A Newly Identified DNA Repair Switch Drives Resistance to PARP Inhibitors in Breast Cancer

Post Views: 112 A Newly Identified DNA Repair Switch Drives Resistance to PARP Inhibitors in Breast Cancer Targeted cancer therapies are designed to exploit specific weaknesses in tumor cells. One such treatment, PARP inhibitors, has transformed care for patients with breast cancers carrying BRCA mutations. These drugs work by blocking a DNA repair protein called…

Lithium-Enhanced Bone Scaffold Promotes Immune-Guided Bone Regeneration

Post Views: 126 Lithium-Enhanced Bone Scaffold Promotes Immune-Guided Bone Regeneration Repairing damaged bone is not simply a matter of filling a structural gap. Successful bone healing depends on a carefully orchestrated interaction between immune cells, blood vessels, and bone-forming cells. When bone is injured, immune cells such as macrophages arrive first. Initially, they trigger inflammation…

Engineered Hydrogel Enhances Diabetic Wound Healing by Modulating Immune Response

Post Views: 107 Engineered Hydrogel Enhances Diabetic Wound Healing by Modulating Immune Response Chronic wounds are among the most challenging complications faced by people living with diabetes. Unlike normal injuries that heal in a predictable sequence, diabetic wounds often remain trapped in prolonged inflammation. Poor blood circulation, oxidative stress, and impaired collagen formation prevent proper…