [post_date] => 2022-05-23 11:05:25 [post_date_gmt] => 2022-05-23 03:05:25 [post_content] => [post_title] => Factors that Influence Switching Intention from Cash to Mobile Payment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => factors-that-influence-switching-intention-from-cash-to-mobile-payment [to_ping] => [pinged] => [post_modified] => 2022-05-23 11:05:25 [post_modified_gmt] => 2022-05-23 03:05:25 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33224 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LEE, Voon-Hsien [researchers_position] => Department of Marketing, Faculty of Business and Finance, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/cashless.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-8723-8219 ) [researchers_info_2] => Array ( [researchers_name_2] => LOH, Xiu Ming [researchers_position_2] => Department of Marketing, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/cashless-2.png [researchers_profile_2] => [researchers_second_profile_2] => "https://orcid.org/ 0000-0003-0649-9183" ) [original_article_reference] => [research_footprints] => Mobile Payment; Switching Intention; Push-pull-mooring; Status quo bias; Mobile Commerce [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study determined the factors that play vital roles in the consumers' decision-making to transition from cash to m-payment. This was done via a uniquely developed conceptual model that incorporated the push-pull-mooring (PPM) framework with the perspective of status quo bias (SQB). The studied parameters were monetary value, alternative attractiveness, trust, perceived security and privacy, switching costs, traditional payment habit, and inertia. Results suggest all but two of the developed hypotheses were statically supported. This could be because most respondents do not use mobile payments daily. Thus, the cumulative financial savings would be difficult to be noticed by mobile payment users in such a situation. In conclusion, with the increase in mobile payment adoption and decrease in cash usage, cash costs can be decreased. These costs include the printing, storing, and distributing cash spent by the banks and government. These savings can provide the government with excess funds, which can be diverted to develop other sectors of the country's economy.

[the_background] =>

The Malaysian government has consistently promoted mobile payment adoption due to its numerous benefits and advantages, including enhancing customers' checkout experience. However, consumers in Malaysia still find it more comfortable using cash to make payments for goods and services despite initiatives to shift Malaysia into a cashless society. Apparently, cash is still king among the payment methods available despite the urge from authorities. Hence, this study looks into the factors influencing switching intention from cash to mobile payment.

[the_sdg_impact] =>

In Malaysia, there is a solid foundation for m-payment to thrive as the number of mobile connections in terms of the total population is at 125% (We Are Social, 2019). In fact, the Central Bank of Malaysia has been trying to accelerate the promotion of m-payment adoption as it recognizes the numerous benefits of m-payment (Bank Negara Malaysia, 2018). However, consumers have a certain level of hesitancy concerning these initiatives. Therefore, the outcome of this study contributes to SDG9: Industry, Innovation, and Infrastructure as it explores means to understand consumer behavior and willingness to adapt to the shifting payment method initiatives.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/INTR-04-2020-0175/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/cashless-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16126791_1653274717.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/INTR-04-2020-0175 [original_article_reference_fields] => Array ( [publication_title] => Switching from cash to mobile payment: what's the hold-up? [journal_title] => Internet Research [publisher] => Emerald Publishing [year] => February 2021 [subject] => Business; Marketing ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [60] => WP_Post Object ( [ID] => 33204 [post_author] => 154 [post_date] => 2022-05-23 10:50:40 [post_date_gmt] => 2022-05-23 02:50:40 [post_content] => [post_title] => New Path-Finding Strategy to Design Smarter Drones [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => new-path-finding-strategy-to-design-smarter-drones [to_ping] => [pinged] => [post_modified] => 2022-05-23 10:50:40 [post_modified_gmt] => 2022-05-23 02:50:40 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33204 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TAN, Lyk Yin [researchers_position] => "Faculty of Information and Communication Technology Department of Computer and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Drones.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-0277-833X ) [researchers_info_2] => Array ( [researchers_name_2] => GOH, Hock Guan [researchers_position_2] => "Faculty of Information and Communication Technology Department of Computer and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Drones-2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0003-2416-5777 ) [original_article_reference] => [research_footprints] => Wireless network; mobile sink; efficient path; data collection [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study introduced a new path-finding strategy, known as Energy-efficiency Path-finding Strategy (EPS) in the Air-Ground Collaborative Wireless Sensor Network (AGCWSN), which could potentially enhance the efficiency of data collection for drones. Two phases were involved in this study, i.e., intermediate point selection phase and path selection phase. The intermediate points among the group sensor nodes allowed the drone to collect data rapidly (reduced flight distance). Generic Algorithm (GA) shortened the flight path generation time in the path selection phase. It archived the pre-set condition (e.g., maximized data collection and returned to the base station before its power was drained out). Compared to other existing data collection strategies, EPS achieved lower data delivery delay and better utilization of the mobile sink’s battery capacity, as simulations showed. These two major advantages could compensate for its higher packet loss percentage. By implementing this improvement, data collection efficiency in flight path generation and energy consumption for drones can be significantly enhanced.

[the_background] =>

Drones are being deployed into different industries to improve productivity and efficiency. For example, Amazon deploys drones in their delivery system to shorten the last-mile delivery process, while drones in sustainable agriculture can reduce the data collection delays. However, one of the main drawbacks is the limited battery capacity of the drone during its flight. In this study, the data collection process of a drone in agriculture will be further improved by optimizing the energy usage of the drones and by shortening the flight trajectory taken by the drones. Despite having several reported approaches which shortened the delays, the flight trajectory taken by the mobile sink has not been addressed yet. Thus, this study proposed a new path-finding strategy to overcome that.

[the_sdg_impact] =>

As industrialization advances rapidly, drones play essential roles in maximizing productivity. Their potential has been proven especially in goods delivery and sustainable agricultural activities. The solutions proposed by this research can boost the productivity and operating duration of drones. Therefore, it contributes to the materialization of UNSDG 9’s target, i.e., build resilient infrastructure, promote inclusive and sustainable industrialization, and foster innovation.

[article_url] => https://www.techscience.com/cmc/v67n3/41619 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Drones-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16126629_1653273989.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.32604/cmc.2021.015402 [original_article_reference_fields] => Array ( [publication_title] => An Energy-Efficient Mobile-Sink Path-Finding Strategy for UAV WSNs [journal_title] => Computers, Materials, & Continua [publisher] => Tech Science Press [year] => March 2021 [subject] => Information and Communication Technology; Drones ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [61] => WP_Post Object ( [ID] => 33187 [post_author] => 154 [post_date] => 2022-05-23 10:40:17 [post_date_gmt] => 2022-05-23 02:40:17 [post_content] => [post_title] => Transport EKC Analysis with Corruption as an Impacting Variable from 1990-2017 in Malaysia [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => transport-ekc-analysis-with-corruption-as-an-impacting-variable-from-1990-2017-in-malaysia [to_ping] => [pinged] => [post_modified] => 2022-05-24 09:37:13 [post_modified_gmt] => 2022-05-24 01:37:13 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33187 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GO, You How [researchers_position] => Department of Economics, Faculty of Business and Finance, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/corruption.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0003-1529-8885 ) [researchers_info_2] => Array ( [researchers_name_2] => LAU, Lin Sea [researchers_position_2] => Department of Economics and Administrative Sciences, Attar Institute of Higher Education, Iran [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0003-3981-4451 ) [original_article_reference] => [research_footprints] => Environmental Kuznets curve hypothesis; Carbon dioxide emissions; Transport sector; Corruption; Malaysia [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study intends to analyze the association between transport carbon dioxide (CO2) emission and corruption practice and validate the Environmental Kuznets curve (EKC) hypothesis in the Malaysian context. This study adopted fully modified ordinary least squares, canonical cointegrating regression, and dynamic ordinary least squares in performing long-run estimations to test the EKC hypothesis on the role of corruption on transport CO2 emission from 1990 to 2017 in the country. The retrospective study showed that transport CO2 emission increases directly proportionally to corruption, demonstrating environmental degradation that corruption causes. The research also identified that the EKC hypothesis does not apply in Malaysia, suggesting that the country has yet to attain the level of economic growth required to reduce greenhouse gas (GHG) emissions. The outcome of this study will be a significant tool for developing effective government policies to reduce transport CO2 emission with proper governance of the sector.

[the_background] =>

The transport sector is one of the major contributors to global CO2 emission, accounting for 24% of the total. In Malaysia, road transport contributes to 85.2% of the total transport emission. The local transport industry is largely intertwined with the government predisposing it to undesirable corruption practices, contributing to harmful environmental policies and misallocation of environmental resources. The outcome of this study showed such practices provide the precarious impact on the environment. If corruption is left uncontrolled, it will lead to a more harmful outcome in the long run. The study also made aware that Malaysia is far from attaining economic growth that can support CO2 emission mitigation due to the lack of advanced technology and widespread corruption in the transport sector. Hence, sustainable long-term efforts are needed to mitigate CO2 emissions from the transport industry. The efforts will include introducing stringent anti-corruption policies and laws, enhancing research and development in the transportation sector, and implementing the latest environmental-friendly technologies to reduce GHG emissions. This study is the first in the country to explore the impacts of transport EKC locally with corruption as an impacting factor, which has proven the importance of better governance on this matter.

[the_sdg_impact] =>

This study resonates very well with the United Nation's Sustainable Development Goal (UNSDG) 13: Climate Action. The specific target involved under the UNSDG is Target 13.2: Integrate climate change measures into national policies, strategies, and planning. Despite the study being conducted locally, the intention is applicable globally, given that climate change is an issue that is getting more attention on the global pedestal by day. The atmospheric concentrations of the major GHG continue to increase worldwide. To limit global warming to 1.5°C above pre-industrial levels following Paris Agreement, the world would need to attain net-zero carbon dioxide emissions by 2050. Locally, Malaysia's intention to cut GHG emissions by 45% by 2030 can only be achieved if the government develops a sustainable transport policy that optimally controls the traffic rate, enhances environmental performances, and creates public awareness on the impact of transport emission on the environment. Hence, this study is a wake-up call to the authorized agencies and public to do the needful to cut down GHG emissions in general to save the planet that has been home and provided us with everything.

[article_url] => https://link.springer.com/article/10.1007/s11356-020-10736-w [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/corruption-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16126498_1653273276.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s11356-020-10736-w [original_article_reference_fields] => Array ( [publication_title] => A transport environmental Kuznets curve analysis for Malaysia: exploring the role of corruption [journal_title] => Environmental Science and Pollution Research [publisher] => Springer Nature [year] => September 2020 [subject] => Economics; Environmental; Finance ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [62] => WP_Post Object ( [ID] => 33170 [post_author] => 154 [post_date] => 2022-05-23 10:25:28 [post_date_gmt] => 2022-05-23 02:25:28 [post_content] => [post_title] => The Intention to Adopt Solar Technology among Malaysian Consumers: Of Knowledge and Price Value [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => the-intention-to-adopt-solar-technology-among-malaysian-consumers-of-knowledge-and-price-value [to_ping] => [pinged] => [post_modified] => 2022-05-23 10:25:28 [post_modified_gmt] => 2022-05-23 02:25:28 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33170 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHOONG, Yuen Onn [researchers_position] => Department of Business and Public Administration, Faculty of Business and Finance, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Adopting.png [researchers_profile] => https://www.researchgate.net/profile/Yuen-Onn-Choong [researchers_second_profile] => https://orcid.org/0000-0002-6888-5285 ) [researchers_info_2] => Array ( [researchers_name_2] => LAU, Lin Sea [researchers_position_2] => Department of Economics and Administrative Sciences, Attar Institute of Higher Education, Iran [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0003-3981-4450 ) [original_article_reference] => [research_footprints] => Residential solar photovoltaic; Knowledge transmission; Price value; Sustainability; Unified theory of acceptance and use of technology (UTAUT); Social influence; Facilitating conditions [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Using one of the most established technology adoption theories, UTAUT (Unified Theory of Acceptance and Use of Technology), this research examines the behavioral intention of potential consumers' in adopting solar power technology. From a social influence perspective, the researchers discovered that cost perception has a more significant positive effect than knowledge. Social influence is also revealed to have a more substantial effect on consumers' behavioral intention than other conditions supporting innovation. However, these conditions positively mediate the relationship between social influence and behavioral intention. This research provides valuable insights into consumers' perspectives on renewable solar energy, which is limited since previous studies do not specifically address the solar energy context. These insights guide multiple stakeholders such as the Malaysian government and relevant commercial suppliers on successfully promoting the use of solar energy. Some strategies highlighted by the researchers include providing financial support and sufficient information to potential consumers as well as creating favorable impressions of technology use. Additionally, this research also prompts the need for effective policies that cater to the needs of large corporations and small households, encouraging the use of renewable technology in Malaysia by allowing stakeholders at every level to contribute to the nation's sustainability plan.

[the_background] =>

The increase in global population and economic development has also contributed to the significant boom in electrical consumption worldwide. While non-renewable energy sources are still expected to constitute 77% of the energy consumption in 2040, renewable energy has been gaining fast traction recently, with solar power being one of the most popular sources. However, the adoption rate for solar photovoltaic technology among households remains low, prompting the researchers to focus on the reasons that influence Malaysian consumers' intention to adopt solar energy. The research accounts for the consumers' perspective and examines the influence of the price and knowledge dimensions on consumers' intention to use solar energy.

[the_sdg_impact] =>

Globally, fossil fuels (e.g., coal and oil) account for 70% of the increasing demand for energy (International Energy Agency, 2017), while in Malaysia, fossil fuels generate 90.6% of the nation's total electricity. This situation calls for the successful implementation of solar energy as an alternative energy source since it is considered one of the most viable forms of renewable energy. In terms of global sustainability, this research contributes to the achievement of UNSDG 7: Affordable and Clean Energy. By focusing on consumers' views on cost and information sharing on solar power, this research provides stakeholders with insights for future strategies to promote access to solar power's affordable and reliable use. These insights can also reduce the dependency on fossil fuels to ensure energy efficiency and a balanced global energy mix. Additionally, the impact of this research is also observed in relation to UNSDG13: Climate Action, where it improves the overall awareness of climate change mitigation.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0301421520303827?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Adopting-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16126340_1653272497.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.enpol.2020.111651 [original_article_reference_fields] => Array ( [publication_title] => Investigating nonusers’ behavioural intention towards solar photovoltaic technology in Malaysia: The role of knowledge transmission and price value [journal_title] => Energy Policy [publisher] => Elsevier [year] => September 2020 [subject] => Business and Public Administration; Solar Energy ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [63] => WP_Post Object ( [ID] => 33118 [post_author] => 154 [post_date] => 2022-05-22 14:42:33 [post_date_gmt] => 2022-05-22 06:42:33 [post_content] => [post_title] => Extraordinary Solar Energy Conversion & Heat Storage by Phase Change Material [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => extraordinary-solar-energy-conversion-heat-storage-by-phase-change-material [to_ping] => [pinged] => [post_modified] => 2022-05-22 14:42:33 [post_modified_gmt] => 2022-05-22 06:42:33 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33118 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MUNUSAMY, Yamuna [researchers_position] => Department of Petrochemical Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile] => https://www.researchgate.net/profile/Yamuna-Manusamy [researchers_second_profile] => https://orcid.org/0000-0001-9123-7705 ) [researchers_info_2] => Array ( [researchers_name_2] => ONG, Kok Seng [researchers_position_2] => Department of Industrial Engineering, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile_2] => https://www.researchgate.net/profile/Ong-Kok-Seng [researchers_second_profile_2] => https://orcid.org/0000-0002-4413-2852 ) [original_article_reference] => [research_footprints] => Phase change material; Composite materials; Thermal properties; Energy storage; Conversion; Coating [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Unlike previous phase change material (PCM), which could only store heat, this study fabricated a PCM capable of solar energy conversion and heat storage. The visible light-harvesting PCM could absorb an enormous amount of heat and store the heat in the form of latent heat. As a result, only a smaller tank is required and eliminates solar collectors' usage. The fabrication involved dip-coating myristic acid (MA) tablets into layers of polymer coating solution with reduced graphene oxide (RGO). The highest heat storage, solar energy conversion, and storage efficiency (21%) were achieved by the light absorptive polymeric form-stable composite phase change tablet (RGO-PARB/MA) when loaded with 1.5 wt% RGO. The 1.5 wt% RGO-PARB/MA recorded up to 1,000 thermal cycles with less than 2% change in thermal properties. The new PCM can be further optimized to enhance the efficiency of existing solar heating systems.

[the_background] =>

The current solar water heater system uses sensible heat storage that involves a large mass of water. Since most roofs are not meant to support such load, the storage has to be built on the ground instead. This setup will, in turn, require a circulation system which ends up lowering the energy-saving efficiency. Meanwhile, PCM is suitable for thermal energy storage in solar heating systems due to its high thermal storage density and minimal temperature variation. Despite various studies focusing on improving the light absorption of PCM via the addition of light absorptive materials, there was no quantitative measurement conducted to derive the solar energy conversion and storage efficiency. Hence, besides fabricating a PCM loaded with reduced graphene oxide (RGO), this study also built a new in-house experimental setup to carry out the crucial quantitative characterizations.

[the_sdg_impact] =>

Renewable energy is essential to reduce the emission of greenhouse gases and to overcome pollution. This implies the urgent need for a superior energy storage system. The PCM developed in this research could set new benchmarks for solar water heater systems, benefitting both the environment and its consumers. Therefore, it aligns with the targets of UNSDG 7: Affordable & Clean Energy.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S135943111931453X?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Solar-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16111096_1653201441.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.applthermaleng.2019.114673 [original_article_reference_fields] => Array ( [publication_title] => Light absorptive polymeric form-stable composite phase change material for thermal storage [journal_title] => Applied Thermal Engineering [publisher] => Elsevier [year] => May 2020 [subject] => Petrochemical Engineering; Engineering and Green Technology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [64] => WP_Post Object ( [ID] => 33101 [post_author] => 154 [post_date] => 2022-05-22 14:27:25 [post_date_gmt] => 2022-05-22 06:27:25 [post_content] => [post_title] => Seaweed-Probiotic Blend to Increase Survival Rate of Shrimp [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => seaweed-probiotic-blend-to-increase-survival-rate-of-shrimp [to_ping] => [pinged] => [post_modified] => 2022-07-05 10:52:39 [post_modified_gmt] => 2022-07-05 02:52:39 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33101 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WONG, Wey Lim [researchers_position] => Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Shrimp.png [researchers_profile] => https://www.researchgate.net/profile/Wey-Lim-Wong [researchers_second_profile] => "https://orcid.org/ 0000-0002-2722-3517" ) [researchers_info_2] => Array ( [researchers_name_2] => LOO, Keat Wei [researchers_position_2] => Department of Biological Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile_2] => https://www.researchgate.net/profile/Loo-Keat-Wei [researchers_second_profile_2] => "https://orcid.org/ 0000-0003-1853-0352" ) [original_article_reference] => [research_footprints] => Antimicrobial; Early mortality syndrome; Probiotic; Seaweed; Shrimp; Synergistic [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study disclosed a shrimp feed formulation, a seaweed-probiotic blend, which could help shrimps resist acute hepatopancreatic necrosis disease (AHPND). The seaweed-probiotic blend was a combination of Bacillus species and the red seaweed, Gracilaria sp. Through in vitro studies, the seaweed-probiotic blend exhibited a synergistic antimicrobial effect against the AHPND-causing V. parahaemolyticus strain. Consistent in vivo results were obtained whereby shrimps fed with the blend were able to survive under the presence of Vibrio parahaemolyticus strain. This environmentally-friendly shrimp feed showed promising potential as an alternative to the antibiotics used in shrimp cultivation.

[the_background] =>

The whiteleg shrimp (Litopenaeus vannamei) is a well-known cultured shrimp. However, shrimp production was greatly reduced when AHPND caused mass mortality in the shrimp culture. Although antibiotics and probiotics are commonly used in controlling this bacterial shrimp disease, excessive use of antibiotics could adversely affect human health and environment. In developing natural alternatives to replace antibiotics, probiotics are known to be a suitable candidate. On the downside, the probiotics used are generally not of shrimp origin and, thus, reduce the efficiency of the probiotics in protecting the shrimps from pathogen infection. Meanwhile, the red seaweed, Gracilaria is a popular feed additive in Asia owing to its antibacterial effect. To have the best of both, this study investigated the antimicrobial effect of the combination of probiotics and seaweed against AHPND-causing V. parahaemolyticus. This combination has been shown to increase the survival of shrimp when the pathogens are introduced in the laboratory culture.

[the_sdg_impact] =>

Seafood prices keep soaring due to the increasing consumer demand. Reducing shrimp mortality due to bacterial diseases can improve shrimp supply in the market and, hence, provide high-quality and safe proteins to people. By proposing a sustainable method to lower shrimp mortality, this study contributes to the realization of UNSDG 2: Zero Hunger.

[article_url] => https://link.springer.com/article/10.1007/s12602-019-09616-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/shrimp5.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110961_1653200553.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s12602-019-09616-8 [original_article_reference_fields] => Array ( [publication_title] => Synergistic Antimicrobial Effect of a Seaweed-Probiotic Blend Against Acute Hepatopancreatic Necrosis Disease (AHPND)-Causing Vibrio parahaemolyticus [journal_title] => Probiotics and Antimicrobial Proteins [publisher] => Springer Nature [year] => November 2019 [subject] => Biological Science; Probiotics ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [65] => WP_Post Object ( [ID] => 33084 [post_author] => 154 [post_date] => 2022-05-22 14:12:16 [post_date_gmt] => 2022-05-22 06:12:16 [post_content] => [post_title] => Jackfruit’s Peptide JFS-2 – A Promising Antioxidant [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => jackfruits-peptide-jfs-2-a-promising-antioxidant [to_ping] => [pinged] => [post_modified] => 2022-05-22 14:12:16 [post_modified_gmt] => 2022-05-22 06:12:16 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33084 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WONG, Fai Chu [researchers_position] => Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Jackfruit.png [researchers_profile] => [researchers_second_profile] => Https://orcid.org/0000-0003-2259-1617 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Arginine; Artocarpus heterophyllus; Antioxidant peptide; Diet supplement; Electrostatic interaction; Hydrogen bond; Hydrophobicity; Synergistic [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study has successfully identified two antioxidant peptide sequences from jackfruit seeds. Both peptides, JFS-1 and JFS-2, exhibited protein protection potentials, whereas only Peptide JFS-2 displayed antioxidant activity. The antioxidant properties of Peptide JFS-2 were further investigated against different pH, temperature, and gastrointestinal digestion. Results indicated that Peptide JFS-2 was a suitable candidate to be used as a food preservative agent. Future studies on the peptides may map their antioxidant properties to a wider range of industrial applications.

[the_background] =>

Jackfruit seeds contain higher protein contents compared to the pulp. However, the antioxidant peptides derived from jackfruit seeds have yet to be identified. On the other hand, bioactivities were observed in protein hydrolysates and bioactive peptides derived from natural sources. Therefore, this study attempted to identify and examine the bioactive peptides extracted from jackfruit seeds. Results indicated that the peptides were potential antioxidants. These findings paved the path for future studies exploring stronger natural antioxidants.

[the_sdg_impact] =>

Studies have shown that various serious diseases (e.g., cancers) could be prevented by having a diet rich in antioxidants, primarily provided by fruits and vegetables. Furthermore, such a diet is unlikely to cause any severe side effects. By highlighting the possibilities and feasible ways to benefit from antioxidants in fruits, this study well aligns with UNSDG 3: Good health & well-being.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0308814620317386?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Jackfruit-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110828_1653199497.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.foodchem.2020.127876 [original_article_reference_fields] => Array ( [publication_title] => Identification of antioxidant peptides derived from tropical jackfruit seed and investigation of the stability profiles [journal_title] => Food Chemistry [publisher] => Elsevier [year] => March 2021 [subject] => Chemical Science; Food Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [66] => WP_Post Object ( [ID] => 33064 [post_author] => 154 [post_date] => 2022-05-22 13:55:45 [post_date_gmt] => 2022-05-22 05:55:45 [post_content] => [post_title] => Highly-Potential Anti-Chikungunya Virus Agents [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => highly-potential-anti-chikungunya-virus-agents [to_ping] => [pinged] => [post_modified] => 2022-05-22 13:55:45 [post_modified_gmt] => 2022-05-22 05:55:45 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33064 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SIT, Nam Weng [researchers_position] => Department of Allied Health Sciences, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Chikungunya.png [researchers_profile] => https://www.researchgate.net/profile/Sit-Nw [researchers_second_profile] => https://orcid.org/0000-0002-5949-491X ) [researchers_info_2] => Array ( [researchers_name_2] => CHAN, Sze Mun [researchers_position_2] => Department of Allied Health Sciences, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Chikungunya-2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-7820-595X ) [original_article_reference] => [research_footprints] => sequential solvent extraction; cytotoxicity; real-time RT-PCR; Vero cell; viral load; chikungunya; alphavirus; antiviral [graphic_abstract] => [figures] => [video] => [the_novelty] =>

The study identified several extracts from 8 plants with strong antiviral activity and different action modes against the Chikungunya virus. These include preventing virus entry, reducing or killing virus propagation, or even preventing further spread of the virus in the host. The modes of action were predicated by plant species and type of extractant. Infected African monkey kidney epithelial cells were used to conduct in vitro studies by applying concurrent and non-concurrent sample introduction modes. In the concurrent mode, it was observed that more extracts exhibited strong antiviral activity. Future studies should focus on the isolation of bioactive compounds as well as the mode of action.

[the_background] =>

Chikungunya virus spreads through the bite of infected Aedes mosquitoes. Despite being present in 114 countries and territories, there is still no effective remedy to fight the Chikungunya virus. Medicinal plants are valuable for their phytochemicals. Furthermore, they are well-known for their antiviral activities, which could tackle diseases including influenza, human immunodeficiency, and dengue virus. To address the urgent need for anti-chikungunya virus agents, this study aims to evaluate 132 extracts from 21 species of medicinal plants (from Malaysia) for antiviral activity against the Chikungunya virus. These findings implied that the full potential of medicinal plants has yet to be unveiled.

[the_sdg_impact] =>

Chikungunya virus was first described in the 1950s, but no licensed vaccine or specific drug has been developed to overcome the virus. Hence, there is no vaccine or specific antiviral treatment available to date. The output of this research serves as significant progress to meet the demand. Such an attempt to combat infectious diseases aligns well with the targets of UNSDG 3: Good health & well-being.

[article_url] => https://www.mdpi.com/2223-7747/10/8/1658 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Chikungunya-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110766_1653198738.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.3390/plants10081658 [original_article_reference_fields] => Array ( [publication_title] => Mode-Dependent Antiviral Activity of Medicinal Plant Extracts against the Mosquito-Borne Chikungunya Virus [journal_title] => Plants [publisher] => MDPI [year] => August 2021 [subject] => Allied Health Sciences; Medicine; Chikungunya Virus ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [67] => WP_Post Object ( [ID] => 33041 [post_author] => 154 [post_date] => 2022-05-22 13:45:52 [post_date_gmt] => 2022-05-22 05:45:52 [post_content] => [post_title] => Nanocomposite Photocatalyst with Dual-Action in Water Sanitation [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => nanocomposite-photocatalyst-with-dual-action-in-water-sanitation [to_ping] => [pinged] => [post_modified] => 2022-05-22 13:45:52 [post_modified_gmt] => 2022-05-22 05:45:52 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33041 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SIN, Jin Chung [researchers_position] => Department of Petrochemical Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Nanocomposite.png [researchers_profile] => https://www.researchgate.net/profile/Jin-Chung-Sin [researchers_second_profile] => http://orcid.org/0000-0002-1177-5894 ) [researchers_info_2] => Array ( [researchers_name_2] => LAM, Sze Mun [researchers_position_2] => Department of Environmental Engineering, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Nanocomposite-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Sze-Mun-Lam [researchers_second_profile_2] => http://orcid.org/0000-0001-5118-8144 ) [original_article_reference] => [research_footprints] => N-doped BiOBr; NiFe2O4Z-scheme; Photocatalytic degradation; Cr(VI) reduction [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S0169433221010424-ga1.jpg [figures] => [video] => [the_novelty] =>

This study has successfully synthesized Z-scheme N-BiOBr/NiFe2O4 nanocomposites which acted as photocatalysts under visible light. The highest photocatalytic activity was achieved when the nanocomposite contained 15%wt of NiFe2O4. Upon 60-min irradiation, the N-BiOBr/ NiFe2O4-15 nanocomposite removed 95.9% phenol and 100% Cr(VI). Besides being magnetically separable, the nanocomposite photocatalyst could be reused up to five successive runs without compromising its catalytic efficiency. These results indicated that N-BiOBr/ NiFe2O4-15 is a new promising catalyst for environmental and energy applications.

[the_background] =>

Water pollution has been an alarming side-effect owing to rapid development and industrialization. The pollutants mainly comprise organic compounds and heavy metals. Past studies show that BiOBr semiconductor is a potential photocatalyst whereby its response range could be improved via nonmetallic species doping. Meanwhile, NiFe2O4 ferrite is a popular photocatalyst for which its photocatalytic efficiency can be enhanced via coupling with semiconductor materials to form Z-scheme heterojunction. Since there is no existing literature from the past that has focused on the coupling of NiFe2O4 with N-BiOBr, this study aimed to synthesize N-BiOBr/ NiFe2O4 nanocomposite and explore its potential in removing organic pollutants and heavy metals. This serves as a good reference for future studies related to advanced photocatalysis technology for environmental and energy applications.

[the_sdg_impact] =>

WHO foresees that, by 2025, half of the world’s population will be living in water-stressed areas. Therefore, it is of utmost importance to develop new technologies to facilitate water sanitation and ensure a sustainable supply of clean water, which is also a source of affordable and clean energy. With the newly developed photocatalyst, this study contributes to improving water quality via pollution reduction (UNSDG 6: Clean Water & Sanitation).

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0169433221010424?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Nanocomposite-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110595_1653197066.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.apsusc.2021.149966 [original_article_reference_fields] => Array ( [publication_title] => Magnetic NiFe2O4 nanoparticles decorated on N-doped BiOBr nanosheets for expeditious visible light photocatalytic phenol degradation and hexavalent chromium reduction via a Z-scheme heterojunction mechanism [journal_title] => Applied Surface Science [publisher] => Elsevier [year] => September 2021 [subject] => Petrochemical Engineering; Engineering and Green Technology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [68] => WP_Post Object ( [ID] => 33024 [post_author] => 154 [post_date] => 2022-05-22 13:11:29 [post_date_gmt] => 2022-05-22 05:11:29 [post_content] => [post_title] => Superior Antibacterial Potential of Stingless Bee Honey [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => superior-antibacterial-potential-of-stingless-bee-honey [to_ping] => [pinged] => [post_modified] => 2022-05-22 13:12:46 [post_modified_gmt] => 2022-05-22 05:12:46 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33024 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NG, Wen Jie [researchers_position] => Department of Allied Health Sciences, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Medicinal.png [researchers_profile] => https://www.researchgate.net/profile/Wen-Jie-Ng [researchers_second_profile] => https://orcid.org/0000-0002-5971-250X ) [researchers_info_2] => Array ( [researchers_name_2] => SIT, Nam Weng [researchers_position_2] => Department of Allied Health Sciences, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile_2] => https://www.researchgate.net/profile/Sit-Nw [researchers_second_profile_2] => https://orcid.org/0000-0002-5949-491X ) [original_article_reference] => [research_footprints] => blossom honey; honeydew; Apis cerana; Geniotrigona; Heterotrigona; agar-well diffusion; bactericidal; endotoxin; synergistic; antibiotic resistant [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study demonstrated the extraordinary antibacterial effect of honeydew honey produced by Heterotrigona itama stingless bee. The honeydew honey exhibited antibacterial activity, including inhibitory and bactericidal effects against antibiotic-resistant strains, such as Staphylococcus aureus and Escherichia coli, in in vitro studies. Such prominent antibacterial effect of stingless bee honeydew honey was due to the interactive actions of hyperosmolarity, acidity, hydrogen peroxide, and phytochemicals together in honey. Compared to honey bee honey, stingless bee honey showed a higher success rate in bacteria inhibition, which can be further enhanced when combined with antibiotics. Due to its superior antibacterial properties, H. itama stingless bee honey is a promising natural remedy for treating bacterial infections. Hence, this product can be considered and promoted as a potential wound dressing in the health care sector.

[the_background] =>

Past studies reported that the antibacterial effects of honeydew honey are more superior to that of blossom honey. However, to date, the antibacterial potential of honeydew honey produced by Heterotrigona itama stingless bees from Malaysia is still ambiguous. Furthermore, only two types of honey (i.e., manuka honey and Revamil honey) are approved for medicinal use to treat infections. Thus, this study aimed to determine the potential of H. itama stingless bee honeydew honey as an antibacterial agent. So far, the studies on Malaysian stingless bee honey, especially honeydew honey, are rather limited. Hence, this investigation is useful to provide information about the antibacterial properties of this honey.

[the_sdg_impact] =>

As bacteria keep evolving to resist antibiotics, WHO has identified a list of bacteria for which new antibiotics are urgently needed. Honey is well-known for being an effective natural antibacterial food. Apart from being a sweetener, findings show that H. itama stingless bee honeydew honey can be promoted as a health-promoting food. With this achievement, this study supports the research and development of medicines for communicable and non-communicable diseases (UNSDG 3: Good health & well-being).

[article_url] => https://www.mdpi.com/2079-6382/9/12/871 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Medicinal-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110457_1653196083.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.3390/antibiotics9120871 [original_article_reference_fields] => Array ( [publication_title] => The Antibacterial Potential of Honeydew Honey Produced by Stingless Bee (Heterotrigona itama) against Antibiotic Resistant Bacteria [journal_title] => Antibiotics [publisher] => MDPI [year] => December 2020 [subject] => Allied Health Sciences; Medicine ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [69] => WP_Post Object ( [ID] => 33003 [post_author] => 154 [post_date] => 2022-05-22 13:01:55 [post_date_gmt] => 2022-05-22 05:01:55 [post_content] => [post_title] => Effective Model for Financial Performance Assessment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => effective-model-for-financial-performance-assessment [to_ping] => [pinged] => [post_modified] => 2022-05-22 13:01:55 [post_modified_gmt] => 2022-05-22 05:01:55 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=33003 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LAM, Weng Siew [researchers_position] => Department of Physical and Mathematical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Model.png [researchers_profile] => https://www.researchgate.net/profile/Weng-Siew-Lam [researchers_second_profile] => https://orcid.org/0000-0002-9850-4850 ) [researchers_info_2] => Array ( [researchers_name_2] => LAM, Weng Hoe [researchers_position_2] => Department of Physical and Mathematical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Model-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Weng-Hoe-Lam [researchers_second_profile_2] => https://orcid.org/0000-0002-7766-9170 ) [original_article_reference] => [research_footprints] => entropy; fuzzy VIKOR; multi-criteria decision making; financial ratio; research framework [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study introduced a multi-criteria decision-making (MCDM) method, known as the integrated entropy–fuzzy VIKOR model, which was feasible in assessing the financial performance of construction companies. Using this model, ECONBHD was identified as the best construction company in Malaysia in terms of financial performance. Current ratio (CR), debt to equity ratio (DER), and debt to asset ratio (DAR) were the most significant financial ratios which determined the financial performance. With its proven effectiveness, the integrated entropy–fuzzy VIKOR model could be applied in other economic sectors and be extended to other MCDM problems, such as supplier selection.

[the_background] =>

The construction industry in Malaysia has been making significant contributions to the country’s economic growth. However, the COVID-19 pandemic has caused major disruption to most construction projects, which in turn affected the financial performance of construction firms. Therefore, during this period, precise financial performance evaluation is essential to help the construction companies make proper decisions. The VIKOR model has been commonly used in evaluating financial performance. Despite that, it has drawbacks, especially in setting decision criteria weight. To date, there is no study conducted to investigate the financial performance among construction companies by integrating entropy and fuzzy approaches into the VIKOR model. To address the gap, this research proposed an MCDM model, known as entropy–fuzzy VIKOR model, to evaluate and compare the financial performance of several construction companies.

[the_sdg_impact] =>

Uncertainties, such as the COVID-19 pandemic, are influential in decision-making processes that directly affect the performance of businesses. Considering such uncertainties, a multi-criteria decision-making method is needed to accurately evaluate the financial performance of companies. The integrated entropy–fuzzy VIKOR model has been proven to be feasible for such a purpose. Thus, this study achieves UNSDG 9: Industry, Innovation & Infrastructure through enhancing scientific research

[article_url] => https://www.mdpi.com/1099-4300/23/3/320 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Model-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110358_1653195464.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.3390/e23030320 [original_article_reference_fields] => Array ( [publication_title] => Performance Evaluation of Construction Companies Using Integrated Entropy–Fuzzy VIKOR Model [journal_title] => Entropy [publisher] => MDPI [year] => March 2021 [subject] => Physical and Mathematical Science; Business ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [70] => WP_Post Object ( [ID] => 32983 [post_author] => 154 [post_date] => 2022-05-22 12:31:28 [post_date_gmt] => 2022-05-22 04:31:28 [post_content] => [post_title] => G. Changii Seaweed in Counteracting BPA-induced Adverse Effects [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => g-changii-seaweed-in-counteracting-bpa-induced-adverse-effects [to_ping] => [pinged] => [post_modified] => 2022-05-22 12:31:28 [post_modified_gmt] => 2022-05-22 04:31:28 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32983 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KWONG, Phek Jin [researchers_position] => Department of Agricultural and Food Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Seaweed.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-2320-671X ) [researchers_info_2] => Array ( [researchers_name_2] => TAN, Gim Cheong [researchers_position_2] => Department of Allied Health Sciences, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Seaweed-2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-8068-1648 ) [original_article_reference] => [research_footprints] => Red seaweed; Gracilaria changii; Antioxidant; Endocrine disruptor; Bisphenol A; Reproduction [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study discovered the ability of seaweed (Gracilaria changii) extract in protecting the reproductive system of mammals from the potential adverse effects of bisphenol A (BPA). Aqueous extraction of G. changii exhibited superior antioxidant properties, surpassing that of methanol and ethanol extraction approaches. Through in vivo studies using mice exposed to BPA, improved uterine development and chances of conceiving were among the remarkable findings reported. Future studies should focus on identifying the specific bioactive compounds from this aqueous extract of G. changii to further explore its mechanism of action in counteracting the BPA at the molecular level.

[the_background] =>

Gracilaria changii is a type of seaweed that is often used in food production. Besides being rich in nutrients crucial for human reproduction, G. changii is also known as a strong antioxidant. Meanwhile, plasticizer bisphenol A (BPA) was proven to cause oxidative damage to the human reproductive system and pregnancy. Hence, this study was conducted to investigate the potential of G. changii extract in mitigating BPA-induced adverse effects on female reproductive function. The potential of G. changii extract as a protection against BPA was proved. These results are valuable in overcoming conceiving problems associated with plasticizer toxicity.

[the_sdg_impact] =>

The global fertility rate has halved over the past 50 years (ourworldindata.org). This phenomenon is partially attributed to a hostile environment. By developing an effective solution to counter the negative effect, this study fulfills UNSDG 3.9 in substantially reducing the number of illnesses from hazardous chemicals.

[article_url] => https://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=1;spage=34;epage=43;aulast=Ng [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Seaweed-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110130_1653193595.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.4103/1995-7645.304299 [original_article_reference_fields] => Array ( [publication_title] => Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice [journal_title] => Asian Pacific Journal of Tropical Medicine [publisher] => Hainan Medical University [year] => January 2021 [subject] => Agricultural and Food Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [71] => WP_Post Object ( [ID] => 32963 [post_author] => 154 [post_date] => 2022-05-19 19:57:12 [post_date_gmt] => 2022-05-19 11:57:12 [post_content] => [post_title] => Family Perception & Life of Refugee Children in Malaysia [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => family-perception-life-of-refugee-children-in-malaysia [to_ping] => [pinged] => [post_modified] => 2022-05-22 12:18:55 [post_modified_gmt] => 2022-05-22 04:18:55 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32963 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KHOR, Kheng Kia [researchers_position] => Department of Advertising, Faculty of Arts and Social Science, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Refugee.png [researchers_profile] => https://www.researchgate.net/profile/Khengkia-Khor-2 [researchers_second_profile] => https://orcid.org/0000-0003-0319-2303 ) [researchers_info_2] => Array ( [researchers_name_2] => KOK, Jin Kuan [researchers_position_2] => Department of Psychology, Universiti Tunku Abdul Rahman, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Refugee-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Jin-Kuan-Kok [researchers_second_profile_2] => https://orcid.org/0000-0003-2473-8862 ) [original_article_reference] => [research_footprints] => refugee children; collage life-story elicitation technique (CLET); narrative approach; self-striving [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study reported how refugee children perceived their family lives and coped with life as a refugee in Malaysia. The Collage Life-Story Elicitation Technique (CLET) and a discovery-oriented narrative approach were applied to interview 25 refugee children in Kuala Lumpur. Emotionally, these children felt isolated, lonely, and powerless. To them, a family carried the significance of both vulnerability as well as a source of strength. Besides receiving help from enabling adults and teachers, their coping mechanisms included self-empowerment by being brave and independent. Future studies could explore further insights by engaging these interviewees through focus groups and providing them with better welfare.

[the_background] =>

Refugees in Malaysia are marginalized and have no legal rights or protection. Furthermore, the majority of the refugee children have no access to education and are vulnerable to behavioral problems, mental health problems, and substance abuse. Meanwhile, research that focuses on the experiences and perceptions and the coping mechanisms of refugee children in Malaysia is rare. Thus, to improve the well-being of refugee children, this study was designed to fill up the existing knowledge gap. The research outcome proves that CLET is a potential eco-systematic approach to act as a key to better understanding the perception and emotion of refugee children in the process of rendering help.

[the_sdg_impact] =>

Refugee children in Malaysia are often marginalized in society, making them vulnerable and requiring special assistance in meeting their educational needs, mental health care, and socio-emotional well-being. Despite their status, the government should pay attention to their well-being to ensure healthy and inclusive development of the country. By sharing crucial insights about refugee children, this study aligns with UNSDG 3: Good health & well-being.

[article_url] => https://nsuworks.nova.edu/tqr/vol26/iss12/13/ [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Refugee-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16046926_1652961012.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.46743/2160-3715/2021.5114 [original_article_reference_fields] => Array ( [publication_title] => Refugee Children in Malaysia: Perceptions of Family and Coping Mechanisms [journal_title] => The Qualitative Report [publisher] => Nova Southeastern University Institutional Repository NSUWorks [year] => December 2021 [subject] => Social Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [72] => WP_Post Object ( [ID] => 32943 [post_author] => 154 [post_date] => 2022-05-19 13:10:43 [post_date_gmt] => 2022-05-19 05:10:43 [post_content] => [post_title] => Synthesis of Catalyst from Low-cost Biomass Waste Using 4-BDS Method [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => synthesis-of-catalyst-from-low-cost-biomass-waste-using-4-bds-method [to_ping] => [pinged] => [post_modified] => 2022-05-19 13:10:43 [post_modified_gmt] => 2022-05-19 05:10:43 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32943 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LIM, Steven [researchers_position] => Department of Chemical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Biomass.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0001-8699-9772 ) [researchers_info_2] => Array ( [researchers_name_2] => PANG, Yean Ling [researchers_position_2] => Department of Chemical Engineering, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Biomass2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0003-0060-3402 ) [original_article_reference] => [research_footprints] => Solid acid catalyst; Biodiesel; Oil palm empty fruit bunch; 4-benzenediazonium sulfonate; Palm fatty acid distillate [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study used biomass from oil palm empty fruit bunch (EFB) to produce a highly efficient solid acid catalyst for biodiesel production. Results proved that the activated carbon (AC) extracted from EFB, when sulfonated by 4-benzenediazonium sulfonate (4-BDS), provided the highest biodiesel yield when calcined at 200 oC. Under optimum esterification conditions of 7 hours and 20 wt.%, the proposed catalyst was able to churn out the highest biodiesel yield, 98.1%. Moreover, synthesizing such highly effective catalyst from low-cost biomass waste is an environmentally friendly solution. Potentially, the proposed technique would lower the production cost of biodiesel and, in the long run, reduce the energy cost in the country.

[the_background] =>

As fossil fuel reservoirs continue to deplete at an alarming rate, biodiesel is highly sorted after as an alternative energy source. Current biodiesel production is still relatively expensive compared to fossil fuels since existing biodiesel plants largely operate using ineffective catalysis technology with poor yield. To overcome these limitations, this study investigates the synthesis of a biomass-based heterogeneous acid catalyst. Ultimately, such an approach aims to be more cost-effective than the conventional methods and more environmentally friendly.

[the_sdg_impact] =>

In 2015, the bio-economy sector started to bloom with the production of second-generation biofuels finally achieving commercial scale. Following such progress, developing countries are faced with a new set of market opportunities and policy dilemmas to enhance their usage of biomass, which can be transformed into more valuable products. Coincidentally, in 2015, a set of 17 Sustainable Development Goals were announced by the United Nations addressing pressing issues of society, economy, and environment. The proposed biomass-based heterogeneous acid catalyst promises to expand existing low-efficient catalyst technology for supplying modern and sustainable energy services. At the same time, making the production of biodiesel more affordable with the environmentally friendly catalyst. (SDG 7: Affordable and clean energy)

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0304389419314864 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Biomass4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16038207_1652936978.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.jhazmat.2019.121532 [original_article_reference_fields] => Array ( [publication_title] => Biodiesel synthesis from oil palm empty fruit bunch biochar derived heterogeneous solid catalyst using 4-benzenediazonium sulfonate [journal_title] => Journal of Hazardous Materials [publisher] => Elsevier [year] => May 2020 [subject] => Chemical Engineering; Biomass; Biofuel ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [73] => WP_Post Object ( [ID] => 32923 [post_author] => 154 [post_date] => 2022-05-19 12:39:29 [post_date_gmt] => 2022-05-19 04:39:29 [post_content] => [post_title] => Highly Accurate New AI-based Cancer Prediction and Classification Framework [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => highly-accurate-new-ai-based-cancer-prediction-and-classification-framework [to_ping] => [pinged] => [post_modified] => 2022-05-19 12:39:29 [post_modified_gmt] => 2022-05-19 04:39:29 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32923 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SEAH, Choon Sen [researchers_position] => Faculty of Accountancy & Management, Department of International Business, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/prediction.png [researchers_profile] => https://www.researchgate.net/profile/Sean-Seah [researchers_second_profile] => "https://orcid.org/ 0000-0003-0328-7505" ) [researchers_info_2] => Array ( [researchers_name_2] => KASIM, Shahreen [researchers_position_2] => Faculty of Computer Science & Information Technology, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/prediction-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Shahreen-Kasim [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Cancer classification; Microarray; Significant directed walk; Gene expression [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study proposed a new computational framework for cancer prediction and classification called Significant Directed Walk (SDW). The framework was developed to refine the search direction and parameters in the existing directed random walk (DRW). This new genetic network allows the algorithm to study the nodes by comparing the gene expression value among the genes. Results showed that the SDW is able to perform better in terms of cancer prediction and classification sensitivity, with its accuracy reaching 95.03%. By adopting this proposed framework, the rate of early cancer detection can be improved significantly, in the long run, increasing the survival rate of the patients.

[the_background] =>

At present, the cancer prediction and classification tools are less accurate and sensitive and time-consuming as the screening process is not targeted. Moreover, the poor reference data pool limits the ability of the existing directed random walk (DRW) tool. Therefore, there is a demand for an improved DRW framework to identify more cancerous genes with higher accuracy in cancer classification of gene expression data. Hence, this study designs an improved and novel framework to identify the exact genes within the genome that might turn into cancer carriers through the gene expression value.

[the_sdg_impact] =>

According to WHO, cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020 alone. Early detection is among the most effective way to increase the survival rate of cancer patients. Thus, there is a dire need for technology upgrades and machine learning to shorten the time taken to screen for cancer markers, detection, and classification. This study addresses these needs and, upon implementation, would contribute to the long-term reduction of the premature mortality rate of cancer patients as envisioned in UN SDG 3: Good health and well-being.

[article_url] => https://link.springer.com/article/10.1007/s12652-020-02404-1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/prediction-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16037690_1652934950.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s12652-020-02404-1 [original_article_reference_fields] => Array ( [publication_title] => Significant directed walk framework to increase the accuracy of cancer classification using gene expression data [journal_title] => Journal of Ambient Intelligence and Humanized Computing [publisher] => Springer Nature [year] => August 2020 [subject] => Cancer; Artificial Intelligence (AI) ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [74] => WP_Post Object ( [ID] => 32903 [post_author] => 154 [post_date] => 2022-05-19 12:26:04 [post_date_gmt] => 2022-05-19 04:26:04 [post_content] => [post_title] => Factors Determining the Continuation of Virtual Teaching and Learning [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => factors-determining-the-continuation-of-virtual-teaching-and-learning [to_ping] => [pinged] => [post_modified] => 2022-05-19 12:26:04 [post_modified_gmt] => 2022-05-19 04:26:04 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32903 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MOSES, Priscilla [researchers_position] => Department of General Studies, Faculty of Creative Industries, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/teaching.png [researchers_profile] => https://www.researchgate.net/profile/Priscilla-Moses [researchers_second_profile] => https://orcid.org/0000-0002-4622-8903 ) [researchers_info_2] => Array ( [researchers_name_2] => YIM, Joanne [researchers_position_2] => Department of General Studies, Faculty of Creative Industries, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/teaching-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Joanne-Yim [researchers_second_profile_2] => https://orcid.org/0000-0003-0149-4260 ) [original_article_reference] => [research_footprints] => Continuance intention; Psychological ownership; Perceived ease of use; Perceived usefulness; Cloud-based virtual learning environment [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Theoretically, psychological ownership (PO) is essential to motivate users to adopt technology through their beliefs such as perceived usefulness and perceived ease of use. However, this study showed that the influences on teachers' continued reliance on technology might be more complex than that. Nevertheless, the results indicated that perceived ease of use (PEU) is a stronger reason for teachers to embrace cloud-based virtual learning environments than perceived usefulness (PU) despite teachers having gained experience using it and the platforms being user-friendly. Therefore, the education ministry and school authorities should consider catering to the teachers' readiness and need to encourage the use of cloud-based virtual technology in classrooms and learning widely.

[the_background] =>

Malaysia invested over 13 years with an estimated cost of RM1.5 billion (about US$500 million). The country is also recognized as one of the pioneers in Asia to initiate a nationwide cloud-based learning environment. However, literature proved that such technology is underutilized despite the strategies and policies designed to drive the adoption. Moreover, most past literature focused on the adoption behavior among students, university educators, or pre-service teachers. Little is known from the perspective of practicing school teachers. Hence, this study examines the factors driving teachers to develop psychological ownership towards a cloud-based virtual learning environment and their intention to continue. The outcome intends to understand the underutilization of such technology in education for developing countries facing similar challenges.

[the_sdg_impact] =>

Education is among one of the significantly affected sectors amidst this COVID-19 pandemic. Teaching and learning experiences had to instantly adopt and adapt to virtual learning environment leaving students and teachers to struggle, especially in developing and under-developed countries. Apart from the readiness in terms of infrastructure, the willingness of teachers to utilize these facilities and continue using them even after physical classes resume needs to be understood. Therefore, the insights provided by this study would benefit policymakers and school authorities to re-evaluate teachers' training needs to embrace a virtual learning environment to provide the best 21st century learning experience for students. (SDG 4: Quality education)

[article_url] => https://link.springer.com/article/10.1007/s11423-019-09661-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/teaching-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16037471_1652934106.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s11423-019-09661-8 [original_article_reference_fields] => Array ( [publication_title] => Predicting teachers’ continuance in a virtual learning environment with psychological ownership and the TAM: a perspective from Malaysia [journal_title] => Educational Technology Research and Development [publisher] => Springer Nature [year] => April 2019 [subject] => General Studies; Virtual Learning ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [75] => WP_Post Object ( [ID] => 32883 [post_author] => 154 [post_date] => 2022-05-19 12:13:24 [post_date_gmt] => 2022-05-19 04:13:24 [post_content] => [post_title] => Oil Palm Waste-derived Nano-photocatalyst Can Treat Wastewater from Textile Industry [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => oil-palm-waste-derived-nano-photocatalyst-can-treat-wastewater-from-textile-industry [to_ping] => [pinged] => [post_modified] => 2022-05-19 12:13:24 [post_modified_gmt] => 2022-05-19 04:13:24 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32883 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NG, Law Yong [researchers_position] => Department of Chemical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Oil.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-6868-4977 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Agricultural waste; Carbon quantum dot; Hydrothermal; Photocatalytic degradation; Organic dye [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S2214714420306930-ga1.jpg [figures] => [video] => [the_novelty] =>

Lignin extracted from empty fruit bunches (EFB) can undergo hydrothermal treatment with urea to produce a stable photocatalyst that degrades dye molecules. The study used this technique to develop photocatalysts, nitrogen-doped carbon quantum dots (NCQDs), to treat water sources polluted with harmful organic dyes. By including NCQDs, 97%-98% of methylene blue and malachite green dyes were degraded within 120-180 minutes of sunlight exposure compared to only 59% of degradation without the catalyst. Furthermore, findings also showed that the number of cycles to repeatedly used photocatalyst could go up to 15 cycles with approximately 70% decolorization efficiency. In conclusion, the proposed NCQDs are not just effective water treatment substances but are also a greener option to reduce oil palm waste.

[the_background] =>

Synthetic organic dyes used in textile industries are major sources of water pollution. Dyes such as methylene blue and malachite green are highly toxic and harmful for marine life and humans. Moreover, the presence of dye molecules in the water stream may prevent sunlight penetration into the water, affecting the photosynthesis of aquatic plants. Therefore, a stable and reliable catalyst is required to treat the wastewater before discharging. Separately, empty fruit bunch (EFB) are oil palm waste that is largely discarded. The rich molecular make-up of this waste has a huge potential to be converted into carbon-based nanoparticles and catalysts. Thus, this study proposed nano-photocatalyst derived from biomass as a safe solution to decolorize the dye molecules in the water streams.

[the_sdg_impact] =>

A 2020 article published by CNN highlighted devastating environmental and health effects caused by textile dyeing practices of the global fashion industry. Nations like Bangladesh, highly dependent on the garment sector as their source of income, face severe pollution threats as the industry’s wastewater largely gets dumped directly into their rivers and streams. Therefore, this study is useful to substantially reduce such water pollution threats and minimize their adverse impacts on human health and the environment through an environmentally sound management technique. (SDG 12: Responsible consumption and production)

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S2214714420306930?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Oil-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16037325_1652933363.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.jwpe.2020.101816 [original_article_reference_fields] => Array ( [publication_title] => Sustainable production of nitrogen-doped carbon quantum dots for photocatalytic degradation of methylene blue and malachite green [journal_title] => Journal of Water Process Engineering [publisher] => Elsevier [year] => April 2021 [subject] => Chemical Engineering; Water Process Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [76] => WP_Post Object ( [ID] => 32863 [post_author] => 154 [post_date] => 2022-05-19 11:48:58 [post_date_gmt] => 2022-05-19 03:48:58 [post_content] => [post_title] => Hypertension Patients on Medication Should Avoid Consuming Green Tea Excessively [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => hypertension-patients-on-medication-should-avoid-consuming-green-tea-excessively [to_ping] => [pinged] => [post_modified] => 2022-05-24 09:40:40 [post_modified_gmt] => 2022-05-24 01:40:40 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32863 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LEE, Siew Keah [researchers_position] => Faculty of Medicine and Health Sciences, Department of Pre-clinical sciences, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/hypertension.png [researchers_profile] => [researchers_second_profile] => 0000-0002-4920-2821 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => EGCG; Catechin; Green Tea; Nadolol; Herb-drug interaction; Hypertension [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S0944711321001665-ga1_lrg.jpg [figures] => [video] => [the_novelty] =>

This study provides evidence of the counter-effect of a common botanical product when consumed by hypertension patients on medication. One of the major catechins found in green tea extract is known as epigallocatechin gallate (EGCG). Due to the established blood pressure lowering effects of green tea, it is not surprising that hypertension patients might consume highly concentrated or purified EGCG along with their medication with or without their physicians’ knowledge. However, based on a 14-day observation of continuous consumption of herbal supplement with EGCG content as low as 10 mg/kg b.w. showed that EGCG interfered with the effectiveness of nadolol, an antihypertensive drug commonly prescribed to hypertensive patients. Such reduced drug effect results from RNA expression dysregulation of the key nadolol transporters (Oatp 1a5, Oct1and P-gp). Thus, proving an unfavorable herb-drug interaction and outcome among the hypertension patients prescribed nadolol. Essentially, these insights are useful for physicians to advise their patients, adjust nadolol prescription dosage, or prescribe alternative drugs for green tea consumers with hypertension.

[the_background] =>

Statistics showed that less than 13% of hypertensive patients achieved blood pressure control (<140/90 mm Hg) while on treatment. Such a scenario results in physicians either prescribing more medication or increasing the dosage. In the long run, these actions would potentially contribute to medication and economic burden as well as increase the risk of drug side effects among the consumers. Meanwhile, herbal or ‘natural’ medicine has been gaining popularity among patients with various ailments. Particularly, green tea consumption is highly favored due to its extensive therapeutic effects. Although one of its medicinal properties is to lower blood pressure, its effect on hypertension patients on antihypertension medication is unclear. Therefore, this study investigates the effects of a widely available herbal supplement, EGCG, on the blood pressure of those given nadolol and the biological mechanisms involved.

[the_sdg_impact] =>

According to WHO, close to 1.3 billion adults aged 30-79 years worldwide have hypertension, and it is a major cause of premature death. Adopting a healthy lifestyle is among the most recommended hypertension management techniques, while many patients trust herbs or ‘natural’ medicine to do the trick. Therefore, it is crucial for physicians and healthcare personnel to advise patients on medication to monitor the supplements or herbs that are not prescribed yet being consumed. In extension, such effort would improve the drug effectiveness among hypertension patients on medication and, in extension, reduce premature mortality of hypertension-related cardiovascular diseases (SDG 3: Good health and well-being).

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0944711321001665 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/hypertension-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16036980_1652931908.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.phymed.2021.153623 [original_article_reference_fields] => Array ( [publication_title] => Oral epigallocatechin gallate reduces intestinal nadolol absorption via modulation of Oatp1a5 and Oct1 transcriptional levels in spontaneously hypertensive rats [journal_title] => Phytomedicine [publisher] => Elsevier [year] => September 2021 [subject] => Medicine and Health Sciences; Pre-clinical sciences ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [77] => WP_Post Object ( [ID] => 32846 [post_author] => 154 [post_date] => 2022-05-19 11:32:01 [post_date_gmt] => 2022-05-19 03:32:01 [post_content] => [post_title] => Non-destructive Test for Quick Concrete Strength Test [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => non-destructive-test-for-quick-concrete-strength-test [to_ping] => [pinged] => [post_modified] => 2022-05-19 11:32:01 [post_modified_gmt] => 2022-05-19 03:32:01 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32846 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LEE, Foo Wei [researchers_position] => Department of Civil Engineering (DCI), Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/ ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => compressive strength; non-destructive test (NDT); elastic wave; air-entrained rubberized concrete [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/crystals-10-00912-ag-550.webp [figures] => [video] => [the_novelty] =>

This study suggested adopting the non-destructive test (NDT) as a more effective method to assess concrete strength during the hardening process. Among the significant improvement observed by adopting this testing method is the amount of time needed. Results indicate that the test is able to reduce the time taken to 1 day, as compared to the conventional process, which requires 28 days. Moreover, this approach is also resource-efficient as it does not involve the specimen being demolished during testing. Last but not least, the findings proved that wave amplitude and velocity are crucial to determining the compressive strength development of air-entrained rubberized concrete.

[the_background] =>

In recent years, there has been a steadily increasing demand for rubberized concrete due to its lightweight, strength, elasticity, ductility, and energy and force absorption potentials. Air-entraining agents have been introduced in rubberized concrete to further lengthen its lifespan and durability. However, there has been inconsistency in terms of the compressive strength of air-entrained rubberized concrete compared to conventional concrete. The test required to determine the compressive strength and properties is known to be tedious and time-consuming. Therefore, this study proposes a more efficient and reliable assessment of rubberized concrete specimens, particularly in completed buildings.

[the_sdg_impact] =>

Over the years, green construction has been receiving more attention. Concrete production is slowly being altered to be greener through the use of scrap tires to produce rubberized concrete. To ensure the shift to an environmentally sound material does not compromise the safety and durability of the buildings constructed, a reliable testing method is necessary. Hence, the findings of this study would serve as a reference to enhance and upgrade the technological capabilities of the construction industry. (SDG 9: Industry, innovation and infrastructure)

[article_url] => https://www.mdpi.com/2073-4352/10/10/912 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/concrete-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16036703_1652930795.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.3390/cryst10100912 [original_article_reference_fields] => Array ( [publication_title] => Compressive Strength Forecasting of Air-Entrained Rubberized Concrete during the Hardening Process Utilizing Elastic Wave Method [journal_title] => Crystals [publisher] => MDPI [year] => October 2020 [subject] => Civil Engineering; ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [78] => WP_Post Object ( [ID] => 32829 [post_author] => 154 [post_date] => 2022-05-19 11:20:47 [post_date_gmt] => 2022-05-19 03:20:47 [post_content] => [post_title] => Smartphone App Smart Enough to Detect Skin Cancer [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => smartphone-app-smart-enough-to-detect-skin-cancer [to_ping] => [pinged] => [post_modified] => 2022-05-19 11:20:47 [post_modified_gmt] => 2022-05-19 03:20:47 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32829 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUM, Yan Chai [researchers_position] => Department of Mechatronics and Biomedical Engineering (DMBE), Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Smartphone.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-9657-8311 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Melanoma; Skin cancer screening; Skin lesion detection; Multimedia-based healthcare systems; ;Smartphone app; ;Teledermatology; Deep learning; ISIC skin lesions dataset [graphic_abstract] => [figures] => [video] => [the_novelty] =>

The study proposed using deep learning technology to design a highly accurate skin cancer diagnosis tool in the form of a smartphone app. In order to optimize the functions of the app, a thorough analysis was performed using different computational intelligence models on various models of smartphones, screen resolutions, and android versions. As a whole, the proposed technology is set to design a cheap, user-friendly, and reliable smartphone camera-based app capable of eliminating the need for sophisticated external sensor tools. Through such an app, the chances of early skin cancer detection can be improved, and physicians' inconsistent manual diagnosis could be avoided.

[the_background] =>

One of the most effective ways to battle cancer is through early detection. At present, early detection of skin cancer is highly reliant on experts such as doctors and dermatologists. However, past literature has proven that the conventional method such as manual inspection using ABCDE criteria has various limitations, namely subjectivity and inaccuracy, owing to the varying experience level of dermatologists and irregular characteristics of malignant skin lesions. Thus, leading to the condition being missed or misdiagnosed. Therefore, this study aims to replace the current skin cancer early detection method with object detection and deep learning technology by integrating the ABCDE criteria. Since smartphones or smart devices have seamlessly been integrated into our daily routine, this study proposes the development of a smartphone app as a potential early diagnostic tool.

[the_sdg_impact] =>

According to the World Health Organisation (WHO), there has been a significant rise in the cases of malignant skin cancer over the past decade. Early detection of skin cancer is required to classify symptoms so that attending dermatologists and clinicians can recommend effective disease control measures. Presently, the computational capability of smart handheld devices is feasible to be integrated with object detection technology. As a result, the coupling of smartphones and deep learning could aid in detecting and classifying skin lesions. A handy diagnostic tool with such capability would increase the chances of early detection, thus improving the survival rates of the patients by having the disease treated sooner. (SDG 3: Good health and well-being)

[article_url] => https://link.springer.com/article/10.1007/s11042-021-11013-9 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Smartphone-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16036539_1652930192.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s11042-021-11013-9 [original_article_reference_fields] => Array ( [publication_title] => The development of skin lesion detection application in smart handheld devices using deep neural networks [journal_title] => Multimedia Tools and Applications [publisher] => Springer Nature [year] => May 2021 [subject] => Mechatronics and Biomedical Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [79] => WP_Post Object ( [ID] => 32812 [post_author] => 154 [post_date] => 2022-05-19 11:09:08 [post_date_gmt] => 2022-05-19 03:09:08 [post_content] => [post_title] => Psychological Factors Could Trigger Obesity among Adults [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => psychological-factors-could-trigger-obesity-among-adults [to_ping] => [pinged] => [post_modified] => 2022-05-24 09:42:25 [post_modified_gmt] => 2022-05-24 01:42:25 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32812 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => FOO, Chai Nien [researchers_position] => Department of Population Medicine, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/obesity.png [researchers_profile] => [researchers_second_profile] => "https://orcid.org/ 0000-0003-0362-6394" ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => obesity; risk factors; psychological; adults; Malaysia [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study provided evidence of potential psychological determinants that cause obesity among men and women. Consistent with past literature, the results proved that women are more likely to be obese than men. More specifically, married, middle-aged Indian women with only school-level education face a higher risk of being obese. Among the contributing psychological factors in women for such an outcome is the stressful life events encountered and their quality of life. On the other hand, men facing perceived stress or having suicidal ideation have higher chances of being obese. To the authors’ knowledge, this study provides primary evidence of the association between psychological determinants and adult obesity. Potentially, policymakers could use the findings as a reference to address psychological needs when designing effective obesity prevention strategies in the community.

[the_background] =>

Obesity has been commonly linked to the risk of developing various major illnesses and psychological effects. However, the understanding of how psychological factors could lead to obesity remains unclear. In Malaysia, obesity prevalence among adults has shown a four-fold increase between 1996 and 2015. Being highly populated with working adults, the high incidence rate of obesity in Selangor is concerning as compared to other states. Therefore, this study aims to understand the underlying factors and psychological determinants causing adults of Selangor to be obese or overweight.

[the_sdg_impact] =>

According to Global Burden of Disease 2019, a high body mass index is among the top risk factors contributing to the development of non-communicable diseases (NCDs). In the global status report on NCDs, WHO recorded 39% of adults to be overweight, and the prevalence is expected to rise by 2025. In the Malaysian context, it recorded the highest obesity rate in adults compared to other Southeast Asian countries. Therefore, the findings of this study would benefit policymakers and healthcare personnel to understand the socio-demographic variables and psychological factors leading to poor health conditions among Malaysians. Such insights would contribute to effective prevention and treatment strategies when managing obesity-linked NCDs (SDG: Good health and well-being).

[article_url] => https://www.mdpi.com/1660-4601/18/3/868 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/obesity3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16036316_1652929474.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.3390/ijerph18030868 [original_article_reference_fields] => Array ( [publication_title] => Prevalence, Associated Factors and Psychological Determinants of Obesity among Adults in Selangor, Malaysia [journal_title] => International Journal of Environmental Research and Public Health [publisher] => MDPI [year] => January 2021 [subject] => Medicine, Health Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [80] => WP_Post Object ( [ID] => 32791 [post_author] => 154 [post_date] => 2022-05-19 10:57:29 [post_date_gmt] => 2022-05-19 02:57:29 [post_content] => [post_title] => Organic Liquid-based Air Pressure Sensor with Dual Functions [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => organic-liquid-based-air-pressure-sensor-with-dual-functions [to_ping] => [pinged] => [post_modified] => 2022-05-19 10:57:29 [post_modified_gmt] => 2022-05-19 02:57:29 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32791 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHEE, Pei Song [researchers_position] => Department of Mechatronics and Biomedical Engineering (DMBE), Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/utar01.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0001-7165-7788 ) [researchers_info_2] => Array ( [researchers_name_2] => LIM, Eng Hock [researchers_position_2] => Department of Electrical and Electronic Engineering, Universiti Tunku Abdul Rahman (UTAR), Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/wireless4.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0001-5301-1115 ) [original_article_reference] => [research_footprints] => Electrical and electronic engineering; Fluids; Polymers [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Unlike existing sensors that are limited to only detecting air pressure, this study designed a novel structure that combines the antenna and pressure sensing functionalities into a single piece. The proposed liquid dielectric resonator antenna (LDRA) can achieve high compactness as it uses an organic solvent, acetonitrintrile, with a low loss tangent at 2.4 GHz. Findings indicate that the antenna gain of the design is at least 2 dB higher than that of the commonly suggested water LDRA. Additionally, the soft-lithography technique used allows rapid prototyping. In short, this proposed design promises a dual-sensing functionality with improved sensitivity and circuit footprint. It also reduces material costs and can potentially be expanded into wearable devices that require higher power consumption.

[the_background] =>

Pressure sensors are essential for monitoring and controlling, particularly in biomedical technologies and auto industries. One of the limitations of presently available commercial sensors is the restricted mobility as they require wires and batteries to operate. Moreover, the existing rigid containers also limit the functions of the antenna structure as a pressure sensor. Hence, requiring a more flexible and stretchable material to improve the storage of electrical energy that can respond to the change of stimuli. As a solution, this study proposed a wireless power technology that combines both wireless receivers and sensors as an alternative.

[the_sdg_impact] =>

Pressure sensors play a huge role in the medical and healthcare sectors, especially among ventilator and respiratory manufacturers. Over the decade, there has been a noticeable need for flexible pressure sensors, preferably low-cost, portable, and light-weighted. Besides, the 9th UN SDG, Industry, Innovation and Infrastructure, also encourages the development of quality, reliable, sustainable, and resilient infrastructure to support the evolving community and technological needs. Hence, in alignment with such goals, the materials and design of the liquid dielectric resonator antenna (LDRA) proposed promises to improve the air pressure sensing capability by overcoming the limitations of existing models.

[article_url] => https://www.nature.com/articles/s41598-020-72021-7 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/wireless.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16036120_1652928647.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41598-020-72021-7 [original_article_reference_fields] => Array ( [publication_title] => Compact organic liquid dielectric resonator antenna for air pressure sensing using soft material [journal_title] => Scientific Reports [publisher] => Springer Nature [year] => September 2020 [subject] => Electrical and Electronic Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [81] => WP_Post Object ( [ID] => 31376 [post_author] => 154 [post_date] => 2022-04-14 11:06:33 [post_date_gmt] => 2022-04-14 03:06:33 [post_content] => [post_title] => Superheavy Nuclei 119 − 122 Synthesis in Fusion-Evaporation Reactions [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => superheavy-nuclei-119-%e2%88%92-122-synthesis-in-fusion-evaporation-reactions [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:42:25 [post_modified_gmt] => 2022-08-09 02:42:25 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31376 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => FENG, Zhaoqing [researchers_position] => School of Physics, South China University of Technology, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/02/NST-19-author2-.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Dinuclear system model; Fusion-evaporation reactions; Superheavy nuclei; Cross sections [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/04/NST_Article-19_V3_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

While attempting to produce superheavy nuclei (SHN) with Z = 119 – 122 in the fusion-evaporation reactions within the dinuclear system (DNS) model, this study discovered that 44Sc+252Es was the optimal combination in the 3n channel with a cross-section of 3 pb. Maximum cross-sections of the evaporation residues (ER) were found in the (2-5)n evaporation channels, i.e., approximately 1 pb in the 3n evaporation channel. The results were in good agreement with the experimental data from Dubna. The SHN were produced by bombarding the actinide nuclides with the transition elements from Period 4. Since the orientations were the main determining factor of the ER cross-sections, all possible collision orientations were included by applying the Monte Carlo approach in the nucleon transfer process. Using these results as a reference, future investigations should be conducted to uncover other potentially promising reaction mechanisms to produce SHN.

[the_background] =>

SHN (Z ≥ 106) are given rise by the strong binding shell effect when the Coulomb repulsion is overcome. The initial synthesis of SHN nearly half a decade ago involved multinucleon transfer reactions in collisions of two actinide nuclei. Meanwhile, the formation dynamics of SHN in massive fusion and multinucleon transfer reactions have been the main focus. Hence, systematic studies on the production of SHN are needed to predict the reaction mechanism, including optimal projectile-target combinations. This study conducted a comprehensive study on the fusion dynamics of the formation of superheavy nuclei within the DNS model by adopting the Monte Carlo approach. The findings shed some light on the fusion-evaporation reactions applied for synthesizing SHN with Z = 119 – 122, bringing SHN research one step closer to discovering “island of stability.”

[the_sdg_impact] =>

Superheavy elements (SHE) are rare naturally and only exist briefly under highly controlled circumstances. Their common applications include smoke detectors (americium), neutron radiography and neutron interrogation (curium and californium), and nuclear weapons (plutonium). Thus, besides exploring the concept of “magic numbers” and “island of stability,” a better understanding of the formation mechanism of SHE could lead to a significant advancement of nuclear technology. By focusing on the synthesis of various SHN via fusion-evaporations reactions, the output of this in-depth study contributed to the progress of SHN synthesis. Therefore, it fulfilled UNSDG9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00946-3 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/12/Superheavy-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/12/NST-19_11984717_1639560545.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00946-3 [original_article_reference_fields] => Array ( [publication_title] => Systematics on production of superheavy nuclei Z=119−122 in fusion-evaporation reactions [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => September 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Biu1D3sKr8c [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/04/NST-19-with-Chinese-Sub.mp4_snapshot_00.01_2022.06.14_10.49.15.jpg ) ) [82] => WP_Post Object ( [ID] => 32529 [post_author] => 154 [post_date] => 2022-03-22 11:44:32 [post_date_gmt] => 2022-03-22 03:44:32 [post_content] => [post_title] => Exploration of Short-Lived Nuclei Using Newly Commissioned Collinear Laser Spectroscopy [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => exploration-of-short-lived-nuclei-using-newly-commissioned-collinear-laser-spectroscopy [to_ping] => [pinged] => [post_modified] => 2023-12-26 10:10:36 [post_modified_gmt] => 2023-12-26 02:10:36 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32529 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => BAI, Shiwei (白世伟) [researchers_position] => School of Physics, State Key Laboratory of Nuclear Physics & Technology, Peking University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/03/Commissioning-.png [researchers_profile] => https://www.researchgate.net/profile/Shiwei-Bai [researchers_second_profile] => https://orcid.org/0000-0002-6087-9788 ) [researchers_info_2] => Array ( [researchers_name_2] => YANG, Xiaofei (杨晓菲) [researchers_position_2] => School of Physics, State Key Laboratory of Nuclear Physics & Technology, Peking University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/03/Commissioning-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Xiaofei-Yang-13 [researchers_second_profile_2] => https://orcid.org/my-orcid?orcid=0000-0002-1633-4000 ) [original_article_reference] => [research_footprints] => Nuclear properties; Collinear laser spectroscopy; Laser-ablation ion source; Photon detection; Isotope shift [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/03/2022_NST_Article_02_v2_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

As an initial step to fully leverage the available radioactive ion beam facilities and resources, this study developed a collinear laser spectroscopy (CLS) apparatus combined with an offline laser ablation ion source at Peking University. The CLS was commissioned using a bunched stable calcium ion beam being accelerated up to 20 keV, with a pulse width of approximately 10 µs. This CLS, integrated with the ion source and an anti-collinear laser system, has enabled high-resolution measurements of the hyperfine structure spectra of stable 40,42,44,48Ca isotopes. With its successful commissioning, the CLS is ready for laser spectroscopy measurement of unstable nuclei at radioactive ion beam (RIB) facilities in China, paving the way for further developing higher-sensitivity collinear resonance ionization spectroscopy techniques.

[the_background] =>

The fundamental properties of atomic nuclei, such as nuclear spins, magnetic dipole moments, electric quadrupole moments, and mean-squared charge radii, are the essential experimental observables in studying the exotic nuclear structure and nucleon-nucleon interactions. Despite having various experimental methods to measure these nuclear properties, CLS is one of the most sophisticated experimental techniques available to simultaneously measure these properties in a nuclear-model independent way. This is realized by probing the subtle hyperfine effects, only as small as one part in a million compared with the total atomic transition frequency, resulting from the interaction between the atomic nucleus and surrounding electrons. CLS system has been set up in various RIB facilities worldwide to explore the exotic structure of radioactive isotopes. Lanzhou's HIRFL-RIBLL and Beijing's BRIF are among the uprising RIB facilities with short-lived isotopes ready for in-depth nuclear structure studies. The CLS, however, has not yet been involved in nuclear physics research at the domestic RIB facilities so far. The CLS apparatus developed by this study thus represents new opportunities for advanced studies of the nuclear properties of unstable nuclei at the RIB facilities in China.

[the_sdg_impact] =>

The unexpected new phenomena of unstable nuclei have been continuously unveiled when the study reaches the exotic isotopes far from the beta-stability line. By exploring short-lived nuclei produced artificially at RIB facilities, this study helps scientists understand the rich, complex, and even unexplored exotic structure of atomic nuclei and the nucleon-nucleon interactions. Ultimately, this would unveil the puzzle: where and how heavy matter forms in the universe (UNSDG 9: Industry, Innovation & Infrastructure).

[article_url] => https://link.springer.com/article/10.1007/s41365-022-00992-5 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/03/Commissioning-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/03/NST02_14519379_1647920136.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-022-00992-5 [original_article_reference_fields] => Array ( [publication_title] => Commissioning of a high-resolution collinear laser spectroscopy apparatus with a laser ablation ion source [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => January 2022 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/T_zZ0EyOqCs [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/03/NST22-02-with-Chinese-Sub.mp4_snapshot_00.01_2022.06.14_10.56.31.jpg ) ) [83] => WP_Post Object ( [ID] => 32278 [post_author] => 154 [post_date] => 2022-03-13 12:52:32 [post_date_gmt] => 2022-03-13 04:52:32 [post_content] => [post_title] => Mature Software for 3D Bunch Position & Charge Measurement [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => mature-software-for-3d-bunch-position-charge-measurement [to_ping] => [pinged] => [post_modified] => 2023-12-26 10:08:56 [post_modified_gmt] => 2023-12-26 02:08:56 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32278 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => XU, Xingyi Xu (许兴懿) [researchers_position] => Beam Instrument and Control Department, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/03/HOTCAP.png [researchers_profile] => https://www.researchgate.net/profile/Xingyi-Xu [researchers_second_profile] => https://orcid.org/0000-0001-6665-7302 ) [researchers_info_2] => Array ( [researchers_name_2] => LENG, Yongbin Leng (冷用斌Y) [researchers_position_2] => Beam Instrument and Control Department, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/03/HOTCAP2.png [researchers_profile_2] => https://www.researchgate.net/profile/Yongbin-Leng [researchers_second_profile_2] => https://orcid.org/0000-0003-4170-4998 ) [original_article_reference] => [research_footprints] => Bunch-by-bunch measurement; HOTCAP software package; Data analysis; High-speed oscilloscope [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/03/2022_NST_Article_01_v2_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

This study developed HOTCAP, a free, user-friendly, and interactive software, for simultaneous measurement of 3D bunch-by-bunch position and charge from the waveform of a high-speed oscilloscope. Being able to operate on Windows 10, HOTCAP could also output injection transient analysis, bunch response function reconstruction, and turn-by-turn beam analysis. Its visual interface was developed based on PyQT5. HOTCAP was coded using Python on the backend, and its architecture comprised the user interface (UI) module, the calculation module, and the input-output (IO) module. Future studies shall improve the algorithm to eliminate HOTCAP’s current need for a constant bunch length.

[the_background] =>

Bunch-by-bunch measurement includes transverse position measurements, longitudinal phase measurements, charge measurements, beam size measurements, and emittance. Among these, position measurement is the most important and common technique carried out via the random phase sampling method using a digital oscilloscope. However, since a large amount of input data and complex digital signal processing are involved, there is a high demand for comprehensive data processing algorithms or corresponding data processing software packages to be used in high-speed oscilloscope-based 3D bunch charge and position measurements. In order to fulfill the need, researchers from Shanghai Synchrotron Radiation Facility (SSRF) Beam Instrument Group have successfully developed HOTCAP (a visualization software package) to serve as an online measurement system that can simultaneously measure the bunch-by-bunch 3D position and strip the refilled charge signal. Other accelerators will benefit from this software as soon as the researchers share the source code in the near future.

[the_sdg_impact] =>

SSRF strives to uphold its potential and reputation as a world-class state-of-the-art beam facility. To help achieve that, this research developed the first mature and free software package for high-speed oscilloscope-based three-dimensional (3D) bunch charge and position measurement. The output contributes to the advancement of beam diagnosis technology, which enhances the operation of synchrotron radiation facilities, realizing UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00966-z?utm_source=xmol&utm_medium=affiliate&utm_content=meta&utm_campaign=DDCN_1_GL01_metadata [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/03/HOTCAP4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/03/NST01_14284976_1647146778.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00966-z [original_article_reference_fields] => Array ( [publication_title] => HOTCAP: a new software package for high-speed oscilloscope-based three-dimensional bunch charge and position measurement [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => November 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/lac7N_Urqrs [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/03/NST22-01-with-Chinese-Sub.mp4_snapshot_00.02_2022.06.14_10.54.33.jpg ) ) [84] => WP_Post Object ( [ID] => 31053 [post_author] => 154 [post_date] => 2022-03-13 12:31:17 [post_date_gmt] => 2022-03-13 04:31:17 [post_content] => [post_title] => Enhanced GRID Mission Nanosatellite Gamma-Ray Detector [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => enhanced-grid-mission-nanosatellite-gamma-ray-detector [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:32:40 [post_modified_gmt] => 2022-08-09 02:32:40 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31053 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WEN, Jiaxing (温家星 ) [researchers_position] => Engineering Physics, Tsinghua University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/Wen-Jiaxing.png [researchers_profile] => https://www.researchgate.net/profile/Jiaxing-Wen [researchers_second_profile] => https://orcid.org/0000-0003-4328-0172 ) [researchers_info_2] => Array ( [researchers_name_2] => ZENG, Ming (曾鸣) [researchers_position_2] => Engineering Physics, Tsinghua University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/11/Zeng-Ming.png [researchers_profile_2] => https://www.researchgate.net/profile/Ming-Zeng-4 [researchers_second_profile_2] => https://orcid.org/0000-0001-9717-1751 ) [original_article_reference] => [research_footprints] => Gamma-ray bursts; Scintillation detectors; SiPM; CubeSat [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/03/56.jpg [figures] => [video] => [the_novelty] =>

This research revealed the in-depth design (both hardware and firmware) of the first and second compact nanosatellite gamma-ray detectors built for the Gamma-Ray Integrated Detectors (GRID) mission. The detector comprised four Gd2Al2Ga3O12 : Ce (GAGG:Ce) scintillators coupled with four silicon photomultiplier (SiPM) arrays, and the detector’s gamma-ray detection efficiency ranged between 10 keV and 2 MeV. The first and second detectors were launched into Sun-synchronous orbits with an altitude and inclination of 500 km 97.5 ° and 97.3 °, on October 29, 2018, and November 6, 2020, respectively. The detectors managed to accumulate data for more than 300 hours of on-orbit observation. For further context, detailed calibration of the detector using both simulations and experiments will be reported elsewhere in the near future.

[the_background] =>

The GRID mission is a project which bears the main objective to involve students in monitoring the transient gamma-ray sky in the local universe and in accumulating a sample of gamma-ray bursts (GRBs) associated with gravitational waves (GWs). The first detector was launched into a Sun-synchronous orbit on October 29, 2018. After the on-orbit functional and performance tests of the first detector, fewer hardware modifications and improvements have been made in the second detector. This paper shows the detailed design of the GRID detector, and the functionality and performance of this design have been verified by two launches. By sharing these significant details of the compact CubeSat gamma-ray detector, this study encourages and attracts students from multi-disciplinary to participate in GRID so as to grow their hands-on experience in astrophysics.

[the_sdg_impact] =>

Astrophysics is a subject area that often involves multi-disciplinary collaboration in developing hardware and data. Hence, having a well-developed research facility and infrastructure is essential to let students and researchers deploy their output in a real environment. Besides sharing the detailed hardware and firmware design, this study also motivates students to participate in the GRID mission by describing how the latter empowered the study's progress. Therefore, the outcome of this study aligns well with UNSDG 9: Industry, Innovation & Infrastructure by supporting the development of research and technology.

[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00937-4 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/Nanosatellite-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST-Article-17-audio_11153697_1636605199.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00937-4 [original_article_reference_fields] => Array ( [publication_title] => Compact CubeSat Gamma-ray detector for GRID mission [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => September 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/sg8Xg20E_w0 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/03/NST-17-with-Chinese-Sub.mp4_snapshot_00.01_2022.04.14_11.41.57.jpg ) ) [85] => WP_Post Object ( [ID] => 32082 [post_author] => 154 [post_date] => 2022-03-09 14:42:04 [post_date_gmt] => 2022-03-09 06:42:04 [post_content] => [post_title] => New Multifunctional Carbon Nanosheet Construction Strategy [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => new-multifunctional-carbon-nanosheet-construction-strategy [to_ping] => [pinged] => [post_modified] => 2023-11-21 13:43:21 [post_modified_gmt] => 2023-11-21 05:43:21 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=32082 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WU, Dingcai [researchers_position] => School of Chemistry, Sun Yat-sen University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/03/carbon.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Carbon nanosheets; Multifunctional templates; Hierarchical pores; Heteroatom doping [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/03/2022_CPP_Article_01_v2_EN-scaled.jpg [figures] => [video] => [the_novelty] =>

This study explores a range of construction mechanisms with different conditions to improve present 2D material performance. As a breakthrough, a new strategy to construct Fe,N-codoped hierarchical porous carbon nanosheets (Fe-N-HP-CNS) by using 2D Fe-Zn layered double hydroxides (Fe-Zn-LDH) was developed. The proposed multifunctional templating strategy simplifies the synthetic route and yields well-defined 2D carbon nanosheets with a hierarchical porous structure and a functional carbon framework. Overall, the novel method promises an improved template functionality while eliminating the adverse effects and limitations of single-functioned conventional carbon nanosheet construction techniques.

[the_background] =>

2D porous carbon nanosheets have desirable physical and chemical properties, including excellent electrical conductivity, superior chemical stability, and adjustable carbon framework. Hence, the materials have been widely used in electrochemical energy storage, catalysis, battery, water treatment, and many more. With that said, existing carbon nanosheet templates largely fit a single function. Moreover, the preparation processes are not only costly and complex, but also non-environmentally friendly. Therefore, this study looks into the synthesis process of carbon nanosheets by leveraging the 2D structure and potential multifunctional characteristics.

[the_sdg_impact] =>

2D porous carbon nanosheets have become the recent most in-demand porous carbon due to the uniqueness of its structure and promising functionalities, potentially useful in various applications. Given the increasing requirements on applications in our current lifestyle, there’s a growing need for a simple and precise construction strategy of this ‘super’ material. Therefore, the novel approach developed in this study expands the functionality of 2D porous carbon nanosheets by improving resource-use efficiency and adopting a cleaner and greener construction mechanism (SDG 9: Industry, Innovation and Infrastructure).

[article_url] => https://link.springer.com/article/10.1007/s10118-022-2656-x [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/03/carbon-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/03/CPP1_14184756_1646807984.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s10118-022-2656-x [original_article_reference_fields] => Array ( [publication_title] => Multifunctional Templating Strategy for Fabrication of Fe, N-Codoped Hierarchical Porous Carbon Nanosheets [journal_title] => Chinese Journal of Polymer Science [publisher] => Springer Nature [year] => November 2021 [subject] => Chemistry, Polymer Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/XBJI6IxOVQ0 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/03/CPP-with-Chinese-Sub1.mp4_snapshot_00.01_2022.04.28_10.07.19.jpg ) ) [86] => WP_Post Object ( [ID] => 31390 [post_author] => 154 [post_date] => 2022-02-26 11:06:40 [post_date_gmt] => 2022-02-26 03:06:40 [post_content] => [post_title] => New Variance Reduction Method for Higher Accuracy Monte Carlo (MC) Reactor Criticality Calculation [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => new-variance-reduction-method-for-higher-accuracy-monte-carlo-mc-reactor-criticality-calculation [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:45:39 [post_modified_gmt] => 2022-08-09 02:45:39 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31390 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PAN, Qingquan (潘清泉) [researchers_position] => School of Nuclear Science and Engineering, Shanghai Jiao Tong University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/12/NST20.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => LIU, Xiaojing (刘晓晶) [researchers_position_2] => School of Nuclear Science and Engineering, Shanghai Jiao Tong University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => RMC code; Global homogenization; Variance reduction; SPN theory [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/12/Screenshot-2022-02-26-105443-1.png [figures] => [video] => [the_novelty] =>

This study developed an SP3-coupled global variance reduction (GVR) method, which brought the efficiency and accuracy of the Monte Carlo (MC) criticality calculation to a whole new level. The workflow of the SPN-based GVR involved MC global homogenization in determining global cross-sections, SP3 equation-solving to obtain the global flux distribution, and global weight windows approximation. Despite achieving a noteworthy milestone, this research aimed to enhance the GVR’s performance in the near future by involving rigorous SPN theory and an adjoint method for the SPN theory.

[the_background] =>

The design and performance of a reactor rely significantly on the reactor criticality calculation, which applies the MC method most of the time. Besides enhancing the overall efficiency and accuracy, variance reduction (VR) methods are crucial in maintaining the numerical stability of MC multi-physics simulations. The VR methods developed in the past (i.e. UFS, UTD, UVM) face limitations in terms of working principles, techniques, and validation. To fulfill the demand for a more superior reactor, this study proposed an SP3-coupled GVR that enhanced the overall precision of MC criticality calculation. This development could potentially improve the reactor shielding calculations, leading to a higher-performance reactor.

[the_sdg_impact] =>

A nuclear reactor is built and operated based on sophisticated technology. To cope with the higher demand on its performance, various aspects such as design and safety features need to be enhanced. The GVR method proposed in this study showed great potential in pushing the limits of reactors in the future. Therefore, its achievement materialized UNSDG 9: Industry, Innovation & Infrastructure, by creating a milestone in the nuclear reactor design.

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00973-0 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/12/Reactor-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/12/NST-20_11984989_1639561164.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00973-0 [original_article_reference_fields] => Array ( [publication_title] => SP3-coupled global variance reduction method based on RMC code [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => November 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/y_GI3sIfIEw [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/02/NST-20-with-Chinese-Sub.mp4_snapshot_00.00_2022.03.15_09.37.36.jpg ) ) [87] => WP_Post Object ( [ID] => 31362 [post_author] => 154 [post_date] => 2022-02-26 10:57:26 [post_date_gmt] => 2022-02-26 02:57:26 [post_content] => [post_title] => Nuclear Mass Refinement by Machine Learning [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => nuclear-mass-refinement-by-machine-learning [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:34:21 [post_modified_gmt] => 2022-08-09 02:34:21 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31362 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GAO, Zepeng [researchers_position] => College of Physics Science and Technology, Shenyang Normal University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/12/NST18.png [researchers_profile] => https://www.researchgate.net/profile/Zepeng-Gao-4 [researchers_second_profile] => https://orcid.org/0000-0003-4331-7318 ) [researchers_info_2] => Array ( [researchers_name_2] => WANG, Yongjia [researchers_position_2] => School of Science, Huzhou University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/NST18a.png [researchers_profile_2] => https://www.researchgate.net/profile/Yongjia-Wang [researchers_second_profile_2] => https://orcid.org/0000-0003-2506-0010 ) [original_article_reference] => [research_footprints] => Nuclear mass; Machine learning; Binding energy; Separation energy [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/12/Screenshot-2022-02-26-105340.png [figures] => [video] => [the_novelty] =>

Is there any room to increase the accuracy of theoretical nuclear mass prediction? This study demonstrated that Light Gradient Boosting Machine (LightGBM) is a highly competent tool for improving the accuracy of theoretical nuclear mass and binding energy predicted. With respect to experimental binding energy, LightGBM’s refinement managed to reduce the root mean square deviations (RMSDs) by approximately 90%, 65%, 40%, and 60% in the liquid-drop model (LDM), Duflo–Zucker (DZ) mass model, Weizsäcker–Skyrme (WS4) model, and finite-range droplet model (FRDM) respectively. Consistent RMSD improvement was obtained compared to the 66 newly measured nuclei that appeared in the new atomic mass evaluation, AME2020. Besides that, the LightGBM-refined mass models also yielded single and two-neutron separation energies values that matched those derived experimentally. All it took for the LightGBM to work was the input of characteristic quantities like mass and proton numbers. Relevance analysis of input characteristic quantities for each mass model was carried out using SHapley additive exPlanations (SHAP) and valuable results were obtained for future improvement and development of various nuclear mass models.

[the_background] =>

Nuclear mass has been a crucial and challenging subject, especially for nuclei near the drip lines (i.e., the boundaries delimiting the zone beyond atomic nuclei decay). A Bayesian neural network (BNN) refinement is a promising approach for theoretical models to deduce nuclear mass with higher accuracy. On the other hand, a tree-based learning algorithm developed by Microsoft in 2016, known as LightGBM, shows upsides, including better learning capability, greater efficiency, and better accuracy. This puts LightGBM in an advantageous position to be applied in studies of nuclear mass. As an effort to verify the potentials of the LightGBM machine learning algorithm, this study deployed LightGBM in predicting the masses and binding energy of unknown nuclei. The reduced RMSDs obtained were an excellent validation of LightGBM’s value in nuclear mass studies, which could set a more refined direction for future research.

[the_sdg_impact] =>

The advancement of astrophysics and nuclear physics correlates with the level of knowledge in nuclear mass. Hence, a highly efficient machine learning method is needed to speculate the masses of unknown nuclides, especially superheavy and neutron-rich nuclides. This study validated LightGBM’s potential in nuclear mass studies and, consequently, indicated the importance of machine learning in the progress of astrophysics and nuclear physics. These fundamental findings are essential to facilitate future scientific research by leveraging the ever-evolving technological capability, which aligns with the visions of UNSDG 9: Innovation, industry, and infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00956-1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/12/LightGBM-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/12/NST-18_11984206_1639559402.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00956-1 [original_article_reference_fields] => Array ( [publication_title] => Machine learning the nuclear mass [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => October 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/TNT9jQhsX9s [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2022/02/NST-18-with-Chinese-Sub.mp4_snapshot_00.01_2022.03.15_09.34.23.jpg ) ) [88] => WP_Post Object ( [ID] => 31924 [post_author] => 154 [post_date] => 2022-02-22 14:44:25 [post_date_gmt] => 2022-02-22 06:44:25 [post_content] => [post_title] => Voltage Profiling for Solar Photovoltaic (PV) System in Varying Weather Conditions [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => voltage-profiling-for-solar-photovoltaic-pv-system-in-varying-weather-conditions [to_ping] => [pinged] => [post_modified] => 2022-02-24 09:51:40 [post_modified_gmt] => 2022-02-24 01:51:40 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31924 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MOHD AZMAN, Mohd Arif bin [researchers_position] => Centre for Research and Innovation Management, Universiti Teknikal Malaysia Melaka (UTeM), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/02/solar.png [researchers_profile] => https://www.researchgate.net/profile/Mohd-Azman-6 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Renewable energy; solar photovoltaic; voltage profile intermittency; solar output fluctuation; voltage rise. [graphic_abstract] => [figures] => [video] => [the_novelty] =>

The distribution system of the power grid is affected by the high voltage fluctuation due to the solar PV systems. A grid-connected battery energy storage system is a potential solution. The study analyzed solar PV system voltage profiles and solar power output with four different module technologies at various locations in the free-standing installation method. The study concluded that voltage fluctuation is the highest during the day in both low and high load conditions. Future studies should evaluate the effects of weather and position of solar PV systems against the system’s voltage profile.

[the_background] =>

As more and more people adopt a greener lifestyle, the demand for solar panel reliance has increased in recent years. However, in the usage of solar panel-derived energy, voltage supply seems to fluctuate due to irregular sunlight availability. Such condition poses a negative effect on the power grid, especially the distribution network. Therefore, this study aims to quantify the voltage fluctuation for small-scale solar photovoltaic systems under different loading conditions, specifically voltage and solar power output. The potential solution for this would be a grid-connected battery energy storage system, which allows grid quality and reliability maintenance.

[the_sdg_impact] =>

The increasing adoption of solar power encourages the shift from the current system that uses fossil fuel, promoting cheaper and cleaner energy production. This study strongly associates with Goal 7: Affordable and Clean Energy and Goal 12: Responsible Consumption and Production of the UN’s Sustainable Development Goals (SDG) as the findings are useful for the relevant parties to take suitable actions in improving existing solar PV systems. Ultimately, serving as a good reference for institutions and countries intending to move towards sustainable energy and reduce their environmental impacts through solar power.

[article_url] => https://www.ijrer.org/ijrer/index.php/ijrer/article/view/10450/pdf [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/02/solar2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/02/13776409_1645511914.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.20508/ijrer.v10i1.10450.g7978 [original_article_reference_fields] => Array ( [publication_title] => Quantification of Voltage Profiles Intermittency for Small-Scale Solar Photovoltaic System under Different Loading Conditions [journal_title] => International Journal of Renewable Energy Research-IJRER [publisher] => IJRER [year] => March 2020 [subject] => Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [89] => WP_Post Object ( [ID] => 31906 [post_author] => 154 [post_date] => 2022-02-22 14:21:12 [post_date_gmt] => 2022-02-22 06:21:12 [post_content] => [post_title] => Response Surface Methodology (RSM) for Better Quality Synthetic Rubber [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => response-surface-methodology-rsm-for-better-quality-synthetic-rubber [to_ping] => [pinged] => [post_modified] => 2022-02-22 14:21:12 [post_modified_gmt] => 2022-02-22 06:21:12 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31906 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MAHAMOOD, Mazlin Aida binti [researchers_position] => Centre of Research and Innovation Management (CRIM), Universiti Teknikal Malaysia Melaka (UTeM), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/02/Rubber.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => N/A [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study uses statistical and mathematical models to optimize cure characteristics of Natural Rubber/ EPDM (a type of synthetic rubber) blends. The proposed software identified the optimum mixing parameters (temperature, rotor speed, time) for adding maleic anhydride grafted EPM (MAH-g-EPM). As a result, the miscibility, and physical and rheological properties of the NR/EPDM blend were significantly improved. Thus, creating a more stable rubber blend by increasing the material resistance towards deformation. Such software and analytical technique enable future material characterization to be conducted efficiently across multiple parameters within a short period of time.

[the_background] =>

The blending of two or more elastomers (polymers with elastic properties) is common to obtain new materials with improved and superior properties compared to its original phases at a minimal cost. Applying a similar concept, rubber blends are frequently tested and created to produce newer and sturdier materials for various uses. Natural rubber/EPDM blends are by far the most prominent form of synthetic rubber in terms of performance and elasticity. However, the synthetic rubber blends have shown several mechanical property degradations due to poor compatibility. This study aims to provide suitable and effective cure characteristics of NR/EPDM blends for better miscibility and compatibility.

[the_sdg_impact] =>

Rubber is still widely used in automobile manufacturing along with many other industries for various purposes. According to a March 2021 BBC article, there still is a growing demand for rubber worldwide while there is a shortage in terms of supply. With lands being scarce to accommodate the expansion of rubber plantation, alternative methods are required to make up for the demand. As the use of synthetic rubber increasing, there is a need to constantly improve its quality and durability under minimum expenditure and production time. Thus, the findings of this study clearly promote the enhancement of scientific research to upgrade material production through a more sustainable and efficient use of resources (SDG 9: Industry, innovation and infrastructure).

[article_url] => https://www.scientific.net/AMM.761.441 [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/02/Rubber-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/02/13775783_1645510007.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.4028/www.scientific.net/AMM.761.441 [original_article_reference_fields] => Array ( [publication_title] => Cure Characteristics of Natural Rubber/EPDM Blends for the Effect of MAH Grafted EPM and Compounding Parameters via Response Surface Methodology [journal_title] => Applied Mechanics and Materials [publisher] => Scientific.net [year] => May 2015 [subject] => Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [90] => WP_Post Object ( [ID] => 31882 [post_author] => 154 [post_date] => 2022-02-22 12:14:09 [post_date_gmt] => 2022-02-22 04:14:09 [post_content] => [post_title] => Using Coffee Waste Film in Pulsed Laser Generation [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => using-coffee-waste-film-in-pulsed-laser-generation [to_ping] => [pinged] => [post_modified] => 2022-02-22 12:14:09 [post_modified_gmt] => 2022-02-22 04:14:09 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31882 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LATIFF, Anas Abdul [researchers_position] => Faculty of Electronic & Computer Engineering, Universiti Teknikal Malaysia Melaka (UTeM), Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/02/coffee.png [researchers_profile] => https://www.researchgate.net/profile/Anas-Abdul-Latiff [researchers_second_profile] => https://orcid.org/0000-0002-0092-8082 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Q-switching operation; Ytterbium-doped fiber; Erbium-doped fiber; Thulium-doped fiber; Fiber laser; Saturable absorber; Spent coffee ground [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/02/Generation-of-Q-switched-fiber-laser-at-1.0-1.55-and-2.0-µm-employing-a-spent-coffee-ground-based-saturable-absorber.png [figures] => [video] => [the_novelty] =>

This study demonstrated for the first time a spent coffee ground (SCG) film made of waste product from coffee beans as saturable absorber (SA) for wideband pulsed laser generations. The findings indicate that the fabricated SCG film modulator has a modulation depth, saturable intensity, and non-saturable absorption of 30%, 150 MW/cm2, and 28%, respectively. The fabricated SCG film modulator produced a highest pulse energy of 0.152 μJ and shortest pulse of 4.20 μs at the 1-μm region, which fits the expectations of pulsed laser performance. The SCG film modulator's ability to induce pulsed lasers at various regions, alongside its considerably simple fabrication process, may benefit diverse photonic applications.

[the_background] =>

Pulsed lasers have high pulse energy, with a pulse width that can be tuned up from a microsecond to hundreds of nanoseconds. The active method generation of pulsed lasers in the past is less desirable due to the size, cost, and handling challenges. Hence, passive techniques using modulators have been explored, and nanomaterials like graphene (a form of carbon) are highly preferred in producing such modulators. This study demonstrates the use of waste products from coffee grounds as bio-resources for carbon to synthesize graphene nanomaterials suitable for modulators.

[the_sdg_impact] =>

Global coffee production creates more than 23 million tons of waste per year. Coffee waste is an inexpensive and green alternative for nanomaterials production, which could be applied across various fields. As the pioneering study to utilize waste coffee grounds as bioresources to synthesize graphene nanomaterial for laser technology, it is a great example of enhancing and promoting environmentally sustainable material production with increased resource-use efficiency. Therefore, the study objectives align well with UN Sustainable Development Goal (SDG) 9, Industry, innovation and infrastructure.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S1068520020304247?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/02/coffee-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/02/13773442_1645502737.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.yofte.2020.102434 [original_article_reference_fields] => Array ( [publication_title] => Generation of Q-switched fiber laser at 1.0-, 1.55- and 2.0-µm employing a spent coffee ground based saturable absorber [journal_title] => Optical Fiber Technology [publisher] => Elsevier [year] => January 2021 [subject] => Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [91] => WP_Post Object ( [ID] => 31670 [post_author] => 154 [post_date] => 2022-01-18 11:45:18 [post_date_gmt] => 2022-01-18 03:45:18 [post_content] => [post_title] => High Precision Pre-surgical Intervention Using Newly Improved Epileptogenic Zone Identification Technique in Patients [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => high-precision-pre-surgical-intervention-using-newly-improved-epileptogenic-zone-identification-technique-in-patients [to_ping] => [pinged] => [post_modified] => 2022-01-18 11:45:18 [post_modified_gmt] => 2022-01-18 03:45:18 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31670 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PENG, Syu-Jyun (彭徐鈞 ) [researchers_position] => esearch Center for Artificial Intelligence in Medicine, Taipei Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/01/epileptogenic-.png [researchers_profile] => https://www.researchgate.net/profile/Syu-Jyun-Peng-2 [researchers_second_profile] => https://orcid.org/0000-0001-5002-6581 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Temporal lobe epilepsy; drug resistant; stereoelectroencephalography; SEEG; brain connectivity; topology; complex partial seizures; graph theory [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2022/01/Screenshot-2022-01-18-111058.png [video] => [the_novelty] =>

In the past decade, the usage of stereoelectroencephalography (SEEG) to identify the epileptogenic zone in patients with drug-resistant epilepsy has increased. In this study, researchers used high-frequency oscillations (HFO) in SEEG to distinguish the common changes in the epileptic brain over the course of a seizure. The implementation involved the usage of 3D electrodes implant based on the SEEG methodology. As a result, the onset, propagation, and termination of seizure were identified by observing the high frequency brain waves. The overall change in wave frequency gives a complete map of HFO. Essentially, this HFO map could serve as a biomarker and improve surgical strategy to control/correct seizures with better accuracy and precision. Hence, these new insights would be useful references for researchers and physicians to advance existing epilepsy treatment outcomes.

[the_background] =>

To improve surgical outcomes, it is common to do a non-invasive evaluation prior to surgery to locate the epileptogenic zone (EZ). However, if the EZ is not readily identified, invasive electroencephalography is required. Therefore, it opens the possibility to produce biased data due to a lack of experience. In this study, researchers explore the usage of stereoelectroencephalography (SEEG) to identify ictal high-frequency oscillation (HFO) networks. The primary aim of the study is to develop a new approach for surgery or neuromodulation that may help physicians improve treatment modalities for epilepsy, including resection, cortical stimulation, and neuromodulations treatment that are responsive to network topologies.

[the_sdg_impact] =>

According to a 2019 report from the World Health Organization (WHO), an estimated 50 million people worldwide suffer from epilepsy, making it one of the most common neurological diseases globally. As presented in this study, it is notable that using high-frequency oscillations (HFO) in stereoelectroencephalography (SEEG) can identify the epileptogenic zone (EZ) in the brain. Resection of the areas of the brain where HFOs have been recorded gives a good postsurgical outcome. Thus, the finding of this study would help towards the realization of UNSDG 3: Good Health and Well-Being, which aims to ensure healthy lives and promote well-being for all ages, as well as UNSDG 9: Industry, Innovation and Infrastructure, for its application of research outcome to accelerate A.I.-based medical technology advancement.

[article_url] => https://thejns.org/view/journals/j-neurosurg/131/4/article-p1086.xml [main_image] => https://iesresearch.solutions/wp-content/uploads/2022/01/epileptogenic-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2022/01/TMU-3_12766781_1642473655.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.3171/2018.6.JNS172844 [original_article_reference_fields] => Array ( [publication_title] => Ictal networks of temporal lobe epilepsy: views from high-frequency oscillations in stereoelectroencephalography [journal_title] => Journal of Neurosurgery [publisher] => JNS [year] => Nov 2018 [subject] => Medical; Artificial Intelligence ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [92] => WP_Post Object ( [ID] => 31036 [post_author] => 154 [post_date] => 2021-12-30 11:29:21 [post_date_gmt] => 2021-12-30 03:29:21 [post_content] => [post_title] => Promising Method to Improve Characterization of Heavy Elements using Back-n Neutron Beamline [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => promising-method-to-improve-characterization-of-heavy-elements-using-back-n-neutron-beamline [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:30:32 [post_modified_gmt] => 2022-08-09 02:30:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31036 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HU, Xinrong [researchers_position] => Shanghai Institute of Applied Physics, SLEGS, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST-16-1.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-1677-9528 ) [researchers_info_2] => Array ( [researchers_name_2] => WANG, Hongwei [researchers_position_2] => Shanghai Advanced Research Institute, SLEGS, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST-16-2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0001-7846-4882 ) [original_article_reference] => [research_footprints] => Cross section; 197Au(n, γ); Back-n; C6D6; Pulse height weighting technology [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST_Article-16_V7.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/C6D6-.png [video] => [the_novelty] =>

This study verified the effectiveness of the upgraded CSNS Back-n neutron beamline detection system for neutron capture cross-section measurements using gold (197Au (n, γ)). The new setup included C6D6 detectors and Li-Si flux monitor, the pulse height weighting technique (PHWT) detection technology was used to analysis the data. The results proved that the 197Au (n, γ) reaction cross section measured with neutron energies ranging from 1 eV to 100 keV is consistent with the latest standard evaluations data. Meanwhile, the findings indicated a promising less than 2% statistical uncertainty for the 197Au (n, γ) reaction cross section measured. Therefore, it is evident that the CSNS Back-n neutron beamline facility enhancement proposed in this study would benefit future characterization and the study of synthesis of heavy elements.

[the_background] =>

Neutron-induced reactions have long been used to characterize and synthesize heavy elements. Such techniques have been inspired by the naturally occurring slow neutron capture process (s process) in stars. At present, most neutron capture cross section measurements only one capture criterion for the 197Au (n, γ) reaction with 2.5 MeV thermal neutron energy. Hence, this study proposed integrating C6D6 detectors and PHWT detection technology with the CSNS Back-n neutron beamline. The overall feasibility of the experimental setup was determined by cross-referencing the data with the standard neutron capture cross-section database.

[the_sdg_impact] =>

Neutrons have long played an essential role in engineering materials for nuclear reactors, along with material characterization. As the demand for electric energy grows, so does the demand for potential alternative energy production sources, one of which is nuclear power. Thus, there is a constant need to advance and enhance existing nuclear detection and imaging technology (UN SDG 9: Industry, innovation and infrastructure). The findings of this study could serve as a reference to improve the performance of the current Back-n neutron beamline facility for better heavy chemical elements characterization and data analysis.

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00931-w [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/C6D6-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST-Article-16_11369873_1637313822.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00931-w [original_article_reference_fields] => Array ( [publication_title] => Measurements of the 197Au(n, γ) cross section up to 100 keV at the CSNS Back-n facility [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => September 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/PTYWiJoUmPA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/12/NST-16-with-Chinese-Sub.mp4_snapshot_00.01_2022.01.19_14.24.34.png ) ) [93] => WP_Post Object ( [ID] => 31019 [post_author] => 154 [post_date] => 2021-12-06 11:41:32 [post_date_gmt] => 2021-12-06 03:41:32 [post_content] => [post_title] => Optimization of EAST Performance via Tungsten Control [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => optimization-of-east-performance-via-tungsten-control [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:28:10 [post_modified_gmt] => 2022-08-09 02:28:10 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31019 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => XU, Zong [researchers_position] => College of Physics and Optoelectronic Engineering, Shenzhen University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/15-01.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0001-5852-0250 ) [researchers_info_2] => Array ( [researchers_name_2] => ZHANG, Ling [researchers_position_2] => Division of Plasma Diagnostics, Institute of Plasma Physics, Chinese Academy Science, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/11/15-02.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/ 0000-0001-7880-9588W ) [original_article_reference] => [research_footprints] => Tungsten accumulation; Counter-NBI; Favorable B t; ELMy H-mode; EAST [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST_Article-15.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/Tungsten-.png [video] => [the_novelty] =>

Via experimental investigation on the Experimental Advanced Superconducting Tokamak (EAST), this study reported how the behavior of tungsten (in ELMy H-mode plasmas) could be controlled by neutral beam injection (NBI) and toroidal field (Bt). The concentration of tungsten in the plasma operation was successfully lowered by applying counter-NBI and favorable Bt. It’s crucial to prevent tungsten accumulation and keep tungsten concentration below 10–4 to avoid degradation of plasma confinement and periodic H–L transitions. Future in-depth studies could be carried out to better understand the implications of increased turbulent transport (during the co/counter-NBI phases) on the suppression of tungsten accumulation.

[the_background] =>

Despite being preferred for plasma-facing materials in fusion devices, tungsten tends to accumulate in EAST type-I ELMy H-mode plasmas. Among the adverse outcomes caused by such accumulation include disruption, loss of radiation, and degradation of energy confinement. Meanwhile, literature indicates that tungsten accumulation could be suppressed by controlling the neoclassical transport, inward pinch of high-Z impurities (PHZ), and radial electric field (Er). Furthermore, these three variables were associated with NBI. Thus, this study focused on the potential of NBI in manipulating tungsten behavior in the core of an EAST type-I ELMy H-mode plasma, a mode that led to strong impurity accumulation in EAST. By mastering the technique to avoid tungsten accumulation, the EAST will be able to perform more optimally.

[the_sdg_impact] =>

As the first Tokamak with superconducting toroidal and poloidal magnets, the EAST is valuable for nuclear fusion and plasma research. Thus, its performance stability and consistency are a top priority. By exploring effective methods to minimize tungsten accumulation in the EAST, this research showcased efforts that aligned with the targets of UNSDG 9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00929-4 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/Tungsten-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST-Article-15_11179237_1636683838.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00929-4 [original_article_reference_fields] => Array ( [publication_title] => Tungsten control in type-I ELMy H-mode plasmas on EAST [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => September 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/TkMWeHCEUno [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/12/NST-15-with-Chinese-Sub1.mp4_snapshot_00.00_2022.01.19_14.24.24.png ) ) [94] => WP_Post Object ( [ID] => 31005 [post_author] => 154 [post_date] => 2021-12-02 09:46:36 [post_date_gmt] => 2021-12-02 01:46:36 [post_content] => [post_title] => Successful Designing of Candidate Lattice of SSRF-U Reaching the Soft X-ray Diffraction Limit [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => successful-designing-of-candidate-lattice-of-ssrf-u-reaching-the-soft-x-ray-diffraction-limit [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:25:32 [post_modified_gmt] => 2022-08-09 02:25:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31005 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LIU, Xinzhong [researchers_position] => Accelerator Physics and Technology Department, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/beam-.png [researchers_profile] => https://www.researchgate.net/profile/Liu-Xinzhong-3 [researchers_second_profile] => https://orcid.org/0000-0002-3283-7708 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Diffraction-Limited Storage Ring (DLSR); Shanghai Synchrotron Radiation Facility Upgrade (SSRF-U); Intra-Beam Scattering (IBS); Touschek scattering; Beam lifetime [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST_Article-14_V1-1.jpg [figures] => [video] => [the_novelty] =>

In this study, we design a new lattice of the Shanghai Synchrotron Radiation Facility upgrade (SSRF-U), a low-emittance photon source designed with an emittance of 53.2 pm·rad (N-IBS), using 20 seven-bend achromat cells. This small emittance and high electron density will inevitably lead to non-negligible intra-beam scattering (IBS) and Touschek scattering. Therefore, to weaken the effect of IBS and Touschek scattering, emittance growth and beam lifetime in the SSRF-U storage ring were studied by particle simulation within a series of different machine configurations. After considering almost all the methods, the best configuration was obtained, contributing to the upgrade plan of the SSRF storage ring. The method proposed in this paper would serve as an important reference for transforming other light sources or designing and constructing new light sources.

[the_background] =>

The high-performance SSRF has contributed to significant scientific findings related to various research fields, including biomedicine, material science, environmental science, physics, and chemistry. Meanwhile, there is an increasing demand for synchrotron light sources with reduced beam emittance approaching or reaching X-ray diffraction limits. However, the properties (e.g., beam lifetime and brightness) of such light sources are bound to be degraded by IBS and Touschek scattering. While designing a new lattice of the storage ring, reaching soft-X ray diffraction limit, to upgrade the SSRF, this study has also run extensive simulations to overcome the adverse effects of IBS and Touschek scattering. By identifying the optimal parameters for yielding a beam with lower emittance and higher brightness. The SSRF-U would become one of the state-of-the-art research assets to facilitate scientists making exceptional scientific contributions.

[the_sdg_impact] =>

The SSRF is well-known as a necessary light source facility that contributes to multiple subjects of studies. Despite that, continuous upgrading and improving SSRF are essential to enhance its beam properties and performance to keep up with the rapid pace of scientific research. The candidate lattice of the storage ring for SSRF-U, reaching soft-X ray diffraction limit and Intra-beam scattering optimization, contribute to the upgrade plan of the SSRF storage ring. Hence, this study is well-aligned with the targets of UNSDG 9: Industries, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00913-y [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/beam-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST-Article-14_11178999_1636682860.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00913-y [original_article_reference_fields] => Array ( [publication_title] => Intra-beam scattering and beam lifetime in a candidate lattice of the soft X-ray diffraction-limited storage ring for the upgraded SSRF [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => August 2021 [subject] => Engineering; Nuclear Physics; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/X1zko0nWPag [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/12/NST-14-with-Chinese-Sub.mp4_snapshot_00.01_2021.12.05_15.01.05.png ) ) [95] => WP_Post Object ( [ID] => 31252 [post_author] => 154 [post_date] => 2021-11-26 12:46:38 [post_date_gmt] => 2021-11-26 04:46:38 [post_content] => [post_title] => New Immunotherapy Strategy Shows Promising Results in Treating Various Solid Tumors [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => new-immunotherapy-strategy-shows-promising-results-in-treating-various-solid-tumors [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:50:48 [post_modified_gmt] => 2022-03-08 06:50:48 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31252 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHO, Der-Yang (周德陽) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/CAR-.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => CHIU, Shao-Chih (邱紹智) [researchers_position_2] => Center for Cell Therapy, China Medical University Hospital, Taiwan [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/11/Untitled-1.jpg [researchers_profile_2] => https://www.researchgate.net/profile/Shao-Chih-Chiu [researchers_second_profile_2] => https://orcid.org/0000-0003-1122-3149 ) [original_article_reference] => [research_footprints] => N/A [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/368.png [video] => [the_novelty] =>

This study proposed a novel immunotherapy strategy to treat various solid tumors more effectively and safely. The proposed chimeric antigen receptor (CAR)-T therapy using natural killer (NK) cells, when used to target tumor-associated antigen (TAA), caused lesser damage to healthy tissues. The neoexpressed TAA of interest is known as human leukocyte antigen G (HLA-G). Results indicated that by targeting HLA-G, the proposed CAR-NK successfully triggers the cytotoxic killing response of the immune system when it recognizes the tumor cells. Moreover, the efficacy of the treatment is seen to increase when the tumors are pre-exposed to low-dose chemotherapy. Overall, the study showed promising results under laboratory conditions. However, further studies are suggested to validate the combined effects of chemotherapy and HLA-G CAR-NK cells and expand the application in clinical settings.

[the_background] =>

Among the greatest challenges when treating solid tumors is the immunosuppressive tumor microenvironment (TME), leading to low and ineffective immune responses. Although past attempts using CAR-T to target these immunosuppressive TME showed positive results, severe damages to non-tumor cells have been reported. Moreover, monotherapy of CAR through the conventional techniques have also presented limitation, thus, suggesting a need to explore combined therapies to increase the antitumor capability of the treatment. This study aims to improve the antitumor efficacy of CAR-T treatment strategy by identifying an accurate target and exploring potential combined strategy by understanding the synergistic mechanisms involved.

[the_sdg_impact] =>

In recent years, precision medicine has become a highly sort after area of cancer research. The concept primarily revolves around targeted care through individualized treatment approaches. One such treatment is immunotherapy, sometimes known as biological therapy, which uses the body’s natural defense mechanism to fight cancer. According to a statistic shared by John Hopkins, to date, approximately 15-20% of patients have achieved long-lasting results with the treatment. With most existing treatments still being in the trial phase or displaying a certain amount of limitation, clearly, there is room for further improvement. This study, therefore, could potentially serve as a significant breakthrough in the field by increasing cancer cell target precision and treatment efficacy. Such outcome also aligns with the visions of UN SDG 3: Good health and well-being in reducing the mortality rate of non-communicable diseases, like cancer, through prevention and treatment.

[article_url] => https://jitc.bmj.com/content/9/10/e003050.info [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/immunotherapy-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-18_11534314_1637898011.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1136/jitc-2021-003050 [original_article_reference_fields] => Array ( [publication_title] => Targeting human leukocyte antigen G with chimeric antigen receptors of natural killer cells convert immunosuppression to ablate solid tumors [journal_title] => Journal of Immunotherapy of Cancer [publisher] => BMJ [year] => October 2021 [subject] => Medical; Cancer; Immunotherapy ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/rHkB0MZvwfo [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/18.mp4_snapshot_00.01_2022.02.24_12.10.48.jpg ) ) [96] => WP_Post Object ( [ID] => 31232 [post_author] => 154 [post_date] => 2021-11-26 11:03:05 [post_date_gmt] => 2021-11-26 03:03:05 [post_content] => [post_title] => Reprogramming DNA Replication Mechanism to Stop Cancer Spreading [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => reprogramming-dna-replication-mechanism-to-stop-cancer-spreading [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:53:43 [post_modified_gmt] => 2022-03-08 06:53:43 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31232 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WANG, Shao-Chun (王紹椿) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/DNA-.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-5477-1682 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => PCNA; pY211 PCNA; ssDNA; cGAS; innate immune response; type I interferon [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/DNA-5.jpg [figures] => [video] => [the_novelty] =>

This study proved that disrupting tyrosine-211 phosphorylation of proliferating cell nuclear antigen (pY211-PCNA) is crucial to stopping the spread of breast cancer. By blocking the phosphorylation of the key DNA replication coordinator (PCNA), the replication mechanism collapses. Thus, a series of inflammatory responses outside the tumor cell is triggered. Such immune response is mediated by natural killer (NK) cells which then signal the stop of tumor from spreading any further. These findings provided valuable insights on the previously unclear tumor-promoting signaling pathway. Potentially, such understanding would benefit the development of effective anti-cancer immunotherapy strategies.

[the_background] =>

Cancer cells have a strong replication stress-coping capability, enabling them to divide and grow uncontrollably compared to normal cells. Such characteristic is a result of the ability of these cancer cells to promote DNA damages repair. With that said, much of the underlying signaling mechanisms are still poorly understood. Therefore, this study aims to investigate the mechanisms involved in the regulation of DNA replication within breast cancer cells and understand the impacts on tumor progression.

[the_sdg_impact] =>

According to the statistics provided by WHO, an estimated 2.3 million women were diagnosed with breast cancer, with close to 700 000 deaths reported globally in 2020 alone. Existing treatment often consists of a combination of surgical removal, radiation therapy, and medication to prevent further spreading of the tumor. Hence, to reduce the mortality rate among women with breast cancer, research should explore effective tumor biomarkers and target pathways. By providing significant insights on how cell proliferation mechanisms can be reprogrammed to inhibit tumor growth, this study serves as a good reference in developing future immunotherapy.

[article_url] => https://www.sciencedirect.com/science/article/pii/S2211124721009712 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/DNA-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-20_11517650_1637835236.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.celrep.2021.109537 [original_article_reference_fields] => Array ( [publication_title] => Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA [journal_title] => Cell Reports [publisher] => Elsevier [year] => August 2021 [subject] => Medical; Biomedical Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/efcaQbvWfTY [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/20.mp4_snapshot_00.01_2022.02.24_12.15.28.jpg ) ) [97] => WP_Post Object ( [ID] => 31212 [post_author] => 154 [post_date] => 2021-11-25 23:57:01 [post_date_gmt] => 2021-11-25 15:57:01 [post_content] => [post_title] => Addition of Diabetic Drug Increases Lung Cancer Treatment Effectiveness [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => addition-of-diabetic-drug-increases-lung-cancer-treatment-effectiveness [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:53:07 [post_modified_gmt] => 2022-03-08 06:53:07 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31212 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUANG, Wei-Chien (黃偉謙) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/Smoking-2.png [researchers_profile] => https://www.researchgate.net/profile/Wei-Chien-Huang [researchers_second_profile] => https://orcid.org/0000-0001-6467-8716 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Cancer metabolism; Non-small-cell lung cancer; Predictive markers [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/Smoking-.png [video] => [the_novelty] =>

This study proved that non-small cell lung cancer (NSCLC) patients who smoke are less likely to respond to existing epidermal growth factor receptors tyrosine kinase inhibitor (EGFR TKI) treatment. The findings suggested that by including metformin, a drug for diabetes mellitus, the enzymatic activation of liver kinase B1 – AMP-activated protein kinase (LKB1-AMPK) will produce better response to EGFR TKI and clinical outcomes. This is primarily due to the effectiveness of the combination in improving treatment sensitivity and reducing tumor growth, as shown in both in vitro and in vivo attempts for patients with wild-type LKB1. Thus, confirming the proposed addition of AMPK activator metformin can overcome the treatment resistance experienced by a majority of wild-type EGFR NSCLC patients who smoke. Essentially, such insights are useful to design new therapeutic strategies for NSCLC patients who are least receptive to existing treatments.

[the_background] =>

The EGFR is among the key targets when treating NSCLC. Hence, EGFR TKI has been widely used as part of the initial treatment strategies. However, the clinical outcomes tend to vary in terms of effectiveness for NSCLC patients with wild-type EGFR. Increasingly, reports have associated smoking consequences with the development of lung cancer and the reduction of EGFR TKI treatment responsiveness in NSCLC patients. Therefore, this study aims to understand the EGFR TKI resistance mechanisms in NSCLC patients who smoke. The findings would potentially be used to explore an effective treatment strategy against NSCLC, especially for patients with wild-type EGFR.

[the_sdg_impact] =>

Approximately 80% to 85% of lung cancers are recognized as non-small cell lung cancer (NSCLC). According to the National Cancer Institute of the U.S., smoking cigarettes, pipes, or cigars are major risk factors leading to the development of the disease. By identifying the biological mechanisms that associate cigarette extracts with NSCLC treatment resistance, this study expands the possibility of increasing the effectiveness of the existing treatment. Ultimately, the proposed combination of metformin with EGFR TKI would serve as a new therapeutic strategy to promote treatment response and reduce the mortality rate of patients with NSCLC. (SDG 3: Good health and well-being)

[article_url] => https://www.nature.com/articles/s41388-020-01597-1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/Smoking-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-19_11517556_1637835013.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41388-020-01597-1 [original_article_reference_fields] => Array ( [publication_title] => Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC [journal_title] => Oncogene [publisher] => Springer Nature [year] => December 2020 [subject] => Medical; Lung Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/fVjUVsTyldA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/19.mp4_snapshot_00.01_2022.02.24_12.14.08.jpg ) ) [98] => WP_Post Object ( [ID] => 31192 [post_author] => 154 [post_date] => 2021-11-25 21:29:52 [post_date_gmt] => 2021-11-25 13:29:52 [post_content] => [post_title] => Deciphering a New Bacterial Cyclic AMP–AMP–GMP Synthetase [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => deciphering-a-new-bacterial-cyclic-amp-amp-gmp-synthetase [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:49:14 [post_modified_gmt] => 2022-03-08 06:49:14 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31192 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHEN, Yeh (陳曄) [researchers_position] => Institute of New Drug Development, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/Enzyme.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-7740-0446 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => N/A [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/Enzyme2.jpeg [video] => [the_novelty] =>

This in-situ study reported the crystal structure of EcCdnD, a CD-NTase from Enterobacter cloacae that produces cyclic AMP-AMP-GMP in apo and substrate-bound forms. Besides having two ATP binding sites, its overall structure was different from that of other CD-NTase. Furthermore, the relationships between its structure and activities were discussed in detail. Findings showed that EcCdnD is active when it binds to ATP or a combination of ATP and GTP. Moreover, Mg2+ is the cofactor that contributes the most to the activity of EcCdnD. Based on the results, a catalytic pathway for the CTN-producing EcCdnD is proposed. Further research is needed to confirm the exact catalytic pathway.

[the_background] =>

Cyclic nucleotides are intracellular second messengers that regulate cell function by controlling the activity of protein kinases. Some cyclic dinucleotides (CDNs), which play crucial roles in the immune system, are synthesized by mammalian cyclic GMP-AMP synthase (cGAS) and its homolog dinucleotide cyclase in Vibrio cholerae (VcDncV). Among the recently discovered cGAS/DncV-like nucleotidyltransferases (CD-NTases), only two cyclic-trinucleotides (CTN)-producing Type I CD-NTases had undergone analysis of crystal structure. Therefore, this study was conducted to complement the knowledge gap by determining the structure and activity of EcCdnD in apo-form and when bounded to various substrates and mutants. Along with the possible catalytic mechanisms that produce CTNs, the output of this research serves as a robust reference for future studies of CTN-producing CD-NTases.

[the_sdg_impact] =>

Cyclic nucleotide signaling is an essential cellular central relay system that translates primary signals (e.g., hormonal stimuli or changes in the cellular environment) to a cellular response. Since the structure of bacterial CD-NTases is similar to that of mammalian cGAS and oligoadenylate synthetase (OAS), a better understanding of the former’s properties and catalytic pathway would help advance biomedical sciences. In extension, the biochemical and biophysical studies of EcCdnD in this research potentially contribute to the realization of UNSDG 3: Good Health & Well-Being by expanding the knowledge base of cyclic nucleotides.

[article_url] => https://academic.oup.com/nar/article/49/8/4725/6219115 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/Enzyme4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-16_11517225_1637834200.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1093/nar/gkab165 [original_article_reference_fields] => Array ( [publication_title] => Crystal structure and functional implication of a bacterial cyclic AMP–AMP–GMP synthetase [journal_title] => Nucleic Acids Research [publisher] => Oxford University Press [year] => May 2021 [subject] => Medical; Drug Development ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/ki9dQnEdeIs [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/16.mp4_snapshot_00.01_2022.02.24_12.07.58.jpg ) ) [99] => WP_Post Object ( [ID] => 31172 [post_author] => 154 [post_date] => 2021-11-25 20:46:57 [post_date_gmt] => 2021-11-25 12:46:57 [post_content] => [post_title] => New Advanced Tool for Efficient Study of Lipid Characteristics [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => new-advanced-tool-for-efficient-study-of-lipid-characteristics [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:48:23 [post_modified_gmt] => 2022-03-08 06:48:23 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31172 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHENG, Wei-Chung (鄭維中) [researchers_position] => Graduate Institute of Biomedical Science, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/Lipid-.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-1229-4857 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => N/A [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/Lipid-2.jpeg [figures] => [video] => [the_novelty] =>

Is there an efficient way to simplify the workflows of lipidomic analysis and studies of lipid characteristics? This research develops the first web-based platform, LipidSig, which allows users to conduct in-depth and comprehensive lipidomic analysis efficiently. Users can upload up to four tables of different analysis sections. Based on the data uploaded, LipidSig can carry out five functions (i.e. Profiling, Differential Expression, Correlation, Network, and Machine Learning) to analyze lipidomic change thoroughly. In addition, LipidSig has a unique feature that enables the conversion between lipid species and characteristics according to a user-defined characteristics table. As a web-based tool, there is great potential for LipidSig to be improved and optimized continuously to meet the needs of users.

[the_background] =>

Different from general metabolites, lipids could exert distinct biological functions not only as an individual but also as a group defined by a variety of lipid characteristics (e.g., lipid classes, shapes, double bonds, chain lengths, and hydroxyl groups). To date, one of the bottlenecks faced by lipidomic studies is the lack of analysis tools to efficiently analyze both lipid species and lipid characteristics. Despite the readiness of several tools for analysis of lipid characteristics, some of them impose strict formatting requirements on lipid names, while some can hardly conduct characteristics analyses beyond lipid class, chain length, and double bonds. Hence, this study develops the first web-based tool, LipidSig, which shows high efficiency and flexibility in analyzing streamlined data mining of lipidomic datasets. Being a completely free tool with advanced features, LipidSig provides researchers in lipidomics to further develop and enhance their research.

[the_sdg_impact] =>

Lipids play multiple crucial roles ranging from storing energy to forming signaling molecules. Thus, a comprehensive knowledge base for the diversity and composition of lipids will contribute to more significant discoveries of lipids’ biological functions. The potential of LipidSig in the development of lipidomics has been proven by its features to bridge the existing gaps in the lipid-specific analysis. With that, this study serves as an epitome to enhance physiological and pathological research as well as encourage further scientific discoveries as envisioned in UNSDG9: Industry, Innovation & Infrastructure.

[article_url] => https://academic.oup.com/nar/article/49/W1/W336/6287848 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/Lipid-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-15_11516820_1637833257.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1093/nar/gkab419 [original_article_reference_fields] => Array ( [publication_title] => LipidSig: a web-based tool for lipidomic data analysis [journal_title] => Nucleic Acids Research [publisher] => Oxford University Press [year] => May 2021 [subject] => Medical; Computational Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/zCivFTG7yDs [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/15.mp4_snapshot_00.01_2022.02.24_12.06.22.jpg ) ) [100] => WP_Post Object ( [ID] => 31155 [post_author] => 154 [post_date] => 2021-11-25 20:29:51 [post_date_gmt] => 2021-11-25 12:29:51 [post_content] => [post_title] => Can COVID-19 Infection Cause Autoimmune and Inflammatory Diseases? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => can-covid-19-infection-cause-autoimmune-and-inflammatory-diseases [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:47:26 [post_modified_gmt] => 2022-03-08 06:47:26 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31155 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHEN, Der-Yuan (陳得源) [researchers_position] => College of Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/COVID.png [researchers_profile] => https://www.researchgate.net/profile/Der-Yuan-Chen [researchers_second_profile] => https://orcid.org/0000-0003-1266-1423 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => autoimmune disease; rheumatic disease; COVID-19; SARS-CoV-2; treatment [graphic_abstract] => [figures] => [video] => [the_novelty] =>

Why is the battle against COVID-19 far from over? The coronavirus (SARS-CoV-2) is known to have a complex array of messenger RNA (mRNA) and share molecular similarities with human proteins. Thus, upon infection, extreme autoimmune and inflammatory reactions could be triggered. Based on a systematic review of existing case reports, this study summarized a list of potential triggers of autoimmune and rheumatic diseases following the COVID-19 infection. Among the rare but significant incidences associated are autoimmune cytopenia, cutaneous vasculitis, encephalitis, and Guillain-Barre syndrome. However, it should be noted that most of the literature analyzed was of short-term case reports or case series. For a more definitive conclusion, the study suggests future research to consider establishing a long-term follow-up mechanism.

[the_background] =>

At present, the only available method to defend ourselves from COVID-19 is through vaccination. However, there are rising concerns and hesitancy among vaccine recipients due to its potential to trigger autoimmune and rheumatic complications. Moreover, the rapidly piling up literature makes it even harder for information seekers to acquire reliable and recent resources. Therefore, this study aimed to compile existing evidence from peer-reviewed sources such as PubMed and EMBASE to verify and produce a list of autoimmune and rheumatic diseases potentially associated with COVID-19 infection. Such a thorough overview would benefit vaccine developers in terms of vaccine design and post-marketing surveillance.

[the_sdg_impact] =>

While the UN’s 3rd SDG, Good health and well-being, focused on increasing life expectancy and reducing mortality rates of some common diseases, more efforts are required to manage a wide range of other existing and emerging health issues. The 2020 COVID-19 pandemic has caused a global health crisis where the preparedness of healthcare systems of developed and under-developed nations is equally challenged to manage a threat of such scale. Hence, this study would serve as a good reference for healthcare authorities when handling the global immunization efforts against COVID-19.

[article_url] => https://www.frontiersin.org/articles/10.3389/fimmu.2021.645013/full [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/COVID2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-14_11516771_1637833113.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.3389/fimmu.2021.645013 [original_article_reference_fields] => Array ( [publication_title] => Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review [journal_title] => Frontiers in Immunology [publisher] => Frontiers [year] => March 2020 [subject] => Medical; Covid-19 ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/vHeGg9V9f08 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/14.mp4_snapshot_00.01_2022.02.24_12.04.44.jpg ) ) [101] => WP_Post Object ( [ID] => 31135 [post_author] => 154 [post_date] => 2021-11-25 19:51:29 [post_date_gmt] => 2021-11-25 11:51:29 [post_content] => [post_title] => Inhalation of Heavy Metals Lead to Asthma Development in Children [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => inhalation-of-heavy-metals-lead-to-asthma-development-in-children [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:42:36 [post_modified_gmt] => 2022-03-08 06:42:36 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31135 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HWANG, Bing-Fang (黃彬芳) [researchers_position] => College of Public Health, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/paediatric-.png [researchers_profile] => https://www.researchgate.net/profile/Bing-Fang-Hwang [researchers_second_profile] => https://orcid.org/0000-0002-5951-9662 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Heavy metals; asthma; birth cohort; vulnerable time windows; coexposure [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/asthma.jpg [figures] => [video] => [the_novelty] =>

This study provided evidence that combined exposure to heavy metals (Pb with As, Cd, and Hg) during pregnancy and infancy periods could cause children to develop asthma in later stages. The findings primarily focused on understanding the effects of such exposure on the lung development mechanism and to recognize the sensitive time windows which lead to the risk of asthma development in children. Contrary to most occupational exposure to high levels of heavy metal exposure, even low levels of these components when inhaled during and post-pregnancy by the mother and infant could trigger the disease. The specific sensitive time windows identified are during gestational weeks 1 to 14 and 21 to 40, and 1 to 3 weeks after birth. These results serve as a warning to pregnant women and mothers to avoid getting themselves and their newborns exposed to serious outdoor air pollution.

[the_background] =>

Asthma is a common allergic respiratory disease among children and adults. Much of the causes of this disease are either genetic or environmental. Past studies have linked exposure to air pollution with numerous respiratory diseases development. However, most of these studies evaluate the effects of high levels of heavy metals exposure under working environment. To date, there are limited evidence on the effects of low-level exposures of such poor air quality on children with asthma. Therefore, this study focused on assessing the effects of inhaling traces of heavy metals during and post-pregnancy to determine accurate sensitive time windows.

[the_sdg_impact] =>

Globally, more than 300 million people suffer from asthma. According to the World Health Organization (WHO), the number of patients with asthma is expected to increase by 100 million by 2025. On the other hand, it is undeniable that the air quality has deteriorated over the years due to pollution and high levels of fine particulate matter in the air continue to impose greater health concerns. Thus, the study findings are essential for pregnant women and new mothers to take necessary precaution to avoid exposure to serious air pollution. Moreover, healthcare practitioners could use the findings are a reference to advise the groups at risk to take appropriate measures to ensure the healthy development of their children (SDG 3: Good health and well-being).

[article_url] => https://www.jacionline.org/article/S0091-6749(20)32424-6/ppt [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/asthma-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-10_11516531_1637832514.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.jaci.2020.12.634 [original_article_reference_fields] => Array ( [publication_title] => Combined exposure to heavy metals in PM2.5 and pediatric asthma [journal_title] => Asthma and Lower Airway Disease [publisher] => American Academy of Allergy, Asthma & Immunology [year] => December 2020 [subject] => Medical; Asthma ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/nyBiaJM-Qfs [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/10.mp4_snapshot_00.01_2022.02.24_11.56.03.jpg ) ) [102] => WP_Post Object ( [ID] => 31118 [post_author] => 154 [post_date] => 2021-11-25 19:26:45 [post_date_gmt] => 2021-11-25 11:26:45 [post_content] => [post_title] => High Pre-surgery Blood Sugar Levels Can Extend Patient Hospitalization Period [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => high-pre-surgery-blood-sugar-levels-can-extend-patient-hospitalization-period [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:36:52 [post_modified_gmt] => 2022-03-08 06:36:52 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31118 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KUO, Chin-Chi (郭錦輯) [researchers_position] => College of Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/blood-.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-2050-1377 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => N/A [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This research evaluated the risk of prolonged hospital stay as a result of high blood sugar levels recorded before non-critical surgeries regardless of patient diabetic status. A large retrospective cohort study was conducted by analyzing patients' medical records of appendectomy and laparoscopic cholecystectomy at China Medical University Hospital (CMUH), Taiwan, between 2003 and 2016. The findings proved that patients with higher preoperative blood glucose (POBG) level undergoing these standard procedures are more likely to have an extended hospitalization than those with lower POBG levels. To be precise, appendectomy patients with POBG levels of ≥123 mg/dL are 19% more likely to stay beyond 3 days in the hospital, while laparoscopic cholecystectomy patients with POBG levels of ≥128 mg/dL had a 17% higher risk. Thus, it was concluded that the optimal POBG level with reduced risks might be lower than the current standards for common surgeries. Such insight could improve existing clinical practice guidelines for patients undergoing surgery to ensure an effective recovery experience.

[the_background] =>

There is an ongoing debate on whether routine blood sugar levels before surgery are necessary for healthy or asymptomatic adults. To date, there are no fixed guidelines available for such assessment, especially for those undergoing elective non-critical surgical procedures. However, increasing evidence has shown that high preoperative blood sugar levels do harm surgical patients. Hence, this research aimed to assess the effect of POBG level on hospital length of stay in patients undergoing appendectomy or laparoscopic cholecystectomy, both of which are highly standardized and regulated non-critical procedures. The findings would serve as a potential basis for exploring the role of POBG levels in determining factors affecting patient recovery.

[the_sdg_impact] =>

The Lancet Commission on Global Surgery (LCoGS) 2030 report, supported by WHO, aims to strengthen global surgical ecosystems, especially by focusing on the integration of emergency and essential surgical care within universal health coverage (UHC) plans (Global Surgery 2030). From a broader perspective, these efforts are directed to enable economic growth, UHC, and the achievement of UN SDGs. When looked at closely, the findings of this research could potentially play an important role in improving under-addressed surgical issues and providing quality healthcare services for patients (SDG 3: Good health and well-being).

[article_url] => https://care.diabetesjournals.org/content/44/1/107 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/blood-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-4_11515818_1637830613.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.2337/dc19-0963 [original_article_reference_fields] => Array ( [publication_title] => Association Between Preoperative Blood Glucose Level and Hospital Length of Stay for Patients Undergoing Appendectomy or Laparoscopic Cholecystectomy [journal_title] => Diabetes Care [publisher] => American Diabetes Association [year] => October 2020 [subject] => Medical; Diabetes ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/rPJU1egjeRk [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/04.mp4_snapshot_00.04_2022.02.24_11.44.29.jpg ) ) [103] => WP_Post Object ( [ID] => 31098 [post_author] => 154 [post_date] => 2021-11-25 18:33:52 [post_date_gmt] => 2021-11-25 10:33:52 [post_content] => [post_title] => Characterization of Initial Key Steps of IL-17 Receptor B Oncogenic Signaling for Targeted Therapy of Pancreatic Cancer [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => characterization-of-initial-key-steps-of-il-17-receptor-b-oncogenic-signaling-for-targeted-therapy-of-pancreatic-cancer [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:19:14 [post_modified_gmt] => 2022-03-08 06:19:14 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31098 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LEE, Wen-Hwa (李文華) [researchers_position] => Drug Development Center, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/pancreatic-.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Wen-Hwa-Lee-38659564 [researchers_second_profile] => https://orcid.org/0000-0002-4098-5225 ) [researchers_info_2] => Array ( [researchers_name_2] => WU, Heng-Hsiung (吳恒祥) [researchers_position_2] => Drug Development Center, China Medical University, Taiwan [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/11/pancreatic-2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-4098-5225 ) [original_article_reference] => [research_footprints] => N/A [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study includes different proteomics, genomics, and imaging experiments conducted on in-vitro (cellular) and in-vivo (animal) models. The findings established the role of interleukin 17 receptor B (IL-17RB) in tumorigenesis and metastasis of pancreatic cancer via a distinct pathway. It revealed that the phosphorylation of tyrosine-447 (Y447) is highy important for IL-17 induced signaling IL-17RB, which associates with clinically aggressive pancreatic tumors. Upon discovering the importance of mixed-lineage kinase 4 (MLK4) in IL-17RB signal transduction, it was found that two identical subunits of IL-17RB need to form a complex, a homodimerize, to be able to recruit MLK4. Moreover, phosphorylation of IL-17RB at Y447 proved vital for the recruitment of other important proteins for its downstream signaling pathway. The significance of these findings was further validated when treatment with a loop peptide dampened the phosphorylation of Y447 and reduced metastasis progression in pancreatic cancer. By understanding the signaling mechanism of IL-17RB which triggers tumorigenesis, potential treatment strategies for pancreatic tumors can be further explored.

[the_background] =>

Unlike other IL-17 receptors, the role and physiological nuances of IL-17RB in inflammation or pancreatic cancer remain unclear in past studies. Similarly, the binding of ligand IL-17 to the homodimer or heterodimer complex of the receptor was unknown. This study has not just answered these questions but also demonstrated the signal transduction and mediators involved in binding IL-17 to IL-17RB to elicit its tumorigenicity. The findings proved that inhibiting IL-17RB activation diminishes tumorigenesis and metastasis, reducing pancreatic tumor development, especially in-vivo. One of the limitations of the study is the inability to assess the conformational change of the receptor to recruit related mediators, which opens avenue for future studies to validate this using cryo-electron microscopy. In addition, modification on the loop peptide to target critical steps involved in IL-17RB oncogenic signaling will potentially reveal new chemical entities as candidates for treatment in pancreatic cancer.

[the_sdg_impact] =>

The incidence of pancreatic cancer has been increasing by the year. In 2020, close to 500,000 new pancreatic cancer incidences were recorded globally, and an almost equal number of people died of the disease. Thus, making it the 7th most common cause of cancer-related death (WHO, 2020). It is worrying that high mortality and incidence of the malignancy are correlated to high prevalence of other comorbidities, implying compromised quality of life. Hence, it is highly crucial to invest in discovering more effective treatments for this cancer to support United Nations Sustainable Development Goal (UNSDG)3: Good health and well-being, to empower the health of the global community to improve the quality of human capital.

[article_url] => https://www.science.org/doi/10.1126/scitranslmed.abc2823 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/pancreatic-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-3_11487500_1637741436.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1126/scitranslmed.abc2823 [original_article_reference_fields] => Array ( [publication_title] => Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer [journal_title] => Science Translational Medicine [publisher] => AAAS [year] => March 2021 [subject] => Medical; Pancreatic cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Y6UFLPIeFW4 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/03.mp4_snapshot_00.01_2022.02.24_11.41.33.jpg ) ) [104] => WP_Post Object ( [ID] => 31067 [post_author] => 154 [post_date] => 2021-11-22 19:49:52 [post_date_gmt] => 2021-11-22 11:49:52 [post_content] => [post_title] => Understanding the Least Explored Branching Patterns of a Jellyfish’s Tentacles [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => understanding-the-least-explored-branching-patterns-of-a-jellyfishs-tentacles [to_ping] => [pinged] => [post_modified] => 2022-03-08 16:05:45 [post_modified_gmt] => 2022-03-08 08:05:45 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=31067 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KUMANO, Gaku (熊野岳) [researchers_position] => Asamushi Research Center for Marine Biology, Graduate School of Life Science, Tohoku University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/medusa-.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Adhesive organ; Branching morphogenesis; Cladonema pacificum; Cnidarian; Jellyfish; Medusa tentacle; Mesoderm; Nematocyst; RTK signaling [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/medusa-2.png [video] => [the_novelty] =>

This study highlights the unique formation of medusa tentacles in jellyfish, C. pacificum, and the mechanisms involved. The formation of these tentacles followed a simple branching rule observed only in this species combined with a specific cell signalling, mitogen-activated protein kinase kinase (MEK) signalling. Findings indicated that tentacles branch through repeated addition of new branches to the proximal region of the main tentacle during the elongation process. Noticeably, the use of a simple rule to create complex branched structures is also found in branching morphogenesis of other animals such as Drosophila and mammals. In addition, receptor tyrosine kinase signalling could be required for the C. pacificum tentacle branch formation just like organ branch formation in Drosophila and mammals. Results also showed that changing functions of the branches from sticking to surfaces to hunting prey during the development process. As a whole, such an in-depth understanding of the unique branching features of a least studied species like the jellyfish could potentially benefit future animal development studies.

[the_background] =>

Branched structures are formed in certain organs of various species to carry out a range of functions. Previous literature showed the formation and functions in fruit flies’ trachea and mammalian organs such as lungs. Generally, branched tentacles are rare in jellyfishes except for jellyfishes in the Cladonematidae family. It is currently unclear how different or conserved mechanisms are involved in forming branched organs across the animal kingdom, as most available literature focused primarily on fruit flies and mammals. Therefore, this study aims to provide descriptive and functional information on the branching pattern of branched tentacles in jellyfishes.

[the_sdg_impact] =>

N/A

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0124-4 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/medusa-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/Zoology-08_11434571_1637580283.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0124-4 [original_article_reference_fields] => Array ( [publication_title] => Branching pattern and morphogenesis of medusa tentacles in the jellyfish Cladonema pacificum (Hydrozoa, Cnidaria) [journal_title] => Zoological Letters [publisher] => BMC [year] => March 2019 [subject] => Zoology; Biological Sciences ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [105] => WP_Post Object ( [ID] => 30985 [post_author] => 154 [post_date] => 2021-11-22 17:39:49 [post_date_gmt] => 2021-11-22 09:39:49 [post_content] => [post_title] => Uncovering the Mechanism for Treating Depression [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => uncovering-the-mechanism-for-treating-depression [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:50:05 [post_modified_gmt] => 2022-03-08 06:50:05 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=30985 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SU, Kuan-Pin (蘇冠賓) [researchers_position] => Departments of Psychiatry, and Mind-Body Interface Laboratory, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/Kuan.png [researchers_profile] => https://www.researchgate.net/profile/Kuan-Pin-Su [researchers_second_profile] => https://orcid.org/0000-0002-4501-2502 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Cell biology; Molecular biology; Neuroscience [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/dha-4.png [video] => [the_novelty] =>

What is the molecular mechanism underlying the potential of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) in treating depression and reducing neuron inflammation? Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found to have antidepressant, anti-inflammatory, and neuroprotective effects. For the first time, this study identified lipoxygenase (LOX) and cytochrome P450 (CYP450) EPA/DHA metabolites as the mediators of the protective effect of these ω-3 PUFAs. Lipid mediators hydroxyeicosapentaenoic acid (HEPE), hydroxydocosahexaenoic acid (HDHA), epoxyeicosatetraenoic acid (EpETE), and epoxydocosapentaenoic acid (EpDPA) were detected in the human brain after EPA and DHA were metabolized. Therefore, co-treatment with soluble epoxide hydroxylase (sEH) enzyme inhibitor, TPPU, was able to amplify the protective effects. Consistent results were obtained from both in vitro and clinical studies. As an extension, the research will involve a larger cohort of depressed patients and other forms of ω-3 PUFAs metabolites, such as endocannabinoids, in the future.

[the_background] =>

A correlation between severe depression and inflammation was reported in past studies. However, even though EPA and DHA were proven to exhibit anti-inflammatory and antidepressant properties, its mechanism remained obscure. Therefore, an effective anti-inflammatory treatment strategy is crucial. Meanwhile, there was no evidence from past literature that ω-3 lipid metabolites were produced in the human brain. For the first time, this study demonstrated that EPA and DHA were broken down in neurons into lipid mediators, which improved depressive symptoms. These findings are crucial in developing an effective therapeutic strategy for depression and other inflammation-associated brain disorders.

[the_sdg_impact] =>

Approximately 280 million people worldwide suffer from depression, the most common mental disorder leading to suicide. More importantly, to date, there is no effective treatment that is safe for daily use. Hence, by uncovering the mechanism in which EPA and DHA exhibit anti-inflammatory and antidepressant properties, an effective therapeutic supplement can be developed to curb depression with minimal adverse effects. In short, the output of this study contributes significantly to the development of medicines for inflammation-associated brain disorders, fulfilling UNSDG 3: Good Health & Well-Being.

[article_url] => https://www.nature.com/articles/s41380-021-01160-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/DHA-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-17_11431544_1637573469.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41380-021-01160-8 [original_article_reference_fields] => Array ( [publication_title] => Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis [journal_title] => Molecular Psychiatry [publisher] => Springer Nature [year] => June 2021 [subject] => Medical; Psychiatry; Depression ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/3ZglG8yB4Lo [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/17.mp4_snapshot_00.00_2022.02.24_12.09.27.jpg ) ) [106] => WP_Post Object ( [ID] => 30963 [post_author] => 154 [post_date] => 2021-11-22 17:21:18 [post_date_gmt] => 2021-11-22 09:21:18 [post_content] => [post_title] => New Protein Target as Treatment Strategy in Metastatic Lung Cancer [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => new-protein-target-as-treatment-strategy-in-metastatic-lung-cancer [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:44:18 [post_modified_gmt] => 2022-03-08 06:44:18 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=30963 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SHER. Yuh-Pyng (佘玉萍) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/BASP1-.png [researchers_profile] => https://www.researchgate.net/profile/Yuh-Pyng-Sher [researchers_second_profile] => https://orcid.org/0000-0002-6062-7556 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => lung adenocarcinoma; BASP1; arsenic trioxide; EGFR-TKI acquired resistance; combination therapy [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/BASP1-5.png [video] => [the_novelty] =>

The study identified an interaction between epidermal growth factor receptor (EGFR) and brain acid soluble protein-1 (BASP1) that contributes to EGFR signaling in brain metastatic lung cancer. The results demonstrated that BASP1 is associated with poorer outcomes, enhances cellular proliferation, and colony formation in lung cancer. The BASP1 role in tumorigenicity was proven via in-vitro and in-vivo by investigating the migration and metastatic potential of the protein of interest in this tumor. One of the most important discoveries of this research is the interaction between BASP1 and EGFR that enhances EGFR signaling, which activates a positive feedback loop by recruitment of BASP1 to lipid rafts. This finding enabled the researchers to identify the harmful impact of BASP1 in reducing drug sensitivity in lung cancer treatment. The light shed on the role of BASP1 via these discoveries encouraged the scientists to identify potential synergistic treatment options for lung cancer with arsenic trioxide and tyrosine kinase inhibitors (TKI) combination. Future studies exploring the functions of BASP1 based on its localization in different tumors can further reveal the universal role of the protein in various malignancies.

[the_background] =>

TKIs targeting EGFR are among the first-line treatment options for metastatic non-small cell lung cancer (NSCLC). However, the development of resistance over time eventually renders the treatment ineffective. Hence, it becomes crucial to discover therapeutic strategies that inhibit alternative tumor survival signaling pathways that maintain persistent oncogenic EGFR signaling. This study explored the interaction between BASP1 and EGFR, especially in lung cancer with brain metastasis, and investigated potential combination treatment that targets the BASP1-EGFR axis to overcome TKIs resistance. Contrary to the known function of BASP1 as a tumor suppressor, the study revealed that BASP1 is highly expressed and associated with poorer outcomes in brain metastasis. The findings highlighted a promising outcome through blockage of the positive feedback loop between EGFR and BASP1. Thus, paving the way for future research on potential treatment strategies using EGFR TKIs for lung cancer.

[the_sdg_impact] =>

According to WHO, lung cancer is the most common cause of cancer-related deaths in 2020, accounting for 1.8 million deaths with 2.21 million new cases recorded. The death to new cases ratio is the highest for lung cancer, urging the discovery of an effective therapeutic regimen for the disease, especially in brain metastatic lung cancer. This study focused on identifying the molecular basis behind therapeutic failure and poor prognosis in lung cancer. Ultimately, the findings would contribute to developing possible resistant-free and more effective treatment for lung cancer. Such a study is necessary to improve clinical management of the disease and potentially reduce mortality rates (SDG 3: Good health and well-being).

[article_url] => https://www.thno.org/v10p10925.htm [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/BASP1-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-12_11156388_1636615301.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.7150/thno.49425 [original_article_reference_fields] => Array ( [publication_title] => Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression [journal_title] => Nanotheranostics [publisher] => Theranostics [year] => August 2020 [subject] => Medical; Biomedical Sciences; Lung Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/uGn6cKYKv80 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/12.mp4_snapshot_00.01_2022.02.24_12.00.04.jpg ) ) [107] => WP_Post Object ( [ID] => 30944 [post_author] => 154 [post_date] => 2021-11-22 16:55:26 [post_date_gmt] => 2021-11-22 08:55:26 [post_content] => [post_title] => Potential Environmental cause of Allergic Rhinitis Development in Children [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => potential-environmental-cause-of-allergic-rhinitis-development-in-children [to_ping] => [pinged] => [post_modified] => 2022-03-08 14:40:05 [post_modified_gmt] => 2022-03-08 06:40:05 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=30944 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HWANG, Bing-Fang (黃彬芳) [researchers_position] => College of Public Health, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/paediatric-.png [researchers_profile] => https://www.researchgate.net/profile/Bing-Fang-Hwang [researchers_second_profile] => https://orcid.org/0000-0002-5951-9662 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => asthma epidemiology; clinical epidemiology; paediatric lung disaese [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This study further affirms that exposures to fine particulate matter (PM2.5) during late pregnancy and early infancy increase the risk of allergic rhinitis (AR) development in a later stage. Despite the past association of PM2.5 exposure with the cause of AR, this is the first birth cohort study to identify the vulnerable time window, which is from gestation to early childhood. Potentially, such a scenario is triggered by the exposure of PM2.5 during critical stages of the sino-nasal development during late pregnancy and early infancy stages. The results would serve as a reference to determine the appropriate methods to decrease adverse effects of the condition. That said, further investigation on PM2.5 association with AR development is needed to verify the vulnerable time window suggested by this study.

[the_background] =>

Allergic rhinitis (AR), also called hay fever, is a series of inflammatory reactions triggered by environmental or indoor allergens, such as pollen, dust, skin flake, and mold. While AR is not a life-threatening disease, the array of symptoms associated with the condition is known to cause significant inconvenience to those diagnosed with it. Past studies have linked fine particulate matter (PM2.5) exposure with several allergic respiratory diseases, yet its role in AR development remains unclear. Moreover, there are conflicts between findings in Asian and Western countries regarding long-term PM2.5 exposure and AR incidence. Therefore, this study combined a large population-based birth cohort study with satellite data to identify the PM2.5 exposure period and evaluate its impact on the onset of AR.

[the_sdg_impact] =>

An article in Medscape highlighted that allergic rhinitis incidence had increased worldwide. Approximately 40% of children are affected, of which the highest prevalence of severe AR is found in Africa and Latin America. Similarly, the air quality has deteriorated over the years due to pollution and high levels of fine particulate matter in the air continue to impose greater health concerns. Thus, the study findings are essential to healthcare practitioners to advise expectant mothers and mothers of newborns to take appropriate measures to ensure the healthy development of their children (SDG 3: Good health and well-being).

[article_url] => https://thorax.bmj.com/content/early/2021/01/26/thoraxjnl-2020-215025.info?versioned=true [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/paediatric-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/11/CMU-Article-9_11155875_1636613298.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1136/thoraxjnl-2020-215025 [original_article_reference_fields] => Array ( [publication_title] => Effect of exposure to fine particulate matter during pregnancy and infancy on paediatric allergic rhinitis [journal_title] => Environmental Exposure [publisher] => BMJ [year] => June 2021 [subject] => Medical; Occupational Safety and Health ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/zOJwcze0fqM [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/11/09.mp4_snapshot_00.01_2022.02.24_11.54.19.jpg ) ) [108] => WP_Post Object ( [ID] => 29913 [post_author] => 154 [post_date] => 2021-09-28 09:31:57 [post_date_gmt] => 2021-09-28 01:31:57 [post_content] => [post_title] => Neutral Particle Analyzer Optimizing to Improve Tokamak Performance [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => neutral-particle-analyzer-optimizing-to-improve-tokamak-performance [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:17:19 [post_modified_gmt] => 2022-08-09 02:17:19 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29913 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LUO, Yuan (罗圆) [researchers_position] => Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/Yuan-Luo.png [researchers_profile] => https://www.researchgate.net/profile/Yuan-Luo-36 [researchers_second_profile] => https://orcid.org/0000-0001-5982-8476 ) [researchers_info_2] => Array ( [researchers_name_2] => LIN, Weiping (林炜平) [researchers_position_2] => Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/08/weiping.png [researchers_profile_2] => https://www.researchgate.net/profile/Weiping-Lin-5 [researchers_second_profile_2] => https://orcid.org/0000-0002-1971-4025 ) [original_article_reference] => [research_footprints] => pressure distribution; International Thermonuclear Experimental Reactor; GEANT4; cross section; magnetic field; experimental advanced superconducting tokamak; Tokamak Fusion Test Reactor; computational fluid dynamics; charge exchange; Joint European Torus [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/08/NST_Article-12_V0.jpg [figures] => [video] => [the_novelty] =>

This study constructed a windowless gas stripping room with two differential pipes in a neutral particle analyzer (NPA) with parallel electric and magnetic fields (E//B), a diagnosis device in Tokamak (toroidal device used in nuclear fusion research for magnetic confinement plasmas). As a result, the new design eliminated the replacement of stripping foils and eased the operation maintenance process. Moreover, multiple simulations, such as ANSYS Fluent, MolFlow+, and GEANT4, were applied to evaluate the design performance in terms of gas pressure distribution and stripping efficiency. It was identified that the optimum pressure for maximum global efficiency is 240 Pa. In the long run, the findings could improve the NPA diagnosis for the nuclear fusion study.

[the_background] =>

As a diagnosis device in the Tokamak, an NPA measures the charge exchange neutral particles escaping from plasma. Its functions include studying the energy distribution of fast ions and the isotopic ratio of the plasma. An NPA consists of a stripping unit that re-ionizes the neutral particles escaping from the Tokamak through charge exchange reactions. The stripping unit comprises stripping material in the form of either stripping foil or stripping gas. This study designs and simulates a windowless gas stripping room with two differential pipes in an E//B NPA to improve the device’s performance and maintenance, especially in terms of optimum pressure for maximum global efficiency. The simulation results would serve as a reliable reference for future practical applications.

[the_sdg_impact] =>

At present, power plants generate electricity and energy through fossil fuels, nuclear fission, or renewable energy sources. A Tokamak is an experimental machine designed to harness the energy of nuclear fusion, potentially serving as an alternative to future energy generation. To turn such experimental design into reality, it is crucial for researchers to constantly explore new ways to improve and maintain the performance of the Tokamak facility. Therefore, the findings of this study contribute to the efforts of the understanding and the betterment of the device. It would eventually be beneficial to advance the future of energy production. (UNSDG 9: Industry, Innovation & Infrastructure)

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00909-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/Tokamak.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/Tokamak_9172752_1629889514.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00909-8 [original_article_reference_fields] => Array ( [publication_title] => A simulation study of a windowless gas-stripping room in an E//B neutral particle analyzer [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => July 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/KlXHAUDjVik [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/09/NST-12-with-Chinese-Sub.mp4_snapshot_00.01_2021.11.09_11.13.37.png ) ) [109] => WP_Post Object ( [ID] => 29930 [post_author] => 154 [post_date] => 2021-09-26 16:17:47 [post_date_gmt] => 2021-09-26 08:17:47 [post_content] => [post_title] => Fast and Accurate Way to Detect Special Nuclear Materials Being Smuggled [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => fast-and-accurate-way-to-detect-special-nuclear-materials-being-smuggled [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:20:33 [post_modified_gmt] => 2022-08-09 02:20:33 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29930 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LAN, Haoyang [researchers_position] => School of Nuclear Science and Technology, University of South China, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/Haoyang-Lan.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0003-4117-9097 ) [researchers_info_2] => Array ( [researchers_name_2] => LUO, Wen [researchers_position_2] => School of Nuclear Science and Technology, University of South China, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/08/nst-13-c.png [researchers_profile_2] => https://www.researchgate.net/profile/Luo-Wen-9 [researchers_second_profile_2] => https://orcid.org/0000-0003-0043-8769 ) [original_article_reference] => [research_footprints] => region of interest; standard deviation; nuclear material; nuclear resonance fluorescence; spectroscopy; special nuclear material [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/09/NST_Article-13_V2-2.jpg [figures] => [video] => [the_novelty] =>

This study proposed an improvement to the existing special nuclear materials (SNMs) detection models by combining two spectroscopy techniques, i.e., scattering nuclear resonance fluorescence (sNRF) and transmission-NRF-based computed tomography (tNRF-CT). The combination enabled the proposed detector to identify isotopic composition and spatial distribution of 235,238U when concealed in a 3-cm diameter iron rod. The outcome indicated a shortened interrogation time by one order of magnitude, making it a more rapid and sensitive option than the current tNRF-CT approach. Thus, the successful attempt of the proposed model in lowering the missed-detection rate within a realistic interrogation time would be of great value to upgrade national and global security systems.

[the_background] =>

The integrity of global security has constantly been threatened due to the potential smuggling of special nuclear materials (SNMs) across borders and through ports of entry. As a matter of fact, the Incident Trafficking Database developed by the International Atomic EnergyAgency has reported several hundred incidents of illicit trafficking and malicious use of certain nuclear and radioactive materials. Existing passive detection systems are ineffective when the interrogated SNMs are shielded, considering the low spontaneous radiation intensity and energy emitted in most cases. Therefore, this study proposed an active detection technique that uses external radiation sources to develop a more accurate, effective, and practical approach to non-destructively inspect SNMs, especially uranium.

[the_sdg_impact] =>

International organizations such as the Nuclear Threat Initiative (NTI) in the U.S. and the United Nations Office for Disarmament Affairs (UNODA) are constantly trying to strengthen global security against threats, one of which is nuclear terrorism. Hazardous nuclear materials falling into the wrong hands could lead to catastrophic events ranging from poisoning and radiation burns to nuclear attacks. To prevent such incidents, security systems need to be constantly upgraded, especially in terms of material inspections at borders, ports, and checkpoints. This study proposed a feasible technique to improve the non-destructive inspection capability of special nuclear material (SNM) through an innovative combination of imaging technologies. The outcome indicates that integration of such techniques could be beneficial to strengthening national and international security systems against nuclear smuggling, in extension, maintaining world peace. (UNSDG 9: Innovation, industry and infrastructure; UNSDG 16: Peace, justice and strong institutions)

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00914-x [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/nuclear-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/nuclear_9173357_1629891291.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00914-x [original_article_reference_fields] => Array ( [publication_title] => Rapid interrogation of special nuclear materials by combining scattering and transmission nuclear resonance fluorescence spectroscopy [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => August 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/slw8Ph_C8gU [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/09/NST-13-with-Chinese-Sub.mp4_snapshot_00.01_2021.12.02_10.03.42.png ) ) [110] => WP_Post Object ( [ID] => 30579 [post_author] => 154 [post_date] => 2021-09-26 11:08:04 [post_date_gmt] => 2021-09-26 03:08:04 [post_content] => [post_title] => Baseline Test Results of 650 MHz Cavities BCP Treated for CEPC [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => baseline-test-results-of-650-mhz-cavities-bcp-treated-for-cepc [to_ping] => [pinged] => [post_modified] => 2022-08-09 10:11:43 [post_modified_gmt] => 2022-08-09 02:11:43 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=30579 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SHA, Peng (沙鹏) [researchers_position] => Accelerator Division, Institute of High Energy Physics, Chinese Academy of Sciences, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/09/CEPC.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0003-2545-7974 ) [researchers_info_2] => Array ( [researchers_name_2] => HAO, Jiankui (郝建奎) [researchers_position_2] => State Key Laboratory of Nuclear Physics and Technology & Institute of Heavy Ion Physics, Peking University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/09/CEPC2.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0001-6653-1574 ) [original_article_reference] => [research_footprints] => radio frequency; superconducting radio frequency; Fermi National Accelerator Laboratory; circular electron positron collider; quality factor [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/09/NST_Article-11_V1.jpg [figures] => [video] => [the_novelty] =>

This study has found that nitrogen doping/infusion could increase the intrinsic quality factor (Q0) of the 650 MHz cavities used in a circular electron-positron collider (CEPC). Adopting a buffered chemical polishing (BCP) surface baseline prior to the nitrogen infusion of a 650 MHz 2-cell cavity yielded a Q0 of 6 × 1010 at 22 MV/m in the vertical test and a maximum gradient of 25 MV/m. The Q0 exceeded the specification of CEPC, i.e., 4 × 1010 at 22 MV/m. By optimizing nitrogen infusion and BCP, the performance of the 650 MHz cavity can be further enhanced.

[the_background] =>

The CEPC is a high-energy collider of the Higgs factory. Constructed 100 m underground, two hundred and forty 650 MHz 2-cell cavities and ninety-six 1.3 GHz 9-cell cavities exist in the collider and the booster. The 650 MHz 2-cell cavities economically support the cryogenics system by operating in continuous wave mode with high-quality factor (Q). Electro-polishing (EP) is commonly adopted for the nitrogen doping/infusion of the cavities abroad. However, in China, buffered chemical polishing (BCP) is relatively more feasible to be adopted instead. This study conducted a nitrogen infusion and doping study on 650 MHz cavities BCP treated to confirm its feasibility. Results showed that the Q0 achieved exceeded the specifications of CEPC. Therefore, nitrogen doping/infusion of cavities BCP treated is effective and easy to promote.

[the_sdg_impact] =>

Superconducting cavities with high Q and gradient are advocated by many applications, such as wastewater and sludge treatment, safety, flue gas treatment, nuclear waste destruction, etc. The highly effective BCP surface baseline reported in this study offers an alternative option to researchers seeking a feasible surface baseline for nitrogen doping/infusion besides EP. Hence, this study aligns with the objectives of UNSDG 9: Industry, Innovation & Infrastructure, to enhance scientific research.

[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00881-3 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/09/CEPC3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/09/CEPC_10002421_1632624971.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00881-3 [original_article_reference_fields] => Array ( [publication_title] => Nitrogen doping/infusion of 650 MHz cavities for CEPC [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => May 2021 [subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/yenlMb-7ZPI [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/09/NST-11-with-Chinese-Sub1.mp4_snapshot_00.01_2021.12.02_10.01.01.png ) ) [111] => WP_Post Object ( [ID] => 30527 [post_author] => 154 [post_date] => 2021-09-17 10:33:30 [post_date_gmt] => 2021-09-17 02:33:30 [post_content] => [post_title] => Formation of Fin Rays Pattern of Zebrafish [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => formation-of-fin-rays-pattern-of-zebrafish [to_ping] => [pinged] => [post_modified] => 2022-02-03 13:30:12 [post_modified_gmt] => 2022-02-03 05:30:12 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=30527 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TAMURA, Koji (田村宏治) [researchers_position] => Department of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/09/Zebrafish.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => ABE, Gembu (阿部玄武) [researchers_position_2] => Department of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku University, Japan [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/09/Zebrafish-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Gembu-Abe [researchers_second_profile_2] => https://orcid.org/0000-0002-9905-8506 ) [original_article_reference] => [research_footprints] => danio rerio; limb development; standard length; polymerase chain reaction; phenotypic variation; fin ray; zone of polarizing activity; apical ectodermal ridge [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/09/Zebrafish-6.png [video] => [the_novelty] =>

This study showed that the connections between fin rays and distal radials influence patterns exhibited by zebrafish's pectoral fin rays along the antero-posterior (AP) axis. Through detailed morphological observation, it was noted that the formation of the pattern relied on the developmental genes for AP patterning in the limb/fin bud. Such developmental mechanisms were similar to those of the distal element of the limb skeleton. The reported topological relationships and development processes serve as valuable literature to facilitate studies related to the skeletal patterns of fish.

[the_background] =>

Fin rays are rod-like support of the fin membrane. They are often observed in various fish and are attached to the distal radials to exhibit patterns. However, there were limited reports on pattern formation. Furthermore, the topological relationships, as well as the developmental process between the fin rays and distal radials, were ambiguous. This study intended to investigate the topological relationships, which are the structural organizations, and developmental mechanisms in forming patterns of fin rays along the antero-posterior axis. The findings also showed how different parts of zebrafish are closely related in the development to form important structures for supporting daily activities.

[the_sdg_impact] =>

Morphological studies contribute to a range of implications, be it to deepen the understanding of the biological evolution of organisms or design development of infrastructure. The techniques used in this study do not just provide deeper insights into the structures of zebrafish's fin ray and distal radials; instead, the findings could potentially be useful to marine researchers interested in exploring similar structures of other aquatic creatures. Directly and indirectly, such understanding could provide better solutions in sustaining marine resources (UN SDG 14: Life below water). Moreover, understanding fin design and development is crucial in diversifying hydrodynamics-related experiments and features needed to build resilient infrastructure and foster innovation (UN SDG 9: Industry, innovation, and infrastructure).

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0145-z [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/09/Zebrafish3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/09/Zebrafish_9765202_1631845264.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0145-z [original_article_reference_fields] => Array ( [publication_title] => Pattern of fin rays along the antero-posterior axis based on their connection to distal radials [journal_title] => Zoological Letters [publisher] => BMC [year] => September 2019 [subject] => ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [112] => WP_Post Object ( [ID] => 30207 [post_author] => 154 [post_date] => 2021-09-07 09:28:18 [post_date_gmt] => 2021-09-07 01:28:18 [post_content] => [post_title] => Rare and Extraordinary Structural Characteristics of the Common Freshwater Moss Animal - Stephanella Hina [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => rare-and-extraordinary-structural-characteristics-of-the-common-freshwater-moss-animal-stephanella-hina [to_ping] => [pinged] => [post_modified] => 2022-03-08 16:17:31 [post_modified_gmt] => 2022-03-08 08:17:31 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=30207 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HIROSE, Masato (広瀬雅人) [researchers_position] => School of Marine Biosciences, Kitasato University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/09/bryozoan-5-1.png [researchers_profile] => https://www.researchgate.net/profile/Masato-Hirose [researchers_second_profile] => https://orcid.org/0000-0001-9991-7238 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => morphology; scanning microscopy; Stephanellidae; laser scanning; Epistome; sister group [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/09/bryozoan.png [video] => [the_novelty] =>

The study found that the general structural characteristics between Stephanella hina and other freshwater bryozoans (moss animals) were not too different. However, Stephanella hina did possess distinct cladistic traits, separating it from the rest of the freshwater bryozoans. The most distinctive feature of Stephanella hina, according to the in-vivo analysis, is their lophophore structure and neuromuscular intricacies, differing from other Phylactolaemate bryozoans. However, it remains unclear if these differences are biologically classified as non-ancestral (apomorphic) or ancestrally shared (plesiomorphic), suggesting a potential future expansion.

[the_background] =>

This research describes features that differentiate Stephanella hina from other Phylactolaemate bryozoans. Bryozoa are essentially a category or phylum comprising aquatic colonies that are especially diverse in marine areas. Phylactolaemata is a division within Bryozoa that describes colonies native to freshwater, such as Stephanella hina. There has not been much detailed research conducted on Stephanella hina to properly understand the structural characteristics of this species. Therefore this study performed a thorough in-vivo analysis to fulfill the research gap. This study suggests an analysis of the family Lophopodidae, the early branch in Phylactolaemate bryozoans, to truly understand if the differences found were ancestral (plesiomorphic) or non-ancestral (apomorphic).

[the_sdg_impact] =>

A quick observation of Stephanella hina distribution through NatureServe Explorer (see: https://explorer.natureserve.org/Taxon/ELEMENT_GLOBAL.2.119240/Stephanella_hina) will reveal that much about the species is a mystery aside from generic taxonomic information. Since the Phylactolaemate bryozoans are the early branch of the phylum Bryozoa, describing and understanding the structural characteristics of this group, as such, findings from this research would also contribute to increased scientific knowledge per Sustainable Developmental Goal 14.A to further advance marine health. Understanding the differences between Stephanella hina and other Phylactolaemate bryozoans allows effective enactment of SDG 14.5 to conserve at least 10 percent of coastal and marine areas based on reliable scientific information through means that complement the differences. Understanding the origin of these differences is crucial to determine if the differences are plesiomorphic or apomorphic to further enhance scientific and conservation efforts.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-00165-5 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/09/bryozoan-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/09/bryozoan_9489783_1630976856.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-020-00165-5 [original_article_reference_fields] => Array ( [publication_title] => Morphology of Stephanella hina (Bryozoa, Phylactolaemata): common phylactolaemate and unexpected, unique characters [journal_title] => Zoological Letters [publisher] => BMC [year] => November 2020 [subject] => Zoology; Marine Biosciences ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [113] => WP_Post Object ( [ID] => 30187 [post_author] => 154 [post_date] => 2021-09-06 21:39:48 [post_date_gmt] => 2021-09-06 13:39:48 [post_content] => [post_title] => Higher Efficiency Targeted Gene Integration in Medaka [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => higher-efficiency-targeted-gene-integration-in-medaka [to_ping] => [pinged] => [post_modified] => 2022-02-03 13:34:41 [post_modified_gmt] => 2022-02-03 05:34:41 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=30187 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KINOSHITA, Masato (木下政人) [researchers_position] => Graduate Schools Agriculture, Kyoto University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/09/medaka-.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0003-3936-7371 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Homology-directed repair; Medaka; microhomology-mediated end joining; sodium dodecyl sulfate; central nervous system; mutagenesis; bacterial artificial chromosome; homologous recombination; clustered regularly interspaced short palindromic repeats; transcription activator; genome editing; oryzias; non-homologous end-joining [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/09/medaka-5.png [video] => [the_novelty] =>

The CRISPR/Cas is a tool known for its targeted gene integration, yet there is room for overall efficiency enhancement. This study demonstrated that targeted gene integration events could be induced more efficiently using donor plasmids with longer homology arms than those with shorter homology arms. Besides that, linearization of circular donor plasmids and utilization of suitable bait sequences also increased the efficiency. The targeted gene integration events were attempted using CRISPR/Cas system and donor plasmids with homologous sequences in medaka (Oryzias latipes). The results implied that its efficiency was possible to be further increased via suitable techniques.

[the_background] =>

The CRISPR/Cas system is a powerful genome-editing tool. Despite being well-known for its potential, the number of reports on targeted gene integration using the CRISPR/Cas system was scarce. This implied the availability of room for optimization on the performance of this system. Therefore, via in vivo and in silico experiments, this study attempted to enhance the efficiency of targeted gene integration events in medaka. Such effort paves a path for related future research to be carried out more effectively using similar methods in other fish species.

[the_sdg_impact] =>

Gene-editing technology is capable of re-designing the genome of organisms and plants. Imperfections, such as inherited illness, are possible to be eliminated in the offsprings through this technology. Meanwhile, the techniques to increase the efficiency of the CRISPR/Cas system create higher possibilities to achieve better results in gene editing. By introducing these techniques, the outcome of this study is able to facilitate future studies which adopt the CRISPR/Cas system. Hence, this research is well-aligned with UNSDG 9: Industry, Innovation & Infrastructure by enhancing scientific research.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-017-0071-x [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/09/medaka-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/09/medaka_9477468_1630935099.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-017-0071-x [original_article_reference_fields] => Array ( [publication_title] => An efficient system for homology-dependent targeted gene integration in medaka (Oryzias latipes) [journal_title] => Zoological Letters [publisher] => BMC [year] => July 2017 [subject] => Zoology; Agriculture ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [114] => WP_Post Object ( [ID] => 29881 [post_author] => 154 [post_date] => 2021-08-25 15:50:02 [post_date_gmt] => 2021-08-25 07:50:02 [post_content] => [post_title] => Cancer-Inducing Ligand-Receptor Pair [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => cancer-inducing-ligand-receptor-pair [to_ping] => [pinged] => [post_modified] => 2022-02-24 11:49:33 [post_modified_gmt] => 2022-02-24 03:49:33 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29881 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/r1-1.png [researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung [researchers_second_profile] => https://orcid.org/0000-0003-4317-4740 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => ligand-binding domain; breast cancer; tyrosine kinase; lymph node; western blotting; extracellular domain; horseradish peroxidase; tissue microarray; standard deviation; American Type Culture Collection; phosphate-buffered saline; epidermal growth factor receptor; proximity ligation assay; ephrin a4; hepatocyte growth factor receptor; E. coli; small hairpin RNA; receptor tyrosine kinase [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/ribonuclease-4.png [video] => [the_novelty] =>

This study disclosed a ligand-receptor relationship that played a significant role in initiating the growth of breast tumors. Human antibody array studies identified hRNase1 as a ligand for EphA4 and that the hRNase 1-mediated EphA4 signaling led to breast cancer development. Moreover, the impact of RNase 1–EphA4 ligand-receptor relationship was consistent with those of hRNase 5–EGFR and hRNase 7–ROS1 in promoting tumor growth. Therefore, further studies focusing on RNase–RTK targeted inhibition would contribute to new therapeutic strategies for various cancers.

[the_background] =>

Despite the extensive studies on the biochemical properties of hRNase 1, the actual biological function of hRNase 1 has yet to be determined. Meanwhile, the ligand-receptor relationships of hRNase 5–EGFR and hRNase 7–ROS1 were proven to result in tumor growth. Based on those findings, there are reasons to believe that hRNase 1 has similar involvement in cancers. On the other hand, the upregulation of receptor EphA4 in breast cancer stem-like cells (CSCs) indicates the possibility of treating cancer via EphA4 inhibition. Thus, this study investigated the implication of the hRNase 1–EphA4 ligand-receptor relationship in breast cancers. Identifying the critical role of the hRNase 1–EphA4 pair in breast cancer initiation implied that the initiation of other cancers could be due to similar ligand-receptor relationships. Thus, setting a clear study scope for future anti-tumor research.

[the_sdg_impact] =>

In 2020, 2.3 million women were diagnosed with breast cancer globally. This suggests that there is an urgent need for the development of more promising therapies to treat breast cancer. Along with the findings derived from the studies of hRNase 5–EGFR and of hRNase 7–ROS1 pairs, this study established a firm validation associating RNase–RTK pairs to the root cause of cancers. By identifying the possible pathways for cancers, this study expands the possibility of deriving potentially effective cancer interventions in the near future (UNSDG 3: Good Health & Well-Being).

[article_url] => https://www.nature.com/articles/s41467-021-23075-2 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/ribonuclease-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/ribonuclease_9168571_1629877146.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41467-021-23075-2 [original_article_reference_fields] => Array ( [publication_title] => Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation [journal_title] => Nature Communications [publisher] => Springer Nature [year] => May 2021 [subject] => Medical; Biomedical Sciences; Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/aai1oq_pjUg [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/08/The-Initiator-of-Breast-Cancer.mp4_snapshot_00.00_2021.11.08_13.42.12.png ) ) [115] => WP_Post Object ( [ID] => 29622 [post_author] => 154 [post_date] => 2021-08-19 11:56:26 [post_date_gmt] => 2021-08-19 03:56:26 [post_content] => [post_title] => Tannic Acid as Dual-Action Remedy for COVID-19 [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => tannic-acid-as-dual-action-remedy-for-covid-19 [to_ping] => [pinged] => [post_modified] => 2022-02-24 12:04:14 [post_modified_gmt] => 2022-02-24 04:04:14 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29622 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/r1-1.png [researchers_profile] => https://www.researchgate.net/profile/Mien_Chie_Hung [researchers_second_profile] => https://orcid.org/0000-0003-4317-4740 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => COVID-19; prostate cancer; TMPRSS2; SARS-CoV-2; serine protease; tannic acid; surface plasmon resonance; severe acute respiratory syndrome [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/Tannic-4-.jpg [video] => [the_novelty] =>

This study identified the potential of tannic acid (a compound found in fruits and plants) as a natural remedy for COVID-19. Results from in vitro experiments showed that tannic acid was able to inhibit the activity of coronavirus SARS-CoV-2’s main protease. Furthermore, tannic acid also prevented the entry of SARS-CoV-2 into cells by inhibiting the human cell surface protease TMPRSS2. By acting as an effective dual inhibitor of the two main proteases involved in coronavirus SARS-CoV-2 infection, the clinical trial of tannic acid in treating COVID-19 is highly anticipated. Meanwhile, since TMPRSS2 is also responsible for prostate cancer progression, future studies can be conducted to examine the potential of tannic acid in suppressing cancer progression through TMRPSS2 inhibition.

[the_background] =>

From the perspective of biological science, the COVID-19 pandemic can be overcome by deactivating the main protease of coronavirus SARS-CoV-2 and blocking the entry of SARS-CoV-2 into human cells. But, how? In order to prevent the cellular entry of SARS-CoV-2, human cell surface protease TMPRSS2 should be targeted as it was reported to form an ‘entrance’ for such invasion. Various natural compounds from fruits and plants exhibited anti-coronavirus properties. Hence, this study was carried out to determine the potential of tannic acid (a natural compound) in suppressing SARS-CoV-2. The outcome showed that tannic acid was able to deactivate the main protease of coronavirus SARS-CoV-2 and also managed to block the cellular entry of SARS-CoV-2 via inhibition of protease TMPRSS2. The dual action of tannic acid indicated its high potential in battling COVID-19.

[the_sdg_impact] =>

To date, scientists are still working towards effective remedies to deal with COVID-19 while the global death toll rises. Although numerous vaccination programs have been rolled out globally, the frequent mutation rate to generate viral variants of SARS-CoV-2 has raised the necessity to develop anti-Covid-19 drugs. Therefore, a possible treatment with minimal side-effect is needed as soon as possible. The discovery of tannic acid’s potential as a low-risk yet feasible compound for treating COVID-19 could inspire more magnificent research in a similar direction. Thus, by achieving significant milestones in the research and development of vaccines and medicines for COVID-19, this study contributes to the realization of UNSDG 3: Good Health & Well-being.

[article_url] => https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783773/ [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/Tannic-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/Tannic_8893553_1629010749.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => [original_article_reference_fields] => Array ( [publication_title] => Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease [journal_title] => American Journal of Cancer Research [publisher] => e-Century Publishing Corporation [year] => December 2020 [subject] => Medical; Covid-19 ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/mQyjDXhQ_8o [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/08/13-14.mp4_snapshot_00.01_2021.10.20_10.04.37.png ) ) [116] => WP_Post Object ( [ID] => 29605 [post_author] => 154 [post_date] => 2021-08-19 11:53:17 [post_date_gmt] => 2021-08-19 03:53:17 [post_content] => [post_title] => How Do Antioxidant Components in Blueberries Conduct Whitening Activities in Skin Cells and Animals? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => how-do-antioxidant-components-in-blueberries-conduct-whitening-activities-in-skin-ccells-and-animals [to_ping] => [pinged] => [post_modified] => 2022-02-24 11:59:33 [post_modified_gmt] => 2022-02-24 03:59:33 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29605 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HSEU, You-Cheng (許游章) [researchers_position] => Department of Cosmeceutics, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/you.png [researchers_profile] => https://orcid.org/0000-0001-5307-6162 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => melanocortin 1 receptor; bovine serum albumin; acridine orange; pterostilbene; fetal bovine serum fluorescein isothiocyanate; cAMP response element-binding protein; keratinocyte; dimethyl sulfoxide; Nrf2; reactive oxygen species; polyvinylidene difluoride; autophagy; protein kinase A; microphthalmia-associated transcription factor [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/08/antioxidant-4.jpg [figures] => [video] => [the_novelty] =>

This novel study revealed the whitening activities of an antioxidant component in blueberries (Pterostilbene) in cells and animals. This was achieved by triggering the melanin cell autophagy mechanism (self-eating) and disabling UV (Ultraviolet)-damaged hormones in keratinocytes through an antioxidant pathway. The findings showed that Pterostilbene activated the Nrf2 antioxidant gene in keratinocytes, stimulating the HO-1 and γ-GCLC antioxidant enzymes. It also increased the autophagy-associated proteins, LC3-II and p62, while simultaneously decreasing the ATG4B protein in melanocytes. Thus, the cells produced their own antioxidants, leading to the inhibition of melanin production. This study can further expand by researching the mechanism involved in Pterostilbene interfering with the melanosome maturation process to better understand its whitening properties.

[the_background] =>

UV radiation such as UV-A and UV-B rays can penetrate the skin and increase melanin production, causing dark skin spots. Chinese herbal medicine has 13 approved whitening ingredients, which mainly inhibit melanin production and pigmentation. One such ingredient is Resveratrol. Unfortunately, most commercially available sunscreens are not able to resist UV-A rays. However, Pterostilbene is seen as a powerful natural antioxidant that can be applied onto the skin to achieve the whitening effect. Previous studies reported cell autophagy and deactivation of hormones in skin cells aid in Pterostilbene’s whitening effects in various cells and lab animals. However, this is one of the first studies to explain the molecular processes of Pterostilbene’s whitening effects in keratinocytes and melanocytes. In addition, the study uses Zebrafish embryos to prove Pterostilbene’s effectiveness as a whitening component in skin-whitening agents.

[the_sdg_impact] =>

According to past literature, it was found that the UV radiation in China decreased from 1961 to 1991. However, there seems to be an increase in UV radiation from 1991 to 2012. Similar could be observed with other parts of the world. With increasing UV radiation, more UV-A rays can penetrate the skin and trigger the melanocytes to increase melanin production, leading to dark spot formation on the skin. This can cause frustration and emotional stress in an individual. More research needs to be conducted to identify an effective whitening component to ensure that people can successfully treat these dark skin spots. The aim of this study is aligned with the “Goal 3: Good Health and Well-Being” of the UN’s Sustainable Development Goals. This research could allow the use of Pterostilbene in treating skin diseases caused by UV-A rays.

[article_url] => https://www.sciencedirect.com/science/article/pii/S2213231721001658?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/antioxidant-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/antioxidant_8893294_1629009543.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.redox.2021.102007 [original_article_reference_fields] => Array ( [publication_title] => The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated α-MSH in keratinocytes via Nrf2-mediated antioxidant pathways [journal_title] => Redox Biology [publisher] => Elsevier [year] => August 2021 [subject] => Medical; Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/bPULxXzW3Ss [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/08/11.mp4_snapshot_00.01_2021.10.20_10.15.04.png ) ) [117] => WP_Post Object ( [ID] => 29588 [post_author] => 154 [post_date] => 2021-08-19 11:47:53 [post_date_gmt] => 2021-08-19 03:47:53 [post_content] => [post_title] => TYRO3: The Reason Behind Anti–PD-1/PD-L1 Immunotherapy Resistance in Cancer Treatment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => tyro3-the-reason-behind-anti-pd-1-pd-l1-immunotherapy-resistance-in-cancer-treatment [to_ping] => [pinged] => [post_modified] => 2022-02-24 11:53:24 [post_modified_gmt] => 2022-02-24 03:53:24 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29588 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/r1-1.png [researchers_profile] => https://www.researchgate.net/profile/Mien_Chie_Hung [researchers_second_profile] => https://orcid.org/0000-0003-4317-4740 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => gene expression omnibus; triple-negative breast cancer; damage-associated molecular pattern; t cell; arginase 1; immune checkpoint blockade; thiobarbituric acid; tumor cell; triple-negative breast; cancer; ferritin light chain; ferroptosis; tumor microenvironment; therapeutic target [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/08/immunotherapy-4.jpg [figures] => [video] => [the_novelty] =>

This study is a novel attempt to investigate receptor tyrosine kinase (RTKs) that could potentially contribute to the resistance of anti-programmed cell death protein 1/ programmed death-ligand 1 (anti- PD-1/ PD-L1) therapy in cancer. The outcome showed a significant association between tyrosine receptor kinase protein 3 (TYRO3) and anti-PD-1/ PD-L1 therapy resistance in different tumors. A series of comprehensive research designs, cellular (in-vitro), animal (in-vivo), and retrospective computer (in-silico) analysis on multiple databases, revealed that the high expression and phosphorylation status of TYRO3 correlates to poorer prognosis in anti- PD-1/ PD-L1 treatment and causes resistance. Furthermore, TYRO3 was also found to be suppressing ferroptosis, a nonapoptotic, iron-dependent form of cell death via the AKT/ NFR2 pathway, thus diminishing the sensitivity of cancer cells to anti- PD-1/ PD-L1 treatment. Overall, the study implicates the protein's role as a potential biomarker for patient stratification and therapeutic options.

[the_background] =>

Immunotherapy that involves blockade of PD-1/ PD-L1 has been clinically gaining interest in cancer treatment due to its anti-tumor potential. Nevertheless, the response rate of PD-1/PD-L1 antagonism as a single therapy in cancer treatment has been relatively low owing to resistance to the therapy and insufficient biomarkers to select patients for treatment. Although there has been emerging evidence of the TAM (TYRO3, AXL, and MerTK) family's role in host immune response, this study proved that TYRO3 participates in eliciting resistance in anti- PD-1/ PD-L1 treatment, and not AXL or MerTK. Following the recent success of RTK inhibitors in cancer treatment, the findings can potentially pave ways to develop therapeutic targets on TYRO3. Considering the structural similarity of TYRO3 to AXL and MerTK, more in-vivo studies should be done in the future to confirm the specificity of the protein's role in contributing to treatment resistance. The study must also be duplicated in different malignancies to understand the protein's universal function and therapeutic efficacy in other tumors.

[the_sdg_impact] =>

Global oncology spending has steadily increased from USD 56 billion to USD 187 billion from 2011 to 2021, close to a four-fold increase in just a decade (Statista). The economic toll is approximately 19% higher than heart disease, the second leading cause of economic loss following cancer (American Cancer Society). These staggering figures are continuous reminders of the urgent need for targeted therapies and biomarkers in improving the efficacy of cancer treatment. This study builds on the evidence and contributes towards the potential development of RTK inhibitor therapy and biomarkers in different cancers. Thus, it helps realize the United Nation's Sustainable Development Goal, UNSDG 3: Good health and well-being, by contributing to developing therapeutics for a disease that enormously costs the global economy and quality of life.

[article_url] => https://www.jci.org/articles/view/139434 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/immunotherapy-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/immunotherapy_8893113_1629008444.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1172/JCI139434 [original_article_reference_fields] => Array ( [publication_title] => TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis [journal_title] => The Journal of Clinical Investigation [publisher] => American Society for Clinical Investigation [year] => April 2021 [subject] => Medical, Cancer; Immunotherapy ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/UX38WDGgFks [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/08/RTK-inhibitor-improves-anti–PD-1-PD-L1-immunotherapy-in-cancer.mp4_snapshot_00.01_2021.11.08_13.42.21.png ) ) [118] => WP_Post Object ( [ID] => 29571 [post_author] => 154 [post_date] => 2021-08-19 11:44:05 [post_date_gmt] => 2021-08-19 03:44:05 [post_content] => [post_title] => TET2 Regulates the Development of Breast Tumor and Response to Anti-estrogen Treatment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => tet2-regulates-the-development-of-breast-tumor-and-response-to-anti-estrogen-treatment [to_ping] => [pinged] => [post_modified] => 2022-02-24 11:51:29 [post_modified_gmt] => 2022-02-24 03:51:29 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29571 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YANG, Jer-Yen (楊哲彥) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/jyyang.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0003-2789-8888 (Jer-Yen Yang) ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => chromatin immunoprecipitation; Cytokeratin 14; mammary gland development; long terminal repeat; ;epigenetic regulation; terminal end bud; Cytokeratin 8; cell fate [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/TET2-4.png [video] => [the_novelty] =>

This study emphasizes the role of TET2 in breast cancer development. TET2 is shown to form a complex with transcription factor FOXP1 to mediate the expression of ESR1, GATA3, and FOXA1 genes that are responsible for the development of the mammary gland and response to hormones. Loss of TET2 leads to silenced estrogen receptors (ER) expression, consequently promoting intrinsic resistance to tamoxifen. These findings are of vast clinical significance, elucidating the potential for loss of TET2 expression as a biomarker to predict the resistance to anti-estrogen treatment. Additionally, these findings offer a new avenue of restoring TET2 activity to treat breast cancer patients exhibiting intrinsic resistance to hormone therapy.

[the_background] =>

TET2, a DNA demethylation enzyme, commonly found in the mammary gland, plays a pivotal role in regulating mammary stem cells' (MaSc) homeostasis. MaSC generates progeny cells responsible for the formation of the mammary gland. Past research has very much linked suppression of TET2 to impaired, cancer-like cell division through in-vitro studies. However, little is known of the role of TET2 in regulating MaSC homeostasis and tumor development in-vivo. CMU researchers have found that loss of TET2 expression could result in impaired differentiation from MaSC to the inner cell lining of the mammary gland, leading to the development of aggressive breast cancer using a mouse model. Therefore, findings from this study offer insight into a new role of TET2 in the development of breast cancer and resistance to anti-estrogen treatment.

[the_sdg_impact] =>

The past five years have seen approximately 7.8 million women diagnosed with breast cancer, with a staggering 685 000 deaths reported globally just last year (WHO, 2021). There is an urgent need for early detection, rapid diagnosis, and effective treatment methods considering how breast cancer accounts for the highest prevailing form of cancer. This study offers potential in fulfilling Sustainable Development Goals (SDG) 3.4, calling for reducing one-third of mortality caused by non-communicable diseases like breast cancer. Its findings on the role of TET2 can be regulated favorably to promote response towards tamoxifen. Likewise, it provides the potential for detecting hormone therapy resistance using the loss of TET2 as a biomarker.

[article_url] => https://www.nature.com/articles/s41467-020-18129-w [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/TET2-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/TET2_8892942_1629007480.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41467-020-18129-w [original_article_reference_fields] => Array ( [publication_title] => TET2 directs mammary luminal cell differentiation and endocrine response [journal_title] => Nature Communications [publisher] => Springer Nature [year] => September 2020 [subject] => Medical; Breast Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/GJ76SclrhgM [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/08/07.mp4_snapshot_00.01_2021.10.20_10.13.04.png ) ) [119] => WP_Post Object ( [ID] => 29540 [post_author] => 154 [post_date] => 2021-08-19 11:38:30 [post_date_gmt] => 2021-08-19 03:38:30 [post_content] => [post_title] => Tumor Eradication through nPD-L1-mediated Pyroptosis [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => tumor-eradication-through-npd-l1-mediated-pyroptosis [to_ping] => [pinged] => [post_modified] => 2022-02-24 11:40:31 [post_modified_gmt] => 2022-02-24 03:40:31 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29540 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/r1-1.png [researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung [researchers_second_profile] => https://orcid.org/0000-0003-4317-4740 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => nuclear export signal; chemotherapy drug; clustered regularly interspaced short palindromic repeats; lactate dehydrogenase; nuclear localization signal; apoptosis; macrophage; breast cancer; cancer cell; gasdermin D; tumour; necrosis factor α; chromatin immunoprecipitation [graphic_abstract] => [figures] => [video] => [the_novelty] =>

This research revealed an antibiotics-induced cellular pathway that could effectively kill tumor tissues. The mechanism occurs when the cells are deprived of oxygen, whereby nuclear-programmed death-ligand 1 (nPD-L1) enables pyroptosis (instead of apoptosis) programmed death in cancer cells. Sequentially, it involves interactions between p-Stat3 and nPD-L1, transcription of the gasdermin C (GSDMC) gene, cleavage of GSDMC by caspase-8 (activated by TNFα), and, eventually, death of cancer cell due to pyroptosis. Unlike PD-L1, the role of nPD-L1 in this particular anti-tumor pathway did not involve any checkpoint inhibitor. Further investigation can be conducted to study its feasibility in treating different types of cancer.

[the_background] =>

PD-L1 is usually located in the cell surface and has been a common target for checkpoint inhibition immunotherapy. Meanwhile, little is known of the exact role and purpose of PD-L1 located in the nucleus (i.e., nPD-L1). Compared to apoptosis (a cell’s natural mechanism for programmed death), pyroptosis (an inflammatory programmed cell death) in cancer cells showed more promising results in killing tumor tissues. Upon determining the function of nPD-L1, this research demonstrated nPD-L1’s ability to mediate the switch from apoptosis to pyroptosis, which successfully killed tumor tissues under hypoxia. These significant findings show high potential in the development of a new anti-cancer therapy.

[the_sdg_impact] =>

There are more than 100 types of cancer, which implies humans' high vulnerability towards cancer. Hence, cancer-related studies are essential not only for increasing patients’ survival rates, but also to provide advanced knowledge of the human body, especially the immune system. The new method to kill cancer cells discussed in this study is a valuable effort to support the research and development of cancer treatment (UNSDG 3: Good Health & Well-being).

[article_url] => https://www.nature.com/articles/s41556-020-0575-z [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/pyroptosis.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/pyroptosis_8891276_1628997624.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41556-020-0575-z [original_article_reference_fields] => Array ( [publication_title] => PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis [journal_title] => Nature Cell Biology [publisher] => Springer Nature [year] => September 2020 [subject] => Medical; Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/5NBNN5nYUDA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/08/02.mp4_snapshot_00.01_2022.02.24_11.39.21.jpg ) ) [120] => WP_Post Object ( [ID] => 29554 [post_author] => 154 [post_date] => 2021-08-19 11:08:26 [post_date_gmt] => 2021-08-19 03:08:26 [post_content] => [post_title] => Antitumor Pathway Involving Galectin 9, PD-1 and TIM-3 [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => antitumor-pathway-involving-galectin-9-pd-1-and-tim-3 [to_ping] => [pinged] => [post_modified] => 2022-02-24 11:47:40 [post_modified_gmt] => 2022-02-24 03:47:40 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29554 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/r1-1.png [researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung [researchers_second_profile] => https://orcid.org/0000-0003-4317-4740 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => extracellular domain; T helper; E. coli; tumor necrosis factor receptor superfamily; antigen-presenting cells; fetal bovine serum; treg cell; immunotherapy; dendritic cells; cell death; tumor microenvironment galectin; The Cancer Genome Atlas; immune response; cancer immunotherapy; room temperature; immune checkpoint; antibody-dependent cell-mediated cytotoxicity; phosphate-buffered saline [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/Antitumor-4.png [video] => [the_novelty] =>

This study identified a molecular mechanism responsible for promoting the survival of exhausted T-cells, which resulted in higher antitumor activity. Apart from its commonly known functions, programmed cell death protein 1 (PD-1) was able to inhibit the induced death of exhausted T-cells by binding to galectin-9 ligand (Gal-9). While letting the exhausted T-cells sustain their role in immunity, the inhibition of Gal-9 could also be a high-potential antitumor therapy, as indicated by in vitro studies. Thus, further investigations emphasizing anti-Gal-9-based cancer therapy are very likely to lead to the development of various therapies for treating a broader spectrum of cancer.

[the_background] =>

T cells exhaustion occurs during chronic infections and cancer, whereby the optimal control of infection and tumors is prevented. The two T cell inhibitory receptors PD-1 and TIM-3 (T-cell immunoglobulin and mucin domain-3) are co-expressed in this state. Consequently, the binding of Gal-9 to TIM-3 will induce natural programmed death of T cells, resulting in lower immunity. However, in the tumor microenvironment (TME), the exhausted T-cells persist instead. Hence, this study was conducted with interest to verify the speculation stating that the persistence was due to the inhibition of Gal-9/TIM-3 by PD-1. Other than the successful verification, its conclusion also highlighted that Gal-9 was a crucial target for immunotherapy. This forms a robust foundation for future studies related to immunotherapy.

[the_sdg_impact] =>

Being known as the second leading cause of death, cancer has been studied extensively for decades with the sole purpose of ending it ultimately. Therefore, scientists have persevered in exploring the most feasible therapies from various biological aspects to address the entire spectrum of human malignancies. With richer knowledge of T-cells, the outcome of this study has established a new research direction for immunotherapy. The contributions of this study are well-aligned with UNSDG 3: Good Health & Well-being.

[article_url] => https://www.nature.com/articles/s41467-021-21099-2 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/Antitumor-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/Antitumor_8891961_1629001499.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41467-021-21099-2 [original_article_reference_fields] => Array ( [publication_title] => Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy [journal_title] => Nature Communications [publisher] => Springer Nature [year] => February 2021 [subject] => Medical; Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/CcKwwAOS9sE [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/08/05.mp4_snapshot_00.01_2021.10.20_10.11.12.png ) ) [121] => WP_Post Object ( [ID] => 29523 [post_author] => 154 [post_date] => 2021-08-19 11:02:05 [post_date_gmt] => 2021-08-19 03:02:05 [post_content] => [post_title] => Treating Liver Cancer by Inhibiting ROS1 Oncogene [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => treating-liver-cancer-by-inhibiting-ros1-oncogene [to_ping] => [pinged] => [post_modified] => 2022-02-24 11:35:22 [post_modified_gmt] => 2022-02-24 03:35:22 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29523 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/r1-1.png [researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung [researchers_second_profile] => https://orcid.org/0000-0003-4317-4740 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => ROS1; ribonuclease 7; plasma biomarker; hepatocellular carcinoma; crizotinib; cancer; ttyrosine kinase; signaling; treatment stratification; liver cancer [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/08/ROS1-4.jpg [figures] => [video] => [the_novelty] =>

By identifying recombinant ribonuclease RNase7 as the ligand which activates receptor tyrosine kinase ROS1, this study introduces a potential treatment for hepatocellular carcinoma (HCC). As a result of ligand-receptor relationship establishment between RNase7 and ROS1 based on both in vitro and in vivo studies, the ROS1 pathway involved in tumor growth was inhibited. Thus, the mechanism promises a potential treatment for patients with high RNase7 expression. With that said, clinical trials should be conducted to better understand the effectiveness of RNase7-ROS1 targeted therapy in treating liver cancer and other cancers.

[the_background] =>

Cell surface receptor ROS1 is involved in the formation of tumor cells. Therefore, ROS1 is often part of the main subject in studies related to human cancers. However, the ligand responsible for the activation of the ROS1 pathway is still unknown. Thus, such a gap in knowledge poses a major hurdle in developing effective targeted therapy for HCC. With reference to recent studies indicating RNase as a possible ligand for ROS1, this study successfully demonstrates RNase7 as the ligand of interest and that anti-ROS1 inhibition could potentially be used to treat HCC. Hence, serving as a significant milestone that brings oncology closer to discovering more effective cancer prevention and cure.

[the_sdg_impact] =>

The number of death due to cancer in 2018 has reached 9.6 million worldwide, making this disease the second leading cause of death globally. In other words, countless lives can be saved if feasible cancer treatments are developed and made accessible to all cancer patients. The discovery of the ROS-1 inhibition mechanism and its relationship with tumor growth provides great insights into potential HCC treatment. Such progress aligns with the objectives of UNSDG 3: Good health & well-being by propelling cancer treatment research development forward.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0168827820336746 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/ROS1-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/ROS1_8891028_1628996658.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.jhep.2020.09.030 [original_article_reference_fields] => Array ( [publication_title] => Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma [journal_title] => Journal of Hepatology [publisher] => Elsevier [year] => April 2021 [subject] => Medical; Cancer ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Z5Qc5_Oy48k [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/08/01.mp4_snapshot_00.01_2021.10.20_10.08.13.png ) ) [122] => WP_Post Object ( [ID] => 29412 [post_author] => 154 [post_date] => 2021-08-12 17:52:54 [post_date_gmt] => 2021-08-12 09:52:54 [post_content] => [post_title] => Review on Production and Quality Requirements of Human Platelet Lysate (HPL) [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => review-on-production-and-quality-requirements-of-human-platelet-lysate-hpl [to_ping] => [pinged] => [post_modified] => 2021-11-08 11:02:38 [post_modified_gmt] => 2021-11-08 03:02:38 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29412 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => BURNOUF, Thierry [researchers_position] => College of Biomedical Engineering, Taipei Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/f3.png [researchers_profile] => https://www.researchgate.net/profile/Thierry-Burnouf [researchers_second_profile] => https://orcid.org/0000-0002-0507-9243 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => west nile virus; human leukocyte antigens; hepatitis B virus; stromal cell; creutzfeldt–jakob disease; babesia microti; fetal bovine serum; blood transfusion; platelet concentrate; zika virus; medicinal product; transmissible spongiform encephalopathies; mesenchymal stromal cells; growth factor; extracellular vesicles; hepatitis E virus; mesenchymal stem cell; hepatitis C virus; dengue virus; human cell; platelet lysate; bovine spongiform encephalopathy [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/Platelet-4.png [video] => [the_novelty] =>

Human platelet lysate (HPL) has been extensively explored for cell therapy and regenerative medicine as a suitable and effective substitute for fetal bovine serum (FBS). Hence, an internationally standardized quality control protocol is needed to manage the production, safety, and quality criteria. As an attempt, this study evaluated existing literature on HPL production and outlined necessary guiding steps to ensure the maximal safety of this ancillary material. It emphasized that there should be an evaluation at all stages, including blood donation, production of HPL, and risk assessment of viral safety. Above all, HPL manufacturers should ensure the quality of PC used in their production, and the HPL manufacturing facilities should meet the standards set by the Good Manufacturing Practice (GMP) protocols.

[the_background] =>

Until recently, FBS has been the go-to supplement medium for external experimentation to propagate stromal cell-based medicinal products. However, due to its animal-based origins, there are concerns about the immunological and infectious safety of FBS’s use in cell therapy and regenerative medicine. Given such circumstances, HPL is now emerging as the most viable alternative to FBS as it alleviates this concern. HPL-medium also proved to provide better cell expansion with a shorter doubling time in the expansion of mesenchymal stromal cells (MSCs) from various tissues compared to an FBS-medium and does not stimulate tumorigenicity in vivo. Therefore, the role of HPL in biotechnology and cell therapy is predicted to expand. With that, the need for a consensus on quality and safety criteria is crucial. This study reviews and highlights specific measures proposed to achieve this consensus.

[the_sdg_impact] =>

There have been growing concerns about FBS use in cell culture media, largely due to the biosafety aspect, the global demand, and an ethical standpoint. The FBS market is loosely regulated, and many cases of fraud have occurred. In 2015, GE Healthcare teamed up with a New Zealand-based company to detect the origin countries of FBS. This is crucial as different countries of origin pose different viral risks. Based on UNSDG 9: Industries, Innovation, and Infrastructure, which aims to promote economic growth through innovation, infrastructure, and industrialization, HPL provides an innovative alternative to FBS. It also appears to be more efficient when used in cell expansion comparatively, improving the production of stromal cell-based medicinal products. FBS depends on many factors that can reduce its production; hence, according to UNSDG 12: Responsible Consumption and Production, HPL is a better alternative as its supply is more sustainable in the long term, and it avoids the wastage of precious human blood resources.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0167779919301519 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/Platelet-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/Platelet_8821591_1628761509.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.tibtech.2019.06.002 [original_article_reference_fields] => Array ( [publication_title] => Production and Quality Requirements of Human Platelet Lysate: A Position Statement from the Working Party on Cellular Therapies of the International Society of Blood Transfusion [journal_title] => Trends in Biotechnology [publisher] => Elsevier [year] => January 2020 [subject] => Medical; Biotechnology; Biomedical Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [123] => WP_Post Object ( [ID] => 29383 [post_author] => 154 [post_date] => 2021-08-12 14:40:10 [post_date_gmt] => 2021-08-12 06:40:10 [post_content] => [post_title] => An Indigenous Tribe’s Attempt to Reinstate Sustainable Development and Adaptation to Climate Change [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => an-indigenous-tribes-attempt-to-reinstate-sustainable-development-and-adaptation-to-climate-change [to_ping] => [pinged] => [post_modified] => 2021-11-08 11:02:38 [post_modified_gmt] => 2021-11-08 03:02:38 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29383 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LIN, Yih-Ren (林益仁) [researchers_position] => Graduate Institute of Humanities in Medicine, Taipei Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/Indigenous-.png [researchers_profile] => https://www.researchgate.net/profile/Yih-Ren-Lin [researchers_second_profile] => https://orcid.org/0000-0002-4975-7296 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Alnus formosana; climate change; sustainability; adaptation; resilience; climate action [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/Indigenous-5.png [video] => [the_novelty] =>

Western epistemology has always been an integral part of modern society and constantly shapes the deeply-rooted ideology within the global community. Consequently, we have been dismissing the dissemination of knowledge based on different cultural and language entities, especially those of the indigenous people. Hence, this study reinstitutes an alternative mindset by pivoting on the “Millet Ark” initiative, a Tayal community’s millet biodiversity conservative endeavor that effortlessly connects the community, nature, and culture. This “indigeneity retrieval” effort began in 2013 and initiated the realization of the grassroot network involving two of the authors (Pagung and Yih-Ren Lin) and a few members of Taiwan indigenous people and mountain farmers from nine other countries in Bhutan through walking workshops. Inspired and influenced by this experience, Pagung decided to revive long-left millet cultivation in her village. The study assimilated the spirit of the indigenous community, wherein most of the findings were derived using the walking and storytelling culture of indigenous people. The success of Pagung in reinstating Tayal millets in the past five years is evident from the growth of the project from one plot of land to a remarkable landscape of the village, and the millet conservation movement is only continuing to expand by the day.

[the_background] =>

The main aspiration of this study is to revive the values and practices of the indigenous community of Taiwan, particularly the Tayal ethnic group, via exploring the indigenous resilience, which is so brilliantly elucidated via the “Millet Ark” conservation narration. Indigenous resilience is defined as a dynamic process of cultural and ecological adaptation and alteration in response to climate change that is imperative in ensuring the survival of human and non-human species without losing the ethos of a culture. The main limitation in the study is the possible loss of essence that happens in translating indigenous stories or songs into English or Chinese. To retain the gist of the native stories, the authors tried their best to translate the ideas instead of words and accepted a certain level of untranslatability as the power of the alternative ideology that challenges mainstream which is the very purpose of this study. This study is so uniquely crucial as it is proof that the indigenous practice like Tayal millet foodscape sustained the bio- and cultural diversity, enhanced human-nature connection, and fostered complex adaptive system thinking, which is all we need in facing the climate change issue.

[the_sdg_impact] =>

An undeniable but relegated truth is that the indigenous people are among the first to face the consequences of climate change due to their co-dependence on nature. The severity of this issue was proven when the special theme of the 7th session of the United Nations Permanent Forum on Indigenous Issue (New York, 2008) was “Climate change, bio-cultural diversity, and livelihoods: the stewardship role of indigenous peoples and new challenges.” Consistent efforts are needed to mitigate the continuous repercussions faced by the indigenous community in the face of climate change, which is why this study sets a precedent in this matter. Thus, this effort upholds not just one but three vital United Nations Sustainable Development Goals (UNSDG); Goal 13: Climate action, Goal 15: Life on land, and Goal 17: Partnership.

[article_url] => https://www.mdpi.com/2071-1050/12/24/10676 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/Indigenous-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/Indigenous_8817110_1628749945.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.3390/su122410676 [original_article_reference_fields] => Array ( [publication_title] => Situating Indigenous Resilience: Climate Change and Tayal’s “Millet Ark” Action in Taiwan [journal_title] => Sustainability [publisher] => MDPI [year] => December 2020 [subject] => Humanities; Biomedical Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [124] => WP_Post Object ( [ID] => 29358 [post_author] => 154 [post_date] => 2021-08-08 12:44:24 [post_date_gmt] => 2021-08-08 04:44:24 [post_content] => [post_title] => Unknown Roles of Non-hypophysiotropic Gonadotropin-releasing Hormone Neurons Deciphered [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => unknown-roles-of-non-hypophysiotropic-gonadotropin-releasing-hormone-neurons-deciphered [to_ping] => [pinged] => [post_modified] => 2022-01-10 10:33:53 [post_modified_gmt] => 2022-01-10 02:33:53 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29358 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => OKA, Yoshitaka (岡良隆) [researchers_position] => Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/hypophysiotropic-.png [researchers_profile] => https://www.researchgate.net/profile/Yoshitaka-Oka [researchers_second_profile] => https://orcid.org/0000-0002-3482-3051 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => carassius auratus; corticotropin-releasing hormone; neuropeptide; danio rerio; midbrain tegmentum; neuromodulation; wild type; excitatory postsynaptic potential; vertebrate; fonadotropin releasing hormone; trigeminal nerve; terminal nerve; spinal cord [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/hypophysiotropic-5.png [video] => [the_novelty] =>

Non-hypophysiotropic gonadotropin-releasing hormone (GnRH) neurons are commonly found in vertebrates. This review concluded that the non-hypophysiotropic GnRH neurons play an essential role in modulating neural circuits, depending on the internal condition or the external environment. They are involved in regulating major activities, such as behavioral motivation, food intake, and sensory reception, rather than just reproduction. For future studies, the authors planned for in vivo studies to investigate the timing and functions of the non-hypophysiotropic release of GnRH and cotransmitter. Furthermore, they aim to study the significance of non-hypophysiotropic neurons projecting to broad brain regions release GnRH and other cotransmitter(s).

[the_background] =>

Neuromodulation is the function to modulate neural activities in regions to which the releasing hormone neurons project. In vitro studies of the brain showed that non-hypophysiotropic GnRHs were neuromodulating various sensory processing pathways. However, the functions of non-hypophysiotropic GnRH neurons in the daily activities of organisms were unclear. To understand those functions, this review summarized the anatomical and physiological properties of non-hypophysiotropic GnRH neurons and discussed their roles in vertebrates, mainly teleosts. The summary establishes an in-depth understanding of non-hypophysiotropic GnRH neurons. The analysis enhances the literature on vertebrates’ anatomy and physiology.

[the_sdg_impact] =>

New findings and reports related to vertebrates’ anatomy and physiology are valuable, especially for medicine and veterinary. The knowledge would contribute to improving the well-being of most living beings. Therefore, the output of this review helps to achieve UNSDG 14: Life Below Water and UNSDG 15: Life on Land by emphasizing the sustainability of vertebrates.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0138-y [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/hypophysiotropic-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/hypophysiotropic_8709245_1628397352.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0138-y [original_article_reference_fields] => Array ( [publication_title] => Multiple functions of non-hypophysiotropic gonadotropin releasing hormone neurons in vertebrates [journal_title] => Zoological Letters [publisher] => BMC [year] => July 2019 [subject] => Zoology; Biological Sciences ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [125] => WP_Post Object ( [ID] => 29336 [post_author] => 154 [post_date] => 2021-08-08 12:33:02 [post_date_gmt] => 2021-08-08 04:33:02 [post_content] => [post_title] => Method Used by Dicyemid in Locating New Hosts Revealed by Gene Expression Profiles [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => method-used-by-dicyemid-in-locating-new-hosts-revealed-by-gene-expression-profiles [to_ping] => [pinged] => [post_modified] => 2022-01-10 15:03:13 [post_modified_gmt] => 2022-01-10 07:03:13 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29336 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => FURUYA, Hidetaka Furuya (古屋秀隆) [researchers_position] => Department of Biological Sciences, Graduate School of Science, Osaka University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/dicyemid-.png [researchers_profile] => n/a (https://researchmap.jp/hfuruya-dicyemid?lang=en) [researchers_second_profile] => https://orcid.org/0000-0002-7086-3122 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => dopamine beta hydroxylase; gene ontology; gamma-aminobutyric acid; G-protein-coupled receptors [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/dicyemid-5.png [video] => [the_novelty] =>

To date, several aspects of dicyemid mesozoans’ lifecycle remain uncertain. In this study, the gene expression profiles characterization conducted at different life stages reveals new information of various biological processes of the organism. More genes were expressed in free-living infusoriform larvae when compared across the four life-cycle stages, primarily due to its need to search for new hosts in the open ocean. Neurotransmitters and neuropeptides, as well as short cilia, served as sensory functions for detecting new hosts. With that said, the experimental techniques employed in this study would be beneficial to other research on simple organisms and understanding their biological mechanisms.

[the_background] =>

Despite having a bare 30-cell composition as an adult, the life-cycle of dicyemid mesozoans has yet to be fully understood. It is known that there are four stages in the entire lifecycle of dicyemids, namely nematogens, vermiform larvae, rhombogens, and infusoriform larvae. Since obtaining samples of infusoriform larvae from the ocean has been a great challenge, researchers were unable to grasp how the larvae search for new hosts. Besides that, the infusoriform larvae’s sensory mechanism is obscure since they do not have a nervous system. By characterizing the gene expression profiles of the four stages of Dicyema japonicum, the biological functions of the dicyemid stages and potential sensory functions for detecting new hosts were discussed in detail in this study. The study of gene expression profiles showed great potential in understanding the significance of different life-cycle stages of organisms.

[the_sdg_impact] =>

Dicyemida is a tiny parasite that lives in the renal appendages of cephalopods like squid, octopus, cuttlefish, and many more. Since these aquatic animals are crucial to maintain the balance of the marine ecosystem and serve as food sources, it is vital for the infection mechanism of the parasites they carry and the effects on the host to be clearly understood. Generally, research on parasites is challenging due to their simplified morphology and complex lifecycles. Therefore, the techniques adopted in this study could be useful in facilitating further exploration of parasitism in other organisms. Indirectly, it contributes to the realization of UN SDG 9: Industries, Innovation & Infrastructure by supporting technology development, research, and innovation.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0146-y [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/dicyemid-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/dicyemid_8708888_1628394459.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0146-y [original_article_reference_fields] => Array ( [publication_title] => Gene expression profiles of dicyemid life-cycle stages may explain how dispersing larvae locate new hosts [journal_title] => Zoological Letters [publisher] => BMC [year] => November 2019 [subject] => Zoology; Biological Sciences ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [126] => WP_Post Object ( [ID] => 29314 [post_author] => 154 [post_date] => 2021-08-07 11:21:48 [post_date_gmt] => 2021-08-07 03:21:48 [post_content] => [post_title] => Role of Self-marker Proteins in Sea Pineapple’s Immune System [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => role-of-self-marker-proteins-in-sea-pineapples-immune-system [to_ping] => [pinged] => [post_modified] => 2022-01-10 15:01:29 [post_modified_gmt] => 2022-01-10 07:01:29 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29314 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MATSUMOTO, Midori (松本緑) [researchers_position] => Bioscience and Informatics, Keio University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/Halocynthia-.png [researchers_profile] => https://www.researchgate.net/profile/Midori-Matsumoto [researchers_second_profile] => https://orcid.org/0000-0003-4838-6179 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => room temperature; membrane protein; coomassie; phenol oxidase; botryllus schlosseri; monoclonal antibody; ciona intestinalis; artificial seawater; phosphate-buffered saline; halocynthia roretzi; polyvinylidene difluoride; bovine serum albumin; allorecognition; hemocyte; isoelectric focusing; periodic acid–schiff; immune system; major histocompatibility complex; natural killer; Ascidian [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/Halocynthia-5.png [video] => [the_novelty] =>

This study proposed a potential novel type of self-marker protein involved in the self and non-self-cells distinguishing mechanism in Halocynthia roretzi (sea pineapple) hemocytes. By examining the contact reactions (CR) of sea pineapple hemocytes, the membrane proteins (HrSMLP1) have been identified as responsible for the hemocyte’s role in allorecognition. A monoclonal antibody (mAb11B16B10) was synthesized to induce CR in hemocytes. As a result, phenol oxidase (PO) was released, which served as an important indicator to identify the self-marker proteins. The findings provided comprehensive insights into the allorecognition mechanism of invertebrate H. roretzi.

[the_background] =>

Allorecognition is part of the immune response of an organism to distinguish its tissues from those of another individual. There are three commonly recognized allorecognition types in ascidians, self-incompatibility, fusion/non-fusion reactions, and contact reactions (CRs). Past studies have successfully classified hemocytes in sea pineapples (H. roretzi) to be able to differentiate into nine different cell types, among which were due to CR. Thus, this study hypothesized that self-marker molecules are present on the surface of hemocyte membranes, and that PO-inducing levels change in response to changes in the state of self-marker molecules. However, there is a lack of evidence in terms of genetic data to support such claims to date. Therefore, this study investigates the allorecognition mechanism of H. roretzi by exploring the hemocyte structure and trigger. The findings serve as good references to understand the evolution of the immune system and the roles of self-marker proteins in organisms.

[the_sdg_impact] =>

Comprehensive knowledge of organisms and their biological mechanisms is essential to maintain the balance and enhance the natural ecosystem. Understanding the immune system that aids the evolution and survival of vertebrates and invertebrates brings conservatory measures a step closer. The findings of this study, which revealed new information of biomarkers vital to self and non-self-cells distinguishing mechanisms in marine organisms, such as H. roretzi, would potentially contribute to the realization of UNSDG 14: Life Below Water.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0149-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/Halocynthia-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/Halocynthia_8690530_1628305308.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0149-8 [original_article_reference_fields] => Array ( [publication_title] => A self-marker-like protein governs hemocyte allorecognition in Halocynthia roretzi [journal_title] => Zoological Letters [publisher] => BMC [year] => December 2019 [subject] => Zoology; Bioscience and Informatics ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [127] => WP_Post Object ( [ID] => 29192 [post_author] => 154 [post_date] => 2021-08-03 13:34:53 [post_date_gmt] => 2021-08-03 05:34:53 [post_content] => [post_title] => Crucial Mediating Mechanism in Color Vision of Butterfly via Heterologous Action Spectroscopy [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => crucial-mediating-mechanism-in-color-vision-of-butterfly-via-heterologous-action-spectroscopy [to_ping] => [pinged] => [post_modified] => 2022-01-10 14:55:00 [post_modified_gmt] => 2022-01-10 06:55:00 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29192 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TERAKITA, Akihisa (寺北明久) [researchers_position] => Graduate School of Science, Osaka City University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/butterfly-4.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-8379-8913 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => visual pigment; absorption spectra; glutamic acid; convergent evolution; spectroscopy; chromophore; rhodopsin; light-emitting diode; color vision; ;amino acid residue; papilio xuthus; G protein-coupled receptors [graphic_abstract] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/butterfly-5.png [video] => [the_novelty] =>

For insects and other invertebrates, the spectral tuning mechanism of their color vision is largely unknown. To shed some light on this matter, this study adopted a methodology previously developed by the research group known as heterologous action spectroscopy. This technique revealed that two amino acids at positions 116 and 120 in helix III of butterfly Papilio xuthus long-wavelength-sensitive (LWS) opsins play a significant role in its spectral tuning mechanism. The helix III yielded a difference of about 15 nm in the wavelength of absorption maxima of PxRh1 and PxRh3 LWS opsins. With such detailed results, heterologous action spectroscopy has proven to be a promising method for examining invertebrates' visual systems, and its application could potentially be extended to understand other invertebrates.

[the_background] =>

Spectral tuning in visual systems of organisms is a crucial ability to sense a wider range of visible light wavelengths. This ability is closely related to opsins, a group of proteins made light-sensitive via the chromophore retinal found in photoreceptor cells of the retina. Past studies have indicated that distinct spectral tuning mechanisms are employed in the visual opsins of vertebrates and invertebrates. However, the tuning mechanism of invertebrates remains unclear due to the challenges in obtaining purified recombinant pigments. In fact, at present, there is no adsorption spectrum of the butterfly color-opsin available too. Therefore, this study adopts the heterologous action spectroscopy technique to obtain the absorption spectra of wild type PxRh1 and PxRh3 LWS opsins which share 81.7% amino acids. Besides confirming a spectral tuning mechanism different from primate LWS opsins, this method also reveals the potential spectral tuning mechanism in butterfly LWS opsins.

[the_sdg_impact] =>

Efficient research methodologies and equipment are the keys to the advancement of scientific research. This study proved the usefulness of heterologous action spectroscopy in understanding the visual system of invertebrates, which was initially challenging. Such development in research techniques does not just provide in-depth knowledge of previously unknown biological mechanisms of invertebrates, but also models an innovative future for scientific research methodologies. (UNSDG 9: Industry, innovation and infrastructure)

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0150-2 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/butterfly-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/08/butterfly_8574526_1627966387.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0150-2 [original_article_reference_fields] => Array ( [publication_title] => Spectral tuning mediated by helix III in butterfly long wavelength-sensitive visual opsins revealed by heterologous action spectroscopy [journal_title] => Zoological Letters [publisher] => BMC [year] => December 2019 [subject] => Zoology; Entomology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [128] => WP_Post Object ( [ID] => 28879 [post_author] => 154 [post_date] => 2021-07-14 21:09:58 [post_date_gmt] => 2021-07-14 13:09:58 [post_content] => [post_title] => Control Flying Insect Outbreaks by Manipulating Light Wavelengths and Understanding Weather Conditions [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => control-flying-insect-outbreaks-by-manipulating-light-wavelengths-and-understanding-weather-conditions [to_ping] => [pinged] => [post_modified] => 2022-01-10 10:39:38 [post_modified_gmt] => 2022-01-10 02:39:38 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28879 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NISHINO, Hiroshi (西野浩史) [researchers_position] => Research Institute for Electronic Science, Hokkaido University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/07/insects-.png [researchers_profile] => https://www.researchgate.net/profile/Hiroshi-Nishino [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => gypsy moth; oak silkmoth; chafer; fluorescent light; light-emitting diode (LED); light trap; meteorological factors; subarctic region [graphic_abstract] => [video] => [the_novelty] =>

The novelty of this study is attributed to its environmentally friendly method of controlling insect activity within public spaces in sub-arctic climate regions. An extensive field survey based in Hokkaido found that different wavelengths of light and weather conditions affected insect activity. In specific, aquatic insects and winged ants were drawn to broadband light wavelengths while moths and beetles were attracted to short light wavelengths. An examination of weather parameters among Gypsy moths and Japanese oak silkmoths revealed that Gypsy moths were positively correlated with the highest ambient temperature on the catch day. Especially, suitable range (22-24 ˚C) of dusk temperature promoted their synchronous mass flight. 380 nm LED, which is more cost-effective and energy-efficient than UV LEDs (<370 nm), was sufficient for capturing both moth species.

[the_background] =>

Insect outbreaks not only affect agriculture but can also be an aesthetically and practically unpleasant experience, especially within commercial spaces. Past studies neither tackled the influence of weather factors on insect activity nor were they applicable to commercial settings. Therefore, this study performed a 4-year long insect survey using light traps to observe different species of insects. The study then manipulated LED light wavelengths to observe light orientation among different species, besides weather variables. Findings from this study serve as an environmentally-friendly guide to manage insect outbreaks.

[the_sdg_impact] =>

The United States Department of Agriculture highlights the influence of climate change on forest insect outbreaks. Therefore, there is a need for sustainable measures that incorporate the climate to curb insect outbreaks without entirely relying on it. As proposed by the United Nations’ Sustainable Development Goal 15, specifically target 9, this study successfully integrates light technology and weather factors to curb insect outbreaks in local commercial spaces without known damage to the environment.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-00163-7 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/07/insects-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/07/insects_8082462_1626267207.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-020-00163-7 [original_article_reference_fields] => Array ( [publication_title] => Management of flying insects on expressways through an academic-industrial collaboration: evaluation of the effect of light wavelengths and meteorological factors on insect attraction [journal_title] => Zoological Letters [publisher] => BMC [year] => November 2020 [subject] => Zoology; Entomology; Electronic Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/07/insects-4.png ) ) [129] => WP_Post Object ( [ID] => 28743 [post_author] => 154 [post_date] => 2021-07-07 19:00:16 [post_date_gmt] => 2021-07-07 11:00:16 [post_content] => [post_title] => EMP-Proof Detector for Laser Nuclear Physics [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => emp-proof-detector-for-laser-nuclear-physics [to_ping] => [pinged] => [post_modified] => 2022-07-11 12:24:19 [post_modified_gmt] => 2022-07-11 04:24:19 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28743 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HU, Po [researchers_position] => School of Phys. Sci. and Tech, ShanghaiTech University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/07/EMP2.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => FU, Changbo [researchers_position_2] => Institute of Modern Physics, Fudan University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/07/EMP3.png [researchers_profile_2] => https://www.researchgate.net/profile/Chang-Fu-5 [researchers_second_profile_2] => https://orcid.org/0000-0001-5895-7823 ) [original_article_reference] => [research_footprints] => nuclear reaction; coulomb explosion; high energy; electromagnetic pulse; radiation detection; numerical aperture; nuclear physics; photomultiplier tubes [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/07/NST_Article-10_V0.jpg [video] => [the_novelty] =>

Would it be possible for a detector to accurately detect weak nuclear reactions signal in the HIL-induced plasma environments without being affected by the induced high electromagnetic pulse (EMP)? This study has developed a gated fiber detector (GFD) which was meant for that purpose. The main structure of the GFD included a reflective layer, a scintillating layer, a vacuum sealing glass window, a photon coupling cone, a fiber, and a gated photomultiplier tube (gPMT). Based on the results from numerical simulation, the optimal light-collecting efficiency was achieved in the development, which maximized the number of photons to be coupled by fiber and then transferred to a light detector (i.e., gPMT) located far away from the EMP source. Online tests confirmed that the detector was performing up to expectation and its response time was as short as 70 ns. Future optimization could be explored by collecting feedback from actual utilization.

[the_background] =>

The demand for studying nuclear reactions in laser-induced high-temperature plasma environments is increasing. Nevertheless, extremely high EMPs are commonly induced in such environments, thus crippling the functions of many traditional detectors. To overcome these complications caused by EMPs, this study has designed a detector that potentially avoids the effect of EMPs, yet still, be capable of identifying a single event of nuclear reaction products. By overcoming the EMPs, the detector was feasible to be utilized as time-of-flight (TOF) detector in high-intensity laser nuclear physics experiments. Such a development would help to achieve the goals of various studies related to laser nuclear physics.

[the_sdg_impact] =>

The potential of laser-induced nuclear physics has attracted a considerable amount of attention. With continuous progress and development, it is believed to be a window for new technologies in multidisciplinary. Apart from eliminating the hurdles caused by EMPs, this development also creates opportunities to widen the direction of studies related to laser nuclear physics. Hence, by enhancing the progress in peacefully using laser and nuclear techniques, this study materialized the UN SDG Goal 9: Industry, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00898-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/07/Laser-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/07/Laser_7821087_1625399847.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00898-8 [original_article_reference_fields] => Array ( [publication_title] => Development of gated fiber detectors for laser-induced strong electromagnetic pulse environments [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => June 2021 [subject] => Engineering; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/aR37FLFTy_E [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/07/10-2021.08.19.mp4_snapshot_00.01_2021.08.19_12.44.15.png [figures] => ) ) [130] => WP_Post Object ( [ID] => 28729 [post_author] => 154 [post_date] => 2021-07-07 18:54:08 [post_date_gmt] => 2021-07-07 10:54:08 [post_content] => [post_title] => New Technique for Precise Measurement of Nuclei’s Angular Distribution [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => new-technique-for-precise-measurement-of-nucleis-angular-distribution [to_ping] => [pinged] => [post_modified] => 2022-07-11 12:22:37 [post_modified_gmt] => 2022-07-11 04:22:37 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28729 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NAN, Wei [researchers_position] => China Institute of Atomic Energy, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/07/Nuclei4.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-1972-1364 ) [researchers_info_2] => Array ( [researchers_name_2] => GUO, Bing [researchers_position_2] => China Institute of Atomic Energy, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/07/Nuclei5.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-4911-0847 ) [original_article_reference] => [research_footprints] => exotic nuclei; halo nucleus; coulomb barrier; nuclear physics; heavy-ion; elastic scattering; time of flight [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/07/NST_Article-9_V1_EN-1-1-scaled.jpg [video] => [the_novelty] =>

Is it feasible to perform measurements at accelerators using the isotope separator on-line (ISOL) technique? This study confirmed the feasibility by performing the first-ever proof-of-principle experiment with a post-accelerated 23Na beam (using the ISOL technique). Such was primarily made possible by measuring the angular distribution of 23Na + 40Ca elastic scattering. The angular distribution measured showed consistency with the high-precision Q3D magnetic spectrograph measurements (using non-ISOL beam). Thus, this breakthrough enables researchers to explore the potential properties of non-stable Na isotopes by measuring the angular distribution of 21,22Na + 40Ca elastic scattering.

[the_background] =>

A nuclear drip line is a boundary delimiting the zone beyond which atomic nuclei decay by the emission of a proton or neutron. Nuclei with short life, unstable, radioactive are known to be exotic when they develop unusual structures. Meanwhile, the reaction dynamics of light exotic nuclei near the drip line have been getting significant attention, especially from the low-energy nuclear physics community. Several important properties of exotic nuclei include the size and surface diffusiveness which can be determined using elastic scattering. Such measurements were commonly performed at accelerators using the projectile fragmentation technique. However, reported studies that applied the ISOL technique for the same purpose were rare. By presenting the above-mentioned proof-of-principle experiment conducted at the Beijing Radioactive Ion Beam Facility (BRIF), the potential and feasibility of the technique were proven in this study. Furthermore, the output of this research gave validation for scientists to apply the ISOL technique in relevant investigations of the reaction dynamics of exotic nuclei.

[the_sdg_impact] =>

The properties of exotic nuclei can become very different from those of stable isotopes. That implies the existence of unexplored applications of exotic nuclei in nuclear technology. By introducing a highly reliable technique for the characterization of nuclei, this study established a strong foundation for future studies of exotic nuclei. Hence, it contributes to the realization of UNSDG 9: Industries, Innovation & Infrastructure by supporting future research related to nuclear science.

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00889-9 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/07/Nuclei.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/07/Nuclei_7819749_1625393611.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00889-9 [original_article_reference_fields] => Array ( [publication_title] => First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF: measurement of the angular distribution of 23Na + 40Ca elastic scattering [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => May 2021 [subject] => Engineering; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/UxTeri00KTo [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/07/09.mp4_snapshot_00.01_2021.08.03_10.58.16.png [figures] => ) ) [131] => WP_Post Object ( [ID] => 28702 [post_author] => 154 [post_date] => 2021-07-04 17:53:41 [post_date_gmt] => 2021-07-04 09:53:41 [post_content] => [post_title] => Charge Resolution in the Isochronous Mass Spectrometry [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => charge-resolution-in-the-isochronous-mass-spectrometry [to_ping] => [pinged] => [post_modified] => 2022-07-11 12:18:51 [post_modified_gmt] => 2022-07-11 04:18:51 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28702 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ZHOU, Xu [researchers_position] => Institute of Modern Physics, Chinese Academy of Sciences, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/07/isochronous-.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0001-8744-2909 ) [researchers_info_2] => Array ( [researchers_name_2] => WANG, Meng [researchers_position_2] => Institute of Modern Physics, Chinese Academy of Sciences, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/07/isochronous-2.png [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => isochronous mass spectrometry; charge resolution; signal amplitude; micro-channel plate [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/07/NST_Article-8_V2.jpg [video] => [the_novelty] =>

The mass measurements of short-lived nuclei require advanced facilities as well as high-level knowledge and skills. This study reports a new analysis method for isochronous mass spectrometry (IMS) experiments that led to significant improvements in charge resolution for ions. By considering the signal amplitudes, detection efficiencies, and the number of stored ions in the heavy-ion storage ring, ion pairs with nearly identical mass-to-charge (m/q) ratios can be resolved in terms of their revolution times. The new method enabled a complete resolution of 34Ar and 51Co in this study. Additionally, a consistent mass excess of 51Co was determined.

[the_background] =>

IMS of heavy-ion storage rings is a powerful technique to measure the mass of short-lived nuclei. Its working principle relies highly on its ability to measure the revolution times of ions precisely. Nonetheless, there was a limitation in the measurements for pairs of ion species with nearly identical m/q ratios. To address this, the researchers analyzed the amplitudes of the timing signals from the detector based on the emission of secondary electrons in a previous study. The introduction of a new analysis method was able to deduce revolution times with differences as low as 1.8 ps. This led to a higher charge resolution, enabling the complete resolution of 34Ar and 51Co (A/Z = 17/9). The new analysis method would facilitate the progress of other atomic and nuclear physics experiments using similar types of detectors.

[the_sdg_impact] =>

Nuclear technologies are useful to meet some of the fundamental needs of modern daily life. These include access to energy and proper medical care, food production, water resources management, and many more. Having effective methods to study exotic short-lived nuclei could open up endless possibilities for further exploring nuclear technology applications. The new analysis method reported by this study has enabled accurate characterizations of short-lived nuclei. Its contributions, aligned with UNSDG 9: Industries, Innovation & Infrastructure, promises the enhancement of scientific research necessary for upgrading existing and future nuclear technological capabilities.

[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00876-0 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/07/isochronous-5.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/07/isochronous_7819391_1625391792.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00876-0 [original_article_reference_fields] => Array ( [publication_title] => Charge resolution in the isochronous mass spectrometry and the mass of 51Co [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => April 2021 [subject] => Engineering; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/ySpChIc-Jhs [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/07/08.mp4_snapshot_00.01_2021.08.19_12.39.49.png [figures] => ) ) [132] => WP_Post Object ( [ID] => 28618 [post_author] => 154 [post_date] => 2021-06-27 20:06:42 [post_date_gmt] => 2021-06-27 12:06:42 [post_content] => [post_title] => A Novel Annotation-free Whole-slide Classification of Lung Cancer Pathologies Classification [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => a-novel-annotation-free-whole-slide-classification-of-lung-cancer-pathologies-classification [to_ping] => [pinged] => [post_modified] => 2021-06-27 20:06:42 [post_modified_gmt] => 2021-06-27 12:06:42 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28618 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHEN, Cheng-Yu [researchers_position] => Department of Radiology, College of Medicine, Taipei Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/06/annotation.png [researchers_profile] => https://www.researchgate.net/profile/Cheng-Yu-Chen-3 [researchers_second_profile] => https://orcid.org/0000-0003-0428-4373 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => pathology; hematoxylin and eosin; unified memory; deep learning; recurrent neural network; Deep neural networks; squamous cell carcinoma; convolutional neural networks; adenocarcinoma; lung cancer; support vector; machine; neural network; multiple-instance learning; artificial intelligence; radial basis function [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/06/annotation-5.png [video] => [the_novelty] =>

This study highlights the development of a whole slide training method to train convolutional neural network (CNN) for pathological classification of lung cancers. This method is superior to the existing digital diagnosis methods, such as the multiple-instance learning (MIL) method. A total of 7003 slides were gathered, consisting of 2039 cases of non-cancer, 3876 of adenocarcinoma, and 1088 cases of squamous carcinoma. The slides were randomly assigned for training, validation, and testing purposes. The slides were then subjected to different model performance testing to study various parameters in image analysis in lung cancer. In this study, whole slide imaging (WSI) used recorded superior results to MIL in terms of visualization, small lesion diagnosis, image resolution (despite the impact of data size), and memory consumption. Provided that there’s a limitation on host memory when training larger images on CNN, future research to identify a more memory-efficient algorithm will further optimize the model in the digital diagnosis of diseases.

[the_background] =>

CNN is a deep neural network in artificial intelligence (AI) designed for image analysis. It is a deep learning algorithm representing image input, extracts the importance of every bit of the image (each neuron), and distinguishes one image from another. In nonsmall-cell lung cancer (NSCLC), proper pathological diagnosis to differentiate between adenocarcinoma and squamous cell carcinoma presents a challenge, as the difference in pathological features between them is subtle. Hence, CNN has been the primary method used in image recognition in distinguishing these two histologically different NSCLC subtypes. Despite its success in tumor type identification and classification, the path-based CNN method demands substantial annotations on the slides by experienced pathologists. MIL, another technique employed to reduce the annotation burden, is subject to incorrect selection of patches for diagnosis or classification in early training, leading to compromise in the model’s performance. To overcome the limitations of existing methods, this study proposes using WSI to train CNN utilizing slide-level labels, the outcome of which intends to prove the superiority of this approach.

[the_sdg_impact] =>

Since the introduction of WSI in 1991, it has achieved remarkable growth in technology and is recognized in various applications in pathological diagnosis. The approval of the US FDA to a WSI system for primary surgical pathology diagnosis in 2017 has paved the way for the acceptance of this technology for broader medical applications. Given that the health demand is increasing by the day, non-laborious, highly efficient technology is snatching importance in enhancing diagnosis and disease classification processes. Thus, the utilization of WSI to train CNN in the diagnosis and classification of lung cancer becomes imminently crucial and contributes to the realization of United Nations Sustainable Development Goal (UNSDG) 3, good health and well-being.

[article_url] => https://www.nature.com/articles/s41467-021-21467-y [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/06/annotation-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/06/annotation_7633809_1624794870.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41467-021-21467-y [original_article_reference_fields] => Array ( [publication_title] => An annotation-free whole-slide training approach to pathological classification of lung cancer types using deep learning [journal_title] => Nature Communications [publisher] => Springer Nature [year] => February 2021 [subject] => Medical; Radiology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [133] => WP_Post Object ( [ID] => 28594 [post_author] => 154 [post_date] => 2021-06-27 20:01:24 [post_date_gmt] => 2021-06-27 12:01:24 [post_content] => [post_title] => COVID-19 Infection Risk in Cancer Patients [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => covid-19-infection-risk-in-cancer-patients [to_ping] => [pinged] => [post_modified] => 2021-06-27 20:01:24 [post_modified_gmt] => 2021-06-27 12:01:24 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28594 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LIN, Liang-Tzung [researchers_position] => Department of Microbiology and Immunology, College of Medicine, Taipei Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/06/Elevation-.png [researchers_profile] => https://www.researchgate.net/profile/Liang-Tzung-Lin [researchers_second_profile] => https://orcid.org/0000-0001-7374-7234 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => acute respiratory distress syndrome; The Cancer Genome Atlas; coronavirus disease; innate immunity; cathepsin L; angiotensin-converting enzyme 2; Gene Expression Omnibus; cancer patient; covid19 [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/06/Elevation-5.png [video] => [the_novelty] =>

This study investigated the intricate relationship between cancers, anti-cancer treatments, and SARS-CoV-2 infection to understand possible modifications needed for the clinical management of cancer patients. Large-scale genome-wide transcriptional analysis revealed that RNA expression of three significant genes responsible for SARS-CoV-2 entry into cells, including ACE2, TMPRSS2, and CTSL, were upregulated in different cancer tissues assessed. These viral entry genes were also upregulated in male patients and those who smoke and transiently increased during radiotherapy. In addition, chemotherapy and radiotherapy both transiently dysregulated the immune system in cancer patients. These alterations possibly predisposed this cohort to higher susceptibility and severity of COVID-19. Findings from this study urge further investigation of the complex relationship between cancers and COVID-19 to optimize treatment strategies for both diseases in cancer patients.

[the_background] =>

Similar to the closely related SARS-CoV, SARS-CoV-2, the novel coronavirus responsible for COVID-19 mainly relies on the angiotensin-converting enzyme 2 (ACE2) type I membrane protein, host cell serine protease transmembrane protease serine 2 (TMPRSS2), and endosomal cysteine protease cathepsin L (CTSL) to enter target cells. The expression of these proteins allows SARS-CoV-2 infection, which then triggers host antiviral response. However, SARS-CoV-2 can also deregulate the immune system, leading to a hyperinflammatory reaction with cytokine over-production that contributes to COVID-19 progression and severity. Based on the increased prevalence and severity of COVID-19 in cancer patients reported in multiple previous cohorts, this study aimed to examine the expression of SARS-CoV-2 entry genes in various cancer tissues and the effect of radiotherapy and chemotherapy on these viral entry genes and host immune responses.

[the_sdg_impact] =>

COVID-19 pandemic has caused over 150 million cases and approximately 3 million deaths worldwide as of mid-2021. Cancer patients are four times more likely to be infected by SARS-CoV-2 than the general population, making it a big concern to both patients and oncologists. Hence, identifying risk factors of COVID-19 in cancer patients is vital to reducing morbidity and mortality in this group. In line with that, the findings of this study are imperative to guide clinicians and oncologists on the management of cancers during the COVID-19 pandemic to alleviate potential complications that could impose a huge health burden on the global health system. Ideally, such an endeavor is crucial to uphold the UNSGD 3: Good health and well-being, aiming to improve global health and, thus, global public health. With the pandemic being the current health emergency globally, every effort at improving its management becomes an integral part of fighting the battle.

[article_url] => https://www.nature.com/articles/s41598-021-83366-y [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/06/Elevation-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/06/Elevation_7633745_1624794543.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1038/s41598-021-83366-y [original_article_reference_fields] => Array ( [publication_title] => Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients [journal_title] => Scientific Reports [publisher] => Springer Nature [year] => February 2021 [subject] => Medical; Microbiology; Immunology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [134] => WP_Post Object ( [ID] => 28523 [post_author] => 154 [post_date] => 2021-06-21 10:28:31 [post_date_gmt] => 2021-06-21 02:28:31 [post_content] => [post_title] => Monte Carlo Simulations Made Better with New CMGC Model [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => monte-carlo-simulations-made-better-with-new-cmgc-model [to_ping] => [pinged] => [post_modified] => 2022-06-15 11:00:36 [post_modified_gmt] => 2022-06-15 03:00:36 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28523 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WANG, Xin (王鑫) [researchers_position] => Institute of Applied Physics and Computational Mathematics, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/06/CMGC.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Xin-Wang-2115195460 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => LI, Junli (李君利) [researchers_position_2] => The Department of Engineering Physics (DEP), Tsinghua University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/06/CMGC2.png [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => footnote; computer-aided design; boundary representation; constructive solid geometry; graphical user interface; Monte Carlo; CAD; geometry converter; complete solid decomposition [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/06/NST_Article-02-1.jpg [video] => [the_novelty] =>

This study elaborates the algorithms, implementations, and applications of a new computer-aided design (CAD) model to Monte Carlo geometry converter (CMGC). This newly developed conversion code promises highly efficient Monte Carlo simulations by generating appropriate constructive solid geometry (CSG) representation. As a result, this automatic conversion can produce heuristic strategies for solid splitting, reduce the time taken for particle transporting, provide low relative volume error, and has a friendly graphical user interface. At the end of the CMGC conversion, the converted models show high accuracy and improved efficiency in particle transport calculations.

[the_background] =>

The computer-aided design (CAD) model to Monte Carlo geometry conversion is recognized as the most effective automatic conversion method compared to the conventional boundary representation model. Recent researches have been heavily focused on improving the efficiency of large-scale and detailed Monte Carlo modeling. Among the areas of focus are to reduce manual work, increase conversion speed, and improve conversion accuracy. This study aims to provide an in-depth analysis of a new conversion method and demonstrate its improved Monte Carlo simulation efficiency.

[the_sdg_impact] =>

The Monte Carlo methods are very common and preferred when designing sophisticated nuclear systems due to their capability of dealing with complex problems with high accuracy. Radiation technology and computational medicine physics, among other fields, are known to benefit from an efficient and safe interface such as the CMGC model mentioned in this study. Therefore, the detailed description in this study would serve as a good reference for future infrastructure upgrading with increased resource-use efficiency and accuracy, as proposed in the 9th UN Sustainable Development Goal: Industry, Innovation and Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-020-00793-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/06/CMGC3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/06/CMGC_7452112_1624241710.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-020-00793-8 [original_article_reference_fields] => Array ( [publication_title] => CMGC: a CAD to Monte Carlo geometry conversion code [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => August 2020 [subject] => Engineering; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/pzLLOl_TXzg [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/06/Monte-Carlo-simulations-made-better-with-new-CMGC-model.mp4_snapshot_00.01_2021.06.24_21.21.49.png [figures] => ) ) [135] => WP_Post Object ( [ID] => 28398 [post_author] => 154 [post_date] => 2021-06-11 10:35:04 [post_date_gmt] => 2021-06-11 02:35:04 [post_content] => [post_title] => Improved Version of Angle-resolved Photoemission Spectroscopy (ARPES) Makes In-situ Characterization of the Fine Electronic Structure of Condensed Matter Possible [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => improved-version-of-angle-resolved-photoemission-spectroscopy-arpes-makes-in-situ-characterization-of-the-fine-electronic-structure-of-condensed-matter-possible [to_ping] => [pinged] => [post_modified] => 2022-07-11 12:21:04 [post_modified_gmt] => 2022-07-11 04:21:04 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28398 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => Liu, Zhengtai [researchers_position] => State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/06/ARPES-.png [researchers_profile] => https://www.researchgate.net/profile/Liu-Zhengtai [researchers_second_profile] => https://orcid.org/0000-0002-3328-165X ) [researchers_info_2] => Array ( [researchers_name_2] => SHEN, Dawei [researchers_position_2] => State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/06/ARPES-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Dawei-Shen/publications [researchers_second_profile_2] => https://orcid.org/0000-0003-2402-7956 ) [original_article_reference] => [research_footprints] => reflection high-energy electron diffraction; angle-resolved photoemission spectroscopy; molecular beam epitaxy; scanning tunneling microscopy; light source; X-ray diffraction; photoemission spectroscopy; low-energy; electron diffraction; ultrahigh vacuum; high harmonic generation; synchrotron radiation; electronic structure; band theory; second harmonic generation; Shanghai Synchrotron Radiation Facility [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/06/NST_Article-07_V0-0601_001.png [video] => [the_novelty] =>

To meet the high requirements of sophisticated studies in condensed matter physics, this research has successfully designed and constructed a more advanced synchrotron angle-resolved photoemission spectroscopy (ARPES) beamline (BL03U) and an endstation at the Shanghai Synchrotron Radiation Facility (SSRF). The BL03U endstation consists of an ARPES system, a load-lock chamber, an oxide molecular beam epitaxy (OMBE) system, a scanning tunneling microscopy (STM) system, and a UFO-like transfer chamber. The beam spot produced by the ARPES system is as fine as 7.5 um (V) × 67 um (H) with the fundamental photon range of 7 to 165 eV. Photoemission with an energy resolution of 2.67 meV (at 21.2 eV photon energy) was achieved by the newly developed ARPES system. By equipping the ARPES system with a six-axis cryogenic sample manipulator (minimum temperature of 7 K), the BL03U endstation provides an essential platform to carry out in-situ characterization of the electronic structure of condensed matter. Such a development has demonstrated the versatility of an ARPES endstation to be enhanced to support future studies in condensed matter physics.

[the_background] =>

Conventional ARPES is well-known for its capability in characterizing the electronic properties of correlated materials and the electronic structure of correlated electron systems. Nonetheless, conventional ARPES faced several bottlenecks when it was applied in the recent development of quantum materials which has higher characterization requirements in terms of photon energy, flux, and beam spot. Besides that, quantum material samples with a flat surface along the desired crystalline orientation were difficult to be prepared for characterization under ARPES. To address these limitations, a more superior ARPES endstation has been developed by this study. Furthermore, with the OMBE system and connected growth chamber, epitaxial growth techniques are able to be applied to realize in-situ ARPES measurements without the need for tedious sample preparation. By having the state-of-the-art features, this facility will boost the advancement of studies in condensed matter physics.

[the_sdg_impact] =>

The improvement of ARPES will help condensed matter physicists to better understand the behavior of more exotic condensed phases include the superconducting phase exhibited by certain materials at low temperature. More experiments can be conducted using the improved facility to measure various material properties, and by applying the physical laws of quantum mechanics, electromagnetism, statistical mechanics, and other theories to develop mathematical models. Such innovative facility is a great contribution to the research infrastructure that supporting and aligning to the UNSDG 9: Industries, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00858-2 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/06/ARPES-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/06/ARPES_7223959_1623378164.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00858-2 [original_article_reference_fields] => Array ( [publication_title] => High-resolution ARPES endstation for in situ electronic structure investigations at SSRF [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => March 2021 [subject] => Engineering; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/cQ_tyEaiPHg [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/06/ARPES-6.jpg [figures] => ) ) [136] => WP_Post Object ( [ID] => 28266 [post_author] => 154 [post_date] => 2021-05-27 20:18:15 [post_date_gmt] => 2021-05-27 12:18:15 [post_content] => [post_title] => How do the Elderly Community Obtain Health Information? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => how-do-the-elderly-community-obtain-health-information [to_ping] => [pinged] => [post_modified] => 2021-09-07 10:19:43 [post_modified_gmt] => 2021-09-07 02:19:43 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28266 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => AHMAD, Normawati [researchers_position] => Institute for Health Behavioural Research, National Institutes of Health, Ministry of Health, Malaysia. [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/normawati.png [researchers_profile] => [researchers_second_profile] => https://orcid.org/0000-0002-9398-0495 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => elderly; daily life; internet access; health information [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/g46d.png [video] => [the_novelty] =>

This study provides evidence of the increase in digital dependency, usage, and literacy among the elderly community when seeking health information. The most common information searched online is on diseases and disease-related nutrition advice. Consistent with previous findings, elderly people prefer using the internet to search for health information because of accessibility and convenience. However, the amount of information presented can be overwhelming with risks of misinformation if they are uncertain of how to identify the right source. Therefore, health information providers should consider the internet as a source of knowledge dissemination and support the elderly population by directing them to official channels to seek information. Such behavioral understanding could potentially be expanded into monitoring and surveillance of the aged community.

[the_background] =>

The ‘Dr. Google’ phenomenon is widely observed with the growing internet accessibility. Apart from encouraging social interaction and collaboration, the internet has become a reliable channel for many to continuously learning about their health and seek advice to improve their conditions. As the elderly community is among those most prone to a range of diseases and illnesses, seeking quick and comprehensive information on their health becomes the priority when using the internet. Having said that, little is known of the Malaysian elderly behavior when it comes to internet dependency and online health information-seeking habits. Therefore, this study chose to profile residents of 23 Elderly Activity Centres across Malaysia to understand the online health information-seeking pattern of the elderly.

[the_sdg_impact] =>

Graceful and healthy aging could be supported with the right tools and systems in place. With health-related information being shared openly and rapidly on many online platforms, knowledge accessibility has certainly improved over the years. In order to protect and support the elderly population in having access to such valuable information and promote lifelong learning, health staff should encourage digital health literacy for older adults as foundations for learning and decision-making (SDG 4: Quality education). With that, the elderly community would not be left out in terms of accessing information on disease prevention, treatment, and rehabilitation to maintain their health and independence (SDG 3: Good health and well-being). However, to work on the mentioned areas, health information providers and policymakers should first understand the digital usage patterns and behaviors of the elderly community. The data offered by this study would be useful to design a more efficient and effective health information dissemination medium.

[article_url] => https://doi.org/10.36713/epra4422 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/elderly-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Elderly_9490701_1630981148.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.36713/epra4422 [original_article_reference_fields] => Array ( [publication_title] => USAGE OF INTERNET FOR HEALTH INFORMATION SEEKING AMONG ELDERLY IN MALAYSIA [journal_title] => EPRA International Journal of Multidisciplinary Research (IJMR) [publisher] => EPRA International Journal of Multidisciplinary Research (IJMR) [year] => May 2020 [subject] => Social Science; Humanities ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [137] => WP_Post Object ( [ID] => 28249 [post_author] => 154 [post_date] => 2021-05-27 20:03:07 [post_date_gmt] => 2021-05-27 12:03:07 [post_content] => [post_title] => Understanding Diabetic Patients’ Perception towards Conventional and Herbal Medicine [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => understanding-diabetic-patients-perception-towards-conventional-and-herbal-medicine [to_ping] => [pinged] => [post_modified] => 2021-09-07 10:16:11 [post_modified_gmt] => 2021-09-07 02:16:11 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28249 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ITHNAIN, Norbaidurah [researchers_position] => Institute for Health Behavioral Research, National Institute of Health Ministry of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/diabetic-.png [researchers_profile] => https://www.researchgate.net/profile/Norbaidurah-Ithnain [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => conventional medicine; diabetes mellitus; qualitative study; patients; diabetes; herbal medicine; adverse effect; vascular disease; drug interaction [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Graphical-Norbaidurah.png [video] => [the_novelty] =>

The findings of this study contribute to a regional understanding of how diabetic patients manage their medications and why they choose to opt for herbal medicine instead of relying on clinic prescription. Focused mainly on patients undergoing treatment for Type 2 Diabetic Mellitus (T2DM), it was found that these patients are more inclined to incorporate herbal medicine to complement their conventional treatment regimen. Some have even chosen to alter the dosage and consumption timing of conventional medication to cater to their herbal medicine consumption timing, while some even consider quitting their clinical prescription and relying entirely on herbal treatment. These decisions result from a lack of confidence towards the effectiveness of synthetic drugs, their side effects, and the influence of family and friends. By understanding the patient perception towards conventional and herbal medicine, healthcare providers and policymakers could improve diabetes management to ensure medication safety.

[the_background] =>

Living in a multi-cultured society and growing preference towards natural products, it is becoming challenging for healthcare personnel to restrict their patients from seeking alternative treatment. The long-term reliance on existing synthetic drugs, slow observable results, and negative side effects have led more T2DM patients to choose herbal medicines over conventional medicine. At present, there are limited qualitative research data available that elaborates the reasons for what triggers such choices among patients. Therefore, this study intends to generate a detailed understanding of the perception, beliefs, and values of the T2DM patients in deciding their preferred treatment. With this knowledge, pharmacists and doctors could cater their medical advice to meet the needs and beliefs of their patients accordingly.

[the_sdg_impact] =>

The rate at which people are being diagnosed with T2DM is alarming; even more concerning is the attitude of these patients towards managing their conditions post-diagnosis. Diabetes control is part of the UNSDG 3, Good health and well-being, target, to reduce premature mortality and disabilities due to non-communicable diseases by 2030. To combat this global epidemic, multisectoral population-based research is crucial to prevent and manage this disease. This study allows healthcare providers and policymakers to understand patients’ sentiment towards the treatment regimen to improve the monitoring and educating process.

[article_url] => http://www.ccsenet.org/journal/index.php/gjhs/article/view/0/43530 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/diabetic.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Herbal_9490655_1630980922.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.5539/gjhs.v12n10p122 [original_article_reference_fields] => Array ( [publication_title] => Perception of Conventional Medicine and Herbal Medicine Usage Amongst Diabetic Patients: A Qualitative Study in Negeri Sembilan, Malaysia [journal_title] => Global Journal of Health Science [publisher] => Canadian Center of Science and Education [year] => August 2020 [subject] => Medical; Diabetes ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [138] => WP_Post Object ( [ID] => 28235 [post_author] => 154 [post_date] => 2021-05-27 19:41:15 [post_date_gmt] => 2021-05-27 11:41:15 [post_content] => [post_title] => How are Patients Responding to Health Education Services Provided in Clinics? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => how-are-patients-responding-to-health-education-services-provided-in-clinics [to_ping] => [pinged] => [post_modified] => 2021-09-13 10:18:20 [post_modified_gmt] => 2021-09-13 02:18:20 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28235 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => JAAFAR, Norrafizah [researchers_position] => Institute for Health Behavioural Research, Ministry of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/jaafar.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => healthcare system; health education; non-communicable diseases; ;thematic analysis; health care; liaison officers [graphic_abstract] => [video] => [the_novelty] =>

This study delineates patients’ experience in receiving health education services given by healthcare providers (HCPs) in clinics that have adopted the Enhanced Primary Health Care (EnPHC) initiative. As a whole, patients recognize the intention of including such intervention components and are willing to engage with HCPs in educating themselves to cope with their illnesses. However, they wish to have certain concerns and challenges to be addressed before fully reaping the benefits of the service provided. Among the factors identified to have caused patient scepticism towards receiving health education at secondary triage are the prolonged waiting period, lack of privacy at waiting area, repetitive message delivery, interpersonal relationship between patient and the health educators and the confidence in their credibility. Therefore, to ensure the effectiveness of the EnPHC initiative in educating the patients and supporting them in coping with their medical conditions, these feedbacks should be considered and acted upon by clinic management and health educators.

[the_background] =>

The introduction of the Enhanced Primary Health Care (EnPHC) initiative by the Malaysian government is to assist patients in coping with the complexity of living with non-communicable diseases (NCDs). With patient-centric service delivery as the primary motive, providing comprehensive health education and increasing patient awareness are identified as key components for the successful implementation of the EnPHC initiative. Although the intentions of including these components are clearly to benefit the patients, there is little knowledge of how the patients are perceiving such changes. Therefore, this study aims to understand patient perception and experience as recipients of health education at secondary triage. These feedbacks could then be used by the clinic management, health educators, and policymakers to improve the service delivery mechanism.

[the_sdg_impact] =>

According to the World Health Organization (WHO), preventing premature deaths and disabilities from non-communicable diseases (NCDs) is possible, cost-effective, and necessary for human and economic development (SDG 3: Good health and well-being). As the Malaysian healthcare system is currently undergoing transformation to improve the country’s essential healthcare service delivery, equipping the patients with sufficient knowledge about their illnesses and coping mechanism is considered as one of the most cost-effective interventions. The feedback gathered from this study would, thus, be useful for healthcare service providers to improvise the intervention delivery approaches.

[article_url] => https://journals.sagepub.com/doi/full/10.1177/2150132720980629 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/working.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Clinics_9490629_1630980771.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1177/2150132720980629 [original_article_reference_fields] => Array ( [publication_title] => Patients’ Perception Towards Health Education Services Received at the Enhanced Primary Healthcare Facilities: A Qualitative Exploration [journal_title] => Journal of Primary Care & Community Health [publisher] => Sage Publishing [year] => December 2020 [subject] => Medical; Social Science; Humanities ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/health5.png ) ) [139] => WP_Post Object ( [ID] => 28218 [post_author] => 154 [post_date] => 2021-05-27 19:26:08 [post_date_gmt] => 2021-05-27 11:26:08 [post_content] => [post_title] => Patient’s Experience in Receiving Medical Care with EnPHC [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => patients-experience-in-receiving-medical-care-with-enphc [to_ping] => [pinged] => [post_modified] => 2021-09-07 10:10:31 [post_modified_gmt] => 2021-09-07 02:10:31 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28218 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => JOHARI, Mohammad Zabri [researchers_position] => Institute for Health Behavioural Research, Ministry of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/EnPHC.png [researchers_profile] => https://www.researchgate.net/profile/Mohammad-Johari-3 [researchers_second_profile] => https://orcid.org/0000-0002-8017-622X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => patient; chronic disease; disease management; Intervention; service quality; primary health care; non-communicable disease [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/EnPHC2.png [video] => [the_novelty] =>

This study is part of a larger process evaluation study which intended to assess and report the effectiveness of the Enhanced Primary Health Care (EnPHC) initiative implementation in selected clinics through patient’s perception and experience. There were five main themes to which the assessment paid close attention to, namely health assessment in disease progress monitoring, patient-doctor relationship and continuity of care, professionalism in service delivery, ensuring compliance in achieving health targets, and communication skills. Based on the feedback received, although the patients were unaware of the EnPHC initiative implementation, positive responses towards the new changes were gathered. Overall, the government’s attempt to transform the existing clinic health care service delivery into more structured and detailed management by emphasizing patient-centered care is perceived as a success. However, future implementations and upgrades should focus on, first, increasing the level of awareness and improving the understanding of the intervention among patients to support their experience and increase acceptance.

[the_background] =>

In July 2017, the Ministry of Health Malaysia proposed implementing the Enhanced Primary Health Care (EnPHC) initiative to improve primary care intervention to cope with the rise in non-communicable diseases across the nation. The main focus of the initiative is to transform the existing clinic management into a more patient-centric system. Several changes have been put in motion to achieve the transformation, including redesigning work process in the clinic, improving community intervention through community enrolment and profiling, and smoothening the referral system between clinic and hospital. However, to ensure a favorable outcome, it is important to understand how these changes have benefited the patient experience. Therefore, this study aims to assess the effectiveness of the EnPHC implementation from the patient’s perception and experience.

[the_sdg_impact] =>

One of the targets of the 3rd United Nations’ Sustainable Development Goal, Good health and well-being, is to provide access to good-quality healthcare services as part of the attempt to ensure healthy lives and promote well-being for all. Accordingly, governments worldwide have pledged their commitments to meet the health needs of their people and improve the nation’s primary health care service delivery. The Enhanced Primary Health Care (EnPHC) initiative is Malaysia’s attempt to fulfil its pledge in putting the health needs of its people first. The findings of this study provide valuable information on patient experience and expectations, which could be used to ensure the continuous betterment of the nation’s healthcare system.

[article_url] => https://bmcfampract.biomedcentral.com/articles/10.1186/s12875-020-01254-2 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/EnPHC-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/EnPHC_9490599_1630980596.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s12875-020-01254-2 [original_article_reference_fields] => Array ( [publication_title] => Can patients make heads or tails of enhanced primary health care (EnPHC)? Experience through their own journey [journal_title] => BMC Family Practice [publisher] => BMC [year] => September 2020 [subject] => Social Science; Humanities; Health Care ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [140] => WP_Post Object ( [ID] => 28201 [post_author] => 154 [post_date] => 2021-05-27 17:26:51 [post_date_gmt] => 2021-05-27 09:26:51 [post_content] => [post_title] => What Mental Distress is Experienced by Interning Doctors and How to Deal with it? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => what-mental-distress-is-experienced-by-interning-doctors-and-how-to-deal-with-it [to_ping] => [pinged] => [post_modified] => 2024-01-13 15:05:29 [post_modified_gmt] => 2024-01-13 07:05:29 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28201 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ISMAIL, Munirah [researchers_position] => Institute for Health Management, National Institutes of Health (NIH), Ministry of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/munirah.png [researchers_profile] => https://www.researchgate.net/profile/Munirah-Ismail-3 [researchers_second_profile] => https://orcid.org/0000-0002-5864-5384 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => anxiety; psychological distress; medical intern; stress; COPE; healthcare professionals; mental health; health problem; medical internship; depression; cross sectional study [graphic_abstract] => [video] => [the_novelty] =>

This research performed the first national-level cross-sectional study to determine the prevalence of psychological distress and its association with coping strategies among medical interns in Malaysia. The three major psychological distresses examined were stress, anxiety, and depression. Based on the data collected, the majority of interns experienced anxiety (39.9%) throughout their internship period, followed by stress (29.7%) and depression (26.2%). Noticeably, female and younger interns are highly susceptible to these conditions. Nevertheless, there has been an overall decline in anxiety and stress experiences compared to a previous study, which indicates the effectiveness of improvement strategies implemented during internship training in recent years. Moreover, most of these interns were found to have adopted healthy problem-focused coping strategies to get through the intense training process and psychological distress. As a whole, the data presented in this study would benefit healthcare institutions in incorporating the reinforcement of healthy coping strategies to ensure the effectiveness of medical internship programs.

[the_background] =>

The intensity in performing life-saving acts day-in and day-out is overwhelming for medical practitioners, especially the newbies and interns. Every now and then, Malaysian interns and HOs make headlines due to stress, depression, being bullied, etc. Most of the time, the mental strength of these interns are being challenged as they juggle between doing it right and adapting to the new pace and demands. Consequently, these medical interns experience psychological distress at one point or another and would need to learn to cope with it in a healthy manner. In Malaysia, most studies focused on a single psychological distress condition or based in a single center. Since there is a lack of national-level data on the prevalence of psychological distress, this study aims to collect the necessary data on this matter and examine the coping mechanisms used by the medical interns.

[the_sdg_impact] =>

Mental health issues have been identified as major public health problems affecting the health of the people not excluding the health professional themselves. Higher levels of psychological distress were seen among healthcare professionals where their poor mental health can compromise the quality of life and work performance and quality of care to patients. By addressing the psychological challenges faced by them and the importance of equipping the doctors, especially the young ones, with the right coping skills mechanism when dealing with stressful environments so that their mental well being is taken care of. This also contributes to the 3rd SDG - Good Health Well Being.

[article_url] => https://bit.ly/3NMMMoY [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/psychological-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Distress_9490747_1630981333.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://bit.ly/3NMMMoY [original_article_reference_fields] => Array ( [publication_title] => The prevalence of psychological distress and its association with coping strategies among medical interns in Malaysia: A national-level cross-sectional study [journal_title] => Asia-pacific Psychiatry [publisher] => Wiley Publishing [year] => August 2020 [subject] => Social Science; Humanities ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/_wOd-50BxyE?si=T7L1OHFEto35Eytv [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Screenshot-2024-01-02-103646.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/psychological-2.png ) ) [141] => WP_Post Object ( [ID] => 28187 [post_author] => 154 [post_date] => 2021-05-27 17:14:57 [post_date_gmt] => 2021-05-27 09:14:57 [post_content] => [post_title] => Government Doctor’s Dilemma: To Stay or To Leave? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => government-doctors-dilemma-to-stay-or-to-leave [to_ping] => [pinged] => [post_modified] => 2021-09-13 10:20:25 [post_modified_gmt] => 2021-09-13 02:20:25 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28187 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ABDUL RASSIP, Muhammad Nur Amir [researchers_position] => National Institutes of Health, Ministry of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/amir.png [researchers_profile] => https://www.researchgate.net/profile/Muhammad-Nur-Amir-Bin-Abdul-Rassip [researchers_second_profile] => http://orcid.org/0000-0002-8162-1380 ) [researchers_info_2] => Array ( [researchers_name_2] => WAN PUTEH, Sharifa Ezat [researchers_position_2] => Department of Community Health, Faculty of Medicine, UKM Medical Centre, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/sharifa.png [researchers_profile_2] => https://www.researchgate.net/profile/Sharifa-Ezat-Ezat [researchers_second_profile_2] => https://orcid.org/0000-0001-6251-2528 ) [original_article_reference] => [research_footprints] => resignation; health system; degree of freedom; human resource management; healthcare professional; statistical package for the social sciences; job satisfaction [graphic_abstract] => [video] => [the_novelty] =>

The primary aim of this study is to identify the factors influencing physicians’ intention to continue serving in government hospitals instead of seeking positions in the private sector. Based on the survey conducted, job satisfaction towards governance and work processes are among the leading triggers to cause resignation. One of the effective policies established by the Ministry of Health in Malaysia is the Full Paying Patient (FPP) services which did not just improve physician retention rate, but also the quality of patient care. In a way, this initiation also reduced the government’s financial burden by allocating medical subsidies only to those who can’t afford them. The evidence gathered through this study is, therefore, capable of providing policymakers with simple guidelines in implementing appropriate and flexible strategies to retain and meet the needs of the workforce.

[the_background] =>

Many public sector physicians consider themselves overworked and under-compensated for all the hard work that is required from them. Thus, taking up an offer at a private hospital becomes more tempting. In fact, scholars of full government scholarships would prefer to practice under private hospitals and opt-out of the bondage due to these reasons as well as the fancy work environment. In order to keep up with the growing demands in the healthcare sector, decision-makers are required to introduce effective measures to retain their rapidly depleting workforce. Therefore, studies on physicians’ motivation to stay need to be understood and incorporated into the initiatives for a better outcome.

[the_sdg_impact] =>

The growing medical “brain drain” and healthcare worker shortages are concerning, especially for public sectors, rural areas, and low-income countries. Public health standards and priorities are compromised due to the migration of health professionals to urban areas, private sectors, and high-income nations. Hence, human resource management decision makers must consider the factors causing such phenomena when drafting policies. The findings of this study provide evidence-based data to guide these policymakers to improve healthcare workforce job satisfaction, wages, resources, and working conditions, ultimately increasing the retention rate in the least developed countries as intended by UNSDG 3: Good health and well-being.

[article_url] => https://www.alliedacademies.org/articles/physicians-intention-to-leave-from-malaysia-government-hospitals-with-existing-retention-strategy-13327.html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/doctors-6.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Government_9490785_1630981487.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.35841/public-health-policy.4.3.30-37 [original_article_reference_fields] => Array ( [publication_title] => Physicians intention to leave from Malaysia government hospitals with existing retention strategy. [journal_title] => Journal of Public Health Policy and Planning [publisher] => Allied Academies [year] => July 2020 [subject] => Social Science; Humanities ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/doctors-4.png ) ) [142] => WP_Post Object ( [ID] => 28170 [post_author] => 154 [post_date] => 2021-05-27 17:02:33 [post_date_gmt] => 2021-05-27 09:02:33 [post_content] => [post_title] => How do Malaysian Patients Benefit from the Cluster Hospital Initiative? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => how-do-malaysian-patients-benefit-from-the-cluster-hospital-initiative [to_ping] => [pinged] => [post_modified] => 2024-01-13 15:05:51 [post_modified_gmt] => 2024-01-13 07:05:51 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28170 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NG, Rui Jie [researchers_position] => Institute for Health Management, National Institutes of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Hospital-.png [researchers_profile] => https://www.researchgate.net/profile/Rui-Jie-Ng [researchers_second_profile] => https://orcid.org/0000-0001-5960-3939 ) [researchers_info_2] => Array ( [researchers_name_2] => KHAIRUL ANUAR, Ili Liyana [researchers_position_2] => Centre for Organisational Excellence Development, Institute for Health Management, Ministry of Health, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/ili.png [researchers_profile_2] => https://www.researchgate.net/profile/Ili-Khairul-Anuar [researchers_second_profile_2] => https://orcid.org/0000-0002-1871-5384 ) [original_article_reference] => [research_footprints] => healthcare system; patient satisfaction; systematic review; service delivery; integrated care; thematic analysis; healthcare service; universal health coverage; patient-centred care [graphic_abstract] => [video] => [the_novelty] =>

Based on the experience of Malaysian patients, this study highlights patient benefits from hospitals merging in the Cluster Hospital Initiative (CHI). The key benefits recognized are the changes in healthcare service, time spent on healthcare-related activities, and financial cost. After conducting interviews with Malaysian patients in these merged hospitals, researchers found that patients were satisfied with the increased availability of specialists and improved quality of care. Patients also complimented the shorter waiting time for medical procedures and consultation as well as reduced traveling time to the hospitals. Moreover, patients are pleased with the lower healthcare cost and higher financial savings as a result of this initiative. Nevertheless, this study can further expand by researching other features of this initiative, such as the healthcare personnel’s experience and assessing its efficiency.

[the_background] =>

Cluster Hospital Initiative (CHI), different from the conventional hospital mergers, focuses on integrating resources from a network of hospitals in the same region through a well-coordinated merger. Such practice has been widely adopted in many countries, more commonly in private healthcare systems. Malaysia only implemented the concept in 2010, inspired by evidence from other studies. Previous studies mainly focused on its impact on hospital efficiency, price and cost changes, clinical outcomes, and quality of care. However, this is one of the first studies to focus on the patients’ and caregivers’ experience after the establishment of CHI. This study intended to determine the patients’ and caregivers’ experience in the healthcare services of the CHI locations. This was done by conducting an in-depth interview with the patients and caregivers in these hospitals. This study could help create a comprehensive hospital merging system that allows all Malaysians access to quality hospital care.

[the_sdg_impact] =>

In an effort to support the Good Health and Well-being goal under the global Sustainable Development Goals, the Ministry of Health Malaysia aims to provide a more streamlined and cohesive healthcare delivery by utilising all facilities and shared resources. The merging of hospital services is a change in the existing way of healthcare being delivered to the people of Malaysia, therefore their acceptance and experience may provide useful insights to how the initiative can be improved for its longevity. With that in mind, this research looks into public acceptance and experience following the implementation of CHI. Ultimately, the findings could provide insights for policymakers to further strengthen the initiative towards its sustainability.

[article_url] => https://bit.ly/47zLhBT [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Hospital-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Cluster_9490822_1630981637.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://bit.ly/47zLhBT [original_article_reference_fields] => Array ( [publication_title] => Exploring Patients’ Experience on Hospital Merger: Have they benefited from Cluster Hospital Initiative in Malaysia? [journal_title] => Pertanika Journal of Social Science and Humanities [publisher] => UPM Press [year] => December 2020 [subject] => Social Science; Humanities ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/ZPa_LUnbwfU?si=0t8V84T81dBf2FTU [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Screenshot-2024-01-02-103847.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/Hospital-2.png ) ) [143] => WP_Post Object ( [ID] => 28156 [post_author] => 154 [post_date] => 2021-05-27 15:33:51 [post_date_gmt] => 2021-05-27 07:33:51 [post_content] => [post_title] => Mathematical Model to Forecast COVID-19 Transmission Amidst Movement Control Order [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => mathematical-model-to-forecast-covid-19-transmission-amidst-movement-control-order [to_ping] => [pinged] => [post_modified] => 2024-01-13 15:07:02 [post_modified_gmt] => 2024-01-13 07:07:02 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28156 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GILL, Balvinder Singh [researchers_position] => Institute of Medical Research, National Institutes of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/bal3.png [researchers_profile] => https://www.researchgate.net/profile/Balvinder-Gill [researchers_second_profile] => https://orcid.org/0000-0002-0738-2991 ) [researchers_info_2] => Array ( [researchers_name_2] => LABADIN, Jane [researchers_position_2] => Department of Computational Science and Mathematics, University Malaysia Sarawak, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/labadin.png [researchers_profile_2] => https://www.researchgate.net/profile/J-Labadin [researchers_second_profile_2] => https://orcid.org/0000-0003-0508-4277 ) [original_article_reference] => [research_footprints] => susceptible; movement control order; reproduction number; public health; middle east respiratory syndrome; isolation; exposed; severe acute respiratory syndrome; protective equipment; movement; movement control; non-pharmaceutical interventions; mathematical modelling; novel coronavirus; infectious; novel pathogen; epidemic control; crisis preparedness and response centre; COVID-19 [graphic_abstract] => [video] => [the_novelty] =>

This study estimated the COVID-19 transmission dynamics and provided forecasts of case trends by extending the previously developed SEIR mathematical model to include traced, exposed, infected, isolated, and quarantined components to develop a robust forecasting model, the study took into consideration parameters such as the proportion of close contacts traced per day, transmissibility, and probability of a susceptible person becoming infected. The findings of this study showed a reduction of peak active cases by 99.1% and average contact per case following the implementation of movement control order (MCO). Therefore, it is proven that the institution of effective control measures did contribute to lowering the spread of the virus. Overall, the results emphasize how crucial it is for the public to comply with the control measures. Policymakers and health authorities can use these findings as evidence to guide the timely institution of control measures in breaking the COVID-19 chain of transmission.

[the_background] =>

Little introduction is required to emphasize the devasting impacts of the COVID-19 pandemic. Despite intensive public health efforts in screening and imposing social-distancing and citywide lockdowns, the chain of transmission seems unbreakable, judging by the rise of global cases and deaths. Several studies have explored various mathematical models to understand the transmission dynamics and forecast the progress of the pandemic. The outcome of which has proven that efficient human-to-human transmission exists. However, there is a lack of evidence on the effect of movement control measures, isolation, and quarantine efforts on the transmission dynamics of COVID-19. Therefore, this study aims to develop a robust mathematical model forecasting COVID-19 transmission by considering the control measures implemented in the country.

[the_sdg_impact] =>

As of 1st August 2021, more than 140 million people have been infected by the COVID-19 virus, with almost 3.2 million lives lost. There are devasting reports of second-waves and third-waves affecting countries globally resulting in dire consequences in terms of health effects and deaths which are more severe than the previous waves. Although vaccination is being administered, strict control measures are still required to ensure the transmission is kept under control. The findings of this study are proof of the effectiveness of strict movement control orders in controlling the spreading of the virus in hopes of ending this pandemic (SDG 3: Good health and well-being).

[article_url] => https://bit.ly/48g4Z6M [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/COVID-19-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Mathematical_9524128_1631086667.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://bit.ly/48g4Z6M [original_article_reference_fields] => Array ( [publication_title] => Modelling the Effectiveness of Epidemic Control Measures in Preventing the Transmission of COVID-19 in Malaysia [journal_title] => International Journal of Environmental Research and Public Health [publisher] => MDPI [year] => July 2020 [subject] => Medical; Covid-19; Biomedical Epidemiology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/i3nhny6gV74?si=S7jFAMemteic97xs [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Screenshot-2024-01-02-104955.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/covid19GA.png ) ) [144] => WP_Post Object ( [ID] => 28142 [post_author] => 154 [post_date] => 2021-05-27 15:02:55 [post_date_gmt] => 2021-05-27 07:02:55 [post_content] => [post_title] => Genetic Profiling of the Malaysian Indian Community [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => genetic-profiling-of-the-malaysian-indian-community [to_ping] => [pinged] => [post_modified] => 2021-09-08 15:34:41 [post_modified_gmt] => 2021-09-08 07:34:41 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28142 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => AHMAD FAUZI, Nurul Aain [researchers_position] => Immunogenetic Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/community2.png [researchers_profile] => https://www.researchgate.net/profile/Nurul-Aain-Ahmad-Fauzi [researchers_second_profile] => https://orcid.org/0000-0001-5051-3961 ) [researchers_info_2] => Array ( [researchers_name_2] => TOO, Chun Lai [researchers_position_2] => Immunogenetic Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/community.png [researchers_profile_2] => https://www.researchgate.net/profile/Chun-Lai-Too-2 [researchers_second_profile_2] => https://orcid.org/0000-0002-4079-8454 ) [original_article_reference] => [research_footprints] => polymerase chain reaction; applied biosystems; indian diaspora; Haplotypes; allele frequency; medical research; alleles [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/210628_Phylogenetic-Tree-Pic_Final-Version.png [video] => [the_novelty] =>

This study reports the genetics information for the third largest ethnicity in Malaysia, the Southeast Asia Indian community. The genetic information for five different genes (i.e., HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1) were identified in 271 healthy Indian controls sourced from the multicentred Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) case-control study. In this report, a set of specific number coding represented the most common identified alleles for each studied gene, for example, HLA-A*24:02, HLA-B*51:01, HLA-C*06:02, HLA-DRB1*07:01, and HLA-DQB1*06:01. A significant deviation from the Hardy-Weinberg Equilibrium Proportion for HLA-A, HLA-C, and HLA-DRB1 was observed, and a combination of five common signals for each gene was reported. The generated genetic data is useful for scientists working to understand the role of genes in health and disease(s).

Hardy-Weinberg Equilibrium: a theorem used to state that allele and genotype frequencies in a population will remain constant from generation to generation in the absence of other evolutionary influences

[the_background] =>

Indians make up the third-largest ethnicity in Malaysia, with origins mainly from the southern part of India. Comprehensive genetic profiling of Malaysian Indians establishes a novel reference to appreciate the genetic makeup and changes that occur over time and are considered especially interesting in diasporic origins. This is because such data highlights the influence of geographical settings in the gene flow hypothesis. In addition, identification of genes commonly associated with specific genetic disorders or disease resistance across or within specific ethnicities adds to the global/general understanding of genetic influence in both health and disease, with consequences on disease prevention and treatment. Therefore, this report aims to provide genetic information of the Malaysian Indian community by using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods.

[the_sdg_impact] =>

The HLA genes are the most diverse in the human genome. The continuous study of the field has led to critical clinical applications and significant scientific impacts, including breakthroughs in understanding rheumatoid arthritis (RA), drug hypersensitivity, organ donor-recipient matching, and population genetics. Acknowledging the importance of HLA-genes in both health and disease, the authors have reported and established the common HLA-genes among 271 healthy Indians in Malaysia as a novel and additional reference in the Allele Frequencies Network Database (AFND). (SDG 3: Good health and well-being).

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0198885920302202 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/genes-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Genetic_9524062_1631086414.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.humimm.2020.04.004 [original_article_reference_fields] => Array ( [publication_title] => HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 271 Southeast Asia Indians from Peninsular Malaysia [journal_title] => Human Immunology [publisher] => Elsevier [year] => June 2020 [subject] => Medical; Immunogenetic; Immunology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [145] => WP_Post Object ( [ID] => 28125 [post_author] => 154 [post_date] => 2021-05-27 14:36:00 [post_date_gmt] => 2021-05-27 06:36:00 [post_content] => [post_title] => Investigation of Mutation Contributing to Insecticide Resistance in Backcrossed Wolbachia Mosquitoes [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => investigation-of-mutation-contributing-to-insecticide-resistance-in-backcrossed-wolbachia-mosquitoes [to_ping] => [pinged] => [post_modified] => 2024-01-13 15:06:38 [post_modified_gmt] => 2024-01-13 07:06:38 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28125 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HARSHMAN, Nancy Endersby [researchers_position] => School of BioSciences, University of Melbourne, Australia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/nancy.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => AHMAD, Noor Afizah [researchers_position_2] => Medical Entomology Unit, Institute for Medical Research, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/noor-f.png [researchers_profile_2] => https://www.researchgate.net/profile/Noor-Afizah-Ahmad [researchers_second_profile_2] => https://orcid.org/0000-0002-4101-4367 ) [original_article_reference] => [research_footprints] => Hardy–Weinberg equilibrium; pyrethroid resistance; sodium channel; odds ratios; genotype frequency; genetic background; single nucleotide polymorphism; aedes albopictus; anopheles gambiae; insecticide; aedes aegypti [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Poster-Wolba-New2-scaled.jpg [video] => [the_novelty] =>

This study identified the mutation that contributes to insecticide resistance in 2 different dengue vector mosquitoes, Aedes species. The study aimed at replicating the mutations responsible for the resistance found in wild type (from the field) in the laboratory reared Wolbachia mosquitoes through backcrossing. A cross-breed generation of mosquitoes was created by mating the mosquitoes from the field and the Wolbachia bacteria infected female colony from the laboratory and the mutations causing insecticide resistance was investigated across all species. The outcome of the research highlighted the resistance genotype and phenotype persisted in backcrossed populations in comparison with wild mosquitoes. The first mutation (F1534L) in Malaysia was also identified in one of the wild species, Ae. Albopictus which is an indication of increasing resistance towards the pesticide control methods being largely employed to contain the dengue situation in the country. The outcome of this study, thus, demonstrates that resistance mutations provide a survival advantage to Wolbachia Ae. aegypti mosquitoes, which must be maintained in laboratory lines by regular backcrossing, eventually help the sustainability of the Wolbachia mosquitoes in the field.

[the_background] =>

In Malaysia, an alternative method of dengue reduction is employed which comprises releases of Ae. aegypti mosquitoes infected with a bacterium, Wolbachia, found naturally in other insects. Wolbachia turns the mosquitoes into incompetent vectors so they do not transmit the disease. Regular backcrossing between laboratory grown Wolbachia mosquitoes and field mosquitoes preserve the pesticide resistance characteristics which provides a survival advantage to Wolbachia mosquitoes. However, Wolbachia mosquitoes are reared in the laboratory before release and must be able to survive in the field where they will encounter insecticides. Therefore, our study demonstrates benefits of crossing laboratory mosquitoes to those from the field over generations, so that the mosquito lines acquire field resistance characteristics, specifically in terms of mutations in the sodium channel gene.

[the_sdg_impact] =>

According to the statistics from the Ministry of Health, a total of 130 101 dengue cases and 182 deaths were reported in 2019. What’s more troubling is the percentage of increase of the cases and death rate compared to 2018, recording a 61.4% and 23.8% increase respectively. WHO estimates 390 million dengue virus infections annually with 70% occurrence in Asia and the staggering figures demonstrates the significance of efficient control methods to contain the situation. Two major setbacks of the existing dengue control method using chemicals are the potential toxicity to the environment and emergence of resistance to the pesticide treatment. In accordance with that, intervention using Wolbachia mosquitoes as an alternative will support two crucial goals of sustainable development by the United Nations, UNSGD 3, to promote good health and wellbeing and UNSDG 15, to protect the environment. Inevitably, this study paves way for the country and hopefully to the Asian region that is mainly affected by dengue to optimise this substitute biological method to prevent dengue infection.

[article_url] => https://bit.ly/48GPCUN [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Wolbachia-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Insecticide_9523953_1631086040.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://bit.ly/48GPCUN [original_article_reference_fields] => Array ( [publication_title] => Characterization of Sodium Channel Mutations in the Dengue Vector Mosquitoes Aedes aegypti and Aedes albopictus within the Context of Ongoing Wolbachia Releases in Kuala Lumpur, Malaysia [journal_title] => Insects [publisher] => MDPI [year] => August 2020 [subject] => Medical; Entomology; Dengue ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/g3hSsV_YHQA?si=rnNwjF6QbsOlab9p [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Screenshot-2024-01-02-104612.png [figures] => ) ) [146] => WP_Post Object ( [ID] => 28110 [post_author] => 154 [post_date] => 2021-05-27 14:12:42 [post_date_gmt] => 2021-05-27 06:12:42 [post_content] => [post_title] => Potential Remedy to Manage Obesity through the Consumption of Red Edible Seaweed Supplement [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => potential-remedy-to-manage-obesity-through-the-consumption-of-red-edible-seaweed-supplement [to_ping] => [pinged] => [post_modified] => 2024-01-13 15:06:18 [post_modified_gmt] => 2024-01-13 07:06:18 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28110 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => BALASUBRAMANIAM, Vimala [researchers_position] => Nutrition Metabolic & Cardiovascular Research Centre, Institute for Medical Research, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/vimala.png [researchers_profile] => https://www.researchgate.net/profile/Vimala-Balasubramaniam [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => edible seaweed; low-density lipoprotein anti-obesity; histopathology weight loss; high-density lipoprotein; insulin resistance; alkaline phosphatase; analysis of variance; ;weight gain; Rhodophyta; hematoxylin and eosin; eucheuma denticulatum; food intake; standard deviations; fat mass; in vivo; acute oral toxicity; chronic disease [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/graphical-abstract-Dr.-Vimala-1_001.png [video] => [the_novelty] =>

This study provided evidence on the anti-obesity properties of Eucheuma denticulatum, a red edible seaweed, in animal models. When fed with a high-fat diet and supplemented with E. denticulatum freeze-dried powder, rats showed an increased protective effect against visceral fat gain and lowered BMI and Lee index figures. Findings also showed improvement in insulin sensitivity and liver function and reduced dietary fat uptake when the metabolic biomarkers such as HOMA-IR, TG, glucose, leptin, ghrelin, and insulin were screened. In addition, a preliminary observation on acute toxicity as a result of this seaweed supplement suggests a maximum of 2000 mg kg-1 is safe to be consumed by the rats in a single oral administration. Based on the evidence shared, future research could explore options of including this species of red edible seaweed as a complementary treatment to manage obesity. However, further clinical research and evidence are required before such administration.

[the_background] =>

The major strategy for prevention and treatment of obesity is lifestyle modification, including diet control and physical exercise. Diet programs may produce weight loss over the short term, but maintaining weight loss frequently is difficult. There are several anti-obesity drugs commercially available including orlistat, rimonabant and sibutramine. However, the potential toxicity may limit their usage. Thus, continuous search for remedies with minimum side effects is paramount. E. denticulatum has shown to have health benefit properties such as anti-diabetic, anti-obesity, and antiinflammatory activities using in vitro models. At present, the overall effect on in vivo models and metabolic responses is relatively unknown. Thus, this study will further enhance scientific evidence and strengthen the claims of seaweed as a nutritious food.

[the_sdg_impact] =>

According to the statistics presented by World Health Organization (WHO), 1.9 billion adults worldwide were reportedly overweight in 2016, with 650 million were recognized as obese. The health consequences of being overweight and obese are dire as to increased risk for the development of cardiovascular diseases, diabetes, musculoskeletal disorders, and even some cancers. Therefore, to reduce the risk of premature deaths and disabilities caused by these non-communicable diseases resulting from obesity, this study presents E. denticulatum as a potential natural supplement to manage excessive diet-induced weight gain (SDG 3: Good health and well-being).

[article_url] => https://bit.ly/3NMS6ZB [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/seaweed.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Obesity_9523788_1631085544.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://bit.ly/3NMS6ZB [original_article_reference_fields] => Array ( [publication_title] => Effect of red edible seaweed Eucheuma denticulatum on diet-induced obesity in vivo [journal_title] => Journal of Applied Phycology [publisher] => Springer Nature [year] => February 2020 [subject] => Medical; Nutrition Metabolic; Cardiovascular ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/dYwUlbSSLHs?si=vVmi-NYlb43TQwqD [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Screenshot-2024-01-02-104234.png [figures] => ) ) [147] => WP_Post Object ( [ID] => 28077 [post_author] => 154 [post_date] => 2021-05-26 21:44:56 [post_date_gmt] => 2021-05-26 13:44:56 [post_content] => [post_title] => Estimating Hepatitis Infection Prevalence in Middle-income Country [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => estimating-hepatitis-infection-prevalence-in-middle-income-country [to_ping] => [pinged] => [post_modified] => 2024-01-13 15:07:19 [post_modified_gmt] => 2024-01-13 07:07:19 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28077 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MUHAMAD, Nor Asiah [researchers_position] => Sector Evidence Based in Healthcare, National Institute of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/asiah2.png [researchers_profile] => https://www.researchgate.net/institution/Ministry_of_Health_Malaysia [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => GHANI, Rimah Melati [researchers_position_2] => Sector Evidence Based in Healthcare, National Institute of Health, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/rimah2.png [researchers_profile_2] => https://www.researchgate.net/profile/Rimah-Ab-Ghani [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => hepatitis B virus; hepatitis C virus; confidence interval; hepatitis B; missing at random; odds ratios [graphic_abstract] => [video] => [the_novelty] =>

This study recognizes the importance of understanding the transmission patterns of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in the community. In 2016, The Malaysian Cohort (TMC) project was initiated to estimate the prevalence rate of HBV and HCV infection among the Malaysian adult population. Primarily, the study analyzed the presence of hepatitis B surface antigen (HBsAg), antibody to hepatitis B core antigen (anti-HBc), and antibody to hepatitis C virus (anti-HCV) in the blood sample to determine the seroprevalence of the infections. As a result, the prevalence of HBsAg, anti-HBc, and anti-HCV positivity among Malaysian adult population were 4%, 20%, and 0.3%, respectively. Thus, it was concluded that the seroprevalence of HBV infection in Malaysia is low and intermediate for HCV infection. With that said, male and rural residents were found to be at higher risk than the others. The study also elaborated the impact of geographical positioning of the community, lifestyle, cultural activity, and marital status as possible causes of the transmission. Ultimately, the data produced and factors identified concerning HBV and HCV infection transmission in Malaysia could be beneficial for policymakers to strategize the national immunization program and eradicate the diseases.

[the_background] =>

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections largely contribute to the rise of liver-related illnesses. Although the infections are preventable and treatable if diagnosed at an early stage, many are unaware that they are carriers of the viruses due to the asymptomatic nature of the infections. In Malaysia, the Ministry of Health (MoH) foresee a spike in the infection rates for HBV and HCV in the next 2 decades. In order to control this endemic threat, it is crucial for healthcare service providers and policymakers to understand the prevalence of HBV and HCV infections in the Malaysian community. However, there are no population-based studies conducted to date which could provide such data. Therefore, this study conducted a population-based study on HBV and HCV infection prevalence among the Malaysian adult population to improve disease control and early screening strategies.

[the_sdg_impact] =>

According to the World Health Organization (WHO), approximately 325 million people live with a viral hepatitis infection globally. It projects that an estimated 4.5 million premature deaths could be prevented in low- and middle-income countries by 2030 through structured immunization programs, early screening, and awareness campaigns. With Malaysia having an unclear estimation of the infected population, any hepatitis vaccination programs initiated may not provide the best outcome. Therefore, the data provided by this study would bring the Malaysian healthcare policymakers a step closer to understanding the prevalence of hepatitis infections in the community. With that, comprehensive policies and interventions can be drawn to improve the national vaccination program and significantly reduce the new hepatitis infections as aimed by WHO and UN SDG 3: Good health and well-being.

[article_url] => https://bit.ly/3TDwpiq [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/hepatitis-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Hepatitis_9524200_1631086906.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://bit.ly/3TDwpiq [original_article_reference_fields] => Array ( [publication_title] => Seroprevalence of hepatitis B virus and hepatitis C virus infection among Malaysian population [journal_title] => scientific reports [publisher] => Nature Portfolio [year] => December 2020 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/cYT3ALbaYgE?si=1i0WFYvhmsfrNb39 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Screenshot-2024-01-02-105258.png [figures] => ) ) [148] => WP_Post Object ( [ID] => 28057 [post_author] => 154 [post_date] => 2021-05-26 17:42:59 [post_date_gmt] => 2021-05-26 09:42:59 [post_content] => [post_title] => Factors Influencing Primary Healthcare Providers’ Perception towards Implementation of New Intervention [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => pre-intervention-perception-assessment-improves-acceptance-rate-of-new-healthcare-initiatives [to_ping] => [pinged] => [post_modified] => 2021-07-29 12:23:25 [post_modified_gmt] => 2021-07-29 04:23:25 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28057 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LOW, Lee Lan [researchers_position] => Institute For Health Systems Research, Ministry of Health Malaysia, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Assessing-.png [researchers_profile] => https://www.researchgate.net/profile/Lee-Lan-Low [researchers_second_profile] => https://orcid.org/0000-0002-9952-3017 ) [researchers_info_2] => Array ( [researchers_name_2] => ABDULLAH, Zalilah [researchers_position_2] => Centre for Health Policy Research Institute for Health Systems Research, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/2554.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0001-8100-3163 ) [original_article_reference] => [research_footprints] => Non-communicable diseases; healthcare clinic; nongovernmental organisations; service delivery; implementation research; primary healthcare; healthcare provider; qualitative [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/91F4DAAD34AB427089CF5115D9534D4B990.png [video] => [the_novelty] =>

The primary aim of this study is to examine the readiness of public primary healthcare providers in accepting changes in non-communicable disease (NCD) patient management intervention to be proposed by the Enhanced Primary Healthcare (EnPHC) initiative. By using the Consolidated Framework of Implementation Research (CFIR), the findings suggested that, at large, the healthcare providers are open and receptive towards changes. However, several concerns need to be addressed before implementing the initiative, namely shortage of staffing, high patient load, and existing clinic facilities. Furthermore, the varying cultural and local adaptations of the implementation and its management may also influence the healthcare providers’ perception of the changes. With this information, policymakers and clinic managers would be able to mold the intervention accordingly and allocate the resources efficiently to produce favorable outcomes of the EnPHC initiative; thus, improving the primary healthcare setting and NCD management.

[the_background] =>

Concerned by the rise of the non-communicable disease (NCD) burden in Malaysia, the Ministry of Health (MoH) proposed the Enhanced Primary Healthcare (EnPHC) initiative in selected public primary healthcare clinics. To design a feasible intervention model, baseline information on the perception of healthcare providers towards change is necessary, so is the understanding of the existing barriers in terms of human resources and infrastructure. Therefore, this study aimed to understand the current conditions of the local clinics and the challenges concerning the healthcare providers when it comes to accepting change, especially in NCD patient management.

[the_sdg_impact] =>

Apart from intending to reduce NCD-led premature mortality rate, UN SGD 3: good health and well-being, also emphasizes on improving the quality of essential healthcare system and services. To do so, it is crucial for policymakers to introduce supporting intervention strategies and initiatives, particularly to ensure NCD patients’ needs are met and well managed. Therefore, the findings of this study highlight the need to engage with healthcare service providers and recipients prior to the proposal of any intervention. By assessing the expectations, acceptance, and concerns of relevant parties, policymakers would be able to draft and implement a better and more practical national-level intervention, especially for healthcare services.

[article_url] => https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-019-4312-x [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/healthcare.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Assessing_6818018_1622021405.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s12913-019-4312-x [original_article_reference_fields] => Array ( [publication_title] => Assessing receptiveness to change among primary healthcare providers by adopting the consolidated framework for implementation research (CFIR) [journal_title] => BMC Health Services Research [publisher] => BMC [year] => July 2019 [subject] => Medical; Non Communicable Diseases ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [149] => WP_Post Object ( [ID] => 28040 [post_author] => 154 [post_date] => 2021-05-26 16:55:47 [post_date_gmt] => 2021-05-26 08:55:47 [post_content] => [post_title] => Protocol to Tailor the Person-centred Practice Framework to Fit Local Context [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => protocol-to-tailor-the-person-centred-practice-framework-to-fit-local-context [to_ping] => [pinged] => [post_modified] => 2024-01-13 15:07:37 [post_modified_gmt] => 2024-01-13 07:07:37 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28040 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => BALQIS-ALI, Nur Zahirah [researchers_position] => Centre for Health Outcomes Research, Institute for Health Systems Research, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/balqis.png [researchers_profile] => https://www.researchgate.net/profile/Nur-Balqis-Ali [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => average variance extracted; primary care clinic; exploratory factor analysis; structural equation modeling; composite reliability; healthcare provider; confirmatory factor analysis; factor analysis; ethics committee [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Flow-Chart-figure.png [video] => [the_novelty] =>

This study designed a protocol to adapt and validate the Person-Centred Practice Inventory-Staff (PCPI-S) questionnaire to measure person-centredness among the primary healthcare providers in Malaysia. The adaptation and validation process are suggested to be conducted in 4 stages: tool review, translation, pre-testing and cognitive interviewing, and psychometric evaluation, in the given order. By developing such a protocol, this study aims to translate the person-centred framework into practice through provision of a guide for learning and development in supporting person-centred care (PCC) for anyone who would like to implement the same practice in their local environment.

[the_background] =>

The person-centred practice framework by McCormack and McCance focused on the therapeutic relationship between healthcare providers and service users. Among the domains emphasized in the theoretical framework are the healthcare provider’s attributes, the care environment and processes, and person-centred practices and outcomes. Factors such as local culture and norms are essential for the effective delivery of PCC and evaluation tool designing. This study focuses on designing a comprehensive protocol to measure person-centredness among healthcare providers which is adapted and validated to fit the Malaysian primary healthcare context.

[the_sdg_impact] =>

Person-centred care has been acknowledged as a practice to replace the conventional medical and disease centered practice. The ultimate objective of the United Nations (UN) and World Health Organization (WHO) is to improve health outcomes by reducing mortality, ending epidemics, preventing and treating diseases, and refining care management quality (SDG 3: Good health and well-being). This study particularly focuses on catering the person-centred practice framework to fit into a developing country context in terms of culture, language, and norm to reflect on the practices of healthcare providers.

[article_url] => https://bit.ly/3tGtefd [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/protocol-2-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Protocol_6817045_1622018644.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://bit.ly/3tGtefd [original_article_reference_fields] => Array ( [publication_title] => Protocol for a cross-sectional study measuring person-centredness among healthcare providers in Malaysian primary care clinics: the adaptation and validation of the Person-Centred Practice Inventory-Staff (PCPI-S) Questionnaire [journal_title] => BMC Health Services Research [publisher] => BMJ [year] => March 2020 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/-6QtnPnMflM?si=JAwSn9mxlL8MKBqe [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Screenshot-2024-01-02-105608.png [figures] => ) ) [150] => WP_Post Object ( [ID] => 28020 [post_author] => 154 [post_date] => 2021-05-26 15:47:15 [post_date_gmt] => 2021-05-26 07:47:15 [post_content] => [post_title] => Effective Recruitment Strategies for Surveys Related to Primary Care [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => effective-recruitment-strategies-for-surveys-related-to-primary-care [to_ping] => [pinged] => [post_modified] => 2021-07-28 16:46:59 [post_modified_gmt] => 2021-07-28 08:46:59 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28020 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUSIN, Masliyana [researchers_position] => Institute for Clinical Research, National Institute of Health Malaysia, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Recruitment-.png [researchers_profile] => https://www.researchgate.net/profile/Masliyana-Husin [researchers_second_profile] => http://orcid.org/0000-0002-6553-6012 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => general practitioner; response rate; recruitment; continuing medical education; primary healthcare [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/save680.png [video] => [the_novelty] =>

How responsive are the doctors in Malaysia towards an international survey? This study showed that by adapting several strategies, favourable response rates could be obtained for surveys which require participation of doctors from public and private primary care settings in Malaysia. These strategies included having a national coordinator, sending out personalised invitations for recruitment, conducting face-to-face interview, rewarding non-monetary incentives and, last but not least, obtaining endorsement from professional associations, state health departments as well as private clinic managers. The details and reasons of non-responders were also recorded via a set of non-response questionnaires. In future studies, the non-respondents obtained are recommended to be used for making valid inferences about the target population.

[the_background] =>

The international QUALICOPC (Quality and Cost of Primary Care) study was conducted in various countries to evaluate the performance of primary care in the respective countries. In order to achieve their goals, data was collected from primary care doctors and patients via surveys. However, while attempting to engage the doctors, there are bound to be hurdles such as time constraint, confidentiality, lack of interest, and barriers set by ‘gatekeepers’. Thus, this study was carried out to describe the effective recruitment strategies, the response rates and the reasons for non-response of QUALICOPC study in Malaysia. The output of this research could facilitate future surveys involving primary care doctors.

[the_sdg_impact] =>

To improve the quality of health services rendered, research on primary care is necessary for the purpose of benchmarking. The research often requires data collection from both doctors and patients. This study has shared and discussed the effectiveness of several strategies which could increase the response rate in collecting the relevant data. Hence, its objective is well-aligned with UNSDG 9: Industry, Innovation & Infrastructure by helping to enhance scientific research.

[article_url] => https://www.cambridge.org/core/journals/primary-health-care-research-and-development/article/recruitment-and-participation-of-a-survey-in-a-publicprivate-primary-care-setting-experience-from-the-qualicopc-malaysia/D46D4E6091FA869F5FD459DDFB77F05A [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Recruitment-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Recruitment_6815891_1622014580.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1017/S1463423620000511 [original_article_reference_fields] => Array ( [publication_title] => Recruitment and participation of a survey in a public–private primary care setting: experience from the QUALICOPC Malaysia [journal_title] => Primary Health Care Research & Development [publisher] => Cambridge University Press [year] => November 2020 [subject] => Medical; Primary Health Care ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [151] => WP_Post Object ( [ID] => 28003 [post_author] => 154 [post_date] => 2021-05-26 15:24:17 [post_date_gmt] => 2021-05-26 07:24:17 [post_content] => [post_title] => Suboptimal BP Control and Hypertension Care by Malaysia’s Public Primary Care Clinics [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => suboptimal-bp-control-and-hypertension-care-by-malaysias-public-primary-care-clinics [to_ping] => [pinged] => [post_modified] => 2021-07-29 09:32:10 [post_modified_gmt] => 2021-07-29 01:32:10 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=28003 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LIM, Ming Tsuey [researchers_position] => Healthcare Statistics Unit, Clinical Research Malaysia, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/testing2.png [researchers_profile] => https://www.researchgate.net/profile/Ming-Lim-8 [researchers_second_profile] => https://orcid.org/0000-0001-5275-9236 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => primary care clinic; calcium channel blockers; blood pressure; risk factor; clinical practice; chronic kidney disease [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/IMG_3192-scaled.jpg [video] => [the_novelty] =>

Is the current management of hypertensive patients feasible and effective enough? By examining patients’ medical records between 1st November 2016 and 30th June 2019, this study showed that there was hardly any improvement in the hypertensive care in Malaysia’s public primary care clinics compared to how it was in the previous decade. The blood pressure (BP) control was found to be suboptimal in those clinics. There were gaps between guidelines and actual clinical practice in the process of care for hypertension management which has a huge room for improvement. The authors suggested examining the optimal coordination, consultation, counseling and good communication skills for implementing effective management in future studies.

[the_background] =>

The last known evaluation for the process of care for hypertension in Malaysia was conducted about a decade ago. Meanwhile, most of the evaluations focussed on the burden of hypertension in the Malaysian population. That being said, there is a very limited number of reported evaluations on process of care and BP control. Hence, this study was conducted to investigate the latest process of care for hypertension management and to examine the association between the process and BP control among hypertensive patients in Malaysia’s public primary care clinics. The outcome serves as a good reference in overcoming the current suboptimal management of hypertensive patients.

[the_sdg_impact] =>

In 2015, 1.13 billion people worldwide suffered from hypertension and two-thirds of them were living in low- and middle-income countries. Less than 1 out of 5 people with hypertension have the problem under control (source: WHO). The findings of this study would be beneficial to create and increase hypertension awareness and improve its management of hypertension among the patients in public clinics as hypertension was largely managed in this healthcare setting. In return, it contributes to risk reduction and better management of national health which is part of the targets of UNSDG 3: Good Health & Well-Being.

[article_url] => https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237083 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/hypertension-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/hypertension_6815501_1622013399.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1371/journal.pone.0237083 [original_article_reference_fields] => Array ( [publication_title] => Quality of hypertension management in public primary care clinics in Malaysia: An update [journal_title] => PLOS One [publisher] => PLOS [year] => August 2020 [subject] => Medical; Hypertension ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [152] => WP_Post Object ( [ID] => 27966 [post_author] => 154 [post_date] => 2021-05-26 12:47:31 [post_date_gmt] => 2021-05-26 04:47:31 [post_content] => [post_title] => Rising Burden of Dementia Exerts Heavy Toll on Caregivers [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => rising-burden-of-dementia-exerts-heavy-toll-on-caregivers [to_ping] => [pinged] => [post_modified] => 2021-07-05 15:11:20 [post_modified_gmt] => 2021-07-05 07:11:20 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27966 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => Shubash Shander Ganapathy [researchers_position] => Survey Research Centre, Institute for Public Health, National Institutes of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/shubash.png [researchers_profile] => https://www.researchgate.net/profile/Shubash-Ganapathy [researchers_second_profile] => https://orcid.org/0000-0003-0942-6617 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => social support; quality of life; affirmative action; dementia; public health; caregivers; longitudinal study; systematic review; activities of daily living [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Graphical-Abstract-Prevalence-of-dementia-and-quality-of-life-of-caregivers-of-people-living-with-dementia-in-Malaysia.png [video] => [the_novelty] =>

What is the prevalence of dementia in Malaysia and how does it affect the life of caregivers involved? This study reported that the prevalence of dementia in Malaysia was 8.5 % among people of age 60 years and above, with the majority of them being women. A larger portion of dementia patients are also found to have no formal education and living in rural areas. As a whole, the prevalence rate is considered high since it exceeded the global dementia prevalence of 5 to 8 % as estimated by WHO. The findings suggested that the quality of life (QoL) of caregivers of people living with dementia (PLwD) depends mainly on the functional capacity of the PLwD and the availability of social support. Since these caregivers do not socialize much, physicians attending to the PLwD are encouraged to inform and educate the caregivers as part of establishing a solid support system.

[the_background] =>

Malaysia is set to become an aging society by 2030 when 15 % of its population will be 60 years old and above (Source: Department of Statistics). Such a trend implies that the number of dementia cases will increase accordingly. In order to be well-prepared to address this, it is necessary to understand the needs and support needed to be given to the caregivers of PLwD, as the QoL of the caregivers will in turn affect the well-being of PLwD. Other than determining the prevalence of dementia, this study aimed to understand which factors have the most influence on caregivers’ QoL and discusses ways to improve the QoL of caregivers of PLwD.

[the_sdg_impact] =>

Dementia is one of the major causes of disability and dependency among older people worldwide. Its impact is often overwhelming for both PLwD and their families as well as caregivers. The outcome of this research proved that an urgency is needed in attending to the burden of care associated with the increasing prevalence of dementia and improving the QoL of caregivers of PLwD. Hence, this research is well-aligned with UNSDG 3: Good Health & Well-being in ensuring healthy lives and promoting well-being.

[article_url] => https://onlinelibrary.wiley.com/doi/10.1111/ggi.14031 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/dementia-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/dementia_6812858_1622004098.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1111/ggi.14031 [original_article_reference_fields] => Array ( [publication_title] => Prevalence of dementia and quality of life of caregivers of people living with dementia in Malaysia [journal_title] => Geriatrics & Gerontology International [publisher] => Wiley Publishing [year] => December 2020 [subject] => Medical; Non Communicable Diseases ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [153] => WP_Post Object ( [ID] => 27946 [post_author] => 154 [post_date] => 2021-05-26 11:26:35 [post_date_gmt] => 2021-05-26 03:26:35 [post_content] => [post_title] => Latest Prevalence & Risk Factors of Chronic Kidney Disease in Malaysia [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => latest-prevalence-risk-factors-of-chronic-kidney-disease-in-malaysia [to_ping] => [pinged] => [post_modified] => 2024-01-13 15:04:50 [post_modified_gmt] => 2024-01-13 07:04:50 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27946 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SAMINATHAN, Thamil Arasu [researchers_position] => Centre for Non Communicable Diseases Research (CNCDR), Institute of Public Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Kidney-.png [researchers_profile] => https://www.researchgate.net/profile/Thamil-Saminathan [researchers_second_profile] => https://orcid.org/0000-0002-8342-0777 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => living quarters; risk factor; estimated glomerular filtration rate; body mass index; clinical practice guidelines; blood pressure; public health; diabetes mellitus; glomerular filtration rate; confidence intervals; prevalence; kidney disease; chronic kidney disease [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/CKD-Graphical-Abstract-IES-1.png [video] => [the_novelty] =>

What is the latest prevalence of chronic kidney disease (CKD) in Malaysia? This study reported that the CKD prevalence in Malaysia increased from 9.07% (2011) to 15.48% (2018). The factors associated with CKD were hypertension, diabetes mellitus, increasing body mass index (BMI), and increasing age. The results were derived from several significant metrics including estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (uACR) of a total 1,047 adults throughout Malaysia. Studies to re-assess the trends in CKD prevalence should be carried out regularly in the future in order to evaluate the effectiveness of effort taken to prevent and treat CKD.

[the_background] =>

In Malaysia, 37,781 patients were on renal replacement therapy by the end of 2016. Such a phenomenon posed a significant burden to the national healthcare budget. Meanwhile, there was no regular update on the prevalence of CKD in Malaysia. Hence, it is necessary to have that information so as to prevent, treat and improve the healthcare of CKD patients. This study was carried out to investigate the current prevalence of CKD among adults in Malaysia and its associated risk factors. The outcome could guide the Ministry of Health to strategise feasible plans and budgets to address CKD.

[the_sdg_impact] =>

10% of the population worldwide is affected by CKD which is a global health crisis (source: WHO). Nonetheless, with early diagnosis and treatment, it's possible to delay or stop the progression of kidney disease. By reporting the increasing trend of CKD prevalence and the potential associated risk factors, this study showed the policymakers the urgency to deal with the current state of CKD in Malaysia. In other words, it strengthens the capacity of Malaysia for early warning, risk reduction and management of CKD. Thus, this study helps to realize UNSDG 3: Good Health & Well-being.

[article_url] => https://bit.ly/41FlMO1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Kidney-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Kidney_6811343_1621999319.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://bit.ly/41FlMO1 [original_article_reference_fields] => Array ( [publication_title] => Prevalence of chronic kidney disease and its associated factors in Malaysia; findings from a nationwide population-based cross-sectional study [journal_title] => BMC Nephrology [publisher] => BMC [year] => August 2020 [subject] => Medical; Non Communicable Diseases ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/zOkcMCzvd3E?si=Rk2Sn3axRwG3KSzc [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Screenshot-2024-01-02-102842.png [figures] => ) ) [154] => WP_Post Object ( [ID] => 27923 [post_author] => 154 [post_date] => 2021-05-26 10:45:17 [post_date_gmt] => 2021-05-26 02:45:17 [post_content] => [post_title] => Identifying the Impact of Kiddie Cigarette Packs on Smoking [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => identifying-the-impact-of-kiddie-cigarette-packs-on-smoking [to_ping] => [pinged] => [post_modified] => 2024-01-13 15:07:55 [post_modified_gmt] => 2024-01-13 07:07:55 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27923 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HALIZAH MAT, Riffin [researchers_position] => Institute for Public Health, National Insitutes of Health, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Cigarette.png [researchers_profile] => https://www.researchgate.net/profile/Halizah-Mat-Rifin [researchers_second_profile] => https://orcid.org/0000-0002-5067-5677 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Cigarette; cigarette stick; confidence interval; ;tobacco control; packaging; smoking prevalence; illicit cigarette; randomised controlled trials; systematic review; tobacco industry; cigarette pack; tobacco use; chronic disease [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Graphical-abstract-Kiddie-packs.jpg [video] => [the_novelty] =>

Does the packaging size of cigarettes help in reducing cigarette consumption? This protocol article has proposed a comprehensive method to conduct a systematic review focussing on the potential impact of kiddie-size cigarette packaging on smoking habits and patterns. The method involves reviewing original articles discussing the impact of kiddie packs on smoking sourced from a range of databases with no restrictions on the publication date, language, and study designs. The findings include the initiation of smoking and urge to buy cigarettes in the general population, and the attempt to reduce cigarette consumption among current smokers.

[the_background] =>

Small/kiddie cigarette packs are two-edge swords whereby they might help heavy smokers to quit smoking but, on the other hand, encourage minor and lower-income consumers to smoke due to their lower prices. After kiddie packs were banned in several countries, the tobacco industry has been trying to reintroduce kiddie packs by claiming that doing this can be a solution for the surge of contraband cigarettes. To resolve the contradicting intentions, an evidence-based conclusion is needed for the actual impact of kiddie-size cigarette packaging. Hence, this protocol article proposes the first-ever systematic review to be conducted to identify the impact of kiddie packs on patterns of tobacco consumption. With the proven impact, the review serves as a solid reference for governments to control the distribution of kiddie packs according to the effort in lowering the consumption of tobacco.

[the_sdg_impact] =>

WHO states that tobacco kills up to half of its users, which is more than 8 million people each year. Therefore, tobacco is undeniably one of the biggest public health threats which needs to be addressed. However, the actual impact of kiddie cigarette packs on tobacco consumption has yet to be concluded. This article proposes a practical protocol to identify the impact of kiddie packs on smoking. As one of SDG 3 aims is to reduce premature mortality on NCDs, the evidence-based study on the kiddie packs is necessary to help the policymakers in regulating kiddie packs to control tobacco consumption.

[article_url] => https://bit.ly/3vgvmdX [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Cigarette-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Cigarette_6810788_1621997186.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://bit.ly/3vgvmdX [original_article_reference_fields] => Array ( [publication_title] => A systematic review protocol on small/kiddie cigarette packaging size and its impact on smoking [journal_title] => Systematic Reviews [publisher] => BMC [year] => January 2020 [subject] => Medical; Non Communicable Diseases ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/gqQesOnK53I?si=KKYSbQrwAWSZJuvD [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Screenshot-2024-01-02-105910.png [figures] => ) ) [155] => WP_Post Object ( [ID] => 27748 [post_author] => 154 [post_date] => 2021-05-17 11:08:50 [post_date_gmt] => 2021-05-17 03:08:50 [post_content] => [post_title] => Gene Regulatory Network as a Tool to Understand Vertebrate Head Evolution [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => gene-regulatory-network-as-a-tool-to-understand-vertebrate-head-evolution [to_ping] => [pinged] => [post_modified] => 2021-09-13 10:21:47 [post_modified_gmt] => 2021-09-13 02:21:47 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27748 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YASUOKA, Yuuri (安岡有理) [researchers_position] => Center for Integrative Medical Sciences, RIKEN, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Gene-.png [researchers_profile] => https://www.researchgate.net/profile/Yuuri-Yasuoka-2 [researchers_second_profile] => https://orcid.org/0000-0003-2295-9506 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Lim1; xenopus laevis; cephalochordate; cis-regulatory module; genomics; branchiostoma; untranslated region; vertebrate; Williams-beuren syndrome; chordin; spemann-mangold organizer; gene regulatory network [graphic_abstract] => [video] => [the_novelty] =>

Gene regulatory networks specific to vertebrates illustrate that rearrangement of cis-regulatory modules contributes to the evolution of genetic control for vertebrate development. In this study, researchers compared cis-regulatory modules of vertebrate organizer genes between the amphioxus (Branchiostoma) and the frog (Xenopus) model to understand the evolution of vertebrate head development. In summary, it was found that the goosecoid gene supresses the trunk genes in the vertebrate’s head, which results in the evolution of the vertebrate head with anteriorly enlarged brain. Based on the findings, a model was proposed that the vertebrate goosecoid gene acquired the cis-regulatory module to be activated continuously in the anterior mesoderm of the vertebrate lineage. However, the model should be tested in the future by assays for potential DNA sequence elements using amphioxus models as previously done by other researchers in the genetic control field.

[the_background] =>

Based on gene expression patterns and neuroanatomy, the rostral part of amphioxus central nervous system is postulated to be homologous to that of vertebrates, suggesting that the vertebrate brain was acquired on a foundation already present in the ancestral chordate, instead of through addition of a new part anterior to the notochord. Recent arguments strongly go against the “new head” theory, where the neural crest and neurogenic placodes are unique to vertebrates, and most of the vertebrate forebrain are neomorphic structures. To address this, research focused on head organizer genes in vertebrates, otx2, lim1/lhx1, goosecoid, and chordin, by comparing their gene regulatory networks during head formation in Branchiostoma and Xenopus to further evaluate how the chordate head evolved.

[the_sdg_impact] =>

A 2019 report by the United Nations highlighted that around 1 million animal and plant species are now threatened with extinction, many within decades. The findings of the report showed a decline of 20% in the average abundance of native species in most major land-based habitats, more than 40% of amphibian species, almost 33% of reef-forming corals and more than a third of all marine mammals. As presented in this study, an in-depth understanding of the genetic make-up of animals would encourage more innovative conservation and protection efforts to be implemented. Ultimately, the outcome aligns well with UN SDG 14: Life below water for species like amphioxus and SDG 15: Life on Land when the technique is applied for other organisms.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0143-1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Gene-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/gene_6583905_1621220388.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0143-1 [original_article_reference_fields] => Array ( [publication_title] => Evolution of cis-regulatory modules for the head organizer gene goosecoid in chordates: comparisons between Branchiostoma and Xenopus [journal_title] => Zoological Letters [publisher] => BMC [year] => August 2019 [subject] => Zoology; Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/lASDyD0EHhk [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Gene-Regulatory-Network-as-a-Tool-to-Understand-Verterbrate-Head-Evolution.mp4_snapshot_00.01_2021.08.13_16.37.39.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/gene-4.png ) ) [156] => WP_Post Object ( [ID] => 27719 [post_author] => 154 [post_date] => 2021-05-16 19:29:59 [post_date_gmt] => 2021-05-16 11:29:59 [post_content] => [post_title] => Recapitulation Pattern in Chromatin Accessibility During Vertebrate Embryogenesis [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => recapitulation-pattern-in-chromatin-accessibility-during-vertebrate-embryogenesis [to_ping] => [pinged] => [post_modified] => 2021-09-13 11:56:08 [post_modified_gmt] => 2021-09-13 03:56:08 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27719 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => UESAKA, Masahiro (上坂将弘) [researchers_position] => Center for Biosystems Dynamics Research, RIKEN, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/embryogenesis-.png [researchers_profile] => https://www.researchgate.net/profile/Masahiro-Uesaka [researchers_second_profile] => https://orcid.org/0000-0002-2927-4860 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Recapitulation; gene expression; embryogenesis; gallus gallus; C. elegans; parallelism; expression profile; ATAC-seq; regulatory element; developmental stage [graphic_abstract] => [video] => [the_novelty] =>

This study provided molecular-level evidence that the evolutionarily newer genomic regions become more accessible sequentially at later developmental stages of the embryo. Three specimens from vertebrate species were used, namely the mouse, chicken, and medaka embryos, to map out accessible chromatin regions (ACRs). Observations proved that ATAC-seq (an assay for transposase-accessible chromatin using sequencing) used to mark active regulatory regions provided a reliable accessible chromatin landscape and clear estimation of chromatin accessibility at different development stages of whole-embryo. The outcome showed maximum ACRs signals with younger evolutionary ages emerging at later developmental stages; thus, confirming a recapitulation pattern in chromatin accessibility at later stages in the mid-to-late embryogenesis of the vertebrates.

[the_background] =>

Recapitulation is a hypothetical concept that assumes animal development proceeds along its own evolutionary history, sequentially developing from more ancestral features to more derived ones. Although this concept predicts an evolutionary tendency of animal development, the recent transcriptomic studies have not supported the recapitulation throughout embryogenesis. They showed that the mid-embryonic period, rather than the earliest one, is the most ancestral, or most evolutionarily conserved. Nonetheless, this mid-embryonic conservation does not rule out the possibility that embryogenesis after the mid-embryonic period would still show the recapitulation pattern. Therefore, this study tests the possibility by looking into active gene regulatory regions throughout the embryonic development of selected vertebrate species.

[the_sdg_impact] =>

In-depth knowledge on animal evolution and development in terms of genes and morphology is key to understanding the survival and adaptability behaviors of the organism. The findings of this study contribute to the existing theories and hypotheses about embryonic development and the similarity with its ancestral evolution patterns. The information gathered could benefit conservation efforts both for aquatic and terrestrial animals, genetic modification of poultry animals, and many more (UNSDG14: Life below water and UNSDG15: Life on land).

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0148-9 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/embryogenesis-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/embryogenesis_6570887_1621163661.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0148-9 [original_article_reference_fields] => Array ( [publication_title] => Recapitulation-like developmental transitions of chromatin accessibility in vertebrates [journal_title] => Zoological Letters [publisher] => BMC [year] => November 2019 [subject] => Zoology; Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/mPNn2lTLVoU [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Recapitulation-pattern-in-chromatin-accessibility-during-vertebrate-embryogenesis.mp4_snapshot_00.01_2021.06.02_15.51.33.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/embryogenesis-4.png ) ) [157] => WP_Post Object ( [ID] => 27420 [post_author] => 154 [post_date] => 2021-05-05 14:27:00 [post_date_gmt] => 2021-05-05 06:27:00 [post_content] => [post_title] => A Climate-based Dengue Forecast Model [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => a-climate-based-dengue-forecast-model [to_ping] => [pinged] => [post_modified] => 2021-09-13 11:57:45 [post_modified_gmt] => 2021-09-13 03:57:45 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27420 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHUANG, Ting-Wu (莊定武) [researchers_position] => Department of Molecular Parasitology and Tropical Diseases, Taipei Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/climate.png [researchers_profile] => https://www.researchgate.net/profile/Ting-Wu-Chuang [researchers_second_profile] => https://orcid.org/0000-0001-8359-8172 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => multivariate ENSO index; aedes aegypti; diurnal temperature range; autocorrelation function; antibody-dependent enhancement; extrinsic incubation period; partial autocorrelation function; Akaike Information Criterion; sea surface temperature; dengue fever; el nino southern oscillation [graphic_abstract] => [video] => [the_novelty] =>

To establish a better dengue early warning system, efforts have led Taiwanese epidemiologists to develop a dengue forecasting model using climate parameters. The local and regional weekly minimum temperature has been identified as a reliable indicator for predicting disease transmission. In Southern Taiwan, Kaohsiung City and Tainan City are among the two major dengue hotspots. Analysis of the reported dengue cases and climatic conditions of these hotspots showed that temperatures higher than 23˚C is optimal for mosquito development and virus propagation. The effects are predicted to last up to 10-15 weeks. Moreover, the study also looked into the influence of climate variations caused by El Nino-Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) on dengue transmission. As a result, it is suggested to consider the effects of seasonal climate phenomena as part of dengue incidence forecasting. By extension, a similar climate-based forecasting model could be applied to predict the risks of other vector-borne disease transmissions such as Zika and Chikungunya.

[the_background] =>

Existing dengue control prevention and management are only initiated upon receiving reports of locally acquired human cases. Thus, making it a step too late in controlling the vector propagation and virus transmission from the very beginning. A number of past studies have associated factors such as temperature, relative humidity, and precipitation with dengue transmission. However, there has been no firm prediction model available to give out early warning alerts. Alike previous literature, this study intends to further analyze the influence of climate variability on the disease transmission pattern. The findings are to be used to develop a dengue forecast model effective for early warnings, disease control and preventive measures.

[the_sdg_impact] =>

In recent decades, the rate of dengue infection worldwide has increased significantly, and around 100-400 million infections are reported each year, as documented by WHO in 2020. Implementing improved outbreak prediction and detection through coordinated epidemiological and entomological surveillance is among the few ways to effectively reduce dengue morbidity. The climate-based dengue forecast model developed in this study allows public health authorities and policymakers to initiate timely preventive measures to reduce the rate of dengue infection as well as prevent a higher death toll. Essentially, the development of such a disease forecast model would contribute towards the realization of UNSDG 3: Good Health and Well-Being, which aims to reduce premature mortality from non-communicable diseases through prevention and treatment. Likewise, the contribution of the tool is also to strengthen resilience and adaptive capacity to climate-related hazards, not just in Taiwan but also other countries facing similar threats. This, in turn, aids the fulfilling of some crucial targets of the United Nation’s Sustainable Development Goals 13 (Climate Action) and 17 (Partnerships for the Goals).

[article_url] => https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178698 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/climate.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/climate_6315602_1620195190.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1371/journal.pone.0178698 [original_article_reference_fields] => Array ( [publication_title] => Effects of local and regional climatic fluctuations on dengue outbreaks in southern Taiwan [journal_title] => PLOS One [publisher] => PLOS [year] => June 2017 [subject] => Molecular Parasitology; Tropical Diseases; Dengue ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/climate4.png ) ) [158] => WP_Post Object ( [ID] => 27376 [post_author] => 154 [post_date] => 2021-05-03 10:31:41 [post_date_gmt] => 2021-05-03 02:31:41 [post_content] => [post_title] => Adoption of Mobile Shopping in Developing Countries [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => adoption-of-mobile-shopping-in-developing-countries [to_ping] => [pinged] => [post_modified] => 2021-11-08 16:00:27 [post_modified_gmt] => 2021-11-08 08:00:27 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27376 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PHONG, Nguyen Dong [researchers_position] => President of UEH, University of Economics Ho Chi Minh City, Vietnam [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/23s.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => KHOI, Nguyen Huu [researchers_position_2] => Economics Faculty, Nha Trang University, Vietnam [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/12s.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0002-6253-7263 ) [original_article_reference] => [research_footprints] => predictive power; theory of reasoned action; structural equation model; trust; effect size; confirmatory factor analysis; mobile shopping; composite reliability; perceived risk; self-efficacy [graphic_abstract] => [video] => [the_novelty] =>

This study proposed a comprehensive theoretical model by integrating additional variables into the theory of reasoned action (TRA) to understand consumer intention in adopting mobile shopping. Consistent with past literature, TRA served as a good predictive model in understanding the mobile shopping adoption among people of Vietnam. By integrating perceptions of promotion and barrier factors, the study increased the strength of TRA from 19% to 61% in terms of explaining the intention of Vietnamese consumers in adopting mobile shopping. The promotion factors taken into account in building this framework were attitude, norm, self-efficacy, and trust, which showed positive influence on mobile shopping adoption behavior. Perceived risk and cost are among the barriers that holds consumer back from using mobile technologies when shopping. Overall, the outcome of this study is beneficial for business managers and marketers to understand customer drive and concerns and better cater their mobile business strategies and investments.

[the_background] =>

Platforms such as Amazon.com and ebay have altered the way people shopping for almost 3 decades by bringing it online. In recent years, mobile shopping has become a trend mainly due to the mobile technology advancement and convenience. With that, many researchers have looked into the adoption of this mode of shopping through the lenses of technological driving factors which are mostly centered in developed countries. In developing countries like Vietnam, the technological infrastructure for electronic and mobile shopping are yet to mature up to the extend. Moreover, there are a number of cultural norms that comes into play when consumers consider adopting mobile shopping. Therefore, this study aims to explore and understand how and why Vietnamese consumers decide to use mobile shopping. Hopefully, these findings could contribute to the structuring of appropriate strategies that supports mobile shopping services either from the business perspective or policymaking.

[the_sdg_impact] =>

The penetration rate of e-commerce in developing countries can be said as slow due to multiple factors, mainly in terms of infrastructure availability. Unlike developed countries, cultural norms and lack of awareness or understanding towards digital platforms can be a huge deal-breaker when consumers in developing countries consider adopting mobile app based services such as mobile shopping or even mobile banking, telehealth and online learning. Hence, the proposed framework in this study allows business owners and policymakers to better understand consumer concerns. This, as intended in UNSDG 9: Industry, innovation and infrastructure, promotes the development of quality, reliable, sustainable and resilient infrastructure to support economic development with a focus on affordable and equitable access for all.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-05-2018-0012/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/mobile-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/mobile_6263733_1620005287.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-05-2018-0012 [original_article_reference_fields] => Array ( [publication_title] => Factors affecting mobile shopping: a Vietnamese perspective [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => September 2018 [subject] => Business; Economics; Marketing ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/BC-m0_n5cB4 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/10.mp4_snapshot_00.01_2021.07.14_12.24.39.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/mobile.png ) ) [159] => WP_Post Object ( [ID] => 27353 [post_author] => 154 [post_date] => 2021-05-02 19:47:33 [post_date_gmt] => 2021-05-02 11:47:33 [post_content] => [post_title] => A Guide to Improve Risk Disclosure Compliance among Financial Institutions in Developing Countries [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => a-guide-to-improve-risk-disclosure-compliance-among-financial-institutions-in-developing-countries [to_ping] => [pinged] => [post_modified] => 2021-12-02 12:58:05 [post_modified_gmt] => 2021-12-02 04:58:05 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27353 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NKUUTU, Geofrey [researchers_position] => Management Science, Makerere University Business School, Uganda [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/geofrey.png [researchers_profile] => https://www.researchgate.net/profile/Nkuutu-Geofrey [researchers_second_profile] => https://orcid.org/0000-0002-9560-1380 ) [researchers_info_2] => Array ( [researchers_name_2] => NTAYI, Joseph Mpeera [researchers_position_2] => Procurement and Logistics, Makerere University Business School, Uganda [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/governance-.png [researchers_profile_2] => https://www.researchgate.net/profile/Joseph-Ntayi [researchers_second_profile_2] => https://orcid.org/0000-0003-3223-2036 ) [original_article_reference] => [research_footprints] => structural equation; corporate governance; Uganda; International Financial Reporting Standards; empirical evidence; financial institution [graphic_abstract] => [video] => [the_novelty] =>

For the first time, this study provides a closer look on how the board governance quality (BGQ) mechanism of financial institutions can impact the risk disclosure compliance (RDC) in Uganda. The evidence collected from financial statement analysis and surveys showed that the overall RDC level in Ugandan financial institutions is low, thus, suggesting a weak BGQ in place. Among the factors identified to have a strong influence on RDC levels in the financial institutions are ownership type, firm size, and board size. In order to enhance the transparency levels in these institutions, especially in terms of risk communication, governance board activity, independence, communication, and expertise should be improved. The findings of this study could serve as a useful guideline for policymakers to improve risk information regulation and quality in the given country.

[the_background] =>

Transparency in disclosing risk information has huge implications, one of which is allowing investors to assess market returns and risk profiles prior to making essential financial decisions. Having said that, there are limited literature available that provides a clearer picture of such risk information management practices in developing countries like Uganda. Furthermore, an analysis on the Ugandan RDC suggested poor compliances with several of the country’s main governance board of the financial institutions. Therefore, this study aims to understand the BGQ mechanisms of Ugandan financial institutions in influencing RDC so that the policymakers could improve the existing board governance framework and policy structure.

[the_sdg_impact] =>

In the chase towards sustainable finance, there are a number of indicators and standards to follow, such as ESG, SDG, Green Finance, etc. To fulfil these indicators, bank and financial institutions are required to develop and implement new frameworks and regulations. In addition, it is even more crucial for financial institutions to practice transparency when communicating risks and complying to the set rules. Therefore, in line with the notion of developing an effective, accountable and transparent institutions as suggested in UNSDG 16: Peace, justice and strong institutions, policymakers of developing countries could utilize the findings of this study to enhance respective financial institutions and governance board quality.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-04-2020-0036/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/governance-3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/governance_6253687_1619955713.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-04-2020-0036 [original_article_reference_fields] => Array ( [publication_title] => Board governance quality and risk disclosure compliance among financial institutions in Uganda [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => October 2020 [subject] => Business; Economics; Finance ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/OE0OnR80qBI [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Article-9.mp4_snapshot_00.01_2021.08.04_09.49.56.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/governance-2.png ) ) [160] => WP_Post Object ( [ID] => 27332 [post_author] => 154 [post_date] => 2021-05-02 19:29:00 [post_date_gmt] => 2021-05-02 11:29:00 [post_content] => [post_title] => Unique Employment and Investment Practices to Drive Manufacturing Industry Growth [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => unique-employment-and-investment-practices-to-drive-manufacturing-industry-growth [to_ping] => [pinged] => [post_modified] => 2021-09-26 17:52:28 [post_modified_gmt] => 2021-09-26 09:52:28 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27332 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KIM, Sangho [researchers_position] => College of International Management, Ritsumeikan Asia Pacific University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/kim-sang.png [researchers_profile] => https://www.researchgate.net/profile/Sangho-Kim-3 [researchers_second_profile] => https://orcid.org/0000-0002-0440-2002 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => information technology; short run; production; long run; dynamic structure; manufacturing industry [graphic_abstract] => [video] => [the_novelty] =>

This research provides better knowledge of the unique dynamic structure of the Japanese manufacturing industry by looking at the production structure and industrial policies. When the dynamic production structure is analyzed using the adjustment cost approach, it is proved that the adjustment coefficients for labor and capital are very low, about 0.2% annually only. Such is the consequence of lifetime employment contract and slow and carefully considered investment decision making. The results of the research also emphasized the influence of time horizon on short term output supply and factor demand elasticities, thus, urging policymakers to consider it as a factor to assess policy impacts accurately.

[the_background] =>

Japanese manufacturing industry, known for its continuous and relentless transformation, attracted the attention of many industrial leaders. Their unique practices in perfecting their products over the long haul includes a distinguished employment term and cautious investment strategy. Nevertheless, the industrial policies drafted by the government are also drivers of the manufacturing industry growth. Since there is lack of literature evidence on the implications of these practices, this study aims to explain the production structure and manufacturing investment patterns of the Japanese industry as well as the policies that complement the practices.

[the_sdg_impact] =>

One of the targets of the 8th United Nations’ Sustainable Development Goal is to achieve higher levels of economic productivity through diversification, technological upgrading and innovation, including through a focus on high-value added and labour-intensive sectors. In Japan, the manufacturing industry is among the capital- and skilled labor-intensive sectors which has constantly gone through transformation to cope with economic setbacks and evolution. In order to continue such growth and to improve the decision-making process of the industrial owners as well as the government, it is crucial for the findings of this research to be considered. With that, better employment and investment efforts could be adopted. Apart from that, other countries could also learn the best practices to improve their respective manufacturing industries and economic productivity.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-12-2019-0123/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Dynamic-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Dynamic_6253556_1619954683.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-12-2019-012 [original_article_reference_fields] => Array ( [publication_title] => Dynamic factor demand in the Japanese manufacturing industry [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => February 2020 [subject] => Business; Economics; Finance ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/C9YS2PfO7-o [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Article-8.mp4_snapshot_00.02_2021.07.26_17.00.35.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/Dynamic-2.png ) ) [161] => WP_Post Object ( [ID] => 27311 [post_author] => 154 [post_date] => 2021-05-02 19:14:47 [post_date_gmt] => 2021-05-02 11:14:47 [post_content] => [post_title] => Taxation and Stock Market Index Volatility [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => tax-reformation-and-stock-market-index-volatility [to_ping] => [pinged] => [post_modified] => 2021-09-26 17:49:13 [post_modified_gmt] => 2021-09-26 09:49:13 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27311 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HARON, Razali [researchers_position] => IIUM Institute of Islamic Banking and Finance, International Islamic University Malaysia, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/GST-3.png [researchers_profile] => https://www.researchgate.net/profile/Razali-Haron-2 [researchers_second_profile] => https://orcid.org/0000-0003-0415-4093 ) [researchers_info_2] => Array ( [researchers_name_2] => AYOJIMI, Salami Mansurat [researchers_position_2] => Kulliyyah of Economics and Management Sciences, International Islamic University Malaysia, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/03/blowfly.png [researchers_profile_2] => https://www.researchgate.net/profile/Monsurat-Salami-2 [researchers_second_profile_2] => https://orcid.org/0000-0001-5314-8971 ) [original_article_reference] => [research_footprints] => consumer price index; producer price index; European Union; federal fund rate; future market; Schwarz information criterion; arbitrage pricing theory; nonfarm payroll employment; unemployment rate; Akaike information; criterion; GARCH; market volatility; Federal Open Market Committee [graphic_abstract] => [video] => [the_novelty] =>

This study analyzed the impact of fiscal reform initiatives on stock market volatility throughout the pre-, during, and post-announcement processes. By taking the scenario of Good and Service Tax (GST) implementation announced by the Malaysian government in 2014, the study proved that macroeconomic news announcement increases market volatility. This is especially true during and after the announcement of GST implementation; thus, contradicting past literature that scheduled macroeconomic news reduces market volatility. In other terms, it shows that the Malaysian government’s effort on educating its people through GST awareness programs was inefficient in preparing its people for the change. The attempt to understand the effect of GST on Malaysian stock index return volatility while controlling factors such as PPI, CPI, and UNEMPR, to the best of the researchers’ knowledge, is novel and contributes significantly to the existing literature on market volatility triggers.

[the_background] =>

As Malaysians can recall, the announcement of a 6 percent GST tax to be imposed for about 1200 selected items took the nation by surprise and triggered a stream of public debates, concerns, and uncertainties. A major shift in buying behaviors for items such as cars, furniture, and electrical appliances was noticed following the announcement period before the implementation. At the same time, the Malaysian government has been actively introducing GST awareness programs to educate the public on the tax implementation implications. Following such unsettling event, this research intends to understand how the market would react to the shocks and concerns revolving around this new tax reform. By understanding the expectation of the market, the government and policymakers could make better decisions when it comes to planning the nation’s tax reform.

[the_sdg_impact] =>

A recent article by EY (2020) quotes that “a comprehensive and well-thought-out tax reform can help a nation boost its economy which growing its tax revenue in the long run.” The OECD report on Tax and Economic Growth stated that the effects of tax levels and tax structures on agents’ economic behavior are likely to be reflected in overall living standards. Therefore, the findings of this study provide insights on public reactions towards tax reforms and their impact on market volatility which would benefit the government in future fiscal reform initiatives, as well as to understand the people’s pain point. In extension, this contributes to the efforts in promoting inclusive and sustainable economic growth as envisioned in UNSDG 8: Decent work and economic growth.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-06-2018-0027/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/GST-.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/gst_6253414_1619953744.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-06-2018-0027 [original_article_reference_fields] => Array ( [publication_title] => The impact of GST implementation on the Malaysian stock market index volatility: An empirical approach [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => December 2018 [subject] => Business; Economics; Finance ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/jcEhpehIt2o [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Article-7.mp4_snapshot_00.01_2021.08.04_09.47.39.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/gst-4.png ) ) [162] => WP_Post Object ( [ID] => 27286 [post_author] => 154 [post_date] => 2021-05-02 18:35:39 [post_date_gmt] => 2021-05-02 10:35:39 [post_content] => [post_title] => Direct Measure on Information Asymmetry and Its Influence on Firm Capital Structure Decisions [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => direct-measure-on-information-asymmetry-and-its-influence-on-firm-capital-structure-decisions [to_ping] => [pinged] => [post_modified] => 2021-09-26 17:44:03 [post_modified_gmt] => 2021-09-26 09:44:03 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27286 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WONGCHOTI, Udomsak [researchers_position] => School of Economics and Finance, Massey University, New Zealand [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/asymmetry.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => WU, Fei [researchers_position_2] => LLC Program Academic Director, Shanghai Advanced Institute of Finance, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/asymmetry-3.png [researchers_profile_2] => [researchers_second_profile_2] => https://orcid.org/0000-0003-2322-9302 ) [original_article_reference] => [research_footprints] => explanatory power; debt ratio; asymmetric information; pecking order; debt financing; transition period; order theory; state-owned enterprises; capital structure; liquidity ratio; information asymmetry [graphic_abstract] => [video] => [the_novelty] =>

This microstructure-based study provides firm evidence that there is a positive association between information asymmetry of firms and new debt issuances on the direct prediction of the pecking order theory in the Chinese stock market during the non-tradable shares (NTS) Reform period. The higher the misalignment between firm management knowledge and investor awareness, the higher the levels of debt usage. The variation in debt usage among Chinese firms during the NTS Reform period (2005-2007) also proves that financial markets do play a significant role on real economic activity. Thus, the findings agree to the traditional pecking order theory and signify that asymmetric information issue in the capital market should be taken into consideration by corporate managers.

[the_background] =>

In corporate finance, the pecking order theory reflects the effect of informational disadvantage on cost of financing. Following the NTS Reform in China between 2005 and 2007, the capital market has been increasingly subjected to information asymmetry problems. The impact of such scenario on a firm’s capital structure decisions is hardly known as there is lack of a direct measure on information asymmetry. Thus, this study employs microstructure research techniques to detect the degree of influence information asymmetry has on the new debt issuances in China, and its consistency with the traditional pecking order theory.

[the_sdg_impact] =>

The 8th United Nations’ Sustainable Development Goal, Decent Work and Economic Growth, aims to promote inclusive and sustainable economic growth, employment and decent work for all. The positive relation between information asymmetry and debt issuance as proved in this study during the NTS Reform period would benefit corporate managers and policymakers in making deciding fiscal reform initiatives. The new microstructure research techniques used could potentially be used for more capital market studies which traditionally lacked direct testing tools.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-04-2018-0006/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/asymmetry-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/asymmetry_6252981_1619951349.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-04-2018-0006 [original_article_reference_fields] => Array ( [publication_title] => Does information asymmetry lead to higher debt financing? Evidence from China during the NTS Reform period [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => May 2018 [subject] => Business; Economics; Finance ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/yNVg8t65754 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/06.mp4_snapshot_00.01_2021.07.14_11.57.50.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/asymmetry-2.png ) ) [163] => WP_Post Object ( [ID] => 27262 [post_author] => 154 [post_date] => 2021-05-02 13:50:32 [post_date_gmt] => 2021-05-02 05:50:32 [post_content] => [post_title] => Factors Influence CSR Transparency in Developing Countries [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => factors-influence-csr-transparency-in-developing-countries [to_ping] => [pinged] => [post_modified] => 2021-12-02 12:51:36 [post_modified_gmt] => 2021-12-02 04:51:36 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27262 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SALEHI, Mahdi [researchers_position] => Department of Economics and Administrative Sciences, Ferdowsi University of Mashhad, Iran [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Empirical-.png [researchers_profile] => https://www.researchgate.net/profile/Mahdi-Salehi-2 [researchers_second_profile] => https://orcid.org/0000-0003-2698-9817 ) [researchers_info_2] => Array ( [researchers_name_2] => TARIGHI, Hossein [researchers_position_2] => Department of Economics and Administrative Sciences, Attar Institute of Higher Education, Iran [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/05/Empirical-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Hossein-Tarighi [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => variance inflation factor; Tehran Stock Exchange; audit risk; financial leverage; corporate social responsibility [graphic_abstract] => [video] => [the_novelty] =>

This study reflects upon some key factors affecting corporate social responsibility disclosure (CSRD) practices of Iranian companies and the influence of varying levels of CSRD on audit risk. Among the key factors investigated based on the Tehran Stock Exchange (TSE) list are firm size, financial leverage, profitability, firm age, and industry nature. According to the findings, the nature of the industry, firm size, and age could significantly influence companies' level of transparency in disclosing their CSR efforts, while financial leverage and profitability are the least of concern in this regard. Furthermore, companies are found to face higher audit risk when they are more open about their CSR practices.

[the_background] =>

Growingly, businesses are required to fulfill their social responsibilities through numerous CSR efforts and be transparent about it. By providing evidence of social and environmental responsibility practices, investors and other stakeholders are aware of the country’s economic sanctions to allow them to make informed decisions. CSRD, specifically on environmental disclosure, in annual reports are common practice among developed countries. However, there is close to no information available in the context of the Iranian market. Literature proved that there are a number of factors influencing companies’ decision to be transparent in terms of CSRD; in fact, managers are even seen to use it as an opportunity to address financial strains. Therefore, this study intends to provide policymakers with valuable information to align their monitoring efforts with auditors and corporations to enforce social obedience.

[the_sdg_impact] =>

Corporate social responsibility (CSR) efforts are indicators of corporate contributions to society's well-being, mostly out of goodwill. It has also been used as an attraction for foreign investors. Other outcomes of a company investing in CSR practices are to create wealth, employment and innovation, and improve market competitiveness through branding and customer loyalty. Therefore, this study's findings prove beneficial to investors, auditors, corporates, and policymakers of developing countries to re-evaluate their CSR practices and transparency in reporting to promote inclusive and sustainable economic growth. (SDG 8 Decent work and economic growth)

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-06-2018-0028/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Empirical-4.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Empirical_6250175_1619934211.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-06-2018-0028 [original_article_reference_fields] => Array ( [publication_title] => Empirical study on the effective factors of social responsibility disclosure of Iranian companies [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => December 2018 [subject] => Economics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/W9YZ8V6v8aw [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/05/Article-5.mp4_snapshot_00.01_2021.08.04_09.45.25.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/05/Empirical-6.png ) ) [164] => WP_Post Object ( [ID] => 27180 [post_author] => 154 [post_date] => 2021-04-25 16:06:15 [post_date_gmt] => 2021-04-25 08:06:15 [post_content] => [post_title] => Factors Influencing Foreign Investment in Developing Countries [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => factors-influencing-foreign-investment-in-developing-countries [to_ping] => [pinged] => [post_modified] => 2021-12-02 12:42:45 [post_modified_gmt] => 2021-12-02 04:42:45 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27180 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ASIAMAH, Michael [researchers_position] => School of Economics, University of Cape Coast, Cape Coast, Ghana [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/04/FDI.png [researchers_profile] => https://www.researchgate.net/profile/Michael-Asiamah-2 [researchers_second_profile] => https://orcid.org/0000-0001-7364-4139 ) [researchers_info_2] => Array ( [researchers_name_2] => OFORI. Daniel [researchers_position_2] => Department of Marketing and Supply Chain Management, University of Cape Coast, Cape Coast, Ghana [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/04/FDI2.png [researchers_profile_2] => https://www.researchgate.net/profile/Daniel-Ofori [researchers_second_profile_2] => https://orcid.org/0000-0002-7546-6716 ) [original_article_reference] => [research_footprints] => Sub-Saharan Africa; exchange rate; ordinary least square; cointegration; economy; electricity production; economic growth; foreign direct investment; interest rate; determinants; gigawatt hours; akaike information criterion [graphic_abstract] => [video] => [the_novelty] =>

With regards to Ghana’s goal of becoming a higher-income earning country, this study explored the relationship between foreign direct investment (FDI) and macroeconomic variables. Based on the 1990-2015 data set analysis, it was found that GDP, electricity production, and telephone subscriptions positively impacted the FDI of the country for both short- and long-term growth, while inflation, interest rate, and exchange rate had the opposite effect. As a result, these findings led to the proposal of a number of policy recommendations for the government of Ghana to consider to improve its FDI inflows: 1-Need for exchange rate targeting strategy; 2-Ensure the maintenance of low inflationary rate; 3-Expand telephone subscriptions; 4-Expand electricity production through collaborative efforts; 5-Reduce interest rate by financial institutions; 6-Increase country’s per capita GDP.

[the_background] =>

In comparison to Eastern European and Asian markets, the African countries receive the least funds from bilateral and multilateral lending institutions. Moreover, debt services are viewed as a massive burden for African governments, thus, constraining the capacity to provide quality social services for the citizens. By looking into the determinants of FDI inflows, this study aims to provide the policymakers, investors, banking institutes, and even the public with functional strategies to boost the economy. In extension, this study also intends to be used as a reference to raise the living standards and provide improved social protection for the people of Ghana.

[the_sdg_impact] =>

The primary goal of the United Nations is to reduce poverty and accelerate human development in developing countries, which has been made quite clear through its 1st Sustainable Development Goal: No Poverty. To do so, significant capital investment is required, and FDI behaves as an essential medium for capital inflows for many developing countries. By understanding the determining factors of FDI inflows, appropriate and strategic measures can be taken to improve the economic status of the country, creating more job opportunities, and eventually reducing the poverty rate of its people.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-08-2018-0057/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/04/fdi3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/04/fdi_6107197_1619337132.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-08-2018-0057 [original_article_reference_fields] => Array ( [publication_title] => Analysis of the determinants of foreign direct investment in Ghana [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => January 2019 [subject] => Business; Economics; Finance ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/6WmM9j8FFA8 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/04/04.mp4_snapshot_00.01_2021.07.14_11.03.57.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/04/fdi6.png ) ) [165] => WP_Post Object ( [ID] => 27159 [post_author] => 154 [post_date] => 2021-04-25 15:21:39 [post_date_gmt] => 2021-04-25 07:21:39 [post_content] => [post_title] => Examining the Issue of High Current Account Deficit (CAD) of India from Various Perspectives [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => examining-the-issue-of-high-current-account-deficit-cad-of-india-from-various-perspectives [to_ping] => [pinged] => [post_modified] => 2021-12-02 10:24:58 [post_modified_gmt] => 2021-12-02 02:24:58 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27159 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => BEHERA, Harendra Kumar [researchers_position] => Department of Economics and Policy Research, Reserve Bank of India, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/04/hendra.png [researchers_profile] => https://www.researchgate.net/profile/Harendra-Behera [researchers_second_profile] => https://orcid.org/0000-0002-9605-9415 ) [researchers_info_2] => Array ( [researchers_name_2] => YADAV, Inder Sekhar [researchers_position_2] => Department of Humanities and Social Sciences, Indian Institute of Technology Kharagpur, India [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/04/cad5.png [researchers_profile_2] => https://www.researchgate.net/profile/Inder-Yadav-2 [researchers_second_profile_2] => https://orcid.org/0000-0003-1576-3329 ) [original_article_reference] => [research_footprints] => unit root; cointegration; terms of trade; likelihood ratio; current account deficit; twin deficit; Reserve Bank of India; capital flow; trade openness; consumer price index; fiscal deficit; current account balance [graphic_abstract] => [video] => [the_novelty] =>

The outcome of this study suggests that the widening of CAD is due to a fall in household financial savings and corporate investments. Also, it is found that a large part of India’s CAD has been financed by FDI and portfolio investments which are partly replaced by short-term volatile flows. The unit root and cointegration tests indicated a sustainable current account for India. Further, econometric analysis revealed that India’s current account is driven by the fiscal deficit, trade growth, inflation, real deposit rate, trade openness, relative income growth, and the age dependency factor.

[the_background] =>

The central goal of a country’s macroeconomic policy is to achieve a simultaneous balance between internal and external sectors. Maintaining internal balance requires keeping inflation low and stable, and potential output or unemployment rate at desired levels. It is also important that the current account balance (CAB) (especially CAD) be kept at a sustainable level to achieve the external balance. However, CAD is neither an explicit policy variable such as money supply or fiscal position, nor an ultimate policy target like output growth, inflation, or unemployment rate. But, CAD is often viewed by policymakers as a necessary “intermediate target” that reflects the stance of a country’s macroeconomic policies and doubles as a source of information about the behavior of economic agents. Also, with a rising working-age and skilled population, India should focus more on high-value product exports than low-value manufactured items. Furthermore, it is important to correct fiscal deficit on the structural side as it is one of the essential factors contributing to large CAD.

[the_sdg_impact] =>

India’s CAD has widened in the last few years mainly because of the rise in gold and oil imports and increased investment income payments in conjunction with fall in investment income receipts, despite a large comfort provided by the services sector and private remittances. Given the large demand in India, it isn't easy to control import growth. Thus, policymakers should focus on achieving phenomenal export growth to maintain a sustainable current account. With a rising working-age and skilled population, India could focus more on high-value product exports than low-value manufactured items. All in all, this study aligns well with the financial targets of UNSDG 17: Partnerships for the Goals, especially in terms of encouraging and promoting effective public, public-private, and civil society partnerships, building on the experience and resourcing strategies of partnerships

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-11-2018-0089/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/04/cad2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/04/cad_6107047_1619334635.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-11-2018-0089 [original_article_reference_fields] => Array ( [publication_title] => Explaining India’s current account deficit: a time series perspective [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => March 2019 [subject] => Business; Economics; Finance ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/ndndOFH40Bk [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/04/Article-3.mp4_snapshot_00.01_2021.08.04_09.42.46.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/04/CAD.png ) ) [166] => WP_Post Object ( [ID] => 27141 [post_author] => 154 [post_date] => 2021-04-25 14:50:10 [post_date_gmt] => 2021-04-25 06:50:10 [post_content] => [post_title] => Ecotourism: How to be Customer’s No. 1 Choice? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => ecotourism-how-to-be-customers-no-1-choice [to_ping] => [pinged] => [post_modified] => 2021-12-02 10:22:07 [post_modified_gmt] => 2021-12-02 02:22:07 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27141 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NGOC THUY, Vo Thi [researchers_position] => Faculty of Business Administration, University of Economics and Law, Vietnam National University Ho Chi Minh City, Vietnam [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/blowfly.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => PHUONG THAO, Hoang Doan [researchers_position_2] => Faculty of Business Administration, University of Economics and Law, Vietnam National University Ho Chi Minh City, Vietnam [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/03/blowfly.png [researchers_profile_2] => https://www.researchgate.net/scientific-contributions/Hoang-Doan-Phuong-Thao-2119431794 [researchers_second_profile_2] => https://orcid.org/0000-0001-8421-0440 ) [original_article_reference] => [research_footprints] => categorization; customer satisfaction; service quality; ecotourism; satisfaction; exploratory factor analysis; international tourism [graphic_abstract] => [video] => [the_novelty] =>

This study proposed a new model for the ecotourism service quality index by modifying the existing models to include price-quality inference and experiential attributes. The findings suggested four additional dimensions, namely price-quality, interaction with locals, interaction with other customers, and sense of relaxation, to be taken into consideration when measuring service quality. In addition, it was highlighted that the influence of these service quality attributes on customer satisfaction can be categorized into four groups: one-dimensional, must-be, attractive, and indifferent. Hence, this new model promises to provide a highly satisfactory ecotourism experience by encouraging eco-site management to design and deliver services by integrating the identified factors and attributes. With that said, the study also emphasized that a customer’s lack of satisfaction does not equate to dissatisfaction; instead, the services could be improved for a better experience. Although this study focused on Vietnamese tourists, the findings could be useful to understand the source of satisfaction for ecotourists across the world.

[the_background] =>

Ecotourism is considered as the opportunity to experience and appreciate nature, local customs, and culture. Broadly, it encompasses natural tourism, cultural tourism, soft tourism, discoverable tourism, adventurous tourism, and responsible tourism. In this context, the two most commonly used service quality indicators are SERVQUAL and ECOSERV. These indicators paid more attention to factors like physical facilities and equipment and local recreational activities, with little emphasis on gauging the motivation and experience of ecotourists. Therefore, this study aims to incorporate new dimensions of service quality and attributes to better measure customer satisfaction. Ultimately, the findings are to be used to develop a new comprehensive model for ecotourism service quality measurement.

[the_sdg_impact] =>

Ecotourism is a sub-component of sustainable tourism and is perceived as a potentially effective tool for sustainable development to be included in economic development and conservation strategies. Following the 2018 UN Intergovernmental Panel on Climate Change (IPCC) special report, a growing awareness of climate change has been observed, and people are becoming more environmentally conscious. A 2020 survey even showed that one in ten (69%) travelers worldwide believe that green travel is important. With that being the case, eco-site management should ensure a better customer experience to keep the ecotourism industry flourishing. Such efforts would include strengthening protection and safeguarding the world’s cultural and natural heritage through sustainable development planning, as proposed by UNSDG 11: Sustainable Cities and Communities.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-07-2018-0051/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/04/ecotourism.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/04/Hoang-Doan_6106775_1619332639.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-07-2018-0051 [original_article_reference_fields] => Array ( [publication_title] => Ecotourists’ satisfaction and dissatisfaction: asymmetric effects of service attributes [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => June 2019 [subject] => Business; Economics; Ecotourism ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/9y2tTIl5LC0 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/04/02.mp4_snapshot_00.01_2021.07.14_10.13.20.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/04/ecotourism4.png ) ) [167] => WP_Post Object ( [ID] => 27119 [post_author] => 154 [post_date] => 2021-04-25 13:59:46 [post_date_gmt] => 2021-04-25 05:59:46 [post_content] => [post_title] => Four Lenses of Cryptocurrencies: Money, Legal, Economic, and Sharia Law [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => four-lenses-of-cryptocurrencies-money-legal-economic-and-sharia-law [to_ping] => [pinged] => [post_modified] => 2022-06-14 12:51:44 [post_modified_gmt] => 2022-06-14 04:51:44 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27119 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YUNELINE, Mirza Hedismarlina [researchers_position] => Management Study Program, School of Business Ekuitas, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/04/cryptocurrency4.png [researchers_profile] => https://www.researchgate.net/profile/Mirza-Yuneline [researchers_second_profile] => http://orcid.org/0000-0003-1862-5431 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => cryptocurrency; money; journal article; monetary value; currency [graphic_abstract] => [video] => [the_novelty] =>

This study spearheads the analysis on the impacts of cryptocurrencies on money, legal perspective, economic perspective, and Sharia perspectives. From the perspective of money, the findings suggest that selected cryptocurrencies are readily accepted as payment and become an alternative in this current internet-fuelled global market. However, some countries have issued a ban on Bitcoin and other cryptocurrencies due to bypassing central bank authorities. From an economic perspective, this paper analyses whether cryptocurrencies will fulfill the characteristic of a successful currency. In general, Sharia scholars have two different opinions. The first group argues that cryptocurrency is prohibited by Islamic Law (haram). Another group believes that it is permissible in Islamic Law (halal). Furthermore, this study also considers the opportunities and risks of cryptocurrency that may happen.

[the_background] =>

As mentioned above, being invented by using cryptography techniques and using distributed ledger has made cryptocurrency a popular alternative as a medium of exchange due to its safety, transparency, and cost-effectiveness. But its main feature cannot be separated from the activities of users who use cryptocurrency for their illegal transactions. Since the cryptocurrency is bypassing the central authority, it is not admitted as a legal tender. The following are some opportunities and risks of cryptocurrency:

1. Opportunities:
- strengthening global financial efficiency by reducing transaction and costs by facilitating peer-to-peer exchange;
- in the long term, the technologies have the potential in deepening financial inclusion by offering secure and low-cost payment options; and
- the implications can affect financial market infrastructures for the secure, accurate, and fast settlement transaction process.

2. Risks:
- misused for illegal activities;
- risky for financial stability because it is not backed with any assets; and
- lack of consumer protection because there are no central authorities behind it.

[the_sdg_impact] =>

Cryptocurrency is a digital currency based on a peer-to-peer payment system managed by open-source software and characterized by lower transaction costs, greater security and scalability than fiat money, and no need for a central bank. This makes cryptocurrencies not only a truly independent archive of records, a virtual ledger, but also one of the safest and the most reliable data transportation systems available today. Despite criticisms about illegal uses and social consequences, it is attracting the interest of the scientific community. This work aims to define and evaluate the current trends of the literature concerned with the sustainability of cryptocurrency, considering the environmental impacts, social issues, and economic aspects. All in all, this study aligns well with UN Sustainable Development Goals 17: Partnerships for the Goals, especially in funding gap in fast and innovative ways by providing transparency and accountability without the need for costly intermediaries.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-12-2018-0107/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/04/cryptocurrency2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/04/Mirza-Hedismarlina_6106280_1619329556.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1108/JABES-12-2018-0107 [original_article_reference_fields] => Array ( [publication_title] => Analysis of cryptocurrency’s characteristics in four perspectives [journal_title] => Journal of Asian Business and Economic Studies [publisher] => Emerald Publishing [year] => August 2019 [subject] => Business; Cryptocurrency; Economics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/C0ZNAUI6_5I [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/04/Article-1.mp4_snapshot_00.01_2021.08.04_09.39.47.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/04/cryptocurrency5.png ) ) [168] => WP_Post Object ( [ID] => 27054 [post_author] => 154 [post_date] => 2021-04-21 12:22:02 [post_date_gmt] => 2021-04-21 04:22:02 [post_content] => [post_title] => Performance Improvement of Liquid-Based Detector via Dynamic Geometry Information Exchange [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => performance-improvement-of-liquid-based-detector-via-dynamic-geometry-information-exchange [to_ping] => [pinged] => [post_modified] => 2022-07-11 12:15:57 [post_modified_gmt] => 2022-07-11 04:15:57 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=27054 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YOU, Zhengyun [researchers_position] => School of Physics, Sun Yat-sen University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/04/Zhengyun-You.png [researchers_profile] => https://www.researchgate.net/profile/Zhengyun-You [researchers_second_profile] => https://orcid.org/0000-0001-8324-3291 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => large underground xenon; deep underground neutrino experiment; super kamiokande; geometry; dark matter; simulation; neutrino observatory; constructive solid geometry; neutrino experiment; computational fluid; dynamics; dynamic geometry; Geant4 [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/04/NST_Article-06_V1-0601_001.png [video] => [the_novelty] =>

In order to enhance the key performance of a liquid-based detector used in the studies of particle and nuclear physics, this study has proposed a development which considered the impact of a liquid flow and non-uniformity on the detector’s accuracy. The development was based on geometry description markup language (GDML) and a tessellated detector description to share the detector geometry information between computational fluid dynamics (CFD) simulation software and detector simulation software. The feasibility of this method was shown in a simulation with a non-uniform medium and with a deviation in the event of a vertex reconstruction. By applying it to analyze other dynamic geometry-related problems in particle and nuclear physics, its potential and performance could be further explored as well as optimized.

[the_background] =>

A large-scale liquid-based detector is an essential tool being utilized in particle and nuclear physics experiments, especially in neutrino experiments and dark matters studies. To fulfil the requirements of the studies, liquid-based detectors with larger size have been designed. As the size increases significantly, maintaining the uniformity in the liquid will be a challenge which directly affects the performance of the detector. Furthermore, the uniformity of the optical properties (e.g. refractive index) of the liquid also depends mainly on the liquid flow in the detector. To consider the implication of the liquid flow and non-uniformity on the performance of the detector, this study has proposed a development to exchange the detector geometry information between different software programs. The output of this study sets a milestone in the design of liquid-based detectors.

[the_sdg_impact] =>

The new development and improvement of liquid-based detectors has contributed to a series of experimental and theoretical studies to assess the astrophysical- and geo-neutrinos. Neutrinos are one of the most abundant particles in the universe. They have very little interaction with matter and that explains they are incredibly difficult to detect. This development is a major step towards the study of neutrinos and dark matter, an innovation that potentially spins-off many other industrial and infrastructure applications (UNSDG 9: Industries, Innovation & Infrastructure).

[article_url] => https://link.springer.com/article/10.1007/s41365-021-00852-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/04/liquid-detector.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/04/liquid_6024229_1618993251.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00852-8 [original_article_reference_fields] => Array ( [publication_title] => A method for sharing dynamic geometry information in studies on liquid-based detectors [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => February 2021 [subject] => Physics; Engineering; Nuclear ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/ODDYNJt3IzA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/04/06.mp4_snapshot_00.00_2021.06.11_11.15.13.jpg [figures] => ) ) [169] => WP_Post Object ( [ID] => 26564 [post_author] => 154 [post_date] => 2021-04-02 13:45:32 [post_date_gmt] => 2021-04-02 05:45:32 [post_content] => [post_title] => Molecular View of the Catfish Craniofacial Sensory Structure Development [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => molecular-view-of-the-catfish-craniofacial-sensory-structure-development [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:15:12 [post_modified_gmt] => 2021-09-13 08:15:12 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=26564 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MURAKAMI, Yasunori (村上安則) [researchers_position] => Graduate School of Science and Engineering, Ehime University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/04/荒川和晴2.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Yasunori-Murakami-38895708 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => evolution; phosphate-buffered saline; body surface; morphology; signaling molecules; catfish; danio rerio; developmental process; barbels; adaptive radiation; peripheral nerves; reverse transcription; silurus asotus; standard deviation; facial nerve; taste bud; dimethyl sulfoxide; ameiurus nebulosus; amur catfish; polymerase chain reaction [graphic_abstract] => [video] => [the_novelty] =>

This study provides insights on the development of unique craniofacial structures and taste buds of Amur catfish from a molecular perspective. By observing lab-grown catfish embryos, a number of signaling molecules were identified to influence the formation of catfish-specific morphology. The findings elaborate in exhaustive details on the roles of SHH and FGF8 as regulators for the development of craniofacial sensory structures in Amur catfish. Since these signaling molecules are common among all vertebrates, knowledge on the expression and regulation could be beneficial to understand the evolutionary novelty in catfish species as well as other fishes.

[the_background] =>

There are over 3730 living species of catfishes distributed across almost every saltwater and freshwater sources. Its unique morphologies include enlarged jaws with movable barbels and taste buds covering the entire body surface. These characteristics serve as a crucial evolutionary measure in their rapid diversification to survive in the freshwater ecosystem. With that said, little is known about the developmental processes and molecular mechanisms responsible of these characteristics. Therefore, this study uses comparative and experimental research models to comprehend the developmental processes between different species of catfish and identify the genes responsible for its unique morphology.

[the_sdg_impact] =>

Aquaculture or fish farming are considered to be a more sustainable approach to meet the global demand for seafood. Catfish farming has been recognized as one of the easiest and most flexible business due to the high resilience and prolific nature of this freshwater fish. By understanding the fundamentals of the catfish development morphology, researchers could work alongside decision-makers and aquaculture practitioners to implement science-based management plans to restore fish stokes in the shortest time feasible for maximum sustainable yield as determined by their biological characteristics. Essentially, such expansion of this study aligns well with the visions of UN SDG 14: Life Below Water, where scientific knowledge is leveraged to improve the sustainable management of marine resources.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0135-1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/04/catfish.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/04/catfish4_5620108_1617341642.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0135-1 [original_article_reference_fields] => Array ( [publication_title] => FGF- and SHH-based molecular signals regulate barbel and craniofacial development in catfish [journal_title] => Zoological Letters [publisher] => BMC [year] => June 2019 [subject] => Science and Engineering ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/g_jep7ZS-Z4 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/04/Molecular-view-of-the-catfish-craniofacial-sensory-structure-development.mp4_snapshot_00.01_2021.08.13_16.42.06.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/04/catfishga.png ) ) [170] => WP_Post Object ( [ID] => 26528 [post_author] => 154 [post_date] => 2021-04-02 12:17:37 [post_date_gmt] => 2021-04-02 04:17:37 [post_content] => [post_title] => 8 New Species Identified from R. coronifer Redescription [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => 8-new-species-identified-from-r-coronifer-redescription [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:16:13 [post_modified_gmt] => 2021-09-13 08:16:13 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=26528 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ARAKAWA, Kazuharu (荒川和晴) [researchers_position] => Institute for Advanced Biosciences, Keio University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/04/Richtersius-4.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Kazuharu-Arakawa-2114078077 [researchers_second_profile] => https://orcid.org/0000-0002-2893-4919 ) [researchers_info_2] => Array ( [researchers_name_2] => MICHALCZYK, Łukasz [researchers_position_2] => Institute of Zoology and Biomedical Research, Jagiellonian University, Poland [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/04/lukas.png [researchers_profile_2] => https://www.researchgate.net/profile/Lukasz-Michalczyk [researchers_second_profile_2] => https://orcid.org/0000-0002-2912-4870 ) [original_article_reference] => [research_footprints] => C. elegans; nominal species; richtersius coronifer; spitsbergen; bayesian information criterion; bayesian inference; transcriptome; scanning electron microscopy; biodiversity; hypsibius dujardini; taxonomy; species diversity [graphic_abstract] => [video] => [the_novelty] =>

The redescription of R. coronifer is a significant contribution in the tardigrade taxonomy, as it opens an array of hope for the exploration of species diversity. Recently, the species has become a popular model organism in physiological studies on cryptobiosis. Out of 13 analyzed populations, 8 were potentially identified as new species, thus, demonstrating that there is hidden species diversity within the genus Richtersius. The outdated and incomplete original description may now be replaced with detailed morphological and molecular data. To avoid future misidentifications and prevent taxonomic obstacles, it is strongly recommended that the new species in the genus be described by means of integrative taxonomy.

[the_background] =>

In the past, the limited availability of analytical tools along with the assumption that tardigrade species exhibit morphological variability led to underestimations of the species diversity. Many older species which were considered to have global distributions are now recognised as complexes of species comprising morphologically very similar taxa, possibly each with a limited geographic range. Out-dated descriptions and the lack of material for the type taxa are obstacles to species descriptions within a given group, such as the R. coronifer. The modern redescription of R. coronifer will allow for a correct identification of populations used as laboratory models.

[the_sdg_impact] =>

Global diversity is losing its thrill due to human activities. Taxonomy provides fundamental understanding about the components of biodiversity which is necessary for effective decision-making about conservation and sustainable use. According to the Convention on Biological Diversity, misidentifications of a taxonomy can lead to many harmful outcomes. Therefore, it demands for crucial attention. The sustainable development goals are the blueprint towards a sustainable future, and this article shows Goal 12: Responsible Consumption and Production, in terms of dealing and handling tools and data related to the taxonomical field.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-0154-y [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/04/Richtersius-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/04/Richtersius_5619348_1617336498.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-020-0154-y [original_article_reference_fields] => Array ( [publication_title] => A new redescription of Richtersius coronifer, supported by transcriptome, provides resources for describing concealed species diversity within the monotypic genus Richtersius (Eutardigrada) [journal_title] => Zoological Letters [publisher] => BMC [year] => February 2020 [subject] => Advanced Biosciences ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/L3pAup_aDR4 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/04/8-new-species-identified-from-R.-coronifer-redescription.mp4_snapshot_00.01_2021.08.13_16.48.17.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/04/ga34.png ) ) [171] => WP_Post Object ( [ID] => 26297 [post_author] => 154 [post_date] => 2021-03-17 14:58:11 [post_date_gmt] => 2021-03-17 06:58:11 [post_content] => [post_title] => Increasing the Efficiency of Overall Handover Performance of Video Transmissions [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => increasing-the-efficiency-of-overall-handover-performance-of-video-transmissions [to_ping] => [pinged] => [post_modified] => 2022-01-24 17:28:12 [post_modified_gmt] => 2022-01-24 09:28:12 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=26297 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YAP, Timothy [researchers_position] => Faculty of Computing and Informatics (FCI), Multimedia University, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/videosharing-Timothy-Tzen-Vun-Yap.png [researchers_profile] => https://www.researchgate.net/profile/Timothy-Tzen-Vun-Yap [researchers_second_profile] => https://orcid.org/0000-0003-1277-1710 ) [researchers_info_2] => Array ( [researchers_name_2] => HASSAN, Md Mahedi [researchers_position_2] => Faculty of Computing and Informatics, Multimedia University, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/03/mmu.png [researchers_profile_2] => https://www.researchgate.net/profile/Mahedi-Hassan-2 [researchers_second_profile_2] => https://orcid.org/0000-0003-1889-8923 ) [original_article_reference] => [research_footprints] => base station; wifi; quality of service; common intermediate format; wireless network; performance metrics; data; access point; proxy mobile IPv6; vertical handover [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/03/videosharing4.png [video] => [the_novelty] =>

The research article presents the handover performance metrics of video transmissions over a network-side known as Proxy Mobile IPv6. Data transmission undergoes horizontal and vertical handover while a user is on the move, for example, Wi-Fi → Wi-Fi and 3G or 4G → Wi-Fi network. Through network simulation software, the research compared the handover performance metrics of three different protocols by extracting information on handover latency, jitter, cumulative measured, and peak signal-noise ratio. The simulation data analysis notes that an optimal overall handover performance of video transmission requires a fast network connection prior to moving or relocating. The data and interpretation of this research would be useful for the enhancement of future telecommunication tools.

[the_background] =>

Have you ever noticed, as you switch from Wi-Fi network to mobile data or vice versa, the video you are streaming becomes distorted and pixelated for a few seconds before returning to the original quality? That is an example of handover performance. Among the major drawbacks experienced by users during video transmission are the prolonged latency or delay and quality of services in the flow of handover process caused by the network switching. The primary aim of this research is to provide handover data essential for the formulation, stimulation, and evaluation of mobility management protocols. Based on the performance metrics provided, the process of handover and quality of service could be improved, especially for mobile phones.

[the_sdg_impact] =>

The increased usage of data has created a high demand for data quality. The mobile and wireless communication industries are constantly working on providing innovative solutions to smoothen the data transmission and improve the user experience when switching networks on their portable devices. In this case, the data article analyzed a potential protocol for a more seamless user experience, contributing to the realization of Goal 9: Industry, Innovation and Infrastructure. By providing information essential to improve the quality of wireless network services, further exploration of these data could facilitate the development of transformative digital infrastructure, such as 5G systems.

[article_url] => https://www.sciencedirect.com/science/article/pii/S2352340919310911?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/videosharing.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/Timothy-Tzen-Vun-Yap_5270843_1615963632.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.dib.2019.104736 [original_article_reference_fields] => Array ( [publication_title] => Data of vertical and horizontal handover on video transmission in Proxy Mobile IPv6 [journal_title] => Data in Brief [publisher] => Elsevier [year] => December 2019 [subject] => Computing and Informatics ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [172] => WP_Post Object ( [ID] => 26276 [post_author] => 154 [post_date] => 2021-03-17 14:27:54 [post_date_gmt] => 2021-03-17 06:27:54 [post_content] => [post_title] => Wired and Wireless Convergence Significantly Reduces Cost of 5G Roll-out [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => wired-and-wireless-convergence-significantly-reduces-cost-of-5g-roll-out [to_ping] => [pinged] => [post_modified] => 2021-11-27 15:58:26 [post_modified_gmt] => 2021-11-27 07:58:26 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=26276 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YUSOFF, Zulfadzli [researchers_position] => Faculty of Engineering, Multimedia University, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/5g-network-zulfadzli-yusoff.png [researchers_profile] => https://www.researchgate.net/profile/Zulfadzli-Yusoff [researchers_second_profile] => https://orcid.org/0000-0003-0764-5007 ) [researchers_info_2] => Array ( [researchers_name_2] => DAHAWI, Taha Hussein [researchers_position_2] => Department of Engineering, Multimedia University, Malaysia [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/03/taha.png [researchers_profile_2] => https://www.researchgate.net/profile/Taha-Dahawi [researchers_second_profile_2] => https://orcid.org/0000-0002-4451-3647 ) [original_article_reference] => [research_footprints] => error vector magnitude; orthogonal frequency division multiplexing; band stop filter; capital expenditure; multiple-input multiple-output; digital signal processing; local oscillator; polarization division multiplexing; digital-to-analog conversion; passive optical network; fast Fourier transform; optical line terminal; optical network units; radio over fiber; optical amplifier; millimeter wave; cyclic prefix; bit error rate; remote radio heads; intermediate frequency; optical distribution network; access network; subcarrier multiplexing [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/03/G4_graphical-abstract-1-1.jpg [video] => [the_novelty] =>

This study combined wireless and fiber technologies to develop a simple new low-cost network architecture to support 5G network applications. The integration of radio over fiber (RoF) and passive optical network (PON) provided an affordable 5G network application, while the multiple-input multiple-output (MIMO) technique, when associated with RoF-PON integration, improved the resource-utilization of PON system. The single-sideband frequency translation (SSB-FT) convergence technique resulted in a high spectrally efficient approach, significantly reducing the complexity of the architecture. The reuse of a remote optical local oscillator (LO) to downconvert the millimeter-wave (MMW) at the receiver further reduced the network design cost, potentially saving substantial capital expenditure. Thus, it is evident that this novel network design adopted integration to overcome the limitations of existing network technology to prepare for future 5G network requirements.

[the_background] =>

Terms such as the Internet of Things (IoT) and 5G mobile networks are products of the rapid transformation of the communication system. Part of the expectations towards future 5G technology is improved capacity, low latency, user-friendly, and sync across multiple devices seamlessly. Designing a network that fulfills all demands using the conventional approach is costly and complicated. Therefore, this study adopted an innovative approach by integrating wireless and wired signal transmission over the RoF-PON network to develop a simplistic, cost-effective, and highly reliable solution.

[the_sdg_impact] =>

5G technology and smart networks are recognized as powerful tools for achieving the United Nations’ Sustainable Development Goals. Undeniably, this transformative development will shape the future of mobile networks and information and communication technology. To date, one of the major obstacles faced in the implementation of 5G mobile network is the need for high investment to construct the network. The low-cost and high-capacity next-generation mobile network proposed by this study provides means to support the upcoming development. Thus, contributing to the realization of UNSDG 9: Industry, Innovation and Infrastructure by promoting an upgrade to infrastructure and technological capabilities through innovation.

[article_url] => https://www.osapublishing.org/jocn/abstract.cfm?uri=jocn-13-3-41 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/5g-network.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/zulfadzli-yusoff_5270238_1615961960.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1364/JOCN.413596 [original_article_reference_fields] => Array ( [publication_title] => Low-cost MIMO-RoF-PON architecture for next-generation integrated wired and wireless access networks [journal_title] => Journal of Optical Communications and Networking [publisher] => OSA Publishing [year] => January 2021 [subject] => Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [173] => WP_Post Object ( [ID] => 26256 [post_author] => 154 [post_date] => 2021-03-17 13:58:37 [post_date_gmt] => 2021-03-17 05:58:37 [post_content] => [post_title] => Influence of Financial Development on ESG Performance [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => influence-of-financial-development-on-esg-performance [to_ping] => [pinged] => [post_modified] => 2021-10-26 13:36:39 [post_modified_gmt] => 2021-10-26 05:36:39 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=26256 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NG, Tuan Hock [researchers_position] => Faculty of Business, Multimedia University, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/esg-Tuan-Hock-Ng.png [researchers_profile] => https://www.researchgate.net/profile/Tuan-Hock-Ng [researchers_second_profile] => http://orcid.org/0000-0001-9578-1628 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => foreign direct investment; non-governmental organisations; gross domestic products; panel data; research and development; ordinary least squares; environment; key performance indicators; knowledge gap; asia development bank; climate change; international monetary fund; financial sector; variance inflation factor; financial development Index; environmental degradation; belt and road Initiative [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/03/MMU_3_GA_Sustainability-in-Asia-The-Roles-of-Financial-Development-in-Environmental-Social-and-Governance-ESG-Performance.jpg [video] => [the_novelty] =>

This study spearheads the investigation on the impacts of financial development on environment, social, and governance (ESG) performance in Asia. A comprehensive assessment was conducted on 42 Asian countries to determine the relationship between different financial system segments and national ESG performances. The finding of the study indicates that the development of financial institutions and financial markets is vital for nations to pursue ESG goals in Asia. From the policymaking point of view, the study suggests the outlining of a standard ESG governance framework in the marketplace as a requirement for countries to support ESG goals. Therefore, governments need to maintain adequate monitoring and governance systems to ensure the functioning and development of the financial system.

[the_background] =>

Environmental, social, and governance (ESG) serve as a set of standards used by companies and countries to screen for potential investment opportunities. The ESG frameworks have also been seen by companies and countries as means to achieving sustainable development. Based on past studies, the development of the finance system has the potential to mitigate environmental degradation by funding green initiatives, promote social welfare via strong economic growth, and stimulate firm corporate governance to protect investors’ interest. With that said, there is still lack of evidence which suggests the link between financial development and ESG performance in the Asian context. Apart from filling the knowledge gap mentioned, this study also aims to use a more reliable indicator of financial development compared to the conventional indexes such as stock market capitalization, bank credits, etc. The proposed financial development index would cover both the financial institutions and the financial markets.

[the_sdg_impact] =>

A large part of Asia is made up of developing and underdeveloped countries. The findings of this study will be useful to strengthen resource mobilization to improve the ESG performance. ESG based investment decisions are directed toward long-term value creation to explore market potential, fulfil societal demands, and implement policy action for a sustainable and inclusive economic growth and well-being. In that sense, financial development plays a prominent role in allocating capitals for sustainable investments, encouraging managerial monitoring to bridge information asymmetries, and facilitating ESG-related risks and opportunities identification and management. All in all, this study aligns well with the financial targets of UNSDG 17: Partnerships for the Goals, especially in terms of resource mobilization.

[article_url] => https://link.springer.com/article/10.1007/s11205-020-02288-w [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/esg.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/Tuan-Hock-Ng-2_5269899_1615960455.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s11205-020-02288-w [original_article_reference_fields] => Array ( [publication_title] => Sustainability in Asia: The Roles of Financial Development in Environmental, Social and Governance (ESG) Performance [journal_title] => Social Indicators Research [publisher] => Springer Nature [year] => February 2020 [subject] => Business ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [174] => WP_Post Object ( [ID] => 26233 [post_author] => 154 [post_date] => 2021-03-17 13:20:29 [post_date_gmt] => 2021-03-17 05:20:29 [post_content] => [post_title] => Self-optimization Handover Management for 5G Communication [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => self-optimization-handover-management-for-5g-communication [to_ping] => [pinged] => [post_modified] => 2021-10-26 13:14:39 [post_modified_gmt] => 2021-10-26 05:14:39 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=26233 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ROSLEE, Mardeni [researchers_position] => Faculty of Engineering, Multimedia University, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/5g-Mardeni-Roslee.png [researchers_profile] => https://www.researchgate.net/profile/R-Mardeni [researchers_second_profile] => https://orcid.org/0000-0001-8250-4031 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => base station; small cell; heterogeneous network; user equipment; handover; quality of service; key performance indicators; additive white gaussian noise; mobility management; network performance; self-organizing network; optimization algorithm; medium access control; mobile communication; self-optimization [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/03/access-gagraphic-2961186.jpg [video] => [the_novelty] =>

The fifth-generation wireless network, 5G, promises to refine cellular network technologies by improving the speed of data transfer, reduce network congestions, and ensure seamless transfer of calls from one cell to another. In an attempt to enhance network handover (HO) performance, this study proposed a novel distributed auto-tuning optimization (ATO) algorithm that automatically tunes handover control parameters (HCPs) on the basis of user speed and received signal. The simulation of the proposed algorithm showcased an improvement in the overall system performance by over 80% when compared with other existing algorithms. The improvement includes reduced number of frequent HOs and HO failure (HOF) ratio, lower call drop rate, and reduced HO delay and interruption time during user mobility. Thus, assuring a more efficient and effective mobility management in 4.5G and 5G heterogenous networks (Hetnets).

[the_background] =>

Hetnet is a network connecting mobile devices with different operating systems. Rapid digitalization and increased reliance on the internet have resulted in the proliferation of broadband services, crowding the network traffic with too many channels to navigate through. The need to frequently switch between network cells has led to signal distortions, causing major inconvenience for the users. In order to address such mobility-related network disruption, this study proposed an intelligent network handover algorithm for LTE-A and 5G Hetnets. The study aims to use the proposed algorithm to replace the traditional, manual channel switching mechanism to ensure better overall network performance of future wireless communication technology.

[the_sdg_impact] =>

The UN predicts that 68% of the world’s population will live in urban areas by 2050. Smart cities are entering a new phase of Smart City 2.0 by integrating AI as well as Internet of Things (IoT) technologies into services. This transformation requires efficient transition of data with lower delay when communication networks are of concern. The outcome of this study is capable of improving existing information and communication technology to be more efficient and affordable. This would contribute to the realization of UNSDG 9: Industry, Innovation and Infrastructure, where a significant increase in internet accessibility and connectivity could be achieved.

[article_url] => https://ieeexplore.ieee.org/document/8937526 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/5g.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/Mardeni-Roslee_5269480_1615958028-1.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1109/ACCESS.2019.2961186 [original_article_reference_fields] => Array ( [publication_title] => Auto Tuning Self-Optimization Algorithm for Mobility Management in LTE-A and 5G HetNets [journal_title] => IEEE Access [publisher] => IEEE Explore [year] => December 2019 [subject] => Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [175] => WP_Post Object ( [ID] => 26212 [post_author] => 154 [post_date] => 2021-03-17 12:34:53 [post_date_gmt] => 2021-03-17 04:34:53 [post_content] => [post_title] => Digital Learning Strategies: Transforming Tertiary Students into Lifelong Learners [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => digital-learning-strategies-transforming-tertiary-students-into-lifelong-learners [to_ping] => [pinged] => [post_modified] => 2022-01-24 17:14:01 [post_modified_gmt] => 2022-01-24 09:14:01 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=26212 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ANTHONYSAMY, Lilian [researchers_position] => Faculty of Management, Multimedia University, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/digital-learners-Lilian-Anthonysamy.png [researchers_profile] => https://www.researchgate.net/profile/Lilian-Anthonysamy [researchers_second_profile] => http://orcid.org/0000-0003-1241-326X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => education for Sustainable Development; lifelong learner; learning environment; digital native; higher education; digital learning; resource management; lifelong learning; human capital; SmartPLS; blended learning; digital literacy [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/03/image_2021_04_02T04_50_41_598Z.png [video] => [the_novelty] =>

Digital learning has become the norm, and students require a specific set of skills to cope with it. This study proves that having structured self-management learning strategies enhanced digital literacy competencies among higher education students when performing digital learning tasks. When turned into a habit, these students are closer to becoming better lifelong learners. Based on a comprehensive analysis, three domains of self-management learning strategies were identified to influence digital learning efficiency, that is, metacognitive knowledge, resource management, and motivational belief. Contrary to some of the past literature, this study showed no positive relationship between cognitive engagement and digital literacy. Such in-depth understanding of learning strategies and their impact on digital skill mastery can improve the digital learning experience of students and prepare them to face future uncertainties.

[the_background] =>

Are you optimistic or skeptical about digital learning? As the pandemic abruptly forced schools, colleges, and universities to close down, it accelerated the digital transformation of education, particularly higher education. This new paradigm makes it crucial for graduates to equip themselves with digital learning best practices to help repurpose their career in case of need and solve work-related problems remotely and effectively. Taking such needs into account, this study aims to examine self-management learning strategies pivotal to improving digital learning attitudes and practices of university students. With a self-driven attitude, especially when learning in a digital setting, students are more likely to adopt sustainable lifelong learning.

[the_sdg_impact] =>

The social repercussion of the COVID-19 pandemic, digital disruption, is visible in education and the global workforce. This study believes that higher education transformation is essential to address the challenges and uncertainties of the new paradigm. One way to strive is to equip graduates with the ability to deal with new technological opportunities. Likewise, the United Nations’ 4th Sustainable Development Goal, quality education, also emphasizes the need to provide the younger generation with relevant skills to secure employment and encourage entrepreneurship. Thus, the findings of this study would be useful for students and educators to structure learning habits and tasks in line with promoting skills of the future, digital literacy.

[article_url] => https://link.springer.com/article/10.1007%2Fs10639-020-10201-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/digital-learners2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/Lilian-Anthonysamy_5269007_1615955155.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s10639-020-10201-8 [original_article_reference_fields] => Array ( [publication_title] => Self-regulated learning strategies in higher education: Fostering digital literacy for sustainable lifelong learning [journal_title] => Education and Information Technologies [publisher] => Springer Nature [year] => May 2020 [subject] => Management; Education ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [176] => WP_Post Object ( [ID] => 26139 [post_author] => 154 [post_date] => 2021-03-13 14:40:13 [post_date_gmt] => 2021-03-13 06:40:13 [post_content] => [post_title] => An In-Depth Study on the Dental Plate of Rhinochimeridae [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => an-in-depth-study-on-the-dental-plate-of-rhinochimeridae [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:17:43 [post_modified_gmt] => 2021-09-13 08:17:43 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=26139 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => JOHANSON, Zerina [researchers_position] => Department of Earth Sciences, Natural History Museum London, United Kingdom [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/Rhinochimeridae-4.png [researchers_profile] => https://www.researchgate.net/profile/Zerina-Johanson [researchers_second_profile] => https://orcid.org/0000-0002-8444-6776 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => scanning electron microscopy; holocephali; transmitted light; holocephalan; dental plate; mineralogy; whitlockite [graphic_abstract] => [video] => [the_novelty] =>

To better understand the dental plates of Harriotta raleighana (Rhinochimeridae, a type of long-nosed fish), this study discovered that the dental plates are made entirely of dentine tissue (mostly trabecular dentine). It was found that the arrangement of the hypermineralized dentine within the dental plate enabled the dentition of Harriotta to function without teeth. Throughout the study, dried specimens of Harriotta were examined and characterized using optical microscope and X-ray micro-computed tomography (μCT). The non-replacing dentition is renewed by constant trabecular dentine growth, framing the initial ovoids and tritors within a shell of outer dentine. All hard tissues are continuously replaced deep to the functional oral surface, with unmineralized spaces pre-forming in the trabecular dentine prior to ovoid and tritor dentine deposition in them. In terms of mineralization, calcium density profiles and concentrations of magnesium, phosphorus, and calcium ions reveal extreme differences in the level and type of mineralization. Early mineralization in ovoids and tritors has very high levels of magnesium. This was followed by a sudden increase in mineralization to high total mineral content. On the other hand, there was a gradual change of mineral in trabecular dentine in which its level remained low

[the_background] =>

Holocephalans (a taxon of cartilaginous fish in the class Chondrichthyes) have ovoids and tritors as their primary dentition. An ovoid is a rounded protrusion of the dental plate. A tritor is a slightly raised and rounded elevation of the dental plate. Before this study was conducted, there was limited work published to discuss in detail: 1) how holocephalans develop and maintain functional dentitions without the teeth that characterize other chondrichthyans such as sharks, skates, and rays; 2) how is this constantly growing dentition structured (statodont, all elements retained within the dentition rather than shed and lost) and how are the tissues continuously replaced; 3) how different types of dentine in these plates, including hypermineralized dentine, are arranged, and how this is renewed aborally; and 4) how the anatomy of the functional surface is dependent on the developmental growth and arrangement of dentine. Thus, this study was conducted to fill up the literature gap. The technique adopted in this study can be applied to other fishes to further expand the literature, which might provide new perspectives and research directions relevant to the organisms.

[the_sdg_impact] =>

The UN highlights that over three billion people depend on marine and coastal biodiversity for their livelihoods. This implies that the marine life forms playa crucial role in keeping the ecosystems balanced for the sustainability of the earth and humans. Hence, the knowledge imparted from this research is vital to help humans know more about marine life forms. Since the UN aims to increase scientific knowledge, develop research capacity, and transfer marine technology, this study is a step forward in achieving SDG 14: Life Below Water.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0125-3 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/Rhinochimeridae-2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/Zerina-Johanson_5194199_1615617256.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0125-3 [original_article_reference_fields] => Array ( [publication_title] => Growth and mineralogy in dental plates of the holocephalan Harriotta raleighana (Chondrichthyes): novel dentine and conserved patterning combine to create a unique chondrichthyan dentition [journal_title] => Zoological Letters [publisher] => BMC [year] => March 2019 [subject] => Zoology; Earth Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/FEMU9yV7XwI [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-16.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/03/Rhinochimeridae-5.png ) ) [177] => WP_Post Object ( [ID] => 25896 [post_author] => 154 [post_date] => 2021-03-11 13:39:51 [post_date_gmt] => 2021-03-11 05:39:51 [post_content] => [post_title] => Visualizing the Scent-related Organs of a Blowfly [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => visualizing-the-scent-related-organs-of-a-blowfly [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:18:45 [post_modified_gmt] => 2021-09-13 08:18:45 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=25896 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MAEDA, Toru (前田徹) [researchers_position] => Department of Biology, Graduate School of Science, Kobe University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/blowfly.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Antenna; olfactory receptor; phormia regina; olfactory receptor neurons; food preference; proboscis extension reflex; olfactory bulb; subesophageal ganglion; arabidopsis thaliana; blowfly; standard deviation [graphic_abstract] => [video] => [the_novelty] =>

Intrigued by the feeding behavior of insects, this study concludes that a blowfly has distinct compartments in the olfactory system that react to different scents. Such observation was only possible due to the novel glomerular map of Phormia regina (blowfly) constructed in this study through a histochemical method using an anti-pERK antibody. As a result, the glomeruli activated in response to odors and the appetite-triggers were identified. The study on the brain activity of blowfly showed that glomeruli DA13 responds to D-limonene (nonappetitive odor) via antennae while glomeruli MxB1 responds to 1-octen-3-ol (appetitive odor) via maxillary palp. Since the experimental design of this study has been useful in determining the odor information transmission mechanism of blowflies, it could also be used to further explore the factors and appetite patterns of other insects.

[the_background] =>

Phormia regina, commonly known as blowflies, feed on nectar and serve as excellent pollinators. Scientists have always been in awe of the ability of this species as well as other insects in selecting nutritious substances to consume while successfully avoiding toxic substances. Extensive research has been carried out on insect feeding patterns based on the gustatory system, a taste-driven sensory system. However, very little information connects the sense of smell to the appetite of blowflies. As an extension of the previous study, the author of this study aims to understand and connect the olfactory system to the feeding motivation of P. regina species. Through this study, the author also seeks to link the stimuli generated through the sense of smell with the gustatory response and identify the parts in the brain responsible for such response.

[the_sdg_impact] =>

Insects can serve as either pests or pollinators, but the large majority treats them as pests, especially when it comes to agriculture and farming. A catastrophe like a locust attack is a nightmare for many farmers, and so is selling insect-infested or aesthetically unpleasing produce, which has led to immense usage of pesticides and insecticides. The Food and Agriculture Organization has deliberately come up with a list to guide the users on the types of substances to protect the interest of the producers and the consumers. As mentioned in the United Nations 2nd Sustainable Development Goal, agricultural productivity must be protected and enhanced if zero hunger is to be achieved. Thus, understanding the insects’ feeding behavior and its mechanism would allow agriculture to flourish through effective insect repellent measures.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-00167-3 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/blowfly2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/Toru-Maeda_5151525_1615440303.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-020-00167-3 [original_article_reference_fields] => Array ( [publication_title] => Visualization of antennal lobe glomeruli activated by nonappetitive D-limonene and appetitive 1-octen-3-ol odors via two types of olfactory organs in the blowfly Phormia regina [journal_title] => Zoological Letters [publisher] => BMC [year] => November 2020 [subject] => Zoology; Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/x0j-AEJjarc [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-18.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/03/blowfly5.png ) ) [178] => WP_Post Object ( [ID] => 25875 [post_author] => 154 [post_date] => 2021-03-11 12:50:29 [post_date_gmt] => 2021-03-11 04:50:29 [post_content] => [post_title] => Typical Applications of X-ray Imaging for Different Fields of Study [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => typical-applications-of-x-ray-imaging-for-different-fields-of-study [to_ping] => [pinged] => [post_modified] => 2022-05-30 10:15:06 [post_modified_gmt] => 2022-05-30 02:15:06 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=25875 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => XIE, Honglan [researchers_position] => Shanghai Synchrotron Radiation Facility (SSRF), Shanghai Advanced Research Institute, Chinese Academy of Sciences, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/xray-imaging-author.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Honglan-Xie-2039142626 [researchers_second_profile] => http://orcid.org/0000-0003-0448-042X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => X-ray imaging; rare earth elements; spatial resolution; pair distribution function; numerical aperture; X-ray diffraction; tomography; 3DXRD; ordered subset expectation maximization; tomogram; complementary metal-oxide semiconductor [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/03/微信图片_20201028132216-1-scaled.jpg [video] => [the_novelty] =>

This study reports the latest developments of X-ray imaging methodology and new applications of the X-ray imaging and biomedical application beamline (BL13W1) in the past 5 years in the Shanghai Synchrotron Radiation Facility (SSRF). By equipping it with several sets of X-ray imaging detectors of different pixel sizes (0.19 – 24 m), the beamline (photon energy range of 8–72.5 keV) can realize X-ray micro-computed tomography (X-ray micro-CT) and X-ray in-line phase-contrast imaging. Based on these two basic methods, several x-ray imaging methods and image processing techniques were developed. Firstly, in vivo dynamic micro-CT experiments with living insects were successfully conducted in 0.5 s (sampling rate of 2 Hz, 2 tomograms/s) with a monochromatic beam and 40 ms (sampling rate of 25 Hz, 25 tomograms/s) with a white beam. Next, move contrast X-ray imaging (MCXI) was developed whereby the blood flow and moving tissues in raw images became distinguishable. Furthermore, the attempt to use X-ray speckle-tracking imaging with twice exposures to eliminate the edge enhancement effect was successfully developed. A high-precision quantification method via X-ray micro-CT to measure complex three-dimensional (3D) blood vessels was also developed. Besides, there was the development of an X-ray nano-CT with 100 nm spatial resolution too. By combining the X-ray micro-CT imaging method with other contrast mechanisms, three-dimensional X-ray diffraction (3DXRD) microscopy, small-angle X-ray scattering CT (SAXS-CT), and X-ray fluorescence CT (XFCT) were developed. These x-ray imaging methods and image processing techniques have been proven to bring the studies of material science, biomedicine, paleontology, physics, chemistry, and environmental science to a whole new level. With continuous research and development, it is clear that more experimental methods and techniques will be developed and provided to users to achieve more high-level applications.

[the_background] =>

With rapid technological advancement, there is a demand for research and development sectors to keep expanding and evolving. As a result, researchers are constantly setting up facilities, developing new research methodologies, and exploring new applications of existing equipment. X-ray was discovered more than a century ago. With an in-depth understanding of its properties, new applications could be derived by including additional features or integrating different tools. This study has reported that, within five years, multiples X-ray imaging methodologies and applications have been newly developed at the SSRF. Up to this point, the development has managed to benefit research in various fields, including material science, biomedicine, paleontology, physics, chemistry, and environmental science. Thus, more advanced studies can be conducted to enhance the technology with further improvement and innovation in developing X-ray imaging methods and techniques.

[the_sdg_impact] =>

Innovation and technological progress are key to finding lasting solutions to both economic and environmental challenges. Hence, scientific research and development play a crucial role in advancing technology and developing new methods to benefit our everyday routines. The X-ray imaging methodologies and techniques reported by this study have proven their respective potential in various fields of study. Since one of the United Nations’ main interests is to enhance scientific research, this study sets the path to realizing the objectives of UNSDG 9: Industries, Innovation & Infrastructure.

[article_url] => https://link.springer.com/article/10.1007%2Fs41365-020-00805-7 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/xray3.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/Honglan-Xie_5150995_1615437832.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-020-00805-7 [original_article_reference_fields] => Array ( [publication_title] => Methodology development and application of X-ray imaging beamline at SSRF [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => October 2020 [subject] => engineering; nuclear physics; nuclear technology; applied physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/yof78fKu-ck [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/Typical-Applications-of-X-ray-Imaging-for-Different-Fields-of-Study.mp4_snapshot_00.01_2021.06.11_11.26.02.jpg [figures] => ) ) [179] => WP_Post Object ( [ID] => 25851 [post_author] => 154 [post_date] => 2021-03-11 12:07:12 [post_date_gmt] => 2021-03-11 04:07:12 [post_content] => [post_title] => Compact Spectrometer for Heavy Ion Experiment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => compact-spectrometer-for-heavy-ion-experiment [to_ping] => [pinged] => [post_modified] => 2022-05-30 10:12:21 [post_modified_gmt] => 2022-05-30 02:12:21 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=25851 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WANG, Yijie (王轶杰) [researchers_position] => Department of Physics, Tsinghua University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/isospin-author-1.png [researchers_profile] => https://www.researchgate.net/profile/Yijie-Wang-19 [researchers_second_profile] => http://orcid.org/0000-0003-2692-8985 ) [researchers_info_2] => Array ( [researchers_name_2] => XIAO, Zhigang (肖志刚) [researchers_position_2] => Department of Physics, Tsinghua University, China [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/03/isospin-author-2.png [researchers_profile_2] => https://www.researchgate.net/profile/Zhi-Gang-Xiao [researchers_second_profile_2] => http://orcid.org/0000-0001-9534-5981 ) [original_article_reference] => [research_footprints] => silicon strip detector; telescope; HBT correlation function; nuclear equation of state [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/03/NST_Article-04_V0-0603_001.png [video] => [the_novelty] =>

As an attempt to facilitate the expansion of the field of nuclear and particle physics, this study constructed a Compact Spectrometer for Heavy Ion Experiment (CSHINE). The CSHINE consists of silicon strip detector (SSD) telescopes and large-area parallel plate avalanche counters (PPAC), which measure the light charged particles and fission fragments, respectively. When CSHINE was mounted and operated in the 30 MeV/u 40Ar + 197Au reaction, hydrogen and helium isotopes can be identified by analyzing the data obtained from the SSD telescopes. Moreover, the Hanbury Brown−Twiss (HBT) correlation functions of light-charged particles could be constructed from the data retrieved. These results eventually contributed to the measurement of isospin chronology. By utilizing CSHINE, more quantitative studies on the reaction dynamics and thermodynamics of nuclear matter produced in heavy ion collisions can be carried in the future.

[the_background] =>

An isospin is a quantum number to differentiate to neutron and proton. In nuclear physics, isospin dynamics are very important for understanding the effect of nuclear symmetry energy in heavy ion collisions. Hence, it is necessary to investigate the emission time of light-charged particles with different N/Z values (neutron-proton ratio) from the reactions. While the measurement reveals the isospin chronology, it also requires high-resolution determination of both the position and energy to reconstruct the HBT correlation function, which must be done before the isospin-dependent emission time constant can be derived. In order to achieve that, position-sensitive detectors with high granularity, high energy resolution and particle identification, for example, SSDs, are needed. Using the SSD telescopes in CSHINE, the correlation functions of different particle pairs can be measured to extract the emission time constant and emission hierarchy of the species. Based on the output so far, CSHINE showed high potential in facilitating experimental studies of the collision dynamics and nuclear equation of state in heavy ion reactions at Fermi energies.

[the_sdg_impact] =>

It is agreeable that both economic and environmental challenges can be overcome with progressive innovation and technologies. To ensure such progression is possible, equipment and tools must be developed and upgraded regularly to support scientific research efficiently. The design, construction, and applications of the CSHINE reported by this study have shown its importance in studying nuclear and particle physics. Thus, this study contributes to the materialization of UNSDG 9: Industries, Innovation & Infrastructure, in which one of the goal’s main targets is to enhance scientific research.

[article_url] => https://link.springer.com/article/10.1007/s41365-020-00842-2 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/isospin.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/Yijie-Wang_5150397_1615433941.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-020-00842-2 [original_article_reference_fields] => Array ( [publication_title] => CSHINE for studies of HBT correlation in heavy ion reactions [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => January 2021 [subject] => engineering; nuclear physics; nuclear technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/sz-FrJ-xtPA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/Compact-Spectrometer-for-Heavy-Ion-Experiment.mp4_snapshot_00.01_2021.06.11_11.29.03.jpg [figures] => ) ) [180] => WP_Post Object ( [ID] => 25827 [post_author] => 154 [post_date] => 2021-03-11 10:47:02 [post_date_gmt] => 2021-03-11 02:47:02 [post_content] => [post_title] => Revolutionizing the Field of Nuclear Energy with Newly Developed White Neutron Source [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => revolutionizing-the-field-of-nuclear-energy-with-newly-developed-white-neutron-source [to_ping] => [pinged] => [post_modified] => 2022-05-30 10:09:26 [post_modified_gmt] => 2022-05-30 02:09:26 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=25827 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TANG, Jingyu [researchers_position] => Institute of High Energy Physics, Chinese Academy of Sciences, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/03/nuclear-author.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Jingyu-Tang-2163431354 [researchers_second_profile] => http://orcid.org/0000-0002-5694-3783 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => spallation neutron source; energy spectrum; proton beam; data acquisition system; China Institute of Atomic Energy; China Spallation Neutron Source [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/03/NST_Article-03_V0-0601_001.png [video] => [the_novelty] =>

As part of an effort to come up with world-class neutron sources, this research has successfully built a white neutron beam facility known as the Back-n at China Spallation Neutron Source (CSNS). A consortium of five institutions was formed to support the design and construction of the beamline and experimental setups. The Back-n neutron beam has a high intensity of approximately 2 × 107 n/cm2/s at 55 m away from its target with a wide energy spectrum spanning from 0.5 eV to 200 MeV. Along with good time resolution related to the time-of-flight measurements, the Back-n neutron beam serves as a useful tool in nuclear data measurements, irradiation tests, detectors calibration, as well as neutron imaging and element analysis.

[the_background] =>

In China, nuclear energy is a crucial component in the development of future energy resources. Therefore, studies on advanced nuclear energy technologies have been receiving attention and firm support. There are high demands for an enhanced nuclear database in which nuclear data measurements with neutrons are fundamental. This project, which focuses on designing and constructing a state-of-the-art white neutron beam facility at CSNS, mainly intends to contribute to the advancement of nuclear energy technologies. Since commissioning, this facility has been proven to deliver a high-reliability performance and is able to conduct high-precision experiments. By mastering advanced experimental methods and exploring new techniques, the Chinese domestic chances of growing nuclear energy technologies within a shorter time frame increase immensely.

[the_sdg_impact] =>

According to the United Nations, energy is the dominant contributor to climate change, accounting for around 60 percent of total global greenhouse gas emissions. Thus, to overcome this, there is a need to develop an energy source that yields higher power efficiency with minimal waste. The groundbreaking output of this research will be facilitating a significant number of studies related to nuclear energy. In line with the UN’s vision, which is to double the global rate of improvement in energy efficiency by 2030, the outcome of this study has the potential to bring China a step closer to realizing the 7th Sustainable Development Goal – affordable and clean energy.

[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00846-6 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/03/nuclear2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/03/Jingyu-Tang_5149661_1615429062.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s41365-021-00846-6 [original_article_reference_fields] => Array ( [publication_title] => Back-n white neutron source at CSNS and its applications [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => January 2021 [subject] => engineering; nuclear physics; nuclear technology; Applied Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Fe3SmGeiecw [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/02.mp4_snapshot_00.01_2021.06.11_11.02.25.jpg [figures] => ) ) [181] => WP_Post Object ( [ID] => 21654 [post_author] => 154 [post_date] => 2021-02-23 19:27:42 [post_date_gmt] => 2021-02-23 11:27:42 [post_content] => [post_title] => New Species of Tardigrade Identified and Redescribed [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => new-species-of-tardigrade-identified-and-redescribed [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:20:22 [post_modified_gmt] => 2021-09-13 08:20:22 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21654 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CESARI, Michele [researchers_position] => Department of Life Sciences, University of Modena and Reggio Emilia, Italy [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/02/Michele-Cesari.png [researchers_profile] => https://www.researchgate.net/profile/Michele-Cesari [researchers_second_profile] => https://orcid.org/0000-0001-8857-3791 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => phase contrast; karyotype; bayesian inference; cox1; 18S rRNA; light microscopy; differential interference contrast; reproductive biology; tardigrada; amphimixis; scanning electron microscopy; genetic distance; cryptic species; confocal laser scanning microscopy; parthenogenesis; principal component analysis [graphic_abstract] => [video] => [the_novelty] =>

In order to clarify the relationships of various populations of Paramacrobiotus richtersi (a species of tardigrade), this study has identified four new tardigrade species (i.e., Paramacrobiotus arduus sp. n., Paramacrobiotus celsus sp. n., Paramacrobiotus depressus sp. n., and Paramacrobiotus spatialis sp. n.) and two Unconfirmed Candidate Species (UCS) within the P. richtersi complex. On top of that, it has also redescribed two species (i.e., Paramacrobiotus richtersi and Paramacrobiotus fairbanksi). P. fairbanksi (asexual) displayed a wider distribution (found in Italy, Spain, Poland and Alaska) compared to P. richtersi (sexual) due to their different method of reproduction, which affects the dispersal potential. Samples in the type locality in Ireland and in several Italian localities containing animals morphologically similar to P. richtersi were collected. These specimens were investigated with an integrative approach, i.e., studying morphology, karyology, reproductive biology, and DNA sequences. A similar technique can be applied to clarify the diversity of other species to establish a more in-depth understanding of various microorganisms.

[the_background] =>

Paramacrobiotus richtersi was reported to consist of populations with different chromosome numbers and reproductive modes. Hence, an updated and precise description of P. richtersi is needed to understand the taxonomy of the richtersi group and to better define the genus Paramacrobiotus. Therefore, this study took the initiative to investigate and clarify the relationships among different populations by adopting an integrative approach that involved studies of the samples from multiple aspects. This combined approach has been proven to be useful for detecting an unexpectedly high species diversity characterized by a complex of very similar species like P. richtersi. By applying this approach, scientists stand a higher chance of identifying different species under a complex of other microorganisms.

[the_sdg_impact] =>

UN emphasizes that innovation and technological progress are key to finding lasting solutions to both economic and environmental challenges. This implies that scientific research and development are crucial to catching up with innovation and technology. The research methodology adopted by this study has shown great potential in taxonomy study. Since one of the UN’s main interests is to enhance scientific research, this study sets the path to realizing the objectives of UNSDG 9: Industries, Innovation & Infrastructure.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-018-0113-z [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/02/Tardigrade.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/02/Michele-Cesari_4817258_1614079230.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-018-0113-z [original_article_reference_fields] => Array ( [publication_title] => High diversity in species, reproductive modes and distribution within the Paramacrobiotus richtersi complex (Eutardigrada, Macrobiotidae) [journal_title] => Zoological Letters [publisher] => BMC [year] => January 2019 [subject] => Life Sciences; Zoology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/EKqQrnisFNY [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-14.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/02/tardigrade-GA.png ) ) [182] => WP_Post Object ( [ID] => 21643 [post_author] => 154 [post_date] => 2021-02-23 12:13:00 [post_date_gmt] => 2021-02-23 04:13:00 [post_content] => [post_title] => Understanding the Biological Clock of Crickets [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => understanding-the-biological-clock-of-crickets [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:21:48 [post_modified_gmt] => 2021-09-13 08:21:48 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21643 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-020-00166-4 [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/02/cricket2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/02/Kenji-Tomioka_4810557_1614053187.mp3 [the_sdg_impact] =>

An in-depth understanding of the circadian clock of any animal or insect species would provide great insights into how these organisms function in terms of feeding or mating behavior, active or inactive phases, etc. By identifying biological markers or genes involved in controlling such functions, a fair comparison among different species could be made. With that, studies like this would aid in the planning and development process to not interfere with the daily activity of the insects crucial to an ecological and economic activity like pollination. Conversely, such knowledge could also be used to control or eradicate invasive alien species on land and water ecosystems. Therefore, this study could undoubtedly contribute to realizing the United Nations’ 15th Sustainable Development Goal (SDG): Life on land.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-00166-4 [the_background] =>

In general, the daily behavioral or physiological rhythms of insects are very much dependent on the circadian clock. Several clock genes, such as period (per), timeless (tim), Clock (Clk), and cycle (cyc), have been identified to play essential parts in regulating the circadian rhythms of insects. Extensive studies on the fruit fly (Drosophila) have proven the role of cwo in regulating the expression of the other clock genes. However, little is known of its influence on other insects. Therefore, this study aims to determine the role of cwo in the circadian clock of crickets and enrich the literature on the physiology of insects.

[research_footprints] => double-stranded RNA; danio rerio; optic lobe; e box; Cricket; gryllus bimaculatus; rna interference; circadian clock; clock gene; clockwork orange [graphic_abstract] => [video] => [the_novelty] =>

This study on the biological clock of the cricket Gryllus bimaculatus is the first to prove the influence of clockwork orange (cwo) gene in insect circadian rhythms other than that of fruit flies. A comprehensive analysis of the RNA-sequencing data revealed that the cwo of crickets is a clock gene of the bHLH-ORANGE family rhythmically expressed in the part of the brain that is related to the vision (optic lobes). Such finding agrees with the previously established literature on the biological clock of insects being light-sensitive and controlled by the expression of period (per) and timeless (tim) genes. It was also evident that the cwo rhythmic expression peaks specifically in the middle of the night under a light/dark (LD) cycle. Among the methods used to observe the influence of cwo on the circadian rhythm of crickets was the gene-knockdown approach via RNA interference (RNAi). As a whole, the findings of this study are crucial to understanding the active and inactive phases of insects and the biological markers influencing such behaviors.

[researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [researchers_info] => Array ( [researchers_name] => TOMIOKA, Kenji (富岡憲治) [researchers_position] => Graduate School of Natural Science and Technology, Okayama University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/02/kenji.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Kenji-Tomioka-38743942 [researchers_second_profile] => http://orcid.org/0000-0001-7951-8950 ) [original_article_reference_fields] => Array ( [publication_title] => The role of clockwork orange in the circadian clock of the cricket Gryllus bimaculatus [journal_title] => Zoological Letters [publisher] => BMC [year] => November 2020 [subject] => Zoology; Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Oe_pMOaeFps [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/02/Understanding-the-Biological-Clock-of-Crickets.mp4_snapshot_00.01_2021.05.24_10.11.01.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/02/criket-ga.png ) ) [183] => WP_Post Object ( [ID] => 21600 [post_author] => 154 [post_date] => 2021-02-18 12:16:41 [post_date_gmt] => 2021-02-18 04:16:41 [post_content] => [post_title] => What Makes Flatworms Hungry? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => what-makes-flatworms-hungry [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:22:49 [post_modified_gmt] => 2021-09-13 08:22:49 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21600 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0147-x [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [the_sdg_impact] =>

Studies on the environmental factors influencing animal behavior are crucial to maintain and improve ecological sustainability. The knowledge generated from this particular study could potentially influence the regulations on nutrient pollution or wastewater discharge into water sources to maintain the integrity of the aquatic ecosystem. Hence, contributing to the realization of UN SDG 14: Life below water by providing scientific evidence highlighting the adverse environmental impacts. On the contrary, the evidence on planarian feeding and reproduction behavior would serve as a guideline to optimize research methodologies when studying its regenerative ability, by extension, contributing to UN SDG 9: Industry, innovation and infrastructure, mainly on scientific research development.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0147-x [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/02/flatworms.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/02/Takeshi-Inoue_4699241_1613621397.mp3 [the_background] =>

The free-living flatworm (planarian Dugesia japonica) are commonly found in clear freshwaters, such as rivers and lakes. Its unique physiology makes it quite susceptible to toxins and pollutants in the aquatic environment; thus, making it a prime choice for the study of aquatic ecology and toxicology. Besides, the regenerative ability of these planarians makes them favorable laboratory specimens. Hence, past literature has extensively explored the ionic compositions of culture mediums suitable for planarian growth. However, how the ion concentration of the aquatic environment inhabited by the planarian affects its neural regulation remained unclear. Therefore, this study intends to explore the concentration-dependency of planarians in the natural aquatic environment. As a result, the findings would be beneficial to the feeding and breeding behavior of this species and its impact on the environment.

[research_footprints] => population size; aquatic environment; Dugesia japonica; water source; feeding behavior; natural source; body surface; reproduction rate; planarian; environmental changes; quantitative behavioristics; environment-responsive behavior; responsive sensitivity [graphic_abstract] => [video] => [the_novelty] =>

This study on free-living flatworm (Dugesia japonica) provided evidence that the concentration of ions in the environmental water affects its feeding behavior. It is identified that, to a certain extent, this phenomenon also influences its breeding pattern and population size. When compared between laboratory breeding waters and other natural sources, the findings show that calcium ion concentration significantly affects the free-living flatworms’ sensitivity of responsiveness to food. In this study, it is found that calcium ions in the environmental water activate the chemosensory neurons distributed in the body surface of the organism, not the brain neurons. These observations could be closely tied to the historical origin of the species where it once inhabited a calcium-ion rich environment. Noticeably, an improved food intake stimulated by the increase in calcium ion concentration also increases the reproduction rate of these flatworms. Due to its predatory nature, such increases could lead to devastating ecological impacts if the ionic composition of water sources is not kept in check.

[researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [researchers_info] => Array ( [researchers_name] => INOUE, Takeshi (井上武) [researchers_position] => Division of Adaptation Physiology, Faculty of Medicine, Tottori University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/02/Takeshi-Inoue.png [researchers_profile] => https://www.researchgate.net/profile/Takeshi_Inoue2 [researchers_second_profile] => https://orcid.org/0000-0003-3289-4478 ) [original_article_reference_fields] => Array ( [publication_title] => Calcium ions in the aquatic environment drive planarians to food [journal_title] => Zoological Letters [publisher] => BMC [year] => November 2019 [subject] => zoology; physiology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Hzvhg6s_QZc [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/02/What-Makes-Flatworms-Hungry.mp4_snapshot_00.01_2021.08.13_16.33.58.png [figures] => https://iesresearch.solutions/wp-content/uploads/2021/02/calcium.png ) ) [184] => WP_Post Object ( [ID] => 21590 [post_author] => 154 [post_date] => 2021-02-18 11:51:16 [post_date_gmt] => 2021-02-18 03:51:16 [post_content] => [post_title] => A Closer Look at the Treehopper Helmet Structure [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => a-closer-look-at-the-treehopper-helmet-structure [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:23:53 [post_modified_gmt] => 2021-09-13 08:23:53 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21590 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GOTOH, Hiroki (後藤寛貴) [researchers_position] => Ecological Genetics Laboratory, National Institute of Genetics, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/02/Hiroki-Gotoh.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => morphogenesis; 3D structure; treehopper; membracidae; pronotum; micro-CT, scanning electron microscopy [graphic_abstract] => [video] => [the_novelty] =>

This study lays out the details of the complex 3D structural development of the treehopper helmets through a series of experimental observations. The observations were conducted using micro-CT, scanning electron microscopy (SEM), and paraffin sections on the treehopper species called Antianthe expansa, which possesses a roof-shaped helmet. The key developmental stage for the treehopper helmet formation is identified as the formation of the miniature taking place during the final instar nymph. Typically, the formation of the 3D helmet involves two prominent structural transitions. Firstly, the monolayer epithelial sheets fold into a miniature helmet, signifying the bi-layer structure formation. This transition is also said to be identical to the development of insect wings. Next, the miniature helmet expands to form the macro- and micro-furrows, which indicates the growth in helmet size. Ultimately, these features serve as a defense mechanism and camouflage tool for the treehoppers.

[the_background] =>

The 3D helmets of treehoppers come in different shapes and styles, and it is usually visible as the final instar nymphs shed their exoskeleton to become adults. The transformation from simple to complex helmet structure within a short period intrigued many researchers. As a result, past literature has provided evidence of the two-stage structural transition occurring during this period. However, there are still uncertainties to the actual development of the structure. Therefore, this study aims to map out the development trajectory of the 3D helmet structure of the treehoppers.

[the_sdg_impact] =>

Studies on the structural development of insects, especially the evolution of the wings and horns, have led to a number of useful technological or architectural innovations. Similarly, the transition of the 3D helmet structure of treehopper through the folding-and-extension model observed in this study could inspire future innovations. Cross-application of such knowledge in terms of upgrading existing infrastructure and technological capabilities would certainly benefit society. Thus, contributing to the realization of UN SDG 9: Industry, innovation, and infrastructure through the integration of nature, science, and community.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-00155-7 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/02/treehoppers.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/02/Hiroki-Gotoh_4698982_1613620197.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-020-00155-7 [original_article_reference_fields] => Array ( [publication_title] => Structure and development of the complex helmet of treehoppers (Insecta: Hemiptera: Membracidae) [journal_title] => Zoological Letters [publisher] => BMC [year] => February 2020 [subject] => Zoology; Ecology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/zk8ox8Kr670 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/02/A-closer-look-at-the-treehopper-helmet-structure.mp4_snapshot_00.01_2021.06.01_20.35.22.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/02/treehoppers3.png ) ) [185] => WP_Post Object ( [ID] => 21577 [post_author] => 154 [post_date] => 2021-02-08 15:50:46 [post_date_gmt] => 2021-02-08 07:50:46 [post_content] => [post_title] => Reasons Behind Mixed Broods of Right- and Left-handed Snail Siblings [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => reasons-behind-mixed-broods-of-right-and-left-handed-snail-siblings [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:24:53 [post_modified_gmt] => 2021-09-13 08:24:53 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21577 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ASAMI, Takahiro (浅見崇比呂) [researchers_position] => Department of Biology, Shinshu University, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/02/Takahiro-Asami.png [researchers_profile] => https://www.researchgate.net/profile/Takahiro_Asami [researchers_second_profile] => https://orcid.org/0000-0002-8574-5989 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => left right; aplysia californica; bradybaena similaris; wild type; gastropod; biomphalaria glabrata; Spiral cleavage; pulmonate gastropod; pond snail; bradybaena; pulmonate; gene duplication [graphic_abstract] => [video] => [the_novelty] =>

Clockwise-coiled (dextral) and counterclockwise-coiled (sinistral) snails are reversed in bilateral asymmetry as well as in coiling direction. The classical model of maternal inheritance, resulting from a maternal effect of the dextral or sinistral allele with complete dominance at a nuclear locus, predicts that a mother produces either dextral or sinistral offspring but not both. This led to a belief that the reversed phenotype represents mutation of the wild-type allele to the other for the opposite handedness. However, a mutant of a dextral land snail Bradybaena similaris generates both dextral and sinistral progeny instead of sinistrals only. This study discovered that this racemism results from a defect in maternal expression of one of the diaph gene duplicates encoding diaphanous related formins, with no causative mutation in the gene itself. This provides a crucial basis for identification of a gene that allows for handedness determination by controling diaph expression.

[the_background] =>

Most multicellular animals (Bilateria) possesses left-right polarity in body architechture. They are externally symmetric but internally asymmetric, for example in visceral structure. No reversal in this handedness is found between species, except in snails. Fertilized eggs of dextral and sinistral snails develop in reverse depending on a maternal substance present in egg cytoplasm. It has accordingly been believed that sibling eggs produced by the same mother could develop to be either dextral or sinistral. This study was conducted to identify a mechanism that is responsible for an extraordinary feature of producing both dextral and sinistral progeny against the classical model of genetics and development of snail handedness.

[the_sdg_impact] =>

This study resolves fundamental questions on the genetic diversity and mechanism of body archtecture evolution. The outcome thus provides a comprehensive knowledge basis that critically contributes to realization of both SDG 14: Life below Water and SDG 15: Life on Land focusing on the agenda to protect and restore sustainable biodiversity in marine and terrestrial ecosystems.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-018-0120-0 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/02/Bradybaena-similaris.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/02/Takahiro-Asami_4484343_1612762325.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-018-0120-0 [original_article_reference_fields] => Array ( [publication_title] => Heterochirality results from reduction of maternal diaph expression in a terrestrial pulmonate snail [journal_title] => Zoological Letters [publisher] => BMC [year] => January 2019 [subject] => Zoology; Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/hNHb9CnBYEw [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-15.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/02/snail.png ) ) [186] => WP_Post Object ( [ID] => 21554 [post_author] => 154 [post_date] => 2021-02-03 10:18:51 [post_date_gmt] => 2021-02-03 02:18:51 [post_content] => [post_title] => Right Whale Fossil - Remnants of the Taiwan Ice Age [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => right-whale-fossil-remnants-of-the-taiwan-ice-age [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:26:25 [post_modified_gmt] => 2021-09-13 08:26:25 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21554 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TSAI, Cheng-Hsiu (蔡政修) [researchers_position] => Department of Life Science & Institute of Ecology and Evolutionary Biology, National Taiwan University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/02/Cheng-Hsiu-Tsai-.png [researchers_profile] => https://www.researchgate.net/profile/Cheng-Hsiu_Tsai [researchers_second_profile] => https://orcid.org/0000-0003-3617-366X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => southern hemispheres; biotic interchange; baleen whale; eschrichtius robustus; fossil; tympanic bulla; right whale; antitropical distribution; pleistocene; north pacific; Cetacea; eubalaena; Biogeography; The Pacific Ocean [graphic_abstract] => [video] => [the_novelty] =>

The discovery of an Ice Age (Pleistocene) right whale fossil (NTUM-VP 190807) reported in this study provides the first evidence of biotic interchange between two hemispheres. Such distribution dynamics are hypothesized to be the result of glacial and interglacial periods during the Ice Age. The fossil was initially recovered by the fishermen from the shallow sea bed of the Taiwan Strait during the trawling operations. Based on the morphology, the specimen is said to match that of the Eubalaena spp. Looking at the region the specimen was found, the species most likely existed on the southern margin of the western North Pacific during the glacial period, or it might have existed during the interglaciation as an extra-limital occurrence. Currently, the specimen dredged is broadly dated to the Middle to Late Ice Age; however, further research is required for clarification due to the lack of existing evidence to date the exact age of fossils. Future research should focus on uncovering more fossils of the Ice Age to deepen the evolutionary knowledge of past biodiversity that is the key to deciphering the origin of present biodiversity.

[the_background] =>

The right whales (Eubalaena spp.) are widely known as antitropical species largely inhabiting the temperate waters in the Northern and Southern hemispheres. Yet, some of its existence has been traced closer to the Equator. The discovery and documentation of the fossil (NTUM-VP 190807) is substantial to fill the literature gap on Eubalaena in terms of morphology, geographical distribution, migration pattern, and precise age dating. Even though lack of proper evidence of geological dating of specimens retrieved from the Taiwan Straits, this discovery sheds new light on the great biotic interchange between two hemispheres. It should also pave the way for revealing more untold and uncertain evolutionary histories and ecological interactions in the Ice Age.

[the_sdg_impact] =>

By understanding the marine megafaunal evolution such as the right whales’ (reaching 18 m long), insights into the evolution of the ecological system and its service would be enriched. To a large extent, this improved knowledge would be essential to future policymaking and conservatory efforts in regards to the marine ecology, meeting the objectives of the 14th UN Sustainable Development Goal, Life below water. Similarly, this study on the geographical distribution of the marine megafauna could potentially shed some light on the climate change effect of the past. Thus, coinciding with the drafting of efforts to tackle climate change issues of the present to achieve the targets of the 13th UN Sustainable Development Goal, Climate Action.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0153-z [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/02/right-whale.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/02/Cheng-Hsiu-Tsai_4380607_1612318362.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0153-z [original_article_reference_fields] => Array ( [publication_title] => A right whale (Mysticeti, Balaenidae) from the Pleistocene of Taiwan [journal_title] => Zoological Letters [publisher] => BMC [year] => December 2019 [subject] => Zoology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/q1t53mjOl7k [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/02/Right-Whale-Fossil-Remnants-of-the-Taiwan-Ice-Age.mp4_snapshot_00.01_2021.06.01_15.20.47.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/02/fossil.png ) ) [187] => WP_Post Object ( [ID] => 21530 [post_author] => 154 [post_date] => 2021-01-31 22:11:49 [post_date_gmt] => 2021-01-31 14:11:49 [post_content] => [post_title] => Breeding Rare Oarfish Larvae in the Lab [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => breeding-rare-oarfish-larvae-in-the-lab [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:27:28 [post_modified_gmt] => 2021-09-13 08:27:28 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21530 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => OKA, Shin-ichiro (岡慎一郎) [researchers_position] => Department of Zoological Laboratory, Okinawa Churashima Foundation, Japan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/01/Shin-ichiro-Oka.png [researchers_profile] => https://www.researchgate.net/profile/Shin_Ichiro_Oka2 [researchers_second_profile] => https://orcid.org/0000-0002-9554-6342 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => sea serpent; regalecus russelii; regalecus; artificial insemination; artificial fertilization; deep-sea fish; pectoral fin [graphic_abstract] => [video] => [the_novelty] =>

This study reports the first successful artificial insemination in oarfish (Regalecus russelii) using eggs and sperms from a dead pair of matured fishes. The findings of this study also provide the first reliable development record of ray-finned fish (Lampridiformes) from the fertilization stage to the early larval stages. Based on the observation of the hatched larvae, the morphological features are identified to be similar to the previously documented features of other ray-finned fish larvae. Since the captive conditions vary significantly from the natural habitat and there is a lack of knowledge in terms of the larvae' feeding behavior, none survived past 4 days after the hatching. With that said, the progress achieved by this study in artificial insemination technique is a huge leap in the field of science. Furthermore, the data collected through the fertilization to the hatching of the oarfish larvae certainly provides valuable insights into the development of the rare species.

[the_background] =>

Oarfish, Regalecus russelii, is a rare species found in the deep seas from tropical to temperate zones. Little is known of the history and morphological features of this species. In fact, most of the currently available information is said to be inaccurate due to insufficient sampling, misidentification, and failure in preserving the specimens. This study intends to provide an accurate understanding of the fertilization mechanism and larvae development of oarfish by artificially inseminating the eggs and sperms of the dead mature male and female oarfish.

[the_sdg_impact] =>

Apart from being naturally rare, studying the oarfish in its preferred natural habitat is also quite difficult. Thus, very little is known about its population, biological characteristics, feeding and mating patterns, etc. However, the findings of this study have shed some light on understanding the fertilization process and larvae morphology. This knowledge would potentially be useful in addressing marine environment degradation or fishing patterns that could harm the survival of this creature. Therefore, contributing well to the realization of the UN SDG 14: Life below water, which emphasizes the conservation and sustainable usage of the oceans and marine resources. Moreover, the successful attempt of the study in artificial insemination presents a promising future for aquaculture, indirectly contributing to the world hunger solution as envisioned in the targets of UN SDG 2: Zero hunger.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-00156-6 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/01/oarfish.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/01/Doekele-G.-Stavenga_4320827_1612101783.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-020-00156-6 [original_article_reference_fields] => Array ( [publication_title] => First observation of larval oarfish, Regalecus russelii, from fertilized eggs through hatching, following artificial insemination in captivity [journal_title] => Zoological Letters [publisher] => BMC [year] => April 2020 [subject] => Zoology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/ePEusJH7YrQ [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/01/Breeding-rare-oarfish-larvae-in-the-lab.mp4_snapshot_00.01_2021.06.01_11.50.33.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/01/oarfish4.png ) ) [188] => WP_Post Object ( [ID] => 21518 [post_author] => 154 [post_date] => 2021-01-31 21:38:11 [post_date_gmt] => 2021-01-31 13:38:11 [post_content] => [post_title] => Understanding the Wing Patterns of the Great Purple Emperor Butterfly [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => understanding-the-wing-patterns-of-the-great-purple-emperor-butterfly [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:28:31 [post_modified_gmt] => 2021-09-13 08:28:31 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21518 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => STAVENGA, Doekele [researchers_position] => Faculty of Science and Engineering, University of Groningen, Netherlands [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/01/Doekele-G.-Stavenga.png [researchers_profile] => https://www.researchgate.net/profile/Doekele_Stavenga [researchers_second_profile] => https://orcid.org/0000-0002-2518-6177 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => red scale; Spectrophotometry; scatterometry; red spot; wing scale; iridescence; structural coloration; thin films; margin [graphic_abstract] => [video] => [the_novelty] =>

This study provides a thorough structural and pigmentation pattern analysis of the wings of the Japanese male Great Purple Emperor butterfly (Sasakia charonda). A range of optical and anatomical approaches was used, namely light and electron microscopy, imaging scatterometry, and (micro)spectrophotometry, to better understand the patterns of wing scales and their effect on the coloration. The findings showed the influence of 3-OH-kynurenine, ommochrome, and melanin pigments in determining the wing colors when present in different concentrations and locations on the wings. A comparison between the species from Japan with other subspecies found in China and Korea displayed significant variation in the wing coloration, thus indicating the influence of different habitats on the morphology of the butterflies. An in-depth understanding of the mating behavior and survival properties of S. charonda could be established by analyzing its wings' makeup and coloration. The methods used in this study, as well as the knowledge gathered, will serve as a useful reference for the study of other insect species around the world.

[the_background] =>

Sasakia charonda, also known as the Great Purple Emperor, is a widely admired butterfly species for its beautiful purple-hued wings. The colors of its wings are among the important traits used to distinguish the gender of the species, where the male displays a brilliant bluish-purple hue while the female is duller. Apart from that, insects generally rely on such aesthetics to mate and as a defense mechanism. Hence, this study aims to look at the anatomy and various pigmentation patterns of the Great Purple Emperor found in Japan and its subspecies from China and Korea more closely. The findings contribute to understanding the diversity of the wing structure and color and its influence on the species survival.

[the_sdg_impact] =>

Butterflies are known for their colorfulness and are most welcomed into gardens compared to other insects. The variation in their wing patterns, their colors, and the structures that manipulate light has opened doors to inventions such as solar cell technologies among others. They can also play a significant role in ecology and economy by being pollinators of flowers and orchard crops. Therefore, a study on the structural makeup of the wings like this contributes to creative innovation and technological advancement as envisioned in the 9th United Nations’ Sustainable Development Goal, which focuses on building resilient infrastructures and fostering innovation.

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-00164-6 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/01/butterfly.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/01/Shin-ichiro-Oka_4320502_1612099523-1.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-020-00164-6 [original_article_reference_fields] => Array ( [publication_title] => Coloration principles of the Great purple emperor butterfly (Sasakia charonda) [journal_title] => Zoological Letters [publisher] => BMC [year] => November 2020 [subject] => Zoology; Entomology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/ipNaee_dH5M [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-17.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/01/Sasakia-scaled.jpg ) ) [189] => WP_Post Object ( [ID] => 21466 [post_author] => 154 [post_date] => 2021-01-30 13:25:54 [post_date_gmt] => 2021-01-30 05:25:54 [post_content] => [post_title] => The First-Ever 3D Imaging of the Internal Structures of Water Bears [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => the-first-ever-3d-imaging-of-the-internal-structures-of-water-bears [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:29:44 [post_modified_gmt] => 2021-09-13 08:29:44 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21466 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GROSS, Vladimir [researchers_position] => Department of Zoology, University of Kassel, Germany [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/01/Vladimir-Gross.jpg [researchers_profile] => https://www.researchgate.net/profile/Vladimir_Gross [researchers_second_profile] => https://orcid.org/0000-0001-7422-9148 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => X-ray nanoCT imaging; biological imaging; room temperature; filtered backprojection; Hypsibius exemplaris; spatial relationship; high resolution; Hypsibius dujardini; 3D reconstruction; computed tomography; tomography; tardigrada; water bear; anatomy [graphic_abstract] => [video] => [the_novelty] =>

In an attempt to produce a comprehensive three-dimensional (3D) visualization of the anatomy of tardigrades (water bears), this study managed to have the smallest whole animal imaged to-date using X-ray computed tomography (CT). The experiment was conducted using a nano-computed tomography device to image a 152 μm-long tardigrade at high resolution (200 – 270 nm pixel size). Upon visualizing the anatomy of the tardigrade in 3D, its internal structures were able to be mapped out accurately. The results allowed the direct measurement of volumes of the major structures and quantification of volume distribution of every storage cell without having to rely on geometrical approximations. With such a high-accuracy technique for volume measurement, this study proposed a future investigation to quantify the volume change of the midgut and to quantify how the volume of the ovary changes throughout the reproductive cycle.

[the_background] =>

Although the overall anatomy of tardigrades has been studied in detail for many decades, the literature lacked a comprehensive 3D visualization of the entire tardigrade anatomy, including volume measurements of individual structures. Thus, a reconstruction of such is essential to truly understand the spatial relationships of the tardigrade body structures. With the aid of a high-resolution X-ray nanoCT imaging instrument, the microscopic scale of tardigrades was no longer a hurdle to the 3D imaging process. As a result, the internal structures of the tardigrade can be examined in detail to measure their volume. The output of this study showed the increasing importance of tomographic imaging in morphological studies, especially in investigating microinvertebrates.

[the_sdg_impact] =>

Computed Tomography (CT) technology has been extensively used in imaging studies of larger research animals such as dogs and nonhuman primates but hardly on micro-scaled organisms. However, this study proved otherwise through its innovative usage of high-resolution X-ray nanoCT to successfully produce a detailed 3D visualization of the entire tardigrade anatomy. Thus, the techniques and findings of this study could potentially unleash more innovations in the field of animal research (SDG 9: Industry, Innovation and Infrastructure).

[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0130-6 [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/01/tardigrades.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2021/01/Vladimir-Gross_4299819_1611984195.mp3 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1186/s40851-019-0130-6 [original_article_reference_fields] => Array ( [publication_title] => X-ray imaging of a water bear offers a new look at tardigrade internal anatomy [journal_title] => Zoological Letters [publisher] => BMC [year] => May 2019 [subject] => Zoology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/r1sIvq-duto [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-3.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2021/01/figure1.png ) ) [190] => WP_Post Object ( [ID] => 21279 [post_author] => 154 [post_date] => 2020-12-29 21:22:49 [post_date_gmt] => 2020-12-29 13:22:49 [post_content] => [post_title] => Ballistic Performance of Basalt Fiber Laminated Composites [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => ballistic-performance-of-basalt-fiber-laminated-composites [to_ping] => [pinged] => [post_modified] => 2021-05-11 14:37:21 [post_modified_gmt] => 2021-05-11 06:37:21 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21279 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NATARAJAN, David [researchers_position] => Department of Mechanical Engineering, Universiti Teknologi MARA, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/1516945327403.jpg [researchers_profile] => https://www.researchgate.net/profile/Nv_David/2 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Composite materials; Fibers; Textiles; Body armor; Ammunition; Damage, Glass; Military systems; Rocks; Synthetic fibers; Tensile strength; Testing performance; Weapons [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/12/2-01-scaled.jpg [video] => [the_novelty] =>

This research presents the findings of V50 ballistic performance and the penetration resistance of basalt-fiber laminated composites. Using threat Level II of the National Institute of Justice (NIJ) Standard-0101.04 as penetration velocity reference, an ideal number of layers of basalt fabric to be woven is determined. Based on the tensile test, three different combinations of ply orientations are established to provide the best tensile strength and bullet penetration resistance.

[the_background] =>

Ballistic fabrics made from high performance fibers such as para-aramid (synthetic) and basalt (natural) fibers, and composites utilizing these fabrics, are among the leading materials for soft body armor systems. Military and law enforcement operations need durable, lightweight, damage and moisture-resistant ballistic fabrics with superior energy absorbing capacity. Basalt fibers, which are extracted from igneous volcanic rocks, are natural fibers with mechanical and thermo-physical properties that are generally comparable or superior to glass and other synthetic fibers but at a lower cost. This gives basalt-based composites a performance edge over existing material systems for potential application as anti-ballistic body armor.

[the_sdg_impact] =>

The demand of law enforcement protection is particularly high owing to a significant rise in crime rates and incidents of mass shooting in recent years. In line with the UN’s 16th SDG and taking into consideration the concerning rise of homicide rate, researchers are stepping in to protect the law enforcement personnel in the line of fire by working on a more cost-effective bulletproof vests with superior mechanical properties.

[article_url] => https://asmedigitalcollection.asme.org/IMECE/proceedings-abstract/IMECE2017/58448/V009T12A056/262004 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/volcanic-rocks.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/12/david_3674334_1609247659.mp3 [doi] => https://doi.org/10.1115/IMECE2017-70903 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => V50 Ballistic Performance of Unidirectional Woven Basalt Fiber Laminated Composites [journal_title] => International Mechanical Engineering Congress and Exposition [publisher] => ASME [year] => January 2018 [subject] => Mechanical Engineering ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/6czGs7lYyMU [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-41.jpg ) ) [191] => WP_Post Object ( [ID] => 21076 [post_author] => 154 [post_date] => 2020-12-27 15:44:22 [post_date_gmt] => 2020-12-27 07:44:22 [post_content] => [post_title] => Understanding Luminescence Properties of ZnO Fine Particle [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => understanding-luminescence-properties-of-zno-fine-particle [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:31:40 [post_modified_gmt] => 2021-09-13 08:31:40 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21076 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PANATARANI, Camellia [researchers_position] => Department of Physics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/24.jpg [researchers_profile] => https://www.researchgate.net/profile/Camellia_Panatarani [researchers_second_profile] => https://orcid.org/0000-0001-9936-8574 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => ZnO; spray pyrolysis; fine particle; zinc oxide; Luminescence; x-ray diffraction; scanning electron microscopy [graphic_abstract] => [video] => [the_novelty] =>

The wide bandgap within a zinc oxide (ZnO) compound makes it an ideal material to be used in semiconductor devices. This research provides experimental evidence of successful tailoring of oxygen vacancies in ZnO fine particles through a simple process. The spray pyrolysis technique was used to control the number of oxygen vacancies in ZnO. A correlation between the introduction of divalent and trivalent dopants into ZnO and its luminescence properties was established. The trivalent ions carry a higher rate of impurities; therefore, it is found to produce a stronger intensity of luminescence when introduced into ZnO. The results of this research also proved the possibility of altering the luminescence intensity of the compound by adjusting the light source even though under fixed oxygen vacancies.

[the_background] =>

Zinc oxide (ZnO) is easily found making up various electrical devices such as optoelectronic and spintronic devices, photovoltaic, gas sensors, photodetector, lighting displays, and many more due to its ideal chemical composition. Though commonly studied to improve the performance of semiconductors, no clear correlation has been established between the amount of oxygen vacancy and the luminescence spectra of ZnO. This research filled the gap by analyzing the luminescence properties of doped ZnO in terms of near band edge emission (NBE) and deep level emission (DLE), and the effects based on its oxygen vacancies.

[the_sdg_impact] =>

ZnO is largely regarded for its fascinating band structure and is being used in 50 to 60 percent of the industries today. Its function expands beyond semiconductors, proving its usefulness as nanoparticles as well as in the production of skin ointment and sunblock creams. The findings of this research contribute further in understanding this compound, encouraging future innovation and upgrades in the technological capabilities of industrial sectors worldwide. Hence, the research proves relevant to achieving UN SDG 9: Innovation and Infrastructure.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0921883120301795?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/Untitled-24.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/12/Camellia-Panatarani_1133773_1597567625.mp3 [doi] => https://doi.org/10.1016/j.apt.2020.04.024 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The effects of divalent and trivalent dopants on the luminescence properties of ZnO fine particle with oxygen vacancies [journal_title] => Journal of Advanced Powder Technology [publisher] => Elsevier [year] => July 2020 [subject] => Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/n8fi-xrCI7Y [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/12/Understanding-luminescence-properties-of-ZnO-fine-particle.mp4_snapshot_00.01_2021.07.16_12.06.54.png [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/img-004-1.png ) ) [192] => WP_Post Object ( [ID] => 21060 [post_author] => 154 [post_date] => 2020-12-26 21:29:37 [post_date_gmt] => 2020-12-26 13:29:37 [post_content] => [post_title] => Effect of Haslea Nusantara’s Blue Pigment on Marine Organisms [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => effect-of-haslea-nusantaras-blue-pigment-on-marine-organisms [to_ping] => [pinged] => [post_modified] => 2021-05-29 16:54:06 [post_modified_gmt] => 2021-05-29 08:54:06 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=21060 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PRASETIYA, Fiddy [researchers_position] => Department of Marine Sciences, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/19.jpg [researchers_profile] => https://www.researchgate.net/profile/Fiddy_Prasetiya [researchers_second_profile] => https://orcid.org/0000-0001-6474-2319 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Vibrio harveyi; antibacterial agent; Mytilus edulis; marine organism; Isochrysis galbana; Toxicity; blue water; Antibacterial activity; Growth inhibition [graphic_abstract] => [video] => [the_novelty] =>

For the first time, this study documented that H. nusantara produces a marennine-like pigment that has almost similar traits to that of marennine pigment from H. ostrearia. Other than spectral characteristics, the effect of supernatant that contains the blue pigments (i.e., Blue Water, BW) from both species on several marine organisms and the bioactivity of BW was also investigated. By having these findings, future studies can be conducted to identify the optimal concentration of H. nusantara BW to be applied in the aquaculture field as a preventive or curative antipathogen without causing any adverse effect.

[the_background] =>

The commercial and industrial potential of microalgae has been gaining more attention in recent years. Studies have been carried out to discover their ability to synthesize secondary metabolites of interest (pigments, lipids, etc.) for biofuel, food, or pharmaceutical industry. Past studies have reported that the marennine pigment from H. ostrearia could bring advantages and also adverse effects in purified form and the form of BW. In other words, further studies are needed to connect the dots since the conclusion was difficult to be drawn based on the contradicting findings of different studies with different parameters. Besides aiming to contribute to the literature by further assessing the marennine from H. ostrearia, this study also examined the marennine-like pigment from H. nusantara as part of the effort to search for a prophylactic agent for tropical aquaculture by using a tropical species.

[the_sdg_impact] =>

As the current terrestrial resources are exhausting, it is necessary to discover alternatives to keep nature in balance. Microalgae are known to carry a certain level of commercial and industrial potential. Aligned with the UN’s target to improve ocean health and enhance the contribution of marine biodiversity to the development of a developing country like Indonesia, the findings from this study would help to achieve Goal 14: Life below water, of Sustainable Development Goals of UN.

[article_url] => https://www.sciencedirect.com/science/article/pii/S2352513419305460?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/Untitled-19.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/12/Fiddy-Prasetiya_1094384_1597384153.mp3 [doi] => https://doi.org/10.1016/j.aqrep.2020.100389 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Effect of the blue pigment produced by the tropical diatom Haslea nusantara on marine organisms from different trophic levels and its bioactivity [journal_title] => Journal of Aquaculture Reports [publisher] => Elsevier [year] => July 2020 [subject] => Aquaculture; Marine Sciences ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/ruBZj-MhCk8 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/12/42-w-subs-music.mp4_snapshot_00.01_2021.05.12_10.30.43.jpg ) ) [193] => WP_Post Object ( [ID] => 20959 [post_author] => 154 [post_date] => 2020-12-18 08:38:50 [post_date_gmt] => 2020-12-18 08:38:50 [post_content] => [post_title] => Can Religion and Self-control be Used to Predict Antisocial Behaviors? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => can-religion-and-self-control-be-used-to-predict-antisocial-behaviors [to_ping] => [pinged] => [post_modified] => 2021-09-20 15:35:58 [post_modified_gmt] => 2021-09-20 07:35:58 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20959 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PURWONO, Urip [researchers_position] => Department of Psychology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/52.jpg [researchers_profile] => https://www.researchgate.net/profile/Urip_Purwono [researchers_second_profile] => https://orcid.org/0000-0002-6629-8300 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Bayesian information criterion; effortful control; muslim population; self regulation; Islam; theoretical model; religiosity; self control; antisocial behavior; self-control [graphic_abstract] => [video] => [the_novelty] =>

Based on past research theories, this study provides an overview of the relationship between religiosity and adolescents’ self-control as well as antisocial behavior. Since most of the available literature focused heavily on the relations between religiosity and self-control among U.S. Christian populations, this study gives insights into the Muslim adolescent community. Thus, assessing the generalizability of the models relating religiosity and EC to a wider sample. Apart from that, two types of adolescent antisocial behaviors, namely problem behavior and aggressive behavior, were assessed. Furthermore, the study compared moderation and mediation models and their relative adequacy by assessing the Bayesian Information Criterion (BIC) values. The results indicated that the moderation models were superior to the mediation models. A negative association between both religiosity and self-control and antisocial behavior was established. However, religiosity and self-control were indeed found to be interrelated.

[the_background] =>

The relationship between religiosity and self-control has been widely discussed, and there are often contradicting perceptions of their relation. Some studies agreed that they are interrelated, while others argued that they are not. It is also found that some of the findings cannot be replicated across studies, and there is an unevenness in the results across different types of antisocial behavior. Hence, this study aims to provide additional constructs in models connecting religiosity and adjustments by exploring religiosity and self-control as predictors of antisocial behavior.

[the_sdg_impact] =>

The United Nations have always been a strong advocate against violence and discrimination, especially in preserving equal rights across all religions. The rise in social unrest in recent years involving religion and culture serves as a strong indication that an in-depth understanding of the society and its principles are required to promote peace. The findings of this study could be beneficial in understanding the trigger of antisocial behaviors to ensure responsive, inclusive, participatory, and representative decision-making when it comes to educating the people and policymakers. Thus, aligning well with the visions of UNSDG 16: Peace, Justice and Strong Institution.

[article_url] => https://psycnet.apa.org/record/2018-27951-001 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/Untitled-52.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/12/Urip-Purwono_1758843_1600491748.mp3 [doi] => https://doi.org/10.1037/rel0000178 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Religiosity and Effortful Control as Predictors of Antisocial Behavior in Muslim Indonesian Adolescents: Moderation and Mediation Models [journal_title] => Journal Psychology of Religion and Spirituality [publisher] => American Psychology Association [year] => June 2018 [subject] => Psychology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/wYS-1jIz0rM [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/12/52-w-subs-music.mp4_snapshot_00.01_2021.05.12_11.07.10.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/img-000-4.png ) ) [194] => WP_Post Object ( [ID] => 20931 [post_author] => 154 [post_date] => 2020-12-17 03:48:05 [post_date_gmt] => 2020-12-17 03:48:05 [post_content] => [post_title] => Childhood Abuse History Triggers Depression in Adolescent [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => childhood-abuse-history-triggers-depression-in-adolescent [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:35:24 [post_modified_gmt] => 2021-09-13 08:35:24 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20931 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => DHAMAYANTI, Meita [researchers_position] => Department of Child Health, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/48.jpg [researchers_profile] => https://www.researchgate.net/profile/Meita_Dhamayanti [researchers_second_profile] => https://orcid.org/0000-0001-9661-0708 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => high school; sexual violence; Depression; mental health problem; Statistical Package for the Social Sciences; Adolescents; psychological violence; school student; junior high; meta analysis; Child abuse; indonesia [graphic_abstract] => [video] => [the_novelty] =>

This study provided evidence that a history of child abuse or another term violence against children (VAC) is associated with depression in adolescents of West Java, Indonesia. There were 5 dimensions of child abuse (VAC) history observed, namely psychological violence, exposure to violence, physical violence, neglect, and sexual abuse. Based on the outcome of this cross-sectional study, it was found that a history of psychological VAC had the highest risk of developing depression in later years. However, the other dimensions of VAC did portray significant influence in triggering depression. Therefore, it is crucial to implement early detection measures to prevent violence against children during the early years of a person and its consequences on mental health.

[the_background] =>

Depression is one of the common mental health problems observed during adolescence. If left unattended, it may cause dire consequences on themselves, their family, and even the nation. Previous studies have suggested a linkage between violence against children history and the prevalence of depression in later years. As this study proves a similarly strong correlation between the abuse history and depression in the Indonesian context, these findings could serve as a vital reference for practitioners when attending to such cases in the future.

[the_sdg_impact] =>

Globally, there are more than 264 million people of all ages suffering from depression. WHO also shared that close to 800 000 people die every year from suicide as a consequence of depression, making it the 2nd leading cause of death among 15 to 29-year olds. By understanding the factors triggering depression among school-goers, and their childhood history, effective preventive measures could be implemented. This study aligns perfectly with UN SDG 3: Good health and well-being to promote mental well-being across all ages.

[article_url] => https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-020-02218-2 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/Untitled-48.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/12/Meita-Dhamayanti_1708988_1600263526.mp3 [doi] => https://doi.org/10.1186/s12887-020-02218-2 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The association of depression with child abuse among Indonesian adolescents [journal_title] => Journal Behavior and Development [publisher] => BMC Pediatrics [year] => June 2020 [subject] => Pediatrics; Child Health ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/pNxouJods9M [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-13.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/img-000-3.png ) ) [195] => WP_Post Object ( [ID] => 20919 [post_author] => 154 [post_date] => 2020-12-16 19:54:49 [post_date_gmt] => 2020-12-16 19:54:49 [post_content] => [post_title] => Asthma: Its Modifiable Factors & Vulnerable Time Windows [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => asthma-its-modifiable-factors-vulnerable-time-windows [to_ping] => [pinged] => [post_modified] => 2021-05-11 14:40:11 [post_modified_gmt] => 2021-05-11 06:40:11 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20919 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HWANG, Bing-Fang (黃彬芳) [researchers_position] => Department of Occupational Safety and Health, College of Public Health, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/fang.jpg [researchers_profile] => https://www.researchgate.net/profile/Bing-Fang_Hwang [researchers_second_profile] => https://orcid.org/0000-0002-5951-9662 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => outdoor air pollution; postnatal period; Asthma; prenatal; Distributed Active Archive Center; air pollution; postnatal; aerosol optical depth; hazard ratios; socioeconomic status; particulate matter; cloud fraction; gestational week; Moderate Resolution Imaging Spectroradiometer [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/12/1-s2.0-S0091674919304798-fx1.jpg [video] => [the_novelty] =>

The findings of this study were to showcase the correlation between exposure of atmospheric pollutants called particulate matter (PM) during pre- and post-natal periods and the development of asthma. It used a comprehensive nationwide birth cohort database to evaluate the association of asthma with the PM2.5 (particulate matter with an aerodynamic diameter less than 2.5 µm) exposure during pregnancy and infancy in Taichung City. The results showed that the increased incidence of asthma in Taichung City was indeed associated with increased exposure to PM2.5 during pregnancy and infancy. To be exact, the vulnerable time windows reported during pregnancy were weeks 6 to 22, and weeks 9 to 46 after birth. The precision of weekly vulnerable time windows observation was made possible with the usage of a novel satellite-based hybrid model used to monitor ground PM2.5 in their residential location of the study.

[the_background] =>

Asthma is a common chronic respiratory disorder caused by genetic and environmental factors. Though the development of asthma has been associated with exposure to air pollutants during and after pregnancy, such prevalence remained unclear in the Asian context. By identifying the most vulnerable time windows for the development of asthma, this study contributed proof to the existing literature that indeed, the exposure of PM2.5 during pregnancy and infancy leads to asthmatic incidence in future. Since the direction of this study is to identify concerning risk factors on illnesses, the methodology employed could serve as a guide for future research of similar field or scale. The findings of this study are crucial in preventing and reducing the number of asthma cases not just locally but also globally. Besides, as asthma is not curable after its onset, knowing the vulnerable time windows is essential to mitigate the effect of environmental factors. Among suggestions to steer clear of the risk of developing asthma in later years are for pregnant women and children to stay indoors as well as avoid inhalation of toxicants and allergens during those periods.

[the_sdg_impact] =>

WHO estimated that approximately 300 million people are currently asthmatic, and the rising trend suggests an alarming 400 million people are to be affected by 2025. Furthermore, it is the most common chronic disease found in children, and yet it is mostly underdiagnosed and undertreated. The ultimate purpose of this study aligns perfectly with “Goal 3: Good health and well-being” of the UN’s Sustainable Development Goals (SDG), which is to prevent and reduce the prevalence of non-communicable diseases, in this case, asthma. By identifying the harmful effects pollutants have on child health, this study could be used to emphasize the need to substantially reduce the fatality and illnesses from hazardous chemicals and air, water, and soil pollution and contamination.

[article_url] => https://www.sciencedirect.com/science/article/pii/S0091674919304798#undfig1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/asthma3.jpg [podcast] => [doi] => https://doi.org/10.1016/j.jaci.2019.03.024 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Fine particulate matter exposure during pregnancy and infancy and incident asthma [journal_title] => Journal of Allergy and Clinical Immunology [publisher] => Elsevier [year] => June 2019 [subject] => Occupational Safety and Health; Medical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/az5rXicuqw0 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-37.jpg ) ) [196] => WP_Post Object ( [ID] => 20862 [post_author] => 154 [post_date] => 2020-12-16 17:22:00 [post_date_gmt] => 2020-12-16 17:22:00 [post_content] => [post_title] => Sustainable Microbial-based Agricultural Technologies [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => sustainable-microbial-based-agricultural-technologies [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:37:08 [post_modified_gmt] => 2021-09-13 08:37:08 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20862 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NATH YADAV, Ajar [researchers_position] => Department of Biotechnology, Eternal University, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/2174e249-d02b-4520-be22-05c25f80165b_sm.png [researchers_profile] => https://www.researchgate.net/profile/Ajar_Nath_Yadav [researchers_second_profile] => https://orcid.org/0000-0002-6911-7050 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => reactive oxygen species; Pseudomonas aeruginosa; Biodiversity; Bacillus altitudinis; Miscanthus sinensis; Brachybacterium paraconglomeratum; Acinetobacter calcoaceticus; plant nutrient; Bacillus subtilis; Bacillus megaterium; chemical fertilizer; Biofertilizers; Litchi chinensis; Arabidopsis thaliana; Triticum aestivum; indole-3-acetic acid; Bacillus licheniformis; Pseudomonas alcaligenes; Fusarium proliferatum; eco friendly; plant growth; Azotobacter chroococcum; Pseudomonas putida; Bioresources; Pseudomonas koreensis; Bacillus amyloliquefaciens; Brassica napus; Bacillus pumilus; Achromobacter xylosoxidans; sustainable agriculture; soil fertility; Enterobacter cloacae [graphic_abstract] => [video] => [the_novelty] =>

This review highlights the use of more than 30 plant growth promoting (PGP) microbes as biofertilizers in agriculture. These diverse PGP microbes were categorized according to the types of nutrients supplied for plant growth, the different forms of commercial biofertilizers currently available, and their potential roles in expanding agrotechnology. As a chemical fertilizers substitute, PGP microbes' benefits goes beyond stimulating plant growth. These biofertilizers are also capable of bioremediating the surrounding ecosystem from pesticides and heavy metal pollution, increasing the nutritional values of the crops, and improving plants' abiotic stress coping mechanisms. Apart from the positive impacts on agricultural productivity and environmental sustainability, the application process is both simple and inexpensive. Though promising, issues like public awareness and production beyond laboratories need to be addressed before implementing these alternative strategies widely. Therefore, future researches could further explore these issues to perfect modern agriculture.

[the_background] =>

Since the dawn of agriculture, fertilizers have been used to nourish the soil to promote crop growth and increase yield. The conventionally used chemical fertilizers, though produces the desired results in a short period, its negative impact on the environment and consumer health has driven scholars to explore safer alternatives. Lately, biofertilizers using plant growth promoting (PGP) microbes has been recognized as a promising substitute. These microbial cultures contain essential components for nutrient management without jeopardizing the soil fertility and the environment. Thus, this article provides a compilation of PGP microbes and their functions to highlight the importance of biofertilizers as well as their implementation in modern sustainable agriculture.

[the_sdg_impact] =>

The continuous growth of the world population urges innovation efforts to be escalated to feed its people. With majority of the world's poor living in rural areas, agriculture becomes their central economic activity. Hence, there is a pressing need for knowledge and technological investment to both raise the incomes and increase sustainable food supply. Microbial biofertilizers are possibly the answer to eradicating hunger, achieving food security, improving nutrition, and promoting sustainable agriculture, as envisioned in United Nation's SDG 2: Zero Hunger. Such outcomes based on the implementation of this inexpensive modern technology in agriculture could also contribute to the realization of UNSDG 1: No Poverty via a secure food system. This eco-friendly method of nourishing the soil used for agriculture plays a huge role in reducing soil and water pollution, which has been caused by heavy usage of traditional chemical fertilizers. Thus, extending its impact to achieving the targets of SDG 6 and SDG 14 on protecting the water sources, SDG 12 on sustainable consumption and production, and last but not least, SDG 15 on land use and ecosystem preservation, as reported by the OECD Trade and Agriculture Directorate.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S1878818119318390?via%3Dihub#! [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/agricultre2.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/12/2994634_1606100809.mp3 [doi] => https://doi.org/10.1016/j.bcab.2019.101487 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Microbial Biofertilizers: Bioresources and Eco-friendly Technologies for Agricultural and Environmental Sustainability [journal_title] => Journal of Biocatalysis and Agricultural Biotechnology [publisher] => Elsevier [year] => January 2020 [subject] => Agriculture; Biotechnology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/img-000-2.png [research_highlights_video_thumbnail] => ) ) [197] => WP_Post Object ( [ID] => 20855 [post_author] => 154 [post_date] => 2020-12-16 17:02:17 [post_date_gmt] => 2020-12-16 17:02:17 [post_content] => [post_title] => Mechanism of Thrombin Triggering Human Lung Inflammation [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => mechanism-of-thrombin-triggering-human-lung-inflammation [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:39:02 [post_modified_gmt] => 2021-09-13 08:39:02 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20855 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LIN, Chien-Huang (林建煌) [researchers_position] => Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/lin.jpg [researchers_profile] => https://www.researchgate.net/profile/Chien_Huang_Lin [researchers_second_profile] => https://orcid.org/0000-0002-0916-8737 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => rapamycin; Signalling pathway; Mammalian target of rapamycin; horseradish peroxidase; fetal calf serum; chromatin immunoprecipitation; p70S6 kinase; enzyme-linked immunosorbent assay; Thrombin; chronic obstructive pulmonary disease [graphic_abstract] => [video] => [the_novelty] =>

This research provides evidence that thrombin is indeed involved in triggering inflammation in human lung cells through a cascade of biological signals. The findings showed thrombin activates the Akt pathway, which led to the phosphorylation of mTOR and p70S6K proteins. Consequently, a complex is formed between p70S6K, p300 (coactivator) and p65, which binds to the nuclear factor-κB (NF-κB). The activation of this NF-κB signaling pathway then induces the release of IL-8/CXCL8 in human lung epithelial cells, causing inflammation and thus confirming the critical role of mTOR and p70S6K in thrombin-induced human lung epithelial cell inflammation.

[the_background] =>

Although thrombin is commonly known for its function in blood clotting, studies have also shown that it plays an essential role in chronic lung inflammatory diseases. Previous studies have also reported that IL-8/CXCL8 (inflammatory chemokine) secretion is abundant in lung epithelial cells of asthmatic patients. However, the mechanism of thrombin stimulating the release of IL-8/CXCL8 was still unknown. Similarly, the roles of mTOR and p70S6K in the Akt pathway relating to the release of inflammatory chemokine when exposed to thrombin were also unclear. This research highlighted the pathway linking thrombin to the release of IL-8/CXCL8, in which, both mTOR and p70S6K were significantly involved. Hence, the findings provide a potential therapeutic target to treat chronic airway and lung inflammatory diseases.

[the_sdg_impact] =>

WHO reports over 339 million people are suffering from asthma globally, among which are mostly children. As of now, there isn’t any cure for it; instead, inhaled corticosteroids and appropriate management are commonly prescribed to control the progression of the disease. The research demonstrated the link between thrombin and the signaling pathways leading to lung inflammation. This could be used as a potential building ground for suitable drug development to control or even cure asthma. The significance of the findings complements the targets of the UN’s SDG 3: Good health and well-being, strengthening health research development to reduce premature mortality from non-communicable diseases like asthma.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0014299919308313?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/lung.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/12/Lin-Chien-Huang-2_2995459_1606105096.mp3 [doi] => https://doi.org/10.1016/j.ejphar.2019.172879 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells [journal_title] => European Journal of Pharmacology [publisher] => Elsevier [year] => February 2020 [subject] => Pharmacology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/img-000-1.png [research_highlights_video_thumbnail] => ) ) [198] => WP_Post Object ( [ID] => 20846 [post_author] => 154 [post_date] => 2020-12-16 16:52:16 [post_date_gmt] => 2020-12-16 16:52:16 [post_content] => [post_title] => Tuberculosis-causing Bacteria Activates Connective Tissue Proteins Through Novel Signaling Pathway [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => tuberculosis-causing-bacteria-activates-connective-tissue-proteins-through-novel-signaling-pathway [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:40:09 [post_modified_gmt] => 2021-09-13 08:40:09 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20846 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LIN, Chien-Huang (林建煌) [researchers_position] => Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/lin.jpg [researchers_profile] => https://www.researchgate.net/profile/Chien_Huang_Lin [researchers_second_profile] => https://orcid.org/0000-0002-0916-8737 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => epithelial cell; macrophage; extracellular matrix; small interfering RNA; tuberculosis; pulmonary fibrosis; fibrosis; matrix metalloproteinase; actinomycin D; activator protein 1; tissue remodeling; M.tb; Connective tissue growth factor; chromatin immunoprecipitation; mycobacterium tuberculosis; endothelin 1 [graphic_abstract] => [video] => [the_novelty] =>

This study presents novel insight on the action of Mycobacterium tuberculosis (M.tb), tuberculosis-causing bacteria on connective tissue growth factor (CGTF) in the lung and the signaling pathway involved leading towards pulmonary fibrosis. The pathway in which this occurs, as reported via in-vitro examination, involves the TLR2-JNK-AP-1 pathway, eventually leading to the expression of CGTF. The study also notes that the inducement of CGTF depends on time and concentration of M.tb. These promising findings open up avenues for treatment focused on inhibiting and preventing CGTF expression from causing lung fibrosis occurrence related to tuberculosis.

[the_background] =>

Pulmonary fibrosis is a known effect of tuberculosis characterized by scarring of the lung. Otherwise known as granuloma, this condition occurs over time, diminishes lung functions. Research has attributed this to the action of proinflammatory cytokine expression, a form of signaling protein activated via toll-like receptors (TLR), specifically TLR-2 and fibroblasts, a vital connective tissue cell where human tissue remodeling is a concern. CGTF is responsible for regulating production of the cell's skeletal component, the extracellular matrix (ECM), airway repair, and lung fibrosis progression via its key role in mediating these fibroblasts. Evidenced by animal model studies, excessive CGTF was found to be present in tissue fibrosis. The cell signaling mechanism by which CGTF is activated involves specific kinases (enzymes), such as Smad, ERK, and JNK-activator protein 1 (AP-1). Lack of understanding of how this pathway affects CGTF expression and ECM production fueled this study. This study specifies that M.tb activates a signaling cascade, beginning with TLR2 that activates JNK and c-Jun, causing AP-1 to be activated. As a result, CGTF and ECM protein fibronectin action were initiated and stimulated. This finding's significance is highly understated, given the potential of future tuberculosis intervention in inhibiting expression of CGTF while concurrently reducing lung fibrosis.

[the_sdg_impact] =>

A global report by the World Health Organization (WHO) stipulates a staggering 10 million deaths related to tuberculosis (TB). A large majority of 44% stemmed from the Southeast Asian region. United Nations member states have declared to end TB by 2030; however, tuberculosis's impact remains pressing among countries with high TB load, especially since the 2020 milestone could not be achieved. Nevertheless, novel findings and suggestions from this study aligns with the United Nations Sustainable Development Goal 3 (SDG3): Good health and well-being, contributing to the target of treating 30 million people with TB preventive treatment by 2022.

[article_url] => https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201900487R [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/tuber.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/12/Lin-Chien-Huang_2995318_1606104381.mp3 [doi] => https://doi.org/10.1096/fj.201900487R [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Mycobacterium tuberculosis induces connective tissue growth factor expression through the TLR2-JNK-AP-1 pathway in human lung fibroblast [journal_title] => FASEB [publisher] => Wiley Publishing [year] => August 2019 [subject] => Medical Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/img-000.png [research_highlights_video_thumbnail] => ) ) [199] => WP_Post Object ( [ID] => 20840 [post_author] => 154 [post_date] => 2020-12-16 16:25:52 [post_date_gmt] => 2020-12-16 16:25:52 [post_content] => [post_title] => Mechanism of FOXC1 in Regulating Neural Stem Cells’ Growth & Division [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => mechanism-of-foxc1-in-regulating-neural-stem-cells-growth-division [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:41:08 [post_modified_gmt] => 2021-09-13 08:41:08 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20840 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SHYU, Woei-Cherng (徐偉成) [researchers_position] => Graduate Institute of Biomedical Science, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/Woei-Cherng.jpg [researchers_profile] => https://www.researchgate.net/profile/Woei_Shyu [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => regions of interest; alkaline phosphatase; Chromatin immunoprecipitation; retinoic acid; forkhead box; stem cell; middle cerebral artery; von Willebrand factor; subventricular zone; ventricular zone; neural stem cells; microtubule-associated protein 2; mesenchymal stem cell; fetal calf serum; fluorescein isothiocyanate; cerebral blood flow; neural crest cell; glial fibrillary acidic protein; periodic acid Schiff; phosphate-buffered saline; mouse braine; mbryonic stem cells [graphic_abstract] => [video] => [the_novelty] =>

In an effort to explore the characteristics of neural stem cells, this study discovered a new role of forkhead box protein C1 (FOXC1) in regulating the developmental processes in the skull and brain. The mechanism in which FOXC1 involvement was highlighted via in vitro experiments conducted on arachnoid-pia stem cells (APSCs) isolated from humans and mice. FOXC1 was found to cause direct induction of stress-inducible protein 1 (STI-1) in APSCs. Then, the STI-1 stimulates cellular prion protein (PrPC) to promote the growth and division of APSCs. Such novel insights on the newly identified APSCs secreting STI-1 bring to light alternate signaling mechanism to create neural stem cells. In vivo studies shall be carried out in the future to confirm the potential of FOXC1 in healing patients within a shorter time frame.

[the_background] =>

FOXC1 is a single exon gene encoding a 553 amino acid protein and a member of the forkhead box (FOX) family of transcription factors. The meningeal layer is membranous coverings (consist of arachnoid-pia cells) of the brain and spinal cord. FOXC1 is known to play a crucial role in regulating developmental processes, including somatic, cardiovascular and renal development. Past studies also showed that mice with FOXC1 gene mutations displayed severe brain and skull defects. Nonetheless, those observations merely highlighted the relationship between FOXC1 and the meningeal layer. Thus, this study was carried out to investigate the regulatory mechanisms of FOXC1 in APSC proliferation and self-renewal. Understanding the mechanisms would contribute to advancing health technology, especially in developing procedures and systems for rapid healing purposes.

[the_sdg_impact] =>

WHO’s Global Initiative on Health Technologies aims to help make available the benefits of health technologies to effectively control health problems. The output of this study allows scientists to better understand how neural stem cells work. This opens up possibilities to develop technologies that treat and improve the condition of patients, especially those suffering from brain and skull defects. Therefore, this study provides foundational evidence to be further explored, ultimately contributing to the realization of UNSDG 3: Good Health & Well-being.

[article_url] => https://www.thno.org/v09p6443.htm [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/20b-1.jpg [podcast] => [doi] => https://doi.org/10.7150/thno.35619 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrPC signaling [journal_title] => Theranostics [publisher] => Theranostics [year] => August 2019 [subject] => Biomedical Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/oZFgWwA27EY [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-25.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/thnov09p6443g001.jpg ) ) [200] => WP_Post Object ( [ID] => 20833 [post_author] => 154 [post_date] => 2020-12-16 16:15:59 [post_date_gmt] => 2020-12-16 16:15:59 [post_content] => [post_title] => Lifespan Extension: A Novel Signaling Pathway [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => lifespan-extension-a-novel-signaling-pathway [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:42:26 [post_modified_gmt] => 2021-09-13 08:42:26 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20833 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HSU, Ao-Lin (許翱麟) [researchers_position] => Research Center for Healthy Aging, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/aolin.jpg [researchers_profile] => https://www.researchgate.net/profile/Ao-Lin_Hsu [researchers_second_profile] => https://orcid.org/0000-0002-2864-3134 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => green fluorescent protein; immunoglobulin G; life span; deoxyribonuclease I; insulin-like growth factor 1; untranslated regions; caenorhabditis; heat shock proteins; RNA interference; Caenorhabditis elegans; heat shock factor; mitochondrial genome; mitochondrial DNA; protein homeostasis; C. elegans; polymerase chain reaction; electron transport chain; micrococcal nuclease; phosphate-buffered saline; heat shock response; phenylmethylsulfonyl fluoride [graphic_abstract] => [video] => [the_novelty] =>

In attempt to establish an in-depth understanding of aging and organismal longevity, this study reported a novel signaling pathway that could extend life expectancy. The results showed that the longevity achieved in Caenorhabditis elegans (nematode worms) is largely due to the increase in histone H4 protein levels. The increase in histone H4 protein is induced by inhibiting the binding of heat shock factor binding protein 1 (HSB-1) to heat shock factor–1 (HSF-1). Consequently, the histone H4 proteins move from nucleus to mitochondrion and result in increased compaction of mitochondrial genome, subsequently inhibiting mitochondrial activity. Thus, contributing to the extension of lifespan. By leveraging the findings of this study, future research may be carried out in other multicellular organisms to explore its feasibility in terms of applications.

[the_background] =>

Multiple studies have shown that HSF-1 is actively involved in regulating the longevity of animals in non-stressed physiological conditions. It is found that the transcriptional activity of HSF-1 is inhibited by several regulatory mechanisms under normal conditions. One such negative regulator of HSF-1 is the HSB-1. Nonetheless, the longevity-promoting mechanisms of the HSB-1/HSF-1 signaling pathway remain uncertain to-date. Hence, this study investigated the signaling pathway, which also involves the crucial roles of H4. The outputs of the investigation would serve as a useful reference for future studies in longevity.

[the_sdg_impact] =>

The UN estimates a global average life expectancy of 72.6 years for 2019. Would it be possible to increase it to achieve that of Japan in the future (i.e., 84.7 years for 2019)? In order to achieve that, extensive studies are needed to help researchers understand the pathways and mechanisms involved in the human lifespan and aging. The results of this study are essential to help realize UN SDG 3: Good Health & Well-being, possibly allowing the world population to age gracefully.

[article_url] => https://advances.sciencemag.org/content/6/43/eaaz4452 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/lifespan2.jpg [podcast] => [doi] => https://doi.org/10.1126/sciadv.aaz4452 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity [journal_title] => Journal of Science Advances [publisher] => AAAS [year] => October 2020 [subject] => Aging; Health; Medical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Ppw9J3aoGyA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-20.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/F2.large-1.jpg ) ) [201] => WP_Post Object ( [ID] => 20822 [post_author] => 154 [post_date] => 2020-12-16 16:07:36 [post_date_gmt] => 2020-12-16 16:07:36 [post_content] => [post_title] => Prevention of Diet-induced Obesity and Diabetes via Engineered Tissues [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => prevention-of-diet-induced-obesity-and-diabetes-via-engineered-tissues [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:44:23 [post_modified_gmt] => 2021-09-13 08:44:23 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20822 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WANG, Chih-Hao (王志豪) [researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/wang2.jpg [researchers_profile] => https://www.researchgate.net/scientific-contributions/Chih-Hao-Wang-2144142600 [researchers_second_profile] => http://orcid.org/0000-0003-1704-1311 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => energy expenditure; soluble guanylyl cyclase; white adipose tissue; brown adipose tissue; endogenous; glucose homeostasis; endothelial nitric oxide synthase; adenosine monophosphate; analysis of variance; nitric oxide; uncoupling protein 1; Institute for Basic Science; Juvenile Diabetes Research foundation; brown fat; cyclic guanosine monophosphate; guanosine diphosphate; adipose tissue; insulin sensitivity; red blood cell [graphic_abstract] => [video] => https://www.youtube.com/embed/s57P2-SHIAw [the_novelty] =>

In order to curb obesity and diabetes, this study discovered a potential method using the CRISPR-SAM system to engineer human white adipose tissues (WAT) to exhibit the properties of brown adipose tissues (BAT). The reported findings were obtained from in vivo experiments conducted on obese mice. It was observed that, for both preventive and treatment models, the transplantation of human brown-like (HUMBLE) cells improved blood sugar regulation in mice with the aid of SNOs/nitrite activation. The unique effect of NO on BAT, when complemented with the HUMBLE cell-based therapy, could potentially be used as an alternate strategy to activate BAT by increasing NO bioactivity, in part, increasing eNOS activity in HUMBLE cells. The HUMBLE cell-based therapy suggested by this study promises a side-effect-free activation of BAT, sustainable improvement of metabolism for a prolonged period, and combat high-calorie diet-based metabolic disorders. To further solidify these findings, future experiments could focus on the effects of environmental factors, such as ambient temperature, diet, and housing condition.

[the_background] =>

In mammals, both WAT and BAT play crucial roles in systemic energy homeostasis. WAT is the main site for storing excess fuel containing unilocular lipid droplets, while BAT is specific for energy dissipation and has multilocular lipid droplets. BAT generates heat in response to cold exposure, and the activation of BAT increases energy expenditure. Meanwhile, the activity of BAT is inversely correlated with body mass index and fat mass, making BAT an appealing target for anti-obesity therapies. On the other hand, WAT is more easily reachable and manipulatable considering its abundance and location. Therefore, aiming for induced browning of WAT may hold great potential for preventing or treating obesity and obesity-related metabolic disorders. Even though some clinical studies have demonstrated that BAT can be activated effectively via cold exposure, therapeutic cold exposure is uncomfortable for patients. Furthermore, sympathomimetics drugs were reported to activate BAT but have unwanted cardiovascular side effects. This study was conducted to create human brown-like (HUMBLE) cells by engineering human white preadipocytes using the CRISPR genome editing approach

[the_sdg_impact] =>

According to WHO, over 340 million children and adolescents aged 5-19 were overweight or obese in 2016. Besides that, most of the world's population live in countries where overweight and obesity kill more people than underweight. Hence, establishing preventive and therapeutic methods to combat obesity and its complications is of great importance to the healthcare community. The output of this study provides a potential cell-based therapeutic strategy to combat obesity and metabolic syndrome. Its hand in reducing the overall health risk aids the realization of UN SDG 3: Good Health & Well-being.

[article_url] => https://stm.sciencemag.org/content/12/558/eaaz8664 [main_image] => [podcast] => [doi] => https://doi.org/10.1126/scitranslmed.aaz8664 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice [journal_title] => Science Translational Medicine [publisher] => AAAS [year] => August 2020 [subject] => Biomedical Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-31.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/img-004.png ) ) [202] => WP_Post Object ( [ID] => 20814 [post_author] => 154 [post_date] => 2020-12-16 15:50:47 [post_date_gmt] => 2020-12-16 15:50:47 [post_content] => [post_title] => Alternate Pain Management Strategy through Acupuncture [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => alternate-pain-management-strategy-through-acupuncture [to_ping] => [pinged] => [post_modified] => 2021-09-13 16:45:26 [post_modified_gmt] => 2021-09-13 08:45:26 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20814 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHEN, Yi-Hung (陳易宏) [researchers_position] => Graduate Institute of Acupuncture Science, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/yihung.jpg [researchers_profile] => https://www.researchgate.net/profile/Yi-Hung_Chen [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => enzyme immunoassay; area under the curve; pain management; phospholipase C; nerve stimulationan; algesia; electrical stimulation; Food and Drug Administration; low frequency; diacylglycerol lipase; periaqueductal gray; orexin a; lateral hypothalamus [graphic_abstract] => [video] => [the_novelty] =>

In efforts to improve the current pain management approach, this study has proven that median nerve stimulation (MNS) through acupuncture needles at the PC6 acupoint (MNS-PC6) induced a pain-relieving effect. This opioid-independent pain relief strategy was tested using mice models to understand the analgesic mechanism thoroughly. The findings revealed that electrical stimulation at PC6 acupoint (MNS-PC6) released neuropeptide orexin from the hypothalamus to inhibit pain responses in mice through an endocannabinoid. This neurotransmitter then reduced the GABAergic, an inhibitory control, in the periaqueductal gray (midbrain pain control region), effectively suppressing the pain intensity. Thus, introducing an alternate pain-management strategy, especially in opioid-tolerant patients. The effectiveness of the MNS shall be further confirmed by conducting tests on other pain models, such as pain associated with cancer, arthritis, or chronic inflammation.

[the_background] =>

Despite the fact that peripheral nerve stimulation (including MNS) and acupuncture have been applied in pain relief for over fifty years and thousands of years, respectively, their mechanisms remain uncertain to-date. There were also arguments stating that the pain-relieving effect of acupuncture is just a placebo effect. Meanwhile, on top of the potential risk of drug misuse, the current painkillers are known to cause significant adverse effects and limitations. These are the reasons for the inadequate treatment of pain, especially neuropathic pain and cancer pain. Hence, this study was conducted to not only demonstrate the efficiency of MNS-PC6, but also to outline the mechanism of pain relief effect induced in detail. Therefore, a thorough understanding of the mechanism would help practitioners improve the current state of pain management.

[the_sdg_impact] =>

WHO is concerned about the opioid overdose crisis and the potential hazards of drug abuse in the name pain management. Furthermore, people in low- and middle-income countries have minimal access to medication for moderate and severe pain control. Therefore, apart from improving the well-being of patients, the results of this study in inducing pain relief effectively via a nonopioid mechanism have high potential in strengthening the prevention and treatment of substance abuse. Essentially, the findings of this study set the path to realizing the objectives of UNSDG 3: Good Health & Well-being, especially in the healthcare industry

[article_url] => https://www.pnas.org/content/115/45/E10720 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/17c.jpg [podcast] => [doi] => https://doi.org/10.1073/pnas.1807991115 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Median nerve stimulation induces analgesia via orexininitiated endocannabinoid disinhibition in the periaqueductal gray [journal_title] => Neuroscience [publisher] => PNAS [year] => November 2018 [subject] => Medical; Acupuncture ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/hYKfkCsIpc0 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-26.jpg [figures] => https://iesresearch.solutions/wp-content/uploads/2020/12/F2.large_.jpg ) ) [203] => WP_Post Object ( [ID] => 20806 [post_author] => 154 [post_date] => 2020-12-16 15:33:56 [post_date_gmt] => 2020-12-16 15:33:56 [post_content] => [post_title] => Inhibiting the COVID-19 Protein using Curcuminoid Derivatives [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => inhibiting-the-covid-19-protein-using-curcuminoid-derivatives [to_ping] => [pinged] => [post_modified] => 2021-05-11 14:53:49 [post_modified_gmt] => 2021-05-11 06:53:49 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20806 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YANG, Jai-Sing (楊家欣) [researchers_position] => Department of Medical Research, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/Jai-Sing-Yang.jpg [researchers_profile] => https://www.researchgate.net/scientific-contributions/Jai-Sing-Yang-2046081404 [researchers_second_profile] => https://orcid.org/0000-0001-7302-8248 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => human immunodeficiency virus; compound library; novel coronavirus; 2019‐nCoV; Food and Drug Administration; lopinavir; Alzheimer disease; ribonucleic acid; coronavirus disease [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/12/10.1177_1934578x20953262-fig1.gif [video] => [the_novelty] =>

As an effort to battle the COVID-19 pandemic, this study identified curcuminoid derivatives that are capable of binding to 3C-like protease (3CLpro) and block the activity in SARS-CoV-2. The study was conducted using computer simulations (in silico) and the compound library of Natural Products Research Laboratories (NPRL). The curcuminoid derivatives identified to have a strong binding affinity to 3C-like protease (3CLpro) include NPRL334, NPRL339, NPRL342, NPRL346, NPRL407, NPRL415, NPRL420, NPRL472, and NPRL473, among which NPRL342 showed the strongest binding affinity. By leveraging these promising results, in vitro and in vivo experiments are being carried out to verify the anti-SARS-CoV-2 viral activity of the potential compounds followed by clinical trials.

[the_background] =>

On March 23, 2020, remdesivir was designated by the Food and Drug Administration (FDA) for compassionate use to treat COVID-19. Since remdesivir is one of the RNA-dependent RNA polymerase (RDRP) inhibitors, they were reported to appear nonspecific, display low potency, and cause common adverse reactions in patients. Meanwhile, Kaletra (lopinavir/ritonavir; a protease inhibitor) was administered to some COVID-19 patients, and health improvement was observed. This implies the potential of the main protease (3C-like protease; 3CLpro) as an essential target in COVID-19 therapy. Recently, curcumin has been demonstrated to have the ability to block the entry of SARS-CoV-2. Thus, this study was conducted to investigate whether 3CLpro can be a major target protein with strong binding affinities to lopinavir, curcumin, and compounds from the compound library of NPRL, via molecular docking techniques.

[the_sdg_impact] =>

As of the fourth quarter of the year 2020, the death toll of Covid-19 touches nearly 1 million worldwide, with over 30 million reported cases. Besides causing fatalities, this pandemic is severely affecting the global economy and increased the rate of unemployment. By conducting this study to discover an effective therapy for COVID-19, it contributes to the research and development of vaccines and medicines which improve the health and well-being of people (UNSDG 3).

[article_url] => https://journals.sagepub.com/doi/10.1177/1934578X20953262 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/16b.jpg [podcast] => [doi] => https://doi.org/10.1177/1934578X20953262 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => In Silico De Novo Curcuminoid Derivatives From the Compound Library of Natural Products Research Laboratories Inhibit COVID-19 3CLpro Activity [journal_title] => Journal Nature Product Communication [publisher] => Sage Publishing [year] => September 2020 [subject] => Medical; Covid-19 ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/sVNi9Xlg1ME [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-22.jpg ) ) [204] => WP_Post Object ( [ID] => 20675 [post_author] => 2 [post_date] => 2020-12-08 01:43:27 [post_date_gmt] => 2020-12-07 17:43:27 [post_content] => [post_title] => LaBr3(Ce) Detector Performance Upgrade: Understanding the Intrinsic Background Radiation [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => labr3ce-detector-performance-upgrade-understanding-the-intrinsic-background-radiation [to_ping] => [pinged] => [post_modified] => 2022-07-11 12:07:19 [post_modified_gmt] => 2022-07-11 04:07:19 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20675 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SUN, Baohua [researchers_position] => School of Physics, Beihang University, China [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/12/sun-baohua2.jpg [researchers_profile] => https://www.researchgate.net/profile/Baohua_Sun2 [researchers_second_profile] => https://orcid.org/0000-0001-9868-5711 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => secular equilibrium; coincidence measurement; background radiation; GEANT4 simulation; B380; decay chain; electronic capture; γ ray; clover detector; high-purity germanium [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/12/labre-detector.jpeg [video] => [the_novelty] =>

In an attempt to improve the efficiency of the cerium doped lanthanum (III) bromide (LaBr3(Ce)) detector, this study, for the first time, showcased the decoupling activities of thallium-207, polonium-211, polonium-215, francium-223, and actinium-227. It provided a complete picture of the detector’s intrinsic background through the α- and β-decay chain. This resulted from conducting a coincidence measurement using a Clover detector to identify the internal radioactive isotopes of the Ø3”×3” Saint-Gobain B380 detector. The combination of coincidence spectra with Geant4 simulations allowed the determination of accurate lanthanum-138, bismuth-211, radon-219, radium-223, and thorium-227 activities. Therefore, the findings of this study ultimately provided insights into the radioactive contaminants present in the detector and its influences on the detection sensitivity.

[the_background] =>

The LaBr3(Ce) crystal is a new inorganic scintillator that is ideal for being widely used in environmental monitoring, oil well logging, nuclear safeguards, and medical imaging. Its superior characteristics in terms of density, light output, temperature response, and decay time make it a favorable substitute for the widely used thallium doped sodium iodide (NaI(Tl)) when high performance is required. However, the LaBr3(Ce) detector is also known to have a relatively high intrinsic background radiation due to lanthanum-138 and actinium-227 impurities. As a result, it limits the application of this detector, especially in low-count rate experiments. Therefore, this study is crucial to understand and enhance the performance of the LaBr3(Ce) detector as well as maximize its potential across various fields.

[the_sdg_impact] =>

Innovation and technological advancement are known to be the key drivers of growth, whether it involves societal, economic, or environmental well-being. By encouraging new or improved technologies through research and development, as projected in UNSDG 9: Industries, Innovation and Infrastructure, a significant influence on global resource management, international trades, economic development, etc. would be feasible. Hence, the aim of this study, which is to improve the efficiency of the LaBr3(Ce) detector, is a step towards adopting innovation to overcome the limitations of existing technologies. The findings could be used to provide important parameters when laboratory-based systems are employed under open field environment. Thus, it will improve the on-field application of the scintillating material in terms of addressing radioactive contaminations or for medical purposes.

[article_url] => https://link.springer.com/article/10.1007/s41365-020-00812-8 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/12/radiation-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/12/Radiation_3277662_1607331672.mp3 [doi] => https://doi.org/10.1007/s41365-020-00812-8 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Intrinsic background radiation of LaBr3(Ce) detector via coincidence measurements and simulations [journal_title] => Nuclear Science and Techniques [publisher] => Springer Nature [year] => October 2020 [subject] => Nuclear Science; Physics; Engineering ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Ivs_UhU9tss [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-19.jpg [figures] => ) ) [205] => WP_Post Object ( [ID] => 20468 [post_author] => 1 [post_date] => 2020-11-04 15:03:19 [post_date_gmt] => 2020-11-04 15:03:19 [post_content] => [vc_row][vc_column][vc_basic_grid post_type="ieresearch" max_items="10" grid_id="vc_gid:1606120954692-98b50eb8-ac2e-8" taxonomies="21, 26"][/vc_column][/vc_row] [post_title] => Creating Energy Efficient LEDs [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => creating-energy-efficient-leds [to_ping] => [pinged] => [post_modified] => 2022-07-08 10:46:30 [post_modified_gmt] => 2022-07-08 02:46:30 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20468 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SHUHAIMI, Ahmad [researchers_position] => University of Malaya | UM · Department of Physics [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/09/ahmad.png [researchers_profile] => https://www.researchgate.net/profile/Ahmad_Shuhaimi [researchers_second_profile] => https://orcid.org/0000-0003-0552-9395 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Gallium Nitride; Multi-layer; Semi-polar; Surface Morphology; Thin Film; Diffuse Scattering; Partial Dislocation; Basal Stacking Faults; Atomic Force Microscopy; Morphology; Crystal Quality; X-ray Rocking Curve [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/saff.png [video] => [the_novelty] =>

This innovation focuses on creating energy-efficient LEDs by improving its material preparation and structure. Results indicate that the use of AlN/GaN ML significantly reduces the defect on the surface of the nitride film. In addition, the increase of AlN/GaN pairs also enhances the crystal quality by 10-20% dues to the reduction of defect density. Hence, it can be concluded that the AlN/GaN ML plays a significant role in growing improved semi-polar thin films of LEDs.

[the_background] =>

The production of LED materials has always been challenging due to defect densities, high production costs and complex production processes. This study offers a convenient, cost-effective technique of preparing (growing) better materials by significantly enhancing the surface and structure of these materials. The production of better materials for LEDs will in turn make clean energy available and affordable to everyone.

[the_sdg_impact] =>

LEDs are widely used all over the world. However, the most common material used to LEDs proved challenging to prepare due to various factors from high defect rates to high manufacturing costs. In Malaysia, these factors are reinforced by the public’s perception of no cost-benefit to migrate from common fluorescent lightings to LED. The production of energy-efficient LEDs which are also cost effective will encourage consumers to opt for the obviously better choice. This will also inevitably generate public interest on sustainable energy usage contributing to achieving the UN’s seventh Sustainable Development Goal of creating affordable and clean energy.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S1369800118306966 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/photo-1495232714953-ef7f41577786-768x434-1.jpg [podcast] => [doi] => https://doi.org/10.1016/j.mssp.2018.06.014 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Embedded AlN/GaN multi-layer for enhanced crystal quality and surface morphology of semi-polar (11-22) GaN on m-plane sapphire [journal_title] => Materials Science in Semiconductor Processing [publisher] => Elsevier [year] => November 2018 [subject] => Physics ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [figures] => [research_highlights_video_thumbnail] => ) ) [206] => WP_Post Object ( [ID] => 20408 [post_author] => 1 [post_date] => 2020-10-22 15:55:27 [post_date_gmt] => 2020-10-22 15:55:27 [post_content] => [post_title] => Understanding Factors Affecting Tuna Fishing [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => understanding-factors-affecting-tuna-fishing [to_ping] => [pinged] => [post_modified] => 2021-07-03 13:32:36 [post_modified_gmt] => 2021-07-03 05:32:36 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20408 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KHAN, Alexander [researchers_position] => Department of Fisheries, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/34.jpg [researchers_profile] => https://www.researchgate.net/profile/Alexander_Khan3 [researchers_second_profile] => https://orcid.org/0000-0002-4275-1529 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Skipjack; skipjack tuna; eastern indonesia; fish aggregating devices; Eastern; tuna pole; pulau bacan; T. obesus; generalised additive models; sea surface temperature [graphic_abstract] => [video] => [the_novelty] =>

This study provided evidence that the oceanographic variable indeed influenced the skipjack tuna catches in eastern Indonesia. Among the oceanographic characteristics studied at the Fish Aggregating Devices (FADs) locations were sea surface temperature (SST), chlorophyll-a (chl-a), salinity (sal), wave height (wav), wind (win), and current (cur). Furthermore, the data collected also showed that the tuna pole-and-line fishing grounds heavily depend on the deployment of the FADs in eastern Indonesia. However, further studies on the relationships between the tuna fishing and other biotic and abiotic factors are suggested to strengthen the significance of this finding.

[the_background] =>

Catch-per-trip (CPT) or catch rate plays a highly significant role in fishery management. Literature mentioned that fishing operation relying strongly on the FADs deployment to minimize the operation cost as well as time spent locating populated tuna areas. Also, the local oceanographic characteristics affects the migration patterns of tuna schools, ultimately impacting the fishing outcome. This study aims to explore the relationships between the oceanographic variables at different FAD sites and the fishing outcome. The data collected could then be used to create a more sustainable fishery development.

[the_sdg_impact] =>

Based on a report published by the Food and Agriculture Organization of the United Nations, the total global marine catches reached 84.4 million tonnes in 2018. There was, in fact, a notable increase, over 6.7 million tonnes, in the marine catches in Indonesia alone. The UN has put forth intentions, in SDG 14: Life below water, to regulate the harvesting effectively, and end overfishing or destructive fishing practices by implementing research-based management plans. The results of this study could benefit the nation’s policymakers in restoring the fish stocks within a short timeframe and sustainably managing the tuna resources.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0165783619303261?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-34-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Alexander-Khan_1554997_1599545910.mp3 [doi] => https://doi.org/10.1016/j.fishres.2019.105471 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Oceanographic characteristics at fish aggregating device sites for tuna pole-and-line fishery in eastern Indonesia [journal_title] => Journal of Fisheries Research [publisher] => Elsevier [year] => May 2020 [subject] => Fisheries ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/rJae_hMKnaw [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-12.jpg ) ) [207] => WP_Post Object ( [ID] => 20403 [post_author] => 1 [post_date] => 2020-10-22 15:52:51 [post_date_gmt] => 2020-10-22 15:52:51 [post_content] => [post_title] => Understanding Dengue Transmission with Mathematics [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => understanding-dengue-transmission-with-mathematics [to_ping] => [pinged] => [post_modified] => 2021-07-16 11:31:57 [post_modified_gmt] => 2021-07-16 03:31:57 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20403 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ANGGRIANI, Nursanti [researchers_position] => Department of Mathematics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/6-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Nursanti_Anggriani [researchers_second_profile] => http://orcid.org/0000-0003-3609-6203 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Partial Rank Correlation Coefficient; transmission dynamics; endemic equilibrium; Stability; Basic Reproduction Ratio; antibody-dependent enhancement; secondary infection; Sensitivity analysis; antibody dependent enhancement; dynamics; equilibrium [graphic_abstract] => [video] => [the_novelty] =>

This research developed a novel multi-strain dengue mathematical model by considering the same strain reinfection probability. The outcomes were then used to understand its effects on the dengue transmission dynamics and predict potential outbreaks. A global sensitivity analysis was also conducted to determine the most influential parameters causing dengue transmission. Results suggested that same dengue strain reinfection does affect the dynamics of primary and secondary infections, and likely to be the factor causing increased secondary infection incidence. However, further validation of the model against real-world data is still needed.

[the_background] =>

Dengue is a mosquito-borne viral infection commonly prevalent in tropical and sub-tropical countries. Generally, it is known that there are four dengue strains, and those infected by certain strains of dengue become immune to that particular strain for life. Having said that, some studies showed reinfection by the same strain is possible. Although there are existing mathematical models developed to understand dengue transmission dynamics, none of which were built to investigate the effects of reinfection with the same strain on dengue transmission behavior. By developing a mathematical model that considers such factor, this research provides new insights into dengue infection rate and predict causes of potential dengue outbreaks.

[the_sdg_impact] =>

According to the WHO records, there are approximately 100 to 400 million dengue infections reported all over the world yearly. The drastic increase in the global incidence in recent decades threatens almost half of the world’s population. In an attempt to end dengue epidemics, this research aligns with UN SDG 3: Good health and well-being, to understand the factors influencing dengue transmission dynamics using mathematics. The findings could be expanded in the future to develop effective dengue prevention and vector control measures. Also, the proposed mathematical model could be further modified to analyze the transmission of other infectious diseases.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0096300318310695?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-6-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Nursanti-Anggriani_1092602_1597375234.mp3 [doi] => https://doi.org/10.1016/j.amc.2018.12.022 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The effect of reinfection with the same serotype on dengue transmission dynamics [journal_title] => Journal of Applied Mathematics and Computation [publisher] => Elsevier [year] => May 2019 [subject] => Mathematics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/_4qYZE2w5nA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Understanding-dengue-transmission-with-mathematics.mp4_snapshot_00.01_2021.07.16_11.30.23.png ) ) [208] => WP_Post Object ( [ID] => 20398 [post_author] => 1 [post_date] => 2020-10-22 15:50:33 [post_date_gmt] => 2020-10-22 15:50:33 [post_content] => [post_title] => Will Customers Buy from Vegetable Factories? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => will-customers-buy-from-vegetable-factories [to_ping] => [pinged] => [post_modified] => 2023-02-22 17:35:18 [post_modified_gmt] => 2023-02-22 09:35:18 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20398 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PERDANA, Tomy [researchers_position] => Department of Agro Socio-Economics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/31.jpg [researchers_profile] => https://www.researchgate.net/profile/Tomy_Perdana2 [researchers_second_profile] => https://orcid.org/0000-0003-0470-979X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Kaiser-Meyer-Olkin Statistics; weather condition; vegetable factory; factor analysis; supply chain; fresh product; emerging market; Measures of Sampling Adequacy; agriculture [graphic_abstract] => [video] => [the_novelty] =>

This research contributes to the literature in understanding the Indonesian consumer buying behavior towards the vegetable factory. The results identified 5 major factors influencing the customer purchasing decision – price, branding and packaging, product access, surface texture, and physical appearance of the vegetables. The data obtained from this research could be used for marketing purposes to promote the purchase of products from the vegetable factory. Apart from that, the practical implication of the research results serves as a guideline to develop vegetable factories in Indonesia, as well as other developing countries with strong agricultural dependency.

[the_background] =>

There is a growing demand for quality and healthy food supplies among consumers worldwide. Indonesia has also been experiencing a surge in national demand for fruits and vegetables to accommodate healthy lifestyle practice needs. The concept of vegetable factory promises to overcome the uncertainty surrounding conventional vegetable productions in terms of availability and quality. This research intends to align customer expectations and the practicality of having a vegetable factory. It also helps to gauge the readiness of customers to accept the concept of buying vegetable factory-processed products.

[the_sdg_impact] =>

Food security depends strongly on the agricultural strength of the nation to maintain the well-being of its people. The UN recognized the importance of going beyond hunger when they announced the targets for SDG 2: Zero hunger to ensure access safe, nutritious and sufficient food by all people throughout the year. This research sheds some light on how the agricultural industry, especially the fruit and vegetable production, could be upscaled via a vegetable factory. It also highlights the fact that vegetable factories are independent of the external factors, like weather or diseases, which could affect its production quantity and quality. Hence, providing a practical solution to overcome food insecurity in countries more prone to natural disasters.

[article_url] => http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=10087 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-31-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Tomy-Perdana_1525998_1599399154.mp3 [doi] => https://doi.org/10.18517/ijaseit.9.6.10087 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Customer Readiness in Emerging Market towards Vegetable Factories [journal_title] => Journal of Agriculture and Biological Sciences [publisher] => International Journal on Advance Science Engineering Information Technology [year] => September 2019 [subject] => Agriculture; Biological Sciences ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/bIlteFuKgY4 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Will-customers-buy-from-vegetable-factories.mp4_snapshot_00.01_2021.08.03_23.50.30.png [figures] => ) ) [209] => WP_Post Object ( [ID] => 20393 [post_author] => 1 [post_date] => 2020-10-22 15:47:21 [post_date_gmt] => 2020-10-22 15:47:21 [post_content] => [post_title] => Why Women with Breast Cancer Refuse Treatment? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => why-women-with-breast-cancer-refuse-treatment [to_ping] => [pinged] => [post_modified] => 2021-07-24 10:46:48 [post_modified_gmt] => 2021-07-24 02:46:48 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20393 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ISKANDARSYAH, Aulia [researchers_position] => Department of Clinical Psychology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/12.jpg [researchers_profile] => https://www.researchgate.net/profile/Aulia_Iskandarsyah [researchers_second_profile] => https://orcid.org/0000-0002-9526-6922 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => medical help; nonadherence; breast cancer; psychosocial factor; Hasan Sadikin Hospital; World Health Organization; breast cancer awareness [graphic_abstract] => [video] => [the_novelty] =>

Researchers have successfully constructed a theoretical model to describe the factors related to delayed medical help-seeking and non-compliance to treatment among Indonesian women with breast cancer. Eight major factors were identified based on this qualitative survey – lack of awareness and knowledge, cancer beliefs, treatment beliefs, financial constraints, emotional burden, severe treatment side effects, unable to communicate with healthcare providers, and unmet information needs. These psychosocial and culture-related barriers identified could be used to improve patient experience and acceptance towards acquiring continuous treatment for the disease. Some of the actionable initiatives suggested by the researchers are extensive financial support, disease and treatment awareness through media campaigns, as well as communication training for both patients and healthcare providers.

[the_background] =>

Data from past studies have shown that delayed medical help-seeking and inconsistent or refusal to receiving treatment leads to poor survival rate among breast cancer patients. To date, there are no general data available on the cancer care adherence rate among adult Indonesian women. Studies have also shown the impact of culture and belief system, illness awareness and misconceptions to be influencing factors of people’s behavior towards seeking medical attention. This study aims to explore the reasons for the delay in seeking medical help and nonadherence to treatment, specifically among Indonesian women with breast cancer. The findings serve as future intervention guidelines to increase medical attention-seeking and acceptance behavior in Indonesia.

[the_sdg_impact] =>

Reports have shown that patients with cancer located only at the breast has a 99% 5-year survival rate, but if cancer has spread to distant body parts, the 5-year survival rate reduces drastically to only 27%. Hence, women with breast cancer should get diagnosed and treated as early as possible to improve their survival rate. The outcome of this research could be used to encourage breast cancer patients to seek treatment better, reducing the chances of premature mortality rate not only in Indonesia, potentially in other countries too. This fits the aim of the UN SDG3: Good health and well-being.

[article_url] => https://psycnet.apa.org/record/2013-01793-001 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-12-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Aulia-Iskandarsyah_1093355_1597379023.mp3 [doi] => https://doi.org/10.1037/a0031060 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Psychosocial and cultural reasons for delay in seeking help and nonadherence to treatment in Indonesian women with breast cancer: A qualitative study [journal_title] => Journal of Health Psychology [publisher] => American Psychological Association [year] => January 2013 [subject] => Clinical Psychology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [210] => WP_Post Object ( [ID] => 20388 [post_author] => 1 [post_date] => 2020-10-22 15:44:38 [post_date_gmt] => 2020-10-22 15:44:38 [post_content] => [post_title] => Whole-genome Sequencing (WGS) for TB Strain [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => whole-genome-sequencing-wgs-for-tb-strain [to_ping] => [pinged] => [post_modified] => 2021-08-05 12:56:59 [post_modified_gmt] => 2021-08-05 04:56:59 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20388 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHAIDIR, Lidya [researchers_position] => Department of Medicine, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/47.jpg [researchers_profile] => https://www.researchgate.net/profile/Lidya_Chaidir [researchers_second_profile] => https://orcid.org/0000-0001-5661-4050 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => drug susceptibility testing; tuberculosis; genome sequencing; m. tuberculosis; Whole-genome sequencing; Drug resistance; Resistance mutations; mycobacterium tuberculosis; indonesia; phenotypic dst [graphic_abstract] => [video] => [the_novelty] =>

This pilot study used whole-genome sequencing (WGS) to screen for drug resistance in different Mycobacterium tuberculosis strains in the Indonesia population. The outcome of this study offers WGS as a rapid, affordable and comprehensive diagnostic tool that is also portable, improving the chances of being diagnosed and be given more appropriate treatment. It was also observed that drug-resistant TB strains are more common among those with Indo-Oceanic lineage compared to those with Euro-American and East-Asian lineages. That being said, those of East-Asian lineages are more susceptible to host multiple mutated strains. Therefore, WGS is a promising computational method used to understand the influence of genetic data and mutation consequences of all M. tuberculosis strains with drug resistance. It serves as a good starting point to improve clinical management and TB control efforts in developing countries like Indonesia.

[the_background] =>

There is a huge gap between multidrug-resistant TB incidence and treatment in Indonesia, leading to delayed detection and inappropriate treatment administration. Existing conventional methods, such as culture-based drug susceptibility testing (DST) and molecular-based DST, are tedious, time-consuming, inconsistent, and has incomplete sensitivity to determine multidrug-resistant TB. WGS is gradually gaining reputation as a reliable tool to predict drug resistance of different Mycobacterium tuberculosis strains, and it is yet to be explored in high-endemic settings. This study provides the first evidential data of M. tuberculosis strains resistant to first- and second-line TB drugs in Indonesia predicted using WGS. It also examines the effectiveness of phenotypic DST when cross-referenced with WGS data of different M. tuberculosis strains.

[the_sdg_impact] =>

According to a 2017 report from the World Health Organization (WHO), there is a constant increase of anti-TB drug resistance cases globally, despite increased testing. It was also reported that close to 230 000 people died of TB in that year, mostly in India and China, due to ineffective TB care/treatment. To address the global multidrug-resistant TB crisis, this study contributes evidence to scale up rapid testing and detection procedures by introducing WGS as a reliable diagnostic tool. Proper diagnosis improves effectiveness of treatment, which aligns with the visions of UN SDG 3: Good health and well-being, to end the epidemics of tuberculosis by 2030.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S2213716518301656?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-47-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Lidya-Chaidir_1683492_1600152245.mp3 [doi] => https://doi.org/10.1016/j.jgar.2018.08.018 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Use of whole-genome sequencing to predict Mycobacterium tuberculosis drug resistance in Indonesia [journal_title] => Journal of Global Antimicrobia Resistance [publisher] => Elsevier [year] => March 2019 [subject] => Medical; Medicine ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/5d2vxo8mH_w [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Whole-genome-sequencing-WGS-for-anti-TB-drug-resistance-diagnosis.mp4_snapshot_00.02_2021.07.16_12.04.27.png [figures] => ) ) [211] => WP_Post Object ( [ID] => 20382 [post_author] => 1 [post_date] => 2020-10-22 15:33:58 [post_date_gmt] => 2020-10-22 15:33:58 [post_content] => [post_title] => Using Papaya Waste to Produce ß-glucan as Scavenger of Free Radical [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => using-papaya-waste-to-produce-b-glucan-as-scavenger-of-free-radical [to_ping] => [pinged] => [post_modified] => 2021-07-03 13:56:10 [post_modified_gmt] => 2021-07-03 05:56:10 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20382 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LARA UTAMA, Gemilang [researchers_position] => Department of Food Industrial Technology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/36.jpg [researchers_profile] => https://www.researchgate.net/profile/Gemilang_Lara_Utama [researchers_second_profile] => http://orcid.org/0000-0003-3382-2855 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => S. cerevisiae; papaya waste; antioxidant activity; banana waste; napa cabbage waste; glucan mass; ß-glucan; fermentation medium; fruit waste [graphic_abstract] => [video] => [the_novelty] =>

In an attempt to understand the agricultural waste disposal landscape of Indonesia, this study showed that the best substrate in producing ß-glucan from Saccharomyces cereviseae was papaya waste, compared to the banana waste and napa cabbage waste. The ß-glucan yielded from Saccharomyces cereviseae that be grown at the papaya waste reported to display radical scavenging activity of 20.71% and a globular diameter of 533μm. The experiment was conducted by growing S. cerevisieae on the three different organic wastes, followed by the extraction of ß-glucan from the S. cerevisieae cell walls. The positive results proved that papaya waste is a potential substrate for producing ß-glucan, in which its feasibility in various applications as a scavenger of free-radical can be further explored.

[the_background] =>

It is a norm for a large-population country like Indonesia to produce a significant tonnage of organic waste daily. Besides increasing the cost of waste disposal and causing odor, organic waste also gives rise to CO2 and CH4 when under anaerobic conditions. These gases will deplete the ozone layer, which, in turn, allows the penetration of ultraviolet rays to yield more free radicals. Hence, to overcome those issues concurrently, organic wastes such as vegetable and fruit waste can be used as a substrate to produce free radical scavenger. The local Central Bureau of Statistics had reported that the three highest amounts of vegetable and fruit wastes comprised banana waste, papaya waste, and napa cabbage waste. That was the reason for these wastes to be used in this study. These high carbohydrate substrates, which are abundant in Indonesia, are good candidates for such an effort even though they are yet to be widely studied or used globally. The findings showed that ß-glucan could be produced using these substrates. β–glucan is a soluble fiber found in the cell walls of cereals, bacteria, and fungi. Nevertheless, other than improving the yield of ß-glucan, the biological potential of ß-glucan as an antioxidant should be determined.

[the_sdg_impact] =>

In Indonesia, the organic waste amounts up to 60% of total waste. If there is no effort taken to deal with this scenario, it is very likely to cause severe pollutions. Improving the environment brings about a chain effect that involves the realization of multiple UN’s Sustainable Development Goals (SDG). Since the UN aims to reduce the number of deaths and illnesses from hazardous chemicals and air, water and soil pollution and contamination by 2030, this study contributes to the realization of Goal 3: Good Health & Well-Being.

[article_url] => https://acta.mendelu.cz/68/1/0119/ [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-36-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Gemilang-Lara-Utama_1596140_1599713412.mp3 [doi] => https://doi.org/10.11118/actaun202068010119 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The Utilization of Vegetable and Fruit Wastes for Saccharomyces cerevisieae Cell Wall Based β-Glucan Production with Antioxidant Activity [journal_title] => Acta Universitatis Agriculturae et Silviculturae Mendelianae [publisher] => Acta Universitatis Agriculturae et Silviculturae Mendelianae [year] => February 2020 [subject] => Food Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/e3GqlPJznRA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-9.jpg ) ) [212] => WP_Post Object ( [ID] => 20374 [post_author] => 1 [post_date] => 2020-10-22 15:30:11 [post_date_gmt] => 2020-10-22 15:30:11 [post_content] => [post_title] => Treating Recurrent Aphthous Stomatitis Using α-Mangostin [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => treating-recurrent-aphthous-stomatitis-using-a-mangostin [to_ping] => [pinged] => [post_modified] => 2021-05-12 10:39:54 [post_modified_gmt] => 2021-05-12 02:39:54 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20374 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WATHONI, Nasrul [researchers_position] => Department of Pharmaceutics and Pharmaceutical Technology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/42.jpg [researchers_profile] => https://www.researchgate.net/profile/Nasrul_Wathoni [researchers_second_profile] => http://orcid.org/0000-0002-5985-6909 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => pure α m.; alginate; chalg hf; chalg/α m hf; X-ray diffraction; scanning electron microscopy; tensile strength; differential scanning calorimetry; Recurrent aphthous stomatitis; chitosan; Hydrogel film [graphic_abstract] => [video] => [the_novelty] =>

This study has successfully developed α-mangostin hydrogel film based chitosan–alginate (ChAlg/α-M HF) to be used in the therapy of recurrent aphthous stomatitis (RAS). The samples were prepared using the solvent evaporation method. Other than physicochemical characterizations, computational, in vitro and mucoadhesive studies were also carried out to determine the potential of ChAlg/α-M HF as a carrier for α-mangostin (α-M). Based on the promising results, the study should be expanded to animal models in the future to determine its feasibility and efficiency.

[the_background] =>

RAS is the most common ulcerative disease in the oral mucosa (i.e., the mucous membrane lining the inside of the mouth) in humans. To date, there is no effective RAS therapy yet. The use of existing drugs in RAS targets to accelerate the regeneration of tissue cells. Antiseptic drugs, local anesthetics, and corticosteroids are often used for RAS therapy, but they are also known to cause harmful side effects if being used too frequently and over a long period. Meanwhile, α-mangostin (α-M) is the main compound of mangosteen peel, and it has been known as an agent for oral cavity therapy. However, α-M is difficult to be delivered directly to the site because of its insolubility in water. Thus, a carrier is needed to deliver α-M, and this study has aimed to develop a potential carrier to deliver α-M for RAS therapy.

[the_sdg_impact] =>

RAS is one of the most common oral disorders. Since there is no effective therapy for RAS yet, developing a cure for it would be a breakthrough. The outcome of this study has a high potential in synthesizing an effective cure for RAS. This would minimize the exposure to the harmful side effects caused by the drugs being used in RAS therapy. As the UN aims to support the research and development of medicines, this study contributes to the realization of Goal 3: Good Health and Well-being of Sustainable Development Goals.

[article_url] => https://www.mdpi.com/2076-3417/9/23/5235 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/mangosteen.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Nasrul-Wathoni_1649117_1599988238.mp3 [doi] => https://doi.org/10.3390/app9235235 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis [journal_title] => Journal of Applied Science [publisher] => MDPI [year] => December 2019 [subject] => Pharmaceutics; Pharmaceutical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/EoFDMGQQEjQ [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/44-w-subs-music.mp4_snapshot_00.01_2021.05.12_10.38.24.jpg ) ) [213] => WP_Post Object ( [ID] => 20369 [post_author] => 1 [post_date] => 2020-10-22 15:27:38 [post_date_gmt] => 2020-10-22 15:27:38 [post_content] => [post_title] => The Role of MicroRNAs in Premature Senescence [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => the-role-of-micrornas-in-premature-senescence-x-fp [to_ping] => [pinged] => [post_modified] => 2021-07-19 13:26:37 [post_modified_gmt] => 2021-07-19 05:26:37 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20369 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WONG, Pooi-Fong [researchers_position] => University of Malaya | UM · Department of Pharmacology [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/download-7.jpg [researchers_profile] => https://www.researchgate.net/profile/Pooi-Fong_Wong [researchers_second_profile] => https://orcid.org/0000-0002-6705-2521 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => MicroRNA-107; Mammalian Target of Rapamycin; Rapamycin; Cellular Senescence; Human Endothelial Cell Rapamycin; MTOR Complex 1; Phosphatase and Tensin Homolog; Low Dose Rapamycin [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/wpf3.jpg [video] => [the_novelty] =>

This study investigates the role of microRNAs in premature deterioration of endothelial cells. It was proven in this study that the downregulation of the MTORC1 pathway can delay the onset of cell deterioration. The specific miRNA which is involved in the inhibition of this pathway is identified as miRNA-107. The increase in miRNA-107 expression leads to the rise of MTORC1 activities which prompts cell senescence. On the other hand, the decrease of miRNA-107 via long-term low dose rapamycin delays senescence. Thus, through further applied and translational studies, this discover could benefit global aging population by reducing risks of aging-related diseases.

[the_background] =>

By understanding the mechanism of endothelial senescence, age-related vascular diseases such as cardiovascular diseases and atherosclerosis can also be prevented. The discovery of this study can also help in developing RNA-based therapies besides the identification of new targets in disease intervention. This is especially beneficial as age-related diseases are on the rise alongside the increasing numbers of aging population all over the world due to medical and technological advancement.

[the_sdg_impact] =>

Cellular senescence can be defined as the biological aging of the cell where the cell’s functionality gradually deteriorates. Cellular senescence affects the ability of cells to divide and proliferate. Numerous studies have been done to investigate the process of aging. At the cellular level, aging can be prevented by the inhibition of MTORC1 pathway. The mechanism of this process involves microRNA which regulates cell functions. In line with UN’s third Sustainable Development Goal, an in-depth comprehension of this process can contribute in innovative strategies that can counter premature senescence aiding the aging population in preserving not just good health but also good well-being.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S1357272518301286?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/science.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Wong-PF-Audio-PLS_1071567_1597287759.mp3 [doi] => https://doi.org/10.1016/j.biocel.2018.05.016 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107 [journal_title] => International Journal of Biochemistry & Cell Biology [publisher] => Elsevier [year] => August 201 [subject] => Biochemistry and Cell Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/V1DOnLzVDeM [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-40.jpg ) ) [214] => WP_Post Object ( [ID] => 20364 [post_author] => 1 [post_date] => 2020-10-22 15:23:05 [post_date_gmt] => 2020-10-22 15:23:05 [post_content] => [post_title] => Synthetic Glycans – A Novel Anticancer Agent Against Glioblastoma [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => synthetic-glycans-a-novel-anticancer-agent-against-glioblastoma [to_ping] => [pinged] => [post_modified] => 2021-09-20 15:48:59 [post_modified_gmt] => 2021-09-20 07:48:59 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20364 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => FARIED, Ahmad [researchers_position] => Department of Neurosurgery, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/1-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Ahmad_Faried [researchers_second_profile] => https://orcid.org/0000-0003-2967-8125 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => poly (adenosine diphosphate-ribose) polymerase; phosphatidylinositol 3-kinase; autophagic; glioblastoma cell; apoptosis; autophagy; mammalian target of rapamycin; synthetic glycan; glioblastoma; cell death [graphic_abstract] => [video] => [the_novelty] =>

This study demonstrated synthetic glycans (sugar cholestanols) as promising novel anticancer agents against glioblastoma cells in both animal and human cancer cell models. For the first time, it was evidenced that these synthetic glycans could trigger not only cellular apoptosis, but also the autophagic (self-consuming) mechanism of the naturally death-resistant glioblastoma cells. This programmed cell death induced is followed by a series of continuous activation and suppression of several molecular expressions. When treated with the sugar cholestanols, there were increased expression of p53 in ser46, downregulated activation of glutamate-AMPA receptors–Akt/mTOR pathway, and decreased expression of Rho GTPases (RhoA and RhoC), all of which contributed to glioblastoma cell apoptosis and autophagy. Therefore, this synthetic glycans proved its potential as a reliable anticancer agent against this malignant brain cancer. However, further clinical experiments are still needed.

[the_background] =>

Glioblastoma is the most aggressive form of cancer of the central nervous system, mainly attacking the brain. The poor survival rate and ineffectiveness of existing surgical and radiation therapies urge neuroscience experts to improve the treatment for this lethal brain cancer. Previous studies on chemically synthesized glycans have shown promising anticancer properties in animal and human cancer cells of the digestive system. This study aimed to further explore the clinical potential of synthetic glycans to induce programmed cell death in human glioblastoma cells and mouse models. By understanding the biological mechanism causing the termination of glioblastoma cell growth, novel strategies and anticancer drugs could be designed to improve the prognosis.

[the_sdg_impact] =>

It is part of the vision of the United Nations, stated explicitly under its SDG 3: Good Health and Well-being, to reduce premature mortality rate and support the development of drug discovery against diseases like cancer. Since the brain and other nervous system cancer is the 10th leading cause of fatality among men and women worldwide, new strategies and treatments must be developed to increase survival rates. As glycotherapy continues to inspire numerous advancements in cancer therapy, this study revealed the potential role of synthetic glycans in the fight against glioblastoma.

[article_url] => https://thejns.org/view/journals/j-neurosurg/120/6/article-p1298.xml [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/un1-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Ahmad-Faried_1091532_1597369518.mp3 [doi] => https://doi.org/10.35841/biomedicalresearch.30-19-257 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Enhanced expression of proapoptotic and autophagic proteins involved in the cell death of glioblastoma induced by synthetic glycans [journal_title] => Journal of Neurosurgery [publisher] => JNS [year] => June 2014 [subject] => Neurosurgery ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/V4XJkVcF_Tk [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Synthetic-Glycans-–-A-Novel-Anticancer-Agent-Against-Glioblastoma.mp4_snapshot_00.01_2021.07.16_11.58.17.png [figures] => ) ) [215] => WP_Post Object ( [ID] => 20361 [post_author] => 1 [post_date] => 2020-10-22 15:20:10 [post_date_gmt] => 2020-10-22 15:20:10 [post_content] => [post_title] => Role of Melatonin in Treating Rheumatoid Arthritis [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => role-of-melatonin-in-treating-rheumatoid-arthritis [to_ping] => [pinged] => [post_modified] => 2021-07-19 10:48:39 [post_modified_gmt] => 2021-07-19 02:48:39 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20361 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TANG, Chih‐Hsin (湯智昕) [researchers_position] => Department of Pharmacology, School of Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/jishin.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/38993039-Chih-Hsin-Tang [researchers_second_profile] => https://orcid.org/0000-0002-7113-8352 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Tumor Necrosis Factor‐α;; TNF‐α; Arthritis; miR‐3150a‐3p; Rheumatoid Arthritis; Collagen‐induced Arthritis; IL‐1β; PI3K; Melatonin; T Helper [graphic_abstract] => [video] => https://www.youtube.com/embed/J1RpmQy9cyc [the_novelty] =>

This research provided evidence that melatonin improves rheumatoid arthritis (RA) conditions when tested on the CIA mouse model. Depending on the dose administered, melatonin was able to inhibit cytokines, specifically tumor necrosis factor- α (TNF-α) and interleukin (IL)-1β expression, which causes inflammation. This attributes to the melatonin’s ability to downregulate three different signaling pathways, mainly, PI3K/AKT, ERK, and NF-κB. Through computational prediction software, this study identified that melatonin was also capable of upregulating the miR-3150s-3p expression. The increased expression of this microRNA led to the reduction of TNF-α and IL-1β production, eventually portraying anti-inflammatory properties in RA-induced CIA mice.

[the_background] =>

Rheumatoid arthritis (RA) is a common inflammatory joint disorder caused by an auto-immune condition that leads to joint destruction and disability if left untreated. The existing RA drugs in the market, though target cytokines responsible for inflammation and progression of RA, are still not beneficial to some RA patients, while many eventually experience ineffectiveness in treatment over time. A hormone called melatonin exhibited promising traits in suppressing inflammatory biological pathways, intriguing many researchers to explore its properties as potential RA treatment further. This study was able to justify the positive effects of melatonin in inhibiting cartilage degradation and bone erosion at a molecular level. Apart from that, this study also established a positive connection between a specific microRNA expression induced by melatonin and the signaling pathways causing RA progression. The outcome of this study proved that melatonin has the potential to be used as adjuvant therapy for RA treatment. However, further clinical investigations are required.

[the_sdg_impact] =>

According to the Global Burden of Disease, Injuries, and Risk Factors (GBD) Study, in 2017, approximately 20 million patients were said to be living with rheumatoid arthritis (RA), with an annual diagnosis of over a million new cases. WHO categorizes rheumatoid arthritis (RA) as a chronic musculoskeletal disease, which could lead to immense pain, deformity, and disability. Alarmingly, if left untreated, almost 50% of the RA patients are unable to maintain employment. In alignment with Goal 3 of the UN’s Sustainable Development Goals, Good health and well-being, this study provides an opportunity to improve the healthcare services by providing adequate medical treatment for those suffering from RA. Also, this study could potentially reduce the prevalence of disability and discomfort caused by RA, thus promoting a better quality of life and mental well-being.

[article_url] => https://onlinelibrary.wiley.com/doi/abs/10.1111/jpi.12560 [main_image] => [podcast] => [doi] => https://doi.org/10.1111/jpi.12560 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis [journal_title] => Journal of Pineal Research [publisher] => Wiley [year] => January 2019 [subject] => Medical; Pharmacology ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/Role-of-Melatonin-in-Treating-Rheumatoid-Arthritis.mp4_snapshot_00.03_2021.05.11_10.23.36.jpg ) ) [216] => WP_Post Object ( [ID] => 20357 [post_author] => 1 [post_date] => 2020-10-22 15:17:35 [post_date_gmt] => 2020-10-22 15:17:35 [post_content] => [post_title] => Role of HLA-B27 Activation in Spinal Deformation [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => role-of-hla-b27-activation-in-spinal-deformation [to_ping] => [pinged] => [post_modified] => 2022-06-24 09:57:16 [post_modified_gmt] => 2022-06-24 01:57:16 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20357 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Shih-Chieh (洪士杰) [researchers_position] => Integrative Stem Cell Center, Department of Orthopedics, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/sadx.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Shih-Chieh-Hung-39973108 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Spliced X-box–binding Protein 1; RARBtissue-nonspecific Alkaline Phosphatase; Spondylitis; Bone-specific TNAP; Human Leukocyte Antigen-B27; Ankylosing Spondylitis; Mesenchymal Stem Cells; Bone Marrow; as msc [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/ga2-1024x377-1.png [video] => https://www.youtube.com/embed/HwW7rcy4mPQ [the_novelty] =>

This research reveals that human leukocyte antigen-B27 (HLA-B27) misfolding activates pathways such as p-IRE1/sXBP1/RARB/TNAP within the enthesis (ligament and bone connective tissue) that lead to the development of syndesmophyte (bone) formation in ankylosing spondylitis mesenchymal stem cells (AS MSCs). Targeting these pathways helps identify strategies to block unfavorable bone formation. The dual effect of pamidronate, which blocks mineralization and inhibits bony placement, could potentially be used in drug therapies to prevent spinal fusion and osteoporosis. A novel animal-based model that mimics the bony placement developed in this research is suggested as a more suitable platform for future drug testing. Furthermore, it is proven that serum BAP levels are potential biomarkers for the identification of high-risk AS patients predisposed to radiography progression, and TNAP inhibitors could be utilized in bony outgrowth prevention.

[the_background] =>

Ankylosing spondylitis (AS) is an inflammatory disease that causes the fusion of small bones in the spine resulting in a forward-hunched posture. The association of the development of AS ties closely with HLA-B27. Treatment options available currently treat inflammation but do not entirely stop unfavorable bone formation. Factors such as minimal understanding of stromal activation, limited access to drug screening, and unavailability of biomarkers to identify high-risk patients are reasons for the limited treatment options available in the market. Mesenchymal stem cells (MSCs) isolated from the connective tissues of ligaments and bones of AS patients reveal a pathway relevant to the syndesmophyte growth in AS patients, which could be explored to determine drug treatment options. In a clinical setting, by working on the serum from AS patients, this study explores the possibility of utilizing serum TNAP levels as a biomarker to identify high-risk patients. Findings of the research show HLA-B27 as a mediator of AS, opening up new strategies to further develop novel and effective AS therapy.

[the_sdg_impact] =>

According to data published in BMC Rheumatology, the prevalence rate for AS doubled from the year 2006 to 2016. Its prevalence is higher among men compared to women and is said to show signs and symptoms during early adulthood. The progression of this illness clearly poses a threat to presume a normal lifestyle, especially concerning employment and mobility. The establishment of the role of HLA-B27 associated with ankylosing spondylitis aligns with Goal 3: Good health and well-being of Sustainable Development Goals. By studying the genome-wide association, more effective treatments and prevention methods could be developed through bioengineering, ultimately improving the quality of life of those suffering from AS.

[article_url] => https://www.jci.org/articles/view/125212 [main_image] => [podcast] => [doi] => https://doi.org/10.1038/s41467-019-10197-x [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => HLA-B27–mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis [journal_title] => Journal of Clinical Investigation [publisher] => JCI [year] => November 2019 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-24.jpg [figures] => ) ) [217] => WP_Post Object ( [ID] => 20351 [post_author] => 1 [post_date] => 2020-10-22 15:13:50 [post_date_gmt] => 2020-10-22 15:13:50 [post_content] => [post_title] => Role of Glutathione Peroxidase 8 (GPx8) against Colon Ulcers (Colitis) [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => role-of-glutathione-peroxidase-8-gpx8-against-colon-ulcers-colitis [to_ping] => [pinged] => [post_modified] => 2021-07-19 10:52:30 [post_modified_gmt] => 2021-07-19 02:52:30 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20351 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LEE, Wen-Hwa (李文華) [researchers_position] => Drug Development Center, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/lee.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Wen-Hwa-Lee-38659564 [researchers_second_profile] => https://orcid.org/0000-0002-4098-5225 ) [researchers_info_2] => Array ( [researchers_name_2] => HSU, Jye-Lin (徐婕琳) [researchers_position_2] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2020/10/display-photo2.png [researchers_profile_2] => https://www.researchgate.net/scientific-contributions/Jye-Lin-Hsu-2167297084 [researchers_second_profile_2] => https://orcid.org/0000-0001-6687-4083 ) [original_article_reference] => [research_footprints] => Macrophages; Glutathione Peroxidase 8; Inflammasome; Colitis; Glutathione Peroxidase; Non-canonical Inflammasome; Bone Marrow-derived Macrophages; E. Colicaspase-4; Canonical Inflammasome; Dextran Sulfate Sodium [graphic_abstract] => [video] => https://www.youtube.com/embed/0cDvGcVRjWY [the_novelty] =>

This research provided evidence that glutathione peroxidase 8 (GPx8) protects the colon lining from inflammation by inhibiting caspase-4/11 activity in mice. The disulfide bonding of GPx8 onto the caspase-4/11 restrains the non-canonical inflammasome pathway during increased reactive oxygen species (ROS) level in cells. In the absence of GPx8, colitis and endotoxic shock were observed along with a mass depletion of the gut microbiome as a result of caspase 4/11 over-expression. By treating the GPx8-deficient mice with a strong antioxidant, N-acetylcysteine (NAC), or a caspase-4 inhibitor, VX-765, the progression of colitis was suppressed. Since samples from patients with colitis showed a decreased level of GPx8 in their macrophages and increased expression of caspase-4, the results of this research could be used to develop an effective drug to treat colitis.

[the_background] =>

Colitis is a type of inflammatory bowel disease (IBD) that causes inflammation in the colon lining. It is a result of an excessive expression of caspase-4/11 by the host in which the primary target should be against bacterial infection. With that being said, the association of caspase-4/11 activation in the progression of IBD remained unknown. This study showed the correlation between GPx8, an antioxidant gene, and the caspase-4/11 signaling pathway in response to ROS that contributed to the development of the disease. Though NAC has shown positive results in inhibiting ROS generation, the complexity of ROS functional mechanisms makes it an impossible choice to combat IBD. However, the establishment of the link between GPx8 and caspase-4/11 promises a therapeutic breakthrough that solely targets the non-canonical inflammasome pathway in patients with colitis.

[the_sdg_impact] =>

According to the Crohn’s & Colitis Foundation, an estimated 1.6 to 3.1 million Americans suffer from IBD, a disease commonly found in western and developed nations. With such concerning prevalence rate, the actual cause or even cure to this disease is yet to be found. The effects, however, threaten the quality of life as a whole, including reduced ability to work, social stigmatization, difficulty with physical intimacy, etc. In line with Goal 3 of Sustainable Development Goal, Good health and well-being, this research provides an insight into the molecular cause of colitis and a potential treatment targeting the biological pathways involved in the development of the disease. Thus, reducing the chances of premature mortality and promoting mental health and well-being for those suffering from this disease.

[article_url] => https://www.embopress.org/doi/full/10.15252/emmm.201809386 [main_image] => [podcast] => [doi] => https://doi.org/10.15252/emmm.201809386 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis [journal_title] => Embo Molecular Medicine [publisher] => Embo Press [year] => January 2020 [subject] => Medical; Biomedical Science; Drug Development ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-32.jpg ) ) [218] => WP_Post Object ( [ID] => 20347 [post_author] => 1 [post_date] => 2020-10-22 15:10:31 [post_date_gmt] => 2020-10-22 15:10:31 [post_content] => [post_title] => Role of Fibroblast in the Growth of Uterine Cancer Cells [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => role-of-fibroblast-in-the-growth-of-uterine-cancer-cells [to_ping] => [pinged] => [post_modified] => 2022-07-08 10:45:08 [post_modified_gmt] => 2022-07-08 02:45:08 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20347 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHUNG, Ivy [researchers_position] => University of Malaya | UM · Department of Pharmacology [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/09/ivy-chung.png [researchers_profile] => https://www.researchgate.net/profile/Ivy_Chung2 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Vascular Endothelial Growth Factor; Fetal Bovine serum; Fibroblast Cell; MAPK; Cancer-associated Fibroblasts; Cell Proliferation; Cell line; Endometrial Cancer; Endometrial Hyperplasia [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/ivy.png [video] => https://www.youtube.com/embed/mezfP7eP5YY [the_novelty] =>

This is a preliminary study to prove that cancer-associated fibroblasts (CAFs) increase the growth of endometrial cancer cells. Unlike normal fibroblasts, it is identified that PI3K/Akt and MAPK/Erk pathways in endometrial cancer cells are significantly activated in the presence of CAFs-treated cells. The activation of communication pathways between cancerous cells indirectly encouraging the growth of these cancerous cells. Results show that the inhibition of these CAFs disrupt cell growth and may eventually restrain the spread of cancerous cells. This benefits scientists and clinicians worldwide in improving therapies not only for uterine cancer but also for other types of cancer.

[the_background] =>

The focus of drug development in cancer treatment has always been on the eradication of cancer cells in the body. However, little research is being done on preventing the spread of cancer cells. The discovery of the role of fibroblasts in the survival and growth of endometrial cancer cells enables the development of drugs that inhibits the metastasis of cancer cells. Unlike current available treatment, drugs can be developed to target only malignant cells while preserving normal tissues and the womb indirectly increasing survival rate.

[the_sdg_impact] =>

Endometrial cancer has been on the rise due to various factors such as obesity and unopposed hormone usage. Being the fourth most commonly diagnosed cancer among women globally, the treatment for early detection is usually surgery. Current treatments are focused on reducing the chances of surgery and preserving the womb. The understanding of the interaction and cellular processes between cancer cells is important as it can guide new development of therapy which minimizes the negative effects of surgery and existing treatments. In line with UN’s third Sustainable Development Goal, this finding could drastically improve the quality of life for many patients as the possibility of non-invasive treatments not only aids in the cure of the disease but also maintains their general well-being.

[article_url] => https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068923 [main_image] => [podcast] => [doi] => https://doi.org/10.1371/journal.pone.0068923 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Cancer-Associated Fibroblasts Promote Proliferation of Endometrial Cancer Cells [journal_title] => PLOS ONE [publisher] => Public Library of Science [year] => July 2013 [subject] => Biochemistry and Cell Biology; Oncology and Carcinogenesis ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-42.jpg [figures] => ) ) [219] => WP_Post Object ( [ID] => 20343 [post_author] => 1 [post_date] => 2020-10-22 15:06:40 [post_date_gmt] => 2020-10-22 15:06:40 [post_content] => [post_title] => Role of Dental Pulp Mesenchymal Stem Cells in Bone Formation and Tumor Development [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => role-of-dental-pulp-mesenchymal-stem-cells-in-bone-formation-and-tumor-development [to_ping] => [pinged] => [post_modified] => 2022-06-24 09:57:56 [post_modified_gmt] => 2022-06-24 01:57:56 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20343 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Shih-Chieh (洪士杰) [researchers_position] => Integrative Stem Cell Center, Department of Orthopedics, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/sadx.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/Shih-Chieh-Hung-39973108 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Pten Expression; dp msc; Polymerase Chain Reaction; Phosphatase and Tensin Homolog; Reverse Transcription; DP-MSC; Lineage Commitment; Mesenchymal Stem Cells; DNA (cytosine-5) Methyltransferase; Stem Cell; bm msc; BM-MSC [graphic_abstract] => [video] => https://www.youtube.com/embed/rHjG8yykcr0 [the_novelty] =>

This research provided the first evidence of the role of phosphatase and tensin homolog (PTEN) expression in lineage commitment and tumor development in human adult stem cells. It revealed that the regulation of G9a/DNMT3B/PTEN/AKT pathways contributed to the reprogramming of human adult stem cell differentiation potential. A higher PTEN expression in dental pulp mesenchymal stem cells (DP-MSCs) than in bone marrow mesenchymal stem cells (BM-MSCs) potentially improved bone formation, and reduced fats and tumor formation. This is a result of IGF-2-mediated signals inhibition, which in turn modulates insulin signaling and AKT activation. Besides, this study also proved that by reducing the expression of DNA-methyltransferase 3 beta (DNMT3B), BM-MSCs could be converted into DP-MSCs. Thus, improving the chances of clinical application when it comes to dental regeneration.

[the_background] =>

Adult stem cells regulated by genetic and microenvironment factors are cellular sources of cancer. Human mesenchymal stem cells (MSCs), though isolated from different tissues, like bone marrow (BM-MSCs) and dental pulp (DP-MSCs), are known to exhibit cellular and molecular similarities. Though there has been proof from recent studies that these cells do have varied differentiation and tumor formation potentials, the system that regulates these processes remain unclear. PTEN, formerly known as a tumor suppressor and recently claimed to drive bone malignancy, modulates cell functions, including cell differentiation and proliferation. However, its roles in regulating the lineage commitment and tumor formation in DP-MSCs and BM-MSCs are largely unknown. This research was able to establish novel functional signatures between both DP-MSCs and BM-MSCs by studying the fat formation mechanism and tumor development potential in DP-MSCs. By providing an in-depth understanding of such biological behaviors, this research proves to be of great value in exploring regenerative medicine, dentistry, tissue engineering, and future therapeutic stem cell technology development.

[the_sdg_impact] =>

With so many controversies surrounding the usage of embryonic stem cells in the development of regenerative medicine, research on adult stem cells could be the healthcare future that we seek. Nevertheless, mesenchymal stem cell (MSC) extraction of the dental pulp is less invasive than that of bone marrow. The role of DP-MSCs in suppressing tumor growth that has been proven in this research aligns perfectly with the objectives of Goal 3: Good health and well-being of Sustainable Development Goal. By providing the evidence and insight into the biological mechanisms involved in reducing the potential of bone malignancy, this research could potentially reduce the premature mortality rate among cancer patients by advancing stem cell therapy. Therefore, paving a pathway to revolutionize regenerative medicine and improve the quality of life for those seeking treatment.

[article_url] => https://www.nature.com/articles/s41467-019-10197-x [main_image] => [podcast] => [doi] => https://doi.org/10.1038/s41467-019-10197-x [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Methylation and PTEN Activation in Dental Pulp Mesenchymal Stem Cells Promotes Osteogenesis and Reduces Oncogenesis [journal_title] => Nature Communications [publisher] => Springer Nature [year] => May 2019 [subject] => Medical; Orthopedics ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-30.jpg [figures] => ) ) [220] => WP_Post Object ( [ID] => 20338 [post_author] => 1 [post_date] => 2020-10-22 15:04:19 [post_date_gmt] => 2020-10-22 15:04:19 [post_content] => [post_title] => Role of Cystathionine 𝛾-lyase in Prostate Cancer Progression [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => role-of-cystathionine-y-lyase-in-prostate-cancer-progression [to_ping] => [pinged] => [post_modified] => 2021-05-11 15:05:59 [post_modified_gmt] => 2021-05-11 07:05:59 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20338 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => WANG, Lu-Hai (王陸海) [researchers_position] => Chinese Medicine Research Center, Institute of Integrated Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/lu-hai-wang.jpg [researchers_profile] => https://www.researchgate.net/scientific-contributions/Lu-Hai-Wang-39389518 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Interleukin 1 beta; Pc Progression; nf κb; Prostate Cancer; Cell Invasion; Metastasis; Cystathionine γ-lyase; γ lyase; Pc Metastasis; Cystathionine [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/GA65.jpg [video] => https://www.youtube.com/embed/JOkOiFEERUY [the_novelty] =>

A potential therapeutic target for prostate cancer (PC) metastasis was found using hydrogen sulphide (H₂S) and its enzyme, cystathionine 𝛾-lyase (CTH). The study showed CTH expression stimulated cell invasion and migration, but treatment with H₂S resulted in only cell invasion. The enzyme activity of CTH also resulted in nuclear factor-kappaB (NF-𝜅B) translocation causing an increase in interleukin 1 beta (IL-1b) expression and H₂S-induced cell invasion. The study identified the role of H₂S in blood vessel formation (angiogenesis). In some cells, CTH knockdown controlled tumor growth and spread from the primary location, whereas CTH overexpression increased tumor growth and spread to the lymph nodes in mouse models. The study suggests potential mechanisms where CTH/H₂S assists PC metastasis by promoting lymphatic vessels formation from existing lymphatic vessels. Overall, results show evidence of CTH and H₂S involvement in PC progression and metastasis through different channels.

[the_background] =>

Prostate cancer (PC) is most prevalent among men and occurs in the prostate. Most deaths from PC are linked with bone metastasis when the cancer spreads to the bone. Current treatments only prevent pain and complications. H₂S is a signaling molecule produced from enzymes such as CTH that contribute to tumor maturation in various cancers through a series of processes. NF-𝜅B activation has shown positive results suggesting a dominant role in PC metastasis development. The study investigated the relationship between CTH and H₂S in PC progression and metastasis and found that H₂S levels increased with the expression of CTH, causing activation of NF-𝜅B mediated signaling on cysteine-38 of the NF-𝜅B subunit. It was seen that the H₂S-producing enzyme, CTH level, was increased in bone metastatic PC cells. The presence of CTH and H₂S contributes to therapeutic mechanisms to intervene in PC progression and metastasis.

[the_sdg_impact] =>

According to the American Cancer Society, prostate cancer is the sixth leading cause of death by cancer in men worldwide. In the United States, an estimated 191,930 men are to be diagnosed with it in 2020 alone. Although the death rate has decreased over the past few years, the cancer is incurable. By identifying mechanisms and signaling molecules that could produce more advanced treatment options, it aligns with goal 3: Good Health and Well-being of Sustainable Development Goal. The study improves the chances of reducing the mortality rate from a non-communicable disease like prostate cancer through treatment and prevention strategies.

[article_url] => https://www.embopress.org/doi/full/10.15252/embr.201845986 [main_image] => [podcast] => [doi] => https://doi.org/10.15252/embr.201845986 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Dysregulation of cystathionine 𝛾-lyase promotes prostate cancer progression and metastasis [journal_title] => Journal of EMBO Reports [publisher] => EMBO Press [year] => August 2019 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-33.jpg ) ) [221] => WP_Post Object ( [ID] => 20332 [post_author] => 1 [post_date] => 2020-10-22 15:01:19 [post_date_gmt] => 2020-10-22 15:01:19 [post_content] => [post_title] => Risk of Potentially Inappropriate Medication Threatens the Elderly Well-being [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => risk-of-potentially-inappropriate-medication-threatens-the-elderly-well-being [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:39:48 [post_modified_gmt] => 2021-08-03 15:39:48 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20332 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ABDULAH, Rizky [researchers_position] => Department of Pharmacology and Clinical Pharmacy, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/9-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Rizky_Abdulah [researchers_second_profile] => http://orcid.org/0000-0002-8779-6421 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => indonesian geriatric population; karawang district; inappropriate medication; geriatric population; potentially inappropriate medication; primary health care; polypharmacy; adverse drug reaction; odds ratio [graphic_abstract] => [video] => [the_novelty] =>

This preliminary study identified polypharmacy as one of the main factors leading to potentially inappropriate medication (PIM) among the Indonesian elderly population. A 52.2% prevalence rate was observed within the elderly community seeking medical attention in 25 selected primary healthcare facilities in Karawang District, Indonesia. By referring to the updated Beers and McLeod criteria, a thorough analysis was conducted on both acute and chronic medical prescription records of the past. As a result, the first set of criteria of Beers and the McLeod guideline adopted provided insights on categories of drugs and dosages to be avoided by the geriatric population. By determining the factors contributing to PIM, better intervention could be practiced to prevent complications among the elderly.

[the_background] =>

It is common for older people to have multiple, co-existing medical conditions that make them susceptible to the risk of PIM. Though several evaluation techniques have been used to detect PIM, there is still a lack of clear and updated guidelines for prescribing medications for the elderly population in Indonesia. Most healthcare services acquired by the elderly start from community clinics and local dispensaries. This study aims to improve the quality of drug prescription in these facilities by assessing the prevalence and determining the factors leading to PIM among the older population. By integrating internationally accepted criteria listed under the Beers and McLeod guidelines, this study provided an up-to-date safety reference to prevent inappropriate prescribing within the subject groups.

[the_sdg_impact] =>

The United Nations, in its 2019 World Population Prospect data, projected that 1 in 6 people worldwide would be over the age of 65 by 2050. With Indonesia having the 8th largest aged population in the world, there is a dire need to improve the welfare and medical care of its elderly population. By educating the healthcare providers on safe prescription practices of drugs and the elderly on proper management of their medications, risks associated with adverse drug reactions, hospitalization, and mortality could be reduced as envisioned in Goal 3: Good Health and Well-being of the UN SDG.

[article_url] => https://www.dovepress.com/polypharmacy-leads-to-increased-prevalence-of-potentially-inappropriat-peer-reviewed-article-TCRM [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-9-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Rizky-Abdulah_1093073_1597377735.mp3 [doi] => https://doi.org/10.2147/TCRM.S170475 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Polypharmacy leads to increased prevalence of potentially inappropriate medication in the Indonesian geriatric population visiting primary care facilities [journal_title] => Journal of Therapeutics and Clinical Risk Management [publisher] => Dove Press [year] => September 2018 [subject] => Pharmacology; Clinical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/J7dnT-guelc [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Risk-of-potentially-inappropriate-medication-threatens-the-elderly-well-being.mp4_snapshot_00.01_2021.08.03_23.36.48.png [figures] => ) ) [222] => WP_Post Object ( [ID] => 20327 [post_author] => 1 [post_date] => 2020-10-22 14:58:36 [post_date_gmt] => 2020-10-22 14:58:36 [post_content] => [post_title] => Risk of Hip Disorders among Diabetic Patients [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => risk-of-hip-disorders-among-diabetic-patients [to_ping] => [pinged] => [post_modified] => 2021-05-11 15:09:15 [post_modified_gmt] => 2021-05-11 07:09:15 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20327 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LAI, Shih-Wei (賴世偉) [researchers_position] => Department of Family Medicine, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/display-photo.png [researchers_profile] => https://www.researchgate.net/scientific-contributions/39334953-Shih-Wei-Lai [researchers_second_profile] => https://orcid.org/0000-0002-7420-1572 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Incidence Rate Ratios; Hazard Ratio; Necrosis; DESIGN; Important Clinical; Retrospective Cohort Study; Real World; Clinical Issue; Avascular Necrosis; Diabetes [graphic_abstract] => [video] => https://www.youtube.com/embed/ab-dNz6DGQ4 [the_novelty] =>

This research provides evidence that diabetic patients are 1.16 times more likely to suffer from hip disorders than non-diabetics. As the first nationwide population-based cohort study, this research leverages on the National Health Insurance database of Taiwan to determine the incidence rate of hip disorders among diabetic patients in the country. It was observed that diabetic patients have a higher tendency to experience avascular necrosis (death of bone tissues due to the lack of blood supply) at the joints of the hip over a specified period. Thus, adding to the list of potential blood vessels related diseases developed in those with diabetes.

[the_background] =>

Past researches have established that patients with diabetes are prone to develop a number of illnesses post-diagnosis, many of which are caused by defects in blood vessels. However, there is a lack of evidence to associate diabetes with hip disorders resulting from the death of blood vessels around the femoral head. By measuring the incidence of blood supply defects at joints of the hip reported clinically in Taiwan, a positive correlation was established, proving diabetic patients are of higher risk than non-diabetic patients. The findings of this research serve as literature evidence to further examine the link between diabetes and the risk of developing avascular necrosis of the hip joints, as well as the effect controlling diabetes could have on this risk.

[the_sdg_impact] =>

It was reported by WHO that approximately 422 million people worldwide are diagnosed with diabetes, and a devastating 1.6 million die each year as an effect of this disease. Apart from death, diabetes also contributes to numerous forms of health complications, disabilities, and activity limitations if poorly controlled. By examining the prevalence rate of avascular necrosis of the hip joints among diabetic patients, this research provides healthcare policymakers the evidence to start working on the treatment, prevention, and rehabilitation measures to address this issue. This aligns perfectly with targets of Goal 3: Good health and well-being of Sustainable Development Goals, to reduce premature mortality from non-communicable diseases and to promote well-being for all persons with disabilities.

[article_url] => https://care.diabetesjournals.org/content/42/1/39 [main_image] => [podcast] => [doi] => https://doi.org/10.2337/dc18-1258 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Real-World Database Examining the Association Between Avascular Necrosis of the Femoral Head and Diabetes in Taiwan [journal_title] => Diabetes Care [publisher] => American Diabetes Association [year] => January 2019 [subject] => Medical; Diabetes ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-34.jpg ) ) [223] => WP_Post Object ( [ID] => 20317 [post_author] => 1 [post_date] => 2020-10-22 14:55:28 [post_date_gmt] => 2020-10-22 14:55:28 [post_content] => [post_title] => Religious Intolerance: The Socio-Economic Variables Behind It [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => religious-intolerance-the-socio-economic-variables-behind-it [to_ping] => [pinged] => [post_modified] => 2021-05-12 10:37:59 [post_modified_gmt] => 2021-05-12 02:37:59 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20317 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YUSUF, Arief [researchers_position] => Department of Economics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/41.jpg [researchers_profile] => https://www.researchgate.net/scientific-contributions/Arief-Anshory-Yusuf-12578046 [researchers_second_profile] => https://orcid.org/0000-0002-3126-3853 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => religious freedom; socio economic; Lembaga Survei Indonesia; Indonesian Family Life Survey; individual income; regression analysis; Indonesia; religious intolerance; conservatism individual level [graphic_abstract] => [video] => [the_novelty] =>

To curb religious intolerance, this study investigated several socio-economic variables affecting the individual-level religious intolerance in Indonesia. It found out that the rapid rise of income inequality and the increasing trend of Islamic conservatism were among the most robust variables of religious intolerance. Meanwhile, higher individual income and educational attainment were positively correlated with the tolerance level of different faith. On the other hand, a higher level of self-declared religiosity was negatively correlated with a tolerant attitude. Panel data from 2007 and 2014 of more than 20,000 adult individuals were analyzed using fixed-effect regression analysis. The scope of this study can be expanded by assessing the causation of religious intolerance based on the reported socio-economic variables.

[the_background] =>

Religious tensions and violence have risen globally over the last decade. It has been reported that Indonesia is one of the top five populous countries with the highest levels of religious freedom restriction. Furthermore, according to several micro-level surveys, religious intolerance among Indonesians has also been on the rise. To address such an alarming state, this study was conducted to identify the socio-economic variables affecting religious intolerance. Based on the results, the study also proposed several policies to be established so as to reduce religious intolerance in Indonesia.

[the_sdg_impact] =>

In 2018, the Minority Rights Group International recorded that mass killings and other atrocities involving religious minorities have been increasing in many countries. By carrying out this study, policies can be made to overcome the socio-economic variables affecting religious intolerance. Such an effort is important to maintain harmony and safety among the Indonesians. Since the UN targets to significantly reduce all forms of violence and related death rates everywhere, these findings will help to achieve Goal 16: Peace, Justice and Strong Institutions of the UN’s Sustainable Development Goals.

[article_url] => https://www.mdpi.com/2077-1444/11/1/21 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-41-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Arief-Yusuf_1647661_1599975719.mp3 [doi] => https://doi.org/10.3390/rel11010021 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => On Socio-Economic Predictors of Religious Intolerance: Evidence from a Large-Scale Longitudinal Survey in the Largest Muslim Democracy [journal_title] => The Religions [publisher] => MDPI [year] => December 2019 [subject] => Economics; Religion ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/mT9gvVsOg3Y [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/43-w-subs-music.mp4_snapshot_00.01_2021.05.12_10.36.10.jpg ) ) [224] => WP_Post Object ( [ID] => 20171 [post_author] => 1 [post_date] => 2020-10-10 16:49:31 [post_date_gmt] => 2020-10-10 16:49:31 [post_content] => [post_title] => Probiotics-based Diet Boosts New Zealand Black-footed Abalone’s Immunity [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => probiotics-based-diet-boosts-new-zealand-black-footed-abalones-immunity [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:42:24 [post_modified_gmt] => 2021-08-03 15:42:24 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20171 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => GRANDIOSA, Roffi [researchers_position] => Department of Fisheries, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/10.jpg [researchers_profile] => https://www.researchgate.net/profile/Roffi_Grandiosa2 [researchers_second_profile] => https://orcid.org/0000-0003-0498-7220 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Immunology; Metabolomics; Abalone; Apoptosis; H. iris; probiotic fed; bacteria; H. midae; haemocyte; probiotics; reactive oxygen species; Haliotis iris [graphic_abstract] => [video] => [the_novelty] =>

This study is the first to report that a probiotics-based diet improved the immune system of juvenile New Zealand black-footed abalone. Based on the observation of total haemocyte count, cell growth and death rate, and production of reactive oxygen species (ROS), it was evident that the abalones fed with probiotics developed stronger immunity. Metabolic profiling also revealed improved growth and survival rates of the probiotics-fed abalones. These findings are intended to strengthen future development and application of probiotics in aquaculture of, not only New Zealand black-footed abalone, but also other shellfish.

[the_background] =>

Haliotis iris (H. iris), commonly known as New Zealand black-footed abalone, is a type of shellfish that contributes to the aquaculture sector in New Zealand. Although past studies have reported optimal nutritional and environmental parameters for the growth of juvenile H. iris, disease outbreaks caused by pathogenic bacteria and viruses continue to threaten this farmed shellfish industry. The administration of antibiotics only serves as a short-term treatment, which also poses safety concerns in terms of antibiotic-resistant infection as well as undesirable environmental impacts. Therefore, as a follow up of the research group’s previous findings, the application of probiotics in the dietary plan was introduced as a more environmentally friendly and effective solution in this study.

[the_sdg_impact] =>

Haliotis iris (H. iris) is one of the largest blackfoot abalones, and it is found only in New Zealand water. The flesh of this shellfish is a delicacy in New Zealand, France, East Asia, and parts of Latin America, thus, creating a demand for it in the aquaculture sector. The huge capital needed to sustain these shellfish farms is mostly due to its vulnerability to diseases caused by bacteria or viruses. In alignment with the UN Sustainable Development Goal 14: Life below water, this study provides scientific evidence to maintaining the population of the abalone as well as improving the restoration process of the stock by improving its immunity and growth rate.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S1050464818305096 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-10-1024x576-1.jpg [podcast] => [doi] => https://doi.org/10.1016/j.fsi.2018.08.034 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Multi-strain probiotics enhance immune responsiveness and alters metabolic profiles in the New Zealand black-footed abalone (Haliotis iris) [journal_title] => Journal of Fish & Shellfish Immunology [publisher] => Elsevier [year] => November 2018 [subject] => Fisheries ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/9pHZADHrRbs [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Probiotics-based-diet-boosts-New-Zealand-black-footed-abalones-immunity.mp4_snapshot_00.01_2021.08.03_23.40.44.png [figures] => ) ) [225] => WP_Post Object ( [ID] => 20168 [post_author] => 1 [post_date] => 2020-10-10 16:46:11 [post_date_gmt] => 2020-10-10 16:46:11 [post_content] => [post_title] => Practice Guidelines for Omega-3 Fatty Acids Prescription as Depression Treatment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => practice-guidelines-for-omega-3-fatty-acids-prescription-as-depression-treatment [to_ping] => [pinged] => [post_modified] => 2021-05-11 15:10:54 [post_modified_gmt] => 2021-05-11 07:10:54 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20168 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SU, Kuan-Pin (蘇冠賓) [researchers_position] => Departments of Psychiatry, and Mind-Body Interface Laboratory, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/Kuan.png [researchers_profile] => https://www.researchgate.net/profile/Kuan-Pin_Su [researchers_second_profile] => https://orcid.org/0000-0002-4501-2502 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Fatty Acid; PUFA; n–3 Pufas; Docosahexaenoic Acid; Randomized Controlled Trials; Eicosapentaenoic Acid; Practice Guideline; Guideline; Major Depressive Disorder; Ppsychiatry [graphic_abstract] => [video] => https://www.youtube.com/embed/1V5BmLawFe0 [the_novelty] =>

This research established the first international consensus-based practice guideline for prescribing Omega-3 fatty acids (n-3 PUFAs) to treat major depressive disorder (MDD). An advisory panel consisting of experts from the International Society for Nutritional Psychiatry Research (ISNPR) centered the practice guideline on 5 major themes. A set of 12 comprehensive clinical recommendations were drafted based on these key areas identified through systematic literature review, survey, and expert sharing. This research emphasized that prior to prescribing n-3 PUFAs as an alternative treatment for MDD, accurate clinical diagnosis and measurement-based psychopathological assessments should be carried out.

[the_background] =>

Existing antidepressants used to treat moderate to severe symptoms of MDD are effective for only a small group of patients and is said to have various side effects. Past researches have shown n-3 PUFA to be a promising preventive and treatment method for MDD. However, despite the findings, there is a lack of clinical practice guidelines to aid clinicians in prescribing n-3 PUFA. In order to provide an effective practice guideline, this research gathered the consensus from experts of ISNPR, identified the need to personalize MDD treatment according to subgroups, and encouraged the adoption of a transparent communication system between clinicians and patients.

[the_sdg_impact] =>

According to WHO, more than 264 million people suffer from depression, one of the most common illness and the leading cause of disability worldwide. In the United States alone, approximately 17.3 million adults aged 18 and above have experienced episodes of major depressive disorder in 2017. Although effective treatment options are available, there are still 76% to 85% of patients from low- or middle-income countries who are deprived of these treatments. With that said, the aim of this research aligns well with “Goal 3: Good Health and Well-Being” of the UN’s Sustainable Development Goals (SDG). As one of the targets under this goal is to “reduce premature mortality from non-communicable diseases through prevention and treatment and promote mental health and well-being,” the guidelines provided in this article will help clinicians worldwide to get a step closer to achieving this target successfully.

[article_url] => https://www.karger.com/Article/FullText/502652 [main_image] => [podcast] => [doi] => https://doi.org/10.1159/000502652 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder [journal_title] => Journal of Psychotherapy and Psychosomatics [publisher] => Karger Publishing [year] => September 2019 [subject] => Medical; Depression ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-28.jpg ) ) [226] => WP_Post Object ( [ID] => 20157 [post_author] => 1 [post_date] => 2020-10-10 16:34:22 [post_date_gmt] => 2020-10-10 16:34:22 [post_content] => [post_title] => Potential Dengue Outbreak Forecast Tool [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => potential-dengue-outbreak-forecast-tool [to_ping] => [pinged] => [post_modified] => 2021-07-19 11:24:42 [post_modified_gmt] => 2021-07-19 03:24:42 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20157 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => JAYA, Mindra [researchers_position] => Department of Statistics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/23.jpg [researchers_profile] => https://www.researchgate.net/profile/Mindra_Jaya [researchers_second_profile] => https://orcid.org/0000-0003-1391-4138 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => marginal predictive likelihood; Bayes factor; intrinsic conditional autoregressive; negative binomial; Dengue disease; laplace approximation; deviance information criterion; Watanabe–Akaike information criterion; Integrated nested Laplace approximation [graphic_abstract] => [video] => [the_novelty] =>

This study suggested a potential early warning system for dengue outbreaks using the Bayesian spatiotemporal random effects (pure) model and continuous isopleth mapping. When dengue incidence data from 30 districts of Bandung, Indonesia, was analyzed in terms of geographical positioning and seasons, results showed a decrease in disease risk from 2014 onwards. However, the forecast for certain districts, based on their socio-economic status, weather conditions and geographical landscapes, still predicts a higher risk of the outbreak for the year 2017. Thus, enabling further research on the association between relative risk and potential risk factors through region and time pattern analysis.

[the_background] =>

Dengue fever, a common vector-borne disease transmitted through mosquito bites in tropical and sub-tropical regions, tends to cause severe health issues and fatality. Due to the costly vaccination and antiviral therapies, the most desirable measure is prevention. For effective preventive and control measures to be implemented, an early warning system is needed. Several previous studies have neglected the weather patterns based on the time of the year when it comes to forecasting the relative risk of infectious diseases. By analyzing the incidence rate of the disease based on the regions and across different timelines, this study provides a more accurate forecast tool to predict the next dengue outbreak. Besides, it also allows potential disease risk factors to be identified, which encourages specific actions to be initiated to control the transmission.

[the_sdg_impact] =>

Dengue is a form of infectious disease that is currently terrorizing half of the world’s population. According to WHO, an estimated 100 to 400 million dengue cases are reported worldwide every year. This study aligns with the UN’s SDG 3: Good health and well-being by providing a reliable and accurate early warning system to detect potential dengue rise. Hence, it allows the authorities and the people sufficient time to practice preventive measures. Similarly, the suggested model could also be further explored to forecast and control other infectious diseases.

[article_url] => https://link.springer.com/article/10.1007/s10109-019-00311-4 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-23-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/I-Gede-Nyoman-Mindra-Jaya_1132434_1597560370.mp3 [doi] => https://doi.org/10.1007/s10109-019-00311-4 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Bayesian spatiotemporal mapping of relative dengue disease risk in Bandung, Indonesia [journal_title] => Journal of Geographical Systems [publisher] => Springer Nature [year] => August 2019 [subject] => Medical; Dengue ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/utcODltpbdI [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Potential-Dengue-Outbreak-Forecast-Tool.mp4_snapshot_00.01_2021.07.16_12.02.32.png ) ) [227] => WP_Post Object ( [ID] => 20151 [post_author] => 1 [post_date] => 2020-10-10 16:31:42 [post_date_gmt] => 2020-10-10 16:31:42 [post_content] => [post_title] => Hydropower Sustainability vs Water Condition of Reservoir [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => hydropower-sustainability-vs-water-condition-of-reservoir [to_ping] => [pinged] => [post_modified] => 2021-06-26 12:23:24 [post_modified_gmt] => 2021-06-26 04:23:24 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20151 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SURNADI, Surnadi [researchers_position] => Department of Biologi, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/22.jpg [researchers_profile] => https://www.researchgate.net/profile/Sunardi_Sunardi7 [researchers_second_profile] => https://orcid.org/0000-0002-7972-3580 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => hydro mechanical equipment; cirata reservoirl water corrosivityl water qualityl water corrosiveness; saturation indexl calcium; energy supply; corrosive; langelier saturation index [graphic_abstract] => [video] => [the_novelty] =>

By assessing 10 years’ worth of water quality data of the Cirata Reservoir, this study concludes that the corrosiveness of its water is a threat to the continuity of the hydropower operations powering Java and Bali. Records from 20 sampling stations in the reservoir showed increased efforts on maintaining the hydro-mechanical equipment as a result of the worsening water quality. External factors, like agricultural, domestic, and industrial activities, taking place surrounding the catchment, and internal factors, like excessive aquaculture food residuals from floating cages, were identified as the cause of this severe water pollution. Hence, the findings on the sources intensifying water corrosiveness, which damaged the hydropower operations, could be used to develop sustainable strategies to overcome such issues in the future.

[the_background] =>

The roles of water reservoirs extend from merely supplying water to cities to the development of aquaculture, flood control, and powering hydroelectricity. The Cirata Reservoir is made from 9 rivers flowing into it with various human activities taking place around and within its catchment area. These socioeconomic activities have been causing a bloom in microalgae growth due to the excessive flow of organic matters into the water source, along with dissolved and suspended solids. Therefore, this study assessed the impact of these activities on the integrity of the concrete structures of the hydropower plant. The findings are expected to provide vital insights into how water quality could affect the sustainability of hydropower.

[the_sdg_impact] =>

In 2019, the World Bank reported that the deteriorating water quality worldwide is severely jeopardizing the economic potential of the heavily polluted areas. It warns that in case no recovery and preventive actions are taken, this crisis could eventually threaten the human and environmental well-being. This study elaborates on water pollution could also affect the operations of hydropower plants. By identifying the root causes of water quality degradation and its impact on hydropower operations, strategic plans could be adopted to improve the situation. As mentioned in UN SDG 7: Affordable and Clean Energy, appropriate upgrading of the hydropower technology could be implemented for sustainability, as well as in UN SDG 6: Clean Water and Sanitation, effective water pollution control measures could be put in place to overcome this concerning water crisis.

[article_url] => https://www.nature.com/articles/s41598-020-68026-x [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-22-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Surnadi-Surnadi_1132228_1597559031.mp3 [doi] => https://doi.org/10.1038/s41598-020-68026-x [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Water corrosivity of polluted reservoir and hydropower sustainability [journal_title] => Scientific Reports [publisher] => Springer Nature [year] => July 2020 [subject] => Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/_y4b2yLRheY [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/51-w-subs-music.mp4_snapshot_00.01_2021.05.12_11.02.01.jpg ) ) [228] => WP_Post Object ( [ID] => 20144 [post_author] => 1 [post_date] => 2020-10-10 16:28:52 [post_date_gmt] => 2020-10-10 16:28:52 [post_content] => [post_title] => Optimizing the Setting Atmosphere for Apatite Cement [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => optimizing-the-setting-atmosphere-for-apatite-cement [to_ping] => [pinged] => [post_modified] => 2021-08-14 11:22:40 [post_modified_gmt] => 2021-08-14 03:22:40 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20144 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CAHYANTO, Arief [researchers_position] => Department of Dental Materials Science and Technology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/51.jpg [researchers_profile] => https://www.researchgate.net/profile/Arief_Cahyanto [researchers_second_profile] => http://orcid.org/0000-0003-2222-5895 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => TTCP; dissolution precipitation reaction; dicalcium phosphate; unreacted ttcp; Fourier Transform-Infrared spectroscopy; bone defect; Apatite cementco2 atmosphere; Carbonate apatite; Setting atmosphere [graphic_abstract] => [video] => [the_novelty] =>

In an attempt to understand the role of setting atmosphere on apatite cement resorption, this study reported that the amount of replacement of apatite cement with bone was greater in the order of 100% CO2 and 5% CO2, followed by 0% CO2. The presence of CO2 in setting atmosphere induced the formation of carbonate apatite that came into contact with body environments. The effect of setting atmosphere was studied using in vitro and in vivo approaches. Since carbonate apatite was also formed at 0% CO2, future studies can be carried out to investigate the root cause as there is still no proper explanation for it.

[the_background] =>

Apatite cement has been used in bone reconstruction for its superior tissue response and good osteoconductivity. Despite many studies reported that the apatite cement implant can eventually be replaced with bone completely, some studies have also reported otherwise. Meanwhile, studies showed that carbonate apatite was replaced with a bone when implanted into bony defects. Hence, it was hypothesized that the apatite cement might have transformed to carbonate apatite (when coming in contact with the body environment) prior to being replaced with bone. To establish a better understanding of the transformation that takes place after implantation, this study was conducted to examine the effect of setting atmosphere on apatite cement resorption.

[the_sdg_impact] =>

One of the most common methods to treat bone defects is by using apatite cement implant. The results of this study have shown how apatite cement can be transformed into carbonate apatite effectively by controlling the setting atmosphere. With the higher rate of transformation, the duration needed for bone repair is shortened. Since the UN aims to support domestic technology development, research and innovation, this study carries significance in achieving UNSDG 9: Industrial, Innovation and Infrastructure, as well as mildly contributes to UNSDG 3: Good health and well-being.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S1751616118309068 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-51-1-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Arief-Cahyanto_1758696_1600490399.mp3 [doi] => https://doi.org/10.1016/j.jmbbm.2018.08.021 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Effect of setting atmosphere on apatite cement resorption: An in vitro and in vivo study [journal_title] => Journal of Mechanical Behavior of Biomedical Materials [publisher] => Elsevier [year] => December 2018 [subject] => Dental; Biomedical Materials ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/L1sIIukh8QE [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/50-w-subs-music.mp4_snapshot_00.01_2021.05.12_10.59.21.jpg [figures] => ) ) [229] => WP_Post Object ( [ID] => 20139 [post_author] => 1 [post_date] => 2020-10-10 16:26:11 [post_date_gmt] => 2020-10-10 08:26:11 [post_content] => [post_title] => Novel Strategy to Synthesis of Benzo-1,3,4-oxadiazepine Derivatives [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => novel-strategy-to-synthesis-of-benzo-134-oxadiazepine-derivatives [to_ping] => [pinged] => [post_modified] => 2021-09-20 16:06:13 [post_modified_gmt] => 2021-09-20 08:06:13 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20139 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LEE, Yean-Kee [researchers_position] => University of Malaya | UM · Department of Chemistry [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/download-2-231x300-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Lee_Yean-Kee [researchers_second_profile] => https://orcid.org/0000-0002-6911-2073 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Membered Benzo1,3,4; Synthesis; Cyclization; Alzheimers Disease; Benzo-1,3,4-oxadiazepine; Oxadiazepine Derivative; Brønsted acids; Intramolecular Cyclization; Hydrazones; Substituent Effects; Step Intramolecular [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/223.png [video] => [the_novelty] =>

Benzoxadiazepines have been reported to bring valuable medical and industrial benefits. Nonetheless, there are not many remarkable published studies on the synthesis of benzoxadiazepines. To be more specific, the rare seven-member benzo-1,3,4-oxadiazepine is known to be a biologically active compound. Hence, this research focuses on the synthesis of this rare compound via simple steps. In the study, the effects of different reaction conditions, substituent and mixing protocols on the synthesis were examined. As a result, a series of benzo-1,3,4-oxadiazepine derivatives were successfully prepared with a yield of 83 % via a set of facile procedures.

[the_background] =>

Benzoxadiazepines are gaining attention for their significant activities as antibacterial, muscle relaxant, stimulant to the central nervous system, tranquilizer, anticonvulsant, and pesticides. The full potential of this compound to human’s well-being is yet to be fully understood. In order to contribute to the continuity of such studies, the synthesis of benzo-1,3,4-oxadiazepine has been established. The reported synthesis method can achieve a yield of 83 %. Such high efficiency in the synthesis is vital in facilitating scientists in the exploration of the real potential of benzoxadiazepines.

[the_sdg_impact] =>

This study aims to achieve “Goal 3: Good Health and Well-being” of the UN’s Sustainable Development Goals (SDG). The outcome of the research proves the ease with which this rare compound could be synthesized and transformed into various derivatives. Further exploration of the biological potentials of these compounds, such as anti-viral and anti-cancer properties, would indeed primarily benefit the medical industries to improve the quality of life.

[article_url] => https://onlinelibrary.wiley.com/doi/abs/10.1002/ajoc.201800014 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/s3x-1629-885-987-768x463-1.jpg [podcast] => [doi] => https://doi.org/10.1002/ajoc.201800014 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Facile Intramolecular Cyclization of N -(2-Hydroxybenzoyl)hydrazones to N ,N′ -Diacetyl Benzo-1,3,4-oxadiazepine Derivatives [journal_title] => Asian Journal of Organic Chemistry [publisher] => Wiley Publishing [year] => February 2018 [subject] => Organic Chemistry ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [230] => WP_Post Object ( [ID] => 20133 [post_author] => 1 [post_date] => 2020-10-10 16:23:34 [post_date_gmt] => 2020-10-10 16:23:34 [post_content] => [post_title] => Non-invasive CT Thermometry in Hyperthermia Cancer Treatment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => non-invasive-ct-thermometry-in-hyperthermia-cancer-treatment [to_ping] => [pinged] => [post_modified] => 2021-07-19 13:05:03 [post_modified_gmt] => 2021-07-19 05:05:03 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20133 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LIM, Kok-Sing [researchers_position] => University of Malaya | UM · Photonics Research Centre [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/Kok-Sing_Lim2-150x150-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Kok-Sing_Lim2 [researchers_second_profile] => https://orcid.org/0000-0003-0631-6682 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Fiber Bragg Grating; Magnetic Resonance Imaging; Tomography; Radiofrequency Ablation; Hepatocellular Carcinoma; Computed Tomography; Thermal Ablation; Tissue Temperature; Microwave Ablation; Laser Induced Interstitial Thermotherapy [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/Optical-Fiber-01-scaled.jpg [video] => [the_novelty] =>

This study aims to reduce or possibly eliminate the use of contrast medium needed for CT imaging to identify the target region for surgical removal in the organ by using non-invasive CT thermometry. Through the experimentation on bovine liver samples, the association between tissue temperature and CT number counts are observed. Cancer patients, particularly those with liver cancer receiving hyperthermia treatment, are to benefit through this research. Support and more comprehensive data on CT images and tumour conditions are required from physicians/radiologist/radiographer/medical physicist for further investigation and perfecting this research.

[the_background] =>

The existing procedure used in the evaluation of unresectable liver tumours relies heavily on visual inspection of contrasted CT image. Though widely practiced, this procedure has shown cases of patients being allergic to the medium, and the process tends to cause patient discomfort. Hence, the development of a CT-tissue temperature conversion model as an alternative tool could provide attending physicians the additional information of the target region as well as expedite patient recovery due to its non-invasive nature. The outcome of this research could potentially alter the current hyperthermia treatment procedures for cancer patients.

[the_sdg_impact] =>

Cancer is the second leading cause of death globally and the fourth most common cause of death in Malaysia. Iodinated contrast used in CT scan has mild side effects including nausea and vomiting, headache, itching, flushing, mild skin rash or hives and can also trigger a life-threatening reaction in a few cases. A new approach is required to improve the diagnosis and to reduce the reliance of drug with side effects for cancer patients as well as improving treatment efficacy. This research will further need to engage with radiologists to acquire more real patient data for analysis and proof of concept and also with CT-scanner manufacturer for collaboration, which may benefit the study and treatment outcome. In compliance with the UN’s third Sustainable Development Goal, this study aims to ensure healthy lives and promote well-being for all at all ages through the improvement of existing medical procedures.

[article_url] => https://iopscience.iop.org/article/10.1088/1742-6596/1248/1/012039 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/photo-1551884170-09fb70a3a2ed-768x508-1.jpg [podcast] => [doi] => https://doi.org/10.1088/1742-6596/1248/1/012039 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Correlation between CT Number shift and tissue temperature change during radiofrequency ablation: an ex-vivo study using bovine liver [journal_title] => Journal of Physics Conference Series [publisher] => Institute of Physics Publishing [year] => June 2019 [subject] => Medical and Health Sciences; Clinical Sciences ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [231] => WP_Post Object ( [ID] => 20127 [post_author] => 1 [post_date] => 2020-10-10 16:20:38 [post_date_gmt] => 2020-10-10 16:20:38 [post_content] => [post_title] => Negative Impact of Homegarden Commercialization on Food Security & Food Sovereignty [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => negative-impact-of-homegarden-commercialization-on-food-security-food-sovereignty [to_ping] => [pinged] => [post_modified] => 2021-05-12 10:47:11 [post_modified_gmt] => 2021-05-12 02:47:11 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20127 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ABDOELLAH S, Oekan [researchers_position] => Department of Anthropology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/50.jpg [researchers_profile] => https://www.researchgate.net/profile/Oekan_Abdoellah [researchers_second_profile] => https://orcid.org/0000-0002-3640-1485 ) [research_footprints] => household food security; household head; food security; structural equations model; Homegardens; homegarden commercialization; indonesia; Food sovereignty; standard deviation; upper citarum watershed [original_article_reference] => [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1007/s11625-020-00788-9 [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Oekan-S.-Abdoellah_1758721_1600490657.mp3 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-50-1024x576-1.jpg [article_url] => https://link.springer.com/article/10.1007/s11625-020-00788-9 [the_sdg_impact] =>

The benefits of homegardens are such as serving as a buffer against food price shocks, a source of fresh food, and a space of self-determination. Moreover, the use of synthetic fertilizers, pesticides, and herbicides is significantly lower for homegardens. This study reported the current state of homegardens commercialization to highlight its negative effect on food security and food sovereignty. In turn, this helps to ensure policies are made to help avoid food price shocks and to maintain sufficient food supply to the locals, especially for poor rural households. As the UN targets to end poverty and hunger, the effort of this study is important to achieve the Sustainable Development Goal 1: No Poverty and Goal 2: Zero Hunger in which people can easily have access to food supply without overpaying for it.

[the_background] =>

Agriculture has become increasingly commercialized and industrialized. To keep up with these developments, policies and markets encourage farmers to manage farming activities according to buyer–driver commodity chains. Due to this phenomenon, homegarden owners are also pressured to transform the land around their dwellings into an income-generating space by planting commercial crops for sale in urban and processing markets. Thus, this study was conducted to provide insights into the current state of homegarden commercialization and its effects on food security and food sovereignty. Food security is a measure of the availability of food and individuals’ ability to access it. Food sovereignty asserts that the people who produce, distribute, and consume food should control the mechanisms and policies of food production and distribution.

[the_novelty] =>

To provide a better understanding of the current status of homegarden commercialization, this study has reported that homegarden commercialization is proceeding rapidly in the Upper Citarum Watershed in West Java, Indonesia. On the other hand, this has created negative effects on household food security and food sovereignty, as well as contributed to the spread of monocultural production in the region. Both quantitative and qualitative approaches were applied to survey 81 village households involved in agricultural production there. For future studies, in-depth investigations should be carried out to redesign homegardens to ensure sustainable consumption and production patterns; strengthening local social cohesion; and in reducing pollution caused by agrochemicals to ensure healthy lives for sustainable rural development.

[video] => [graphic_abstract] => [original_article_reference_fields] => Array ( [publication_title] => Homegarden commercialization: extent, household characteristics, and effect on food security and food sovereignty in Rural Indonesia [journal_title] => Journal of Sustainable Production and Consumption [publisher] => Springer Nature [year] => March 2020 [subject] => Anthropology; Food Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/OgZrVqxSU8g [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/48-w-subs-music.mp4_snapshot_00.01_2021.05.12_10.45.53.jpg ) ) [232] => WP_Post Object ( [ID] => 20121 [post_author] => 1 [post_date] => 2020-10-10 16:17:24 [post_date_gmt] => 2020-10-10 16:17:24 [post_content] => [post_title] => Nation’s First Health-status Measuring Instrument Value Set [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => nations-first-health-status-measuring-instrument-value-set [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:46:47 [post_modified_gmt] => 2021-08-03 15:46:47 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20121 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PURBA, Fedrick Dermawan [researchers_position] => Department of Developmental Psychology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/30.jpg [researchers_profile] => https://www.researchgate.net/profile/Fredrick_Purba [researchers_second_profile] => https://orcid.org/0000-0002-7336-3043 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => value set; EQ-5D; health technology assessment; eq 5d 5l value; hybrid model; discrete choice experiments; quality control; Time trade-off; composite time trade-off [graphic_abstract] => [video] => [the_novelty] =>

This study has successfully created the first EQ-5D-5L value set to measure the health status of Indonesians. The respondents selected for the study were similar to those of the diverse Indonesian population in terms of residence, gender, age, level of education, ethnicity, and religion. Hence, making this instrument suitable for health economic evaluations that will benefit the national health insurance scheme. The reliability of the study outcome was justified by arranging local experts to engage with the respondents to overcome the language and belief system barriers.

[the_background] =>

The EQ-5D is a standard tool used by many countries to evaluate the population’s health-related quality of life. It is measured based on 5 health dimensions, namely mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. In the context of Indonesia, there isn’t any EQ-5D value set that based on national preferences that can be used as a reference by the government to improve the nation’s healthcare facilities. However, the government has introduced universal health insurance to improve healthcare accessibility for its people. This study showed that in measuring and valuing the quality of life based on health and economic consideration, Indonesia could set up a proper health technology assessment (HTA) like other leading countries too. The findings could also be used to drive appropriate policy implementations to improve the quality of life of the Indonesian population.

[the_sdg_impact] =>

The UN global goals for sustainable development, specifically SDG 3: Good health and well-being, addressed the need for universal health coverage, including financial risk, protection, and access to quality essential healthcare services. The significance of this study in providing Indonesia its first reliable health-status measurement tool proved to be very much aligned with the UN’s aims. The results could be referred by the government to promote and facilitate health economic evaluations in Indonesia, eventually making an informed decision on the resource allocations.

[article_url] => https://link.springer.com/article/10.1007/s40273-017-0538-9 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-30-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Fedrick-Dermawan-Purba_1525266_1599395769.mp3 [doi] => https://doi.org/10.1007/s40273-017-0538-9 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The Indonesian EQ-5D-5L Value Set [journal_title] => Journal of Pharmaco Economics [publisher] => Springer Nature [year] => July 2017 [subject] => Psychology; Medical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/xFTwFyjQSTo [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Nations-first-health-status-measuring-instrument-value-set.mp4_snapshot_00.03_2021.08.03_23.45.08.png [figures] => ) ) [233] => WP_Post Object ( [ID] => 20115 [post_author] => 1 [post_date] => 2020-10-10 16:11:28 [post_date_gmt] => 2020-10-10 16:11:28 [post_content] => [post_title] => Mutations in Inherited Genes lead to Hirschsprung Disease (HSCR) [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => mutations-in-inherited-genes-lead-to-hirschsprung-disease-hscr [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:44:29 [post_modified_gmt] => 2021-08-03 15:44:29 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20115 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SRIBUDIANI, Yunia [researchers_position] => Department of Biomedical Sciences, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/29.jpg [researchers_profile] => https://www.researchgate.net/profile/Yunia_Sribudiani3 [researchers_second_profile] => https://orcid.org/0000-0003-1985-3292 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => glial cell–derived neurotrophic factor; Indian hedgehog gene; GLI family zinc finger 3; lipopolysaccharide responsive beige-like anchor; enteric neuron; enteric nervous system; ret proto-oncogene; mab-21 like gene; human embryonic kidney cells; Hirschsprung disease [graphic_abstract] => [video] => [the_novelty] =>

This study provided evidence that Hirschsprung disease (HSCR) inheritance is indeed linked to the mutation of Rearranged during Transfection (RET) gene and Glial Cell-Derived Neurotrophic Factor (GDNF) gene. A novel attempt to delete the GDNF gene along with 2 other inherited variants, IHH and GLI3, which in turn, reduced the RET activation, proved the major role these variants played in the development of HSCR disease. This study was based on a large Dutch family with a history of HSCR, and the genetic nature of the disease was identified using human embryonic kidney cell cultures and zebrafish models.

[the_background] =>

Though some of the Hirschsprung disease (HSCR) is known to be an inherited disorder, its exact genetic cause is unknown in about 40 – 50% of the cases. GDNF mutations have been previously reported in past cases of HSCR, yet they are said to be insufficient to cause the disease on their own; thus, the variants identified in IHH and GL13, in this case, are predicted to be the accompanying factors. This newly discovered GDNF mutation, in combination with the 2 inherited variants in the member of the Hh pathway (IHH and GLI3), had also changed genetic counseling, highlighting the high genetic complexity of this disorder. Hence, there is a need to consider other unrelated HSCR gene in both areas of research and clinical diagnosis. This study could potentially serve as a reference for any future similar research of this rather rare disease.

[the_sdg_impact] =>

This study further reinforced that HSCR is not only a complex genetic disorder that could be caused by a mutation in several genes, but also, despite that in some cases HSCR is inheritable, there is still high genetic complexity unknown in familial cases. In most cases, the absence of ganglion cells in the biopsy of rectum confirms the diagnosis. However, if there is the presence of other abnormalities, genetic counseling would be required to establish the underlying diagnosis further. This study proves to be an excellent source of reference to greater insights on the genetic mutations involved in HSCR, giving future genetic counseling and genetic tests more accuracy, given the rarity of this disease. This is very much in alignment with the aims of UN SDG 3: Good health and well-being, to improve the quality of life by promoting medical researches.

[article_url] => https://www.sciencedirect.com/science/article/pii/S001650851830341X [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-29-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Yunia-Sribudiani_1524800_1599393488.mp3 [doi] => https://doi.org/10.1053/j.gastro.2018.03.034 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Identification of Variants in RET and IHH Pathway Members in a Large Family With History of Hirschsprung Disease [journal_title] => Journal of Gastroenterology [publisher] => Elsevier [year] => July 2018 [subject] => Medical; Biomedical Sciences ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/8FHikgtu0HI [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Mutations-in-Inherited-Genes-lead-to-Hirschsprung-disease-HSCR.mp4_snapshot_00.01_2021.08.03_23.43.05.png [figures] => ) ) [234] => WP_Post Object ( [ID] => 20108 [post_author] => 1 [post_date] => 2020-10-10 16:07:24 [post_date_gmt] => 2020-10-10 16:07:24 [post_content] =>

Mutations Alter Postharvest Tomato

Shelf Life and Nutrients

[post_title] => Mutations Alter Postharvest Tomato Shelf Life and Nutrients [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => mutations-alter-postharvest-tomato-shelf-life-and-nutrients [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:30:43 [post_modified_gmt] => 2021-08-03 15:30:43 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20108 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MUBAROK, Syariful [researchers_position] => Department of Agronomy, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/28.jpg [researchers_profile] => https://www.researchgate.net/profile/Syariful_Mubarok [researchers_second_profile] => http://orcid.org/0000-0002-0890-3090 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => fruit shelf life; Antioxidant; tomato fruit; Mutation; total soluble solids; Fruit ripening; Duncan Multiple Range Test; fruit maturation; titratable acidity; water content [graphic_abstract] => [video] => [the_novelty] =>

This study proved that Sletr-1 and Sletr-2 mutations on ethylene receptor gene (SlETR1) have significant impacts on the nutritional and antioxidant contents of tomato fruits. The results of this study were based on the evaluation of mutant lines, maturation stage and their interactions. Among the traits affected were the water content, total soluble solids (TSS), total sugar, acidity level, lycopene, β-carotene, chlorophyll-a and -b, and total flavonoid. When compared between Sletr-1 and Sletr-2 mutant lines, the latter showed promising results in improving the postharvest shelf life, quality and nutritional values of tomato fruits.

[the_background] =>

Ethylene is a plant hormone responsible for fruit ripening in tomatoes. The presence of it during postharvest handling causes the shelf life of the fruits to be shortened. Previous studies have shown that certain mutations on the ethylene receptor genes have successfully prolonged the shelf life of tomato fruits. However, there is a concern that the nutritional and antioxidant content of the produce might be negatively affected. This study aimed to evaluate the impact of Sletr-1 and Sletr-2 mutations on the nutritional and antioxidant levels of tomatoes, apart from its role in delaying the fruit ripening period.

[the_sdg_impact] =>

The World Food Programme reports that there are approximately 800 million people in the world without access to enough food to lead a healthy life. As world leaders, policymakers and the agriculture industry gather to solve this pressing issue, mutation technique on agricultural crops might be a reasonable solution to consider. This study, to lengthen the shelf life of the crops without jeopardizing the nutritional content, could very well align with the UN global goals for sustainable development which addresses world hunger in SDG 2: Zero hunger. With the right set of food safety policy, the aim to end hunger, to achieve food security and improved nutrition, and to promote sustainable agriculture could be accomplished.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0304423819304297?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-28-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Syariful-Mubarok_1469956_1599105721.mp3 [doi] => https://doi.org/10.1016/j.scienta.2019.108546 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Alteration of nutritional and antioxidant level of ethylene receptor tomato mutants, Sletr1-1 and Sletr1-2 [journal_title] => Journal of Scientia Horticulturae [publisher] => Elsevier [year] => October 2019 [subject] => Agronomy; Food Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/0HsIXlU8wcg [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Mutations-alter-postharvest-tomato-shelf-life-and-nutrients.mp4_snapshot_00.01_2021.08.03_23.28.39.png [figures] => ) ) [235] => WP_Post Object ( [ID] => 20103 [post_author] => 1 [post_date] => 2020-10-10 16:03:29 [post_date_gmt] => 2020-10-10 16:03:29 [post_content] => [post_title] => Muscle Fatigue Detector for Spinal Cord Injury Patients During Electrical Simulation [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => muscle-fatigue-detector-for-spinal-cord-injury-patients-during-electrical-simulation [to_ping] => [pinged] => [post_modified] => 2022-07-08 10:46:44 [post_modified_gmt] => 2022-07-08 02:46:44 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20103 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HAMZAID, Nur Azah [researchers_position] => University of Malaya | UM · Department of Biomedical Engineering [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/09/hamzaid.png [researchers_profile] => https://www.researchgate.net/lab/Biomechatronics-and-Neuroprosthetics-Lab-Nur-Azah-Hamzaid [researchers_second_profile] => https://orcid.org/0000-0002-4277-2813 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Functional Electrical Stimulation; Muscle fatigue; Spinal Cord Injury; Mechanomyography; Mel Frequency Cepstral Coefficients (MFCC); Support Vector Machine; Muscle Contraction; Short-time Fourier Transform; Motor Unit; Root Mean Square; Wavelet Transform [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/asd2.png [video] => [the_novelty] =>

The study is about the validation of mechanomyography (MMG) to identify muscle fatigue in neurological conditions such as spinal cord or skeletal muscles injuries. The intended outcome provides insight into the suitability of MMG application as a muscle monitoring tool for spinal cord injury rehabilitation using electrical stimulation. Rehabilitation and physiotherapy practitioners can now effectively optimize patients’ training sessions due to the sensor’s easy accessibility and technique replicability. The promising nature of this method has gained attention from institutions practicing rehabilitation for patients with spinal cord injury worldwide. Clinical trials must be conducted using a larger patient sample with varying conditions, and different mode of training before including it as part of daily training prescription.

[the_background] =>

The existing electrical stimulation training in hospitals do not have reliable feedback about the muscle states and conditions. The identification of a dependable and validated tool to detect muscle fatigue or fatigue point transition is crucial to optimize training protocols and set benchmarks for electrical simulation training. 97.0% accuracy of non-fatigued and fatigued muscle classification proves MMG signals could serve as viable muscle fatigue prediction tool.

[the_sdg_impact] =>

According to the CDC, spinal cord injury (SPI) costs nations like the US, an estimated 9.7 billion dollars each year. The risk of patients with SPI to develop preventable secondary conditions, which could turn life-threatening is higher in low-income countries. In line with the UN’s third Sustainable Development Goal, Good Health and Well-being, researchers believe that personalized rehabilitation training session will help patients with SPI in improving their physical functionality and quality of life. A valid monitoring technique needs to be implemented in rehabilitation protocols to optimize patient safety and enhance training effectiveness since there are existing monitors to-date for muscle state at its best condition.

[article_url] => https://link.springer.com/article/10.1007/s11517-019-01949-4 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/photo-1434682881908-b43d0467b798-768x510-1.jpg [podcast] => [doi] => https://doi.org/10.1007/s11517-019-01949-4 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Mechanomyography-based muscle fatigue detection during electrically elicited cycling in patients with spinal cord injury [journal_title] => Medical & Biological Engineering & Computing [publisher] => Springer Science + Business Media [year] => January 2019 [subject] => Biomedical Engineering; Electrical and Electronic Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [236] => WP_Post Object ( [ID] => 20097 [post_author] => 1 [post_date] => 2020-10-10 16:00:51 [post_date_gmt] => 2020-10-10 16:00:51 [post_content] => [post_title] => Mineralogy of Gold and Silver Telluride [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => mineralogy-of-gold-and-silver-telluride [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:26:57 [post_modified_gmt] => 2021-08-03 15:26:57 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20097 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TINTIN, Euis Yuningsih [researchers_position] => Department of Geology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/26.jpg [researchers_profile] => https://www.researchgate.net/scientific-contributions/2034381417-Euis-Tintin-Yuningsih [researchers_second_profile] => https://orcid.org/0000-0001-7272-8015 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => telluride mineralization; Fluid inclusion; telluride deposition; Telluride minerals; Sulfur fugacity; pliocene; tellurium; Native tellurium; homogenization temperature [graphic_abstract] => [video] => [the_novelty] =>

Minerals are classified as polymetallic ore of fissure filling type in the Late Miocene to Pliocene age. Some tellurides found were native tellurium, hessite, stutzite, petzite, sylvanite, calaverite, tellurobismuthite, tetradymite, Se–bearing tetradymite, tellurantimony, goldfieldite, altaite, coloradoite, tellurite, teineite, and poughite. A primary mineral found was native tellurium, and its initial deposition followed by deposition of tellurides with lower tellurium level showed a decrease in tellurium fugacity. This would indicate a reduction in tellurium activity. Analysis conducted provides evidence of metal and semimetal substitution during the telluride deposition. A decline in sulfur fugacity and temperature and a rise in fugacity of tellurium is seen. A further decline in tellurium fugacity along with the sulfur fugacity caused the deposition of silver, gold, and other tellurides.

[the_background] =>

A southwestern district of Hokkaido provides many mineral resources such as gold, silver, lead, and zinc metals. Gold (Au) and silver (Ag) have been found in tellurides/selenides form in hydrothermal deposits. Previous research proved a correlation between gold-silver and tellurium, but the lack of information on the aqueous tellurium species acting and its property in hydrothermal environments makes it unclear. Sulfur fugacity has been identified to control gold and silver transport and solubility in forming metals. The current study provides mineralogy characterization, compositional variation, and defines telluride mineralization in silver and gold deposits to understand their relationship and coerce the thermochemical environments for ore formation.

[the_sdg_impact] =>

Mining in Japan is very limited as there are limited resources; thus, the mining reserves are small. Conducting more research on Japan’s mining activity will help improve the economy along with the resources. This aligns with Goal 9: Industry, Innovation and Infrastructure of the United Nations’ Sustainable Development Goals. By understanding how mineralogy and geochemistry can be utilized in bringing the mining industry forward, Japan has the ability to thrive in producing minerals with high quality.

[article_url] => https://www.jstage.jst.go.jp/article/jmps/113/6/113_171017/_article/-char/en [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-26-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Euis-Tintin-Yuningsih_1151138_1597644474.mp3 [doi] => https://doi.org/10.2465/jmps.171017 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Ore–microscopy and Geochemistry of Gold–Silver Telluride Mineralization in Southwestern Hokkaido, Japan [journal_title] => Journal of Mineralogical and Petrological Science [publisher] => J-stage [year] => December 2018 [subject] => Geology; Mineralogy ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/DSpZURfwjuE [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Mineralogy-of-Gold-and-Silver-Telluride.mp4_snapshot_00.01_2021.08.03_23.23.52.png [figures] => ) ) [237] => WP_Post Object ( [ID] => 20091 [post_author] => 1 [post_date] => 2020-10-10 15:58:10 [post_date_gmt] => 2020-10-10 15:58:10 [post_content] => [post_title] => Measuring Adherence and Persistence in Multiple Cardiometabolic Medications [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => measuring-adherence-and-persistence-in-multiple-cardiometabolic-medications [to_ping] => [pinged] => [post_modified] => 2021-08-13 16:32:47 [post_modified_gmt] => 2021-08-13 08:32:47 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20091 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ALFIAN, Sofa [researchers_position] => Department of Pharmacology and Pharmacy Clinic, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/33.jpg [researchers_profile] => https://www.researchgate.net/profile/Sofa_Alfian2 [researchers_second_profile] => https://orcid.org/0000-0001-5419-8938 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Prescription data; Multiple cardiometabolic medications; BY-NC; cardiometabolic medications; Medication adherence; multiple medication; Persistence; medication switch; adequate measurement definition [graphic_abstract] => [video] => [the_novelty] =>

The review helps in selecting measures to estimate medication adherence and persistence to multiple cardiometabolic medications from pharmacy data. Five different measures were linked to assess adherence, while three were linked to assess persistence in patients using several medications. Based on the literature reviewed, the ‘‘any medication’’ measure is found to be helpful in monitoring adherence and persistence and to identify patients in need of an intervention. The ‘‘all medication’’ measure is more useful for assessing the effect of interventions. However, a substantial number of studies were flawed because of inconsistent and inadequate description of the methods or how medications switching or additions were dealt with. More attention is needed for providing adequate measurement definitions in reporting on adherence or persistence to multiple medications. Furthermore, future studies are needed to validate the various multiple medications adherence and persistence measures with clinical outcomes.

[the_background] =>

Medication adherence and persistence is associated with being a public health issue because nonadherence can result in poor health outcomes and higher healthcare costs. However, the majority of the measures were of reduced quality, which affects the accuracy and precision of the adherence and persistence rates. The study systematically reviews the techniques to calculate adherence and persistence to various preventive medications from pharmacy data, mainly cardiometabolic medication, and provides guidance on when and why one should choose one measure over another. The study also evaluates if the studies explain the measures used, mainly focusing on adding or changing of medication at drug type or therapeutic stages.

[the_sdg_impact] =>

Adherence is when patients take their prescribed medications while persistence is if they continue with the course of the prescribed medication. It is crucial to identify the adherence and persistence rates among patients as it helps in the treatment process. This aligns with Goal 3: Good Health and Well-being of Sustainable Development Goal. Researchers can be more aware of the measures used for patients using multiple medications and target interventions to enhance the usage of medication. This would, in turn, provide better healthcare options for the patients in the future.

[article_url] => https://www.jclinepi.com/article/S0895-4356(18)30589-4/abstract [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-33-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Sofa-Alfian_1541010_1599479478.mp3 [doi] => https://doi.org/10.1016/j.jclinepi.2018.12.003 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => A systematic review finds inconsistency in the measures used to estimate adherence and persistence to multiple cardiometabolic medications, April 2019, Journal of Clinical Epidemiology. [journal_title] => Journal of Clinical Epidemiology [publisher] => Elsevier [year] => April 2019 [subject] => Medical; Pharmacology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/Z7SVYZqHhrM [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Measuring-adherence-and-persistence-in-multiple-cardiometabolic-medications.mp4_snapshot_00.01_2021.08.13_16.30.19.png [figures] => ) ) [238] => WP_Post Object ( [ID] => 20085 [post_author] => 1 [post_date] => 2020-10-10 15:54:57 [post_date_gmt] => 2020-10-10 15:54:57 [post_content] => [post_title] => Mangosteen Plant Leaf Extract as Potential Anti-influenza Agent [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => mangosteen-plant-leaf-extract-as-potential-anti-influenza-agent [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:58:54 [post_modified_gmt] => 2021-08-03 15:58:54 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20085 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MUCHTARIDI, Muchtaridi [researchers_position] => Department of Pharmaceutical Analysis and Medicinal Chemistry, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/11.jpg [researchers_profile] => https://www.researchgate.net/profile/Muchtaridi_Muchtaridi [researchers_second_profile] => https://orcid.org/0000-0002-6156-8025 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => H1N1; friedolanostan; G. celebica; Garcinia celebica leaves; na inhibition; molecular docking; influenza virus; catechin; hydrophobic; h1n1 na [graphic_abstract] => [video] => [the_novelty] =>

The research discovered catechin compound found in the leaves of Garcinia celebica (a mangosteen plant species) as a potential inhibitor of influenza virus replication. Among the four enzymes isolated from the G. celebica leaves, catechin showed the highest inhibition activity against neuraminidase enzyme (NA) present in influence virus. This study was primarily conducted using an in vitro approach. Though the other 2 enzymes from the extraction displayed strong binding to NA, their inhibition activities were relatively low. This could be due to either the limitations in the assay type used or insufficient observation period before these enzymes even start to react. Nevertheless, the study results suggest exploring catechin in the development of anti-influenza drugs or vaccines, as well as enhancing its inhibition activity through structural modification.

[the_background] =>

Influenza viruses have distinct neuraminidase enzyme (NA) responsible for the infection and replication of the virus in hosts. Though there are several new NA inhibitors developed through synthetic chemistry, researchers are still attempting to identify bioactive compounds in natural products with similar functions. In terms of plant species, there is limited evidence on the anti-viral properties of Garnicia celebica leaves (GCL). Despite past reports on the anti-influenza properties of catechin, there wasn’t any evidence to show the presence of catechin compounds in GCL. Therefore, this study served as proof of the presence of catechin compounds in GCL and highlighted its anti-viral properties against the influenza virus. Also, it provides an opportunity to explore the integration of natural and synthetic compounds in drug discovery processes.

[the_sdg_impact] =>

Late 2017, the World Health Organization (WHO) estimated that a total of 250 000 to 500 000 deaths worldwide were caused by seasonal influenza. In early 2020, the Centres of Disease Control and Prevention (CDC) reported that there had been 13 million influenza illnesses, 120 000 hospitalizations, and 6600 flu-related deaths in the US alone during the influenza season. By exploring the anti-influenza properties of natural products, this study supports the aims of UN SDG 3: Good health and well-being in the development of vaccines and medicines for influenza virus infections.

[article_url] => https://www.mdpi.com/1420-3049/25/4/821 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-11-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Muchtaridi-Muchtaridi_1093260_1597378641.mp3 [doi] => https://doi.org/10.3390/molecules25040821 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Anti-Neuraminidase Bioactives from Manggis Hutan (Garcinia celebica L.) Leaves: Partial Purification and Molecular Characterization [journal_title] => Journal of Molecules [publisher] => MDPI [year] => February 2020 [subject] => Medical; Pharmaceutical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/RSfD3Sw3AfQ [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Mangosteen-plant-leaf-extract-as-potential-anti-influenza-agent.mp4_snapshot_00.01_2021.08.03_23.56.51.png [figures] => ) ) [239] => WP_Post Object ( [ID] => 20079 [post_author] => 1 [post_date] => 2020-10-10 15:52:22 [post_date_gmt] => 2020-10-10 15:52:22 [post_content] => [post_title] => Internet Usage among Visually Impaired Students [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => internet-usage-among-visually-impaired-students [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:35:46 [post_modified_gmt] => 2021-08-03 15:35:46 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20079 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HAFIAR, Hanny [researchers_position] => Department of Corporate Communication, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/8-1.jpg [researchers_profile] => https://www.researchgate.net/directory/profiles [researchers_second_profile] => http://orcid.org/0000-0003-2265-274X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Internet; location identifier; instagram; video download; mobile phone; teenagers; social media; radio streaming; visual impairment; students with visually impaired [graphic_abstract] => [video] => [the_novelty] =>

Teenagers these days, also known as Generation Z, are digital natives born in the world of internet, social networks and advance mobile systems. The internet dominates daily life activities in so many ways, be it communication, education, business dealing, etc. This study primarily focuses on understanding internet usage habits among teenage students with visual disabilities. It was conducted by distributing an open questionnaire to students of Special School for Blind, in Bandung, Indonesia. The data collected showed that visually impaired students do benefit from the internet. Their usage centered significantly around communication and social media platforms with the aid of applications like screen reader. However, there are websites or e-files incompatible to the assisting applications, making it harder for these students to access to all information.

[the_background] =>

In this digital era, the majority of information is accessed through the internet in the form of text and images. This poses a challenge for those with visual impairment, especially when it comes to equality in information consumption. Apart from knowledge-seeking, students with visual disabilities also leverage the internet to communicate and socialize like every other normal person. Though there are tools invented to assist them in using the internet, a few glitches are still observed, restricting the accessibility of the content. Thus, unconsciously making these students feel socially excluded and potentially create a digital divide. Therefore, this study suggests to the developers of communication technology to build products that could accommodate the special needs people.

[the_sdg_impact] =>

The recent WHO report states that there are approximately 2.2 billion people with visual impairment or blindness globally. This makes up almost one-third of the current world population. With Industry 4.0 and the internet evolving rapidly, it is only fair to improve communication technology and information accessibility to feed the needs of those with visual difficulty, to promote inclusivity. As envisioned in the UN SDG 10: Reduced inequalities, the findings of this study prove that all technological advancement hereafter should take into consideration the challenges faced by those visually impaired.

[article_url] => https://online-journals.org/index.php/i-jet/article/view/10057 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-8-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Hanny-Hafiar_1092958_1597377222.mp3 [doi] => https://doi.org/10.3991/ijet.v14i10.10057 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Internet Utilization by the Students with Visual Impairment Disabilities [journal_title] => International Journal of Emerging Technologies in Learning [publisher] => iJET [year] => May 2019 [subject] => Corporate Communication ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/67WDYD4hxYQ [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Internet-usage-among-visually-impaired-students.mp4_snapshot_00.01_2021.08.03_23.33.39.png [figures] => ) ) [240] => WP_Post Object ( [ID] => 20071 [post_author] => 1 [post_date] => 2020-10-10 15:49:30 [post_date_gmt] => 2020-10-10 15:49:30 [post_content] => [post_title] => Information Representation and Its Influence of Job Efficiency [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => information-representation-and-its-influence-of-job-efficiency [to_ping] => [pinged] => [post_modified] => 2021-07-16 12:02:14 [post_modified_gmt] => 2021-07-16 04:02:14 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20071 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => RITCHI, Hamzah [researchers_position] => Department of Accounting, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/2-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Hamzah_Ritchi [researchers_second_profile] => https://orcid.org/0000-0002-9374-9357 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Procure-to-pay process; textual representation; BPMN; process model; Goods receipt handling process; representation format; task type; Business Process Model and Notation; visual representation; process representation [graphic_abstract] => [video] => [the_novelty] =>

This research established a positive correlation between the representation format of business process models and their influence on task performance. With that said, there isn’t one format that is superior to the other. Instead, the performance and representation format are equally effective when matched appropriately based on the nature of the task. The findings showed that for tasks involving search or recognition or inference, both experts and novices would perform efficiently if the business process models were visual. On the other hand, for tasks involving problem-solving by experts or recollection, the textual models will be better suited. The research could be further expanded to other fields, such as software engineering and information systems research.

[the_background] =>

Business process analysis is an essential part of the risk assessment procedures and audit methodology. With the right models, the quality of business operations could be improved, and the process is made more time-efficient as well as cost-effective. To date, there was no substantial evidence on the pros and cons of visual and textual representation format of business process analysis was compared to account for efficiency. Therefore, this study aims to distinguish between the nature of tasks based on textual/visual and deep/surface learning dimensions to evaluate the effectiveness of the task accordingly.

[the_sdg_impact] =>

The importance of information representation has long been established in Accounting Information Systems (AIS). Effective information representation would improve the productivity of the system and have potential effects on the decision-making process. The outcome of this study provides new insights into identifying the most suitable format for information representation for tasks of different nature. It is also in line with the idea of the United Nations’ SDG 8: Decent work and economic growth to promote sustained, inclusive, full and productive employment and decent work for all.

[article_url] => https://meridian.allenpress.com/jis/article-abstract/34/1/167/10586/The-Influence-of-Business-Process-Representation?redirectedFrom=fulltext [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-1-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Hamzah-Ritchi_1091668_1597370143.mp3 [doi] => https://doi.org/10.2308/isys-52385 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The influence of business process representation on performance of different task types [journal_title] => Journal of Information Systems [publisher] => American Accounting Association (AAA) [year] => November 2018 [subject] => Accounting ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/AcYnaaxrVj0 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Information-representation-and-its-influence-of-job-efficiency.mp4_snapshot_00.01_2021.07.16_11.59.56.png ) ) [241] => WP_Post Object ( [ID] => 20065 [post_author] => 1 [post_date] => 2020-10-10 15:46:20 [post_date_gmt] => 2020-10-10 15:46:20 [post_content] => [post_title] => Including Cultural Equality into the Nation’s Legal System [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => including-cultural-equality-into-the-nations-legal-system [to_ping] => [pinged] => [post_modified] => 2021-07-16 11:16:24 [post_modified_gmt] => 2021-07-16 03:16:24 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20065 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PALAR, Miranda Risang Ayu [researchers_position] => Department of Intellectual Property, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/3-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Miranda_Palar [researchers_second_profile] => https://orcid.org/0000-0001-9579-0495 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Trade-Related Aspects of Intellectual Property Rights; Universal Declaration of Human Rights; cultural equality; public order; World Trade Organization; Integrated Circuit Lay-Out; ten principles; buddha bar; indonesia; intellectual property rights [graphic_abstract] => [video] => [the_novelty] =>

This study demonstrated how the Indonesian legal system evolved by adopting the community belief system and cultural practices. Such was observed by reviewing the verdicts in a number of local cases that aligned between the Indonesian Intellectual Property Rights (IPRs), its original constitute, and cultural equality. The outcome of the review also emphasized the universal principles of the non-aligned framework which were capable of accommodating the nation’s diverse cultural practices without violating the Trade Related Aspects of Intellectual Property Rights (TRIPS) agreement of the World Trade Organization (WTO).

[the_background] =>

Indonesia has shown that the Ten Principles of Bandung framework that came from the non-aligned movement has shaped the evolution of Indonesia IPRs. The alignment between these two was only possible as the basis of the principles was centered around the universal principles of humanity. Therefore, by referring to the Indonesian experience, this study aims to inspire other nations to include the cultural factor when attempting to harmonize their IPRs with the TRIPS agreement.

[the_sdg_impact] =>

When equality is of concern, the subject matter is not restricted to just freedom, gender, and disability, but also in terms of culture and religion. Aligned with the United Nations’ SDG 10: Reduced inequality, this study highlights effective ways to shape a nation’s legal system by taking into consideration both international standards and the diverse cultural belief system. With that, lawmakers would be able to ensure equal opportunity is given to defend the rights of religious and spiritual minorities by promoting appropriate legislations.

[article_url] => https://www.tandfonline.com/doi/abs/10.1080/20421338.2019.1588510 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-2-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Miranda-Risang-Ayu-Palar_1092062_1597372066.mp3 [doi] => https://doi.org/10.1080/20421338.2019.1588510 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Universalization of Indonesian cultural and scientific regulations [journal_title] => African Journal of Science, Technology, Innovation, and Development [publisher] => Taylor & Francis Online [year] => May 2019 [subject] => Intellectual Property ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/3tIZPfEkb8E [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Including-cultural-equality-into-the-nations-legal-system.mp4_snapshot_00.00_2021.07.16_11.13.56.png ) ) [242] => WP_Post Object ( [ID] => 20060 [post_author] => 1 [post_date] => 2020-10-10 15:43:30 [post_date_gmt] => 2020-10-10 15:43:30 [post_content] => [post_title] => In Silico Analysis of Novel Peptides as Potential Anti-dengue Therapeutic [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => in-silico-analysis-of-novel-peptides-as-potential-anti-dengue-therapeutic [to_ping] => [pinged] => [post_modified] => 2021-07-19 13:22:09 [post_modified_gmt] => 2021-07-19 05:22:09 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20060 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => OTHMAN, Rozana [researchers_position] => University of Malaya | UM · Department of Pharmacy [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/Rozana_Othman-150x150-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Rozana_Othman [researchers_second_profile] => https://orcid.org/0000-0002-8260-9252 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Peptide; Molecular Dynamics Simulation; Envelope Protein; Docking; Free Energy of Binding; Dengue; Generalized Born; Molecular Mechanics-Poisson Boltzmann Surface Area; Poisson Boltzmann;Electrostatic; Molecular Mechanics; Molecular Mechanics Generalized Born Surface Area; Free Energy; Amino Acid [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/rozana.png [video] => [the_novelty] =>

This study suggests DN58opt, a novel synthetic peptide, as one of the effective inhibitors of dengue virus (DENV) entry into target cells. This study is supported by the previously established role of E-glycoprotein in the DENV attachment to host cell receptors and target cells entry. By describing the binding mechanisms of the complexes to the target proteins and understanding important structural information, new compounds with potential anti-dengue therapeutic could be designed. Implementation of this study will bring changes in the treatment of diseases and has the ability to influence pharmaceutical companies, including researchers in the drug development field.

[the_background] =>

Local and global statistics reveal an alarming rise in annual dengue infection cases. Unfortunately, there is a lack of drugs and vaccines available in treating illnesses related to dengue infections. While existing treatment approach is symptomatic only and carries adverse side effects. Hence, continuous efforts should be engaged to address this problem, in particular, to develop drugs as therapeutics. This study also proves that computational tools expedite the early stage of the drug development process by leveraging on the information which is yet to be made available from lab experiments. The availability of big data of chemicals should be exploited for the benefit of humankind.

[the_sdg_impact] =>

Computational drug discovery and design are gaining popularity among researchers and pharmaceutical companies due to its promising contribution in understanding molecular structures as well as biomedical applications. As the process of designing and discovering new therapeutics are on-going processes, new information gathered will eventually be translated into better solutions or treatments for various ailments. By doing so, this study aims to achieve the UN’s third Sustainable Development Goal by ensuring healthy lives and promoting well-being for all at all ages.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S1093326316304946 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/photo-1554475901-4538ddfbccc2-768x511-1.jpg [podcast] => [doi] => https://doi.org/10.1016/j.jmgm.2017.03.010 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Conformational and energy evaluations of novel peptides binding to dengue virus envelope protein [journal_title] => Journal of Molecular Graphics and Modelling [publisher] => Elsevier [year] => June 2017 [subject] => Theoretical and Computational Chemistry ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [243] => WP_Post Object ( [ID] => 20056 [post_author] => 1 [post_date] => 2020-10-10 15:40:31 [post_date_gmt] => 2020-10-10 15:40:31 [post_content] => [post_title] => Formation of Cancer: The Biological Pathway [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => formation-of-cancer-the-biological-pathway [to_ping] => [pinged] => [post_modified] => 2022-08-08 12:46:15 [post_modified_gmt] => 2022-08-08 04:46:15 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20056 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/r1-1.png [researchers_profile] => https://www.researchgate.net/profile/Mien_Chie_Hung [researchers_second_profile] => https://orcid.org/0000-0003-4317-4740 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Cancer biology; Immunotherapy; Immune Checkpoint; PD-1; Post-translational Modification [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/Picture1.png [video] => [the_novelty] =>

This research highlighted the role of the PCK 1 enzymatic pathway in cancer cell growth. An in vivo study (using mice) was conducted to understand the pathway leading to the development of hepatocellular carcinoma (HCC), commonly known as liver cancer. The number of cancer cells is found to increase rapidly when the cells speed up its metabolic formation of fat, lipogenesis. This process is initiated by the activation of SREBPs, the binding proteins in cells. The activity of SREBPs can be inhibited by a complex consisting of INSIG proteins, SCAP, and sterols. The research demonstrated that AKT in HCC cells when activated by oncogenes, creates a chain of biochemical reactions starting with the PCK 1 enzyme. The alteration of PCK1 causes the binding of sterols to INSIG to reduce and disrupts the interaction between INSIG and SCAP. As a result, the complex that inhibits SREBP is incomplete, leaving only SCAP to bind to the SREBPs. As the SREBPs move on to the Golgi apparatus, it will lead to an increase in the formation of lipogenesis-related genes and tumor cells, eventually leading to HCC in mice.

[the_background] =>

In the cancer cell development pathways, interactions between enzymes and proteins play a crucial role. This research attempts to highlight the interaction between INSIG proteins and the SREBP-SCAP complex independent of sterols that potentially triggers tumor cell growth. The findings outlined a detailed pathway led by the activated AKT altering the PCK 1 enzyme, which led to increased tumor cell growth. By understanding the pathway, the opportunity for more refined research directions for various cancer therapies can be explored.

[the_sdg_impact] =>

The disadvantages of chemotherapy are widely known and feared by many. In recent years, alternative treatment methods like immunotherapy, molecular therapy, etc., have been actively explored. The ultimate purpose of this research is to learn the biological pathways of cancer formation to prevent or cure cancer effectively through such therapeutic methods. This aligns perfectly with “Goal 3: Good Health and Well-Being” of the United Nations’ Sustainable Development Goals. One of the targets to achieve this goal is to reduce premature mortality from non-communicable diseases by one third through prevention and treatment. With discoveries providing a molecular-level understanding of the tumor development, chances of early-stage detection or treatment are improved. Consequently, people will stand a better chance to prevent or battle cancer.

[article_url] => https://www.nature.com/articles/s41586-020-2183-2#article-info [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/pck1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Formation-of-Cancer_3197906_1606964305.mp3 [doi] => https://doi.org/10.1038/s41586-020-2183-2 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis [journal_title] => Nature [publisher] => Springer Nature [year] => 2020 [subject] => Cancer Biology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/UD3u656hdLI [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-23.jpg [figures] => ) ) [244] => WP_Post Object ( [ID] => 20052 [post_author] => 1 [post_date] => 2020-10-10 15:37:28 [post_date_gmt] => 2020-10-10 15:37:28 [post_content] => [post_title] => Genetic Characteristics of Inherited Shortness in Human [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => genetic-characteristics-of-inherited-shortness-in-human [to_ping] => [pinged] => [post_modified] => 2021-05-11 15:25:32 [post_modified_gmt] => 2021-05-11 07:25:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20052 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => TSAI, Fuu-Jen (蔡輔仁) [researchers_position] => Department of Research and Genetic Medicine, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/r4.png [researchers_profile] => https://www.researchgate.net/profile/Fuu-Jen_Tsai3 [researchers_second_profile] => http://orcid.org/0000-0002-1373-245X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Familial; Short Stature; Polygenic Trait; Human Height; Han Chinese Ancestry; GWAS [graphic_abstract] => [video] => https://www.youtube.com/embed/3C1azY7cxS4 [the_novelty] =>

Besides identifying the genetic profile of Familial Short Stature (FSS), also known as the inherited shortness trait, this study aimed to predict the probability of this trait influencing the height pattern in the general population using polygenic risk predisposition score. Being the first comprehensive FSS genetic profile, 10 novel genetic single-nucleotide polymorphisms (SNPs) and 9 reported genome-wide association study (GWAS) human height-related SNPs associated with FSS risk were identified. The 10 novel SNPs are genetic-markers (served as a polygenic risk predisposition score) for FSS risk prediction. The molecular influence, which involves hormone and bone metabolisms, was explained in relation to the FSS genetic traits and height-reduction effect.

[the_background] =>

Familial Short Stature (FSS) is commonly associated with a family history of shortness due to genetic factors. The body height of an individual highly depends on bone metabolism. This study had found the genetic characteristics of FSS, along with their bone metabolic that causes shortness. Such findings contribute significantly to a better understanding of FSS genetically. Although most traits are complex and involve numerous genes, such a study is necessary for guiding and inspiring any relevant research in the future. To a certain extent, this can be one of the starting points to overcome FSS from the perspective of human genetic engineering.

[the_sdg_impact] =>

The height of humans has always been a primary criterion of some occupations. Often, it is associated with the level of physical attractiveness. Some studies proved a large number of short people, regardless of their gender, are victims of stigmatization and prejudice. Thus, exposing them to the risk of psychological stress and societal pressure, eventually affecting their quality of life. The results of this study, in line with “Goal 3: Good Health and Well-Being” of the UN’s Sustainable Development Goals (SDG), could serve as a stepping stone for future researches to either alter the negative perception towards shorter people through education or to expand genetic engineering to overcome shortness.

[article_url] => https://academic.oup.com/jcem/article-abstract/105/6/1801/5805154?redirectedFrom=fulltext [main_image] => [podcast] => [doi] => https://doi.org/10.1210/clinem/dgaa131 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Genetic Architecture Associated with Familial Short Stature [journal_title] => Journal of Clinical Endocrinology & Metabolism [publisher] => Oxford Academic [year] => March 2020 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-38.jpg ) ) [245] => WP_Post Object ( [ID] => 20046 [post_author] => 1 [post_date] => 2020-10-10 15:34:33 [post_date_gmt] => 2020-10-10 15:34:33 [post_content] => [post_title] => Guava and Vitamin C Supplements Could Prevent Gum Disease [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => guava-and-vitamin-c-supplements-could-prevent-gum-disease [to_ping] => [pinged] => [post_modified] => 2021-05-12 10:45:35 [post_modified_gmt] => 2021-05-12 02:45:35 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20046 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => AMALIYA, Amaliya [researchers_position] => Department of Periodontology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/45.jpg [researchers_profile] => https://www.researchgate.net/profile/Amaliya_Amaliya [researchers_second_profile] => https://orcid.org/0000-0002-9164-0542 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => oral hygiene; supplementation; vitamin C; Plaque Index; gingival inflammation; control group; Gingival Index; vitamin c supplementation; experimental gingivitis; gingivitis [graphic_abstract] => [video] => [the_novelty] =>

To guide the public in taking care of their oral health, this study has reported that consumption of either 200 g guava/day or 200 mg synthetic vitamin C/day has a preventive effect on the development of gingivitis. 48 non-smoking students were selected as the subjects of the study in which the students were randomly assigned to three groups supplemented daily with either 200 g guava, 200 mg synthetic vitamin C or water for 14 days. Future studies can be conducted by extending the experiment period to make firm conclusions regarding the greater inflammatory preventive effect of guava compared to vitamin C alone.

[the_background] =>

Past studies had reported that the degree of gingival inflammation is directly related to plasma vitamin C and that gingival bleeding can be reduced by vitamin C supplementation, either by diet or supplements. Guava fruit is well-known for its anti-inflammatory, antimicrobial, antioxidant, antidiarrheal and antimutagenic properties. Besides that, guava fruit contains almost four times the amount of vitamin C compared to oranges. Hence, this research was conducted to study the effect of guava fruit and synthetic vitamin C on the development of gingival inflammation during experimental gingivitis.

[the_sdg_impact] =>

WHO states that severe periodontal diseases are estimated to affect nearly 10% of the global population. Since gingivitis is one of the leading root causes of periodontal diseases, knowing how to prevent it would maintain one’s oral health. The findings from this study have clearly outlined that consuming guava fruits is a feasible way to reduce the development of gingivitis. Since the UN is aiming to support the research and development of medicines, the findings of this study are important to realize Goal 3: Good Health and Well-being of UNSDG.

[article_url] => https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.12922 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-45-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Amaliya-Amaliya_1682121_1600142901.mp3 [doi] => https://doi.org/10.1111/jcpe.12922 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Effect of guava and vitamin C supplementation on experimental gingivitis: A randomized clinical trial [journal_title] => Journal of Clinical Periodontology [publisher] => Wiley [year] => May 2018 [subject] => Medical; Periodontology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/IL1iEiqju6o [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/47-w-subs-music.mp4_snapshot_00.01_2021.05.12_10.44.13.jpg ) ) [246] => WP_Post Object ( [ID] => 20040 [post_author] => 1 [post_date] => 2020-10-10 15:32:12 [post_date_gmt] => 2020-10-10 15:32:12 [post_content] => [post_title] => Heat Treatment Improves Properties of Banana Starch [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => heat-treatment-improves-properties-of-banana-starch [to_ping] => [pinged] => [post_modified] => 2021-05-22 23:03:35 [post_modified_gmt] => 2021-05-22 15:03:35 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20040 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CAHYANA, Yana [researchers_position] => Department of Food Technology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/15.jpg [researchers_profile] => https://www.researchgate.net/profile/Yana_Cahyana [researchers_second_profile] => https://orcid.org/0000-0002-8615-9498 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => slowly digestible starch;heat moisture treatment; dual retrogradation;native banana flour; thermal treatment; X-ray diffraction; resistant starch; Digestibility; Banana; banana flour [graphic_abstract] => [video] => [the_novelty] =>

Intending to improve the properties of banana starch, this study has reported the effect of heat moisture treatment (HMT), annealing (ANN), and dual retrogradation (DR) on the functional properties, pasting properties, and digestibility of starch components of banana flour. HMT and ANN increased the relative crystallinity, but DR decreased it. HMT and DR altered the XRD patterns, while ANN did not cause any change. These effects proved that the properties of starch could be improved for its application in the food industry. In future studies, the parameters of the treatment may be optimized to enhance the value of banana starch further.

[the_background] =>

There are limitations in native starch application because of its poor thermal, shear, and acid stability, as well as the high rate and extent of retrogradation during storage. In order to enhance such properties, physical modification is preferred rather than chemical or enzymatic modification due to the absence of residues of any chemical reagents. Apart from the conflicting conclusions drawn by past reviews, a detailed study comparing different thermal treatment effects on banana flour properties has not been reported. Hence, it is necessary to examine the effects of the three commonly applied thermal modifications, i.e., HMT, ANN and DR in a simultaneous study. The outcome of this study sets a clear direction for the food industry on improving the properties of banana starch.

[the_sdg_impact] =>

Although the consumption of banana flour is much lower than that of wheat flour, the global consumption of banana flour is forecast to surpass 400,000 MT by the end of 2027 (Source: Future Market Insights). Looking at the growing market demand, it is important to explore ways to improve the properties of banana flour. Aligned with the UN’s target to achieve the sustainable management and efficient use of natural resources by 2030, the output of this study shows high potential in realizing the Goal 12: Responsible Consumption and Production of UN’s Sustainable Development Goals (SDG).

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0308814618315693?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-15-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Yana-Cahyana_1093730_1597380861-1.mp3 [doi] => https://doi.org/10.1016/j.foodchem.2018.09.004 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The effect of different thermal modifications on slowly digestible starch and physicochemical properties of green banana flour (Musa acuminata colla) [journal_title] => Journal of Food Chemistry [publisher] => Elsevier [year] => February 2019 [subject] => Food Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/9jzYepusT4c [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-4.jpg ) ) [247] => WP_Post Object ( [ID] => 20035 [post_author] => 1 [post_date] => 2020-10-10 15:26:23 [post_date_gmt] => 2020-10-10 15:26:23 [post_content] => [post_title] => High Fibre Diet for Weight Loss [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => high-fibre-diet-for-weight-loss-2 [to_ping] => [pinged] => [post_modified] => 2021-07-19 15:49:17 [post_modified_gmt] => 2021-07-19 07:49:17 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20035 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KN, Geetha [researchers_position] => Department of Agronomy, University of Agriculture Science, India [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/Geetha-K.jpg [researchers_profile] => https://www.researchgate.net/profile/DrKN_Geetha [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Obesity; high fibre food mix; waist circumference; body mass index; dietary intervention; biochemical parameter; body weight; hip circumference; Dietary fibre; Fasting Blood Sugar [graphic_abstract] => [video] => [the_novelty] =>

By altering the nutritional composition of meals consumed by obese rural women, this study recorded positive impacts on weight control measures and body metabolic functions. Researchers developed a low fat, high protein and fibre food mix using locally available ingredients, such as millets, legumes, vegetables and oilseeds. At the end of the dietary implementation, significant reductions in total cholesterol, LDL, and Fasting Blood Sugar (FBS) levels were recorded. The increased proportion of soluble and insoluble dietary fibre in the developed meal plan also reduced the quantity of food intake among the subjects; thus, contributing to their weight loss. This study proved that modification of daily diet, by including more fibre, not only helps in weight loss, but also aids in preventing secondary complications.

[the_background] =>

The increasingly convenient lifestyle has altered the daily routine and activities of many. More people are leading a sedentary lifestyle, lacking proper physical activities, and consuming unhealthy meals. As a result, a rise in the statistics of people with obesity, diabetes, high cholesterol, etc., are observable. From a nutritional perspective, dietary fibre plays an important role in maintaining a healthy diet, especially in managing bodyweight issues. Therefore, this study aims to develop a high fibre-based meal using locally available ingredients to control weight and improve blood test results.

[the_sdg_impact] =>

More than 1.9 billion adults, aged 18 years and above, were reported to be overweight by the World Health Organization (WHO) in 2016. It was also reported that close to 400 million children and adolescents were either overweight or obese in 2019. Such a scenario gave way to numerous non-communicable diseases, which led to decreased quality of life, or worse, premature fatality. This study initiates dietary interventions as part of a solution to this global concern. By providing data on successful weight control and improved body metabolic functions due to diet plan alteration, this study contributes to the realization of UN SDG 3: Good health and well-being.

[article_url] => https://www.alliedacademies.org/articles/effect-of-high-fibre-food-mix-on-lipid-profile-and-body-weight-in-obesesubjects-11469.html [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/diet2-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Geetha_1028662_1597115527.mp3 [doi] => https://doi.org/10.35841/biomedicalresearch.30-19-257 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Effect of high fibre food mix on lipid profile and body weight in obese subjects [journal_title] => Biomedical Research [publisher] => Allied Academics [year] => May 2019 [subject] => Agronomy; Biomedical ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [248] => WP_Post Object ( [ID] => 20029 [post_author] => 1 [post_date] => 2020-10-10 15:23:47 [post_date_gmt] => 2020-10-10 15:23:47 [post_content] => [post_title] => Higher Risk of Bone fracture among People Living with HIV [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => higher-risk-of-bone-fracture-among-people-living-with-hiv [to_ping] => [pinged] => [post_modified] => 2021-05-22 22:35:34 [post_modified_gmt] => 2021-05-22 14:35:34 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20029 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PRAMUKTI, Iqbal [researchers_position] => Department of Nursing, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/13.jpg [researchers_profile] => https://www.researchgate.net/profile/Iqbal_Pramukti [researchers_second_profile] => https://orcid.org/0000-0002-0645-0534 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => risk factor; Joanna Briggs Institute; systematic review; general population; incidence rate; bone fracture; osteoporosis; highly active antiretroviral therapy; bone mineral density; people living with HIV [graphic_abstract] => [video] => [the_novelty] =>

This study revealed a higher prevalence and incidence rate of bone fracture among people living with HIV (PLWH) compared to the general population. Besides that, it also reported that smoking, older age, osteoporosis, and HIV/HCV coinfection are the significant risk factors for bone fracture among PLWH. The investigation had applied various statistical analysis methods on the relevant researches published up to August 2019. PubMed, Cochrane Library, CINAHL with Full Text, and Medline databases were used as the sources of information for this investigation. With a more accurate and complete report, the healthcare providers will be able to provide better services for the health benefits of PLWH.

[the_background] =>

Among the PLWH, a reliable prevention and treatment program is needed to minimize the consequence of bone loss and morbidity associated with bone fractures. Such a program can be developed and improved by identifying the prevalence, incidence, and risk factors for fractures among PLWH. However, the prevalence and incidence rate data reported by the past studies were inconsistent, mainly due to the difference in methodology. Hence, by reviewing the past studies, this study conducted a systematic review and meta-regression to determine the pooled prevalence, incidence rate of fracture and fracture risk factors among PLWH. Other than contributing to the healthcare sector, these findings serve as an important addition to the literature for other future studies to be carried out more successfully.

[the_sdg_impact] =>

According to WHO, 38 million people were living with HIV globally at end-2019. Thus, accurate pooled prevalence, the incidence rate of fracture and fracture risk factors among the PLWH are important to maintain the health and well-being of the PLWH. While the United Nations aims to strengthen the capacity of all countries for the management of national and global health risks, this study provides meaningful data to achieve Goal 3: Good Health & Well-Being of UN’s Sustainable Development Goals (SDG).

[article_url] => https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233501 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-13-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Iqbal-Pramukti_1093498_1597379554.mp3 [doi] => https://doi.org/10.1371/journal.pone.0233501 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Bone fracture among people living with HIV: A systematic review and meta-regression of prevalence, incidence, and risk factors [journal_title] => PLOS One [publisher] => PLOS [year] => June 2020 [subject] => Medical; Nursing ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/z46FQm4l8tw [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-8.jpg ) ) [249] => WP_Post Object ( [ID] => 20022 [post_author] => 1 [post_date] => 2020-10-10 15:20:59 [post_date_gmt] => 2020-10-10 15:20:59 [post_content] => [post_title] => Higher-Dose Oral Rifampin Reduces the Mortality Rate of Patients with Tuberculous Meningitis [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => higher-dose-oral-rifampin-reduces-the-mortality-rate-of-patients-with-tuberculous-meningitis [to_ping] => [pinged] => [post_modified] => 2021-07-03 14:40:12 [post_modified_gmt] => 2021-07-03 06:40:12 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20022 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => DIAN, Sofiati [researchers_position] => Department of Neurology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/38.jpg [researchers_profile] => https://www.researchgate.net/profile/Sofiati_Dian [researchers_second_profile] => https://orcid.org/0000-0001-9909-4171 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => cerebrospinal fluid; rifampin; tuberculosis; adverse event; oral rifampin; tuberculous meningitis; AUC0–; kg group; meningitis [graphic_abstract] => [video] => [the_novelty] =>

As an effort to help patients with tuberculous meningitis (TBM), this study reported that high-dose oral rifampin (up to 30 mg/kg) was save and potentially beneficial to improve survival of patients with (TBM). Sixty adult TBM patients were assigned to 10, 20, and 30 mg/kg oral rifampicin combined with other TB drugs for 30 days. To ensure the well-being of the TBM patients who survived due to the higher dosage, the research team suggested evaluated the efficacy of this dose in the next phase and larger study.

[the_background] =>

The reported high mortality rate in TBM patients with resistance to rifampin had proven that rifampin is an important tuberculosis (TB) drug. However, rifampin has low penetration ability to the brain, site of infection in TBM. Doses up to 20 mg/kg orally still inadequate to reach the target plasma concentration that give survival benefit. Oral rifampin is affordable and developing new drugs takes too long to be useful for treating TB and TBM. Therefore, it is necessary to make the best possible use of existing drugs, i.e., rifampin. In order to address these hurdles, this study was performed to evaluate the pharmacokinetics, safety/tolerability, and efficacy of higher (up to 30 mg/ kg) doses of oral rifampin as a TBM treatment. The promising result obtained using higher dose oral rifampin is a significant improvement in the treatment of TB and TBM. Such findings implied that there could also be other, more effective methods of using rifampin for such treatment.

[the_sdg_impact] =>

In 2018, the WHO estimated 10 million new TB cases worldwide, and there were 205 000 child deaths due to TB. Since TB is one of the top 10 causes of death, the prevention and treatment of TB should be one of the top priorities in medical science. As the UN aims to end the epidemics like tuberculosis by 2030, the objective of this study is very well-aligned with Goal 3: Good Health and Well-being of the UNSDG.

[article_url] => https://aac.asm.org/content/62/12/e01014-18 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-38-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Sofiati-Dian_1615112_1599797252.mp3 [doi] => https://doi.org/10.1128/AAC.01014-18 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Double-Blind, Randomized, Placebo-Controlled Phase II Dose-Finding Study To Evaluate High-Dose Rifampin for Tuberculous Meningitis [journal_title] => Journal Antimicrobial Agents and Chemotherapy [publisher] => American Society for Microbiology [year] => November 2018 [subject] => Microbiology; Neurology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/89Z31ihIPEM [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-5.jpg ) ) [250] => WP_Post Object ( [ID] => 20016 [post_author] => 1 [post_date] => 2020-10-10 15:18:15 [post_date_gmt] => 2020-10-10 15:18:15 [post_content] => [post_title] => How to Improve Medication Adherence among Tuberculosis Patients? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => how-to-improve-medication-adherence-among-tuberculosis-patients [to_ping] => [pinged] => [post_modified] => 2021-07-19 11:48:33 [post_modified_gmt] => 2021-07-19 03:48:33 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20016 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PRADIPTA, Ivan [researchers_position] => Department of Pharmacology and Clinical Pharmacy, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/35-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Ivan_Pradipta [researchers_second_profile] => https://orcid.org/0000-0002-7151-0783 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => LTBI; tuberculosis; ltbi patient; synthesis; World Health Organization; active tb patient; treatment completion; secondary outcome; tb patient; sms reminder [graphic_abstract] => [video] => [the_novelty] =>

The findings of this study revealed that some intervention improves medication adherence among Tuberculosis (TB) patients. The study was conducted by analyzing previous articles on TB treatment and carrying out randomized studies to evaluate the effectiveness of the various interventions. Observation of healthcare professionals on tuberculosis (TB) patients during the consumption of the medication is the most common intervention for most TB patients. Other intervention methods, such as Short Message Service (SMS) reminder, health education on TB, behavioral counseling, and shorter regimen, were found to improve medication adherence. However, the various effect of the intervention was identified across the studies. It shows that individual intervention is needed as an impact of the differences in adherence problems among TB patients. Since multiple factors can cause medication adherence, future research on intervention studies should be carried out based on individual problems. Moreover, the intervention should be concentrated on the effectiveness of personalized TB medication adherence programs.

[the_background] =>

The degree in which a patient takes medication as prescribed by the doctors, medication adherence, can be improved through an intervention that results in enhanced effectiveness of treatment on TB patients. So is the goal of this study. The existing studies on TB medication adherence demonstrated various effects, and some provided insufficient information regarding the interventions and their impacts on medication adherence. As a result, articles focusing on possible interventions and medication adherence should be reviewed in future studies. By doing so, more accurate results could be generated, and interventions that can aid in improving the treatment of TB patients could be determined.

[the_sdg_impact] =>

Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis infection. It is one of the leading causes of death, as nearly 1.5 million people died due to TB, as reported by the World Health Organization in 2018. Researchers are carrying out various studies to determine an effective treatment for TB to reduce the deaths and infections of Mycobacterium tuberculosis in the future. The UN’s Sustainable Development Goals (SDG) addressed by this study is “Goal 3: Good Health and Well-Being”. Possible interventions to enhance the effectiveness of existing TB treatments is substantial to attain the “The End TB Strategy” and produce a solution for multidrug-resistant TB, which is a public health crisis. Further studies based on this study are essential in developing new strategies or enhancing existing strategies to treat TB.

[article_url] => https://www.nature.com/articles/s41533-020-0179-x [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-35-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Ivan-Pradipta_1555450_1599548476.mp3 [doi] => https://doi.org/10.1038/s41533-020-0179-x [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Interventions to improve medication adherence in tuberculosis patients: a systematic review of randomized controlled studies [journal_title] => Nature Primary Care Respiratory Medicine [publisher] => Springer Nature [year] => May 2020 [subject] => Medical; Pharmacology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/DTTdyGM4ZPE [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-10.jpg ) ) [251] => WP_Post Object ( [ID] => 20009 [post_author] => 1 [post_date] => 2020-10-10 15:12:47 [post_date_gmt] => 2020-10-10 15:12:47 [post_content] => [post_title] => How to Predict Tectonic Activity? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => how-to-predict-tectonic-activity [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:33:32 [post_modified_gmt] => 2021-08-03 15:33:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20009 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SUKIYAH, Emi [researchers_position] => Department of Geological Science, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/21.jpg [researchers_profile] => https://www.researchgate.net/profile/Emi_Sukiyah [researchers_second_profile] => http://orcid.org/0000-0002-9975-363X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => tectonic activity; Jatigede Reservoir; drainage basin; Cimanuk; upper cimanuk drainage basin; sinuosity of mountain front; bifurcation ratio; drainage density; cimanuk drainage basin [graphic_abstract] => [video] => [the_novelty] =>

This study provided evidence that the degree of tectonic activity occurring in the Cimanuk drainage basin, where the reservoir is, can be identified by studying the area’s surface and geographical structures. It was observed that in areas controlled by active faults, drainage basins have relatively higher density values compared to the more stable areas. Apart from that, the drainage basin patterns can also be used as an indicator of active tectonics. Some of the other landscape changes visible were the lineament of the ridge, valley and stream, angle of river curvature, etc. This study suggested continuous monitoring and engineering due to the existence of a reservoir to minimize disaster risk if any faults in the vicinity are reactivated.

[the_background] =>

The Cimanuk drainage basin was selected as a strategic study area due to the construction of a reservoir in this region. Understanding the degree of tectonic activity in this region allows easy prediction of potential disasters, like landslides, could occur. The geomorphological analysis also provides information on the extent of damage the area has experienced, thus, allowing proper monitoring and restoration processes to be implemented.

[the_sdg_impact] =>

Indonesia is known for volcanic eruptions and earthquake vulnerability due to its location between 3 active tectonic plates. In alignment with the aim of UN SDG 11: Sustainable cities and communities, to achieve reduced death tolls and number of people affected by natural disasters, this study could potentially be used in developing early warning systems. This would be particularly useful in regions with similar geographical makeup.

[article_url] => http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=5441 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-21-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Emi-Sukiyah_1131798_1597556301.mp3 [doi] => https://doi.org/10.18517/ijaseit.8.3.5441 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Tectonic Geomorphology of Upper Cimanuk Drainage Basin, West Java, Indonesia [journal_title] => International Journal on Advanced Science Engineering Information Technology [publisher] => Insights Society [year] => June 2018 [subject] => Geological Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/KwFLO9MvOeo [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/How-to-predict-tectonic-activity.mp4_snapshot_00.00_2021.08.03_23.31.15.png [figures] => ) ) [252] => WP_Post Object ( [ID] => 20004 [post_author] => 1 [post_date] => 2020-10-10 15:09:29 [post_date_gmt] => 2020-10-10 15:09:29 [post_content] => [post_title] => Identifying Best Treatment and Prevention for Delirium [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => identifying-best-treatment-and-prevention-for-delirium [to_ping] => [pinged] => [post_modified] => 2021-05-11 15:33:16 [post_modified_gmt] => 2021-05-11 07:33:16 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=20004 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SU, Kuan-Pin (蘇冠賓) [researchers_position] => Departments of Psychiatry, and Mind-Body Interface Laboratory, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/Kuan.png [researchers_profile] => https://www.researchgate.net/profile/Kuan-Pin_Su [researchers_second_profile] => https://orcid.org/0000-0002-4501-2502 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Meta Analysis; Preventive Intervention; Response Rate; Surface under the Cumulative Ranking Curve; JAMA; Pharmacological Interventions; Network Meta-analysis; Delirium; Randomized Clinical Trials; Network Meta Analysis; Jamapsychiatry [graphic_abstract] => [video] => https://www.youtube.com/embed/_My9X3WvKmM [the_novelty] =>

This is the first study that evaluates past evidence of pharmacological interventions for delirium treatment and prevention using network meta-analysis (NMA) method. Through a systematic review of randomized clinical trials, haloperidol with lorazepam was identified to provide the highest response rate among the other treatments for delirium. This effectiveness may be due to the reduced side effects associated with this combination drug. Furthermore, ramelteon was found to be the best antipsychotic drug to prevent the emergence of delirium. This is due to its readily binding property to melatonin receptors 1 and 2, which are hormone receptors associated with the development of delirium. Moreover, olanzapine was associated with the lowest occurrence rate of delirium. This study also proves that the treatment and preventive medications examined do not have lethal side-effects.

[the_background] =>

Despite the availability of numerous medications and treatments for delirium, the benefit and harm these interventions pose remained unclear. There have been some concerns about pharmacological interventions increasing mortality in this high-risk population. This study was to determine which medications provide the best delirium response rate, the lowest delirium occurrence rate, and the best tolerability for the treatment and prevention of delirium. By comparing different drugs commonly used in delirium treatment, the data narrowed down haloperidol combined with lorazepam as the best treatment, and ramelteon as the most suitable antipsychotics for prevention.

[the_sdg_impact] =>

Delirium is relatively common among elderly patients typically aged 60 years and older, with the prevalence between 9% and 87% among older people undergoing surgery. The goal of this study aligns with the third goal of the UN’s Sustainable Development Goals (SDG), which is “Good Health and Well-Being.” In 2018, a study by WHO stated that in the years to come, the proportion of the world’s population over 60 years would nearly double. As the number of people aged 60 years and older already outnumbers children younger than 5 years in 2020, a better understanding of which pharmacological interventions for delirium treatment and prevention are most suited will only prove beneficial to society. Since it was estimated that 30% to 40% of delirium cases are potentially preventable, with further studies based on the results of this research, there may be even better chances of its prevention in the future.

[article_url] => https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2726609 [main_image] => [podcast] => [doi] => https://doi.org/10.1001/jamapsychiatry.2018.4365 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Association of Delirium Response and Safety of Pharmacological Interventions for the Management and Prevention of Delirium A Network Meta-analysis [journal_title] => JAMA Psychiatry [publisher] => JAMA Network [year] => February 2019 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-27.jpg ) ) [253] => WP_Post Object ( [ID] => 19998 [post_author] => 1 [post_date] => 2020-10-10 15:06:51 [post_date_gmt] => 2020-10-10 15:06:51 [post_content] => [post_title] => Importance of Thyroid Hormone in Skeletal Muscle [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => importance-of-thyroid-hormone-in-skeletal-muscle [to_ping] => [pinged] => [post_modified] => 2021-05-23 12:07:29 [post_modified_gmt] => 2021-05-23 04:07:29 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19998 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LESMANA, Ronny [researchers_position] => Department of Basic Medical Sciences, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/17.jpg [researchers_profile] => https://www.researchgate.net/profile/Ronny_Lesmana [researchers_second_profile] => https://orcid.org/0000-0002-7425-915X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => biogenesis; light chain 3; microtubule-associated protein light chain 3B; electron microscopy; thyroid hormone; autophagy; skeletal muscle; Autophagyrelated gene; reactive oxygen species; AMPK [graphic_abstract] => [video] => [the_novelty] =>

While trying to exploring more about thyroid hormone (TH), this study showed that TH-mediated autophagy was essential for the stimulation of mitochondrial biogenesis and activity in skeletal muscle. Besides that, its pathway has been outlined clearly. Consistently results were observed in both in vitro and in vivo tests. The results indicate the presence of a huge room for future studies in investigating the roles of TH.

[the_background] =>

Numerous past studies were conducted to examine the roles and importance of TH. However, there was no information about the role of TH on autophagy in skeletal muscle. By conducting this study, it has been confirmed that TH stimulates skeletal muscle autophagy both in vitro and in vivo. This process is important in regulating skeletal muscle growth, regeneration, and differentiation. New findings like these play a critical role in paving the research path for more in-depth studies regarding TH. By gaining more knowledge, a better context of the human body can be established to improve our health in the future.

[the_sdg_impact] =>

The advancement of medical science and the health care sector relies mainly on the level of knowledge of how the human body works. With the findings of this study, a more complete understanding of TH has been established. Aligned with the UN’s aim to reduce premature mortality caused by preventable illnesses by 2030, the study aids in achieving Goal 3: Good Health and Well-being of the UNSDG.

[article_url] => https://academic.oup.com/endo/article/157/1/23/2251821 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-17-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Ronny-Lesmana_1094144_1597383095.mp3 [doi] => https://doi.org/10.1210/en.2015-1632 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle [journal_title] => Journal of Endocrinology [publisher] => Oxford Academic [year] => January 2016 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/o7RQYpt-TF0 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/38-w-subs-music.mp4_snapshot_00.01_2021.05.12_09.55.50.jpg ) ) [254] => WP_Post Object ( [ID] => 19992 [post_author] => 1 [post_date] => 2020-10-10 15:03:11 [post_date_gmt] => 2020-10-10 15:03:11 [post_content] => [post_title] => Improved Properties in Alumina Coated Aluminum Nanowires [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => improved-properties-in-alumina-coated-aluminum-nanowires [to_ping] => [pinged] => [post_modified] => 2021-05-12 10:42:18 [post_modified_gmt] => 2021-05-12 02:42:18 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19992 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ROSANDI, Yudi [researchers_position] => Department of Geofisika, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/43.jpg [researchers_profile] => https://www.researchgate.net/profile/Yudi_Rosandi [researchers_second_profile] => https://orcid.org/0000-0003-2387-1338 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => religious freedom; socio economic; Lembaga Survei Indonesia; Indonesian Family Life Survey; individual income; regression analysis; Indonesia; religious intolerance; conservatism; individual level [graphic_abstract] => [video] => [the_novelty] =>

To further understand the properties of aluminium (Al), this study has demonstrated that oxygen helped to increase the ductility of Al nanowires. When under tension, a reorganization of the structure of the oxide layer has led to bond healing and preventing fracture and decreasing significantly the number of crystal defects during tension and compression. The results were obtained using molecular dynamics simulation and computational analytic methods. Future studies can be carried out to optimize the toughness of nanodevices by making use of these results.

[the_background] =>

High-strength materials with lightweight are highly sought after in most of the mechanical designs nowadays. Al is well-known for its lightweight and superior mechanical properties. When Al is in the form of a nanowire, it has a higher surface-to-volume ratio and higher oxygen affinity. Hence, the oxide layer can form in seconds and it will change the properties of Al significantly. Meanwhile, the relations between the thickness of the oxidized layer, the strain rate and the mechanical response of nanowires to compression and tension have not been investigated intensively. Hence, this study was conducted to examine the modification of mechanical properties induced by the oxide layer at the surface of Al nanowires.

[the_sdg_impact] =>

In this era where nanotechnology is growing rapidly, mechanical designs at nanoscale must be able to keep up with the growth in order to optimize any nano-tech applications. The results of this study are important to the development and enhancement of nanodevices. As the UN strives to upgrade the technological capabilities of industrial sectors in all countries, this study contributes directly to achieving the UNSDG 9: Industry, Innovation and Infrastructure.

[article_url] => https://pubs.rsc.org/en/content/articlelanding/2020/RA/D0RA01206H#!divAbstract [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-43-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Yudi-Rosandi_1649492_1599990798.mp3 [doi] => https://doi.org/10.1039/d0ra01206h [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Molecular dynamics simulations of the mechanical behavior of alumina coated aluminum nanowires under tension and compression [journal_title] => Journal of RSC Advance [publisher] => Royal Society of Chemistry [year] => April 2020 [subject] => Geophysics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/EOO854rNfxc [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/45-w-subs-music.mp4_snapshot_00.01_2021.05.12_10.40.51.jpg ) ) [255] => WP_Post Object ( [ID] => 19985 [post_author] => 1 [post_date] => 2020-10-10 15:00:17 [post_date_gmt] => 2020-10-10 15:00:17 [post_content] => [post_title] => Improving Starch-digesting Enzyme Function with Computational Model [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => improving-starch-digesting-enzyme-function-with-computational-model [to_ping] => [pinged] => [post_modified] => 2021-07-16 11:55:54 [post_modified_gmt] => 2021-07-16 03:55:54 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19985 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YUSUF, Muhammad [researchers_position] => Department of Chemistry, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/7-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Muhammad_Yusuf69 [researchers_second_profile] => https://orcid.org/0000-0003-1627-1553 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => α-amylase; mutant 1; positive control; maltose; mutant 3; Sfamy R64; Surface Binding Site; α amylase; mutant 2; wild type; molecular dynamic [graphic_abstract] => [video] => [the_novelty] =>

This study used a computational model to improve the binding stability of the enzyme Saccharomycopsis fibuligera R64 α-amylase (Sfamy R64) for better raw starch digestion. By introducing a mutation at the surface binding site (SBS) of the enzyme through computer-aided molecular designing, results showed a longer binding time between the enzyme and the starch. Such was observed when compared between the original structure and the mutated structure of Sfamy R64 enzyme. Out of the three mutants used, the computational model predicted mutant 3 (MT3) to have significantly improved the starch binding stability of Sfamy R64.

[the_background] =>

Starch is widely used in the manufacturing of both food and non-food products, as well as extending its applications to important pharmaceutical products. Such extensive applications are impossible with raw starch; instead, proper processing and modification of the raw material are needed. However, starch processing is quite expensive due to the high temperature required to breakdown the complex molecules of starch. One of the most desired enzymes for starch digestion in Indonesia is Sfamy R64, but its raw starch adsorptivity is relatively low. Therefore, this study proposed a computer-aided molecular design of Sfamy R64 to improve its performance and stability. Ultimately, suggesting the potential of computational model approach in the development of manufacturing sectors involving enzymes.

[the_sdg_impact] =>

One of the beliefs of the United Nations is that the food and agriculture sector offers key solutions for development, and is a necessity to eradicate hunger and poverty. Since the starch processing industry overlaps with a number of food and agriculture industries, this study provides a basis for improving the starch digestion process and its affordability. Apart from that, with the aid of software to perfect the raw material structures, material wastage could also be reduced. Therefore, the extended benefits of this study go along well with the targets of SDG 2: Zero hunger and SDG 12: Responsible consumption and production.

[article_url] => https://www.dovepress.com/molecular-dynamics-study-to-improve-the-substrate-adsorption-of-saccha-peer-reviewed-article-AABC [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-7-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Muhammad-Yusuf_1092854_1597376665.mp3 [doi] => https://doi.org/10.2147/AABC.S198110 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Molecular dynamics study to improve the substrate adsorption of Saccharomycopsis fibuligera R64 alpha-amylase by designing a new surface binding site [journal_title] => Journal of Advances and Applications in Bioinformation and Chemistry [publisher] => Dove Press [year] => June 201 [subject] => Chemistry ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/p7wTU3SeY1M [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Improving-starch-digesting-enzyme-function-with-computational-model.mp4_snapshot_00.01_2021.07.16_11.53.30.png ) ) [256] => WP_Post Object ( [ID] => 19979 [post_author] => 1 [post_date] => 2020-10-09 06:20:23 [post_date_gmt] => 2020-10-09 06:20:23 [post_content] => [post_title] => Improving the Anti-Tumor Activity of T-Cell [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => improving-the-anti-tumor-activity-of-t-cell [to_ping] => [pinged] => [post_modified] => 2021-08-19 12:07:32 [post_modified_gmt] => 2021-08-19 04:07:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19979 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => HUNG, Mien-Chie (洪明奇) [researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/r1.png [researchers_profile] => https://www.researchgate.net/profile/Mien_Chie_Hung [researchers_second_profile] => https://orcid.org/0000-0003-4317-4740 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Cancer biology; Immunotherapy; Immune Checkpoint; PD-1; Post-translational Modification [graphic_abstract] => [video] => https://www.youtube.com/embed/ybjaFecU5sA [the_novelty] =>

This study provides a novel insight on the significance of programmed cell death protein 1 (PD-1) structure in T-cells and its role as a potential target site for immunotherapy. It is reported that the PD-1 glycosylation at N58 in T-cell is important to mediate the interaction between PD-1 and programmed cell death 1 ligand (PD-L1). This finding had led to the synthesis of an antibody, STM418. Upon performing tests on mice, the STM418 was found to display higher potential in enhancing the anti-tumor immunity compared to the FDA-approved nivolumab and pembrolizumab PD-1 antibodies. The STM418 was able to achieve this due to its higher binding affinity to PD-1, leveraging on the glycosylated site, followed by the neutralization of PD-L1/PD-1 binding. By preventing such binding, the T-cell will be more effective in its anti-tumor immune responses, hence, improving the overall efficacy of the immunotherapy.

[the_background] =>

In immunotherapy, T-cell is often the main subject as it plays a central role in the immune response. The PD-1 on T-cell is a protein known as an inhibitory receptor. Though the structure of glycosylated PD-1 is recognized, it’s functional significance, especially on the regulatory mechanism of T-cell activation was largely unknown. This study had established a better characteristic and mechanistic understanding of the interaction between T-cells and tumor cells. The findings showed the engagement of PD-1 with PD-L1 found on the surface of tumor cells led to the suppression of T-cell immune defense, creating an inefficacy in the anti-tumor immunity. That gave rise to the successful synthesis of the antibody, STM418, which showed a promising therapeutic blockade of tumor progression. The results of this study proved a significant breakthrough in immunotherapy, which could potentially serve as a remarkable reference for any future anti-cancer research.

[the_sdg_impact] =>

Oncology has always been a crucial area of study in medical science. The types of cancer treatment include (but not limited to) chemotherapy, immunotherapy, radiation therapy, hormone therapy, and surgery. In an attempt to improve the survival chance of cancer patients, researches are being conducted extensively in each type of treatment. The goal of this study shows good alignment with the “Goal 3: Good Health and Well-Being” of the UN’s Sustainable Development Goals (SDG). With an approximate 9.6 million global deaths reported by WHO in 2018, imagine if there is an effective way to treat cancer. This will restore not only the human’s physical wellness but also mental wellness. By conducting further studies based on the results of this research, it is optimistic that humans stand a better chance of battling cancer.

[article_url] => https://cancerres.aacrjournals.org/content/80/11/2298 [main_image] => [podcast] => [doi] => https://doi.org/10.1158/0008-5472.CAN-19-3133 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Targeting glycosylated PD-1 induces potent anti-tumor immunity [journal_title] => Cancer Research [publisher] => AACR Publication [year] => March 2020 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-35.jpg [figures] => ) ) [257] => WP_Post Object ( [ID] => 19974 [post_author] => 1 [post_date] => 2020-10-09 06:12:13 [post_date_gmt] => 2020-10-09 06:12:13 [post_content] => [post_title] => Feminine/Feminist Agency and Subjectivity in the Auto Biographies of Krisdayanti [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => feminine-feminist-agency-and-subjectivity-in-the-auto-biographies-of-krisdayanti [to_ping] => [pinged] => [post_modified] => 2021-07-19 12:07:52 [post_modified_gmt] => 2021-07-19 04:07:52 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19974 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => PRIYATNA, Aquarini [researchers_position] => Department of Literature and Cultural Studies, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/46.jpg [researchers_profile] => https://www.researchgate.net/profile/Aquarini_Priyatna [researchers_second_profile] => https://orcid.org/0000-0002-3009-1471 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => auto/ biography; mother daughter relationship; feminine; celebrity culture; mother-daughter relationship; biography; feminist mothering; Indonesia; motherhood; cultural studies; biographies [graphic_abstract] => [video] => [the_novelty] =>

This article as a whole helps us see how a mother-daughter relationship becomes more apparent with feminist mothering. Through the autobiographies of Krisdayanti, this article highlights how motherhood and mother-daughter relationship plays a vital role in enabling the development of feminist agency and subjectivity in a mother and daughter. The act of “mothering” does not only apply for mothers towards their daughters but vice versa as well. In the biographies, the relationship that Krisdayanti shared with her mother and later on with her children, shows that they viewed the feminine traits of motherhood as empowering, openly accepted and carried out despite the fixed identity roles that have been set by society.

[the_background] =>

Feminine agency and subjectivity can be briefly described as how women strive to live and rise in a male-dominated society and how these women view their roles as a factor that contributes to their identity. As for autobiographies, especially on Indonesian female celebrities, motherhood is something that is often focused on, as seen in Krisdayanti’s. The importance of motherhood and how it contributes to their daughter’s female empowerment/feminine strength is widely discussed in this article, especially as Krisdayanti’s mother openly embraced the role of providing a livelihood for her family, which is usually seen as a masculine trait. Overall, her mother has portrayed feminine traits that empowered her daughters to be independent and develop their own agency and subjectivity.

[the_sdg_impact] =>

According to a report by the World Economic Forum on the global gender gap, it will take approximately 108 years to reach gender parity and gender equality. With this rate, it will be long before the future generation of daughters can experience equal treatment and opportunities that go against society’s stereotypes against women. The message behind this article can be related to “Goal 5: Achieve gender equality and empower all women and girls” of the UN’s Sustainable Development Goals (SDG). One of the targets under this goal is to “ensure women have full and effective participation and equal opportunities for leadership at all levels of decision making in political, economic and public life.” The example set by Krisdayanti’s mother clearly shows feminine empowerment and leadership. This is important as her daughters were exposed to these traits hence preparing them to take on leadership roles in the future, which can help in the process of closing the gender gap.

[article_url] => https://journals.ateneo.edu/ojs/index.php/kk/article/view/KK2020.03310 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-46-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Aquarini-Priyatna_1683013_1600148903.mp3 [doi] => https://doi.org/10.13185/KK2020.03310 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Mothering Celebrities: Feminine/Feminist Agency and Subjectivity in the Auto/biographies of an Indonesian Female Celebrity [journal_title] => International Electronic Journal of Literary, Language, and Cultural Studies [publisher] => Ateneo de Manila University [year] => May 2018 [subject] => Literature and Cultural Studies ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/omH9ZmwIXmk [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Feminist-Agency-and-Subjectivity-in-the-Auto-Biographies-of-Krisdayanti.mp4_snapshot_00.01_2021.07.16_11.57.00.png ) ) [258] => WP_Post Object ( [ID] => 19969 [post_author] => 1 [post_date] => 2020-10-09 06:00:31 [post_date_gmt] => 2020-10-09 06:00:31 [post_content] => [post_title] => Factors Affecting the Motivation and Performance of Forensic Examiners [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => factors-affecting-the-motivation-and-performance-of-forensic-examiners [to_ping] => [pinged] => [post_modified] => 2021-07-19 11:17:28 [post_modified_gmt] => 2021-07-19 03:17:28 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19969 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MOHAMMAD, Benny Alexandri [researchers_position] => Department of Business Administration, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/unpad2.jpg [researchers_profile] => https://www.researchgate.net/profile/Moh_Alexandri [researchers_second_profile] => http://orcid.org/0000-0003-2032-6238 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => forensic examiner; table value of 0.222; central forensic laboratory; work discipline; POLRI; Performance of Forensic Examiner; Motivation; Competence [graphic_abstract] => [video] => [the_novelty] =>

As an effort to overcome the decline in work performance, this study reported the effect of work competence and discipline on motivation and its impact on the performance of forensic examiners for the National Police Bareskrim. It was conducted via data collection through questionnaires distributed to 78 respondents, followed by the application of analytical methods, including multiple linear regressions with path analysis and Sobel test. For a more in-depth study in the near future, scientists may include variables such as job satisfaction variables, organizational climate, compensation, and organizational culture, to have a better understanding of factors affecting performance.

[the_background] =>

There had been a decline in the completion of examination cases of evidence by the Center for Forensic Laboratory of the National Police Bareskrim (Puslabfor Bareskrim POLRI) from 2012 to 2016. Besides that, the forensic examiners who were present in full during working hours only ranged from 40% -55%. In order to increase the overall performance, this study had been carried out to investigate how competence, discipline, motivation, and performance influence one another. By leveraging the output of this investigation, initiatives and strategies can be established to improve the performance of various departments.

[the_sdg_impact] =>

In 2017, McKinsey Global Institute reported that 75 to 375 million people might need to switch occupations due to the adoption of automation. This implied that if the work performance of humans is not up to expectation, humans can be easily replaced by computers and machines. Since the UN targets to achieve full and productive employment and decent work for all women and men by 2030, this study was conducted to enhance the performance of the workforce to meet the Goal 8: Decent Work and Economic Growth of UNSDG.

[article_url] => https://www.abacademies.org/abstract/the-effect-of-competence-and-discipline-of-work-on-motivation-and-its-impact-on-performance-of-forensic-checkers-at-pusl-8320.html [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-16-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Mohammad-Benny-Alexandri_1094022_1597382542.mp3 [doi] => [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The Effect of Competence and Discipline of Work on Motivation and its Impact on Performance of Forensic Checkers at Puslabfor Bareskrim Indonesia National Police (POLRI) from the , 2019 [journal_title] => Academy of Strategic Management Journal [publisher] => Allied Business Academies [year] => 2019 [subject] => Business; Forensic ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/QAHYaAXV-w4 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/37-w-subs-music.mp4_snapshot_00.00_2021.05.12_09.44.24.jpg ) ) [259] => WP_Post Object ( [ID] => 19964 [post_author] => 1 [post_date] => 2020-10-09 05:49:22 [post_date_gmt] => 2020-10-09 05:49:22 [post_content] => [post_title] => Evaluating the Technical Efficiency of F&B Industry [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => evaluating-the-technical-efficiency-of-fb-industry [to_ping] => [pinged] => [post_modified] => 2021-05-12 10:26:07 [post_modified_gmt] => 2021-05-12 02:26:07 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19964 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SETIAWAN, Maman [researchers_position] => Department of Economics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/40.jpg [researchers_profile] => https://www.researchgate.net/profile/Maman_Setiawan [researchers_second_profile] => https://orcid.org/0000-0001-5141-0104 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Indonesian food; technical efficiency; Dynamic technical inefficiency; Industrial concentration; granger causality; Hirschman index; technical inefficiency; quiet life hypothesis; Indonesian food and beverages industry; adjustment cost [graphic_abstract] => [video] => [the_novelty] =>

This study showed that the Indonesian food and beverages (F&B) industry has a high dynamic technical inefficiency. Besides that, industrial concentration has a positive correlation with the dynamic technical inefficiency. Panel data of 44 subsectors in the Indonesian food and beverage industry for the period 1980-2014 had been analyzed using various statistic analytical tools. This study raises an issue about the inaccurate measure of the technical inefficiency using static approach by providing a measure of dynamic technical inefficiency. The modeling approach applied in this study can also be applied to evaluate other industries (other than F&B) accurately in any future studies.

[the_background] =>

Industrial concentration refers to the extent to which production is concentrated among firms in an industry. Technical efficiency is the effectiveness with which a given set of inputs is used to produce an output. Past research that studied the relation between industrial concentration and performance relies on static measures of performance, including technical efficiency. However, static measures provide an inaccurate metric of the firms’ performance in the presence of adjustment costs associated with the investment. Such inaccuracy will, in turn, affect the decision-making process of policymakers negatively. Thus, this research aimed to enhance the data reliability and accuracy by measuring the dynamic technical inefficiency accounting for the presence of the adjustment cost as well as its relation with an industrial concentration in the Indonesian F&B industry.

[the_sdg_impact] =>

The economic growth of a country depends a lot on the awareness of policymakers. Therefore, an in-depth report like this one is crucial as it not only highlights the current state of the economy, but also gives practical suggestions for improvement. The UN aims to promote development-oriented policies that support productive activities. Hence, by using these findings as a reference in making or amending economic and industrial policy, it will be a great effort towards materializing Goal 8: Decent Work and Economic Growth and Goal 9: industry, innovation and infrastructure of UNSDG.

[article_url] => https://www.emerald.com/insight/content/doi/10.1108/BFJ-04-2017-0226/full/html [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-40-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Maman-Setiawan_1647312_1599972715.mp3 [doi] => https://doi.org/10.1108/BFJ-04-2017-0226 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Dynamic technical inefficiency and industrial concentration in the Indonesian food and beverages industry [journal_title] => British Food Journal [publisher] => Emerald Publishing [year] => January 2018 [subject] => Economics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/GHqKoi7Y-g0 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/41-w-subs-music.mp4_snapshot_00.03_2021.05.12_10.13.02.jpg ) ) [260] => WP_Post Object ( [ID] => 19959 [post_author] => 1 [post_date] => 2020-10-09 05:45:03 [post_date_gmt] => 2020-10-09 05:45:03 [post_content] => [post_title] => Evaluating the Risk of Alzheimer’s Disease in Diabetic Patients [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => evaluating-the-risk-of-alzheimers-disease-in-diabetic-patients-2 [to_ping] => [pinged] => [post_modified] => 2021-05-11 15:37:15 [post_modified_gmt] => 2021-05-11 07:37:15 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19959 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LIN, Cheng-Chieh (林正介) [researchers_position] => School of Medicine, College of Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/chew.jpg [researchers_profile] => https://www.researchgate.net/scientific-contributions/2113137329-Cheng-Chieh-Lin [researchers_second_profile] => http://orcid.org/0000-0002-9625-6216 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => COPD; Congestive Heart Failure; Oral Hypoglycemic Drug; Chronic Obstructive Pulmonary Disease; Hypoglycemic Drug; SD Change; Year Measurement; Coronary Artery Disease; Plasma Glucose; Diabetes [graphic_abstract] => [video] => https://www.youtube.com/embed/RUfkDYNlUpU [the_novelty] =>

This study aims to improve diabetes care management strategies and to decrease the risk of diabetes-related complications in patients. It is the first largest population study that focused on identifying the correlation between Type 2 Diabetes Mellitus (T2DM) and the development of Alzheimer’s Disease (AD). The results of this observation proved that fasting plasma glucose (FPG) and glycated hemoglobin (HBA1C) were significant in the prevalence of AD among diabetes patients. A shared pathophysiological link between blood glucose level variation and AD was determined. By monitoring the FPG and HBA1C coefficient of variation based on every visit, a more sensitive and efficient clinical management of TD2M could be established, and the risk of AD could be reduced.

[the_background] =>

Type 2 Diabetes Mellitus (T2DM) is associated mainly with poor lifestyle and diet system, which, if left unchecked, could lead to a range of severe clinical complications. Past studies have linked diabetes to the development of vascular dementia and as a risk factor of Alzheimer’s Disease (AD). However, there is still a lack of evidence relating current T2DM clinical management strategies with cognitive dysfunction. This study addressed an association between blood glucose level variation and its potential in increasing the risk of AD. The results provide new insights into glucose control and AD prevention in diabetes care, which could be used to initiate lifestyle modification intervention for secondary prevention by healthcare personnel.

[the_sdg_impact] =>

In 2016, WHO estimated diabetes as the seventh leading cause of death, with about 1.6 million fatalities reported due to high blood glucose. Those above 18 years old who were diagnosed with diabetes increased from 4.7% in 1980 to 8.5% in 2014, and the incident rate has been rising ever since. As life expectancy continues to extend, more and more people are living with diabetes with deteriorating cognitive function and other chronic diseases. This study offers an efficient screening and management approach to monitor the development of Alzheimer’s Disease among diabetes patients. Such early detection and prevention intervention align well with the UN SDG 3: Good Health and Well-being in improving the mortality rate and quality of life.

[article_url] => https://care.diabetesjournals.org/content/40/9/1210 [main_image] => [podcast] => [doi] => https://doi.org/10.2337/dc16-2238 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Visit-to-Visit Variations in Fasting Plasma Glucose and HbA1c Associated With an Increased Risk of Alzheimer Disease: Taiwan Diabetes Study [journal_title] => Diabetes Care [publisher] => American Diabetes Association [year] => July 2017 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-36.jpg ) ) [261] => WP_Post Object ( [ID] => 19954 [post_author] => 1 [post_date] => 2020-10-09 05:36:57 [post_date_gmt] => 2020-10-09 05:36:57 [post_content] =>     [post_title] => Effective Paediatric Pain Management Hindered by Organizational Structural & Cultural [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => effective-paediatric-pain-management-hindered-by-organizational-structural-cultural [to_ping] => [pinged] => [post_modified] => 2021-07-03 14:27:55 [post_modified_gmt] => 2021-07-03 06:27:55 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19954 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MEDIANI, Henny Suzana [researchers_position] => Department of Pediatric Nursing, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/37.jpg [researchers_profile] => https://www.researchgate.net/profile/Henny_Mediani3 [researchers_second_profile] => https://orcid.org/0000-0001-6960-3692 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => grounded theory; collins; pain care; effective pain management; effective pain care; children; pain assessment; paediatric patient; pain management [graphic_abstract] => [video] => [the_novelty] =>

While trying to improve pediatric pain management in Indonesia, this study aimed to identify several organizational structural and cultural factors that were thought to hinder the nurses’ provision of effective pain care to pediatric patients. A qualitative study was conducted via in-depth interviews to record 37 Indonesian nurses’ perceptions of barriers to pediatric pain management in two hospitals. By making use of these findings, the relevant departments and authorities could have a clearer picture of how to improve clinical nurses’ performance and capability in providing pain care to pediatric patients. Future studies can be conducted to examine physicians’ perceptions and experiences regarding the subject matter.

[the_background] =>

Despite the fact that various research and clinical studies on all aspects of pain have been carried out globally, children continue to experience moderate to severe pain during hospitalization. Furthermore, practices remain unable to achieve the ideal scenario, and the factors affecting pain management, as well as its implementation, have not been well identified. Hence, this study was conducted to help eliminate the barriers impeding effective practice in pediatric pain management. Besides nurse-related barriers, past studies also reported that the barriers to pain assessment and management include patient-related barriers, physician-related barriers and system-related barriers. By making an effort to overcome each of these, the well-being of hospitalized children can be further improved.

[the_sdg_impact] =>

Every day, children are being admitted to hospitals for medical attention and are exposed to pain during treatment. Uncontrolled pain might impair the physical, social and psychological functions of pediatric patients. This might also lead to chronic pain in adulthood. For the sake of the well-being of pediatric patients, the current study shows potential to achieve Goal 3: Good Health and Well-being of the UNSDG.

[article_url] => https://journals.sagepub.com/doi/10.1177/1367493517715146 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-37-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Henry-Suzana-Mediani_1597021_1599720061.mp3 [doi] => https://doi.org/10.1177/1367493517715146 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => An exploration of Indonesian nurses’ perceptions of barriers to paediatric pain management [journal_title] => Journal of Child Health Care [publisher] => Sage Publishing [year] => June 2017 [subject] => Pediatric; Nursing ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/XJO3tv3ubaQ [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-6.jpg ) ) [262] => WP_Post Object ( [ID] => 19948 [post_author] => 1 [post_date] => 2020-10-09 05:32:24 [post_date_gmt] => 2020-10-09 05:32:24 [post_content] => [post_title] => Effective Encapsulant for Red Ginger Extract Powder Using Mixture of Maltodextrin and Gum Arabic [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => effective-encapsulant-for-red-ginger-extract-powder-using-mixture-of-maltodextrin-and-gum-arabic [to_ping] => [pinged] => [post_modified] => 2021-05-22 22:51:32 [post_modified_gmt] => 2021-05-22 14:51:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19948 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => NURHADI, Bambang [researchers_position] => Department of Food Industrial Technology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/14.jpg [researchers_profile] => https://www.researchgate.net/profile/Bambang_Nurhadi2 [researchers_second_profile] => https://orcid.org/0000-0002-5276-8236 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => total flavonoid content; encapsulant material; maltodextrin; gum arabic; Stability; red ginger extract powder; Red ginger extract; emprit ginger; antioxidant activity; bioactive compound [graphic_abstract] => [video] => [the_novelty] =>

In the process of creating a more viable encapsulant, this study reported that the higher amount of gum arabic used in encapsulant materials had contributed better protection to the stability of bioactive compounds of the red ginger extract powder during storage. Compared to maltodextrin: gum arabic ratio 10:0 and 8:2, ratio 5:5 showed the best stability. The powders were characterized using up to eight methods to determine the results. Based on literature, there are possibilities to further improve the overall effectiveness of the encapsulant materials by introducing modified starch or other potential materials. This could be a future direction to be explored.

[the_background] =>

In comparison to the raw form, ginger extract has more advantages, including more practical for food processing, lower transportation cost, lower chance of microbial contamination, and longer shelf life. However, its viscous and sticky textures make it less feasible to be processed for industrial applications. More importantly, the unstable bioactive compounds in ginger extract might undergo destructive chemical changes during storage. That is why coming up with suitable encapsulant materials is necessary to protect the stability of the bioactive compounds and to extend the overall shelf life of ginger extract. Apart from being low cost and has high availability, maltodextrin is a glass former which can prevent the core material from oxidation. When combined with gum arabic, the combination could form a high-potential encapsulant. To date, there is insufficient literature regarding the characteristics of red ginger extract powder during storage and the effect of encapsulant materials (specifically maltodextrin and gum arabic) on the characteristics. Thus, this study was carried out to investigate the optimal ratio of maltodextrin and gum arabic as encapsulant materials, as well as their effects on the characteristics of ginger extract. By having a reliable encapsulant, the shelf life of various substances, including medicines, can be extended.

[the_sdg_impact] =>

The global volume of food wastage is estimated at 1.6 billion tonnes (Source: FAO of the UN). With the established transportation modes, transporting goods is no longer a hassle. Nevertheless, the lead time and storage conditions during transit might be a limitation, especially for food-related goods. Hence, it is necessary to come up with methods to extend the shelf life of these goods. This study had reported a promising formulation to create an encapsulant which maintains the stability of the bioactive compounds in ginger abstract. Since the UN aims to achieve the sustainable management and efficient use of natural resources by 2030, the outcome of this study is a significant step towards realizing the Goal 12: Responsible Consumption and Production of UN’s Sustainable Development Goals (SDG).

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0308814620313522?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-14-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Bambang-Nurhadi_1093669_1597380549.mp3 [doi] => https://doi.org/10.1016/j.foodchem.2020.127490 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The role of encapsulant materials on the stability of bioactive compounds of red ginger (Zingiber officinale Roscoe. var. Rubrum) extract powder during storage [journal_title] => Journal of Food Chemistry [publisher] => Elsevier [year] => December 2020 [subject] => Food Science ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/fFrJr_PrP1A [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-7.jpg ) ) [263] => WP_Post Object ( [ID] => 19942 [post_author] => 1 [post_date] => 2020-10-09 05:27:27 [post_date_gmt] => 2020-10-09 05:27:27 [post_content] => [post_title] => Effect of Milking Practices and Diet on Dairy Cow Health [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => effect-of-milking-practices-and-diet-on-dairy-cow-health [to_ping] => [pinged] => [post_modified] => 2022-07-04 15:24:17 [post_modified_gmt] => 2022-07-04 07:24:17 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19942 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MAYASARI, Novi [researchers_position] => Department of Animal Nutrition and Feed Technology, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/27.jpg [researchers_profile] => https://www.researchgate.net/profile/Novi_Mayasari2 [researchers_second_profile] => https://orcid.org/0000-0003-4867-1025 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => continuous milking, metabolic status, inflammation, oxidative stress, liver functionality and milk yield [graphic_abstract] => [video] => [the_novelty] =>

Researchers attempt to study the effect of milking schedule and dietary supplies on improving the energy balance and metabolic status of dairy cows within the first month of calving. The results showed that cows undergoing continuous milking until delivery led to high levels of cholesterol, ceruloplasmin, haptoglobin, and reactive oxygen metabolites (ROM) in plasma. Lower liver functionality index along with lower bilirubin and paraoxonase levels were also observed in cows with a 0-day dry period. These findings proved that by omitting the dry period prior to the delivery improved the energy balance and metabolic status of the dairy cows. Furthermore, the reduced production of milk during early lactation due to continuous milking before birthing reduced inflammation and oxidative stress too. However, such practice, independent of the feed, was found to trigger extended health complications, especially with the increase in haptoglobin and ceruloplasmin levels.

[the_background] =>

Past studies have proven that cows regularly milked throughout the pregnancy period show better energy balance and metabolic health in the next lactation. However, controversies were surrounding such claims as there was still a lack of evidence in terms of inflammatory biomarkers in dairy cow plasma and liver functionality. This research intended to fill in the knowledge void related to the milking patterns of dairy cows and the type of ration fed, and the effect on the energy balance and metabolic health of postpartum dairy cows.

[the_sdg_impact] =>

According to the statistics shared by the Food and Agriculture Organization of the United Nations, worldwide milk production has increased by more than 59% over the past 3 decades. That said, animal diseases leading to increased death rate or reduced productivity in dairy animals are causing substantial economic losses. This research provides an in-depth understanding of the effects of milking practices on the health and longevity of the dairy cows. With that, diary farmers could protect livestock accordingly and ultimately maintain economic growth, and fight hunger, malnutrition and poverty. All of which could contribute to the realization of SDG 1: No poverty, and SDG 2: Zero hunger.

[article_url] => https://www.journalofdairyscience.org/article/S0022-0302(17)30272-2/fulltext [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/cow7.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Novi-Mayasari2_1557915_1599561939.mp3 [doi] => https://doi.org/10.3168/jds.2016-11857 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Effects of dry period length and dietary energy source on inflammatory biomarkers and oxidative stress in dairy cows [journal_title] => Journal of Dairy Science [publisher] => American Dairy Science Association [year] => March 2017 [subject] => Animal Nutrition; Feed Technology ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/zbjjEtUNEdA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Effect-of-milking-practices-and-diet-on-dairy-cow-health.mp4_snapshot_00.01_2021.08.03_23.47.17.png [figures] => ) ) [264] => WP_Post Object ( [ID] => 19937 [post_author] => 1 [post_date] => 2020-10-09 05:22:32 [post_date_gmt] => 2020-10-09 05:22:32 [post_content] => [post_title] => Curcumin: Treatment for Acute Oral Inflammation Pain [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => curcumin-treatment-for-acute-oral-inflammation-pain [to_ping] => [pinged] => [post_modified] => 2021-05-12 10:43:53 [post_modified_gmt] => 2021-05-12 02:43:53 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19937 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MAULINA, Tantry [researchers_position] => Department of Oral Surgery, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/44.jpg [researchers_profile] => https://www.researchgate.net/profile/Tantry_Maulina2 [researchers_second_profile] => https://orcid.org/0000-0002-6975-990X ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Numeric rating scale; post ­surgical removal; control group; therapeutic intensity score; current study; surgical removal; non-­steroid anti-­inflammatory drug; curcumin; acute inflammation pain; inflammation [graphic_abstract] => [video] => [the_novelty] =>

As part of the oral and facial pain management, this current study reported that curcumin was effective in treating acute inflammation pain in the post-surgical removal of impacted third molars (also known as wisdom teeth) patients. With ninety patients that were recruited, randomly assigned, and evaluated for this study, the intensity of pain experienced by these patients at several time intervals was evaluated by using a numeric rating scale. Hopefully, the findings of this study can be used as scientific evidence for future studies that are aiming to explore the therapeutic potentials of natural remedies.

[the_background] =>

Surgical removal of impacted third molars is one of the dental procedures that have the potential to induce acute post-surgery inflammation pain in the oral region. Past studies have reported that curcumin possesses the ability to reduce or better yet eliminate acute inflammation pain, including the one that arises after surgical procedures. Nonetheless, no study has ever evaluated the efficacy of curcumin in managing acute inflammation pain due to the third-molar removal procedure. Therefore, this study aimed to assess the efficacy of curcumin in managing acute inflammation pain on post-surgical removal of impacted third molars patients.

[the_sdg_impact] =>

Although acute post-surgical inflammation pain is common and expected, pain management is still a priority in medical science to ensure the well-being of patients. This study has successfully proven the efficacy of curcumin as a natural ingredient in relieving acute post-surgical inflammation pain. Aligned with the UN’s target to support the research and development of medicines, this could contribute to achieving the UNSDG 3: Good Health and Well-Being.

[article_url] => https://onlinelibrary.wiley.com/doi/abs/10.1111/joor.12679 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-44-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Tantry-Maulina_1681742_1600140778.mp3 [doi] => https://doi.org/10.1111/joor.12679 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The efficacy of curcumin in managing acute inflammation pain on the post‐surgical removal of impacted third molars patients: A randomised controlled trial [journal_title] => Journal of Oral Rehabiitation [publisher] => Wiley [year] => June 2018 [subject] => Oral Surgery ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/aw_e9AKyjCA [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/46-w-subs-music.mp4_snapshot_00.00_2021.05.12_10.42.27.jpg ) ) [265] => WP_Post Object ( [ID] => 19823 [post_author] => 1 [post_date] => 2020-10-07 06:33:51 [post_date_gmt] => 2020-10-07 06:33:51 [post_content] => [post_title] => What influences consumers’ willingness to pay for electricity services? [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => what-influences-consumers-willingness-to-pay-for-electricity-services [to_ping] => [pinged] => [post_modified] => 2021-07-16 11:22:16 [post_modified_gmt] => 2021-07-16 03:22:16 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19823 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SIYARANAMUAL, Martin [researchers_position] => Department of Economics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/5-1.jpg [researchers_profile] => https://www.researchgate.net/profile/Martin_Siyaranamual [researchers_second_profile] => https://orcid.org/0000-0002-7057-4275 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => latent class logit; willingness to pay; conditional logit; rural electrification ratio; Choice experiments; mixed logit; Electricity service; discrete choice experiment [graphic_abstract] => [video] => [the_novelty] =>

This research provided an in-depth understanding of the factors influencing urban consumers’ willingness to pay for electricity service. Among the four factors identified were geographical accessibility, quality of access, source of electricity, and tariffs. This research was also the first to use a discrete choice experiment (DCE) in Indonesia to gauge the consumer preferences of the electricity sector. The results of the analysis indicated that consumers are willing to pay a higher tariff for electricity if the quality and accessibility can be improved. Therefore, policymakers can now make informed decisions on financial allocations without compromising social welfare. With that said, further research considering the opinions of industrial and commercial users is suggested for a better overview of consumer preferences towards improving electricity service.

[the_background] =>

The Indonesian government aims to improve electricity supply and achieve 99.7% of electricity coverage nationwide while reducing greenhouse gas emissions by 26% by the year 2025. The existing flaws in the current electricity service are the frequent power shortages, lack of proper facilities in rural areas, and the over-reliance on coal as an energy source. In order to improve the current electricity service, a substantial amount of investment is required, which would directly affect the cost paid by the consumers. The findings of this study, therefore, provides the policymakers real-time data to base their decisions upon.

[the_sdg_impact] =>

As reported in the Global Energy Statistical Yearbook 2020, there was a slight increase in global electricity consumption in the year 2019, while a significant decline in global and Indonesian coal consumption was observed. In line with the aims of the UN SDG 7: Affordable and clean energy, this study could be used as a reference to implement affordable, reliable, sustainable, and modern energy for all.

[article_url] => https://www.sciencedirect.com/science/article/pii/S2352484719303191 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-5-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Martin-Siyaranamual_1092675_1597375664.mp3 [doi] => https://doi.org/10.1016/j.egyr.2020.02.018 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Consumers’ willingness to pay for electricity service attributes: A discrete choice experiment in urban Indonesia [journal_title] => Journal of Energy Reports [publisher] => Elsevier [year] => November 2020 [subject] => Economics; Energy ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/RRGNuLvSPDE [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/What-influences-consumers-willingness-to-pay-for-electricity-service.mp4_snapshot_00.01_2021.07.16_11.20.36.png ) ) [266] => WP_Post Object ( [ID] => 19816 [post_author] => 1 [post_date] => 2020-10-07 06:27:15 [post_date_gmt] => 2020-10-07 06:27:15 [post_content] => [post_title] => Cost and Challenges of Establishing Maternity Protection at Workplace [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => cost-and-challenges-of-establishing-maternity-protection-at-workplace [to_ping] => [pinged] => [post_modified] => 2021-05-11 15:40:18 [post_modified_gmt] => 2021-05-11 07:40:18 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19816 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SIREGAR, Adiatma [researchers_position] => Department of Economics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/49.jpg [researchers_profile] => https://www.researchgate.net/profile/Adiatma_Siregar [researchers_second_profile] => https://orcid.org/0000-0003-0747-1596 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => World Development Indicators; Maternity leave; International Labour Organization; maternity protection program; United Nation’s Children Fund; breast milk substitutes; indonesia; Maternity protection; lactation room; Breastfeeding [graphic_abstract] => [video] => [the_novelty] =>

Maternity protection poses various benefits to breastfeeding mothers and their children. The costs of maternity protection were estimated through the calculation of existing information regarding population growth, estimated cost of paid maternity leave, and the cost of setting up private space for breastfeeding mothers to use breast pumps. The challenges faced in establishing maternity protection programs were determined by asking sets of open-ended questions to workers from different work sectors and organizations. Maternity protection, such as 6 months paid maternity leave, and private space for breastfeeding mothers allow breastfeeding mothers to practice the recommended breastfeeding practice set by the World Health Organisation (WHO). This practice benefits both the mothers and their children as it reduces infant and maternal death rates, cancer rates in pregnant mothers, and loss of mental processes in infants as well as improves the country’s economy. The study shows that such practice is economically feasible and well below the costs of not breastfeeding. Future studies could investigate the association between maternity protection and the employment of women.

[the_background] =>

The outcome of this study can be used by people involved in developing policies (policymakers) to understand that establishing maternity protection affects not only the working mother but also the workplace culture and the economy of the country. The goal of this study is to provide policymakers with sufficient knowledge of the cost and challenges involved in establishing the recommended maternity protection. The limitations of existing policies in Indonesia are that maternity leave given is only at the minimum recommended maternity leave, and not all women are cared for under these policies as the implementation differs in each company. A possible solution to overcome the limitations is recommended maternity protection policies should be implemented in all companies throughout the country. Another possible modification is to increase the length of maternity leave from 13 weeks to a minimum of six months. Such is only possible through the collaboration of government, private sectors and companies in sharing the cost in establishing policies.

[the_sdg_impact] =>

Maternity protection is a form of women’s rights entitled to working females to secure their job and earn a minimum salary while being pregnant. The policy provides a form of protection towards the health of pregnant mothers and their children. The “Goal 10: Reduce Inequalities” of the UN’s Sustainable Development Goals (SDG) is the focus of this study. The provision of proper maternity protection promotes the empowerment of women in various work sectors. It also prevents pregnancy and motherhood from being a hurdle for women to complete their tasks at the workplace and explore different types of jobs. Establishing maternity protection creates a workplace culture that cares for the needs of women, which is essential in producing a society that treats men and women as equals.

[article_url] => https://internationalbreastfeedingjournal.biomedcentral.com/articles/10.1186/s13006-019-0221-1 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-49-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Adiatma-Siregar_1710519_1600268252.mp3 [doi] => https://doi.org/10.1186/s13006-019-0221-1 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The financing need for expanded maternity protection in Indonesia [journal_title] => International Breastfeeding Journal [publisher] => BMC [year] => June 2019 [subject] => Economics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/mN1oelXGxHY [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-11.jpg ) ) [267] => WP_Post Object ( [ID] => 19798 [post_author] => 1 [post_date] => 2020-10-07 06:11:38 [post_date_gmt] => 2020-10-07 06:11:38 [post_content] => [post_title] => Assessing the Happiness of Being Fishers [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => assessing-the-happiness-of-being-fishers [to_ping] => [pinged] => [post_modified] => 2021-06-26 12:02:21 [post_modified_gmt] => 2021-06-26 04:02:21 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19798 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ANNA, Zuzy [researchers_position] => Department of Fisheries , Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/20.jpg [researchers_profile] => https://www.researchgate.net/profile/Zuzy_Anna [researchers_second_profile] => https://orcid.org/0000-0001-7880-6483 ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => demographics; life survey; subjective economic ladder; life satisfaction; non fisherman; regional characteristics; Corresponding; Authors; Indonesian Family Life Survey; positive attitude [graphic_abstract] => [video] => [the_novelty] =>

To resolve questions about the happiness associated with being a fisherman, this study has reported that fishers, who are self-employed with workers, are happier than non-fishers. Also, fishers are generally more optimistic in life, especially towards the future change in economic status. The findings were obtained by applying statistical analysis methods on a database of a survey of almost 20,000 individuals from which fishers and non-fishers can be identified. Further studies can be conducted to investigate the causation of these findings.

[the_background] =>

Various studies have reported that fishers derived considerable satisfaction from their work, regardless of whether they were full- or part-timers. However, the literature on life satisfaction among fishers does not represent whether being fishermen is generally associated with either higher or lower life satisfaction. That is because the former focuses on the well-being among fishers but the latter is a comparison between being fishermen and non-fishermen. Hence, this study, which aimed to assess the happiness of fishers, has involved non-fishers as controls in its investigation to come up with a more reasonable and relevant comparison.

The SDG Impact

[the_sdg_impact] =>

Happiness is a crucial indication of the well-being of humans. Constant exposure to unhappiness can lead to negative implications, such as depression and suicidal tendencies. This study has developed a methodology to study the life satisfaction of humans based on occupation. It will be useful to measure the well-being of a worker and, therefore, able to reduce unwanted incidents that arise from unhappiness at the workplace. Through promoting mental health and well-being, this study contributes towards the achievement of UNSDG 3: Good Health & Well-Being.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0308597X18308960 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-20-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Zuzy-Anna_1094489_1597384691.mp3 [doi] => https://doi.org/10.1016/j.marpol.2019.103559 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Are fishermen happier? Evidence from a large-scale subjective well-being survey in a lower-middle-income country [journal_title] => Journal of Marine Policy [publisher] => PLOS One [year] => August 2019 [subject] => Fisheries ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/YwzEz4UxXUU [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/49-w-subs-music.mp4_snapshot_00.01_2021.05.12_10.47.18.jpg ) ) [268] => WP_Post Object ( [ID] => 19786 [post_author] => 1 [post_date] => 2020-10-07 06:06:00 [post_date_gmt] => 2020-10-07 06:06:00 [post_content] => [post_title] => A Cost-Effective Intervention to Overcome Dengue Infection [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => a-cost-effective-intervention-to-overcome-dengue-infection [to_ping] => [pinged] => [post_modified] => 2021-07-03 15:13:16 [post_modified_gmt] => 2021-07-03 07:13:16 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19786 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SUWANTIKA, Auliya A. [researchers_position] => Department of Pharmacology and Clinical Pharmacy Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/39.jpg [researchers_profile] => https://www.researchgate.net/profile/Auliya_Suwantika2 [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => dengue haemorrhagic fever; wolbachia program; cost effectiveness; dengue vaccination; dengue fever; quality-adjusted life year; cost-effective; health education; dengue infection [graphic_abstract] => [video] => [the_novelty] =>

With the intention to reduce cases of dengue infection, this study confirmed that vaccination combined with a Wolbachia program was the most cost-effective intervention of dengue infection, compared to two other strategies, i.e., vaccination only, and vaccination combined with health education. The study has developed an age-structured decision tree model to assess the cost-effectiveness of each of the strategies. Nonetheless, a more comprehensive study can be carried out in the future by considering the country-specific data on vaccine efficacy.

[the_background] =>

In Indonesia, there is no dengue vaccination being introduced yet despite the high morbidity and mortality rates due to dengue infection. Vaccination is potentially the most effective control strategy against dengue. Meanwhile, a Wolbachia program piloted in Yogyakarta has shown promising results. Health education is also important in increasing people’s knowledge and cultivating positive attitudes as well as good practices in preventing dengue. By conducting this study, the output served as valuable information for the government to develop the next initiatives to prevent dengue infection efficiently. Nonetheless, the budget for vaccination has to be ready prior to implementing the findings from this study.

[the_sdg_impact] =>

The outbreak of the recent COVID-19 pandemic has proven that public health is one of the most critical factors in determining the economic growth and sustainability of a country. Thus, it is of utmost importance for the government to prioritize all efforts related to public health. The output of this study has made the calculations easier for the government to plan the next step for preventing and fighting dengue infection. Since the UN aims to strengthen the capacity of all countries for risk reduction of national and global health risks, this study helps to achieve Goal 3: Good Health and Well-being of the UNSDG.

[article_url] => https://www.mdpi.com/1660-4601/17/12/4217 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-39-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Auliya-A.-Suwantika_1615310_1599798543.mp3 [doi] => https://doi.org/10.3390/ijerph17124217 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Cost-Effectiveness of Dengue Vaccination in Indonesia: Considering Integrated Programs with Wolbachia-Infected Mosquitos and Health Education [journal_title] => International Journal of Enviromental Research and Public Health [publisher] => MDPI [year] => June 2020 [subject] => Pharmacology; Clinical ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/IQ-1n4b3W88 [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/40-with-subs-music.mp4_snapshot_00.01_2021.05.12_10.10.50.jpg ) ) [269] => WP_Post Object ( [ID] => 19773 [post_author] => 1 [post_date] => 2020-10-07 04:45:56 [post_date_gmt] => 2020-10-07 04:45:56 [post_content] => [post_title] => Evolution of Feathers: Inspiration for Future Industrial Material Construction [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => evolution-of-feathers-inspiration-for-future-industrial-material-construction [to_ping] => [pinged] => [post_modified] => 2022-08-08 12:45:31 [post_modified_gmt] => 2022-08-08 04:45:31 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19773 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => CHUONG, Cheng-Ming (鍾正明) [researchers_position] => Senior Scientific Advisor, Integrative Stem Cell Center, China Medical University Hospital, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/r2.png [researchers_profile] => https://www.researchgate.net/profile/Chengming_Chuong [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => JUAN, Wen-Tau (阮文滔) [researchers_position_2] => Integrative Stem Cell Center, China Medical University Hospital, Taiwan [researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2020/10/che.png [researchers_profile_2] => https://www.researchgate.net/profile/Wen_Tau_Juan [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Evolution; Development; Stem Cells; Dermal Papilla; Keratin; Composite Biomaterials; Morphogenesis; Branching Morphogenesis; Aamber; Feathered Dinosaurs [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/10/ga-3.png [video] => https://www.youtube.com/embed/ULE8Fc8J0Ns [the_novelty] =>

This research studies the structures of flight feathers via a multi-disciplinary approach focusing on the biological build (bio-architecture) and molecular control of bird feathers. By comparing the evolution of feathers of the past and the present, the advancement of feathers from a simple filamentous appendage into a three-level structure with multi-dimension functionality was observed. Such evolution of the flight mode adaptation displayed both complexification and simplification of structural and material changes. Though contradicting, the transformation was necessary to develop a balanced feather structure for optimum flight performance of different bird groups. The study also summarized bio-architectural principles that have allowed flight feathers to be flexible, adaptable, and functional versatility.

[the_background] =>

Since feathers are crucial for a considerable number of organisms to adapt different flight modes under various eco-space, understanding the bio-architecture principles of different feathers will help in designing flight-based materials with optimal functionality. This study used a newly developed quantitative morphology field analysis (QMorF) to evaluate the biophysical properties of feathers used for different flight characteristics. These quantitative results serve as an important resource to inspire the designs and fabrication of composite materials used for various applications, such as jets, drones, satellites, missiles, and wind turbines.

[the_sdg_impact] =>

The purpose and results of this study contribute significantly to “Goal 9: Industry, Innovation, and Infrastructure” of the UN’s Sustainable Development Goals (SDG). As a requirement for fulfilling this goal, there is a need to upgrade infrastructures and industries to be more sustainable with increased resource-use efficiency. Since efficiency, safety, and automation are the few of the top priorities, the future designs of industrial equipment must not just be advanced but also innovative to meet these priorities. With the in-depth quantitative results and the revealed bio-architectural development from this study, numerous design possibilities offered by nature could be used as inspiration for engineers and innovation experts to rethink flight-based structural builds.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0092867419312292 [main_image] => [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Cheng-Ming-Chuong_1682358_1600143981.mp3 [doi] => https://doi.org/10.1016/j.cell.2019.11.008 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The Making of a Flight Feather: Bio-architectural Principles and Adaptation [journal_title] => Cell Press [publisher] => Elsevier [year] => November 2019 [subject] => Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-21.jpg [figures] => ) ) [270] => WP_Post Object ( [ID] => 19758 [post_author] => 1 [post_date] => 2020-10-07 04:37:48 [post_date_gmt] => 2020-10-07 04:37:48 [post_content] => [post_title] => Anti-breast Cancer Potential of Chisocheton Pentandrus (Blanco) Merr Bark Extract [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => anti-breast-cancer-potential-of-chisocheton-pentandrus-blanco-merr-bark-extract [to_ping] => [pinged] => [post_modified] => 2021-07-19 11:26:15 [post_modified_gmt] => 2021-07-19 03:26:15 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19758 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => SUPRATMAN, Unang [researchers_position] => Department of Chemistry, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/25.jpg [researchers_profile] => https://www.researchgate.net/profile/Unang_Supratman [researchers_second_profile] => https://orcid.org/0000-0003-1104-2321 ) [original_article_reference] => [graphic_abstract] => [video] => [the_novelty] =>

The structural diversity of limonoids extracted from genus Chisocheton has been reported to bring about valuable medical benefits. Intrigued by the richness of compounds found in the stem bark of C. pentandrus plant and their potential therapeutic applications, this study isolated seven limonoids. Each of these compounds was screened for their anticancer activity against MCF-7 breast cancer cells. Out of the seven compounds isolated, three new limonoids were identified (pentandricines B-D), and their chemical structures were determined. When all seven compounds were tested against MCF-7 breast cancer cells, nimonol showed the most promising results of anticancer activity. This is due to its structural uniqueness, which consists of furan ring and acetyl groups.

[the_background] =>

Limonoids from genus Chisocheton are known for their significant biological properties as insecticides, antibacterial, antifungal, antimalarial, antiviral, and anticancer. However, many more compounds naturally present in Chisocheton plants remain undiscovered along with their healing potentials. Therefore, the findings of this study contribute to the growing understanding of the chemical diversity in C. pentandrus extracts, specifically those found in the stem bark. By identifying the structures of the newly discovered pentandricines B-D, future research on the characterization of their functions is made possible. Furthermore, the anticancer activity demonstrated by nimonol against breast cancer provides potential pharmaceutical expansion in treating the disease.

[the_sdg_impact] =>

According to the World Health Organisation (WHO), cancer is the second leading cause of death globally, with breast cancer being the most commonly diagnosed. As much as chemically synthesized drugs are relied upon, naturally occurring compounds from tropical plants, especially from Meliaceae family are recognized as novel sources for many cancer drugs. In line with the UN SDG 3: Good health and well-being targets, this study lays the foundation for developing new and affordable cancer drugs as well as reducing the premature mortality rate caused by cancer.

[research_footprints] => Limonoid; Pentandricine; carbons at δC 157.9; stem bark; correlated to δC 170.0; pentandricine b; breast cancer cell; methyls at δc 19.1; MCF-7; C. pentandrus; carbon at δC 74.4; Cytotoxic activity; type limonoid [article_url] => https://www.sciencedirect.com/science/article/pii/S1874390019304707?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-25-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Unang-Supratman_1136622_1597581498.mp3 [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.1016/j.phytol.2019.11.002 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => New cytotoxic limonoids from the stem bark of Chisocheton pentandrus (Blanco) Merr [journal_title] => Journal of Phytochemistry Letters [publisher] => Elsevier [year] => February 2020 [subject] => Medical; Chemistry ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/1xTDmVh2u8g [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Anti-breast-cancer-potential-of-Chisocheton-pentandrus.mp4_snapshot_00.01_2021.07.16_11.33.58.png ) ) [271] => WP_Post Object ( [ID] => 19745 [post_author] => 1 [post_date] => 2020-10-07 04:10:10 [post_date_gmt] => 2020-10-07 04:10:10 [post_content] => [post_title] => Anti-bacterial and Water-resistant Paint using Silica Nanoparticles [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => anti-bacterial-and-water-resistant-paint-using-silica-nanoparticles [to_ping] => [pinged] => [post_modified] => 2021-07-16 11:19:37 [post_modified_gmt] => 2021-07-16 03:19:37 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19745 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => JONI, I Made [researchers_position] => Department of Physics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/4-1.jpg [researchers_profile] => https://www.researchgate.net/profile/I_Made_Joni [researchers_second_profile] => https://orcid.org/0000-0001-5949-3418 ) [original_article_reference] => [graphic_abstract] => [video] => [the_novelty] =>

This study successfully synthesized amorphous silica nanoparticles through a simple solution method by manipulating the concentration of sodium silicate. By using the beads milling technique and SND 504 dispersing agent, the particle dispersion size and stability were optimized. It was observed that with a 10 wt% SND 504 dispersing agent, the highest water resistance with low critical surface tension was achieved. Also, when tested against Staphylococcus aureus, these dispersed silica nanoparticles showed positive anti-bacterial activity. This study is the first of its kind for using dispersants used in painting applications as an anti-bacterial agent as well. In conclusion, these characterizations proved the potential of the synthesized amorphous silica as an effective filler for painting applications.

[the_background] =>

Silica nanoparticles have gathered the attention of many in recent years due to its wide range of applications, for instance, as catalysts, functional coatings, ceramics, drug delivery and nanomedicine, etc. There is a growing need for a more cost-effective and easier preparation method to mass produce this material without compromising its quality or functions. This study provides proof of cost-effective synthesis of amorphous silica using an economical raw material, sodium silicate, and through an easy technique of optimizing the solution concentration. It also characterizes the material and dispersant to be used to have a better performance in terms of anti-bacterial properties and hydrophobicity. The findings could be used as a foundation of further exploring potential modifications to fit specific requirements in painting applications, or even to improve existing antibiotics delivery in the field of medicine.

[the_sdg_impact] =>

Nanotechnology is the buzzword of this era, with a lot of research and development invested in improving industries like manufacturing, medical, agricultural, etc. This study provides insights into silica nanoparticle synthesis and its functions, which is deemed to be beneficial to enhancing the technological capabilities of industrial sectors worldwide. Hence, aligning its impact along with the targets of the United Nations Sustainable Development Goal 9: Industry, innovation and infrastructure.

[research_footprints] => bacterial activity; Beads milling; Dispersion; zeta potential; silica nanoparticle; Silica; critical surface tension; wt% snd; particle size; Contact angle [article_url] => https://www.sciencedirect.com/science/article/pii/S0921883119303826?via%3Dihub _blank [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/5-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/I-Made-Joni_1092532_1597374764.mp3 [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.1016/j.apt.2019.10.029 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Dispersion of amorphous silica nanoparticles via beads milling process and their particle size analysis, hydrophobicity and anti-bacterial activity [journal_title] => Journal of Advanced Powder Technology [publisher] => Elsevier [year] => January 2020 [subject] => Physics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/XLNQ1KyORBI [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Anti-bacterial-and-water-resistant-paint-using-silica-nanoparticles.mp4_snapshot_00.01_2021.07.16_11.18.18.png ) ) [272] => WP_Post Object ( [ID] => 19735 [post_author] => 1 [post_date] => 2020-10-07 04:02:02 [post_date_gmt] => 2020-10-07 04:02:02 [post_content] => [post_title] => An In-Depth Appreciation of Batik Motifs of Ebeg and Pataruman [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => an-in-depth-appreciation-of-batik-motifs-of-ebeg-and-pataruman [to_ping] => [pinged] => [post_modified] => 2021-08-09 13:39:17 [post_modified_gmt] => 2021-08-09 05:39:17 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19735 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KRISHNAWATI, Ekaning [researchers_position] => Department of Linguistics, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/18.jpg [researchers_profile] => https://www.researchgate.net/profile/Ekaning_Krisnawati [researchers_second_profile] => https://orcid.org/0000-0002-4818-8677 ) [original_article_reference] => [graphic_abstract] => [video] => [the_novelty] =>

As an effort to preserve cultural identity and values, this research has put together a very comprehensive study on how Banjar City in West Java, Indonesia, is exhibiting its identity through batik motifs of Ebeg and Pataruman. Via library research, site visit, interviews and qualitative analysis, an in-depth qualitative discussion was done on the significance behind Ebeg and Pataruman. By applying a similar methodology to study other cultural heritage, the output can be presented in various forms of media to promote culture and tourism extensively.

[the_background] =>

The popularity of batik in Indonesia (esp. in Java) had declined in the 1970s due to several reasons, including the breakdown of a feudal society and the fact that Javanese women sought other careers apart from batik-making. Other than that, the competition caused by batiks from Malaysia and Singapore had also led to such decline. Although Indonesian batik has been acknowledged as an intangible cultural heritage since 2nd October 2009, an effort has to be made to ensure that the values of batik in Indonesia are preserved and developed perpetually. By carrying out this study, the historical and cultural values of the batik motifs of Ebeg and Pataruman could be documented officially and be shared widely.

[the_sdg_impact] =>

According to UNESCO, there are 53 properties (worldwide) listed in the List of World Heritage in Danger as of year 2020, and the list is still expanding each year. With a proper marketing plan, the findings of this research can be used to further improve the tourism sector of Indonesia. By doing so, more job opportunities can be created. Aligned with the UN’s target to devise and implement policies to promote sustainable tourism that creates jobs and promotes local culture and products by 2030, this study helps to realize the Goal 8: Decent Work and Economic Growth of UNSDG.

[research_footprints] => batik; Banjar City; Ebeg; identity; motif; Pataruman; [article_url] => https://journals.sagepub.com/doi/10.1177/2158244019846686 [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Untitled-18-1024x576-1.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Ekaning-Krishnawati_1094217_1597383439.mp3 [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.17576/JKMJC-2020-3601-18 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Identity Exhibition in Batik Motifs of Ebeg and Pataruman [journal_title] => Malaysian Journal of Communication [publisher] => Malaysian Journal of Communication [year] => April 2019 [subject] => Cultural; Linguistics ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/-hS3ijq7zFE [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/39-with-subs-music.mp4_snapshot_00.01_2021.05.12_10.02.53.jpg [figures] => ) ) [273] => WP_Post Object ( [ID] => 19723 [post_author] => 2 [post_date] => 2020-10-07 03:46:56 [post_date_gmt] => 2020-10-07 03:46:56 [post_content] => [post_title] => Combination of Hedyotis Diffusa Willd and Peptide-Based Vaccine as Treatment Strategies Against HPV-related Tumors [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => combination-of-hedyotis-diffusa-willd-and-peptide-based-vaccine-as-treatment-strategies-against-hpv-related-tumors [to_ping] => [pinged] => [post_modified] => 2021-05-11 15:44:59 [post_modified_gmt] => 2021-05-11 07:44:59 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19723 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YEN, Hung-Rong (顏宏融) [researchers_position] => School of Chinese Medicine, China Medical University, Taiwan [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/hungrong.jpg [researchers_profile] => https://www.researchgate.net/profile/Hung_Rong_Yen [researchers_second_profile] => https://orcid.org/0000-0002-0131-1658 ) [original_article_reference] => [graphic_abstract] => [video] => https://www.youtube.com/embed/vg840Xdok3E [the_novelty] =>

Through in vitro and in vivo experimentation, this study presents a novel strategy to treat human papillomavirus (HPV) associated tumors using a peptide-based vaccine supplemented with a Chinese herb extract. Results from this study proved that Hedyotis diffusa Willd (Bai Hua She She Cao, BHSSC) largely improved the peptide vaccine-induced antitumor by enhancing T-cell memory response. The study demonstrated that BHSSC increased activation of mouse and human dendritic cells (DC) and strengthened antigen presentation in bone marrow-derived dendritic cells, which triggered antigen-specific CD8 T-cell immunity. Rutin, an active compound from BHSSC, was found to trigger DC activation and slow down tumor growth, suggesting an involvement in therapeutic and antitumor responses against HPV-related tumors. Results confirmed the combination of BHSSC extract and peptide-based vaccine treatment on HPV-associated cancer could improve specific immune responses, and its independence of the toll-like receptor (TLR) signaling and immunosuppressive factors.

[the_background] =>

Though HPV is widely known as a sexually transmitted infection and, it may also account for certain cancer development. Current vaccines contain capsid protein that blocks specific HPV type viral infection but are useless against virus-infected or cancerous cells. In Asian countries, Chinese Herbal Medicine (CHM) can treat diseases such as tumors, infections, and autoimmune diseases. BHSSC is commonly used and is linked with a range of safe and effective cancer treatment options. However, the role of BHSSC on immune response and healing effect on HPV related cancer is still unclear. Certain vaccines, when combined with an appropriate supplement, can improve immunity and increase vaccine effectiveness. CHM extracts are potential supplementary compounds in vaccines to generate cellular/humoral immune response. As peptide-based vaccination increases vaccine effectiveness and reduces toxicity, the application of CHM may be a safe option. The study found the effectiveness of BHSSC extract as an immune stimulant, and the combination with vaccines increased immunologic activity.

[the_sdg_impact] =>

In the field of cancer research, immunotherapy is a promising and growing field. Cancer vaccines show potential in immunotherapeutic treatments, and the main concern is the ability of the dendritic cells to generate T-cell responses. The combination of herbal adjuvant and the peptide-based vaccine aligns with the goals of goal 3: Good Health and Well-being of Sustainable Development Goal. This novel strategy against virus-associated tumors provides a chance for a better lifestyle and better health for the population.

[research_footprints] => Chinese Herbal Medicine; BHS SC; Dendritic Cells; Bone Marrow-derived Dendritic Cells; Incomplete Freund’s Adjuvant; Immunized with long Peptide; Human Papillomavirus; Polymyxin B; Antigen-presenting Cell [article_url] => https://www.frontiersin.org/articles/10.3389/fimmu.2020.00062/full [main_image] => [podcast] => [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.3389/fimmu.2020.00062 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => A Potential Herbal Adjuvant Combined With a Peptide-Based Vaccine Acts Against HPV-Related Tumors Through Enhancing Effector and Memory T-Cell Immune Responses [journal_title] => Journal of Frontiers in Immunology [publisher] => Frontier [year] => August 2019 [subject] => Medical ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-29.jpg ) ) [274] => WP_Post Object ( [ID] => 19714 [post_author] => 1 [post_date] => 2020-10-07 03:38:08 [post_date_gmt] => 2020-10-07 03:38:08 [post_content] => [post_title] => Adopting Social Media into Local Media Business Model [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => adopting-social-media-into-local-media-business-model [to_ping] => [pinged] => [post_modified] => 2021-08-03 23:55:44 [post_modified_gmt] => 2021-08-03 15:55:44 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19714 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => MARYANI, Eni [researchers_position] => Department of Communication, Universitas Padjadjaran, Indonesia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/10/Ebu-Nartabu.jpg [researchers_profile] => https://www.researchgate.net/profile/Eni_Maryani [researchers_second_profile] => https://orcid.org/0000-0002-4814-8851 ) [original_article_reference] => [graphic_abstract] => [video] => [the_novelty] =>

This case study revealed that local media businesses are starting to adopt and integrate social media platforms as part of their operating model. However, the awareness and ability from their managers to utilize social media is still limited. A few challenges were identified while observing three local media businesses in Indonesia, among which were poor investment of effort, awareness and expectation gap, lack of strategy and leadership, and lack of urgency. By addressing these challenges, this study suggested solutions to how the local media business could leverage social media to expand their audience, strategically utilize the data of their digital audience, and in turn offer these data to the advertisers to increased their revenue.

[the_background] =>

Social media platforms are no more just an avenue for communication; instead, it has also become one of the prominent sources of information, especially for the younger generation. This technological advancement extends its impact on the development of media business. Part of the revenue of media businesses comes from advertisements. But in the Indonesian context, this opportunity is highly dependent on Nielsen’s rating, which often favors the national media. Using social media platforms to disseminate content is one of the ways for local media businesses to level the playing field. Therefore, this study aimed to observe how local media businesses adopt social media into their operations.

[the_sdg_impact] =>

As technology and social media become fully integrated into daily life activities, media businesses, whether local, national, or international, have to improve their information disseminate techniques. By accepting and adapting to the change, companies could effectively engage with the customers or audiences. In this context, local media business could use multiple social media platforms to strengthen their relationships with their existing markets, and simultaneously reach new potential markets. The findings of this case study could be used to create awareness among local media to encourage innovation. Thus, aligning with the aims of UN SDG9: Industry, innovation and infrastructure, to foster innovation, and promote inclusive and sustainable industrialization.

[research_footprints] => APJII; local medium business; social medium platform; media industry; business models; business media; social media; media consumption; Local media [article_url] => http://journalarticle.ukm.my/14493/1/36130-122903-1-PB.pdf [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/10/Adopting-Social-Media.jpg [podcast] => https://iesresearch.solutions/wp-content/uploads/2020/10/Eni-Maryani_1539643_1599472543.mp3 [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.17576/JKMJC-2020-3601-18 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => The Implications of Social Media on Local Media Business: Case Studies in Palembang, Manado, and Bandung [journal_title] => Malaysian Journal of Communications [publisher] => Malaysian Journal of Communications [year] => March 2020 [subject] => Social Science; Communication ) [research_highlights] => Array ( [youtube_link] => https://www.youtube.com/embed/wQbcJN_UW3I [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2020/10/Adopting-social-media-into-local-media-business-model.mp4_snapshot_00.01_2021.08.03_23.53.26.png [figures] => ) ) [275] => WP_Post Object ( [ID] => 19517 [post_author] => 2 [post_date] => 2020-09-21 10:12:47 [post_date_gmt] => 2020-09-21 10:12:47 [post_content] => [post_title] => Potential GHG Emissions Reduction via Integrated Waste Management System [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => potential-ghg-emissions-reduction-via-integrated-waste-management-system [to_ping] => [pinged] => [post_modified] => 2022-07-08 10:44:20 [post_modified_gmt] => 2022-07-08 02:44:20 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19517 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YUSOFF, Sumiani [researchers_position] => University of Malaya | UM · Department of Civil Engineering [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/09/suhaimi.png [researchers_profile] => https://www.researchgate.net/profile/Sumiani_Yusoff [researchers_second_profile] => ) [original_article_reference] => [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/09/2a1-600x363-1.png [video] => [the_novelty] =>

This study shares an innovative approach to transform the existing linear economy into a circular economy through the improvement of waste management system. The greenhouse gases (GHGs) emission reduction potential is evaluated via composting of source-separated organic waste (SOW) in municipal solid waste within University of Malaya (UM) vicinity. The results are intended to increase awareness on the benefits of integrated solid waste management system and the reduction of global warming through waste prevention strategies worldwide. This study could also serve as a guideline for policymakers in enforcing a better waste management system.

[the_background] =>

In response to the issues of solid waste management in campus, the initiation of the Zero Waste Campaign aims to divert and reduce waste generated from going to the landfills. The adaptation of an integrated waste management system includes recycling, waste treatment and waste to energy conversion. Ultimately, this approach intends to contribute to the improvement of resource conservation, protection of environment and human health.

[the_sdg_impact] =>

A research in 2016 concluded that 2.01 billion tonnes of municipal solid waste was generated in cities worldwide. With the rate of urbanization and population growth the world is experiencing, the annual waste generated is expected to see no reduction. The threats of unsustainable waste management are real especially in developing countries and low-income countries due to unregulated waste disposal methods and open burning. Thus, it is believed that by noticing the importance of integrated waste management system, it will lead to an awareness of how environmental burden can be reduced and ways to promote responsible waste disposal. This is also in line with UN’s twelfth Sustainable Development Goal which is ensuring sustainable consumption and production pattern in the long run.

[research_footprints] => Composting; GHG; Kitchen Waste; SOW; Waste Management; Yard Waste [article_url] => http://www.ukm.my/jsm/pdf_files/SM-PDF-44-02-2015/05%20Chee%20Guan%20Ng.pdf [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/09/photo-1516992654410-9309d4587e94-768x512-1.png [podcast] => [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.17576/jsm-2015-4402-05 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Assessment of GHG Emission Reduction Potential from Source-separated Organic Waste (SOW) Management: Case Study in a Higher Educational Institution in Malaysia [journal_title] => Sains Malaysiana [publisher] => Penerbit Universiti Kebangsaan Malaysia (UKM Press). [year] => February 2015 [subject] => Studies in Human Society ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) [276] => WP_Post Object ( [ID] => 19511 [post_author] => 2 [post_date] => 2020-09-21 10:05:48 [post_date_gmt] => 2020-09-21 10:05:48 [post_content] => [post_title] => Aprotic Ionic Liquids: Green Lignin Extraction Technique [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => aprotic-ionic-liquids-green-lignin-extraction-technique [to_ping] => [pinged] => [post_modified] => 2021-07-19 14:49:50 [post_modified_gmt] => 2021-07-19 06:49:50 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19511 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ALIAS, Yatimah [researchers_position] => University of Malaya | UM · Department of Chemistry [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/09/download-1-231x300-1.png [researchers_profile] => https://iesresearch.solutions/wp-content/uploads/2020/04/rcf.png [researchers_second_profile] => ) [original_article_reference] => [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/09/coconut-600x397-1.png [video] => [the_novelty] =>

This study emphasises on introducing a greener lignin extraction process from coconut shell through the usage of aprotic ionic liquids. By manipulating the cations and anions ratio of [Emim][Ace], 10% of regenerating lignin was obtained from a two-hour treatment at 150oC, proving a higher yield production compared to other ionic liquids tested. The unique ability of the solvent to be recycled up to four times and to enhance the biomass pre-treatment processes serve as a game-changer in biowaste management system.

[the_background] =>

Existing lignin extraction processes are known to use harsh solvents and harsh conditions, leading to low-value product conversion and worse still, environmental pollution. The tuneable nature of ionic liquids and known capacity in dissolving organic biomass makes it a desirable solvent media in bio-transformations. By extracting lignin from biomass using ionic liquids proves to be inexpensive, greener and cleaner with no toxic or odorous gases emission as a byproduct of the process.

[the_sdg_impact] =>

Introduction of aprotic ionic liquids into biomass treatment is important to the sustainability of chemical industry to due the potential generation of a number of valuable chemical feedstock. In line with UN’s Sustainable Development Goal 7, the conversion of lignocellulosic biomass into bioproducts could potentially reduce the dependence on fossil fuels, allowing access to affordable and sustainable energy, especially for developing countries like Brazil, Philippines, India, Indonesia, Malaysia and Sri Lanka.

[research_footprints] => Ionic liquids; Biomass; Lignocellulosics; Lignin; Coconut shell [article_url] => https://ojs.cnr.ncsu.edu/index.php/BioRes/article/view/BioRes_12_3_5749_Zakaria_Lignin_Extraction_Coconut_Shell [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/09/photo-1509685446001-c340df69aa67-768x512-1.png [podcast] => [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.15376/biores.12.3.5749-5774 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Lignin Extraction from Coconut Shell Using Aprotic Ionic Liquids [journal_title] => BioResources [publisher] => BioResources [year] => June 2017 [subject] => Resources Engineering and Extractive Metallurg ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [277] => WP_Post Object ( [ID] => 19505 [post_author] => 2 [post_date] => 2020-09-21 10:00:05 [post_date_gmt] => 2020-09-21 10:00:05 [post_content] => [post_title] => Biohydrogen and Biomethane Production from Palm Oil Wastewater Treatment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => biohydrogen-and-biomethane-production-from-palm-oil-wastewater-treatment [to_ping] => [pinged] => [post_modified] => 2021-07-19 13:02:59 [post_modified_gmt] => 2021-07-19 05:02:59 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19505 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => IBRAHIM, Shaliza [researchers_position] => University of Malaya | UM · Department of Civil Engineering [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/09/download-10.jpg [researchers_profile] => https://www.researchgate.net/profile/Shaliza_Ibrahim [researchers_second_profile] => ) [original_article_reference] => [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/09/shaliza-600x397-1.png [video] => [the_novelty] =>

This is a start-up study examining the behaviour and performance of palm oil mill effluent in the production of biohydrogen and biomethane gases. Factors such as process stability and biogas production are considered in the conversion of palm oil discharge using a two-stage up-flow anaerobic sludge fixed film (UASFF) bioreactor. In addition to the conventional methane production, this research provides an efficient method of palm oil wastewater treatment with a higher value output of hydrogen gas production. With the support of industries and government, this research could serve as a golden standard in palm oil waste treatment as well as be implemented as part of a sustainable approach in various industrial organic waste management system.

[the_background] =>

The rapidly diminishing energy source has imposed a growing demand on resource conservation and green energy production initiatives. Apart from utilizing methane as an organic byproduct to generate energy, hydrogen gas production via industrial wastewater treatment promises a cleaner energy source. The outcome of this research could be used as a technical basis for the development of larger-scale prototype design of UASFF to produce biohydrogen and biomethane gases from palm oil discharge treatment.

[the_sdg_impact] =>

Anaerobic treatment is a well-established technology for treatment of wastes and wastewaters as it is technologically simple with a low energy consumption workflow. Moreover, it is an efficient, economical and environmental-friendly method. The final product of anaerobic digestion is biogas, a mixture of methane and hydrogen, which could potentially be leveraged in the form of renewable energy source. In compliance to the UN’s Sustainable Development Goals, this research aims to fulfil the following:
Goal 6: Ensure availability and sustainable management of water and sanitation for all
Goal 7: Ensure access to affordable, reliable, sustainable and modern energy for all

[research_footprints] => Biohydrogen; Biomethane; Palm Oil Mill Effluent; UASFF [article_url] => https://www.sciencedirect.com/science/article/abs/pii/S1357272518301286?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2020/09/khLPhykbRGiQmBGR4V6K__DSC1730-768x495-1.png [podcast] => [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.1016/j.ijhydene.2018.07.037 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => UASFF start-up for biohydrogen and biomethane production from treatment of palm oil mill effluent [journal_title] => International Journal of Hydrogen Energy [publisher] => Elsevier [year] => August 2019 [subject] => Engineering; Chemical Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [278] => WP_Post Object ( [ID] => 19500 [post_author] => 2 [post_date] => 2020-09-21 09:50:53 [post_date_gmt] => 2020-09-21 09:50:53 [post_content] => [post_title] => Virtual Reality Based Aerospace Composite Panel Drilling Training System [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => virtual-reality-based-aerospace-composite-panel-drilling-training-system [to_ping] => [pinged] => [post_modified] => 2021-05-11 15:50:11 [post_modified_gmt] => 2021-05-11 07:50:11 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19500 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => YAP, Hwa-Jen [researchers_position] => University of Malaya | UM · Department of Mechanical Engineering [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/09/researchers-image01.jpg [researchers_profile] => https://www.researchgate.net/profile/Hwa_Jen_Yap2 [researchers_second_profile] => ) [original_article_reference] => [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/09/669-600x397-1.png [video] => https://www.youtube.com/embed/dYigKsM12ec [the_novelty] =>

This study aims to introduce a viable alternative training technique in the drilling of aerospace-grade CFRP panels by developing a virtual reality (VR) system. The traditional training system in the drilling of aerospace-grade CFRP panels requires many resources, including time, materials, tools, and instructors. The proposed VR system mainly consists of a Realistic Human Ergonomics Analysis (RHEA), a 6D haptic device, motion trackers, a 3D Power Wall system, and 3D projectors. Based on several critical parameters involved in the actual drilling, the VR system can accurately rate the performance of a particular technician. Hence, the system is statically proven to be feasible in training beginners to master the essential skills in the drilling of aerospace-grade CFRP.

[the_background] =>

In the aerospace industry, precision is crucial as failure means loss of precious lives and costly equipment. Despite having automated drilling systems to perform precise drilling, human expertise is still irreplaceable, especially in performing a proper angled drilling on irregular-shaped larger aircraft panels. Therefore, training is still needed to help technicians to master proper drilling techniques, especially to drill with the right thrust force. It is essential to stay within the acceptable range of several critical parameters like maximum overshoot, time taken to penetrate, and maximum opening of blocks. In order to enhance the skill set of the technicians while keeping the cost at bay, a VR system has been developed through this study. It is capable of training a beginner driller to become an expert.

[the_sdg_impact] =>

This study aims to achieve “Goal 9: Industry, Innovation and Infrastructure” of the UN’s Sustainable Development Goals (SDG). Air travel is becoming more common than ever in order to cater to the increase in demand for both commercial and non-commercial. This implies that keeping up with the quality and maintenance of aircraft is bound to be a challenge. To address this matter practically, improvements have to be done to increase the efficiency of the manufacturing line of aircraft. The studied VR system shows promising results in producing highly-qualified drilling technicians, and the same concept can be implemented in the necessary part of the manufacturing line.

[research_footprints] => Aerospace; CFRP; Drilling; Haptic; Performance; Skill-demanding; Training; Virtual reality (VR); Computer Aided Design; General Linear Model; Composites; Carbon fiber Reinforced Polymers; Realistic Human Ergonomics Analysis; Significant Difference; Advanced Realtime Tracking [article_url] => https://www.sciencedirect.com/science/article/pii/B9780081022917000071?via%3Dihub [main_image] => [podcast] => [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.1016/b978-0-08-102291-7.00007-1 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Haptic-based virtual reality system to enhance actual aerospace composite panel drilling training [journal_title] => Woodhead Publishing Series in Composites Science and Engineering [publisher] => Elsevier [year] => January 2019 [subject] => Engineering ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/Virtual-Reality-Based-Aerospace-Composite-Panel-Drilling-Training-System.mp4_snapshot_00.01_2021.05.11_10.29.30.jpg ) ) [279] => WP_Post Object ( [ID] => 19402 [post_author] => 1 [post_date] => 2020-09-09 05:33:51 [post_date_gmt] => 2020-09-08 21:33:51 [post_content] => [post_title] => Banana Cell Suspension Culture Technique Comparison [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => banana-cell-suspension-culture-technique-comparison [to_ping] => [pinged] => [post_modified] => 2021-06-08 10:43:56 [post_modified_gmt] => 2021-06-08 02:43:56 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=19402 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => KHALID, Norzulaani [researchers_position] => University of Malaya | UM · Department of Biology [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2020/09/Norzulaani_Khalid-150x150-1.jpg [researchers_profile] => [researchers_second_profile] => ) [original_article_reference] => [graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2020/09/gabanana.png [video] => https://www.youtube.com/embed/SEC3mVxdhLQ [the_novelty] =>

This study aims to upscale the production of superior quality banana plants through embryogenic cell cultures using modern bioreactors. The utilization of bioreactor showed a prominent increase in cell suspension cultures within 14 days compared to the conventional shake flask culturing technique. The flexibility in manipulating a wide range of parameters to optimize plant growth conditions is more convenient with the adaptation of bioreactor culturing techniques. This new method introduced promises an efficient and less labor-intensive mass production of banana plants, suitable for commercial laboratories.

[the_background] =>

Conventional banana propagation technique using field-collected suckers or corms are not just slow in production but are also susceptible to transmission of numerous diseases from the original plant. The yield also lacks consistency in growth traits and quality depending on the individual suckers propagated. Embryogenic cell culture as an alternative ensures a low percentage of genetic variation, allowing the superior quality of plant and fruit to be retained from the mother plant. This research focuses on mass-producing prime banana plants through the adaptation of bioreactor, overcoming the limitations of conventional plant tissue culture methods.

[the_sdg_impact] =>

Banana is the world’s most popular fruit, and in Malaysia, banana accounts for 24% of the total fruit production. In line with the UN’s second Sustainable Development Goal, to end hunger, achieve food security and improved nutrition, and promote sustainable agriculture, agricultural productivity could be raised through the innovation of new plantation techniques. Superior and disease-free planting materials are obtained through tissue culture technique, but the current practice is inefficient and fails to meet the market demand. Hence, the embryogenic culture is a promising alternative to increase and improve the production of not just bananas, but also has the potential for other plant species.

[research_footprints] => Bioreactor; Cell suspension; Banana; Somatic embryogenesis; Peroxidase; Catalase; Murashige and Skoog; Shake Flask; Superoxide Dismutase; Cell Growth; Balloon Type Bubble Column Bioreactor; Reactive Oxygen Species [article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0304423814001800 [main_image] => [podcast] => [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [doi] => https://doi.org/10.1016/j.scienta.2014.03.042 [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [original_article_reference_fields] => Array ( [publication_title] => Evaluation of a laboratory scale conventional shake flask and a bioreactor on cell growth and regeneration of banana cell suspension cultures [journal_title] => Scientia Horticultura [publisher] => Elsevier [year] => June 2014 [subject] => Food Science ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => https://iesresearch.solutions/wp-content/uploads/2021/03/maxresdefault-39.jpg ) ) [280] => WP_Post Object ( [ID] => 29016 [post_author] => 154 [post_date] => 2020-02-19 15:16:33 [post_date_gmt] => 2020-02-19 07:16:33 [post_content] => [post_title] => Benzimidazole Derivatives as Potential Cancer Inhibitors [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => benzimidazole-derivatives-as-potential-cancer-inhibitors [to_ping] => [pinged] => [post_modified] => 2021-07-19 15:23:46 [post_modified_gmt] => 2021-07-19 07:23:46 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29016 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => ABDULLAH, Iskandar [researchers_position] => Department of Chemistry, University Malaya, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/07/iskandar.png [researchers_profile] => https://www.researchgate.net/profile/Iskandar-Abdullah [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Poly (ADP-ribose) polymerase; PARP; PARP-1; Dihydroorotate dehydrogenase; DHODH; Benzimidazole [graphic_abstract] => [video] => [the_novelty] =>

This research focuses on synthesizing and understanding the bioactivities of new benzene-imidazole fused-ring molecules and a series of benzimidazole derivatives. The molecules of interest portray potential inhibition properties for both PARP-1 and DHODH enzymes, which could benefit new anti-cancer agents designing. It could also serve as a contributor to drug designing and development by providing a platform for the construction of organic molecules. The synthesis of new molecules utilizing organic reactions could provide a theoretical basis to elaborate biological experimentation. This research mainly targets those cancer patients with BRCA-2 deficiency. Support from the cancer society, physicians, funding from the ministry, and clinicians are needed for the progress of this research.

[the_background] =>

Chemotherapy treatment kills both cancerous and healthy cells, and it works throughout the whole body. There is a need for a better alternative with lesser side effects for cancer patients. Therefore, the discovery and development of potent, selective, and safe drugs are crucial. Benzimidazole derivatives possess good pharmacological and antitumor activity, including PARP and DHODH inhibition. Understanding the mechanisms of PARP-1 and DHODH enzymes in DNA replication and repair mechanisms involved in the hyper-proliferation of cancer cells and targeting the activity of these enzymes for anti-cancer therapy would be beneficial.

[the_sdg_impact] =>

Cancer is a leading cause of death worldwide, and breast cancer accounts for 2.09 million cases. Treatment option for breast cancer usually comprises of surgery, chemotherapy and radiation therapy. Computational chemistry plays a role in drug design and discovery by identifying drug binding to its target and the chemical properties for designing potential new drugs. This machine learning method can accelerate the identification and design of potential new drugs for cancer treatment. This research provides a better insight into new drug development, and it aims to ensure healthy lives and promote well-being for all at all ages, which is in line with the UN’s third Sustainable Development Goal. Further research is needed to address the development and implication of machine learning towards effective cancer treatment.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0968089615004733?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/07/iskandar2.jpg [podcast] => [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.bmc.2015.05.051 [original_article_reference_fields] => Array ( [publication_title] => Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH [journal_title] => Bioorganic & Medicinal Chemistry [publisher] => Elsevier [year] => August 2015 [subject] => Medicinal and Biomolecular Chemistry; Organic Chemistry ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => ) ) [281] => WP_Post Object ( [ID] => 29002 [post_author] => 154 [post_date] => 2020-02-19 15:03:01 [post_date_gmt] => 2020-02-19 07:03:01 [post_content] => [post_title] => Biomass Oil into Biofuel: A Catalytic Conversion [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => open [post_password] => [post_name] => biomass-oil-into-biofuel-a-catalytic-conversion [to_ping] => [pinged] => [post_modified] => 2022-01-03 11:58:53 [post_modified_gmt] => 2022-01-03 03:58:53 [post_content_filtered] => [post_parent] => 0 [guid] => https://iesresearch.solutions/?post_type=ieresearch&p=29002 [menu_order] => 0 [post_type] => ieresearch [post_mime_type] => [comment_count] => 0 [filter] => raw [acf_fields] => Array ( [researchers_info] => Array ( [researchers_name] => LEE, Hwei Voon [researchers_position] => Nanotechnology & Catalysis Research Centre, University Malaya, Malaysia [researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/07/lee.png [researchers_profile] => [researchers_second_profile] => ) [researchers_info_2] => Array ( [researchers_name_2] => [researchers_position_2] => [researchers_photo_2] => [researchers_profile_2] => [researchers_second_profile_2] => ) [original_article_reference] => [research_footprints] => Deoxygenation; Mesoporous silica; Silica-alumina; Non-edible oil; High free fatty acid; Biofuel [graphic_abstract] => [video] => [the_novelty] =>

This research proves that the Co-Ca loaded SiO2-Al2O3 is a viable catalyst in the deoxygenation (DO) process which produces hydrocarbon-based green diesel. The researchers managed to confirm the efficiency of silica-alumina (SA) supported NiO-CaO deoxygenizing triglycerides-based feedstock in a previous study. However, the SA catalyst is not coke-resistant. In the present study, the researchers used the aforementioned mesoporous acid-base catalyst which proves to yield higher and more consistent DO activity. The formation of coke is still reported in this study due to the usage of non-edible oil with high content of unsaturated alkyl fatty acid.

[the_background] =>

This study is bound to improve the biomass conversion process (deoxygenation) of high selectivity hydrocarbon-based biofuel. The progress of the biomass conversion process potentially signifies that the production of quality green diesel can be done in a more economically friendly and less complex manner. Undoubtedly, advancement in this area may offer a sustainable alternative to fossil fuel, preventing depletion of natural resources and resolving the energy crisis.

[the_sdg_impact] =>

With the ever-growing threat of climate change, biofuel is a potential deal-breaker that could help attenuate the backlash caused by the depletion of fossil fuels. Pure biodiesel is not applicable due to various reasons which beckons the need for catalytic processes such as deoxygenation. Deoxygenation is viewed as a much better option as it is a highly sustainable and cost-effective procedure. Researchers are working to improve and perfect the deoxygenation/ biomass conversion process in the hopes of achieving UN’s seventh Sustainable Development Goal of creating affordable, clean energy.

[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0926860X17305756?via%3Dihub [main_image] => https://iesresearch.solutions/wp-content/uploads/2021/07/lee-3.jpg [podcast] => [podcast_chat_1] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_2] => Array ( [podcast_title] => [podcast_chat_file] => ) [podcast_chat_3] => Array ( [podcast_title] => [podcast_chat_file] => ) [doi] => https://doi.org/10.1016/j.apcata.2017.12.020 [original_article_reference_fields] => Array ( [publication_title] => Promoting deoxygenation of triglycerides via Co-Ca loaded SiO2-Al2O3 catalyst [journal_title] => Applied Catalysis A: General [publisher] => Elsevier [year] => February 2018 [subject] => Chemical Sciences ) [research_highlights] => Array ( [youtube_link] => [youku_link] => ) [research_highlights_video_thumbnail] => [figures] => ) ) )

Evolution of Feathers: Inspiration for Future Industrial Material Construction

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