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[post_title] => High-Accuracy Mortality Evaluation by 24-h Urine Creatinine Excretion Rate Adjustment
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[post_date] => 2022-08-15 14:58:51
[post_date_gmt] => 2022-08-15 06:58:51
[post_content] =>
[post_title] => Unveiling the Binding Mode between Bacterial STING & c-di-GMP
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[post_name] => unveiling-the-binding-mode-between-bacterial-sting-c-di-gmp
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[researchers_name] => CHEN, Yeh (陳曄)
[researchers_position] => Institute of New Drug Development, China Medical University, Taiwan
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[research_footprints] => crystal structure; molecular replacement; pathogen-associated molecular patterns; isothermal titration calorimetry; E. coli; multi-wavelength anomalous dispersion
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => Upon identifying two complex crystal structures of bacterial STING/c-di-GMP, this study reveals the precise binding mode of c-di-GMP to the bacterial STING. The findings clarify how bacterial STING differentiates c-di-GMP second messengers from other cyclic dinucleotides during viral infections. Besides that, the interaction between bacterial STING and c-di-GMP is found to be accountable for the oligomerization of the former into long filament. According to the oligomerization mechanism and ligand specificity, the bacterial STING is categorized into Class I and II. Since mammalian STING protein originated in bacteria, the output of this study provides valuable insights in the innate immunity of human.
[the_background] => Stimulator of interferon gene (STING) is a crucial immune sensor which, during viral infection, triggers self-destruction of infected cells in order to contain the infection. Although the signaling pathway is initiated by the binding between STING and c-di-GMP, the exact binding mode of c-di-GMP to bacterial STING and the specific recognition mechanism remain vague. Thus, this study is carried out to investigate the mechanism by determining the crystal structures of bacterial STING/c-di-GMP. It also proposes that Class II bacterial STING, which recognizes 3’3’-cGAMP more favorably, is in the evolutionary transition from c-di-GMP-dependent signaling in bacteria to 2’3’-cGAMP-dependent signaling in eukaryotes. Other than facilitating future STING-related studies, this research complements the existing knowledge base for human’s innate immune signaling.
[the_sdg_impact] => STING plays an important role in innate immunity as an essential mediator and inducer. Thus, to speed up the advance of research related to human immune system, a more in-depth understanding of mammalian STING protein (which originated in bacteria) is required. By shedding light on the crucial mechanisms involved in human immune system, this study fulfils UNSDG 3: Good Health & Well-Being.
[article_url] => https://www.nature.com/articles/s41467-021-26583-3
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[publication_title] => Crystal structure and functional implication of bacterial STING
[journal_title] => Nature Communications
[publisher] => Springer Nature
[year] => January 2022
[subject] => Medical; Drug Development
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[post_date] => 2022-08-07 20:44:00
[post_date_gmt] => 2022-08-07 12:44:00
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[post_title] => Role of Exosomal PD-1 in Anti-Tumor Activity and Attenuation of Immune Suppression
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[researchers_name] => HUNG, Mien-Chie (洪明奇)
[researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan
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[research_footprints] => tumor cell; immune checkpoint; T lymphocyte; effector T cell; triple negative breast cancer; tumor infiltrating lymphocyte; t cell; Triple-negative breast cancer; transmission electron microscopy; extracellular vesicles; Programmed cell death 1; programmed death-ligand 1; cell death; tumor-infiltrating lymphocytes
[graphic_abstract] =>
[figures] =>
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[the_novelty] => This study discovered the potential of exosomal membrane-bound PD-1 (Exo-PD-1) in enhancing the cytotoxic activity of T cells against tumor cells and, simultaneously, attenuating immune suppression in triple-negative breast cancer (TNBC). Upon activation, Exo-PD-1 released by T cells were actively involved in two modes of PD-L1-blockade anti-tumor action, i.e. remotely binding to exosomal PD-L1 and directly binding to PD-L1 on tumor-cell surface. The Exo-PD-1 binding on the tumor-cell surface induced clathrin-mediated endocytosis (CME) of PD-L1. Other than creating an entry point for Exo-PD-1 to enter the TNBC cells, CME of PD-L1 also reduced the amount of surface PD-L1 available during subsequent direct interaction between T cells and tumor cells. The protective role of Exo-PD-1 against the anti-tumor immune dysfunction induced by PD-L1 in TNBC has been confirmed by in vitro and in vivo studies. As part of the expansion of research scope, future studies ought to examine whether the tumor-infiltrating lymphocytes (TILs) markers of T cell apoptosis and exhaustion are contained by T cell-derived exosomes, and whether they bear similar immune function to that of Exo-PD-1 in fighting tumor.
[the_background] => Programmed cell death protein 1 (PD-1) is a protein on the surface of T and B cells. Although PD-1 is essential in preventing autoimmune diseases, it also prevents cancer cells from being killed. In contrast, the expression of PD-1 showed positive correlation to the survival rate of patients with triple-negative breast cancer (TNBC). These contradicting yet intriguing observations made scientists wondered if the PD-1 on T cells comprises uncovered potential associated to the inhibition of cancer cells. Meanwhile, past studies also reported that exosomes derived from T lymphocytes were involved in the regulation of immune reaction. Upon investigating the role of T cells-derived exosomes in suppressing TNBC, this research elucidated how exosomal PD-1 protects against the anti-tumor immune dysfunction induced by PD-L1 in TNBC. Notably, this discovery may lead to the development of therapeutic strategies which enhance cytotoxic activity against tumor cells and attenuate immune suppression simultaneously.
[the_sdg_impact] => As long as cancers exist, 10 million lives are lost globally each year and this number can be lowered only by more effective therapeutic strategies. With the proven potential of Exo-PD-1 in treating triple-negative breast cancer (TNBC), promising cancer therapies can be developed based on the modification of exosome surface. Moreover, the discovery of this study also proves the importance of immune suppression attenuation in fighting cancers (UNSDG 3: Good Health & Well-Being).
[article_url] => https://www.nature.com/articles/s41388-021-01896-1
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Suppression.jpg
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[doi] => https://doi.org/10.1038/s41388-021-01896-1
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[publication_title] => Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer
[journal_title] => Oncogene
[publisher] => Springer Nature
[year] => June 2021
[subject] => Medical; Cancer; Immunity
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[post_date] => 2022-08-07 20:32:29
[post_date_gmt] => 2022-08-07 12:32:29
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[post_title] => Osteoblastic Prostate Cancer Migration Suppressed by Melatonin
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[post_name] => osteoblastic-prostate-cancer-migration-suppressed-by-melatonin
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[researchers_name] => TANG, Chih‐Hsin (湯智昕)
[researchers_position] => Department of Pharmacology, School of Medicine, China Medical University, Taiwan
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[research_footprints] => Quantitative real‐time polymerase chain reaction; integrin; advanced prostate cancer; lung cancer; Gleditsia sinensis; Fluorescein isothiocyanate; G‐protein coupled receptor; metastatic; protein kinase C; messenger RNA
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study reported the pathway underlying how melatonin suppresses the metastatic potential of osteoblastic prostate cancer. The pathway started with the binding of melatonin to MT1 receptor which was crucial in conveying the downstream effects of melatonin. After that, the phosphorylation of FAK, c‐Src and NF‐κB was decreased, inhibiting the integrin α2β1 expression as well as osteoblastic prostate cancer migration. The pathway was revealed via in vitro studies using osteoblastic prostate cancer cell line C4‐2. Preclinical trials can be carried out in the future to explore the possibilities of developing a cancer therapy based on this discovery.
[the_background] => Prostate cancer has been identified as a cause of osteoblastic bone metastasis. This indicated that patients with prostate cancer are also facing a high risk of metastatic bone disease. Meanwhile, strong evidence implied the direct involvement of receptors integrins α2β1 in prostate cancer bone metastasis due to their potential in prostate cancer cell progression, migration, and invasion. On the other hand, besides exhibiting antitumor activity, melatonin was actively involved in antimetastatic activity in osteolytic prostate cancer cells as well as osteoclastogenesis inhibition. However, the potential and mechanism of melatonin in inhibiting the migratory and invasive properties of osteoblastic prostate cancer cells remain ambiguous. Thus, this study aimed to investigate the underlying mechanism of how melatonin hinders the motility human prostate cancer cells and the metastatic in osteoblastic prostate cancer cells. The findings confirmed the therapeutic potential of melatonin for prostate cancer bone metastases, paving a path to the design of high-efficacy therapeutic strategies.
[the_sdg_impact] => Metastatic bone disease is a severe collateral damage due to cancers and 84% of deaths were due to prostate cancer. There are approximately 268,000 new cases of prostate cancer reported yearly in United States, indicating the high risks of metastatic bone disease. Hence, while focusing on cancer therapies, attention should also be allocated to the treatment of metastatic bone. By demonstrating the efficacy of melatonin in inhibiting the metastatic potential of osteoblastic prostate cancer, this study fulfils UNSDG 3: Good Health & Well-Being.
[article_url] => https://onlinelibrary.wiley.com/doi/10.1111/jpi.12793
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[publication_title] => Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression
[journal_title] => Journal of Pineal Research
[publisher] => Wiley Publishing
[year] => February 2022
[subject] => Medical; Metastatic Bone Disease; Melatonin
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[post_date] => 2022-08-07 14:09:59
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[post_title] => Treating Psychiatric Disorders and Type 2 Diabetes through Their Comorbidity
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[post_name] => treating-psychiatric-disorders-and-type-2-diabetes-through-their-comorbidity
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[researchers_name] => WANG, Shi-Heng (王世亨)
[researchers_position] => Interdisciplinary Freshmen Program of Public Health, China Medical University, Taiwan
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[research_footprints] => psychotic disorder; environmental factor; Depression; Adjusted odds ratio; genome-wide association study; Diabetes; Principal component; Comorbidity; East Asian population; family history; linkage disequilibrium
major depressive disorder; polygenic risk score; bipolar disorder; familial aggregation; schizophrenia; Psychiatric Genomics Consortium
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => Based on a cohort of 105,184 participants, this study disclosed the underlying mechanisms of the comorbidity between psychiatric disorders and type 2 diabetes. A family history of type 2 diabetes was associated with family history of all three common psychiatric disorders i.e. schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD). Compared to paternal type 2 diabetes, maternal type 2 diabetes demonstrated a higher strength of association with SCZ family history, indicating that women demonstrate a more predominant effect of family history of type 2 diabetes on SCZ than men. Higher genetic loading for SCZ was associated with a lower risk of type 2 diabetes in women but not in men. This suggests that gender could potentially alter the genetic effect on human diseases. On the other hand, higher genetic loading for MDD was associated with a higher risk of type 2 diabetes. Although familial aggregation was reported between type 2 diabetes and BPD, there is a lack of a polygenic association between them probably due to a role of environmental factors in the mechanisms. Results also showed that the polygenic effect of SCZ on type 2 diabetes may be partly mediated by obesity and the polygenic effect of MDD on type 2 diabetes may be partly mediated by obesity or smoking. Future studies may replicate this approach on participants of other ancestries (besides Taiwanese) to explore the outcomes.
[the_background] => The comorbidity between psychiatric disorders and type 2 diabetes has been proven and this implied the importance to examine its underlying mechanism. Moreover, the familial aggregation of type 2 diabetes and common psychiatric disorders also suggested an influence of shared environmental factors or genetic background. Further studies showed that the association was mainly due to genetic background, especially in female. Meanwhile, the influence of sex differences was highlighted through the difference in prevalence of type 2 diabetes in the mothers and fathers of those with psychosis. Hence, this study investigated the underlying mechanisms of the comorbidity between psychiatric disorders and type 2 diabetes by examining familial aggregation and testing for polygenic overlap based on a molecular approach. For the first time, polygenic loading was applied for common psychiatric disorders to predict type 2 diabetes in Asia with the largest sample size to-date. The output provides crucial insights indicating the needs for therapies and preventive plans to address the initial development of type 2 diabetes and its comorbidity with psychiatric disorders.
[the_sdg_impact] => Comorbidity is associated with degrading health, higher complexity clinical management, and higher health care costs. Based on the proven comorbidity between psychiatric disorders and type 2 diabetes, depression should be diagnosed and treated proactively as the physical complications of diabetes that are commonly prioritized. This will directly lower the number of cases for both depression and type 2 diabetes. By understanding the underlying mechanisms of the comorbidity, high-efficacy therapeutic strategies can be planned to lower the risks for both diseases (UNSDG 3: Good Health & Well-Being).
[article_url] => https://link.springer.com/article/10.1007/s00125-022-05665-x
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/Comorbidity.jpg
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[publication_title] => Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes
[journal_title] => Diabetologia
[publisher] => Springer Nature
[year] => February 2022
[subject] => Medical; Diabetes
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[post_date] => 2022-08-07 13:40:17
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[post_title] => Promoted Repair of DNA Double-Strand Break by MRNIP
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[researchers_name] => HUNG, Mien-Chie (洪明奇)
[researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan
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[research_footprints] => RAD50; MRE11; NBS1; phase separation; colorectal cancer; intrinsically disordered region; nonhomologous end joining; double-strand breaks; ataxia telangiectasia mutated; MRN complex; adenosine triphosphate; homologous recombination' fluorescence recovery after photobleaching; Escherichia coli
[graphic_abstract] =>
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[the_novelty] => Via in vitro and in vivo studies, this study discloses the underlying mechanism of DNA double-strand break (DSB) repair carried out by MRE11/RAD50/NBS1 (MRN) complex interacting protein (MRNIP). In intrinsically disordered region, the MRNIP forms condensates which then concentrates MRN complex into liquid-like droplets. When DSBs are formed and sensed, the MRNIP condensates proceed swiftly to the damaged DNA and promote the binding of damaged DNA to the concentrated MRN complex. This results in the autophosphorylation of ataxia telangiectasia mutated (ATM) followed by an accelerated DNA damage response and DSB end resection, promoting the homologous recombination (HR)-mediated DSB repair. Meanwhile, compared to normal rectum tissues, lower MRNIP expression is observed in radiation proctitis tissues. This implies that targeting MRNIP condensates could help to sensitize tumor cells to radiotherapy and lead to the development of radiation proctitis. In order to complement the existing findings, the authors are looking forward to the direct uncovering of the pathway underlying the impact of MRNIP condensates on MRN-mediated DSB sensing.
[the_background] => The repair of DNA double-strand breaks (DSBs) is no doubt a critical process to maintain the sustainability of organisms. Defective DSBs repair is very likely to cause devastating consequences such as cancer, embryonic death, and neurological disorders. In DSBs repair, the MRE11/RAD50/NBS1 (MRN) complex acts as a sensor towards DSBs and also an initiator of DNA damage responses. However, when DSBs is formed, it is still elusive with regards to how the MRN complex senses and binds to DNA rapidly. In the mean time, liquid-liquid phase separation (LLPS) is a process whereby molecules condense into a dense phase (high concentrated liquid droplets) whilst the remaining solution forms a dilute phase. Various studies associated LLPS to the repair of DNA damage and this indicated that LLPS might play a crucial role in DSBs repair. Therefore, an international collaboration with Sun Yat-sen University Cancer Center (China) and Sun Yat-sen University (China) took place to conduct an in-depth investigation on the role of MRNIP condensate in regulating HR-mediated DSB repair as well as the impact of LLPS on the function of MRNIP. The output of this study is an essential reference for future research which target to overcome diseases related to defective DSBs repairs.
[the_sdg_impact] => DNA DSBs, the most severe type of DNA damage, leads to apoptosis, gene mutation, and carcinogenesis if left unattended. As an effort to overcome defective DNA DSBs repair, a strong fundamental understanding about the relevant underlying mechanisms must be acquired. The pathway unveiled in this study provides significant insights on the pathway of DSBs repair and, thus, this study is very well-aligned with UNSDG 3: Good Health & Well-Being.
[article_url] => https://www.nature.com/articles/s41467-022-30303-w
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/MRNIP.jpg
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[publication_title] => MRNIP condensates promote DNA double-strand break sensing and end resection
[journal_title] => Nature Communications
[publisher] => Springer Nature
[year] => May 2022
[subject] => Medical; Biomedical Sciences; DNA
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[post_date] => 2022-08-07 13:28:10
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[post_title] => Overcoming Neurodegenerative Diseases Through Autophagy Initiation by Pridopidine
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[researchers_name] => WANG, Shao-Ming (王紹銘)
[researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan
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[research_footprints] => autophagy; guide RNA; E. coli; sigma receptor; Huntington disease; POM121; citrate synthase; Alzheimer disease; nuclear pore; c9orf72; nuclear pore complex; SIGMAR1; mouse model; sclerosis
[graphic_abstract] =>
[figures] =>
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[the_novelty] => This study reveals the signaling pathway underlying how pridopidine acts as an agonist in promoting autophagy for neuron protection. When a motor neuron is under pathological threats, pridopidine dissociates chaperone protein SIGMAR1 from HSPA5, allowing SIGMAR1 to proceed to the nuclear pore to chaperone nucleoporin POM121. Then, POM121 recruits KPNB1 so as to create an effective in-bound transportation of TFEB (from cytosol into nucleus), which is crucial for the initiation of autophagy. For the first time, the impact of SIGMAR1 agonists and antagonists on the chaperone activity of SIGMAR1 is elucidated, proving that the SIGMAR1 is a ligand-regulated chaperone. Results indicate that, with the presence of chaperone, the structural nucleoporin POM121 also serves as a signaling molecule which enables TFEB-mediated autophagy. Notably, pridopidine is able to effectively protect motor neuron NSC34 against H2O2-induced toxicity expressing the pathogenic (G4C2)288 repeat. In the absence of pridopidine in transfected NSC34 motor neuron, hexanucleotide (G4C2)RNA expansion (HRE) disrupts TFEB transport by hindering the interaction between SIGMAR1 and POM121. By complementing these discoveries with the ongoing clinical development of pridopidine, future studies may focus on designing a higher-efficacy therapy to treat neurodegenerative diseases.
[the_background] => Neurodegenerative diseases, such as Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), are closely related to impairments in autophagy. In ALS-frontotemporal lobar degeneration (ALS-FTD), autophagy is disrupted due to the defective transportation of transcription factor TFEB from the cytosol into the nucleus. Hexanucleotide (G4C2)RNA expansion (HRE) is accountable for the impairment but the exact molecular pathway involved has not been reported yet. Meanwhile, although the chaperone protein SIGMAR1 plays a pivotal role in autophagy, the underlying mechanism was ambiguous. Thus, this research aims to answer these uncertainties and also to examine the mechanism underlying the neuroprotective effect of pridopidine. The study outcome indicates that, by targeting the SIGMAR1, a pharmacological approach could potentially be designed to overcome diseases related to autophagy impairment.
[the_sdg_impact] => Millions of people suffer from neurodegenerative diseases globally. In United States, approximately 6 million and 1 million people are reported to be the victims of Alzheimer’s disease and Parkinson’s disease, respectively. These alarming figures can possibly be reduced by therapies which target the chaperone protein SIGMAR1. By explaining how pridopidine activates SIGMAR1, this research paves a clear direction which facilitates the development of therapies to treat neurodegenerative diseases (UNSDG 3: Good Health & Well-Being).
[article_url] => https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2063003
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[publication_title] => Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine
[journal_title] => Autophagy
[publisher] => Taylor & Francis Online
[year] => May 2022
[subject] => Medical; Neurodegenerative Diseases
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[post_date] => 2022-08-07 13:10:50
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[post_title] => Reprogrammed Tc17 Cells: Signalling Pathway & Cancer Treatment
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[researchers_name] => YEN, Hung-Rong (顏宏融)
[researchers_position] => School of Chinese Medicine, China Medical University, Taiwan
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[research_footprints] => adoptive cell therapy; IL-4; Fas ligand; IL-12; CD8 T-cell; IL-17; CD8 + T cell; cytotoxic T lymphocytes; NY-ESO-1; IL-23; colorectal cancer
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study reports a novel signalling pathway which converts IL-17-producing CD8+ T cells (Tc17) to IFN-γ producers, leading to enhanced antitumour activity and cytotoxicity of Tc17 cells. The pathway is initiated by IL-4 followed by PI3K/AKT signalling which induces the expression of Eomes and upregulates T-cell receptor-associated transmembrane adaptor 1 (TRAT1) in Tc17 cells. The upregulation of TRAT1 then promotes IL-4-induced T-cell receptor (TCR) stabilization and Tc17 cytotoxicity. IL-4, besides acting as an inducer, is capable of promoting Tc17 cells expansion to achieve higher antitumour potential. On top of these findings, a novel ex vivo procedure is proposed to reprogramme Tc17 extracted from human peripheral blood mononuclear cells (PBMC) in order to be applied in adoptive cell therapy (ACT) for cancer patients. By having enhanced cytotoxicity, the novel ACT could potentially treat a wide spectrum of cancers.
[the_background] => Immune effector cell (IEC) therapy primarily involves the use of one’s immune system to treat cancer in his/her own body. Despite its proven potential, there is a huge room for development as the recently applied IEC strategies induce acute but short responses. IL-17-producing CD8+ T cells (Tc17) has been identified as a promising candidate for IEC therapy for its ability to be reprogrammed as cytotoxic anti-tumour effectors. However, Tc17-based IEC is yet to be ready due to the limited knowledge on the factors affecting Tc17 reprogramming and the mechanisms underlying its cytotoxicity promotion. Thus, upon discovering the answers to these uncertainties, this study has taken extra miles to establish a feasible procedure to expand Tc17 from peripheral blood of cancer patients. The research outcome creates a profound impact in oncology by enhancing the applicability and efficacy of Tc17-based IEC therapy.
[the_sdg_impact] => With more than 100 types of cancer reported, the continuous development of immunotherapy is crucial to uphold the survival rate of cancer patients. The discovery of a potent Tc17-based adoptive cell therapy (ACT) serves not only as a possible cure, but also as robust knowledge base for future research. By disclosing the signalling pathway involved, this study facilitates the development of new cancer therapies (UNSDG 3: Good Health & Well-Being).
[article_url] => https://onlinelibrary.wiley.com/doi/10.1111/imm.13473
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[publication_title] => Adoptive transfer of IL-4 reprogrammed Tc17 cells elicits anti-tumour immunity through functional plasticity
[journal_title] => Immunology
[publisher] => Wiley Publishing
[year] => March 2022
[subject] => Medical; Cancer
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[post_date] => 2022-08-07 12:31:53
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[post_title] => PKCδ/SGLT1 Co-targeting for Improved Therapeutic Efficacy of EGFR TKIs in NSCLC Patients
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[researchers_name] => HUANG, Wei-Chien (黃偉謙)
[researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/EGFR.png
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[research_footprints] => epidermal growth factor receptor; triple-negative breast cancer; glucose uptake; positron emission tomography; PKCδ; epithelial-mesenchymal transition; tyrosine kinase inhibitor; non-small cell lung cancer; glucose; transporter; progression-free survival
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study provides strong evidence that glucose metabolic re-wiring may contribute to the development of acquired resistance of non-small cell lung cancer (NSCLC) to epidermal growth factor receptors tyrosine kinase inhibitor (EGFR TKIs). The findings suggest that NSCLC cells with acquired EGFR TKI resistance are more tolerant to low glucose-induced autophagy following a metabolic shift to higher glucose uptake and glycolysis activity due to upregulation of active sodium/glucose co-transporter 1 (SGLT1) by Thr678-phosphorylated EGFR, in a protein kinase C delta (PKCδ)- dependent manner. Therefore, the combination of SGLT1 inhibitor with EGFR TKIs shows a synergetic effect in reducing tumor growth and glucose uptake in vitro and in vivo. Future studies can be conducted to determine if hormone receptors are involved in the regulation of SGLT1 expression in lung cancer tissues.
[the_background] => EGFR, a membrane-bound tyrosine kinase receptor, has been found to be a critical oncogene in promoting tumorigenesis, mitogenesis, and tumor progression of various cancer types, including NSCLC. Small molecule tyrosine kinase inhibitors (TKIs) targeting the ATP-binding pocket of the EGFR kinase domain were developed and approved for NSCLCs. However, the secondary EGFR mutations and activations of alternative receptor tyrosine kinases (RTKs) created a bypass track, leading to the failed responses to EGFR TKIs, yet fail to fully account for the development of acquired resistance to these drugs in NSCLC patients. Mounting evidence has proved that EGFR impacts the rewiring of the glucose metabolic network to promote tumor progression in NSCLC. Therefore, this study aims to understand the glucose metabolic re-wiring pathway in NSCLC patients with acquired EGFR TKI resistance. The findings would potentially be used to explore an effective treatment strategy against EGFR TKI resistance.
[the_sdg_impact] => Approximately 85% of lung cancers are recognized as NSCLC. Mutations lead to EGFR amplification and overexpression and have been associated with NSCLC progression. Inhibitors targeting EGFR tyrosine kinase activity were used to block the downstream signaling pathway and showed promising therapeutic efficacy. Unfortunately, most patients with NSCLC who are treated with these drugs develop resistance. Much evidence has proved that EGFR promotes tumor progression by rewiring glucose metabolic networks in NSCLC. By identifying the biological mechanisms that associate glucose metabolic re-writing pathway with NSCLC treatment resistance, this study expands the possibility of increasing the effectiveness of the existing treatment. Ultimately, the proposed combination of SGLT1 inhibitor with EGFR TKIs would serve as a new therapeutic strategy to reduce the mortality rate of patients with NSCLC (UNSDG 3: Good Health & Well-Being).
[article_url] => https://www.nature.com/articles/s41388-021-01889-0#Bib1
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/08/EGFR-2.jpg
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[publication_title] => PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs
[journal_title] => Oncogene
[publisher] => Springer Nature
[year] => June 2021
[subject] => Medical; Biomedical Sciences; Lung Cancer
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[post_date] => 2022-08-07 12:16:10
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[post_title] => Developing High Efficacy Immunotherapy via Casein Kinase 2 Inhibition
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[research_footprints] => programmed cell death 1; E. coli; tumor microenvironment; immune cell; alanine transaminase; protein kinase; t cell; Triple-negative breast cancer; The Cancer Genome Atlas; T-cell receptor; blood urea nitrogen; casein kinase 2; granzyme A; dendritic cell; CD8 alpha; cullin 3; aspartate transaminase; Immune checkpoint blockade
[graphic_abstract] =>
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[the_novelty] => This study unveils an immunotherapeutic approach to treat cancer by avoiding the phosphorylation of programmed cell death ligand 1 (PD-L1) through casein kinase 2 (CK2) inhibition. The inhibition of CK2 leads to degradation of PD-L1 in cancer and dendritic cells (DCs) followed by the activation of T cells by DCs which, in turn, enhances the antitumor activity. In other words, CK2 hinders the antigen-specific T-cell function through phosphorylation of PD-L1. Meanwhile, in preclinical trial, mouse mammary tumor exhibits suppressed growth when treated by a CK2 inhibitor combined with an antibody against T-cell immunoglobulin mucin-3 (Tim-3). Collectively, the outcome indicates that the approach is not only effective on triple-negative-breast-cancer (TNBC), but also applicable for other cancer types, such as lung cancer, prostate cancer, and melanoma. In order to validate this approach, future clinical studies can be conducted to focus on its anti-tumor efficacy in different types of cancer tissues.
[the_background] => Casein kinase 2 (CK2) has been proven to be a potential target in treating cancers. Although CK2 is crucial for cell sustainability, its upregulation in all cancers has shown consistent trend in promoting tumor cell growth, leading to poor prognosis. During the inhibition of CK2, significant improvement was observed in the antitumor activity of immune checkpoint receptor blockade using anti–CTLA-4 antibody. This suggests that CK2 inhibition could potentially overcome the ineffectiveness of anti–PD-1/PD-L1 immune checkpoint blockade (ICB) treatment experienced by a substantial amount of cancer patients. Hence, in an international collaboration with the Department of Molecular and Cellular Oncology from The University of Texas MD Anderson Cancer Center (USA), this study aims to investigate the mechanism of PD-L-1 regulation by CK2 and have successfully demonstrated CK2–PD-L1 pathway blockage as a high potential tumor treatment. Since this approach is applicable for various cancer types, it is likely to increase the chances for human to survive cancers.
[the_sdg_impact] => Cancer-related researches have been progressing dramatically but many of the potential therapies are effective to only limited types of cancer and patients. Since CK2 inhibition is a high-potential treatment for multiple cancer types, it can be coupled with other effective therapies to achieve better outcome. The output of this study creates a significant milestone in cancers treatment, realizing UNSDG 3: Good Health & Well-Being.
[article_url] => https://aacrjournals.org/cancerres/article-abstract/82/11/2185/699105/Phosphorylation-and-Stabilization-of-PD-L1-by-CK2?redirectedFrom=fulltext
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[doi] => https://doi.org/10.1158/0008-5472.can-21-2300
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[publication_title] => Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function
[journal_title] => Cancer Research
[publisher] => American Association of Cancer Research
[year] => June 2022
[subject] => Medical; Biomedical Sciences; Cancer; Immunotherapy
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[post_date] => 2022-08-07 11:41:37
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[post_title] => Inhibition of Glucocorticoid Receptor for Enhanced Anti-Tumor Immunity Against Pancreatic Cancer
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[research_footprints] => T cell; immunotherapy; tumor cell; fetal bovine serum; immune checkpoint; tumor microenvironment; pancreatic cancer; immune evasion; Cushing syndrome; pancreatic ductal adenocarcinoma; cancer cell; The Cancer; Genome Atlas; clinical trial; granzyme B; progesterone receptor; horseradish peroxidase; phorbol myristate acetate; phosphate-buffered saline; magnetic resonance imaging; cytotoxic T lymphocytes; Chromatin; immunoprecipitation; major histocompatibility complex class I; glucocorticoid response elements; Immune checkpoint blockade; glucocorticoid receptor
[graphic_abstract] =>
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[the_novelty] => In an international collaboration with the Department of Experimental Radiation Oncology from The University of Texas MD Anderson Cancer Center (USA), this study discovers that glucocorticoid receptor (GR) is a promising target for overcoming pancreatic cancer. Based on animal trials, GR inhibition results in downregulation of programmed death-ligand 1 (PD-L1) and upregulation of major histocompatibility complex class I (MHC-I) in tumor cells. These effects then improve both anti-tumor immunity and response to immune checkpoint blockade (ICB) therapy. Consistent outcomes are also observed in patients with pancreatic ductal adenocarcinoma (PDAC). Meanwhile, clinical GR antagonist mifepristone is able to produce similar results although its anti-tumor effect is not as profound as that of GR inhibition. Nonetheless, the efficacy of the combined therapy of GR inhibition and mifepristone is worth to be tested clinically. In order to move towards materialization, future studies should focus on several scopes including: to determine whether targeting GR sensitizes pancreatic cancer to chemotherapies through immune regulation, to investigate the outcome of applying the same therapy on other types of cancer, and to optimize the dosage of GR antagonist mifepristone so as to enhance its efficacy with minimum toxicity.
[the_background] => To date, an effective treatment for pancreatic cancer has yet to be developed. Although chemotherapy and radiotherapy are the common therapies being used to treat patients of pancreatic cancer, they are very likely to cause severe deterioration in patients. Furthermore, major driver genes for pancreatic cancer (e.g. KRAS, TP53, CDKN2A, and SMAD4) have not been approved by FDA to be applied as clinical therapies yet. Despite showing positive effects on other cancer types, immune checkpoint blockade (ICB) therapies were not effective for pancreatic cancer, regardless of whether being applied alone or combined with other therapies (i.e. chemotherapy, radiotherapy, targeted therapy, and vaccination). Glucocorticoid receptor (GR) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. Since the anti-tumor potential of GR has been demonstrated in past research, this study examines how GR can be part of the strategy to overcome pancreatic cancer. The output of this study show that GR inhibition is effective in treating pancreatic cancer and a feasible therapy can be derived based on that.
[the_sdg_impact] => Pancreatic cancer is projected to become the second leading cause of cancer-related death by 2030. Pancreatic ductal adenocarcinoma (PDAC) patients in the United States show a 5-year survival rate of as low as 6%. These alarming figures imply the urgent need for more effective therapies. As there is a huge room of improvement for the existing therapies of pancreatic cancer, the findings of this study are essential for the development of relevant therapies. By identifying GR as a target, this research contributes to the realization of breakthrough strategies to treat PDAC patients (UNSDG 3: Good Health & Well-being).
[article_url] => https://www.nature.com/articles/s41467-021-27349-7
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[doi] => https://doi.org/10.1038/s41467-021-27349-7
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[publication_title] => Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
[journal_title] => Nature Communications
[publisher] => Springer Nature
[year] => December 2021
[subject] => Medical; Biomedical Sciences; Pancreatic Cancer
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[post_title] => Stronger Anti-Tumour Immunity in Colorectal Cancers via Inhibition of Protein Phosphatase 2A
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[researchers_name] => HUNG, Shih-Chieh (洪士杰)
[researchers_position] => Integrative Stem Cell Center, Department of Orthopedics, China Medical University Hospital, Taiwan
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[research_footprints] => Gene Expression Omnibus; loss of heterozygosity; microsatellite instability; cytotoxic T cell; retinoblastoma protein; dendritic cells; Tissue microarray; Methylation-specific PCR; histone deacetylase; next-generation; sequencing; MLH1; phosphate-buffered saline; immune checkpoint blockade; protein phosphatase; mismatch repair deficiency; gene set enrichment analysis; polyvinylidene fluoride; T cell receptor; colorectal cancer
[graphic_abstract] =>
[figures] =>
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[the_novelty] => To better understand microsatellite-instable (MSI) tumours as a key to overcoming colorectal cancers (CRCs), this study shows that the inhibition of protein phosphatase 2A (PP2A) could lead to the loss of DNA mismatch repair (MMR) genes (i.e. causing MMRd), resulting in the conversion of microsatellite-stable (MSS) into MSI tumours. The PP2A inhibition brings about the conversion via two different pathways, i.e. by increasing retinoblastoma protein phosphorylation and by increasing histone deacetylase (HDAC)2 phosphorylation. Moreover, the inactivation of PP2A also enhances MSI tumours’ response to immune checkpoint blockade (ICB). In short, PP2A inhibition initiates neoantigen production, increases cytotoxic T cell infiltration and improves response to ICB. These results were obtained from animal models as well as human cancer cell lines and tissue array. In order to materialise an effective therapy based on the findings, future studies should investigate the effect of mRNA dysregulation or mutations of the genes on the adaptive and acquired resistance to ICB.
[the_background] => 15% of sporadic colorectal cancers (CRCs) are closely associated to microsatellite-instable (MSI) tumours with defective DNA mismatch repair (MMR). Compared to microsatellite-stable (MSS) tumours, focusing on the mechanism of MSI tumours development is a more practical strategy as MSI tumours exhibit better prognosis and response to immune checkpoint blockade (ICB) (i.e. a type of immunotherapy drug). Studies show that both CRC and non-CRC patients with MMR deficiency (MMRd) have better responses to programmed death 1 (PD-1) ICB therapy. These findings support the need to focus on MSI tumours even though the molecular mechanisms have yet to be confirmed. Meanwhile, although protein phosphatase 2A (PP2A)-targeted anti-tumour therapies have received significant attention, the anti-tumour effects of activating or inhibiting PP2A activity is uncertain. Furthermore, the number of studies on PP2A’s tumour-intrinsic signaling and response to ICB are still scanty. Therefore, this research aims to achieve two goals, i.e. to investigate the mechanism of MMRd and to examine the effect of PP2A inhibition on the conversion of MSS to MSI tumours. Other than solving the previously unanswered questions, the output of this study provides valuable insights to the possible feasible ways to overcome cancers by focusing on PP2A.
[the_sdg_impact] => In 2020, CRC was the second most common cause of cancer death worldwide, causing almost 1 million deaths. It was the third most common cancer in men but the second most common cancer in women, after breast cancer. The in-depth discussion on the potential of PP2A inhibition in fighting CRC opens up an avenue for the realisation of new treatments for CRC. With better knowledge base and more effective therapy, tremendous amount of CRC patients with will stand higher chance to survive (UNSDG 3: Good Health & Well-being).
[article_url] => https://www.nature.com/articles/s41467-021-27620-x
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[publication_title] => Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response
[journal_title] => Nature Communications
[publisher] => Springer Nature
[year] => December 2021
[subject] => Medical; Orthopedics; Colorectal Cancer
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[post_date] => 2022-08-07 11:02:28
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[post_title] => Dual-Action Liver Cancer Therapy via Co-Inhibition of PARG & PD-1
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[researchers_name] => HUNG, Mien-Chie (洪明奇)
[researchers_position] => Graduate Institute of Biomedical Sciences; Center for Molecular Medicine; Research Center for Cancer Biology; Drug Development Center, D2 China Medical University, Taiwan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/08/PARG.png
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[research_footprints] => c-Myc; immunotherapy; PD-1; cell cycle checkpoint; The Cancer Genome Atlas; mismatch repair; Hepatocellular carcinoma; quantitative RT-PCR; DDB1; dna replication; PARG
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/08/1-s2.0-S0168827822000721-ga1.jpg
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[the_novelty] => As part of the effort to develop an effective therapy for liver cancer hepatocellular carcinoma (HCC), this study revealed the role of poly (ADP-ribose) glycohydrolase (PARG) enzyme in the development of HCC. PARG acted as a main culprit for the spread of HCC through the newly discovered PARG/DDB1/c-Myc signaling pathway which implies PARG as a potential biomarker for HCC treatment. More importantly, when PARG was inhibited, improved condition was observed in mice undergoing anti-PD-1 anticancer drug therapy. The results indicate that the inhibition of both PARG and PD-1 is a highly-effective dual-action therapy for HCC. With the promising output, future clinical trials can be conducted to determine and to optimize the efficacy of the dual-action therapy.
[the_background] => Despite being actively involved in various cellular activities (e.g. DNA replication, transcription, and apoptosis), PARG was also reported to cause tumor growth. Furthermore, positive outcomes were observed when PARG-targeted strategy was implemented in cancer therapies. All this led to unanswered questions related to the exact regulatory mechanism of PARG especially in the growth of cancer tissues. Hence, an international collaboration with the Department of Liver Surgery and Transplantation of Fudan University (Shanghai) took place to examine the physiological roles and signaling pathway of PARG in HCC progression. Co-inhibition of PARG and PD-1 was reported for the first time as an effective dual-action strategy for patients with HCC. These findings showed that other combination strategies involving PARG inhibition could possibly lead to effective treatment for other types of cancer.
[the_sdg_impact] => Within the wide spectrum of cancer, hepatocellular carcinoma (HCC) alone has caused more than 600,000 deaths each year globally. Since both chemotherapy and radiotherapy often cause relapse in patients, immunotherapy via PARG-inhibition could potentially minimize the side-effects while increasing the chance for recovery. Thus, this study contributes to the fulfilment of UNSDG 3: Good Health & Well-being by sharing profound discoveries in the research and development of cancer therapies.
[article_url] => https://www.sciencedirect.com/science/article/pii/S0168827822000721
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[doi] => https://doi.org/10.1016/j.jhep.2022.01.026
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[publication_title] => PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy
[journal_title] => Journal of Hepatology
[publisher] => Elsevier
[year] => July 2022
[subject] => Medical; Biomedical Sciences; Liver Cancer
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[post_date] => 2022-07-14 16:14:45
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[post_title] => Tourists Retention by Place Attachment, Emotional Experience & Religious Affiliation
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[research_footprints] => Place attachment; Place identity; Place dependence; Emotional experience; Religious destination loyalty; Religious affiliation
[graphic_abstract] =>
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[the_novelty] => In the context of religious tourism destinations, this study elucidated that the effect of visitors’ place attachment on destination loyalty is given rise by their on-site emotional experience (a mediator). Meanwhile, the extent of visitors’ religious affiliation (a moderator) determined how much place attachment and emotional experience would affect destination loyalty. Place dependence (a dimension of place attachment) showed an indirect effect on destination loyalty via emotional experience. In comparison to Hindu and Muslim visitors, this effect (moderated by religious affiliation) was strongest among Christian visitors. The data used in this study was obtained from a survey that involved 812 Attur Feast attendees, followed by a series of multiple regression analyses. Future studies may test the consistency of this experimental model by replicating it in contexts involving different religions. In addition, more dimensions of place attachment (e.g., place effect and place social bonding), extra psychological concepts (e.g., emotions and perceived authenticity), and reputation of religious destination can be included as part of the research.
[the_background] => Religious festivals are valuable occasions as they embrace customs and beliefs. Most of the festivals are being held at unique locations, fostering a sense of place attachment in the attendees. In turn, place attachment was shown to result in the development of emotional experience. However, an inadequate amount of studies have looked into the effect of place attachment on emotional experience and how this relationship leads to destination loyalty. Besides that, the effect of religious affiliation on those relationships has not been assessed yet. In order to complement the research gap, this study evaluated the role of visitors' place attachment and emotional experience on destination loyalty, with religious affiliation as a moderator within the model. The contribution of the outcome includes facilitating the planning for sustainability of religious events and providing constructive strategies to promote religious festivals and events.
[the_sdg_impact] => In 2019, India’s Travel & Tourism GDP contribution grew by 4.9%, the third highest after China and the Philippines. In the following year, it created 31.8 million jobs which contributed to 7.3% of the total employment in the country (source: ibef.org). These data indicate that tourism plays a major role in the livelihood of the people in India. Hence, the government should prioritize the industry by implementing policies to support and enhance tourism. This research sheds light on the influence of emotional experiences and religious affiliation on destination loyalty. Thus, its goal is perfectly aligned with UNSDG8: Decent Work & Economic Growth.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S2211973620301045?via%3Dihub
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[doi] => https://doi.org/10.1016/j.tmp.2020.100737
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[publication_title] => Visitors' loyalty to religious tourism destinations: Considering place attachment, emotional experience and religious affiliation
[journal_title] => Tourism Management Perspectives
[publisher] => Elsevier
[year] => October 2020
[subject] => Hospitality and Tourism; Tourists Retention
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[post_date] => 2022-07-14 16:07:07
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[post_title] => Factors Influencing Tourists’ Destination Loyalty
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[research_footprints] => place attachment; destination loyalty; emotional solidarity; perceived safety; religious festival; moderated mediation
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => What keeps a visitor returning to a festival or tourist destination? In the context of a religious festival, this study demonstrated that visitors’ place attachment is a determinant for destination loyalty and emotional solidarity. Moreover, destination loyalty is positively affected by emotional solidarity. Place attachment also positively affected destination loyalty through emotional solidarity (a mediator). The strength of such effect relied on the visitor level of perceived safety (a moderator) at the festivals. The data collection and sampling involved 813 visitors during the Attur Church Fest in Karkala, India. Structural Equation Modelling (SEM) was used to test the hypotheses. The mediation and moderated mediation effects between the study constructs were tested using Process Macro 4.0. In order to go more in-depth, future studies can include obligatory religious motivations, shared behavior, and shared beliefs as antecedents of destination loyalty and emotional solidarity in a religious context. Furthermore, the influence of visitors’ perceived level of safety in the effect of antecedents on destination loyalty should also be emphasized. Destination managers should promote these festivals as an encounter momentum between host and guest and a sharing space of religious experiences that amplify the authenticity of the place. Publicising these aspects will definitely enhance the footfall (national and international) which in turn is beneficial to increase tourism potential of the region.
[the_background] => During religious festivals, place attachment is closely related to emotional solidarity (the degree of closeness between residents and tourists in a destination). Meanwhile, on-spot safety is a critical reason tourists return to the festivals. Although emotional solidarity contributes to a sense of safety, it remains obscure whether perceived safety may moderate the effect between place attachment and destination loyalty via emotional solidarity. Besides that, the effect of place attachment and emotional solidarity on destination loyalty is not investigated. To address the literature gap, this study disclosed how place attachment and emotional solidarity could influence destination loyalty and how perceived safety may moderate these relationships. The outcomes of this research serve as important guidelines for local authorities and festival organizers to implement necessary improvements to retain the loyalty of tourists and attendees.
[the_sdg_impact] => In 2020, the GDP contribution of the Indian travel & tourism industry was US$ 121.9 billion. Also, it accounted for 31.8 million jobs, which was 7.3% of the total employment in the country (source: ibef.org). These significant figures indicate that the Indian government should pay attention to enhancing and innovating the industry. By highlighting important theories that can promote development-oriented policies in supporting sustainable tourism, this study materialized UNSDG 8: Decent Work & Economic Growth. In the 2030 Agenda for Sustainable Development SDG target 8.9, aims to “by 2030, devise and implement policies to promote sustainable tourism that creates jobs and promotes local culture and products”. The importance of sustainable tourism is also highlighted in SDG target 12.b. which aims to “develop and implement tools to monitor sustainable development impacts for sustainable tourism that creates jobs and promotes local culture and products”.
[article_url] => https://journals.sagepub.com/doi/full/10.1177/0047287518824157
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[publication_title] => Visitors’ Place Attachment and Destination Loyalty: Examining the Roles of Emotional Solidarity and Perceived Safety
[journal_title] => Journal of Travel Research
[publisher] => Sage Publishing
[year] => February 2019
[subject] => Hospitality and Tourism; Tourists Retention
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[post_date] => 2022-07-14 15:54:38
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[post_title] => Facilitating New Product Development in Restaurant Through Social Capital & Knowledge Sharing
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[research_footprints] => New product development; Knowledge sharing intention; External social capital; Internal social capital
[graphic_abstract] =>
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[the_novelty] => In the context of the high-end restaurant business in India, this study demonstrated that the quality of relationships within the business team (internal social capital, ISC) positively affects the quality of relationships formed with outsiders (external social capital, ESC). This phenomenon was mainly due to the collectivist culture in India, whereby good relationships (cultivated internally and externally) give rise to social support and identity. Despite that, only ISC has a positive impact on the knowledge sharing index (KSI) which, in turn, acted as a driving force for new product development (NPD). The results were obtained by deploying partial least square structural equation modeling to analyze the input data collected from 523 participants from the managerial team of high-end restaurants in India. For future studies, the authors proposed to investigate other determinants of sharing behaviors (e.g., resilience-building capacities, employee engagement, psychological ownership), different types of capital (e.g., financial and human), and other outcomes of knowledge sharing (e.g., customer orientation, creativity performance, and job performance).
[the_background] => Innovation and new product development (NPD) are key elements in defining successful hospitality organizations, such as hotels, tour agencies, restaurants, and food and beverage providers. Meanwhile, both internal and external social capital (SC) were seen as reliable predictors of knowledge-sharing behaviors. Despite the confirmed influence of knowledge-sharing behaviors in facilitating service innovation in tourism firms and restaurants, researchers have yet to determine if SC is a determinant of knowledge-sharing intention (KSI) and new product development (NPD). In order to fill up the research gap, this study investigated the impact of both internal and external SC concurrently on restaurant innovation through KSI and NPD. The results acted as a valuable reference for the government to design policies for growing and supporting the restaurant sector.
[the_sdg_impact] => The hospitality industry has taken a brutal hit since the COVID-19 pandemic started, and countless restaurants and hotels were forced to close down. In the current recovering stage of this industry, innovative plans are crucial to catch up with the new norm that altered the demand and preferences of consumers. By examining the factors affecting innovation, this research strived to facilitate new product development in restaurants. Thus, it realized UNSDG 8: Decent Work & Economic Growth.
[article_url] => https://www.emerald.com/insight/content/doi/10.1108/IJCHM-04-2020-0345/full/html
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[publication_title] => The impact of social capital and knowledge sharing intention on restaurants’ new product development
[journal_title] => International Journal of Contemporary Hospitality Management
[publisher] => Emerald Publishing
[year] => September 2020
[subject] => Hospitality and Tourism; Restaurants
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[post_date] => 2022-07-14 15:40:29
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[post_title] => Assessment of Urban Sprawl in Eight Mid-Sized Indian Cities
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[researchers_name] => CHETTRY, Vishal
[researchers_position] => Manipal School of Architetcure and Planning, Manipal Institute of Technology, India
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Urban.png
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[research_footprints] => Urban sprawl index; RS & GIS; Landscape metrics; Mid-sized city; India
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => By applying modern research tools like remote sensing (RS) and geographic information system (GIS), this study showed that eight mid-sized Indian cities underwent a rapid outward expansion of built-up areas, with irregular shapes of built-up patches. Furthermore, secondary urban core and urban fringe showed an increasing trend. Despite the uptrends, there was a decline in population density in most cities. Urban sprawl index (USI) was formulated by combining eleven significant variables related to urban sprawl patterns and typologies from open source datasets. Such index can be used in developing and under developed countries where data availability is a major constraint. The urban sprawl index (USI) varied from 20.73 to 11.28 in Thiruvananthapuram Urban Agglomeration (UA) and Dehradun UA.
[the_background] => Urban sprawl refers to the expansion of poorly planned, low-density, auto-dependent development, creating high segregation between residential and commercial uses. It causes adverse effects on the environment and biodiversity in India. Although urban growth is likely to take place mainly in mid-sized cities, thorough research emphasizing urban sprawl assessment of mid-sized cities remains scarce. Hence, this study adopted several modern research tools to analyze the spatio-temporal urban sprawl in eight mid-sized Indian cities from regions with different physiography. Besides enriching the database of the urban sprawl index (USI) for future research, the output of this research served as a reliable reference for the local authorities to plan for sustainable urban development.
[the_sdg_impact] => Proper urbanization is crucial for the healthy development of the economy, society, and environment of any country. On the other hand, urban sprawl is known to bring the residents and the environment negative consequences, such as water and air pollution, increased traffic fatalities and jams, and loss of agricultural capacity. As the findings of the study serve as a reference to strengthen national and regional development planning, it indirectly contributes to the realization of UN SDG 11: Sustainable Cities & Communities.
[article_url] => https://link.springer.com/article/10.1007/s12524-021-01420-8
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[doi] => https://doi.org/10.1007/s12524-021-01420-8
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[publication_title] => Urban Sprawl Assessment in Eight Mid-sized Indian Cities Using RS and GIS
[journal_title] => Journal of the Indian Society of Remote Sensing
[publisher] => Springer Nature
[year] => August 2021
[subject] => Architetcure; Geographic Information System
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[post_date] => 2022-07-14 15:31:22
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[post_title] => Wastewater Management Using Aqueous Two-Phase System (ATPS)
[post_excerpt] =>
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[researchers_name] => VARADAVENKATESAN, Thivaharan
[researchers_position] => Department of Biotechnology, Manipal Institute of Technology, India
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Wastewater.png
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[research_footprints] => Aqueous two-phase system; WastewaterProteins; Biomolecules; Wastewater treatment; Phenolic compounds
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study provides an overview of the different applications of the aqueous two-phase system (ATPS) in recovering valuables and contaminants from industrial and domestic waste discharges. As a whole, ATPS is simple, efficient, rapid, flexible, economical, and biocompatible. Moreover, its selectivity, purity, and yield are up to the standards and sometimes even better than conventional waste discharge treatment technology, making it an ideal extraction and purification technology. Additionally, literature also proved that the superior capabilities of ATPS are fruits of continuous research and development of the system, ultimately transforming it into a versatile mechanism suitable across various industries to purify waste discharges. In light of its elaborate benefits, the study suggests that the system be made compatible with the industrial scale to improve the integration and application process, adding value to the respective waste streams.
[the_background] => A well-designed product manufacturing system depends on the efficiency of production and valuable product reclamation, and its downstream waste management strategy. Alas, conventional extraction and purification technologies incur high operational costs, produce lower yield, lack specificity and up-scalability, and use non-eco-friendly components. Alternatively, the aqueous two-phase system (ATPS) has been identified as a better option to overcome the limitations of existing technologies and tools. Therefore, this study aims to review the application of ATPS in diverse industries, emphasizing its capabilities and suggesting ways to improve its industrial-scale implementation.
[the_sdg_impact] => According to GAIA, a global network working towards a just and waste-free world without incineration, approximately 2.01 billion tons of waste are generated annually. Unless effective measures are put to work, it is projected that by 2050, the total amount of waste generation will increase by 70% to 3.4 billion tons. Accordingly, Zero Waste initiatives have been adopted in various regions as a sustainable solution to address such waste crisis. Based on the outcome of this review, the aqueous two-phase system (ATPS) could potentially contribute to achieving the targets of the UN’s 12th Sustainable Development Goal, Responsible consumption and production. The adoption of said system across various industries would lead to environmentally sound management of chemicals and wastes throughout the production life cycle while complying with the agreed international framework of Zero Waste.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0048969721013619
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Wastewater-.jpg
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[doi] => https://doi.org/10.1016/j.scitotenv.2021.146293
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[publication_title] => Recovery of value-added products from wastewater using Aqueous Two-Phase Systems – A review
[journal_title] => Science of The Total Environment
[publisher] => Elsevier
[year] => July 2021
[subject] => Biotechnology; Wastewater
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[post_date] => 2022-07-14 15:19:56
[post_date_gmt] => 2022-07-14 07:19:56
[post_content] =>
[post_title] => Liquid Crystallinity Optimization through Polar Substituents and Chain Length
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[researchers_name] => BHAGAVATH, Poornima
[researchers_position] => Department of Chemistry, Manipal Institute of Technology, India
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[research_footprints] => Hydrogen bonding; Induced mesomorphism; Linear HB complexes; Pyridyl units; Smectic phases; Dihalobenzoic acids; Polar substituents
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study demonstrates that when dihalobenzoic acids and pyridyl units (both non-mesogenic) are mixed in an equimolar ratio, a hydrogen-bonded (HB) complex with liquid crystalline behavior (mesomorphism) will be formed. Compared to monohalobenzoic acid HB complexes (with the same pyridyl units), higher liquid crystallinity (mesomorphic thermal stabilities) is observed in dihalobenzoic acid HB complexes. When comparing the effect of different dihalobenzoic acids, 4-chloro-2-fluorobenzoic acid HB complexes exhibit higher liquid crystallinity than 2,4-dichlorobenzoic acid HB complexes. In addition, when a series of pyridyl units with increasing chain length are used, the HB complexes exhibit an increasing liquid crystalline thermal range initially but followed by a downtrend. These results are obtained by studying the samples using various characterization techniques, such as infrared spectroscopy, polarizing optical microscopy, and differential scanning calorimetry.
[the_background] => Studies related to liquid crystals (LC) formed through hydrogen bonds have been receiving attention due to their increasing demand in applications like electro-optical and laser devices. The thermal stability of liquid crystals (mesomorphs) relies on various factors, including dipole-dipole interactions, London dispersion forces, dipole-induced dipole interactions, polarity, and polarizability of different molecules. Meanwhile, terminal polar substituents on molecules could significantly change the polarity and polarizability of the system, giving rise to the enhancement or stabilization of mesomorphism. Due to the intriguing phenomena observed in hydrogen-bonded LC systems and the limited number of LC research focusing on mixtures of dihalobenzoic acid and pyridyl units exhibiting, this study aims to examine the effect of hydrogen bond interactions in non-mesomorphic binary systems (using dihalobenzoic acids) on liquid crystalline behavior. These results serve as a valuable complement to the existing knowledge base, specifically in the properties of liquid crystal synthesized using various dihalobenzoic acid and pyridyl units.
[the_sdg_impact] => Liquid crystals are a crucial material in applications such as smartphone cameras, device displays, hyperspectral imaging, semiconductors failure analysis, lasers, and pico-projectors. Therefore, an extensive study focusing on understanding and improving liquid crystal properties is necessary to catch up with the emerging applications. The outcomes of this research have successfully enhanced the research on liquid crystals, fulfilling the targets of UNSDG 9: Industry, Innovation & Infrastructure.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0167732221010370?via%3Dihub
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[doi] => https://doi.org/10.1016/j.molliq.2021.116313
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[publication_title] => Influence of polar substituents and flexible chain length on mesomorphism in non-mesogenic linear hydrogen bonded complexes
[journal_title] => Journal of Molecular Liquids
[publisher] => Elsevier
[year] => August 2021
[subject] => Chemistry; Molecular Liquids
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[post_date] => 2022-07-14 15:05:23
[post_date_gmt] => 2022-07-14 07:05:23
[post_content] =>
[post_title] => Improvement of the Antenna Isolation by the Bandstop Filter Decoupling Technique
[post_excerpt] =>
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[post_name] => improvement-of-the-antenna-isolation-by-the-bandstop-filter-decoupling-technique
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[researchers_name] => ALI, Tanweer
[researchers_position] => Department of Electronics and Communication Engineering, Manipal Institute of Technology, India
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/antenna.png
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[research_footprints] => Antennas; MIMO communication; PIN photodiodes; Switches; Mutual coupling; Electronic mail; Resonant frequency
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => In the study, the proposed miniature reconfigurable multiple-input multiple-output (MIMO) antenna was developed using a switchable bandstop filter as a decoupling structure that can be used for wireless communication systems. The MIMO antenna can enhance channel capacity and reliability as well as integrate multiple communication standards. The antenna was developed through four major steps: creating a single antenna, followed by developing two-port antennas. Then, the reconfigurable decoupling network was developed, which finally led to reconfigurable MIMO antenna development. When the antenna was tested at two different modes, respectively, various parameters were observed, and the measured results of the antenna verified the simulation results. The study results indicated that the antenna efficiency was 86.8% and 91.47% in Mode 1 and Mode 2, respectively. The study indicated that larger reconfigurable MIMO antennas could be developed in the future, potentially consisting of more than two antenna elements through the proposed isolation technique.
[the_background] => The MIMO antenna with the proposed bandstop filter reconfiguration can enhance channel capacity and reliability as well as integrate multiple communications standards. This signifies that the bandstop filter reconfiguration proposed in the study succeeds. The goal of the study is to prevent mutual coupling between two closely spaced monopole antenna elements and reconfigure the antenna characteristics. In the study, the MIMO antenna with the proposed bandstop filter reconfiguration showed higher isolation at both operating frequencies than the other antennas reported. The bandstop filter decoupling technique contributed to the improvement in the isolation of the antenna. The study evaluated other antennas and indicated that the antenna proposed in the study has a better dimension than other antennas making it easier to integrate into compact wireless devices.
[the_sdg_impact] => Wireless communication systems are increasingly adopted in our everyday life due to flexibility and mobility. Soon, the 5G or fifth generation of cellular networks, one of the fastest wireless technologies to date, would be available globally. The study is strongly associated with “Goal 9: Industry, Innovation and Infrastructure” of the UN’s Sustainable Development Goals (SDG). In the study, the proposed multiple-input multiple-output (MIMO) antenna is regarded as a breakthrough in wireless communication research due to its ability of greater isolation and deeper resonance while integrating multiple communications standards. The antenna’s ability to enhance channel capacity and reliability is better than other antennas of a similar type.
[article_url] => https://ieeexplore.ieee.org/document/9709264
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[doi] => https://doi.org/10.1109/ACCESS.2022.3150348
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[publication_title] => Bandstop Filter Decoupling Technique for Miniaturized Reconfigurable MIMO Antenna
[journal_title] => IEEE Access
[publisher] => IEEE Explore
[year] => February 2022
[subject] => Electronics and Communication Engineering; Wireless Communication Systems
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[post_date] => 2022-07-14 14:36:34
[post_date_gmt] => 2022-07-14 06:36:34
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[post_title] => Heart Ultrasound Image as Potential Chronic Kidney Disease Diagnosis Tool
[post_excerpt] =>
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[post_name] => heart-ultrasound-image-as-potential-chronic-kidney-disease-diagnosis-tool
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[researchers_name] => GUDIGAR, Anjan
[researchers_position] => Department of Instrumentation and Control Engineering, Manipal Institute of Technology, India
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Heart.png
[researchers_profile] => https://www.researchgate.net/profile/Anjan-Gudigar-2
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[research_footprints] => Chronic kidney disease; FusionGraph embedding; Support vector machine; Ultrasound image
[graphic_abstract] =>
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[the_novelty] => This study developed a novel automated diagnostic system to detect and differentiate different stages of chronic kidney disease (CKD) using ultrasound (US) images of the heart. The proposed computer-aided diagnosis system combined image and feature fusion techniques under a graph embedding framework to characterize heart chamber properties of stage 3 to stage 5 CKD patients. Findings indicated an impressive 100% accuracy in differentiating healthy individuals from CKD patients and a 99.09% accuracy in distinguishing between multiple CKD stages with absolute specificity and sensitivity. Moreover, the utilization of non-invasive heart US imagery as part of a computer-aided diagnosis tool does not only provide a cost-effective approach for CKD staging but also would serve as reliable cardiac health surveillance among CKD patients. Thus, clinicians would be able to monitor the heart conditions of CKD patients effectively and propose early interventions as and when needed.
[the_background] => Although the widely available kidney US technique is a relatively low-cost approach to assessing CKD at all stages, it is also time-consuming. It is largely subjected to attending healthcare professionals’ interpretation. Therefore, it is necessary for an automated diagnostic tool to be utilized to improve the reliability of the assessment. Apart from that, CKD patients are known to face a higher risk of developing severe cardiovascular disease. Studies have shown that those with stage 5 CKD undergoing dialysis are 10 to 20 times more prone to the risk of cardiovascular mortality. Hence, continual cardiac assessment of CKD patients, regardless of the disease stage, is necessary to ensure timely intervention and reduce the severity of complications as well as mortality. As a result of such challenges, this study aims to improve the accuracy and sensitivity of CKD screening through automation.
[the_sdg_impact] => Globally, over 75 million people are affected by CKD, making it one of the leading public health problems. Studies have also shown that the mortality rate from CKD has increased up to 41.5% from 1990 to 2017. By developing an effective algorithm to screen for CKD progress using heart US imagery, this study improves the prevention rate of premature mortality from non-communicable diseases, mainly cardiovascular diseases. Additionally, the system is generalizable to other medical conditions, hence could potentially serve as a reliable diagnostic tool for the global burden of various other diseases. (SDG 3: Good health and well-being)
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S174680942100330X
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[doi] => https://doi.org/10.1016/j.bspc.2021.102733
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[publication_title] => Automated detection of chronic kidney disease using image fusion and graph embedding techniques with ultrasound images
[journal_title] => Biomedical Signal Processing and Control
[publisher] => Elsevier
[year] => July 2021
[subject] => Instrumentation and Control Engineering; Chronic Kidney Disease
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[post_date] => 2022-07-14 14:18:52
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[post_title] => Effect of Oleic Acid Additives on Performance and NOx Emissions in Biodiesel Engine
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[research_footprints] => Biodiesel; Hydrogen carrier; NOx; Oleic acid; Optimization; PSO
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[the_novelty] => This study discloses that the emission of oxides of nitrogen (NOx) from a biodiesel engine is minimal when running on Pongamia ester (PE) with 10% oleic acid at a compression ratio (CR) of 17.5 and engine load of 81%. Upon optimization, the NOx is reduced by 72% (100 ppm) at a 2% loss of brake thermal efficiency (BTE) (30.42%). A stationary single-cylinder, four-stroke, water-cooled, variable compression ratio (VCR) compression ignition engine is used in this study. Meanwhile, the optimization of operating conditions involves scientific methods such as the design of experiments (DOE), analysis of variance (ANOVA), regression analysis, and multiobjective particle swarm optimization (MOPSO). In order to fine-tune the current study, future research may use a biodiesel engine with higher flexibility in the variability of engine load as the current engine load can only be controlled at the steps of 25%.
[the_background] => Biodiesel is an excellent alternative for conventional combustion-based applications, such as automobiles and power plants. Pongamia oil (PE) (derived from inedible plants) is known as a highly potential source of biodiesel fuel. For better understanding, scientists compared the use of neat PE and PE blends containing diesel fuel. Although PE blends achieved higher brake thermal efficiency (BTE) and combustion duration, there was an increase in NOx emissions. To overcome that, various types of biodiesel additives and their effect have been studied. Despite that, the number of reported studies focusing on the effect of oleic acid additives (e.g., combustion performance, NOx emissions) on biodiesel is still scarce. Furthermore, no optimization study has been carried out to ascertain the optimum oleic acid concentration for the desired reduction in NOx emissions without compromising the combustion performance. Thus, this research strives to investigate the effect of oleic acid additives on the performance and NOx emissions in a PE fuel-operated biodiesel engine. Optimization of the controlling parameters is also conducted to maximize the engine efficiency and minimize NOx emission. The results of this study are valuable for the biotechnology field to provide optimal solutions in improving the efficiency of biofuel while minimizing NOx emissions.
[the_sdg_impact] => In the U.S., the burning of fossil fuels accounted for 74% of greenhouse gas emissions in 2019. This alarming scenario implies the urgent need for renewable energy before the environmental damages worsen. Despite the existence of biodiesel which is adequately efficient and less harmful, this study went the extra mile to optimize the performance and properties of biodiesel. Hence, it fulfills UNSDG 7: Affordable & Clean Energy and UNSDG 13: Climate action by increasing the share of renewable energy in the global energy mix.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0360319921019066?via%3Dihub
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[doi] => https://doi.org/10.1016/j.ijhydene.2021.05.124
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[publication_title] => NOx reduction of biodiesel engine using pongamia ester with oleic acid and optimization of operating conditions using particle swarm optimization
[journal_title] => International Journal of Hydrogen Energy
[publisher] => Elsevier
[year] => July 2021
[subject] => Mechanical and Industrial Engineering; Biodiesel
)
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[post_date] => 2022-07-14 14:06:40
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[post_title] => Benefits of Low-Temperature Annealing for Tailoring the Physical Properties of Sn-doped ZnO Thin Film
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[researchers_name] => KEKUDA, Dhananjaya
[researchers_position] => Department Of Physics, Manipal Institute of Technology, India
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[research_footprints] => Co-sputtering; Tin doped ZnO thin Films; Low temperature air annealing; Photoluminescence; XPS; Hall effect
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study reveals the effect of low-temperature annealing on the properties of tin-doped ZnO [Zn(1-x)Sn(x)O] polycrystalline thin films with a hexagonal wurtzite structure. After being annealed, significant improvement in the electrical parameters is observed. The changes in physical properties include a change in crystal orientation from (002) to (100), an increase in the crystallite sizes (when annealed at 100 °C), an enlargement of optical bandgap from 3.17 to 3.44 eV, an increase in donor-related defects such as oxygen vacancies and Zn interstitials, and an improved blue light emission. Meanwhile, the doping process brings about an increase in oxygen-related defects, a two-order decrement in the resistivity as well as a three-order increment in the carrier concentration. The thin films were grown on glass substrates using DC magnetron reactive co-sputtering techniques. The characterization techniques involved are such as X-ray diffraction (XRD), field emission scanning electron microscope (FESEM), photoluminescence (PL) analysis, X-ray photoelectron spectroscopy (XPS), and van der Pauw resistivity measurement.
[the_background] => Zinc oxide (ZnO) is a reputable Transparent Oxide Semiconductors (TOS) for electronic and photonic applications. Its conductivity can be improved tremendously using tin (Sn) dopant, which does not cause any serious lattice distortion. Past studies show that optimized annealing could enhance the overall physical properties of Sn-doped ZnO thin film. Nevertheless, to date, the number of studies focusing on low-temperature annealed Sn-doped ZnO thin film fabricated by DC magnetron reactive co-sputtering remains scanty. Therefore, this study aims to investigate the physical properties of Sn-doped ZnO thin film prepared using the said technique and examine the effect of low-temperature air-annealing. The output of this research expands the knowledge base specifically in the potential application of Sn-doped ZnO thin film as optoelectronic devices (e.g., UV photosensors and thin-film transistors).
[the_sdg_impact] => The rapid advancement of technology has led to the designs of high-technology nano-electronic devices to cater to various industrial needs and end-consumer markets. Such phenomena have created a high demand for materials with superior properties. By introducing an effective way to prepare optoelectronic materials with enhanced properties, the outcome of this study is in line with innovative prospects envisioned by UNSDG 9: Industry, Innovation & Infrastructure.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0921452621007249?via%3Dihub
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[doi] => https://doi.org/10.1016/j.physb.2021.413571
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[publication_title] => An investigation on the role of low temperature annealing on the structural, morphological, optical, and electrical properties of DC magnetron sputtered Zn(1-x)Sn(x)O thin films
[journal_title] => Physica B: Condensed Matter
[publisher] => Elsevier
[year] => March 2022
[subject] => Physics; ZnO
)
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[post_date] => 2022-07-14 13:53:03
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[post_title] => Study of Coastal Lake Sediments Using a Mineral Magnetic Approach
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[researchers_name] => WARRIER, Anish Kumar
[researchers_position] => Department of Civil Engineering and Centre for Climate Studies, Manipal Academy of Higher Education, India
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/climate.png
[researchers_profile] => https://www.researchgate.net/profile/Anish-Warrier
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[research_footprints] => Magnetic susceptibility; Magnetic grain size; Weathering; Aeolian; Lake sediments; East Antarctica
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study investigated the abundance, size and type of magnetic minerals present in a 79-cm long sediment core from a land-locked lake (L-49) in Schirmacher Oasis (SO, East Antarctica). The sediment core spans the past 43,000-years. Apart from the abundance of iron oxide minerals traced through the magnetic susceptibility data, biological processes and wind activity were also found to be significant in contributing sediments to the lake across different timescales in the region. Notably, the findings showed that the SO lakes responded well to the changing climate throughout the last glacial period and the Holocene (11700 years BP to the Present). Such reconstruction of the L-49 sediments’ glacial-interglacial climatic and environmental changes would contribute to the expansion of literature and be useful when developing regional and global climate models.
[the_background] => Since the East Antarctic Ice Sheet (EAIS) is the largest ice sheet in Antarctica, understanding its response to the changing climate is crucial to prevent or be prepared for potential climate-change-triggered environmental catastrophe. However, there is a grave shortage of data on the past behavior of the EAIS throughout the changing timescales and climate. As linkers of continental ice cores and marine sediments, the study of coastal lake sediments would shed some light on ice sheet dynamics, sea-level changes, isostasy, deglaciation, and ice sheet decay. Therefore, this study uses the properties of magnetic minerals to reconstruct glacial-interglacial climatic and environmental changes from sediments of a land-locked lake.
[the_sdg_impact] => According to the data presented by Climate.gov, the global sea level has risen to a new record high in 2020, 91.3 mm (3.6 inches) above 1993 levels. Consequently, more high-tide flooding and other environmental catastrophe are to be expected, leaving behind massive damage to the infrastructure and disrupting the livelihood of many. By providing up-to-date and comprehensive data on the glacial conditions of the largest ice sheet and its role in the rising sea levels, the findings of this study allow scientists, environmentalists, and world leaders to devise urgent and strategic action to combat climate change and minimize its damages. (SDG 13: Climate action)
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0341816221001594
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[doi] => https://doi.org/10.1016/j.catena.2021.105300
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[publication_title] => A 43-ka mineral magnetic record of environmental variations from lacustrine sediments of Schirmacher Oasis, East Antarctica
[journal_title] => CATENA
[publisher] => Elsevier
[year] => July 2021
[subject] => Civil Engineering; Climate Studies
)
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[post_date] => 2022-07-14 13:29:57
[post_date_gmt] => 2022-07-14 05:29:57
[post_content] =>
[post_title] => Novel Raman Spectroscopy Approach for Competent Cell Membrane Studies
[post_excerpt] =>
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[post_name] => novel-raman-spectroscopy-approach-for-competent-cell-membrane-studies
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[researchers_name] => BANKAPUR, Aseefhali
[researchers_position] => Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, India
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/07/Raman.png
[researchers_profile] => https://www.researchgate.net/profile/Dr-Aseefhali-Bankapur
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[research_footprints] => Molecules; Monomers; Peptides and proteins; Plasma membrane; Raman spectroscopy
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => Using an optical vortex beam, this study proposed a novel method for optically immobilizing the red blood cells (RBCs) in a favorable orientation, improving Raman analysis sensitivity in cell membrane studies for higher cell volume. An extensive spectral analysis using the optical vortex beam was compared with the conventional Gaussian beam-based measurements to validate both efficiency and sensitivity of the method proposed. As a result, the optical trapping of RBC in a face-on orientation enabled physiological and biochemical properties of hemoglobin (Hb) molecules near RBC membrane as well as inside the bulk of the cell to be distinguished precisely. Such evidence is crucial to unravel the elaborate potentials of Raman spectroscopy in cellular studies and disease development.
[the_background] => Understanding the role of cell membranes in cellular homeostasis is vital to prevent the development of several non-communicable diseases. The conventional optical immobilization of single functional cell using Gaussian beam limits Raman spectroscopy's potential in efficiently analyzing cell membrane. Such is primarily due to the restrictions in cell orientation with regards to the beam direction and cell volume. Therefore, the study aims to provide a feasible replacement of the beam used in Raman spectroscopy to improve cell membrane analysis and understanding.
[the_sdg_impact] => Over the years, the usefulness of Raman spectroscopy as a non-invasive diagnostic tool for a range of diseases has been well established, not without its limitations. The new method proposed in this study, which utilizes an optical vortex beam instead of a Gaussian beam, enhances the performance of Raman spectroscopy in terms of cell membrane analysis. Based on the outcomes, it is apparent that such innovation could broadly impact the future development of medicines for communicable and non-communicable diseases as envisioned in the 3rd United Nations' Sustainable Development Goal, Good health and well-being.
[article_url] => https://pubs.acs.org/doi/10.1021/acs.analchem.0c05204
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[doi] => https://doi.org/10.1021/acs.analchem.0c05204
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[publication_title] => Optical Trapping and Micro-Raman Spectroscopy of Functional Red Blood Cells Using Vortex Beam for Cell Membrane Studies
[journal_title] => Analytical Chemistry
[publisher] => ACS Publication
[year] => March 2021
[subject] => Molecular Physics; Chemistry
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[post_author] => 154
[post_date] => 2022-07-14 12:29:07
[post_date_gmt] => 2022-07-14 04:29:07
[post_content] =>
[post_title] => Impact of Investor-Agent Relationship in Choosing Life Insurance Policy
[post_excerpt] =>
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[post_name] => impact-of-investor-agent-relationship-in-choosing-life-insurance-policy
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[researchers_name] => SHETTY, Ankitha
[researchers_position] => Department of Commerce, Manipal Academy of Higher Education, India
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[research_footprints] => Decision making; Insurance; Trust; Investors; Agent; Relational selling
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => To better understand investors’ buying decisions in life insurance, this study discloses how the investor-agent relationship affects the decision-making process. Trust is among the most influential prerequisites as it fully mediates the effect of agent disclosure and personal rapport on decision-making. Besides that, interaction intensity with agents, co-operative intentions of agents, and sharing of overt and covert information also significantly impact the decision-making process. These insights are derived from a questionnaire answered by 813 policyholders of life insurance companies operating in South India. A partial least square method of structural equation modeling is applied to analyze the data. Future research can expand the study scope of relational selling by focusing on adaptive and team selling behavior and diving into health insurance, auto insurance, and property insurance.
[the_background] => The chances of closing deals in the insurance industry depend mainly on the potential investors’ confidence and trust in the insurance agents responsible for providing valuable and accurate policy information. Although the ethical conduct of agents is known to be a primary determining factor, the effect of investor‒agent relationships on the decision-making process of acquiring insurance policy remains unclear. Hence, this study investigates the impact of relational selling behavior on insurance decision-making and explores the significance of trust in making such decisions. The outcome would provide valuable inputs to insurance companies by highlighting the key relational prerequisites to be emphasized while establishing and maintaining a fruitful long-term relationship with investors.
[the_sdg_impact] => The development of the insurance sector is crucial to the general economic growth of the nation by generating long-term financial resources and employment. Thus, the profitability of the insurance sector ought to be a main national financial agenda. This study has successfully identified the effect of relational selling on life insurance decision-making in India. As the ultimate focus is directed toward promoting sustainable economic growth, the study is well-aligned with UNSDG 8: Decent Work & Economic Growth.
[article_url] => https://www.emerald.com/insight/content/doi/10.1108/IJBM-09-2018-0236/full/html
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[publication_title] => The effect of relational selling on life insurance decision making in India
[journal_title] => International Journal of Bank Marketing
[publisher] => Emerald Publishing
[year] => June 2019
[subject] => Social Science; Insurance
)
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[post_date] => 2022-07-14 12:20:39
[post_date_gmt] => 2022-07-14 04:20:39
[post_content] =>
[post_title] => Life Insurance Industry: Efficiency of Traditional & Corporate Agents
[post_excerpt] =>
[post_status] => publish
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[post_name] => life-insurance-industry-efficiency-of-traditional-corporate-agents
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[research_footprints] => Bancassurance; traditional agents; insurance companies; cost efficiency; data envelopment analysis
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => Upon assessing the technical efficiency of traditional and corporate agents in the Indian life insurance industry, this study concludes that there is no significant difference between the efficiency scores of traditional and corporate agents. These findings also indicate that efficiency scores and market share are not necessarily negatively correlated, opposing the Quiet life hypothesis. The research is conducted by examining the sales efficiency of 12 traditional and corporate agency channels between 2012 and 2016 using the non-parametric approach of data envelopment analysis (DEA). By minimizing the non-availability of data and increasing the sample size, a more accurate and comprehensive outcome can be expected in future studies.
[the_background] => The profitability of the life insurance industry in India relies strongly on the efficiency of the distribution channels, such as traditional and corporate agencies. However, these agencies are bound to face difficulties like high turnover rate, increasing expenses, and unsatisfying sales figures. Thus, to confront these issues, this study is carried out to focus on the efficiency of insurance distribution channels. Based on the proven low efficiency of both the traditional and corporate media, this study suggests that insurance companies should reduce the number of agents and commission expenses. The output of this research serves as a solid reference for future strategizing and efficiency improvement of distribution channels, including leveraging digital insurance as an alternative distribution channel.
[the_sdg_impact] => The insurance industry is essential for the stability of financial systems because they are part of the prominent investors in financial markets and because the insurers safeguard the financial stability of households and firms by insuring their risks. Therefore, the sustainability and profitability of the insurance industry are critical to the economic growth of a country. By attempting to strengthen the capacity and improve the efficiency of the insurance industry, this study aligns with the targets of UNSDG 8: Decent Work & Economic Growth.
[article_url] => https://journals.sagepub.com/doi/10.1177/0972150917749722
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/07/Insurance-2.jpg
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[doi] => https://doi.org/10.1177/0972150917749722
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[publication_title] => Assessing the Technical Efficiency of Traditional and Corporate Agents in Indian Life Insurance Industry: Slack-based Data Envelopment Analysis Approach
[journal_title] => Global Business Review
[publisher] => Sage Publishing
[year] => January 2018
[subject] => Social Science; Insurance
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[post_date] => 2022-06-29 18:07:35
[post_date_gmt] => 2022-06-29 10:07:35
[post_content] =>
[post_title] => Highly-Effective Nanozymes for Biomedicine and Industrial Catalysis
[post_excerpt] =>
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[researchers_name] => ZHANG, Ruofei
[researchers_position] => Chinese Academy of Sciences, China
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[researchers_name_2] => YAN, Xiyun
[researchers_position_2] => Chinese Academy of Sciences, China
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/06/Nanozymes-2.png
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[original_article_reference] =>
[research_footprints] => Biotechnology; Chemical structure; Metals; Monomers; Peptides and proteins
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/06/AMR_Article_04_v1_EN-scaled.jpg
[figures] =>
[video] =>
[the_novelty] => By learning form natural enzymes, artificial enzymes (i.e. nanozymes) synthesized using nanomaterials have high potential in achieving or even surpassing the catalytic effectiveness of natural enzymes. Based on the role of amino acids in the active sites of natural enzymes, a desirable catalytic microenvironment can be prepared for nanozymes via simulations. Besides, nanozymes could possess adjustable enzyme-like activities by having coordination structures which are developed according to natural enzymes’ chemical coordination principles. To realize a more ideal nanozyme, future studies could focus on improving the specificity of catalysis as well as the flexibility and variability of active sites.
[the_background] => Nanozymes are artificial enzymes prepared using nanomaterials. They exhibit outstanding properties such as high stability, adjustable catalytic activities, wide range of functionality, high recyclability, and highly feasible for large-scale production. Although there has been significant progress, further optimizations are necessary so as to put nanozymes into applications. With the hope to inspire and to gain more attention from researchers, this study discusses the omnidirectional simulation of natural enzymes from an amino acid microenvironment to metal-free architecture, and to a metal coordination structure. The research output boosts the materialization of highly effective and highly efficient nanozymes which will bring biomedicine and industrial catalysis to a whole new level.
[the_sdg_impact] => Despite the rapid advances of medical science, an effective cure is still in need to treat inherited metabolic disorders which result in a number of life-changing or life-threatening conditions. The achievement of this study paves a clear path and direction as well as creates a realistic hope for the future development of nanozymes research (UNSDG 9: Industry, Innovation & Infrastructure). By being proactive in optimizing the development of nanozymes, patients of inherited metabolic disorders would stand higher chance to recover and live like any other individuals (UNSDG 3: Good Health & Well-Being).
[article_url] => https://pubs.acs.org/doi/abs/10.1021/accountsmr.1c00074
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/06/Nanozymes-4.jpg
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[doi] => https://doi.org/10.1021/accountsmr.1c00074
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[publication_title] => Nanozymes Inspired by Natural Enzymes
[journal_title] => Accounts of Materials Research
[publisher] => ACS Publication
[year] => June 2021
[subject] => Material Science
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[post_date] => 2022-06-29 17:44:02
[post_date_gmt] => 2022-06-29 09:44:02
[post_content] =>
[post_title] => Dip-Coating for Fabrication of Microstructured Ultrathin Organic Semiconductor Film
[post_excerpt] =>
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[researchers_position] => Shenzhen University, China
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/06/Semiconductor.png
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[researchers_name_2] => WANG, Shuguang
[researchers_position_2] => Tianjin University, China
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[original_article_reference] =>
[research_footprints] => Microstructures; Molecular structure; Molecules; Monolayers; Optoelectronics; Solution chemistry; Solvents
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/06/AMR_Article_03_v3_EN-scaled.jpg
[figures] =>
[video] =>
[the_novelty] => With the aim to realize state-of-the-art organic semiconductor (OSCs) via dip-coating, this study has comprehensively discussed the assembly strategy, underlying mechanism, critical factors, and applications of microstructured ultrathin organic semiconductor films (MUOSFs). The critical factors are such as pulling speed, molecular structures, and solution properties. The fundamental rule in preparing MUOSFs with different kinds of molecules (for different purposes) is to focus on the nucleation rate, assembly rate, and recession rate. Such rule will bring balance between the critical factors and, in turn, leads to fabrication of one-dimensional microstripes and two-dimensional films. By applying in-depth knowledge of dip-coating, this study has successfully prepared uniform, continuous, highly ordered, and large-area MUOSFs with monolayer precision.
[the_background] => The potential of organic electronics is proven by the successful commercialization of active-matrix organic light-emitting diodes (OLEDs) for high-end smartphone displays. This milestone has gained OSCs tremendous attention which gave rise to the ambition of further enhancing the properties and performance of OSCs. As ultrathin OSC microstructures comprise one to several molecular layers (i.e. microstructured ultrathin organic semiconductor films (MUOSFs)), a highly controlled assembly method is in high demand to improve and design the OSCs’ properties for different applications. Aiming at the molecular-level precision of dip-coating technique, this study emphasizes on the assembly strategy, the underlying mechanism, and potential applications of MUOSFs. The output of this study plays a significant role in facilitating future research on optimizing the properties and performance MUOSFs.
[the_sdg_impact] => OSCs have promising prospects for use in various electrical and optoelectric devices such as solar cells, transistors, photodetectors, and lasers. With the advantages of being eco-friendly, lower-cost and flexible, the advances of OSCs will be a game-changer for the development of electronic devices. This study supports and enhances the research related to OSCs and, hence, it fulfils UNSDG 9: Industry, Innovation, and Infrastructure.
[article_url] => https://pubs.acs.org/doi/10.1021/accountsmr.0c00042
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/06/Semiconductor-3.jpg
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[doi] => https://doi.org/10.1021/accountsmr.0c00042
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[publication_title] => Microstructured Ultrathin Organic Semiconductor Film via Dip-Coating: Precise Assembly and Diverse Applications
[journal_title] => Accounts of Materials Research
[publisher] => ACS Publication
[year] => November 2020
[subject] => Material Science
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[post_date] => 2022-06-29 17:25:41
[post_date_gmt] => 2022-06-29 09:25:41
[post_content] =>
[post_title] => Structural Design and Recent Advances of Eu2+-doped Silicates Phosphors for LED Applications
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[researchers_name] => ZHAO, Ming
[researchers_position] => Beijing University of Technology, China
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[researchers_name_2] => ZHANG, Qinyuan
[researchers_position_2] => South China University of Technology, China
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[research_footprints] => Color; Crystal structure; Crystals; Luminescence; Phosphors; LED
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/06/AMR_Article_02_v2_EN-scaled.jpg
[figures] =>
[video] =>
[the_novelty] => This study has revealed the crucial structural engineering to effectively develop Eu2+-doped silicates phosphors for LED applications. The distinctive luminescence properties of Eu2+ are attributed to the centroid shift of the 5d levels subshell, the energy difference between the lowest and highest 5d levels (crystal field splitting), the energy difference between the maximum of the lowest excitation band and that of the emission band (stoke shift), as well as the broad emission bandwidth. Therefore, the Eu2+ emission in silicates can possibly be tuned via various structural strategies, such as substitutions (to modify the chemical composition and crystal structure), identifying an optimal crystallographic site for Eu2+, and controlling crystalline phase transition. The results are diverse when different crystal structures and/or local structures are involved. The progress of recent research focusing on daily applications has been outlined comprehensively. These applications include white LED lighting, liquid-crystal displays (LCD) LED backlights, and near-infrared LEDs for medical and night-vision use. In order to keep advancing of Eu2+-doped silicates phosphors for emerging LED applications, future studies can focus on the deeper understanding on the relationship of structural rigidity and Eu2+ luminescence, as well as the discovery of new phosphor sytems.
[the_background] => Although phosphor-converted light-emitting diodes (pc-LEDs) have been commonly used, there is still room for improvement for its performance which mainly relies on the luminescence properties of phosphors used. Meanwhile, besides being low cost, Eu2+-doped earth abundant silicates phosphors are excellent luminescent materials for optoelectronic applications. With tunable bandwidth, their emission colors can cover near-ultraviolet (n-UV) to near-infrared (NIR). Due to its high potential, scientists are aspired to push the limits of Eu2+-doped silicate phosphors in materializing the state-of-the-art LED applications. This study contributes by shedding light on the significant structure−property relationships and the Eu2+ photoluminescence mechanism. Such effort would facilitate researchers in developing higher-performance Eu2+-doped phosphors to cater emerging applications.
[the_sdg_impact] => The global LED lighting market reached a value of US$ 84 Billion in 2020. The high global market demand indicates the importance of LED for diverse applications (both industrial- and consumer-use). By focusing on pushing the limits of LED using Eu2+-doped silicates phosphors, this study shows good alignment with UNSDG9: Industry, Innovation & Infrastructure. Cutting-edge LEDs will directly enhance the features and performance of countless devices and equipment.
[article_url] => https://pubs.acs.org/doi/10.1021/accountsmr.0c00014
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/06/Phosphors4.jpg
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[doi] => https://doi.org/10.1021/accountsmr.0c00014
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[publication_title] => Structural Engineering of Eu2+-Doped Silicates Phosphors for LED Applications
[journal_title] => Accounts of Materials Research
[publisher] => ACS Publication
[year] => October 2020
[subject] => Material Science
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[post_date] => 2022-06-15 09:42:58
[post_date_gmt] => 2022-06-15 01:42:58
[post_content] =>
[post_title] => Opportunistic Lung Cancer Screening: Good or Bad?
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[researchers_name] => GAO, Wayne (高志文)
[researchers_position] => Global Health Security Research Center, Taipei Medical University, Taiwan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/06/tomography-.png
[researchers_profile] => https://www.researchgate.net/profile/Wayne-Gao-3
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[research_footprints] => Overdiagnosis; Observational study; Lung cancer screening; Randomized trial; Cohort study
[graphic_abstract] =>
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[video] =>
[the_novelty] => This study highlights the adverse effects of opportunistic lung cancer screening promotion from the non-smoking Taiwanese women population perspective. Findings indicate that the rise of low dose computed tomography (LDCT) screening among low-risk women population led to 6 times higher early-stage lung cancer detection from 2004 to 2018 with no change in the incidence of late-stage lung cancer. Even with a consistent lung cancer mortality, the 5-year survival rate has more than doubled within the given period. This concludes the potential misleading feedback that follows unnecessary excessive cancer screening. Without dismissing the benefits of LDCT screening for lung cancer, the study suggests the target groups be heavy-smoker specific for better reliability instead of broad low-risk population screening.
[the_background] => Over the years, lung cancer screening criteria have expanded, and opportunistic screening for the disease has been actively promoted among lower-risk groups. Increased incidence of lung cancer has been reported even as the smoking population and other risk factors continue to decrease. Considering these observations, researchers find that it is crucial to understand the association of lung cancer incidence with the promotion of screening in a predominantly non-smoking population. Potentially, the findings would highlight the health and economic impacts as well as reliability of opportunistic screening among lower-risk groups, serving as an important reference for healthcare policymakers.
[the_sdg_impact] => According to WHO, in 2020 alone, out of 2.21 million lung cancer cases reported, there were approximately 1.80 million deaths. Apart from prevention efforts, early detection is believed to play a prominent role in reducing cancer mortality. Consequently, opportunistic screening has been heavily promoted, not just among heavy smokers, but also among those from the lower-risk population. However, this study’s findings elaborated on the adverse effects of such excessive screening and the economic impact on national insurance coverage as a result of overdiagnosis and downstream medical procedure expenses. Accordingly, healthcare policymakers could refer to these findings for a better decision-making process concerning health coverage, and quality and affordability of medical services. (UN SDG 3: Good health and well-being)
[article_url] => https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2788296
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[doi] => https://doi.org/10.1001/jamainternmed.2021.7769
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[publication_title] => Association of Computed Tomographic Screening Promotion With Lung Cancer Overdiagnosis Among Asian Women
[journal_title] => JAMA Internal Medicine
[publisher] => JAMA Network
[year] => January 2022
[subject] => Medical; Lung Cancer; Social Science
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[post_date] => 2022-06-07 22:57:47
[post_date_gmt] => 2022-06-07 14:57:47
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[post_title] => Low-background Neutron Detector for Precise Measurement of Reaction Cross-Section
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[researchers_name] => LI, Yutian (李宇田)
[researchers_position] => CAS Key Laboratory of High Precision Nuclear Spectroscopy, Institute of Modern Physics, Chinese Academy of Sciences, China
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[researchers_name_2] => GAO, Bingshui Gao
[researchers_position_2] => CAS Key Laboratory of High Precision Nuclear Spectroscopy, Institute of Modern Physics, Chinese Academy of Sciences, China
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[research_footprints] => Underground laboratory; Neutron detector; Low background; 3He Counter
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/06/2022_NST_Article_04_v1_EN-scaled.jpg
[figures] =>
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[the_novelty] => This study has successfully developed a high-efficiency neutron detector array with an exceptionally low background to measure the cross-section of the 13C(α,n)16O reaction at the China Jinping Underground Laboratory (CJPL). Comprising 24 3He proportional counters embedded in a polyethylene moderator, and shielded with 7% borated polyethylene layer, the neutron background at CJPL was as low as 4.5 counts/h, whereby 1.94 counts/h was attributed to the internal α radioactivity. Remarkably, the angular distribution of the 13C(α,n)16O reaction was proven to be a primary variable affecting the detection efficiency. The detection efficiency of the array for neutrons in the range of 0.1MeV to 4.5 MeV was determined using the 51V(p, n)51Cr reaction carried out with the 3 MV tandem accelerator at Sichuan University and Monte Carlo simulations. Future studies can be planned to focus on further improvement of the efficiency accuracy by measuring the angular distribution of 13C(α,n)16O reaction.
[the_background] => Gamow window is the range of energies which defines the optimal energy for reactions at a given temperature in stars. The nuclear cross-section of a nucleus is used to describe the probability that a nuclear reaction will occur. The 13C(α,n)16O reaction is the main neutron source for the slow neutron capture process (s-process) in asymptotic giant branch (AGB) stars, in which the 13C(α,n)16O reaction occurs at the Gamow window spanning from 150 to 230 keV. Hence, it is necessary to precisely measure the cross-section of 13C(α,n)16O reaction in this energy range. A low-background and high detection efficiency neutron detector is the essential equipment to carry out such measurements. This study developed a low-background neutron detector array that exhibited high detection efficiency to address the demands. With such development, advanced studies, including direct cross-section measurements of the key neutron source reactions in stars, can be conducted in the near future.
[the_sdg_impact] => Low-background neutron detectors play a crucial role in facilitating research related to nuclear astrophysics, neutrino physics, and dark matter. By improving the efficiency and upgrading the technological capability of low background neutron detectors, this study indirectly contributes to the enhancement of scientific research. Additionally, fields involving material science and nuclear reactor technology would also benefit from the perfection of neutron detector technology. Taking into consideration the potential application and expansion of these findings, such innovative attempt aligns well with UNSDG9: Industry, Innovation & Infrastructure.
[article_url] => https://link.springer.com/article/10.1007/s41365-022-01030-0
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[publication_title] => Development of a low-background neutron detector array
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => April 2022
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_title] => Hadronic Interactions and Collective Flow in High-Baryon-Density Region
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[researchers_name_2] => SHI, Shusu
[researchers_position_2] => College of Physical Science and Technology, Central China Normal University, China
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[original_article_reference] =>
[research_footprints] => Heavy-ion collisions; QCD phase diagram; UrQMD; Collective flow; Mean-field potential
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/06/2022_NST_Article_03_v2_EN-scaled.jpg
[figures] =>
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[the_novelty] => This study showed the significance of hadronic interactions in developing collective flow in the high-baryon-density region. The statement was derived from the finding whereby a mean-field mode with strong repulsive interaction is needed to reproduce the recent STAR results of 10–40% centrality at √sNN = 3 GeV. Besides that, the energy dependence of directed and elliptic flows was discussed comprehensively. The research was conducted based on Monte Carlo event samples of Au+Au collisions at center of mass energies of √ sNN = 2.11 – 4.9 GeV generated by version 3.4 of the UrQMD model (including both cascade and mean-field modes). These findings contribute to a richer knowledge base in particle physics.
[the_background] => High-energy (relativistic) heavy-ion collisions produce an enormous amount of subatomic particles in all directions. In such collisions, the term “flow” describes how energy, momentum, and number of these particles vary with direction. Collective flow describes a movement of a large number of subatomic particles either in a common direction or at a common magnitude of velocities. Meanwhile, elliptic flow measures how the flow is not uniform in all directions when viewed along the beamline. Besides proving the existence of quark-gluon plasma, elliptic flow is one of the most important observations measured at the Relativistic Heavy Ion Collider (RHIC). A recent study conducted by Solenoidal Tracker at RHIC (STAR) implied that the hadronic interactions dominated the equation of state in collisions at center of mass energies of √ sNN = 3 GeV (a region with a high baryon density baryon chemical potential of 750 MeV). As an effort to explore phase structure in the high baryon density region, this research deployed a hadronic transport model, known as the ultra-relativistic quantum molecular dynamics model (UrQMD), to study the directed and elliptic flows in the high baryon density region by using Monte Carlo event samples of Au+Au collisions. Other than marking a new milestone for the second phase of the beam energy scan at the RHIC (BES-II) program, the outcome paves the path to understanding experimental data from upcoming experimental facilities focused on the high baryon density region.
[the_sdg_impact] => A better understanding of the properties of the high baryon density region is essential in facilitating future research related to particle physics. This is crucial as the advancement of particle physics will directly impact the expansion of nuclear physics and other closely connected fields. In extension, such enhancement of advanced physics research contributes to the realization of 9th UNSDG: Industry, Innovation & Infrastructure.
[article_url] => https://link.springer.com/article/10.1007/s41365-022-01006-0
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[doi] => https://doi.org/10.1007/s41365-022-01006-0
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[publication_title] => Anisotropic flow in high baryon density region
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => February 2022
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
)
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[post_date] => 2022-05-23 12:42:56
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[post_title] => Improving Energy Production from the Digestion Process of Palm Oil Mill Effluent (POME)
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[researchers_name] => WONG, Lai Peng
[researchers_position] => Department of Environmental Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Malaysia
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[researchers_name_2] => MOHAMED, Hasnain Isa
[researchers_position_2] => Civil Engineering Programme, Faculty of Engineering, Universiti Teknologi Brunei, Brunei
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[original_article_reference] =>
[research_footprints] => Anaerobic digestion; Biogas; Palm oil mill effluent; Mesophilic temperature; Ultrasound
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S0048969720313450-ga1_lrg.jpg
[figures] =>
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[the_novelty] => The novelty of this research is observed in its contribution in enhancing the energy (biogas) production in the standard waste treatment of POME, highly polluted wastewater, through the ultrasonication pre-treatment. The standard waste treatment of POME involves the anaerobic digestion process that produces energy (biogas) as its main outcome. By incorporating the proposed pre-treatment method, the researchers found that POME particle size reduced while its organic surface matter increased for microbial degradation. Additionally, the metabolic activity of anaerobes involved in the digestion process is also reported to increase. These findings conclude that the ultrasonication pre-treatment is promisingly effective as it enhances anaerobic digestion and increases biogas production rates at 30 oC to 35oC. Therefore, this research not only enhances energy production from waste materials but also improves the standard waste treatment method, facilitating multiple stakeholders in strategizing the promotion and practice of generating energy from waste more effectively in the future.
[the_background] => To reduce dependence on fossil fuels, renewable energy sources are effective alternatives in overcoming this issue. While there are various forms of renewable energy, an upcoming clean and promising renewable energy is biogas obtained from the anaerobic digestion process. This same process is used to treat POME, making POME a high potential renewable energy source in Malaysia since it is one of the country’s primary commodities. The standard treatment of POME is also lower when compared to other alternatives, prompting a large amount of work focusing on the use of POME as a cheap source for biogas production. However, limited attention has been paid to enhancing the biogas production process itself, motivating the researchers to fill this gap by investigating the use of ultrasound as pre-treatment and identifying the optimum temperature range – an important parameter in the digestion process.
[the_sdg_impact] => The economy of a region is largely dependent on its energy reservoir, where fossil fuels remain the main source of energy. However, Shell International predicts that by 2050, 30% of global primary energy consumption will consist of renewable energy. Thus, the use of renewable energy is a future imperative, requiring relevant parties to ensure the production efficiency of these resources. In improving the conversion process of waste to energy, this research proposes a valuable, sustainable strategy, closely aligning with UNSDG 7: Affordable and Clean Energy. Centering on POME, a source of modern energy, this research further enables clean and efficient energy usage.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0048969720313450?via%3Dihub
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[doi] => https://doi.org/10.1016/j.scitotenv.2020.137833
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[publication_title] => Improved anaerobic digestion of palm oil mill effluent and biogas production by ultrasonication pretreatment
[journal_title] => Science of The Total Environment
[publisher] => Elsevier
[year] => June 2020
[subject] => Environmental Engineering; Biogas
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[post_date] => 2022-05-23 12:31:49
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[post_title] => Improving the Generation of Solar Power through the Optimisation of Solar Farm Layout
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[researchers_name] => TAN, Ming Hui
[researchers_position] => Department of Environmental Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Malaysia
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[researchers_name_2] => CHONG, Kok Keong
[researchers_position_2] => Department of Electrical and Electronic Engineering, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[research_footprints] => concentrator photovoltaic (CPV) system; solar power; computational algorithm; solar power plants; electricity
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S0038092X20305181-ga1_lrg.jpg
[figures] =>
[video] =>
[the_novelty] => When it comes to solar power, the conventional generating system has evolved to include an increasingly popular alternative, the concentrator photovoltaic (CPV) system, as it is highly efficient in converting power (46%). CPV systems require an appropriate layout design that involves massive land utilization, thereby increasing the cost to function optimally. These consequences must be reduced if solar energy is to be implemented and adopted worldwide. Therefore, this study attempt to mitigate these consequences by developing a computational algorithm in the MATLAB platform capable of precisely estimating and optimizing the levelized cost of electricity (LCOE) of a CPV field layout using local meteorological data. As a result, the proposed computational method can facilitate various stakeholders such as researchers and engineers to reduce the cost of implementing optimal layout design for CPV, simultaneously increasing the efficiency of generating solar power. Unlike previous works, this study also accounts for various factors that can potentially influence energy generation and cost (e.g., land cost, local meteorological data, geographical location, the land aspect ratio of CPV farms, etc.)
[the_background] => Effective space allocations in solar farms are crucial since inappropriate space design of concentrator photovoltaic (CPV) systems can cause optical losses due to the shadowing between adjacent CPV systems. Thus, capable of leading to the deterioration of the overall electrical generation of solar power plants (SPP). Such an issue can be overcome by increasing the separation distance between the adjacent CPV systems, implying a possible increase in land-related costs due to ineffective land use. Therefore, this study focused on optimizing the layout design optimization in the SPP to attain the best trade-off between land usage and energy generation using a computational algorithm.
[the_sdg_impact] => According to the US government agency, Office of Energy Efficiency and Renewable Energy, the US solar power capacity has grown to an estimated 97.2 gigawatts (GW). The International Energy Agency also projects solar energy to provide 4% of the total global electricity demand by 2023. Hence, the growing popularity of solar energy calls to attention the need for effectively designed SPP layouts to cater to this demand. This research simultaneously demonstrates its impact on UNSDG 7: Affordable and Clean Energy in contributing to this solution. It enables the accessibility and affordability of solar power by reducing costs incurred during solar power installations. Furthermore, this research potentially improves solar power generation, thereby increasing the use of renewable energy and improving global energy efficiency.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0038092X20305181?via%3Dihub
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Power-3.jpg
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[doi] => https://doi.org/10.1016/j.solener.2020.05.032
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[publication_title] => Optimization study of solar farm layout for concentrator photovoltaic system on azimuth-elevation sun-tracker
[journal_title] => Solar Energy
[publisher] => Elsevier
[year] => July 2020
[subject] => Environmental Engineering; Solar Power
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[post_date] => 2022-05-23 12:16:47
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[post_content] =>
[post_title] => Solving Deep Learning’s Overfitting via Batch Contrastive Regularization
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[researchers_name] => TAN, Hung Khoon
[researchers_position] => Department of Computer Science, Faculty of Information and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia
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[researchers_name_2] => TANVEER, Muhammad
[researchers_position_2] => Department of Computer Science, Faculty of Information and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia
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[research_footprints] => Batch contrastive loss; batch regularization; center-level contrastive loss; sample-level contrastive loss; multicenter loss; neural network
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/access-gagraphic-3110286.jpg
[figures] =>
[video] =>
[the_novelty] => This study proposed a new regularization technique known as batch contrastive regularization to address the overfitting issues in deep neural networks. When the system additionally learns to compare the similarity between similar images and dissimilarity between two unrelated images, it performs better on unseen samples, not only on training samples. The three contrastive losses involved in improving the generalization performance were centroid contrastive loss, sample contrastive loss, and multicenter loss. The two-headed network could speed up multi-task learning by having one head for classification and the other for regularization. Evaluation using the CIFAR-10 and CIFAR-100 datasets showed over 11% improvement for ResNet50 on CIFAR-100.
[the_background] => Overfitting happens whereby a system performs very well on the training set but poorly when deployed. Deeper neural networks have more parameters and would be overfitting, especially when training samples are insufficient. Previously, regularization techniques failed to enrich the model because the cross-sample information was not considered. Meanwhile, although contrastive-based regularization is promising, several limitations were identified. For the first time, an in-depth study was conducted to understand batch loss regularization for general classification tasks.
[the_sdg_impact] => Deep learning is a disruptive technology that revolutionizes many industries. It is estimated to improve 82% of the outcome metric of SDG, including manufacturing (SDG9), climate action (SDG13), and sustainable city (SDG11). There is a need to improve the way deep learning models are trained to build more effective DL systems.
[article_url] => https://ieeexplore.ieee.org/document/9529219
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[publication_title] => Regularization of Deep Neural Network With Batch Contrastive Loss
[journal_title] => IEEE Access
[publisher] => IEEE Explore
[year] => September 2021
[subject] => Computer Science; Information Technology
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[post_date] => 2022-05-23 11:55:31
[post_date_gmt] => 2022-05-23 03:55:31
[post_content] =>
[post_title] => Boosting Well-Being via Creativity
[post_excerpt] =>
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[post_name] => boosting-well-being-via-creativity
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[researchers_name] => TAN, Chee Seng
[researchers_position] => Department of Psychology and Counselling, Faculty of Arts and Social Science, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Creativity.png
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[researchers_name_2] => TAN, Cher Yi
[researchers_position_2] => Department of Psychology and Counselling, Faculty of Arts and Social Science, Universiti Tunku Abdul Rahman, Malaysia
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[research_footprints] => creativity; employees; experiment; priming; subjective well-being
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This research reported the beneficial effect of creativity on subjective well-being in two studies. The first study showed that undergraduate students and working adults with higher creativity had self-reported a higher level of well-being. Then, a subsequent study was conducted to further study the causal relationship between creativity and well-being. The second study indicated that participants who recalled their past creative achievement showed a higher level of well-being. Based on the proven bidirectional relationship between creativity and well-being, future research should consider the significance of a reciprocal relationship between two constructs.
[the_background] => Although well-being is known to promote creativity, there are insufficient in-depth studies on the effect of creativity on well-being. Meanwhile, subjective well-being focuses on both positive and negative aspects of life as well as satisfaction with life. It is different from proxies, like happiness, psychological/emotional well-being, which focuses on the positive dimension. Also, creativity is being perceived differently due to cultural differences, especially between the East and West. This study examined the positive effect of creativity on subjective well-being in the Malaysian context to address those differences.
[the_sdg_impact] => Subjective well-being is useful in appraising the well-being of populations. Meanwhile, there has been increasing acknowledgment of mental health's important role in achieving global development goals. In order to fulfill UNSDG 3 (Good health and well-being)'s vision of improving physical and psychological wellness, this study demonstrates that creativity is a promising factor to enhance well-being among young adults and working adults.
[article_url] => https://www.mdpi.com/1660-4601/18/14/7244
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[doi] => https://doi.org/10.3390/ijerph18147244
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[publication_title] => Being Creative Makes You Happier: The Positive Effect of Creativity on Subjective Well-Being
[journal_title] => International Journal of Environmental Research and Public Health
[publisher] => MDPI
[year] => July 2021
[subject] => Psychology and Counselling; Social Science
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[post_date] => 2022-05-23 11:39:43
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[post_content] =>
[post_title] => Derivation of Operational Status from Retrofitted Sensor
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[researchers_name] => OOI, Boon Yaik
[researchers_position] => Department of Computer Science, Faculty of Information and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia
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[research_footprints] => Industry 4.0; Internet of Things (IoT) for manufacturing; legacy machine monitoring; vibration analysis
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study developed an approach to automatically track and distinguish various operation statuses of legacy manufacturing machines by analyzing the vibration data collected from a retrofitted wireless vibration sensor. To test its feasibility, the parameter-free Internet-of-Things (IoT) approach was deployed on a 3-speed industrial exhaust fan in a limestone processing factory. The operation status was successfully tracked with average accuracy and standard uncertainty of 98.6% and 1.06%, respectively. This promising approach could be applied to other factories, such as palm oil refineries and concrete plants.
[the_background] => While riding the wave of Industrial Revolution (IR) 4.0, data plays a crucial role in decision-making in every business sector. However, many small and medium enterprises (SME) factories still use manufacturing machines without any computing function, let alone internet connectivity. This implies that access to operational data is limited and painstaking. To help these SMEs catch up with the IR 4.0, this study designed an end-to-end wireless IoT and parameter-free approach to capture and analyze vibration data, which outputs critical operational status. By having these data, stakeholders of the business will have a clear understanding of their machines' productivity to make better business decisions.
[the_sdg_impact] => In manufacturing, big data can include data collected at every production stage, including data from machines, devices, and operators. The data serves as a reliable guide for business planning and strategy with proper analysis and interpretation. Besides getting prepared for IR 4.0, the sensor retrofitting solution developed by this study also helps SMEs attain better operation visibility (UNSDG 9: Industry, Innovation & Infrastructure).
[article_url] => https://ieeexplore.ieee.org/document/9093061
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[doi] => https://doi.org/10.1109/JIOT.2020.2994395
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[publication_title] => A Parameter-Free Vibration Analysis Solution for Legacy Manufacturing Machines’ Operation Tracking
[journal_title] => IEEE Internet of Things Journal
[publisher] => IEEE Explore
[year] => May 2020
[subject] => Computer Science; Information Technology
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[post_date] => 2022-05-23 11:05:25
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[post_title] => Factors that Influence Switching Intention from Cash to Mobile Payment
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[researchers_position] => Department of Marketing, Faculty of Business and Finance, Universiti Tunku Abdul Rahman, Malaysia
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[researchers_position_2] => Department of Marketing, Universiti Tunku Abdul Rahman, Malaysia
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[research_footprints] => Mobile Payment; Switching Intention; Push-pull-mooring; Status quo bias; Mobile Commerce
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study determined the factors that play vital roles in the consumers' decision-making to transition from cash to m-payment. This was done via a uniquely developed conceptual model that incorporated the push-pull-mooring (PPM) framework with the perspective of status quo bias (SQB). The studied parameters were monetary value, alternative attractiveness, trust, perceived security and privacy, switching costs, traditional payment habit, and inertia. Results suggest all but two of the developed hypotheses were statically supported. This could be because most respondents do not use mobile payments daily. Thus, the cumulative financial savings would be difficult to be noticed by mobile payment users in such a situation. In conclusion, with the increase in mobile payment adoption and decrease in cash usage, cash costs can be decreased. These costs include the printing, storing, and distributing cash spent by the banks and government. These savings can provide the government with excess funds, which can be diverted to develop other sectors of the country's economy.
[the_background] => The Malaysian government has consistently promoted mobile payment adoption due to its numerous benefits and advantages, including enhancing customers' checkout experience. However, consumers in Malaysia still find it more comfortable using cash to make payments for goods and services despite initiatives to shift Malaysia into a cashless society. Apparently, cash is still king among the payment methods available despite the urge from authorities. Hence, this study looks into the factors influencing switching intention from cash to mobile payment.
[the_sdg_impact] => In Malaysia, there is a solid foundation for m-payment to thrive as the number of mobile connections in terms of the total population is at 125% (We Are Social, 2019). In fact, the Central Bank of Malaysia has been trying to accelerate the promotion of m-payment adoption as it recognizes the numerous benefits of m-payment (Bank Negara Malaysia, 2018). However, consumers have a certain level of hesitancy concerning these initiatives. Therefore, the outcome of this study contributes to SDG9: Industry, Innovation, and Infrastructure as it explores means to understand consumer behavior and willingness to adapt to the shifting payment method initiatives.
[article_url] => https://www.emerald.com/insight/content/doi/10.1108/INTR-04-2020-0175/full/html
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[publication_title] => Switching from cash to mobile payment: what's the hold-up?
[journal_title] => Internet Research
[publisher] => Emerald Publishing
[year] => February 2021
[subject] => Business; Marketing
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[post_date] => 2022-05-23 10:50:40
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[post_title] => New Path-Finding Strategy to Design Smarter Drones
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[researchers_name] => TAN, Lyk Yin
[researchers_position] => "Faculty of Information and Communication Technology Department of Computer and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia
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[researchers_name_2] => GOH, Hock Guan
[researchers_position_2] => "Faculty of Information and Communication Technology Department of Computer and Communication Technology, Universiti Tunku Abdul Rahman, Malaysia
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[original_article_reference] =>
[research_footprints] => Wireless network; mobile sink; efficient path; data collection
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study introduced a new path-finding strategy, known as Energy-efficiency Path-finding Strategy (EPS) in the Air-Ground Collaborative Wireless Sensor Network (AGCWSN), which could potentially enhance the efficiency of data collection for drones. Two phases were involved in this study, i.e., intermediate point selection phase and path selection phase. The intermediate points among the group sensor nodes allowed the drone to collect data rapidly (reduced flight distance). Generic Algorithm (GA) shortened the flight path generation time in the path selection phase. It archived the pre-set condition (e.g., maximized data collection and returned to the base station before its power was drained out). Compared to other existing data collection strategies, EPS achieved lower data delivery delay and better utilization of the mobile sink’s battery capacity, as simulations showed. These two major advantages could compensate for its higher packet loss percentage. By implementing this improvement, data collection efficiency in flight path generation and energy consumption for drones can be significantly enhanced.
[the_background] => Drones are being deployed into different industries to improve productivity and efficiency. For example, Amazon deploys drones in their delivery system to shorten the last-mile delivery process, while drones in sustainable agriculture can reduce the data collection delays. However, one of the main drawbacks is the limited battery capacity of the drone during its flight. In this study, the data collection process of a drone in agriculture will be further improved by optimizing the energy usage of the drones and by shortening the flight trajectory taken by the drones. Despite having several reported approaches which shortened the delays, the flight trajectory taken by the mobile sink has not been addressed yet. Thus, this study proposed a new path-finding strategy to overcome that.
[the_sdg_impact] => As industrialization advances rapidly, drones play essential roles in maximizing productivity. Their potential has been proven especially in goods delivery and sustainable agricultural activities. The solutions proposed by this research can boost the productivity and operating duration of drones. Therefore, it contributes to the materialization of UNSDG 9’s target, i.e., build resilient infrastructure, promote inclusive and sustainable industrialization, and foster innovation.
[article_url] => https://www.techscience.com/cmc/v67n3/41619
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[doi] => https://doi.org/10.32604/cmc.2021.015402
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[publication_title] => An Energy-Efficient Mobile-Sink Path-Finding Strategy for UAV WSNs
[journal_title] => Computers, Materials, & Continua
[publisher] => Tech Science Press
[year] => March 2021
[subject] => Information and Communication Technology; Drones
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[post_date] => 2022-05-23 10:40:17
[post_date_gmt] => 2022-05-23 02:40:17
[post_content] =>
[post_title] => Transport EKC Analysis with Corruption as an Impacting Variable from 1990-2017 in Malaysia
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[researchers_name] => GO, You How
[researchers_position] => Department of Economics, Faculty of Business and Finance, Universiti Tunku Abdul Rahman, Malaysia
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[researchers_name_2] => LAU, Lin Sea
[researchers_position_2] => Department of Economics and Administrative Sciences, Attar Institute of Higher Education, Iran
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[research_footprints] => Environmental Kuznets curve hypothesis; Carbon dioxide emissions; Transport sector; Corruption; Malaysia
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study intends to analyze the association between transport carbon dioxide (CO2) emission and corruption practice and validate the Environmental Kuznets curve (EKC) hypothesis in the Malaysian context. This study adopted fully modified ordinary least squares, canonical cointegrating regression, and dynamic ordinary least squares in performing long-run estimations to test the EKC hypothesis on the role of corruption on transport CO2 emission from 1990 to 2017 in the country. The retrospective study showed that transport CO2 emission increases directly proportionally to corruption, demonstrating environmental degradation that corruption causes. The research also identified that the EKC hypothesis does not apply in Malaysia, suggesting that the country has yet to attain the level of economic growth required to reduce greenhouse gas (GHG) emissions. The outcome of this study will be a significant tool for developing effective government policies to reduce transport CO2 emission with proper governance of the sector.
[the_background] => The transport sector is one of the major contributors to global CO2 emission, accounting for 24% of the total. In Malaysia, road transport contributes to 85.2% of the total transport emission. The local transport industry is largely intertwined with the government predisposing it to undesirable corruption practices, contributing to harmful environmental policies and misallocation of environmental resources. The outcome of this study showed such practices provide the precarious impact on the environment. If corruption is left uncontrolled, it will lead to a more harmful outcome in the long run. The study also made aware that Malaysia is far from attaining economic growth that can support CO2 emission mitigation due to the lack of advanced technology and widespread corruption in the transport sector. Hence, sustainable long-term efforts are needed to mitigate CO2 emissions from the transport industry. The efforts will include introducing stringent anti-corruption policies and laws, enhancing research and development in the transportation sector, and implementing the latest environmental-friendly technologies to reduce GHG emissions. This study is the first in the country to explore the impacts of transport EKC locally with corruption as an impacting factor, which has proven the importance of better governance on this matter.
[the_sdg_impact] => This study resonates very well with the United Nation's Sustainable Development Goal (UNSDG) 13: Climate Action. The specific target involved under the UNSDG is Target 13.2: Integrate climate change measures into national policies, strategies, and planning. Despite the study being conducted locally, the intention is applicable globally, given that climate change is an issue that is getting more attention on the global pedestal by day. The atmospheric concentrations of the major GHG continue to increase worldwide. To limit global warming to 1.5°C above pre-industrial levels following Paris Agreement, the world would need to attain net-zero carbon dioxide emissions by 2050. Locally, Malaysia's intention to cut GHG emissions by 45% by 2030 can only be achieved if the government develops a sustainable transport policy that optimally controls the traffic rate, enhances environmental performances, and creates public awareness on the impact of transport emission on the environment. Hence, this study is a wake-up call to the authorized agencies and public to do the needful to cut down GHG emissions in general to save the planet that has been home and provided us with everything.
[article_url] => https://link.springer.com/article/10.1007/s11356-020-10736-w
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[publication_title] => A transport environmental Kuznets curve analysis for Malaysia: exploring the role of corruption
[journal_title] => Environmental Science and Pollution Research
[publisher] => Springer Nature
[year] => September 2020
[subject] => Economics; Environmental; Finance
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[post_date] => 2022-05-23 10:25:28
[post_date_gmt] => 2022-05-23 02:25:28
[post_content] =>
[post_title] => The Intention to Adopt Solar Technology among Malaysian Consumers: Of Knowledge and Price Value
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[researchers_name] => CHOONG, Yuen Onn
[researchers_position] => Department of Business and Public Administration, Faculty of Business and Finance, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Adopting.png
[researchers_profile] => https://www.researchgate.net/profile/Yuen-Onn-Choong
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[researchers_name_2] => LAU, Lin Sea
[researchers_position_2] => Department of Economics and Administrative Sciences, Attar Institute of Higher Education, Iran
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[research_footprints] => Residential solar photovoltaic; Knowledge transmission; Price value; Sustainability; Unified theory of acceptance and use of technology (UTAUT); Social influence; Facilitating conditions
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => Using one of the most established technology adoption theories, UTAUT (Unified Theory of Acceptance and Use of Technology), this research examines the behavioral intention of potential consumers' in adopting solar power technology. From a social influence perspective, the researchers discovered that cost perception has a more significant positive effect than knowledge. Social influence is also revealed to have a more substantial effect on consumers' behavioral intention than other conditions supporting innovation. However, these conditions positively mediate the relationship between social influence and behavioral intention. This research provides valuable insights into consumers' perspectives on renewable solar energy, which is limited since previous studies do not specifically address the solar energy context. These insights guide multiple stakeholders such as the Malaysian government and relevant commercial suppliers on successfully promoting the use of solar energy. Some strategies highlighted by the researchers include providing financial support and sufficient information to potential consumers as well as creating favorable impressions of technology use. Additionally, this research also prompts the need for effective policies that cater to the needs of large corporations and small households, encouraging the use of renewable technology in Malaysia by allowing stakeholders at every level to contribute to the nation's sustainability plan.
[the_background] => The increase in global population and economic development has also contributed to the significant boom in electrical consumption worldwide. While non-renewable energy sources are still expected to constitute 77% of the energy consumption in 2040, renewable energy has been gaining fast traction recently, with solar power being one of the most popular sources. However, the adoption rate for solar photovoltaic technology among households remains low, prompting the researchers to focus on the reasons that influence Malaysian consumers' intention to adopt solar energy. The research accounts for the consumers' perspective and examines the influence of the price and knowledge dimensions on consumers' intention to use solar energy.
[the_sdg_impact] => Globally, fossil fuels (e.g., coal and oil) account for 70% of the increasing demand for energy (International Energy Agency, 2017), while in Malaysia, fossil fuels generate 90.6% of the nation's total electricity. This situation calls for the successful implementation of solar energy as an alternative energy source since it is considered one of the most viable forms of renewable energy. In terms of global sustainability, this research contributes to the achievement of UNSDG 7: Affordable and Clean Energy. By focusing on consumers' views on cost and information sharing on solar power, this research provides stakeholders with insights for future strategies to promote access to solar power's affordable and reliable use. These insights can also reduce the dependency on fossil fuels to ensure energy efficiency and a balanced global energy mix. Additionally, the impact of this research is also observed in relation to UNSDG13: Climate Action, where it improves the overall awareness of climate change mitigation.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0301421520303827?via%3Dihub
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[doi] => https://doi.org/10.1016/j.enpol.2020.111651
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[publication_title] => Investigating nonusers’ behavioural intention towards solar photovoltaic technology in Malaysia: The role of knowledge transmission and price value
[journal_title] => Energy Policy
[publisher] => Elsevier
[year] => September 2020
[subject] => Business and Public Administration; Solar Energy
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[post_date] => 2022-05-22 14:42:33
[post_date_gmt] => 2022-05-22 06:42:33
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[post_title] => Extraordinary Solar Energy Conversion & Heat Storage by Phase Change Material
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[researchers_name] => MUNUSAMY, Yamuna
[researchers_position] => Department of Petrochemical Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png
[researchers_profile] => https://www.researchgate.net/profile/Yamuna-Manusamy
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[researchers_name_2] => ONG, Kok Seng
[researchers_position_2] => Department of Industrial Engineering, Universiti Tunku Abdul Rahman, Malaysia
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[research_footprints] => Phase change material; Composite materials; Thermal properties; Energy storage; Conversion; Coating
[graphic_abstract] =>
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[video] =>
[the_novelty] => Unlike previous phase change material (PCM), which could only store heat, this study fabricated a PCM capable of solar energy conversion and heat storage. The visible light-harvesting PCM could absorb an enormous amount of heat and store the heat in the form of latent heat. As a result, only a smaller tank is required and eliminates solar collectors' usage. The fabrication involved dip-coating myristic acid (MA) tablets into layers of polymer coating solution with reduced graphene oxide (RGO). The highest heat storage, solar energy conversion, and storage efficiency (21%) were achieved by the light absorptive polymeric form-stable composite phase change tablet (RGO-PARB/MA) when loaded with 1.5 wt% RGO. The 1.5 wt% RGO-PARB/MA recorded up to 1,000 thermal cycles with less than 2% change in thermal properties. The new PCM can be further optimized to enhance the efficiency of existing solar heating systems.
[the_background] => The current solar water heater system uses sensible heat storage that involves a large mass of water. Since most roofs are not meant to support such load, the storage has to be built on the ground instead. This setup will, in turn, require a circulation system which ends up lowering the energy-saving efficiency. Meanwhile, PCM is suitable for thermal energy storage in solar heating systems due to its high thermal storage density and minimal temperature variation. Despite various studies focusing on improving the light absorption of PCM via the addition of light absorptive materials, there was no quantitative measurement conducted to derive the solar energy conversion and storage efficiency. Hence, besides fabricating a PCM loaded with reduced graphene oxide (RGO), this study also built a new in-house experimental setup to carry out the crucial quantitative characterizations.
[the_sdg_impact] => Renewable energy is essential to reduce the emission of greenhouse gases and to overcome pollution. This implies the urgent need for a superior energy storage system. The PCM developed in this research could set new benchmarks for solar water heater systems, benefitting both the environment and its consumers. Therefore, it aligns with the targets of UNSDG 7: Affordable & Clean Energy.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S135943111931453X?via%3Dihub
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Solar-.jpg
[podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16111096_1653201441.mp3
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[doi] => https://doi.org/10.1016/j.applthermaleng.2019.114673
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(
[publication_title] => Light absorptive polymeric form-stable composite phase change material for thermal storage
[journal_title] => Applied Thermal Engineering
[publisher] => Elsevier
[year] => May 2020
[subject] => Petrochemical Engineering; Engineering and Green Technology
)
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[post_date] => 2022-05-22 14:27:25
[post_date_gmt] => 2022-05-22 06:27:25
[post_content] =>
[post_title] => Seaweed-Probiotic Blend to Increase Survival Rate of Shrimp
[post_excerpt] =>
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[researchers_name] => WONG, Wey Lim
[researchers_position] => Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Shrimp.png
[researchers_profile] => https://www.researchgate.net/profile/Wey-Lim-Wong
[researchers_second_profile] => "https://orcid.org/ 0000-0002-2722-3517"
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[researchers_info_2] => Array
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[researchers_name_2] => LOO, Keat Wei
[researchers_position_2] => Department of Biological Science, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png
[researchers_profile_2] => https://www.researchgate.net/profile/Loo-Keat-Wei
[researchers_second_profile_2] => "https://orcid.org/ 0000-0003-1853-0352"
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[original_article_reference] =>
[research_footprints] => Antimicrobial; Early mortality syndrome; Probiotic; Seaweed; Shrimp; Synergistic
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study disclosed a shrimp feed formulation, a seaweed-probiotic blend, which could help shrimps resist acute hepatopancreatic necrosis disease (AHPND). The seaweed-probiotic blend was a combination of Bacillus species and the red seaweed, Gracilaria sp. Through in vitro studies, the seaweed-probiotic blend exhibited a synergistic antimicrobial effect against the AHPND-causing V. parahaemolyticus strain. Consistent in vivo results were obtained whereby shrimps fed with the blend were able to survive under the presence of Vibrio parahaemolyticus strain. This environmentally-friendly shrimp feed showed promising potential as an alternative to the antibiotics used in shrimp cultivation.
[the_background] => The whiteleg shrimp (Litopenaeus vannamei) is a well-known cultured shrimp. However, shrimp production was greatly reduced when AHPND caused mass mortality in the shrimp culture. Although antibiotics and probiotics are commonly used in controlling this bacterial shrimp disease, excessive use of antibiotics could adversely affect human health and environment. In developing natural alternatives to replace antibiotics, probiotics are known to be a suitable candidate. On the downside, the probiotics used are generally not of shrimp origin and, thus, reduce the efficiency of the probiotics in protecting the shrimps from pathogen infection. Meanwhile, the red seaweed, Gracilaria is a popular feed additive in Asia owing to its antibacterial effect. To have the best of both, this study investigated the antimicrobial effect of the combination of probiotics and seaweed against AHPND-causing V. parahaemolyticus. This combination has been shown to increase the survival of shrimp when the pathogens are introduced in the laboratory culture.
[the_sdg_impact] => Seafood prices keep soaring due to the increasing consumer demand. Reducing shrimp mortality due to bacterial diseases can improve shrimp supply in the market and, hence, provide high-quality and safe proteins to people. By proposing a sustainable method to lower shrimp mortality, this study contributes to the realization of UNSDG 2: Zero Hunger.
[article_url] => https://link.springer.com/article/10.1007/s12602-019-09616-8
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/shrimp5.jpg
[podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110961_1653200553.mp3
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[doi] => https://doi.org/10.1007/s12602-019-09616-8
[original_article_reference_fields] => Array
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[publication_title] => Synergistic Antimicrobial Effect of a Seaweed-Probiotic Blend Against Acute Hepatopancreatic Necrosis Disease (AHPND)-Causing Vibrio parahaemolyticus
[journal_title] => Probiotics and Antimicrobial Proteins
[publisher] => Springer Nature
[year] => November 2019
[subject] => Biological Science; Probiotics
)
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[post_date] => 2022-05-22 14:12:16
[post_date_gmt] => 2022-05-22 06:12:16
[post_content] =>
[post_title] => Jackfruit’s Peptide JFS-2 – A Promising Antioxidant
[post_excerpt] =>
[post_status] => publish
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[post_name] => jackfruits-peptide-jfs-2-a-promising-antioxidant
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[researchers_name] => WONG, Fai Chu
[researchers_position] => Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Jackfruit.png
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[researchers_second_profile] => Https://orcid.org/0000-0003-2259-1617
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[original_article_reference] =>
[research_footprints] => Arginine; Artocarpus heterophyllus; Antioxidant peptide; Diet supplement; Electrostatic interaction; Hydrogen bond; Hydrophobicity; Synergistic
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study has successfully identified two antioxidant peptide sequences from jackfruit seeds. Both peptides, JFS-1 and JFS-2, exhibited protein protection potentials, whereas only Peptide JFS-2 displayed antioxidant activity. The antioxidant properties of Peptide JFS-2 were further investigated against different pH, temperature, and gastrointestinal digestion. Results indicated that Peptide JFS-2 was a suitable candidate to be used as a food preservative agent. Future studies on the peptides may map their antioxidant properties to a wider range of industrial applications.
[the_background] => Jackfruit seeds contain higher protein contents compared to the pulp. However, the antioxidant peptides derived from jackfruit seeds have yet to be identified. On the other hand, bioactivities were observed in protein hydrolysates and bioactive peptides derived from natural sources. Therefore, this study attempted to identify and examine the bioactive peptides extracted from jackfruit seeds. Results indicated that the peptides were potential antioxidants. These findings paved the path for future studies exploring stronger natural antioxidants.
[the_sdg_impact] => Studies have shown that various serious diseases (e.g., cancers) could be prevented by having a diet rich in antioxidants, primarily provided by fruits and vegetables. Furthermore, such a diet is unlikely to cause any severe side effects. By highlighting the possibilities and feasible ways to benefit from antioxidants in fruits, this study well aligns with UNSDG 3: Good health & well-being.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0308814620317386?via%3Dihub
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Jackfruit-3.jpg
[podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110828_1653199497.mp3
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[doi] => https://doi.org/10.1016/j.foodchem.2020.127876
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[publication_title] => Identification of antioxidant peptides derived from tropical jackfruit seed and investigation of the stability profiles
[journal_title] => Food Chemistry
[publisher] => Elsevier
[year] => March 2021
[subject] => Chemical Science; Food Science
)
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[post_date] => 2022-05-22 13:55:45
[post_date_gmt] => 2022-05-22 05:55:45
[post_content] =>
[post_title] => Highly-Potential Anti-Chikungunya Virus Agents
[post_excerpt] =>
[post_status] => publish
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[post_password] =>
[post_name] => highly-potential-anti-chikungunya-virus-agents
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[researchers_name] => SIT, Nam Weng
[researchers_position] => Department of Allied Health Sciences, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Chikungunya.png
[researchers_profile] => https://www.researchgate.net/profile/Sit-Nw
[researchers_second_profile] => https://orcid.org/0000-0002-5949-491X
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[researchers_info_2] => Array
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[researchers_name_2] => CHAN, Sze Mun
[researchers_position_2] => Department of Allied Health Sciences, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Chikungunya-2.png
[researchers_profile_2] =>
[researchers_second_profile_2] => https://orcid.org/0000-0002-7820-595X
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[original_article_reference] =>
[research_footprints] => sequential solvent extraction; cytotoxicity; real-time RT-PCR; Vero cell; viral load; chikungunya; alphavirus; antiviral
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => The study identified several extracts from 8 plants with strong antiviral activity and different action modes against the Chikungunya virus. These include preventing virus entry, reducing or killing virus propagation, or even preventing further spread of the virus in the host. The modes of action were predicated by plant species and type of extractant. Infected African monkey kidney epithelial cells were used to conduct in vitro studies by applying concurrent and non-concurrent sample introduction modes. In the concurrent mode, it was observed that more extracts exhibited strong antiviral activity. Future studies should focus on the isolation of bioactive compounds as well as the mode of action.
[the_background] => Chikungunya virus spreads through the bite of infected Aedes mosquitoes. Despite being present in 114 countries and territories, there is still no effective remedy to fight the Chikungunya virus. Medicinal plants are valuable for their phytochemicals. Furthermore, they are well-known for their antiviral activities, which could tackle diseases including influenza, human immunodeficiency, and dengue virus. To address the urgent need for anti-chikungunya virus agents, this study aims to evaluate 132 extracts from 21 species of medicinal plants (from Malaysia) for antiviral activity against the Chikungunya virus. These findings implied that the full potential of medicinal plants has yet to be unveiled.
[the_sdg_impact] => Chikungunya virus was first described in the 1950s, but no licensed vaccine or specific drug has been developed to overcome the virus. Hence, there is no vaccine or specific antiviral treatment available to date. The output of this research serves as significant progress to meet the demand. Such an attempt to combat infectious diseases aligns well with the targets of UNSDG 3: Good health & well-being.
[article_url] => https://www.mdpi.com/2223-7747/10/8/1658
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Chikungunya-4.jpg
[podcast] => https://iesresearch.solutions/wp-content/uploads/2022/05/16110766_1653198738.mp3
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[doi] => https://doi.org/10.3390/plants10081658
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[publication_title] => Mode-Dependent Antiviral Activity of Medicinal Plant Extracts against the Mosquito-Borne Chikungunya Virus
[journal_title] => Plants
[publisher] => MDPI
[year] => August 2021
[subject] => Allied Health Sciences; Medicine; Chikungunya Virus
)
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[post_date] => 2022-05-22 13:45:52
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[post_content] =>
[post_title] => Nanocomposite Photocatalyst with Dual-Action in Water Sanitation
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[researchers_name] => SIN, Jin Chung
[researchers_position] => Department of Petrochemical Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Nanocomposite.png
[researchers_profile] => https://www.researchgate.net/profile/Jin-Chung-Sin
[researchers_second_profile] => http://orcid.org/0000-0002-1177-5894
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[researchers_name_2] => LAM, Sze Mun
[researchers_position_2] => Department of Environmental Engineering, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Nanocomposite-2.png
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[original_article_reference] =>
[research_footprints] => N-doped BiOBr; NiFe2O4Z-scheme; Photocatalytic degradation; Cr(VI) reduction
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S0169433221010424-ga1.jpg
[figures] =>
[video] =>
[the_novelty] => This study has successfully synthesized Z-scheme N-BiOBr/NiFe2O4 nanocomposites which acted as photocatalysts under visible light. The highest photocatalytic activity was achieved when the nanocomposite contained 15%wt of NiFe2O4. Upon 60-min irradiation, the N-BiOBr/ NiFe2O4-15 nanocomposite removed 95.9% phenol and 100% Cr(VI). Besides being magnetically separable, the nanocomposite photocatalyst could be reused up to five successive runs without compromising its catalytic efficiency. These results indicated that N-BiOBr/ NiFe2O4-15 is a new promising catalyst for environmental and energy applications.
[the_background] => Water pollution has been an alarming side-effect owing to rapid development and industrialization. The pollutants mainly comprise organic compounds and heavy metals. Past studies show that BiOBr semiconductor is a potential photocatalyst whereby its response range could be improved via nonmetallic species doping. Meanwhile, NiFe2O4 ferrite is a popular photocatalyst for which its photocatalytic efficiency can be enhanced via coupling with semiconductor materials to form Z-scheme heterojunction. Since there is no existing literature from the past that has focused on the coupling of NiFe2O4 with N-BiOBr, this study aimed to synthesize N-BiOBr/ NiFe2O4 nanocomposite and explore its potential in removing organic pollutants and heavy metals. This serves as a good reference for future studies related to advanced photocatalysis technology for environmental and energy applications.
[the_sdg_impact] => WHO foresees that, by 2025, half of the world’s population will be living in water-stressed areas. Therefore, it is of utmost importance to develop new technologies to facilitate water sanitation and ensure a sustainable supply of clean water, which is also a source of affordable and clean energy. With the newly developed photocatalyst, this study contributes to improving water quality via pollution reduction (UNSDG 6: Clean Water & Sanitation).
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0169433221010424?via%3Dihub
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Nanocomposite-3.jpg
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[doi] => https://doi.org/10.1016/j.apsusc.2021.149966
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[publication_title] => Magnetic NiFe2O4 nanoparticles decorated on N-doped BiOBr nanosheets for expeditious visible light photocatalytic phenol degradation and hexavalent chromium reduction via a Z-scheme heterojunction mechanism
[journal_title] => Applied Surface Science
[publisher] => Elsevier
[year] => September 2021
[subject] => Petrochemical Engineering; Engineering and Green Technology
)
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[post_date] => 2022-05-22 13:11:29
[post_date_gmt] => 2022-05-22 05:11:29
[post_content] =>
[post_title] => Superior Antibacterial Potential of Stingless Bee Honey
[post_excerpt] =>
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[post_name] => superior-antibacterial-potential-of-stingless-bee-honey
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[researchers_name] => NG, Wen Jie
[researchers_position] => Department of Allied Health Sciences, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Medicinal.png
[researchers_profile] => https://www.researchgate.net/profile/Wen-Jie-Ng
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[researchers_name_2] => SIT, Nam Weng
[researchers_position_2] => Department of Allied Health Sciences, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/12/nophoto.png
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[original_article_reference] =>
[research_footprints] => blossom honey; honeydew; Apis cerana; Geniotrigona; Heterotrigona; agar-well diffusion; bactericidal; endotoxin; synergistic; antibiotic resistant
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study demonstrated the extraordinary antibacterial effect of honeydew honey produced by Heterotrigona itama stingless bee. The honeydew honey exhibited antibacterial activity, including inhibitory and bactericidal effects against antibiotic-resistant strains, such as Staphylococcus aureus and Escherichia coli, in in vitro studies. Such prominent antibacterial effect of stingless bee honeydew honey was due to the interactive actions of hyperosmolarity, acidity, hydrogen peroxide, and phytochemicals together in honey. Compared to honey bee honey, stingless bee honey showed a higher success rate in bacteria inhibition, which can be further enhanced when combined with antibiotics. Due to its superior antibacterial properties, H. itama stingless bee honey is a promising natural remedy for treating bacterial infections. Hence, this product can be considered and promoted as a potential wound dressing in the health care sector.
[the_background] => Past studies reported that the antibacterial effects of honeydew honey are more superior to that of blossom honey. However, to date, the antibacterial potential of honeydew honey produced by Heterotrigona itama stingless bees from Malaysia is still ambiguous. Furthermore, only two types of honey (i.e., manuka honey and Revamil honey) are approved for medicinal use to treat infections. Thus, this study aimed to determine the potential of H. itama stingless bee honeydew honey as an antibacterial agent. So far, the studies on Malaysian stingless bee honey, especially honeydew honey, are rather limited. Hence, this investigation is useful to provide information about the antibacterial properties of this honey.
[the_sdg_impact] => As bacteria keep evolving to resist antibiotics, WHO has identified a list of bacteria for which new antibiotics are urgently needed. Honey is well-known for being an effective natural antibacterial food. Apart from being a sweetener, findings show that H. itama stingless bee honeydew honey can be promoted as a health-promoting food. With this achievement, this study supports the research and development of medicines for communicable and non-communicable diseases (UNSDG 3: Good health & well-being).
[article_url] => https://www.mdpi.com/2079-6382/9/12/871
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/Medicinal-3.jpg
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[publication_title] => The Antibacterial Potential of Honeydew Honey Produced by Stingless Bee (Heterotrigona itama) against Antibiotic Resistant Bacteria
[journal_title] => Antibiotics
[publisher] => MDPI
[year] => December 2020
[subject] => Allied Health Sciences; Medicine
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[post_title] => Effective Model for Financial Performance Assessment
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[researchers_name] => LAM, Weng Siew
[researchers_position] => Department of Physical and Mathematical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia
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[researchers_position_2] => Department of Physical and Mathematical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia
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[original_article_reference] =>
[research_footprints] => entropy; fuzzy VIKOR; multi-criteria decision making; financial ratio; research framework
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study introduced a multi-criteria decision-making (MCDM) method, known as the integrated entropy–fuzzy VIKOR model, which was feasible in assessing the financial performance of construction companies. Using this model, ECONBHD was identified as the best construction company in Malaysia in terms of financial performance. Current ratio (CR), debt to equity ratio (DER), and debt to asset ratio (DAR) were the most significant financial ratios which determined the financial performance. With its proven effectiveness, the integrated entropy–fuzzy VIKOR model could be applied in other economic sectors and be extended to other MCDM problems, such as supplier selection.
[the_background] => The construction industry in Malaysia has been making significant contributions to the country’s economic growth. However, the COVID-19 pandemic has caused major disruption to most construction projects, which in turn affected the financial performance of construction firms. Therefore, during this period, precise financial performance evaluation is essential to help the construction companies make proper decisions. The VIKOR model has been commonly used in evaluating financial performance. Despite that, it has drawbacks, especially in setting decision criteria weight. To date, there is no study conducted to investigate the financial performance among construction companies by integrating entropy and fuzzy approaches into the VIKOR model. To address the gap, this research proposed an MCDM model, known as entropy–fuzzy VIKOR model, to evaluate and compare the financial performance of several construction companies.
[the_sdg_impact] => Uncertainties, such as the COVID-19 pandemic, are influential in decision-making processes that directly affect the performance of businesses. Considering such uncertainties, a multi-criteria decision-making method is needed to accurately evaluate the financial performance of companies. The integrated entropy–fuzzy VIKOR model has been proven to be feasible for such a purpose. Thus, this study achieves UNSDG 9: Industry, Innovation & Infrastructure through enhancing scientific research
[article_url] => https://www.mdpi.com/1099-4300/23/3/320
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[doi] => https://doi.org/10.3390/e23030320
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[publication_title] => Performance Evaluation of Construction Companies Using Integrated Entropy–Fuzzy VIKOR Model
[journal_title] => Entropy
[publisher] => MDPI
[year] => March 2021
[subject] => Physical and Mathematical Science; Business
)
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[post_date] => 2022-05-22 12:31:28
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[post_title] => G. Changii Seaweed in Counteracting BPA-induced Adverse Effects
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[researchers_name] => KWONG, Phek Jin
[researchers_position] => Department of Agricultural and Food Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia
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[researchers_name_2] => TAN, Gim Cheong
[researchers_position_2] => Department of Allied Health Sciences, Universiti Tunku Abdul Rahman, Malaysia
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[original_article_reference] =>
[research_footprints] => Red seaweed; Gracilaria changii; Antioxidant; Endocrine disruptor; Bisphenol A; Reproduction
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study discovered the ability of seaweed (Gracilaria changii) extract in protecting the reproductive system of mammals from the potential adverse effects of bisphenol A (BPA). Aqueous extraction of G. changii exhibited superior antioxidant properties, surpassing that of methanol and ethanol extraction approaches. Through in vivo studies using mice exposed to BPA, improved uterine development and chances of conceiving were among the remarkable findings reported. Future studies should focus on identifying the specific bioactive compounds from this aqueous extract of G. changii to further explore its mechanism of action in counteracting the BPA at the molecular level.
[the_background] => Gracilaria changii is a type of seaweed that is often used in food production. Besides being rich in nutrients crucial for human reproduction, G. changii is also known as a strong antioxidant. Meanwhile, plasticizer bisphenol A (BPA) was proven to cause oxidative damage to the human reproductive system and pregnancy. Hence, this study was conducted to investigate the potential of G. changii extract in mitigating BPA-induced adverse effects on female reproductive function. The potential of G. changii extract as a protection against BPA was proved. These results are valuable in overcoming conceiving problems associated with plasticizer toxicity.
[the_sdg_impact] => The global fertility rate has halved over the past 50 years (ourworldindata.org). This phenomenon is partially attributed to a hostile environment. By developing an effective solution to counter the negative effect, this study fulfills UNSDG 3.9 in substantially reducing the number of illnesses from hazardous chemicals.
[article_url] => https://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=1;spage=34;epage=43;aulast=Ng
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[doi] => https://doi.org/10.4103/1995-7645.304299
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[publication_title] => Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice
[journal_title] => Asian Pacific Journal of Tropical Medicine
[publisher] => Hainan Medical University
[year] => January 2021
[subject] => Agricultural and Food Science
)
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[post_date] => 2022-05-19 19:57:12
[post_date_gmt] => 2022-05-19 11:57:12
[post_content] =>
[post_title] => Family Perception & Life of Refugee Children in Malaysia
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[post_name] => family-perception-life-of-refugee-children-in-malaysia
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[researchers_name] => KHOR, Kheng Kia
[researchers_position] => Department of Advertising, Faculty of Arts and Social Science, Universiti Tunku Abdul Rahman, Malaysia
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[researchers_name_2] => KOK, Jin Kuan
[researchers_position_2] => Department of Psychology, Universiti Tunku Abdul Rahman, Malaysia
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/Refugee-2.png
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[original_article_reference] =>
[research_footprints] => refugee children; collage life-story elicitation technique (CLET); narrative approach; self-striving
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study reported how refugee children perceived their family lives and coped with life as a refugee in Malaysia. The Collage Life-Story Elicitation Technique (CLET) and a discovery-oriented narrative approach were applied to interview 25 refugee children in Kuala Lumpur. Emotionally, these children felt isolated, lonely, and powerless. To them, a family carried the significance of both vulnerability as well as a source of strength. Besides receiving help from enabling adults and teachers, their coping mechanisms included self-empowerment by being brave and independent. Future studies could explore further insights by engaging these interviewees through focus groups and providing them with better welfare.
[the_background] => Refugees in Malaysia are marginalized and have no legal rights or protection. Furthermore, the majority of the refugee children have no access to education and are vulnerable to behavioral problems, mental health problems, and substance abuse. Meanwhile, research that focuses on the experiences and perceptions and the coping mechanisms of refugee children in Malaysia is rare. Thus, to improve the well-being of refugee children, this study was designed to fill up the existing knowledge gap. The research outcome proves that CLET is a potential eco-systematic approach to act as a key to better understanding the perception and emotion of refugee children in the process of rendering help.
[the_sdg_impact] => Refugee children in Malaysia are often marginalized in society, making them vulnerable and requiring special assistance in meeting their educational needs, mental health care, and socio-emotional well-being. Despite their status, the government should pay attention to their well-being to ensure healthy and inclusive development of the country. By sharing crucial insights about refugee children, this study aligns with UNSDG 3: Good health & well-being.
[article_url] => https://nsuworks.nova.edu/tqr/vol26/iss12/13/
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[doi] => https://doi.org/10.46743/2160-3715/2021.5114
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[publication_title] => Refugee Children in Malaysia: Perceptions of Family and Coping Mechanisms
[journal_title] => The Qualitative Report
[publisher] => Nova Southeastern University Institutional Repository NSUWorks
[year] => December 2021
[subject] => Social Science
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[post_date] => 2022-05-19 13:10:43
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[post_title] => Synthesis of Catalyst from Low-cost Biomass Waste Using 4-BDS Method
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[researchers_name] => LIM, Steven
[researchers_position] => Department of Chemical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[researchers_name_2] => PANG, Yean Ling
[researchers_position_2] => Department of Chemical Engineering, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[research_footprints] => Solid acid catalyst; Biodiesel; Oil palm empty fruit bunch; 4-benzenediazonium sulfonate; Palm fatty acid distillate
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study used biomass from oil palm empty fruit bunch (EFB) to produce a highly efficient solid acid catalyst for biodiesel production. Results proved that the activated carbon (AC) extracted from EFB, when sulfonated by 4-benzenediazonium sulfonate (4-BDS), provided the highest biodiesel yield when calcined at 200 oC. Under optimum esterification conditions of 7 hours and 20 wt.%, the proposed catalyst was able to churn out the highest biodiesel yield, 98.1%. Moreover, synthesizing such highly effective catalyst from low-cost biomass waste is an environmentally friendly solution. Potentially, the proposed technique would lower the production cost of biodiesel and, in the long run, reduce the energy cost in the country.
[the_background] => As fossil fuel reservoirs continue to deplete at an alarming rate, biodiesel is highly sorted after as an alternative energy source. Current biodiesel production is still relatively expensive compared to fossil fuels since existing biodiesel plants largely operate using ineffective catalysis technology with poor yield. To overcome these limitations, this study investigates the synthesis of a biomass-based heterogeneous acid catalyst. Ultimately, such an approach aims to be more cost-effective than the conventional methods and more environmentally friendly.
[the_sdg_impact] => In 2015, the bio-economy sector started to bloom with the production of second-generation biofuels finally achieving commercial scale. Following such progress, developing countries are faced with a new set of market opportunities and policy dilemmas to enhance their usage of biomass, which can be transformed into more valuable products. Coincidentally, in 2015, a set of 17 Sustainable Development Goals were announced by the United Nations addressing pressing issues of society, economy, and environment. The proposed biomass-based heterogeneous acid catalyst promises to expand existing low-efficient catalyst technology for supplying modern and sustainable energy services. At the same time, making the production of biodiesel more affordable with the environmentally friendly catalyst. (SDG 7: Affordable and clean energy)
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0304389419314864
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[doi] => https://doi.org/10.1016/j.jhazmat.2019.121532
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[publication_title] => Biodiesel synthesis from oil palm empty fruit bunch biochar derived heterogeneous solid catalyst using 4-benzenediazonium sulfonate
[journal_title] => Journal of Hazardous Materials
[publisher] => Elsevier
[year] => May 2020
[subject] => Chemical Engineering; Biomass; Biofuel
)
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[post_date] => 2022-05-19 12:39:29
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[post_title] => Highly Accurate New AI-based Cancer Prediction and Classification Framework
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[researchers_name] => SEAH, Choon Sen
[researchers_position] => Faculty of Accountancy & Management, Department of International Business, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[researchers_name_2] => KASIM, Shahreen
[researchers_position_2] => Faculty of Computer Science & Information Technology, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[research_footprints] => Cancer classification; Microarray; Significant directed walk; Gene expression
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study proposed a new computational framework for cancer prediction and classification called Significant Directed Walk (SDW). The framework was developed to refine the search direction and parameters in the existing directed random walk (DRW). This new genetic network allows the algorithm to study the nodes by comparing the gene expression value among the genes. Results showed that the SDW is able to perform better in terms of cancer prediction and classification sensitivity, with its accuracy reaching 95.03%. By adopting this proposed framework, the rate of early cancer detection can be improved significantly, in the long run, increasing the survival rate of the patients.
[the_background] => At present, the cancer prediction and classification tools are less accurate and sensitive and time-consuming as the screening process is not targeted. Moreover, the poor reference data pool limits the ability of the existing directed random walk (DRW) tool. Therefore, there is a demand for an improved DRW framework to identify more cancerous genes with higher accuracy in cancer classification of gene expression data. Hence, this study designs an improved and novel framework to identify the exact genes within the genome that might turn into cancer carriers through the gene expression value.
[the_sdg_impact] => According to WHO, cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020 alone. Early detection is among the most effective way to increase the survival rate of cancer patients. Thus, there is a dire need for technology upgrades and machine learning to shorten the time taken to screen for cancer markers, detection, and classification. This study addresses these needs and, upon implementation, would contribute to the long-term reduction of the premature mortality rate of cancer patients as envisioned in UN SDG 3: Good health and well-being.
[article_url] => https://link.springer.com/article/10.1007/s12652-020-02404-1
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[publication_title] => Significant directed walk framework to increase the accuracy of cancer classification using gene expression data
[journal_title] => Journal of Ambient Intelligence and Humanized Computing
[publisher] => Springer Nature
[year] => August 2020
[subject] => Cancer; Artificial Intelligence (AI)
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[post_title] => Factors Determining the Continuation of Virtual Teaching and Learning
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[researchers_name] => MOSES, Priscilla
[researchers_position] => Department of General Studies, Faculty of Creative Industries, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[researchers_name_2] => YIM, Joanne
[researchers_position_2] => Department of General Studies, Faculty of Creative Industries, Universiti Tunku Abdul Rahman (UTAR), Malaysia
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/05/teaching-2.png
[researchers_profile_2] => https://www.researchgate.net/profile/Joanne-Yim
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[original_article_reference] =>
[research_footprints] => Continuance intention; Psychological ownership; Perceived ease of use; Perceived usefulness; Cloud-based virtual learning environment
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => Theoretically, psychological ownership (PO) is essential to motivate users to adopt technology through their beliefs such as perceived usefulness and perceived ease of use. However, this study showed that the influences on teachers' continued reliance on technology might be more complex than that. Nevertheless, the results indicated that perceived ease of use (PEU) is a stronger reason for teachers to embrace cloud-based virtual learning environments than perceived usefulness (PU) despite teachers having gained experience using it and the platforms being user-friendly. Therefore, the education ministry and school authorities should consider catering to the teachers' readiness and need to encourage the use of cloud-based virtual technology in classrooms and learning widely.
[the_background] => Malaysia invested over 13 years with an estimated cost of RM1.5 billion (about US$500 million). The country is also recognized as one of the pioneers in Asia to initiate a nationwide cloud-based learning environment. However, literature proved that such technology is underutilized despite the strategies and policies designed to drive the adoption. Moreover, most past literature focused on the adoption behavior among students, university educators, or pre-service teachers. Little is known from the perspective of practicing school teachers. Hence, this study examines the factors driving teachers to develop psychological ownership towards a cloud-based virtual learning environment and their intention to continue. The outcome intends to understand the underutilization of such technology in education for developing countries facing similar challenges.
[the_sdg_impact] => Education is among one of the significantly affected sectors amidst this COVID-19 pandemic. Teaching and learning experiences had to instantly adopt and adapt to virtual learning environment leaving students and teachers to struggle, especially in developing and under-developed countries. Apart from the readiness in terms of infrastructure, the willingness of teachers to utilize these facilities and continue using them even after physical classes resume needs to be understood. Therefore, the insights provided by this study would benefit policymakers and school authorities to re-evaluate teachers' training needs to embrace a virtual learning environment to provide the best 21st century learning experience for students. (SDG 4: Quality education)
[article_url] => https://link.springer.com/article/10.1007/s11423-019-09661-8
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[doi] => https://doi.org/10.1007/s11423-019-09661-8
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[publication_title] => Predicting teachers’ continuance in a virtual learning environment with psychological ownership and the TAM: a perspective from Malaysia
[journal_title] => Educational Technology Research and Development
[publisher] => Springer Nature
[year] => April 2019
[subject] => General Studies; Virtual Learning
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[post_date] => 2022-05-19 12:13:24
[post_date_gmt] => 2022-05-19 04:13:24
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[post_title] => Oil Palm Waste-derived Nano-photocatalyst Can Treat Wastewater from Textile Industry
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[researchers_name] => NG, Law Yong
[researchers_position] => Department of Chemical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Oil.png
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[research_footprints] => Agricultural waste; Carbon quantum dot; Hydrothermal; Photocatalytic degradation; Organic dye
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S2214714420306930-ga1.jpg
[figures] =>
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[the_novelty] => Lignin extracted from empty fruit bunches (EFB) can undergo hydrothermal treatment with urea to produce a stable photocatalyst that degrades dye molecules. The study used this technique to develop photocatalysts, nitrogen-doped carbon quantum dots (NCQDs), to treat water sources polluted with harmful organic dyes. By including NCQDs, 97%-98% of methylene blue and malachite green dyes were degraded within 120-180 minutes of sunlight exposure compared to only 59% of degradation without the catalyst. Furthermore, findings also showed that the number of cycles to repeatedly used photocatalyst could go up to 15 cycles with approximately 70% decolorization efficiency. In conclusion, the proposed NCQDs are not just effective water treatment substances but are also a greener option to reduce oil palm waste.
[the_background] => Synthetic organic dyes used in textile industries are major sources of water pollution. Dyes such as methylene blue and malachite green are highly toxic and harmful for marine life and humans. Moreover, the presence of dye molecules in the water stream may prevent sunlight penetration into the water, affecting the photosynthesis of aquatic plants. Therefore, a stable and reliable catalyst is required to treat the wastewater before discharging. Separately, empty fruit bunch (EFB) are oil palm waste that is largely discarded. The rich molecular make-up of this waste has a huge potential to be converted into carbon-based nanoparticles and catalysts. Thus, this study proposed nano-photocatalyst derived from biomass as a safe solution to decolorize the dye molecules in the water streams.
[the_sdg_impact] => A 2020 article published by CNN highlighted devastating environmental and health effects caused by textile dyeing practices of the global fashion industry. Nations like Bangladesh, highly dependent on the garment sector as their source of income, face severe pollution threats as the industry’s wastewater largely gets dumped directly into their rivers and streams. Therefore, this study is useful to substantially reduce such water pollution threats and minimize their adverse impacts on human health and the environment through an environmentally sound management technique. (SDG 12: Responsible consumption and production)
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S2214714420306930?via%3Dihub
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[doi] => https://doi.org/10.1016/j.jwpe.2020.101816
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[publication_title] => Sustainable production of nitrogen-doped carbon quantum dots for photocatalytic degradation of methylene blue and malachite green
[journal_title] => Journal of Water Process Engineering
[publisher] => Elsevier
[year] => April 2021
[subject] => Chemical Engineering; Water Process Engineering
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[post_date] => 2022-05-19 11:48:58
[post_date_gmt] => 2022-05-19 03:48:58
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[post_title] => Hypertension Patients on Medication Should Avoid Consuming Green Tea Excessively
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[researchers_name] => LEE, Siew Keah
[researchers_position] => Faculty of Medicine and Health Sciences, Department of Pre-clinical sciences, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[research_footprints] => EGCG; Catechin; Green Tea; Nadolol; Herb-drug interaction; Hypertension
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/1-s2.0-S0944711321001665-ga1_lrg.jpg
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[the_novelty] => This study provides evidence of the counter-effect of a common botanical product when consumed by hypertension patients on medication. One of the major catechins found in green tea extract is known as epigallocatechin gallate (EGCG). Due to the established blood pressure lowering effects of green tea, it is not surprising that hypertension patients might consume highly concentrated or purified EGCG along with their medication with or without their physicians’ knowledge. However, based on a 14-day observation of continuous consumption of herbal supplement with EGCG content as low as 10 mg/kg b.w. showed that EGCG interfered with the effectiveness of nadolol, an antihypertensive drug commonly prescribed to hypertensive patients. Such reduced drug effect results from RNA expression dysregulation of the key nadolol transporters (Oatp 1a5, Oct1and P-gp). Thus, proving an unfavorable herb-drug interaction and outcome among the hypertension patients prescribed nadolol. Essentially, these insights are useful for physicians to advise their patients, adjust nadolol prescription dosage, or prescribe alternative drugs for green tea consumers with hypertension.
[the_background] => Statistics showed that less than 13% of hypertensive patients achieved blood pressure control (<140/90 mm Hg) while on treatment. Such a scenario results in physicians either prescribing more medication or increasing the dosage. In the long run, these actions would potentially contribute to medication and economic burden as well as increase the risk of drug side effects among the consumers. Meanwhile, herbal or ‘natural’ medicine has been gaining popularity among patients with various ailments. Particularly, green tea consumption is highly favored due to its extensive therapeutic effects. Although one of its medicinal properties is to lower blood pressure, its effect on hypertension patients on antihypertension medication is unclear. Therefore, this study investigates the effects of a widely available herbal supplement, EGCG, on the blood pressure of those given nadolol and the biological mechanisms involved.
[the_sdg_impact] => According to WHO, close to 1.3 billion adults aged 30-79 years worldwide have hypertension, and it is a major cause of premature death. Adopting a healthy lifestyle is among the most recommended hypertension management techniques, while many patients trust herbs or ‘natural’ medicine to do the trick. Therefore, it is crucial for physicians and healthcare personnel to advise patients on medication to monitor the supplements or herbs that are not prescribed yet being consumed. In extension, such effort would improve the drug effectiveness among hypertension patients on medication and, in extension, reduce premature mortality of hypertension-related cardiovascular diseases (SDG 3: Good health and well-being).
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0944711321001665
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[doi] => https://doi.org/10.1016/j.phymed.2021.153623
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[publication_title] => Oral epigallocatechin gallate reduces intestinal nadolol absorption via modulation of Oatp1a5 and Oct1 transcriptional levels in spontaneously hypertensive rats
[journal_title] => Phytomedicine
[publisher] => Elsevier
[year] => September 2021
[subject] => Medicine and Health Sciences; Pre-clinical sciences
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[post_date] => 2022-05-19 11:32:01
[post_date_gmt] => 2022-05-19 03:32:01
[post_content] =>
[post_title] => Non-destructive Test for Quick Concrete Strength Test
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[researchers_name] => LEE, Foo Wei
[researchers_position] => Department of Civil Engineering (DCI), Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[research_footprints] => compressive strength; non-destructive test (NDT); elastic wave; air-entrained rubberized concrete
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/05/crystals-10-00912-ag-550.webp
[figures] =>
[video] =>
[the_novelty] => This study suggested adopting the non-destructive test (NDT) as a more effective method to assess concrete strength during the hardening process. Among the significant improvement observed by adopting this testing method is the amount of time needed. Results indicate that the test is able to reduce the time taken to 1 day, as compared to the conventional process, which requires 28 days. Moreover, this approach is also resource-efficient as it does not involve the specimen being demolished during testing. Last but not least, the findings proved that wave amplitude and velocity are crucial to determining the compressive strength development of air-entrained rubberized concrete.
[the_background] => In recent years, there has been a steadily increasing demand for rubberized concrete due to its lightweight, strength, elasticity, ductility, and energy and force absorption potentials. Air-entraining agents have been introduced in rubberized concrete to further lengthen its lifespan and durability. However, there has been inconsistency in terms of the compressive strength of air-entrained rubberized concrete compared to conventional concrete. The test required to determine the compressive strength and properties is known to be tedious and time-consuming. Therefore, this study proposes a more efficient and reliable assessment of rubberized concrete specimens, particularly in completed buildings.
[the_sdg_impact] => Over the years, green construction has been receiving more attention. Concrete production is slowly being altered to be greener through the use of scrap tires to produce rubberized concrete. To ensure the shift to an environmentally sound material does not compromise the safety and durability of the buildings constructed, a reliable testing method is necessary. Hence, the findings of this study would serve as a reference to enhance and upgrade the technological capabilities of the construction industry. (SDG 9: Industry, innovation and infrastructure)
[article_url] => https://www.mdpi.com/2073-4352/10/10/912
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/concrete-2.jpg
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[doi] => https://doi.org/10.3390/cryst10100912
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[publication_title] => Compressive Strength Forecasting of Air-Entrained Rubberized Concrete during the Hardening Process Utilizing Elastic Wave Method
[journal_title] => Crystals
[publisher] => MDPI
[year] => October 2020
[subject] => Civil Engineering;
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[post_date] => 2022-05-19 11:20:47
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[post_title] => Smartphone App Smart Enough to Detect Skin Cancer
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[post_name] => smartphone-app-smart-enough-to-detect-skin-cancer
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[researchers_name] => HUM, Yan Chai
[researchers_position] => Department of Mechatronics and Biomedical Engineering (DMBE), Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/05/Smartphone.png
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[research_footprints] => Melanoma; Skin cancer screening; Skin lesion detection; Multimedia-based healthcare systems; ;Smartphone app; ;Teledermatology; Deep learning; ISIC skin lesions dataset
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => The study proposed using deep learning technology to design a highly accurate skin cancer diagnosis tool in the form of a smartphone app. In order to optimize the functions of the app, a thorough analysis was performed using different computational intelligence models on various models of smartphones, screen resolutions, and android versions. As a whole, the proposed technology is set to design a cheap, user-friendly, and reliable smartphone camera-based app capable of eliminating the need for sophisticated external sensor tools. Through such an app, the chances of early skin cancer detection can be improved, and physicians' inconsistent manual diagnosis could be avoided.
[the_background] => One of the most effective ways to battle cancer is through early detection. At present, early detection of skin cancer is highly reliant on experts such as doctors and dermatologists. However, past literature has proven that the conventional method such as manual inspection using ABCDE criteria has various limitations, namely subjectivity and inaccuracy, owing to the varying experience level of dermatologists and irregular characteristics of malignant skin lesions. Thus, leading to the condition being missed or misdiagnosed. Therefore, this study aims to replace the current skin cancer early detection method with object detection and deep learning technology by integrating the ABCDE criteria. Since smartphones or smart devices have seamlessly been integrated into our daily routine, this study proposes the development of a smartphone app as a potential early diagnostic tool.
[the_sdg_impact] => According to the World Health Organisation (WHO), there has been a significant rise in the cases of malignant skin cancer over the past decade. Early detection of skin cancer is required to classify symptoms so that attending dermatologists and clinicians can recommend effective disease control measures. Presently, the computational capability of smart handheld devices is feasible to be integrated with object detection technology. As a result, the coupling of smartphones and deep learning could aid in detecting and classifying skin lesions. A handy diagnostic tool with such capability would increase the chances of early detection, thus improving the survival rates of the patients by having the disease treated sooner. (SDG 3: Good health and well-being)
[article_url] => https://link.springer.com/article/10.1007/s11042-021-11013-9
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[publication_title] => The development of skin lesion detection application in smart handheld devices using deep neural networks
[journal_title] => Multimedia Tools and Applications
[publisher] => Springer Nature
[year] => May 2021
[subject] => Mechatronics and Biomedical Engineering
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[post_date] => 2022-05-19 11:09:08
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[post_title] => Psychological Factors Could Trigger Obesity among Adults
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[researchers_name] => FOO, Chai Nien
[researchers_position] => Department of Population Medicine, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[research_footprints] => obesity; risk factors; psychological; adults; Malaysia
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study provided evidence of potential psychological determinants that cause obesity among men and women. Consistent with past literature, the results proved that women are more likely to be obese than men. More specifically, married, middle-aged Indian women with only school-level education face a higher risk of being obese. Among the contributing psychological factors in women for such an outcome is the stressful life events encountered and their quality of life. On the other hand, men facing perceived stress or having suicidal ideation have higher chances of being obese. To the authors’ knowledge, this study provides primary evidence of the association between psychological determinants and adult obesity. Potentially, policymakers could use the findings as a reference to address psychological needs when designing effective obesity prevention strategies in the community.
[the_background] => Obesity has been commonly linked to the risk of developing various major illnesses and psychological effects. However, the understanding of how psychological factors could lead to obesity remains unclear. In Malaysia, obesity prevalence among adults has shown a four-fold increase between 1996 and 2015. Being highly populated with working adults, the high incidence rate of obesity in Selangor is concerning as compared to other states. Therefore, this study aims to understand the underlying factors and psychological determinants causing adults of Selangor to be obese or overweight.
[the_sdg_impact] => According to Global Burden of Disease 2019, a high body mass index is among the top risk factors contributing to the development of non-communicable diseases (NCDs). In the global status report on NCDs, WHO recorded 39% of adults to be overweight, and the prevalence is expected to rise by 2025. In the Malaysian context, it recorded the highest obesity rate in adults compared to other Southeast Asian countries. Therefore, the findings of this study would benefit policymakers and healthcare personnel to understand the socio-demographic variables and psychological factors leading to poor health conditions among Malaysians. Such insights would contribute to effective prevention and treatment strategies when managing obesity-linked NCDs (SDG: Good health and well-being).
[article_url] => https://www.mdpi.com/1660-4601/18/3/868
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/05/obesity3.jpg
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[publication_title] => Prevalence, Associated Factors and Psychological Determinants of Obesity among Adults in Selangor, Malaysia
[journal_title] => International Journal of Environmental Research and Public Health
[publisher] => MDPI
[year] => January 2021
[subject] => Medicine, Health Science
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[post_date] => 2022-05-19 10:57:29
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[post_title] => Organic Liquid-based Air Pressure Sensor with Dual Functions
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[researchers_name] => CHEE, Pei Song
[researchers_position] => Department of Mechatronics and Biomedical Engineering (DMBE), Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[researchers_name_2] => LIM, Eng Hock
[researchers_position_2] => Department of Electrical and Electronic Engineering, Universiti Tunku Abdul Rahman (UTAR), Malaysia
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[research_footprints] => Electrical and electronic engineering; Fluids; Polymers
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => Unlike existing sensors that are limited to only detecting air pressure, this study designed a novel structure that combines the antenna and pressure sensing functionalities into a single piece. The proposed liquid dielectric resonator antenna (LDRA) can achieve high compactness as it uses an organic solvent, acetonitrintrile, with a low loss tangent at 2.4 GHz. Findings indicate that the antenna gain of the design is at least 2 dB higher than that of the commonly suggested water LDRA. Additionally, the soft-lithography technique used allows rapid prototyping. In short, this proposed design promises a dual-sensing functionality with improved sensitivity and circuit footprint. It also reduces material costs and can potentially be expanded into wearable devices that require higher power consumption.
[the_background] => Pressure sensors are essential for monitoring and controlling, particularly in biomedical technologies and auto industries. One of the limitations of presently available commercial sensors is the restricted mobility as they require wires and batteries to operate. Moreover, the existing rigid containers also limit the functions of the antenna structure as a pressure sensor. Hence, requiring a more flexible and stretchable material to improve the storage of electrical energy that can respond to the change of stimuli. As a solution, this study proposed a wireless power technology that combines both wireless receivers and sensors as an alternative.
[the_sdg_impact] => Pressure sensors play a huge role in the medical and healthcare sectors, especially among ventilator and respiratory manufacturers. Over the decade, there has been a noticeable need for flexible pressure sensors, preferably low-cost, portable, and light-weighted. Besides, the 9th UN SDG, Industry, Innovation and Infrastructure, also encourages the development of quality, reliable, sustainable, and resilient infrastructure to support the evolving community and technological needs. Hence, in alignment with such goals, the materials and design of the liquid dielectric resonator antenna (LDRA) proposed promises to improve the air pressure sensing capability by overcoming the limitations of existing models.
[article_url] => https://www.nature.com/articles/s41598-020-72021-7
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[doi] => https://doi.org/10.1038/s41598-020-72021-7
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[publication_title] => Compact organic liquid dielectric resonator antenna for air pressure sensing using soft material
[journal_title] => Scientific Reports
[publisher] => Springer Nature
[year] => September 2020
[subject] => Electrical and Electronic Engineering
)
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[post_date] => 2022-04-14 11:06:33
[post_date_gmt] => 2022-04-14 03:06:33
[post_content] =>
[post_title] => Superheavy Nuclei 119 − 122 Synthesis in Fusion-Evaporation Reactions
[post_excerpt] =>
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[researchers_name] => FENG, Zhaoqing
[researchers_position] => School of Physics, South China University of Technology, China
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[original_article_reference] =>
[research_footprints] => Dinuclear system model; Fusion-evaporation reactions; Superheavy nuclei; Cross sections
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/04/NST_Article-19_V3_EN-scaled.jpg
[figures] =>
[video] =>
[the_novelty] => While attempting to produce superheavy nuclei (SHN) with Z = 119 – 122 in the fusion-evaporation reactions within the dinuclear system (DNS) model, this study discovered that 44Sc+252Es was the optimal combination in the 3n channel with a cross-section of 3 pb. Maximum cross-sections of the evaporation residues (ER) were found in the (2-5)n evaporation channels, i.e., approximately 1 pb in the 3n evaporation channel. The results were in good agreement with the experimental data from Dubna. The SHN were produced by bombarding the actinide nuclides with the transition elements from Period 4. Since the orientations were the main determining factor of the ER cross-sections, all possible collision orientations were included by applying the Monte Carlo approach in the nucleon transfer process. Using these results as a reference, future investigations should be conducted to uncover other potentially promising reaction mechanisms to produce SHN.
[the_background] => SHN (Z ≥ 106) are given rise by the strong binding shell effect when the Coulomb repulsion is overcome. The initial synthesis of SHN nearly half a decade ago involved multinucleon transfer reactions in collisions of two actinide nuclei. Meanwhile, the formation dynamics of SHN in massive fusion and multinucleon transfer reactions have been the main focus. Hence, systematic studies on the production of SHN are needed to predict the reaction mechanism, including optimal projectile-target combinations. This study conducted a comprehensive study on the fusion dynamics of the formation of superheavy nuclei within the DNS model by adopting the Monte Carlo approach. The findings shed some light on the fusion-evaporation reactions applied for synthesizing SHN with Z = 119 – 122, bringing SHN research one step closer to discovering “island of stability.”
[the_sdg_impact] => Superheavy elements (SHE) are rare naturally and only exist briefly under highly controlled circumstances. Their common applications include smoke detectors (americium), neutron radiography and neutron interrogation (curium and californium), and nuclear weapons (plutonium). Thus, besides exploring the concept of “magic numbers” and “island of stability,” a better understanding of the formation mechanism of SHE could lead to a significant advancement of nuclear technology. By focusing on the synthesis of various SHN via fusion-evaporations reactions, the output of this in-depth study contributed to the progress of SHN synthesis. Therefore, it fulfilled UNSDG9: Industry, Innovation & Infrastructure.
[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00946-3
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[publication_title] => Systematics on production of superheavy nuclei Z=119−122 in fusion-evaporation reactions
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => September 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_date] => 2022-03-22 11:44:32
[post_date_gmt] => 2022-03-22 03:44:32
[post_content] =>
[post_title] => Exploration of Short-Lived Nuclei Using Newly Commissioned Collinear Laser Spectroscopy
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[researchers_name] => BAI, Shiwei (白世伟)
[researchers_position] => School of Physics, State Key Laboratory of Nuclear Physics & Technology, Peking University, China
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[researchers_name_2] => YANG, Xiaofei (杨晓菲)
[researchers_position_2] => School of Physics, State Key Laboratory of Nuclear Physics & Technology, Peking University, China
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2022/03/Commissioning-2.png
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[original_article_reference] =>
[research_footprints] => Nuclear properties; Collinear laser spectroscopy; Laser-ablation ion source; Photon detection; Isotope shift
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/03/2022_NST_Article_02_v2_EN-scaled.jpg
[figures] =>
[video] =>
[the_novelty] => As an initial step to fully leverage the available radioactive ion beam facilities and resources, this study developed a collinear laser spectroscopy (CLS) apparatus combined with an offline laser ablation ion source at Peking University. The CLS was commissioned using a bunched stable calcium ion beam being accelerated up to 20 keV, with a pulse width of approximately 10 µs. This CLS, integrated with the ion source and an anti-collinear laser system, has enabled high-resolution measurements of the hyperfine structure spectra of stable 40,42,44,48Ca isotopes. With its successful commissioning, the CLS is ready for laser spectroscopy measurement of unstable nuclei at radioactive ion beam (RIB) facilities in China, paving the way for further developing higher-sensitivity collinear resonance ionization spectroscopy techniques.
[the_background] => The fundamental properties of atomic nuclei, such as nuclear spins, magnetic dipole moments, electric quadrupole moments, and mean-squared charge radii, are the essential experimental observables in studying the exotic nuclear structure and nucleon-nucleon interactions. Despite having various experimental methods to measure these nuclear properties, CLS is one of the most sophisticated experimental techniques available to simultaneously measure these properties in a nuclear-model independent way. This is realized by probing the subtle hyperfine effects, only as small as one part in a million compared with the total atomic transition frequency, resulting from the interaction between the atomic nucleus and surrounding electrons. CLS system has been set up in various RIB facilities worldwide to explore the exotic structure of radioactive isotopes. Lanzhou's HIRFL-RIBLL and Beijing's BRIF are among the uprising RIB facilities with short-lived isotopes ready for in-depth nuclear structure studies. The CLS, however, has not yet been involved in nuclear physics research at the domestic RIB facilities so far. The CLS apparatus developed by this study thus represents new opportunities for advanced studies of the nuclear properties of unstable nuclei at the RIB facilities in China.
[the_sdg_impact] => The unexpected new phenomena of unstable nuclei have been continuously unveiled when the study reaches the exotic isotopes far from the beta-stability line. By exploring short-lived nuclei produced artificially at RIB facilities, this study helps scientists understand the rich, complex, and even unexplored exotic structure of atomic nuclei and the nucleon-nucleon interactions. Ultimately, this would unveil the puzzle: where and how heavy matter forms in the universe (UNSDG 9: Industry, Innovation & Infrastructure).
[article_url] => https://link.springer.com/article/10.1007/s41365-022-00992-5
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[publication_title] => Commissioning of a high-resolution collinear laser spectroscopy apparatus with a laser ablation ion source
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => January 2022
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_date] => 2022-03-13 12:52:32
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[post_content] =>
[post_title] => Mature Software for 3D Bunch Position & Charge Measurement
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[researchers_name] => XU, Xingyi Xu (许兴懿)
[researchers_position] => Beam Instrument and Control Department, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, China
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/03/HOTCAP.png
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[researchers_name_2] => LENG, Yongbin Leng (冷用斌Y)
[researchers_position_2] => Beam Instrument and Control Department, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, China
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[research_footprints] => Bunch-by-bunch measurement; HOTCAP software package; Data analysis; High-speed oscilloscope
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/03/2022_NST_Article_01_v2_EN-scaled.jpg
[figures] =>
[video] =>
[the_novelty] => This study developed HOTCAP, a free, user-friendly, and interactive software, for simultaneous measurement of 3D bunch-by-bunch position and charge from the waveform of a high-speed oscilloscope. Being able to operate on Windows 10, HOTCAP could also output injection transient analysis, bunch response function reconstruction, and turn-by-turn beam analysis. Its visual interface was developed based on PyQT5. HOTCAP was coded using Python on the backend, and its architecture comprised the user interface (UI) module, the calculation module, and the input-output (IO) module. Future studies shall improve the algorithm to eliminate HOTCAP’s current need for a constant bunch length.
[the_background] => Bunch-by-bunch measurement includes transverse position measurements, longitudinal phase measurements, charge measurements, beam size measurements, and emittance. Among these, position measurement is the most important and common technique carried out via the random phase sampling method using a digital oscilloscope. However, since a large amount of input data and complex digital signal processing are involved, there is a high demand for comprehensive data processing algorithms or corresponding data processing software packages to be used in high-speed oscilloscope-based 3D bunch charge and position measurements. In order to fulfill the need, researchers from Shanghai Synchrotron Radiation Facility (SSRF) Beam Instrument Group have successfully developed HOTCAP (a visualization software package) to serve as an online measurement system that can simultaneously measure the bunch-by-bunch 3D position and strip the refilled charge signal. Other accelerators will benefit from this software as soon as the researchers share the source code in the near future.
[the_sdg_impact] => SSRF strives to uphold its potential and reputation as a world-class state-of-the-art beam facility. To help achieve that, this research developed the first mature and free software package for high-speed oscilloscope-based three-dimensional (3D) bunch charge and position measurement. The output contributes to the advancement of beam diagnosis technology, which enhances the operation of synchrotron radiation facilities, realizing UNSDG 9: Industry, Innovation & Infrastructure.
[article_url] => https://link.springer.com/article/10.1007/s41365-021-00966-z?utm_source=xmol&utm_medium=affiliate&utm_content=meta&utm_campaign=DDCN_1_GL01_metadata
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[publication_title] => HOTCAP: a new software package for high-speed oscilloscope-based three-dimensional bunch charge and position measurement
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => November 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_date] => 2022-03-13 12:31:17
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[post_title] => Enhanced GRID Mission Nanosatellite Gamma-Ray Detector
[post_excerpt] =>
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[post_name] => enhanced-grid-mission-nanosatellite-gamma-ray-detector
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[researchers_name] => WEN, Jiaxing (温家星 )
[researchers_position] => Engineering Physics, Tsinghua University, China
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[researchers_name_2] => ZENG, Ming (曾鸣)
[researchers_position_2] => Engineering Physics, Tsinghua University, China
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[original_article_reference] =>
[research_footprints] => Gamma-ray bursts; Scintillation detectors; SiPM; CubeSat
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/03/56.jpg
[figures] =>
[video] =>
[the_novelty] => This research revealed the in-depth design (both hardware and firmware) of the first and second compact nanosatellite gamma-ray detectors built for the Gamma-Ray Integrated Detectors (GRID) mission. The detector comprised four Gd2Al2Ga3O12 : Ce (GAGG:Ce) scintillators coupled with four silicon photomultiplier (SiPM) arrays, and the detector’s gamma-ray detection efficiency ranged between 10 keV and 2 MeV. The first and second detectors were launched into Sun-synchronous orbits with an altitude and inclination of 500 km 97.5 ° and 97.3 °, on October 29, 2018, and November 6, 2020, respectively. The detectors managed to accumulate data for more than 300 hours of on-orbit observation. For further context, detailed calibration of the detector using both simulations and experiments will be reported elsewhere in the near future.
[the_background] => The GRID mission is a project which bears the main objective to involve students in monitoring the transient gamma-ray sky in the local universe and in accumulating a sample of gamma-ray bursts (GRBs) associated with gravitational waves (GWs). The first detector was launched into a Sun-synchronous orbit on October 29, 2018. After the on-orbit functional and performance tests of the first detector, fewer hardware modifications and improvements have been made in the second detector. This paper shows the detailed design of the GRID detector, and the functionality and performance of this design have been verified by two launches. By sharing these significant details of the compact CubeSat gamma-ray detector, this study encourages and attracts students from multi-disciplinary to participate in GRID so as to grow their hands-on experience in astrophysics.
[the_sdg_impact] => Astrophysics is a subject area that often involves multi-disciplinary collaboration in developing hardware and data. Hence, having a well-developed research facility and infrastructure is essential to let students and researchers deploy their output in a real environment. Besides sharing the detailed hardware and firmware design, this study also motivates students to participate in the GRID mission by describing how the latter empowered the study's progress. Therefore, the outcome of this study aligns well with UNSDG 9: Industry, Innovation & Infrastructure by supporting the development of research and technology.
[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00937-4
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[publication_title] => Compact CubeSat Gamma-ray detector for GRID mission
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => September 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_date] => 2022-03-09 14:42:04
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[post_title] => New Multifunctional Carbon Nanosheet Construction Strategy
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[researchers_name] => WU, Dingcai
[researchers_position] => School of Chemistry, Sun Yat-sen University, China
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[research_footprints] => Carbon nanosheets; Multifunctional templates; Hierarchical pores; Heteroatom doping
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/03/2022_CPP_Article_01_v2_EN-scaled.jpg
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[the_novelty] => This study explores a range of construction mechanisms with different conditions to improve present 2D material performance. As a breakthrough, a new strategy to construct Fe,N-codoped hierarchical porous carbon nanosheets (Fe-N-HP-CNS) by using 2D Fe-Zn layered double hydroxides (Fe-Zn-LDH) was developed. The proposed multifunctional templating strategy simplifies the synthetic route and yields well-defined 2D carbon nanosheets with a hierarchical porous structure and a functional carbon framework. Overall, the novel method promises an improved template functionality while eliminating the adverse effects and limitations of single-functioned conventional carbon nanosheet construction techniques.
[the_background] => 2D porous carbon nanosheets have desirable physical and chemical properties, including excellent electrical conductivity, superior chemical stability, and adjustable carbon framework. Hence, the materials have been widely used in electrochemical energy storage, catalysis, battery, water treatment, and many more. With that said, existing carbon nanosheet templates largely fit a single function. Moreover, the preparation processes are not only costly and complex, but also non-environmentally friendly. Therefore, this study looks into the synthesis process of carbon nanosheets by leveraging the 2D structure and potential multifunctional characteristics.
[the_sdg_impact] => 2D porous carbon nanosheets have become the recent most in-demand porous carbon due to the uniqueness of its structure and promising functionalities, potentially useful in various applications. Given the increasing requirements on applications in our current lifestyle, there’s a growing need for a simple and precise construction strategy of this ‘super’ material. Therefore, the novel approach developed in this study expands the functionality of 2D porous carbon nanosheets by improving resource-use efficiency and adopting a cleaner and greener construction mechanism (SDG 9: Industry, Innovation and Infrastructure).
[article_url] => https://link.springer.com/article/10.1007/s10118-022-2656-x
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[publication_title] => Multifunctional Templating Strategy for Fabrication of Fe, N-Codoped Hierarchical Porous Carbon Nanosheets
[journal_title] => Chinese Journal of Polymer Science
[publisher] => Springer Nature
[year] => November 2021
[subject] => Chemistry, Polymer Science
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[post_date] => 2022-02-26 11:06:40
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[post_title] => New Variance Reduction Method for Higher Accuracy Monte Carlo (MC) Reactor Criticality Calculation
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[researchers_name] => PAN, Qingquan (潘清泉)
[researchers_position] => School of Nuclear Science and Engineering, Shanghai Jiao Tong University, China
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[researchers_name_2] => LIU, Xiaojing (刘晓晶)
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[research_footprints] => RMC code; Global homogenization; Variance reduction; SPN theory
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/12/Screenshot-2022-02-26-105443-1.png
[figures] =>
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[the_novelty] => This study developed an SP3-coupled global variance reduction (GVR) method, which brought the efficiency and accuracy of the Monte Carlo (MC) criticality calculation to a whole new level. The workflow of the SPN-based GVR involved MC global homogenization in determining global cross-sections, SP3 equation-solving to obtain the global flux distribution, and global weight windows approximation. Despite achieving a noteworthy milestone, this research aimed to enhance the GVR’s performance in the near future by involving rigorous SPN theory and an adjoint method for the SPN theory.
[the_background] => The design and performance of a reactor rely significantly on the reactor criticality calculation, which applies the MC method most of the time. Besides enhancing the overall efficiency and accuracy, variance reduction (VR) methods are crucial in maintaining the numerical stability of MC multi-physics simulations. The VR methods developed in the past (i.e. UFS, UTD, UVM) face limitations in terms of working principles, techniques, and validation. To fulfill the demand for a more superior reactor, this study proposed an SP3-coupled GVR that enhanced the overall precision of MC criticality calculation. This development could potentially improve the reactor shielding calculations, leading to a higher-performance reactor.
[the_sdg_impact] => A nuclear reactor is built and operated based on sophisticated technology. To cope with the higher demand on its performance, various aspects such as design and safety features need to be enhanced. The GVR method proposed in this study showed great potential in pushing the limits of reactors in the future. Therefore, its achievement materialized UNSDG 9: Industry, Innovation & Infrastructure, by creating a milestone in the nuclear reactor design.
[article_url] => https://link.springer.com/article/10.1007/s41365-021-00973-0
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[publication_title] => SP3-coupled global variance reduction method based on RMC code
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => November 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_date] => 2022-02-26 10:57:26
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[post_title] => Nuclear Mass Refinement by Machine Learning
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[researchers_name] => GAO, Zepeng
[researchers_position] => College of Physics Science and Technology, Shenyang Normal University, China
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[researchers_name_2] => WANG, Yongjia
[researchers_position_2] => School of Science, Huzhou University, China
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[research_footprints] => Nuclear mass; Machine learning; Binding energy; Separation energy
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/12/Screenshot-2022-02-26-105340.png
[figures] =>
[video] =>
[the_novelty] => Is there any room to increase the accuracy of theoretical nuclear mass prediction? This study demonstrated that Light Gradient Boosting Machine (LightGBM) is a highly competent tool for improving the accuracy of theoretical nuclear mass and binding energy predicted. With respect to experimental binding energy, LightGBM’s refinement managed to reduce the root mean square deviations (RMSDs) by approximately 90%, 65%, 40%, and 60% in the liquid-drop model (LDM), Duflo–Zucker (DZ) mass model, Weizsäcker–Skyrme (WS4) model, and finite-range droplet model (FRDM) respectively. Consistent RMSD improvement was obtained compared to the 66 newly measured nuclei that appeared in the new atomic mass evaluation, AME2020. Besides that, the LightGBM-refined mass models also yielded single and two-neutron separation energies values that matched those derived experimentally. All it took for the LightGBM to work was the input of characteristic quantities like mass and proton numbers. Relevance analysis of input characteristic quantities for each mass model was carried out using SHapley additive exPlanations (SHAP) and valuable results were obtained for future improvement and development of various nuclear mass models.
[the_background] => Nuclear mass has been a crucial and challenging subject, especially for nuclei near the drip lines (i.e., the boundaries delimiting the zone beyond atomic nuclei decay). A Bayesian neural network (BNN) refinement is a promising approach for theoretical models to deduce nuclear mass with higher accuracy. On the other hand, a tree-based learning algorithm developed by Microsoft in 2016, known as LightGBM, shows upsides, including better learning capability, greater efficiency, and better accuracy. This puts LightGBM in an advantageous position to be applied in studies of nuclear mass. As an effort to verify the potentials of the LightGBM machine learning algorithm, this study deployed LightGBM in predicting the masses and binding energy of unknown nuclei. The reduced RMSDs obtained were an excellent validation of LightGBM’s value in nuclear mass studies, which could set a more refined direction for future research.
[the_sdg_impact] => The advancement of astrophysics and nuclear physics correlates with the level of knowledge in nuclear mass. Hence, a highly efficient machine learning method is needed to speculate the masses of unknown nuclides, especially superheavy and neutron-rich nuclides. This study validated LightGBM’s potential in nuclear mass studies and, consequently, indicated the importance of machine learning in the progress of astrophysics and nuclear physics. These fundamental findings are essential to facilitate future scientific research by leveraging the ever-evolving technological capability, which aligns with the visions of UNSDG 9: Innovation, industry, and infrastructure.
[article_url] => https://link.springer.com/article/10.1007/s41365-021-00956-1
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[publication_title] => Machine learning the nuclear mass
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => October 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_date] => 2022-02-22 14:44:25
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[post_title] => Voltage Profiling for Solar Photovoltaic (PV) System in Varying Weather Conditions
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[researchers_name] => MOHD AZMAN, Mohd Arif bin
[researchers_position] => Centre for Research and Innovation Management, Universiti Teknikal Malaysia Melaka (UTeM), Malaysia
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[research_footprints] => Renewable energy; solar photovoltaic; voltage profile intermittency; solar output fluctuation; voltage rise.
[graphic_abstract] =>
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[the_novelty] => The distribution system of the power grid is affected by the high voltage fluctuation due to the solar PV systems. A grid-connected battery energy storage system is a potential solution. The study analyzed solar PV system voltage profiles and solar power output with four different module technologies at various locations in the free-standing installation method. The study concluded that voltage fluctuation is the highest during the day in both low and high load conditions. Future studies should evaluate the effects of weather and position of solar PV systems against the system’s voltage profile.
[the_background] => As more and more people adopt a greener lifestyle, the demand for solar panel reliance has increased in recent years. However, in the usage of solar panel-derived energy, voltage supply seems to fluctuate due to irregular sunlight availability. Such condition poses a negative effect on the power grid, especially the distribution network. Therefore, this study aims to quantify the voltage fluctuation for small-scale solar photovoltaic systems under different loading conditions, specifically voltage and solar power output. The potential solution for this would be a grid-connected battery energy storage system, which allows grid quality and reliability maintenance.
[the_sdg_impact] => The increasing adoption of solar power encourages the shift from the current system that uses fossil fuel, promoting cheaper and cleaner energy production. This study strongly associates with Goal 7: Affordable and Clean Energy and Goal 12: Responsible Consumption and Production of the UN’s Sustainable Development Goals (SDG) as the findings are useful for the relevant parties to take suitable actions in improving existing solar PV systems. Ultimately, serving as a good reference for institutions and countries intending to move towards sustainable energy and reduce their environmental impacts through solar power.
[article_url] => https://www.ijrer.org/ijrer/index.php/ijrer/article/view/10450/pdf
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[publication_title] => Quantification of Voltage Profiles Intermittency for Small-Scale Solar Photovoltaic System under Different Loading Conditions
[journal_title] => International Journal of Renewable Energy Research-IJRER
[publisher] => IJRER
[year] => March 2020
[subject] => Engineering
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[post_title] => Response Surface Methodology (RSM) for Better Quality Synthetic Rubber
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[researchers_name] => MAHAMOOD, Mazlin Aida binti
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[the_novelty] => This study uses statistical and mathematical models to optimize cure characteristics of Natural Rubber/ EPDM (a type of synthetic rubber) blends. The proposed software identified the optimum mixing parameters (temperature, rotor speed, time) for adding maleic anhydride grafted EPM (MAH-g-EPM). As a result, the miscibility, and physical and rheological properties of the NR/EPDM blend were significantly improved. Thus, creating a more stable rubber blend by increasing the material resistance towards deformation. Such software and analytical technique enable future material characterization to be conducted efficiently across multiple parameters within a short period of time.
[the_background] => The blending of two or more elastomers (polymers with elastic properties) is common to obtain new materials with improved and superior properties compared to its original phases at a minimal cost. Applying a similar concept, rubber blends are frequently tested and created to produce newer and sturdier materials for various uses. Natural rubber/EPDM blends are by far the most prominent form of synthetic rubber in terms of performance and elasticity. However, the synthetic rubber blends have shown several mechanical property degradations due to poor compatibility. This study aims to provide suitable and effective cure characteristics of NR/EPDM blends for better miscibility and compatibility.
[the_sdg_impact] => Rubber is still widely used in automobile manufacturing along with many other industries for various purposes. According to a March 2021 BBC article, there still is a growing demand for rubber worldwide while there is a shortage in terms of supply. With lands being scarce to accommodate the expansion of rubber plantation, alternative methods are required to make up for the demand. As the use of synthetic rubber increasing, there is a need to constantly improve its quality and durability under minimum expenditure and production time. Thus, the findings of this study clearly promote the enhancement of scientific research to upgrade material production through a more sustainable and efficient use of resources (SDG 9: Industry, innovation and infrastructure).
[article_url] => https://www.scientific.net/AMM.761.441
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[doi] => https://doi.org/10.4028/www.scientific.net/AMM.761.441
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[publication_title] => Cure Characteristics of Natural Rubber/EPDM Blends for the Effect of MAH Grafted EPM and Compounding Parameters via Response Surface Methodology
[journal_title] => Applied Mechanics and Materials
[publisher] => Scientific.net
[year] => May 2015
[subject] => Engineering
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[post_title] => Using Coffee Waste Film in Pulsed Laser Generation
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[researchers_name] => LATIFF, Anas Abdul
[researchers_position] => Faculty of Electronic & Computer Engineering, Universiti Teknikal Malaysia Melaka (UTeM), Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2022/02/coffee.png
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[research_footprints] => Q-switching operation; Ytterbium-doped fiber; Erbium-doped fiber; Thulium-doped fiber; Fiber laser; Saturable absorber; Spent coffee ground
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2022/02/Generation-of-Q-switched-fiber-laser-at-1.0-1.55-and-2.0-µm-employing-a-spent-coffee-ground-based-saturable-absorber.png
[figures] =>
[video] =>
[the_novelty] => This study demonstrated for the first time a spent coffee ground (SCG) film made of waste product from coffee beans as saturable absorber (SA) for wideband pulsed laser generations. The findings indicate that the fabricated SCG film modulator has a modulation depth, saturable intensity, and non-saturable absorption of 30%, 150 MW/cm2, and 28%, respectively. The fabricated SCG film modulator produced a highest pulse energy of 0.152 μJ and shortest pulse of 4.20 μs at the 1-μm region, which fits the expectations of pulsed laser performance. The SCG film modulator's ability to induce pulsed lasers at various regions, alongside its considerably simple fabrication process, may benefit diverse photonic applications.
[the_background] => Pulsed lasers have high pulse energy, with a pulse width that can be tuned up from a microsecond to hundreds of nanoseconds. The active method generation of pulsed lasers in the past is less desirable due to the size, cost, and handling challenges. Hence, passive techniques using modulators have been explored, and nanomaterials like graphene (a form of carbon) are highly preferred in producing such modulators. This study demonstrates the use of waste products from coffee grounds as bio-resources for carbon to synthesize graphene nanomaterials suitable for modulators.
[the_sdg_impact] => Global coffee production creates more than 23 million tons of waste per year. Coffee waste is an inexpensive and green alternative for nanomaterials production, which could be applied across various fields. As the pioneering study to utilize waste coffee grounds as bioresources to synthesize graphene nanomaterial for laser technology, it is a great example of enhancing and promoting environmentally sustainable material production with increased resource-use efficiency. Therefore, the study objectives align well with UN Sustainable Development Goal (SDG) 9, Industry, innovation and infrastructure.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S1068520020304247?via%3Dihub
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[doi] => https://doi.org/10.1016/j.yofte.2020.102434
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[publication_title] => Generation of Q-switched fiber laser at 1.0-, 1.55- and 2.0-µm employing a spent coffee ground based saturable absorber
[journal_title] => Optical Fiber Technology
[publisher] => Elsevier
[year] => January 2021
[subject] => Engineering
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[post_date] => 2022-01-18 11:45:18
[post_date_gmt] => 2022-01-18 03:45:18
[post_content] =>
[post_title] => High Precision Pre-surgical Intervention Using Newly Improved Epileptogenic Zone Identification Technique in Patients
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[researchers_name] => PENG, Syu-Jyun (彭徐鈞 )
[researchers_position] => esearch Center for Artificial Intelligence in Medicine, Taipei Medical University, Taiwan
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[original_article_reference] =>
[research_footprints] => Temporal lobe epilepsy; drug resistant; stereoelectroencephalography; SEEG; brain connectivity; topology; complex partial seizures; graph theory
[graphic_abstract] =>
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[video] =>
[the_novelty] => In the past decade, the usage of stereoelectroencephalography (SEEG) to identify the epileptogenic zone in patients with drug-resistant epilepsy has increased. In this study, researchers used high-frequency oscillations (HFO) in SEEG to distinguish the common changes in the epileptic brain over the course of a seizure. The implementation involved the usage of 3D electrodes implant based on the SEEG methodology. As a result, the onset, propagation, and termination of seizure were identified by observing the high frequency brain waves. The overall change in wave frequency gives a complete map of HFO. Essentially, this HFO map could serve as a biomarker and improve surgical strategy to control/correct seizures with better accuracy and precision. Hence, these new insights would be useful references for researchers and physicians to advance existing epilepsy treatment outcomes.
[the_background] => To improve surgical outcomes, it is common to do a non-invasive evaluation prior to surgery to locate the epileptogenic zone (EZ). However, if the EZ is not readily identified, invasive electroencephalography is required. Therefore, it opens the possibility to produce biased data due to a lack of experience. In this study, researchers explore the usage of stereoelectroencephalography (SEEG) to identify ictal high-frequency oscillation (HFO) networks. The primary aim of the study is to develop a new approach for surgery or neuromodulation that may help physicians improve treatment modalities for epilepsy, including resection, cortical stimulation, and neuromodulations treatment that are responsive to network topologies.
[the_sdg_impact] => According to a 2019 report from the World Health Organization (WHO), an estimated 50 million people worldwide suffer from epilepsy, making it one of the most common neurological diseases globally. As presented in this study, it is notable that using high-frequency oscillations (HFO) in stereoelectroencephalography (SEEG) can identify the epileptogenic zone (EZ) in the brain. Resection of the areas of the brain where HFOs have been recorded gives a good postsurgical outcome. Thus, the finding of this study would help towards the realization of UNSDG 3: Good Health and Well-Being, which aims to ensure healthy lives and promote well-being for all ages, as well as UNSDG 9: Industry, Innovation and Infrastructure, for its application of research outcome to accelerate A.I.-based medical technology advancement.
[article_url] => https://thejns.org/view/journals/j-neurosurg/131/4/article-p1086.xml
[main_image] => https://iesresearch.solutions/wp-content/uploads/2022/01/epileptogenic-3.jpg
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[doi] => https://doi.org/10.3171/2018.6.JNS172844
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[publication_title] => Ictal networks of temporal lobe epilepsy: views from high-frequency oscillations in stereoelectroencephalography
[journal_title] => Journal of Neurosurgery
[publisher] => JNS
[year] => Nov 2018
[subject] => Medical; Artificial Intelligence
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[ID] => 31036
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[post_date] => 2021-12-30 11:29:21
[post_date_gmt] => 2021-12-30 03:29:21
[post_content] =>
[post_title] => Promising Method to Improve Characterization of Heavy Elements using Back-n Neutron Beamline
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[researchers_name] => HU, Xinrong
[researchers_position] => Shanghai Institute of Applied Physics, SLEGS, China
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[researchers_name_2] => WANG, Hongwei
[researchers_position_2] => Shanghai Advanced Research Institute, SLEGS, China
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST-16-2.png
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[original_article_reference] =>
[research_footprints] => Cross section; 197Au(n, γ); Back-n; C6D6; Pulse height weighting technology
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST_Article-16_V7.jpg
[figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/C6D6-.png
[video] =>
[the_novelty] => This study verified the effectiveness of the upgraded CSNS Back-n neutron beamline detection system for neutron capture cross-section measurements using gold (197Au (n, γ)). The new setup included C6D6 detectors and Li-Si flux monitor, the pulse height weighting technique (PHWT) detection technology was used to analysis the data. The results proved that the 197Au (n, γ) reaction cross section measured with neutron energies ranging from 1 eV to 100 keV is consistent with the latest standard evaluations data. Meanwhile, the findings indicated a promising less than 2% statistical uncertainty for the 197Au (n, γ) reaction cross section measured. Therefore, it is evident that the CSNS Back-n neutron beamline facility enhancement proposed in this study would benefit future characterization and the study of synthesis of heavy elements.
[the_background] => Neutron-induced reactions have long been used to characterize and synthesize heavy elements. Such techniques have been inspired by the naturally occurring slow neutron capture process (s process) in stars. At present, most neutron capture cross section measurements only one capture criterion for the 197Au (n, γ) reaction with 2.5 MeV thermal neutron energy. Hence, this study proposed integrating C6D6 detectors and PHWT detection technology with the CSNS Back-n neutron beamline. The overall feasibility of the experimental setup was determined by cross-referencing the data with the standard neutron capture cross-section database.
[the_sdg_impact] => Neutrons have long played an essential role in engineering materials for nuclear reactors, along with material characterization. As the demand for electric energy grows, so does the demand for potential alternative energy production sources, one of which is nuclear power. Thus, there is a constant need to advance and enhance existing nuclear detection and imaging technology (UN SDG 9: Industry, innovation and infrastructure). The findings of this study could serve as a reference to improve the performance of the current Back-n neutron beamline facility for better heavy chemical elements characterization and data analysis.
[article_url] => https://link.springer.com/article/10.1007/s41365-021-00931-w
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[doi] => https://doi.org/10.1007/s41365-021-00931-w
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[publication_title] => Measurements of the 197Au(n, γ) cross section up to 100 keV at the CSNS Back-n facility
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => September 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_author] => 154
[post_date] => 2021-12-06 11:41:32
[post_date_gmt] => 2021-12-06 03:41:32
[post_content] =>
[post_title] => Optimization of EAST Performance via Tungsten Control
[post_excerpt] =>
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[researchers_name] => XU, Zong
[researchers_position] => College of Physics and Optoelectronic Engineering, Shenzhen University, China
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/15-01.png
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[researchers_name_2] => ZHANG, Ling
[researchers_position_2] => Division of Plasma Diagnostics, Institute of Plasma Physics, Chinese Academy Science, China
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[original_article_reference] =>
[research_footprints] => Tungsten accumulation; Counter-NBI; Favorable B t; ELMy H-mode; EAST
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST_Article-15.jpg
[figures] => https://iesresearch.solutions/wp-content/uploads/2021/11/Tungsten-.png
[video] =>
[the_novelty] => Via experimental investigation on the Experimental Advanced Superconducting Tokamak (EAST), this study reported how the behavior of tungsten (in ELMy H-mode plasmas) could be controlled by neutral beam injection (NBI) and toroidal field (Bt). The concentration of tungsten in the plasma operation was successfully lowered by applying counter-NBI and favorable Bt. It’s crucial to prevent tungsten accumulation and keep tungsten concentration below 10–4 to avoid degradation of plasma confinement and periodic H–L transitions. Future in-depth studies could be carried out to better understand the implications of increased turbulent transport (during the co/counter-NBI phases) on the suppression of tungsten accumulation.
[the_background] => Despite being preferred for plasma-facing materials in fusion devices, tungsten tends to accumulate in EAST type-I ELMy H-mode plasmas. Among the adverse outcomes caused by such accumulation include disruption, loss of radiation, and degradation of energy confinement. Meanwhile, literature indicates that tungsten accumulation could be suppressed by controlling the neoclassical transport, inward pinch of high-Z impurities (PHZ), and radial electric field (Er). Furthermore, these three variables were associated with NBI. Thus, this study focused on the potential of NBI in manipulating tungsten behavior in the core of an EAST type-I ELMy H-mode plasma, a mode that led to strong impurity accumulation in EAST. By mastering the technique to avoid tungsten accumulation, the EAST will be able to perform more optimally.
[the_sdg_impact] => As the first Tokamak with superconducting toroidal and poloidal magnets, the EAST is valuable for nuclear fusion and plasma research. Thus, its performance stability and consistency are a top priority. By exploring effective methods to minimize tungsten accumulation in the EAST, this research showcased efforts that aligned with the targets of UNSDG 9: Industry, Innovation & Infrastructure.
[article_url] => https://link.springer.com/article/10.1007/s41365-021-00929-4
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[doi] => https://doi.org/10.1007/s41365-021-00929-4
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[publication_title] => Tungsten control in type-I ELMy H-mode plasmas on EAST
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => September 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_date] => 2021-12-02 09:46:36
[post_date_gmt] => 2021-12-02 01:46:36
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[post_title] => Successful Designing of Candidate Lattice of SSRF-U Reaching the Soft X-ray Diffraction Limit
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[researchers_name] => LIU, Xinzhong
[researchers_position] => Accelerator Physics and Technology Department, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/beam-.png
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[research_footprints] => Diffraction-Limited Storage Ring (DLSR); Shanghai Synchrotron Radiation Facility Upgrade (SSRF-U); Intra-Beam Scattering (IBS); Touschek scattering; Beam lifetime
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/NST_Article-14_V1-1.jpg
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[the_novelty] => In this study, we design a new lattice of the Shanghai Synchrotron Radiation Facility upgrade (SSRF-U), a low-emittance photon source designed with an emittance of 53.2 pm·rad (N-IBS), using 20 seven-bend achromat cells. This small emittance and high electron density will inevitably lead to non-negligible intra-beam scattering (IBS) and Touschek scattering. Therefore, to weaken the effect of IBS and Touschek scattering, emittance growth and beam lifetime in the SSRF-U storage ring were studied by particle simulation within a series of different machine configurations. After considering almost all the methods, the best configuration was obtained, contributing to the upgrade plan of the SSRF storage ring. The method proposed in this paper would serve as an important reference for transforming other light sources or designing and constructing new light sources.
[the_background] => The high-performance SSRF has contributed to significant scientific findings related to various research fields, including biomedicine, material science, environmental science, physics, and chemistry. Meanwhile, there is an increasing demand for synchrotron light sources with reduced beam emittance approaching or reaching X-ray diffraction limits. However, the properties (e.g., beam lifetime and brightness) of such light sources are bound to be degraded by IBS and Touschek scattering. While designing a new lattice of the storage ring, reaching soft-X ray diffraction limit, to upgrade the SSRF, this study has also run extensive simulations to overcome the adverse effects of IBS and Touschek scattering. By identifying the optimal parameters for yielding a beam with lower emittance and higher brightness. The SSRF-U would become one of the state-of-the-art research assets to facilitate scientists making exceptional scientific contributions.
[the_sdg_impact] => The SSRF is well-known as a necessary light source facility that contributes to multiple subjects of studies. Despite that, continuous upgrading and improving SSRF are essential to enhance its beam properties and performance to keep up with the rapid pace of scientific research. The candidate lattice of the storage ring for SSRF-U, reaching soft-X ray diffraction limit and Intra-beam scattering optimization, contribute to the upgrade plan of the SSRF storage ring. Hence, this study is well-aligned with the targets of UNSDG 9: Industries, Innovation & Infrastructure.
[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00913-y
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[publication_title] => Intra-beam scattering and beam lifetime in a candidate lattice of the soft X-ray diffraction-limited storage ring for the upgraded SSRF
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[publisher] => Springer Nature
[year] => August 2021
[subject] => Engineering; Nuclear Physics; Applied Physics
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[post_title] => New Immunotherapy Strategy Shows Promising Results in Treating Various Solid Tumors
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[researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan
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[researchers_name_2] => CHIU, Shao-Chih (邱紹智)
[researchers_position_2] => Center for Cell Therapy, China Medical University Hospital, Taiwan
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[the_novelty] => This study proposed a novel immunotherapy strategy to treat various solid tumors more effectively and safely. The proposed chimeric antigen receptor (CAR)-T therapy using natural killer (NK) cells, when used to target tumor-associated antigen (TAA), caused lesser damage to healthy tissues. The neoexpressed TAA of interest is known as human leukocyte antigen G (HLA-G). Results indicated that by targeting HLA-G, the proposed CAR-NK successfully triggers the cytotoxic killing response of the immune system when it recognizes the tumor cells. Moreover, the efficacy of the treatment is seen to increase when the tumors are pre-exposed to low-dose chemotherapy. Overall, the study showed promising results under laboratory conditions. However, further studies are suggested to validate the combined effects of chemotherapy and HLA-G CAR-NK cells and expand the application in clinical settings.
[the_background] => Among the greatest challenges when treating solid tumors is the immunosuppressive tumor microenvironment (TME), leading to low and ineffective immune responses. Although past attempts using CAR-T to target these immunosuppressive TME showed positive results, severe damages to non-tumor cells have been reported. Moreover, monotherapy of CAR through the conventional techniques have also presented limitation, thus, suggesting a need to explore combined therapies to increase the antitumor capability of the treatment. This study aims to improve the antitumor efficacy of CAR-T treatment strategy by identifying an accurate target and exploring potential combined strategy by understanding the synergistic mechanisms involved.
[the_sdg_impact] => In recent years, precision medicine has become a highly sort after area of cancer research. The concept primarily revolves around targeted care through individualized treatment approaches. One such treatment is immunotherapy, sometimes known as biological therapy, which uses the body’s natural defense mechanism to fight cancer. According to a statistic shared by John Hopkins, to date, approximately 15-20% of patients have achieved long-lasting results with the treatment. With most existing treatments still being in the trial phase or displaying a certain amount of limitation, clearly, there is room for further improvement. This study, therefore, could potentially serve as a significant breakthrough in the field by increasing cancer cell target precision and treatment efficacy. Such outcome also aligns with the visions of UN SDG 3: Good health and well-being in reducing the mortality rate of non-communicable diseases, like cancer, through prevention and treatment.
[article_url] => https://jitc.bmj.com/content/9/10/e003050.info
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[publication_title] => Targeting human leukocyte antigen G with chimeric antigen receptors of natural killer cells convert immunosuppression to ablate solid tumors
[journal_title] => Journal of Immunotherapy of Cancer
[publisher] => BMJ
[year] => October 2021
[subject] => Medical; Cancer; Immunotherapy
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[post_date] => 2021-11-26 11:03:05
[post_date_gmt] => 2021-11-26 03:03:05
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[post_title] => Reprogramming DNA Replication Mechanism to Stop Cancer Spreading
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[researchers_name] => WANG, Shao-Chun (王紹椿)
[researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan
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[research_footprints] => PCNA; pY211 PCNA; ssDNA; cGAS; innate immune response; type I interferon
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/DNA-5.jpg
[figures] =>
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[the_novelty] => This study proved that disrupting tyrosine-211 phosphorylation of proliferating cell nuclear antigen (pY211-PCNA) is crucial to stopping the spread of breast cancer. By blocking the phosphorylation of the key DNA replication coordinator (PCNA), the replication mechanism collapses. Thus, a series of inflammatory responses outside the tumor cell is triggered. Such immune response is mediated by natural killer (NK) cells which then signal the stop of tumor from spreading any further. These findings provided valuable insights on the previously unclear tumor-promoting signaling pathway. Potentially, such understanding would benefit the development of effective anti-cancer immunotherapy strategies.
[the_background] => Cancer cells have a strong replication stress-coping capability, enabling them to divide and grow uncontrollably compared to normal cells. Such characteristic is a result of the ability of these cancer cells to promote DNA damages repair. With that said, much of the underlying signaling mechanisms are still poorly understood. Therefore, this study aims to investigate the mechanisms involved in the regulation of DNA replication within breast cancer cells and understand the impacts on tumor progression.
[the_sdg_impact] => According to the statistics provided by WHO, an estimated 2.3 million women were diagnosed with breast cancer, with close to 700 000 deaths reported globally in 2020 alone. Existing treatment often consists of a combination of surgical removal, radiation therapy, and medication to prevent further spreading of the tumor. Hence, to reduce the mortality rate among women with breast cancer, research should explore effective tumor biomarkers and target pathways. By providing significant insights on how cell proliferation mechanisms can be reprogrammed to inhibit tumor growth, this study serves as a good reference in developing future immunotherapy.
[article_url] => https://www.sciencedirect.com/science/article/pii/S2211124721009712
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[doi] => https://doi.org/10.1016/j.celrep.2021.109537
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[publication_title] => Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA
[journal_title] => Cell Reports
[publisher] => Elsevier
[year] => August 2021
[subject] => Medical; Biomedical Science
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[post_date] => 2021-11-25 23:57:01
[post_date_gmt] => 2021-11-25 15:57:01
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[post_title] => Addition of Diabetic Drug Increases Lung Cancer Treatment Effectiveness
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[researchers_name] => HUANG, Wei-Chien (黃偉謙)
[researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/Smoking-2.png
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[research_footprints] => Cancer metabolism; Non-small-cell lung cancer; Predictive markers
[graphic_abstract] =>
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[video] =>
[the_novelty] => This study proved that non-small cell lung cancer (NSCLC) patients who smoke are less likely to respond to existing epidermal growth factor receptors tyrosine kinase inhibitor (EGFR TKI) treatment. The findings suggested that by including metformin, a drug for diabetes mellitus, the enzymatic activation of liver kinase B1 – AMP-activated protein kinase (LKB1-AMPK) will produce better response to EGFR TKI and clinical outcomes. This is primarily due to the effectiveness of the combination in improving treatment sensitivity and reducing tumor growth, as shown in both in vitro and in vivo attempts for patients with wild-type LKB1. Thus, confirming the proposed addition of AMPK activator metformin can overcome the treatment resistance experienced by a majority of wild-type EGFR NSCLC patients who smoke. Essentially, such insights are useful to design new therapeutic strategies for NSCLC patients who are least receptive to existing treatments.
[the_background] => The EGFR is among the key targets when treating NSCLC. Hence, EGFR TKI has been widely used as part of the initial treatment strategies. However, the clinical outcomes tend to vary in terms of effectiveness for NSCLC patients with wild-type EGFR. Increasingly, reports have associated smoking consequences with the development of lung cancer and the reduction of EGFR TKI treatment responsiveness in NSCLC patients. Therefore, this study aims to understand the EGFR TKI resistance mechanisms in NSCLC patients who smoke. The findings would potentially be used to explore an effective treatment strategy against NSCLC, especially for patients with wild-type EGFR.
[the_sdg_impact] => Approximately 80% to 85% of lung cancers are recognized as non-small cell lung cancer (NSCLC). According to the National Cancer Institute of the U.S., smoking cigarettes, pipes, or cigars are major risk factors leading to the development of the disease. By identifying the biological mechanisms that associate cigarette extracts with NSCLC treatment resistance, this study expands the possibility of increasing the effectiveness of the existing treatment. Ultimately, the proposed combination of metformin with EGFR TKI would serve as a new therapeutic strategy to promote treatment response and reduce the mortality rate of patients with NSCLC. (SDG 3: Good health and well-being)
[article_url] => https://www.nature.com/articles/s41388-020-01597-1
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/Smoking-4.jpg
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[publication_title] => Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC
[journal_title] => Oncogene
[publisher] => Springer Nature
[year] => December 2020
[subject] => Medical; Lung Cancer
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[post_author] => 154
[post_date] => 2021-11-25 21:29:52
[post_date_gmt] => 2021-11-25 13:29:52
[post_content] =>
[post_title] => Deciphering a New Bacterial Cyclic AMP–AMP–GMP Synthetase
[post_excerpt] =>
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[post_name] => deciphering-a-new-bacterial-cyclic-amp-amp-gmp-synthetase
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[researchers_name] => CHEN, Yeh (陳曄)
[researchers_position] => Institute of New Drug Development, China Medical University, Taiwan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/Enzyme.png
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[video] =>
[the_novelty] => This in-situ study reported the crystal structure of EcCdnD, a CD-NTase from Enterobacter cloacae that produces cyclic AMP-AMP-GMP in apo and substrate-bound forms. Besides having two ATP binding sites, its overall structure was different from that of other CD-NTase. Furthermore, the relationships between its structure and activities were discussed in detail. Findings showed that EcCdnD is active when it binds to ATP or a combination of ATP and GTP. Moreover, Mg2+ is the cofactor that contributes the most to the activity of EcCdnD. Based on the results, a catalytic pathway for the CTN-producing EcCdnD is proposed. Further research is needed to confirm the exact catalytic pathway.
[the_background] => Cyclic nucleotides are intracellular second messengers that regulate cell function by controlling the activity of protein kinases. Some cyclic dinucleotides (CDNs), which play crucial roles in the immune system, are synthesized by mammalian cyclic GMP-AMP synthase (cGAS) and its homolog dinucleotide cyclase in Vibrio cholerae (VcDncV). Among the recently discovered cGAS/DncV-like nucleotidyltransferases (CD-NTases), only two cyclic-trinucleotides (CTN)-producing Type I CD-NTases had undergone analysis of crystal structure. Therefore, this study was conducted to complement the knowledge gap by determining the structure and activity of EcCdnD in apo-form and when bounded to various substrates and mutants. Along with the possible catalytic mechanisms that produce CTNs, the output of this research serves as a robust reference for future studies of CTN-producing CD-NTases.
[the_sdg_impact] => Cyclic nucleotide signaling is an essential cellular central relay system that translates primary signals (e.g., hormonal stimuli or changes in the cellular environment) to a cellular response. Since the structure of bacterial CD-NTases is similar to that of mammalian cGAS and oligoadenylate synthetase (OAS), a better understanding of the former’s properties and catalytic pathway would help advance biomedical sciences. In extension, the biochemical and biophysical studies of EcCdnD in this research potentially contribute to the realization of UNSDG 3: Good Health & Well-Being by expanding the knowledge base of cyclic nucleotides.
[article_url] => https://academic.oup.com/nar/article/49/8/4725/6219115
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[publication_title] => Crystal structure and functional implication of a bacterial cyclic AMP–AMP–GMP synthetase
[journal_title] => Nucleic Acids Research
[publisher] => Oxford University Press
[year] => May 2021
[subject] => Medical; Drug Development
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[post_date] => 2021-11-25 20:46:57
[post_date_gmt] => 2021-11-25 12:46:57
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[post_title] => New Advanced Tool for Efficient Study of Lipid Characteristics
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[the_novelty] => Is there an efficient way to simplify the workflows of lipidomic analysis and studies of lipid characteristics? This research develops the first web-based platform, LipidSig, which allows users to conduct in-depth and comprehensive lipidomic analysis efficiently. Users can upload up to four tables of different analysis sections. Based on the data uploaded, LipidSig can carry out five functions (i.e. Profiling, Differential Expression, Correlation, Network, and Machine Learning) to analyze lipidomic change thoroughly. In addition, LipidSig has a unique feature that enables the conversion between lipid species and characteristics according to a user-defined characteristics table. As a web-based tool, there is great potential for LipidSig to be improved and optimized continuously to meet the needs of users.
[the_background] => Different from general metabolites, lipids could exert distinct biological functions not only as an individual but also as a group defined by a variety of lipid characteristics (e.g., lipid classes, shapes, double bonds, chain lengths, and hydroxyl groups). To date, one of the bottlenecks faced by lipidomic studies is the lack of analysis tools to efficiently analyze both lipid species and lipid characteristics. Despite the readiness of several tools for analysis of lipid characteristics, some of them impose strict formatting requirements on lipid names, while some can hardly conduct characteristics analyses beyond lipid class, chain length, and double bonds. Hence, this study develops the first web-based tool, LipidSig, which shows high efficiency and flexibility in analyzing streamlined data mining of lipidomic datasets. Being a completely free tool with advanced features, LipidSig provides researchers in lipidomics to further develop and enhance their research.
[the_sdg_impact] => Lipids play multiple crucial roles ranging from storing energy to forming signaling molecules. Thus, a comprehensive knowledge base for the diversity and composition of lipids will contribute to more significant discoveries of lipids’ biological functions. The potential of LipidSig in the development of lipidomics has been proven by its features to bridge the existing gaps in the lipid-specific analysis. With that, this study serves as an epitome to enhance physiological and pathological research as well as encourage further scientific discoveries as envisioned in UNSDG9: Industry, Innovation & Infrastructure.
[article_url] => https://academic.oup.com/nar/article/49/W1/W336/6287848
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[publication_title] => LipidSig: a web-based tool for lipidomic data analysis
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[publisher] => Oxford University Press
[year] => May 2021
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[post_title] => Can COVID-19 Infection Cause Autoimmune and Inflammatory Diseases?
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[researchers_position] => College of Medicine, China Medical University, Taiwan
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[research_footprints] => autoimmune disease; rheumatic disease; COVID-19; SARS-CoV-2; treatment
[graphic_abstract] =>
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[the_novelty] => Why is the battle against COVID-19 far from over? The coronavirus (SARS-CoV-2) is known to have a complex array of messenger RNA (mRNA) and share molecular similarities with human proteins. Thus, upon infection, extreme autoimmune and inflammatory reactions could be triggered. Based on a systematic review of existing case reports, this study summarized a list of potential triggers of autoimmune and rheumatic diseases following the COVID-19 infection. Among the rare but significant incidences associated are autoimmune cytopenia, cutaneous vasculitis, encephalitis, and Guillain-Barre syndrome. However, it should be noted that most of the literature analyzed was of short-term case reports or case series. For a more definitive conclusion, the study suggests future research to consider establishing a long-term follow-up mechanism.
[the_background] => At present, the only available method to defend ourselves from COVID-19 is through vaccination. However, there are rising concerns and hesitancy among vaccine recipients due to its potential to trigger autoimmune and rheumatic complications. Moreover, the rapidly piling up literature makes it even harder for information seekers to acquire reliable and recent resources. Therefore, this study aimed to compile existing evidence from peer-reviewed sources such as PubMed and EMBASE to verify and produce a list of autoimmune and rheumatic diseases potentially associated with COVID-19 infection. Such a thorough overview would benefit vaccine developers in terms of vaccine design and post-marketing surveillance.
[the_sdg_impact] => While the UN’s 3rd SDG, Good health and well-being, focused on increasing life expectancy and reducing mortality rates of some common diseases, more efforts are required to manage a wide range of other existing and emerging health issues. The 2020 COVID-19 pandemic has caused a global health crisis where the preparedness of healthcare systems of developed and under-developed nations is equally challenged to manage a threat of such scale. Hence, this study would serve as a good reference for healthcare authorities when handling the global immunization efforts against COVID-19.
[article_url] => https://www.frontiersin.org/articles/10.3389/fimmu.2021.645013/full
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/COVID2.jpg
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[doi] => https://doi.org/10.3389/fimmu.2021.645013
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[publication_title] => Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review
[journal_title] => Frontiers in Immunology
[publisher] => Frontiers
[year] => March 2020
[subject] => Medical; Covid-19
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[post_date] => 2021-11-25 19:51:29
[post_date_gmt] => 2021-11-25 11:51:29
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[post_title] => Inhalation of Heavy Metals Lead to Asthma Development in Children
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[researchers_name] => HWANG, Bing-Fang (黃彬芳)
[researchers_position] => College of Public Health, China Medical University, Taiwan
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[research_footprints] => Heavy metals; asthma; birth cohort; vulnerable time windows; coexposure
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/11/asthma.jpg
[figures] =>
[video] =>
[the_novelty] => This study provided evidence that combined exposure to heavy metals (Pb with As, Cd, and Hg) during pregnancy and infancy periods could cause children to develop asthma in later stages. The findings primarily focused on understanding the effects of such exposure on the lung development mechanism and to recognize the sensitive time windows which lead to the risk of asthma development in children. Contrary to most occupational exposure to high levels of heavy metal exposure, even low levels of these components when inhaled during and post-pregnancy by the mother and infant could trigger the disease. The specific sensitive time windows identified are during gestational weeks 1 to 14 and 21 to 40, and 1 to 3 weeks after birth. These results serve as a warning to pregnant women and mothers to avoid getting themselves and their newborns exposed to serious outdoor air pollution.
[the_background] => Asthma is a common allergic respiratory disease among children and adults. Much of the causes of this disease are either genetic or environmental. Past studies have linked exposure to air pollution with numerous respiratory diseases development. However, most of these studies evaluate the effects of high levels of heavy metals exposure under working environment. To date, there are limited evidence on the effects of low-level exposures of such poor air quality on children with asthma. Therefore, this study focused on assessing the effects of inhaling traces of heavy metals during and post-pregnancy to determine accurate sensitive time windows.
[the_sdg_impact] => Globally, more than 300 million people suffer from asthma. According to the World Health Organization (WHO), the number of patients with asthma is expected to increase by 100 million by 2025. On the other hand, it is undeniable that the air quality has deteriorated over the years due to pollution and high levels of fine particulate matter in the air continue to impose greater health concerns. Thus, the study findings are essential for pregnant women and new mothers to take necessary precaution to avoid exposure to serious air pollution. Moreover, healthcare practitioners could use the findings are a reference to advise the groups at risk to take appropriate measures to ensure the healthy development of their children (SDG 3: Good health and well-being).
[article_url] => https://www.jacionline.org/article/S0091-6749(20)32424-6/ppt
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[doi] => https://doi.org/10.1016/j.jaci.2020.12.634
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[publication_title] => Combined exposure to heavy metals in PM2.5 and pediatric asthma
[journal_title] => Asthma and Lower Airway Disease
[publisher] => American Academy of Allergy, Asthma & Immunology
[year] => December 2020
[subject] => Medical; Asthma
)
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[post_date] => 2021-11-25 19:26:45
[post_date_gmt] => 2021-11-25 11:26:45
[post_content] =>
[post_title] => High Pre-surgery Blood Sugar Levels Can Extend Patient Hospitalization Period
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[researchers_name] => KUO, Chin-Chi (郭錦輯)
[researchers_position] => College of Medicine, China Medical University, Taiwan
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[the_novelty] => This research evaluated the risk of prolonged hospital stay as a result of high blood sugar levels recorded before non-critical surgeries regardless of patient diabetic status. A large retrospective cohort study was conducted by analyzing patients' medical records of appendectomy and laparoscopic cholecystectomy at China Medical University Hospital (CMUH), Taiwan, between 2003 and 2016. The findings proved that patients with higher preoperative blood glucose (POBG) level undergoing these standard procedures are more likely to have an extended hospitalization than those with lower POBG levels. To be precise, appendectomy patients with POBG levels of ≥123 mg/dL are 19% more likely to stay beyond 3 days in the hospital, while laparoscopic cholecystectomy patients with POBG levels of ≥128 mg/dL had a 17% higher risk. Thus, it was concluded that the optimal POBG level with reduced risks might be lower than the current standards for common surgeries. Such insight could improve existing clinical practice guidelines for patients undergoing surgery to ensure an effective recovery experience.
[the_background] => There is an ongoing debate on whether routine blood sugar levels before surgery are necessary for healthy or asymptomatic adults. To date, there are no fixed guidelines available for such assessment, especially for those undergoing elective non-critical surgical procedures. However, increasing evidence has shown that high preoperative blood sugar levels do harm surgical patients. Hence, this research aimed to assess the effect of POBG level on hospital length of stay in patients undergoing appendectomy or laparoscopic cholecystectomy, both of which are highly standardized and regulated non-critical procedures. The findings would serve as a potential basis for exploring the role of POBG levels in determining factors affecting patient recovery.
[the_sdg_impact] => The Lancet Commission on Global Surgery (LCoGS) 2030 report, supported by WHO, aims to strengthen global surgical ecosystems, especially by focusing on the integration of emergency and essential surgical care within universal health coverage (UHC) plans (Global Surgery 2030). From a broader perspective, these efforts are directed to enable economic growth, UHC, and the achievement of UN SDGs. When looked at closely, the findings of this research could potentially play an important role in improving under-addressed surgical issues and providing quality healthcare services for patients (SDG 3: Good health and well-being).
[article_url] => https://care.diabetesjournals.org/content/44/1/107
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/blood-2.jpg
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[doi] => https://doi.org/10.2337/dc19-0963
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[publication_title] => Association Between Preoperative Blood Glucose Level and Hospital Length of Stay for Patients Undergoing Appendectomy or Laparoscopic Cholecystectomy
[journal_title] => Diabetes Care
[publisher] => American Diabetes Association
[year] => October 2020
[subject] => Medical; Diabetes
)
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[post_author] => 154
[post_date] => 2021-11-25 18:33:52
[post_date_gmt] => 2021-11-25 10:33:52
[post_content] =>
[post_title] => Characterization of Initial Key Steps of IL-17 Receptor B Oncogenic Signaling for Targeted Therapy of Pancreatic Cancer
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[researchers_name] => LEE, Wen-Hwa (李文華)
[researchers_position] => Drug Development Center, China Medical University, Taiwan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/pancreatic-.png
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[researchers_name_2] => WU, Heng-Hsiung (吳恒祥)
[researchers_position_2] => Drug Development Center, China Medical University, Taiwan
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/11/pancreatic-2.png
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[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study includes different proteomics, genomics, and imaging experiments conducted on in-vitro (cellular) and in-vivo (animal) models. The findings established the role of interleukin 17 receptor B (IL-17RB) in tumorigenesis and metastasis of pancreatic cancer via a distinct pathway. It revealed that the phosphorylation of tyrosine-447 (Y447) is highy important for IL-17 induced signaling IL-17RB, which associates with clinically aggressive pancreatic tumors. Upon discovering the importance of mixed-lineage kinase 4 (MLK4) in IL-17RB signal transduction, it was found that two identical subunits of IL-17RB need to form a complex, a homodimerize, to be able to recruit MLK4. Moreover, phosphorylation of IL-17RB at Y447 proved vital for the recruitment of other important proteins for its downstream signaling pathway. The significance of these findings was further validated when treatment with a loop peptide dampened the phosphorylation of Y447 and reduced metastasis progression in pancreatic cancer. By understanding the signaling mechanism of IL-17RB which triggers tumorigenesis, potential treatment strategies for pancreatic tumors can be further explored.
[the_background] => Unlike other IL-17 receptors, the role and physiological nuances of IL-17RB in inflammation or pancreatic cancer remain unclear in past studies. Similarly, the binding of ligand IL-17 to the homodimer or heterodimer complex of the receptor was unknown. This study has not just answered these questions but also demonstrated the signal transduction and mediators involved in binding IL-17 to IL-17RB to elicit its tumorigenicity. The findings proved that inhibiting IL-17RB activation diminishes tumorigenesis and metastasis, reducing pancreatic tumor development, especially in-vivo. One of the limitations of the study is the inability to assess the conformational change of the receptor to recruit related mediators, which opens avenue for future studies to validate this using cryo-electron microscopy. In addition, modification on the loop peptide to target critical steps involved in IL-17RB oncogenic signaling will potentially reveal new chemical entities as candidates for treatment in pancreatic cancer.
[the_sdg_impact] => The incidence of pancreatic cancer has been increasing by the year. In 2020, close to 500,000 new pancreatic cancer incidences were recorded globally, and an almost equal number of people died of the disease. Thus, making it the 7th most common cause of cancer-related death (WHO, 2020). It is worrying that high mortality and incidence of the malignancy are correlated to high prevalence of other comorbidities, implying compromised quality of life. Hence, it is highly crucial to invest in discovering more effective treatments for this cancer to support United Nations Sustainable Development Goal (UNSDG)3: Good health and well-being, to empower the health of the global community to improve the quality of human capital.
[article_url] => https://www.science.org/doi/10.1126/scitranslmed.abc2823
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/pancreatic-4.jpg
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[publication_title] => Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer
[journal_title] => Science Translational Medicine
[publisher] => AAAS
[year] => March 2021
[subject] => Medical; Pancreatic cancer
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[post_date] => 2021-11-22 19:49:52
[post_date_gmt] => 2021-11-22 11:49:52
[post_content] =>
[post_title] => Understanding the Least Explored Branching Patterns of a Jellyfish’s Tentacles
[post_excerpt] =>
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[researchers_name] => KUMANO, Gaku (熊野岳)
[researchers_position] => Asamushi Research Center for Marine Biology, Graduate School of Life Science, Tohoku University, Japan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/medusa-.png
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[research_footprints] => Adhesive organ; Branching morphogenesis; Cladonema pacificum; Cnidarian; Jellyfish; Medusa tentacle; Mesoderm; Nematocyst; RTK signaling
[graphic_abstract] =>
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[video] =>
[the_novelty] => This study highlights the unique formation of medusa tentacles in jellyfish, C. pacificum, and the mechanisms involved. The formation of these tentacles followed a simple branching rule observed only in this species combined with a specific cell signalling, mitogen-activated protein kinase kinase (MEK) signalling. Findings indicated that tentacles branch through repeated addition of new branches to the proximal region of the main tentacle during the elongation process. Noticeably, the use of a simple rule to create complex branched structures is also found in branching morphogenesis of other animals such as Drosophila and mammals. In addition, receptor tyrosine kinase signalling could be required for the C. pacificum tentacle branch formation just like organ branch formation in Drosophila and mammals. Results also showed that changing functions of the branches from sticking to surfaces to hunting prey during the development process. As a whole, such an in-depth understanding of the unique branching features of a least studied species like the jellyfish could potentially benefit future animal development studies.
[the_background] => Branched structures are formed in certain organs of various species to carry out a range of functions. Previous literature showed the formation and functions in fruit flies’ trachea and mammalian organs such as lungs. Generally, branched tentacles are rare in jellyfishes except for jellyfishes in the Cladonematidae family. It is currently unclear how different or conserved mechanisms are involved in forming branched organs across the animal kingdom, as most available literature focused primarily on fruit flies and mammals. Therefore, this study aims to provide descriptive and functional information on the branching pattern of branched tentacles in jellyfishes.
[the_sdg_impact] => N/A
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0124-4
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/medusa-4.jpg
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[doi] => https://doi.org/10.1186/s40851-019-0124-4
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[publication_title] => Branching pattern and morphogenesis of medusa tentacles in the jellyfish Cladonema pacificum (Hydrozoa, Cnidaria)
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => March 2019
[subject] => Zoology; Biological Sciences
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[post_date] => 2021-11-22 17:39:49
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[post_content] =>
[post_title] => Uncovering the Mechanism for Treating Depression
[post_excerpt] =>
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[researchers_name] => SU, Kuan-Pin (蘇冠賓)
[researchers_position] => Departments of Psychiatry, and Mind-Body Interface Laboratory, China Medical University Hospital, Taiwan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/11/Kuan.png
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[research_footprints] => Cell biology; Molecular biology; Neuroscience
[graphic_abstract] =>
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[video] =>
[the_novelty] => What is the molecular mechanism underlying the potential of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) in treating depression and reducing neuron inflammation? Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found to have antidepressant, anti-inflammatory, and neuroprotective effects. For the first time, this study identified lipoxygenase (LOX) and cytochrome P450 (CYP450) EPA/DHA metabolites as the mediators of the protective effect of these ω-3 PUFAs. Lipid mediators hydroxyeicosapentaenoic acid (HEPE), hydroxydocosahexaenoic acid (HDHA), epoxyeicosatetraenoic acid (EpETE), and epoxydocosapentaenoic acid (EpDPA) were detected in the human brain after EPA and DHA were metabolized. Therefore, co-treatment with soluble epoxide hydroxylase (sEH) enzyme inhibitor, TPPU, was able to amplify the protective effects. Consistent results were obtained from both in vitro and clinical studies. As an extension, the research will involve a larger cohort of depressed patients and other forms of ω-3 PUFAs metabolites, such as endocannabinoids, in the future.
[the_background] => A correlation between severe depression and inflammation was reported in past studies. However, even though EPA and DHA were proven to exhibit anti-inflammatory and antidepressant properties, its mechanism remained obscure. Therefore, an effective anti-inflammatory treatment strategy is crucial. Meanwhile, there was no evidence from past literature that ω-3 lipid metabolites were produced in the human brain. For the first time, this study demonstrated that EPA and DHA were broken down in neurons into lipid mediators, which improved depressive symptoms. These findings are crucial in developing an effective therapeutic strategy for depression and other inflammation-associated brain disorders.
[the_sdg_impact] => Approximately 280 million people worldwide suffer from depression, the most common mental disorder leading to suicide. More importantly, to date, there is no effective treatment that is safe for daily use. Hence, by uncovering the mechanism in which EPA and DHA exhibit anti-inflammatory and antidepressant properties, an effective therapeutic supplement can be developed to curb depression with minimal adverse effects. In short, the output of this study contributes significantly to the development of medicines for inflammation-associated brain disorders, fulfilling UNSDG 3: Good Health & Well-Being.
[article_url] => https://www.nature.com/articles/s41380-021-01160-8
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/11/DHA-2.jpg
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[publication_title] => Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis
[journal_title] => Molecular Psychiatry
[publisher] => Springer Nature
[year] => June 2021
[subject] => Medical; Psychiatry; Depression
)
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[post_date] => 2021-11-22 17:21:18
[post_date_gmt] => 2021-11-22 09:21:18
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[post_title] => New Protein Target as Treatment Strategy in Metastatic Lung Cancer
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[researchers_name] => SHER. Yuh-Pyng (佘玉萍)
[researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan
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[research_footprints] => lung adenocarcinoma; BASP1; arsenic trioxide; EGFR-TKI acquired resistance; combination therapy
[graphic_abstract] =>
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[video] =>
[the_novelty] => The study identified an interaction between epidermal growth factor receptor (EGFR) and brain acid soluble protein-1 (BASP1) that contributes to EGFR signaling in brain metastatic lung cancer. The results demonstrated that BASP1 is associated with poorer outcomes, enhances cellular proliferation, and colony formation in lung cancer. The BASP1 role in tumorigenicity was proven via in-vitro and in-vivo by investigating the migration and metastatic potential of the protein of interest in this tumor. One of the most important discoveries of this research is the interaction between BASP1 and EGFR that enhances EGFR signaling, which activates a positive feedback loop by recruitment of BASP1 to lipid rafts. This finding enabled the researchers to identify the harmful impact of BASP1 in reducing drug sensitivity in lung cancer treatment. The light shed on the role of BASP1 via these discoveries encouraged the scientists to identify potential synergistic treatment options for lung cancer with arsenic trioxide and tyrosine kinase inhibitors (TKI) combination. Future studies exploring the functions of BASP1 based on its localization in different tumors can further reveal the universal role of the protein in various malignancies.
[the_background] => TKIs targeting EGFR are among the first-line treatment options for metastatic non-small cell lung cancer (NSCLC). However, the development of resistance over time eventually renders the treatment ineffective. Hence, it becomes crucial to discover therapeutic strategies that inhibit alternative tumor survival signaling pathways that maintain persistent oncogenic EGFR signaling. This study explored the interaction between BASP1 and EGFR, especially in lung cancer with brain metastasis, and investigated potential combination treatment that targets the BASP1-EGFR axis to overcome TKIs resistance. Contrary to the known function of BASP1 as a tumor suppressor, the study revealed that BASP1 is highly expressed and associated with poorer outcomes in brain metastasis. The findings highlighted a promising outcome through blockage of the positive feedback loop between EGFR and BASP1. Thus, paving the way for future research on potential treatment strategies using EGFR TKIs for lung cancer.
[the_sdg_impact] => According to WHO, lung cancer is the most common cause of cancer-related deaths in 2020, accounting for 1.8 million deaths with 2.21 million new cases recorded. The death to new cases ratio is the highest for lung cancer, urging the discovery of an effective therapeutic regimen for the disease, especially in brain metastatic lung cancer. This study focused on identifying the molecular basis behind therapeutic failure and poor prognosis in lung cancer. Ultimately, the findings would contribute to developing possible resistant-free and more effective treatment for lung cancer. Such a study is necessary to improve clinical management of the disease and potentially reduce mortality rates (SDG 3: Good health and well-being).
[article_url] => https://www.thno.org/v10p10925.htm
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[doi] => https://doi.org/10.7150/thno.49425
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[publication_title] => Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression
[journal_title] => Nanotheranostics
[publisher] => Theranostics
[year] => August 2020
[subject] => Medical; Biomedical Sciences; Lung Cancer
)
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[post_author] => 154
[post_date] => 2021-11-22 16:55:26
[post_date_gmt] => 2021-11-22 08:55:26
[post_content] =>
[post_title] => Potential Environmental cause of Allergic Rhinitis Development in Children
[post_excerpt] =>
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[researchers_name] => HWANG, Bing-Fang (黃彬芳)
[researchers_position] => College of Public Health, China Medical University, Taiwan
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[research_footprints] => asthma epidemiology; clinical epidemiology; paediatric lung disaese
[graphic_abstract] =>
[figures] =>
[video] =>
[the_novelty] => This study further affirms that exposures to fine particulate matter (PM2.5) during late pregnancy and early infancy increase the risk of allergic rhinitis (AR) development in a later stage. Despite the past association of PM2.5 exposure with the cause of AR, this is the first birth cohort study to identify the vulnerable time window, which is from gestation to early childhood. Potentially, such a scenario is triggered by the exposure of PM2.5 during critical stages of the sino-nasal development during late pregnancy and early infancy stages. The results would serve as a reference to determine the appropriate methods to decrease adverse effects of the condition. That said, further investigation on PM2.5 association with AR development is needed to verify the vulnerable time window suggested by this study.
[the_background] => Allergic rhinitis (AR), also called hay fever, is a series of inflammatory reactions triggered by environmental or indoor allergens, such as pollen, dust, skin flake, and mold. While AR is not a life-threatening disease, the array of symptoms associated with the condition is known to cause significant inconvenience to those diagnosed with it. Past studies have linked fine particulate matter (PM2.5) exposure with several allergic respiratory diseases, yet its role in AR development remains unclear. Moreover, there are conflicts between findings in Asian and Western countries regarding long-term PM2.5 exposure and AR incidence. Therefore, this study combined a large population-based birth cohort study with satellite data to identify the PM2.5 exposure period and evaluate its impact on the onset of AR.
[the_sdg_impact] => An article in Medscape highlighted that allergic rhinitis incidence had increased worldwide. Approximately 40% of children are affected, of which the highest prevalence of severe AR is found in Africa and Latin America. Similarly, the air quality has deteriorated over the years due to pollution and high levels of fine particulate matter in the air continue to impose greater health concerns. Thus, the study findings are essential to healthcare practitioners to advise expectant mothers and mothers of newborns to take appropriate measures to ensure the healthy development of their children (SDG 3: Good health and well-being).
[article_url] => https://thorax.bmj.com/content/early/2021/01/26/thoraxjnl-2020-215025.info?versioned=true
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[publication_title] => Effect of exposure to fine particulate matter during pregnancy and infancy on paediatric allergic rhinitis
[journal_title] => Environmental Exposure
[publisher] => BMJ
[year] => June 2021
[subject] => Medical; Occupational Safety and Health
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[post_date] => 2021-09-28 09:31:57
[post_date_gmt] => 2021-09-28 01:31:57
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[post_title] => Neutral Particle Analyzer Optimizing to Improve Tokamak Performance
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[researchers_name] => LUO, Yuan (罗圆)
[researchers_position] => Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, China
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/Yuan-Luo.png
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[researchers_name_2] => LIN, Weiping (林炜平)
[researchers_position_2] => Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, China
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/08/weiping.png
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[research_footprints] => pressure distribution; International Thermonuclear Experimental Reactor; GEANT4; cross section; magnetic field; experimental advanced superconducting tokamak; Tokamak Fusion Test Reactor; computational fluid dynamics; charge exchange; Joint European Torus
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/08/NST_Article-12_V0.jpg
[figures] =>
[video] =>
[the_novelty] => This study constructed a windowless gas stripping room with two differential pipes in a neutral particle analyzer (NPA) with parallel electric and magnetic fields (E//B), a diagnosis device in Tokamak (toroidal device used in nuclear fusion research for magnetic confinement plasmas). As a result, the new design eliminated the replacement of stripping foils and eased the operation maintenance process. Moreover, multiple simulations, such as ANSYS Fluent, MolFlow+, and GEANT4, were applied to evaluate the design performance in terms of gas pressure distribution and stripping efficiency. It was identified that the optimum pressure for maximum global efficiency is 240 Pa. In the long run, the findings could improve the NPA diagnosis for the nuclear fusion study.
[the_background] => As a diagnosis device in the Tokamak, an NPA measures the charge exchange neutral particles escaping from plasma. Its functions include studying the energy distribution of fast ions and the isotopic ratio of the plasma. An NPA consists of a stripping unit that re-ionizes the neutral particles escaping from the Tokamak through charge exchange reactions. The stripping unit comprises stripping material in the form of either stripping foil or stripping gas. This study designs and simulates a windowless gas stripping room with two differential pipes in an E//B NPA to improve the device’s performance and maintenance, especially in terms of optimum pressure for maximum global efficiency. The simulation results would serve as a reliable reference for future practical applications.
[the_sdg_impact] => At present, power plants generate electricity and energy through fossil fuels, nuclear fission, or renewable energy sources. A Tokamak is an experimental machine designed to harness the energy of nuclear fusion, potentially serving as an alternative to future energy generation. To turn such experimental design into reality, it is crucial for researchers to constantly explore new ways to improve and maintain the performance of the Tokamak facility. Therefore, the findings of this study contribute to the efforts of the understanding and the betterment of the device. It would eventually be beneficial to advance the future of energy production. (UNSDG 9: Industry, Innovation & Infrastructure)
[article_url] => https://link.springer.com/article/10.1007/s41365-021-00909-8
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/Tokamak.jpg
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[publication_title] => A simulation study of a windowless gas-stripping room in an E//B neutral particle analyzer
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => July 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_date] => 2021-09-26 16:17:47
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[post_title] => Fast and Accurate Way to Detect Special Nuclear Materials Being Smuggled
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[researchers_name] => LAN, Haoyang
[researchers_position] => School of Nuclear Science and Technology, University of South China, China
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[researchers_name_2] => LUO, Wen
[researchers_position_2] => School of Nuclear Science and Technology, University of South China, China
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[research_footprints] => region of interest; standard deviation; nuclear material; nuclear resonance fluorescence; spectroscopy; special nuclear material
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/09/NST_Article-13_V2-2.jpg
[figures] =>
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[the_novelty] => This study proposed an improvement to the existing special nuclear materials (SNMs) detection models by combining two spectroscopy techniques, i.e., scattering nuclear resonance fluorescence (sNRF) and transmission-NRF-based computed tomography (tNRF-CT). The combination enabled the proposed detector to identify isotopic composition and spatial distribution of 235,238U when concealed in a 3-cm diameter iron rod. The outcome indicated a shortened interrogation time by one order of magnitude, making it a more rapid and sensitive option than the current tNRF-CT approach. Thus, the successful attempt of the proposed model in lowering the missed-detection rate within a realistic interrogation time would be of great value to upgrade national and global security systems.
[the_background] => The integrity of global security has constantly been threatened due to the potential smuggling of special nuclear materials (SNMs) across borders and through ports of entry. As a matter of fact, the Incident Trafficking Database developed by the International Atomic EnergyAgency has reported several hundred incidents of illicit trafficking and malicious use of certain nuclear and radioactive materials. Existing passive detection systems are ineffective when the interrogated SNMs are shielded, considering the low spontaneous radiation intensity and energy emitted in most cases. Therefore, this study proposed an active detection technique that uses external radiation sources to develop a more accurate, effective, and practical approach to non-destructively inspect SNMs, especially uranium.
[the_sdg_impact] => International organizations such as the Nuclear Threat Initiative (NTI) in the U.S. and the United Nations Office for Disarmament Affairs (UNODA) are constantly trying to strengthen global security against threats, one of which is nuclear terrorism. Hazardous nuclear materials falling into the wrong hands could lead to catastrophic events ranging from poisoning and radiation burns to nuclear attacks. To prevent such incidents, security systems need to be constantly upgraded, especially in terms of material inspections at borders, ports, and checkpoints. This study proposed a feasible technique to improve the non-destructive inspection capability of special nuclear material (SNM) through an innovative combination of imaging technologies. The outcome indicates that integration of such techniques could be beneficial to strengthening national and international security systems against nuclear smuggling, in extension, maintaining world peace. (UNSDG 9: Innovation, industry and infrastructure; UNSDG 16: Peace, justice and strong institutions)
[article_url] => https://link.springer.com/article/10.1007/s41365-021-00914-x
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[publication_title] => Rapid interrogation of special nuclear materials by combining scattering and transmission nuclear resonance fluorescence spectroscopy
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[year] => August 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_title] => Baseline Test Results of 650 MHz Cavities BCP Treated for CEPC
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[researchers_name] => SHA, Peng (沙鹏)
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[original_article_reference] =>
[research_footprints] => radio frequency; superconducting radio frequency; Fermi National Accelerator Laboratory; circular electron positron collider; quality factor
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/09/NST_Article-11_V1.jpg
[figures] =>
[video] =>
[the_novelty] => This study has found that nitrogen doping/infusion could increase the intrinsic quality factor (Q0) of the 650 MHz cavities used in a circular electron-positron collider (CEPC). Adopting a buffered chemical polishing (BCP) surface baseline prior to the nitrogen infusion of a 650 MHz 2-cell cavity yielded a Q0 of 6 × 1010 at 22 MV/m in the vertical test and a maximum gradient of 25 MV/m. The Q0 exceeded the specification of CEPC, i.e., 4 × 1010 at 22 MV/m. By optimizing nitrogen infusion and BCP, the performance of the 650 MHz cavity can be further enhanced.
[the_background] => The CEPC is a high-energy collider of the Higgs factory. Constructed 100 m underground, two hundred and forty 650 MHz 2-cell cavities and ninety-six 1.3 GHz 9-cell cavities exist in the collider and the booster. The 650 MHz 2-cell cavities economically support the cryogenics system by operating in continuous wave mode with high-quality factor (Q). Electro-polishing (EP) is commonly adopted for the nitrogen doping/infusion of the cavities abroad. However, in China, buffered chemical polishing (BCP) is relatively more feasible to be adopted instead. This study conducted a nitrogen infusion and doping study on 650 MHz cavities BCP treated to confirm its feasibility. Results showed that the Q0 achieved exceeded the specifications of CEPC. Therefore, nitrogen doping/infusion of cavities BCP treated is effective and easy to promote.
[the_sdg_impact] => Superconducting cavities with high Q and gradient are advocated by many applications, such as wastewater and sludge treatment, safety, flue gas treatment, nuclear waste destruction, etc. The highly effective BCP surface baseline reported in this study offers an alternative option to researchers seeking a feasible surface baseline for nitrogen doping/infusion besides EP. Hence, this study aligns with the objectives of UNSDG 9: Industry, Innovation & Infrastructure, to enhance scientific research.
[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00881-3
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/09/CEPC3.jpg
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[doi] => https://doi.org/10.1007/s41365-021-00881-3
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[publication_title] => Nitrogen doping/infusion of 650 MHz cavities for CEPC
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => May 2021
[subject] => Engineering; Nuclear Physics; Nuclear Technology; Applied Physics
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[post_date] => 2021-09-17 10:33:30
[post_date_gmt] => 2021-09-17 02:33:30
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[post_title] => Formation of Fin Rays Pattern of Zebrafish
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[researchers_name] => TAMURA, Koji (田村宏治)
[researchers_position] => Department of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku University, Japan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/09/Zebrafish.png
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[researchers_name_2] => ABE, Gembu (阿部玄武)
[researchers_position_2] => Department of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku University, Japan
[researchers_photo_2] => https://iesresearch.solutions/wp-content/uploads/2021/09/Zebrafish-2.png
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[research_footprints] => danio rerio; limb development; standard length; polymerase chain reaction; phenotypic variation; fin ray; zone of polarizing activity; apical ectodermal ridge
[graphic_abstract] =>
[figures] => https://iesresearch.solutions/wp-content/uploads/2021/09/Zebrafish-6.png
[video] =>
[the_novelty] => This study showed that the connections between fin rays and distal radials influence patterns exhibited by zebrafish's pectoral fin rays along the antero-posterior (AP) axis. Through detailed morphological observation, it was noted that the formation of the pattern relied on the developmental genes for AP patterning in the limb/fin bud. Such developmental mechanisms were similar to those of the distal element of the limb skeleton. The reported topological relationships and development processes serve as valuable literature to facilitate studies related to the skeletal patterns of fish.
[the_background] => Fin rays are rod-like support of the fin membrane. They are often observed in various fish and are attached to the distal radials to exhibit patterns. However, there were limited reports on pattern formation. Furthermore, the topological relationships, as well as the developmental process between the fin rays and distal radials, were ambiguous. This study intended to investigate the topological relationships, which are the structural organizations, and developmental mechanisms in forming patterns of fin rays along the antero-posterior axis. The findings also showed how different parts of zebrafish are closely related in the development to form important structures for supporting daily activities.
[the_sdg_impact] => Morphological studies contribute to a range of implications, be it to deepen the understanding of the biological evolution of organisms or design development of infrastructure. The techniques used in this study do not just provide deeper insights into the structures of zebrafish's fin ray and distal radials; instead, the findings could potentially be useful to marine researchers interested in exploring similar structures of other aquatic creatures. Directly and indirectly, such understanding could provide better solutions in sustaining marine resources (UN SDG 14: Life below water). Moreover, understanding fin design and development is crucial in diversifying hydrodynamics-related experiments and features needed to build resilient infrastructure and foster innovation (UN SDG 9: Industry, innovation, and infrastructure).
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0145-z
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/09/Zebrafish3.jpg
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[publication_title] => Pattern of fin rays along the antero-posterior axis based on their connection to distal radials
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => September 2019
[subject] =>
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[post_date] => 2021-09-07 09:28:18
[post_date_gmt] => 2021-09-07 01:28:18
[post_content] =>
[post_title] => Rare and Extraordinary Structural Characteristics of the Common Freshwater Moss Animal - Stephanella Hina
[post_excerpt] =>
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[researchers_name] => HIROSE, Masato (広瀬雅人)
[researchers_position] => School of Marine Biosciences, Kitasato University, Japan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/09/bryozoan-5-1.png
[researchers_profile] => https://www.researchgate.net/profile/Masato-Hirose
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[research_footprints] => morphology; scanning microscopy; Stephanellidae; laser scanning; Epistome; sister group
[graphic_abstract] =>
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[video] =>
[the_novelty] => The study found that the general structural characteristics between Stephanella hina and other freshwater bryozoans (moss animals) were not too different. However, Stephanella hina did possess distinct cladistic traits, separating it from the rest of the freshwater bryozoans. The most distinctive feature of Stephanella hina, according to the in-vivo analysis, is their lophophore structure and neuromuscular intricacies, differing from other Phylactolaemate bryozoans. However, it remains unclear if these differences are biologically classified as non-ancestral (apomorphic) or ancestrally shared (plesiomorphic), suggesting a potential future expansion.
[the_background] => This research describes features that differentiate Stephanella hina from other Phylactolaemate bryozoans. Bryozoa are essentially a category or phylum comprising aquatic colonies that are especially diverse in marine areas. Phylactolaemata is a division within Bryozoa that describes colonies native to freshwater, such as Stephanella hina. There has not been much detailed research conducted on Stephanella hina to properly understand the structural characteristics of this species. Therefore this study performed a thorough in-vivo analysis to fulfill the research gap. This study suggests an analysis of the family Lophopodidae, the early branch in Phylactolaemate bryozoans, to truly understand if the differences found were ancestral (plesiomorphic) or non-ancestral (apomorphic).
[the_sdg_impact] => A quick observation of Stephanella hina distribution through NatureServe Explorer (see: https://explorer.natureserve.org/Taxon/ELEMENT_GLOBAL.2.119240/Stephanella_hina) will reveal that much about the species is a mystery aside from generic taxonomic information. Since the Phylactolaemate bryozoans are the early branch of the phylum Bryozoa, describing and understanding the structural characteristics of this group, as such, findings from this research would also contribute to increased scientific knowledge per Sustainable Developmental Goal 14.A to further advance marine health. Understanding the differences between Stephanella hina and other Phylactolaemate bryozoans allows effective enactment of SDG 14.5 to conserve at least 10 percent of coastal and marine areas based on reliable scientific information through means that complement the differences. Understanding the origin of these differences is crucial to determine if the differences are plesiomorphic or apomorphic to further enhance scientific and conservation efforts.
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-00165-5
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/09/bryozoan-2.jpg
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[publication_title] => Morphology of Stephanella hina (Bryozoa, Phylactolaemata): common phylactolaemate and unexpected, unique characters
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => November 2020
[subject] => Zoology; Marine Biosciences
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[post_date] => 2021-09-06 21:39:48
[post_date_gmt] => 2021-09-06 13:39:48
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[post_title] => Higher Efficiency Targeted Gene Integration in Medaka
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[researchers_name] => KINOSHITA, Masato (木下政人)
[researchers_position] => Graduate Schools Agriculture, Kyoto University, Japan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/09/medaka-.png
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[researchers_second_profile] => https://orcid.org/0000-0003-3936-7371
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[research_footprints] => Homology-directed repair; Medaka; microhomology-mediated end joining; sodium dodecyl sulfate; central nervous system; mutagenesis; bacterial artificial chromosome; homologous recombination; clustered regularly interspaced short palindromic repeats; transcription activator; genome editing; oryzias; non-homologous end-joining
[graphic_abstract] =>
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[video] =>
[the_novelty] => The CRISPR/Cas is a tool known for its targeted gene integration, yet there is room for overall efficiency enhancement. This study demonstrated that targeted gene integration events could be induced more efficiently using donor plasmids with longer homology arms than those with shorter homology arms. Besides that, linearization of circular donor plasmids and utilization of suitable bait sequences also increased the efficiency. The targeted gene integration events were attempted using CRISPR/Cas system and donor plasmids with homologous sequences in medaka (Oryzias latipes). The results implied that its efficiency was possible to be further increased via suitable techniques.
[the_background] => The CRISPR/Cas system is a powerful genome-editing tool. Despite being well-known for its potential, the number of reports on targeted gene integration using the CRISPR/Cas system was scarce. This implied the availability of room for optimization on the performance of this system. Therefore, via in vivo and in silico experiments, this study attempted to enhance the efficiency of targeted gene integration events in medaka. Such effort paves a path for related future research to be carried out more effectively using similar methods in other fish species.
[the_sdg_impact] => Gene-editing technology is capable of re-designing the genome of organisms and plants. Imperfections, such as inherited illness, are possible to be eliminated in the offsprings through this technology. Meanwhile, the techniques to increase the efficiency of the CRISPR/Cas system create higher possibilities to achieve better results in gene editing. By introducing these techniques, the outcome of this study is able to facilitate future studies which adopt the CRISPR/Cas system. Hence, this research is well-aligned with UNSDG 9: Industry, Innovation & Infrastructure by enhancing scientific research.
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-017-0071-x
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/09/medaka-2.jpg
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[publication_title] => An efficient system for homology-dependent targeted gene integration in medaka (Oryzias latipes)
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => July 2017
[subject] => Zoology; Agriculture
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[post_date] => 2021-08-25 15:50:02
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[post_title] => Cancer-Inducing Ligand-Receptor Pair
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[researchers_name] => HUNG, Mien-Chie (洪明奇)
[researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/r1-1.png
[researchers_profile] => https://www.researchgate.net/profile/Mien-Chie-Hung
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[research_footprints] => ligand-binding domain; breast cancer; tyrosine kinase; lymph node; western blotting; extracellular domain; horseradish peroxidase; tissue microarray; standard deviation; American Type Culture Collection; phosphate-buffered saline; epidermal growth factor receptor; proximity ligation assay; ephrin a4; hepatocyte growth factor receptor; E. coli; small hairpin RNA; receptor tyrosine kinase
[graphic_abstract] =>
[figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/ribonuclease-4.png
[video] =>
[the_novelty] => This study disclosed a ligand-receptor relationship that played a significant role in initiating the growth of breast tumors. Human antibody array studies identified hRNase1 as a ligand for EphA4 and that the hRNase 1-mediated EphA4 signaling led to breast cancer development. Moreover, the impact of RNase 1–EphA4 ligand-receptor relationship was consistent with those of hRNase 5–EGFR and hRNase 7–ROS1 in promoting tumor growth. Therefore, further studies focusing on RNase–RTK targeted inhibition would contribute to new therapeutic strategies for various cancers.
[the_background] => Despite the extensive studies on the biochemical properties of hRNase 1, the actual biological function of hRNase 1 has yet to be determined. Meanwhile, the ligand-receptor relationships of hRNase 5–EGFR and hRNase 7–ROS1 were proven to result in tumor growth. Based on those findings, there are reasons to believe that hRNase 1 has similar involvement in cancers. On the other hand, the upregulation of receptor EphA4 in breast cancer stem-like cells (CSCs) indicates the possibility of treating cancer via EphA4 inhibition. Thus, this study investigated the implication of the hRNase 1–EphA4 ligand-receptor relationship in breast cancers. Identifying the critical role of the hRNase 1–EphA4 pair in breast cancer initiation implied that the initiation of other cancers could be due to similar ligand-receptor relationships. Thus, setting a clear study scope for future anti-tumor research.
[the_sdg_impact] => In 2020, 2.3 million women were diagnosed with breast cancer globally. This suggests that there is an urgent need for the development of more promising therapies to treat breast cancer. Along with the findings derived from the studies of hRNase 5–EGFR and of hRNase 7–ROS1 pairs, this study established a firm validation associating RNase–RTK pairs to the root cause of cancers. By identifying the possible pathways for cancers, this study expands the possibility of deriving potentially effective cancer interventions in the near future (UNSDG 3: Good Health & Well-Being).
[article_url] => https://www.nature.com/articles/s41467-021-23075-2
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[publication_title] => Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
[journal_title] => Nature Communications
[publisher] => Springer Nature
[year] => May 2021
[subject] => Medical; Biomedical Sciences; Cancer
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[post_date] => 2021-08-19 11:56:26
[post_date_gmt] => 2021-08-19 03:56:26
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[post_title] => Tannic Acid as Dual-Action Remedy for COVID-19
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[researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan
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[research_footprints] => COVID-19; prostate cancer; TMPRSS2; SARS-CoV-2; serine protease; tannic acid; surface plasmon resonance; severe acute respiratory syndrome
[graphic_abstract] =>
[figures] => https://iesresearch.solutions/wp-content/uploads/2021/08/Tannic-4-.jpg
[video] =>
[the_novelty] => This study identified the potential of tannic acid (a compound found in fruits and plants) as a natural remedy for COVID-19. Results from in vitro experiments showed that tannic acid was able to inhibit the activity of coronavirus SARS-CoV-2’s main protease. Furthermore, tannic acid also prevented the entry of SARS-CoV-2 into cells by inhibiting the human cell surface protease TMPRSS2. By acting as an effective dual inhibitor of the two main proteases involved in coronavirus SARS-CoV-2 infection, the clinical trial of tannic acid in treating COVID-19 is highly anticipated. Meanwhile, since TMPRSS2 is also responsible for prostate cancer progression, future studies can be conducted to examine the potential of tannic acid in suppressing cancer progression through TMRPSS2 inhibition.
[the_background] => From the perspective of biological science, the COVID-19 pandemic can be overcome by deactivating the main protease of coronavirus SARS-CoV-2 and blocking the entry of SARS-CoV-2 into human cells. But, how? In order to prevent the cellular entry of SARS-CoV-2, human cell surface protease TMPRSS2 should be targeted as it was reported to form an ‘entrance’ for such invasion. Various natural compounds from fruits and plants exhibited anti-coronavirus properties. Hence, this study was carried out to determine the potential of tannic acid (a natural compound) in suppressing SARS-CoV-2. The outcome showed that tannic acid was able to deactivate the main protease of coronavirus SARS-CoV-2 and also managed to block the cellular entry of SARS-CoV-2 via inhibition of protease TMPRSS2. The dual action of tannic acid indicated its high potential in battling COVID-19.
[the_sdg_impact] => To date, scientists are still working towards effective remedies to deal with COVID-19 while the global death toll rises. Although numerous vaccination programs have been rolled out globally, the frequent mutation rate to generate viral variants of SARS-CoV-2 has raised the necessity to develop anti-Covid-19 drugs. Therefore, a possible treatment with minimal side-effect is needed as soon as possible. The discovery of tannic acid’s potential as a low-risk yet feasible compound for treating COVID-19 could inspire more magnificent research in a similar direction. Thus, by achieving significant milestones in the research and development of vaccines and medicines for COVID-19, this study contributes to the realization of UNSDG 3: Good Health & Well-being.
[article_url] => https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783773/
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[publication_title] => Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease
[journal_title] => American Journal of Cancer Research
[publisher] => e-Century Publishing Corporation
[year] => December 2020
[subject] => Medical; Covid-19
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[post_title] => How Do Antioxidant Components in Blueberries Conduct Whitening Activities in Skin Cells and Animals?
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[research_footprints] => melanocortin 1 receptor; bovine serum albumin; acridine orange; pterostilbene; fetal bovine serum
fluorescein isothiocyanate; cAMP response element-binding protein; keratinocyte; dimethyl sulfoxide; Nrf2; reactive oxygen species; polyvinylidene difluoride; autophagy; protein kinase A; microphthalmia-associated transcription factor
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/08/antioxidant-4.jpg
[figures] =>
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[the_novelty] => This novel study revealed the whitening activities of an antioxidant component in blueberries (Pterostilbene) in cells and animals. This was achieved by triggering the melanin cell autophagy mechanism (self-eating) and disabling UV (Ultraviolet)-damaged hormones in keratinocytes through an antioxidant pathway. The findings showed that Pterostilbene activated the Nrf2 antioxidant gene in keratinocytes, stimulating the HO-1 and γ-GCLC antioxidant enzymes. It also increased the autophagy-associated proteins, LC3-II and p62, while simultaneously decreasing the ATG4B protein in melanocytes. Thus, the cells produced their own antioxidants, leading to the inhibition of melanin production. This study can further expand by researching the mechanism involved in Pterostilbene interfering with the melanosome maturation process to better understand its whitening properties.
[the_background] => UV radiation such as UV-A and UV-B rays can penetrate the skin and increase melanin production, causing dark skin spots. Chinese herbal medicine has 13 approved whitening ingredients, which mainly inhibit melanin production and pigmentation. One such ingredient is Resveratrol. Unfortunately, most commercially available sunscreens are not able to resist UV-A rays. However, Pterostilbene is seen as a powerful natural antioxidant that can be applied onto the skin to achieve the whitening effect. Previous studies reported cell autophagy and deactivation of hormones in skin cells aid in Pterostilbene’s whitening effects in various cells and lab animals. However, this is one of the first studies to explain the molecular processes of Pterostilbene’s whitening effects in keratinocytes and melanocytes. In addition, the study uses Zebrafish embryos to prove Pterostilbene’s effectiveness as a whitening component in skin-whitening agents.
[the_sdg_impact] => According to past literature, it was found that the UV radiation in China decreased from 1961 to 1991. However, there seems to be an increase in UV radiation from 1991 to 2012. Similar could be observed with other parts of the world. With increasing UV radiation, more UV-A rays can penetrate the skin and trigger the melanocytes to increase melanin production, leading to dark spot formation on the skin. This can cause frustration and emotional stress in an individual. More research needs to be conducted to identify an effective whitening component to ensure that people can successfully treat these dark skin spots. The aim of this study is aligned with the “Goal 3: Good Health and Well-Being” of the UN’s Sustainable Development Goals. This research could allow the use of Pterostilbene in treating skin diseases caused by UV-A rays.
[article_url] => https://www.sciencedirect.com/science/article/pii/S2213231721001658?via%3Dihub
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[publication_title] => The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated α-MSH in keratinocytes via Nrf2-mediated antioxidant pathways
[journal_title] => Redox Biology
[publisher] => Elsevier
[year] => August 2021
[subject] => Medical; Biology
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[post_title] => TYRO3: The Reason Behind Anti–PD-1/PD-L1 Immunotherapy Resistance in Cancer Treatment
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[research_footprints] => gene expression omnibus; triple-negative breast cancer; damage-associated molecular pattern; t cell; arginase 1; immune checkpoint blockade; thiobarbituric acid; tumor cell; triple-negative breast; cancer; ferritin light chain; ferroptosis; tumor microenvironment; therapeutic target
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/08/immunotherapy-4.jpg
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[the_novelty] => This study is a novel attempt to investigate receptor tyrosine kinase (RTKs) that could potentially contribute to the resistance of anti-programmed cell death protein 1/ programmed death-ligand 1 (anti- PD-1/ PD-L1) therapy in cancer. The outcome showed a significant association between tyrosine receptor kinase protein 3 (TYRO3) and anti-PD-1/ PD-L1 therapy resistance in different tumors. A series of comprehensive research designs, cellular (in-vitro), animal (in-vivo), and retrospective computer (in-silico) analysis on multiple databases, revealed that the high expression and phosphorylation status of TYRO3 correlates to poorer prognosis in anti- PD-1/ PD-L1 treatment and causes resistance. Furthermore, TYRO3 was also found to be suppressing ferroptosis, a nonapoptotic, iron-dependent form of cell death via the AKT/ NFR2 pathway, thus diminishing the sensitivity of cancer cells to anti- PD-1/ PD-L1 treatment. Overall, the study implicates the protein's role as a potential biomarker for patient stratification and therapeutic options.
[the_background] => Immunotherapy that involves blockade of PD-1/ PD-L1 has been clinically gaining interest in cancer treatment due to its anti-tumor potential. Nevertheless, the response rate of PD-1/PD-L1 antagonism as a single therapy in cancer treatment has been relatively low owing to resistance to the therapy and insufficient biomarkers to select patients for treatment. Although there has been emerging evidence of the TAM (TYRO3, AXL, and MerTK) family's role in host immune response, this study proved that TYRO3 participates in eliciting resistance in anti- PD-1/ PD-L1 treatment, and not AXL or MerTK. Following the recent success of RTK inhibitors in cancer treatment, the findings can potentially pave ways to develop therapeutic targets on TYRO3. Considering the structural similarity of TYRO3 to AXL and MerTK, more in-vivo studies should be done in the future to confirm the specificity of the protein's role in contributing to treatment resistance. The study must also be duplicated in different malignancies to understand the protein's universal function and therapeutic efficacy in other tumors.
[the_sdg_impact] => Global oncology spending has steadily increased from USD 56 billion to USD 187 billion from 2011 to 2021, close to a four-fold increase in just a decade (Statista). The economic toll is approximately 19% higher than heart disease, the second leading cause of economic loss following cancer (American Cancer Society). These staggering figures are continuous reminders of the urgent need for targeted therapies and biomarkers in improving the efficacy of cancer treatment. This study builds on the evidence and contributes towards the potential development of RTK inhibitor therapy and biomarkers in different cancers. Thus, it helps realize the United Nation's Sustainable Development Goal, UNSDG 3: Good health and well-being, by contributing to developing therapeutics for a disease that enormously costs the global economy and quality of life.
[article_url] => https://www.jci.org/articles/view/139434
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/immunotherapy-.jpg
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[publication_title] => TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis
[journal_title] => The Journal of Clinical Investigation
[publisher] => American Society for Clinical Investigation
[year] => April 2021
[subject] => Medical, Cancer; Immunotherapy
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[post_date] => 2021-08-19 11:44:05
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[post_title] => TET2 Regulates the Development of Breast Tumor and Response to Anti-estrogen Treatment
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[post_name] => tet2-regulates-the-development-of-breast-tumor-and-response-to-anti-estrogen-treatment
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[researchers_name] => YANG, Jer-Yen (楊哲彥)
[researchers_position] => Graduate Institute of Biomedical Sciences, China Medical University, Taiwan
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[research_footprints] => chromatin immunoprecipitation; Cytokeratin 14; mammary gland development; long terminal repeat; ;epigenetic regulation; terminal end bud; Cytokeratin 8; cell fate
[graphic_abstract] =>
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[video] =>
[the_novelty] => This study emphasizes the role of TET2 in breast cancer development. TET2 is shown to form a complex with transcription factor FOXP1 to mediate the expression of ESR1, GATA3, and FOXA1 genes that are responsible for the development of the mammary gland and response to hormones. Loss of TET2 leads to silenced estrogen receptors (ER) expression, consequently promoting intrinsic resistance to tamoxifen. These findings are of vast clinical significance, elucidating the potential for loss of TET2 expression as a biomarker to predict the resistance to anti-estrogen treatment. Additionally, these findings offer a new avenue of restoring TET2 activity to treat breast cancer patients exhibiting intrinsic resistance to hormone therapy.
[the_background] => TET2, a DNA demethylation enzyme, commonly found in the mammary gland, plays a pivotal role in regulating mammary stem cells' (MaSc) homeostasis. MaSC generates progeny cells responsible for the formation of the mammary gland. Past research has very much linked suppression of TET2 to impaired, cancer-like cell division through in-vitro studies. However, little is known of the role of TET2 in regulating MaSC homeostasis and tumor development in-vivo. CMU researchers have found that loss of TET2 expression could result in impaired differentiation from MaSC to the inner cell lining of the mammary gland, leading to the development of aggressive breast cancer using a mouse model. Therefore, findings from this study offer insight into a new role of TET2 in the development of breast cancer and resistance to anti-estrogen treatment.
[the_sdg_impact] => The past five years have seen approximately 7.8 million women diagnosed with breast cancer, with a staggering 685 000 deaths reported globally just last year (WHO, 2021). There is an urgent need for early detection, rapid diagnosis, and effective treatment methods considering how breast cancer accounts for the highest prevailing form of cancer. This study offers potential in fulfilling Sustainable Development Goals (SDG) 3.4, calling for reducing one-third of mortality caused by non-communicable diseases like breast cancer. Its findings on the role of TET2 can be regulated favorably to promote response towards tamoxifen. Likewise, it provides the potential for detecting hormone therapy resistance using the loss of TET2 as a biomarker.
[article_url] => https://www.nature.com/articles/s41467-020-18129-w
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/08/TET2-2.jpg
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[publication_title] => TET2 directs mammary luminal cell differentiation and endocrine response
[journal_title] => Nature Communications
[publisher] => Springer Nature
[year] => September 2020
[subject] => Medical; Breast Cancer
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[post_title] => Tumor Eradication through nPD-L1-mediated Pyroptosis
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[research_footprints] => nuclear export signal; chemotherapy drug; clustered regularly interspaced short palindromic repeats; lactate dehydrogenase; nuclear localization signal; apoptosis; macrophage; breast cancer; cancer cell; gasdermin D; tumour; necrosis factor α; chromatin immunoprecipitation
[graphic_abstract] =>
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[the_novelty] => This research revealed an antibiotics-induced cellular pathway that could effectively kill tumor tissues. The mechanism occurs when the cells are deprived of oxygen, whereby nuclear-programmed death-ligand 1 (nPD-L1) enables pyroptosis (instead of apoptosis) programmed death in cancer cells. Sequentially, it involves interactions between p-Stat3 and nPD-L1, transcription of the gasdermin C (GSDMC) gene, cleavage of GSDMC by caspase-8 (activated by TNFα), and, eventually, death of cancer cell due to pyroptosis. Unlike PD-L1, the role of nPD-L1 in this particular anti-tumor pathway did not involve any checkpoint inhibitor. Further investigation can be conducted to study its feasibility in treating different types of cancer.
[the_background] => PD-L1 is usually located in the cell surface and has been a common target for checkpoint inhibition immunotherapy. Meanwhile, little is known of the exact role and purpose of PD-L1 located in the nucleus (i.e., nPD-L1). Compared to apoptosis (a cell’s natural mechanism for programmed death), pyroptosis (an inflammatory programmed cell death) in cancer cells showed more promising results in killing tumor tissues. Upon determining the function of nPD-L1, this research demonstrated nPD-L1’s ability to mediate the switch from apoptosis to pyroptosis, which successfully killed tumor tissues under hypoxia. These significant findings show high potential in the development of a new anti-cancer therapy.
[the_sdg_impact] => There are more than 100 types of cancer, which implies humans' high vulnerability towards cancer. Hence, cancer-related studies are essential not only for increasing patients’ survival rates, but also to provide advanced knowledge of the human body, especially the immune system. The new method to kill cancer cells discussed in this study is a valuable effort to support the research and development of cancer treatment (UNSDG 3: Good Health & Well-being).
[article_url] => https://www.nature.com/articles/s41556-020-0575-z
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[publication_title] => PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
[journal_title] => Nature Cell Biology
[publisher] => Springer Nature
[year] => September 2020
[subject] => Medical; Cancer
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[post_title] => Antitumor Pathway Involving Galectin 9, PD-1 and TIM-3
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[research_footprints] => extracellular domain; T helper; E. coli; tumor necrosis factor receptor superfamily; antigen-presenting cells; fetal bovine serum; treg cell; immunotherapy; dendritic cells; cell death; tumor microenvironment
galectin; The Cancer Genome Atlas; immune response; cancer immunotherapy; room temperature; immune checkpoint; antibody-dependent cell-mediated cytotoxicity; phosphate-buffered saline
[graphic_abstract] =>
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[video] =>
[the_novelty] => This study identified a molecular mechanism responsible for promoting the survival of exhausted T-cells, which resulted in higher antitumor activity. Apart from its commonly known functions, programmed cell death protein 1 (PD-1) was able to inhibit the induced death of exhausted T-cells by binding to galectin-9 ligand (Gal-9). While letting the exhausted T-cells sustain their role in immunity, the inhibition of Gal-9 could also be a high-potential antitumor therapy, as indicated by in vitro studies. Thus, further investigations emphasizing anti-Gal-9-based cancer therapy are very likely to lead to the development of various therapies for treating a broader spectrum of cancer.
[the_background] => T cells exhaustion occurs during chronic infections and cancer, whereby the optimal control of infection and tumors is prevented. The two T cell inhibitory receptors PD-1 and TIM-3 (T-cell immunoglobulin and mucin domain-3) are co-expressed in this state. Consequently, the binding of Gal-9 to TIM-3 will induce natural programmed death of T cells, resulting in lower immunity. However, in the tumor microenvironment (TME), the exhausted T-cells persist instead. Hence, this study was conducted with interest to verify the speculation stating that the persistence was due to the inhibition of Gal-9/TIM-3 by PD-1. Other than the successful verification, its conclusion also highlighted that Gal-9 was a crucial target for immunotherapy. This forms a robust foundation for future studies related to immunotherapy.
[the_sdg_impact] => Being known as the second leading cause of death, cancer has been studied extensively for decades with the sole purpose of ending it ultimately. Therefore, scientists have persevered in exploring the most feasible therapies from various biological aspects to address the entire spectrum of human malignancies. With richer knowledge of T-cells, the outcome of this study has established a new research direction for immunotherapy. The contributions of this study are well-aligned with UNSDG 3: Good Health & Well-being.
[article_url] => https://www.nature.com/articles/s41467-021-21099-2
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[publication_title] => Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
[journal_title] => Nature Communications
[publisher] => Springer Nature
[year] => February 2021
[subject] => Medical; Cancer
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[post_date] => 2021-08-19 11:02:05
[post_date_gmt] => 2021-08-19 03:02:05
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[post_title] => Treating Liver Cancer by Inhibiting ROS1 Oncogene
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[researchers_name] => HUNG, Mien-Chie (洪明奇)
[researchers_position] => Graduate Institute of Biomedical Sciences & Center for Molecular Medicine, China Medical University, Taiwan
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[research_footprints] => ROS1; ribonuclease 7; plasma biomarker; hepatocellular carcinoma; crizotinib; cancer; ttyrosine kinase; signaling; treatment stratification; liver cancer
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/08/ROS1-4.jpg
[figures] =>
[video] =>
[the_novelty] => By identifying recombinant ribonuclease RNase7 as the ligand which activates receptor tyrosine kinase ROS1, this study introduces a potential treatment for hepatocellular carcinoma (HCC). As a result of ligand-receptor relationship establishment between RNase7 and ROS1 based on both in vitro and in vivo studies, the ROS1 pathway involved in tumor growth was inhibited. Thus, the mechanism promises a potential treatment for patients with high RNase7 expression. With that said, clinical trials should be conducted to better understand the effectiveness of RNase7-ROS1 targeted therapy in treating liver cancer and other cancers.
[the_background] => Cell surface receptor ROS1 is involved in the formation of tumor cells. Therefore, ROS1 is often part of the main subject in studies related to human cancers. However, the ligand responsible for the activation of the ROS1 pathway is still unknown. Thus, such a gap in knowledge poses a major hurdle in developing effective targeted therapy for HCC. With reference to recent studies indicating RNase as a possible ligand for ROS1, this study successfully demonstrates RNase7 as the ligand of interest and that anti-ROS1 inhibition could potentially be used to treat HCC. Hence, serving as a significant milestone that brings oncology closer to discovering more effective cancer prevention and cure.
[the_sdg_impact] => The number of death due to cancer in 2018 has reached 9.6 million worldwide, making this disease the second leading cause of death globally. In other words, countless lives can be saved if feasible cancer treatments are developed and made accessible to all cancer patients. The discovery of the ROS-1 inhibition mechanism and its relationship with tumor growth provides great insights into potential HCC treatment. Such progress aligns with the objectives of UNSDG 3: Good health & well-being by propelling cancer treatment research development forward.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0168827820336746
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[publication_title] => Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma
[journal_title] => Journal of Hepatology
[publisher] => Elsevier
[year] => April 2021
[subject] => Medical; Cancer
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[post_date] => 2021-08-12 17:52:54
[post_date_gmt] => 2021-08-12 09:52:54
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[post_title] => Review on Production and Quality Requirements of Human Platelet Lysate (HPL)
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[researchers_name] => BURNOUF, Thierry
[researchers_position] => College of Biomedical Engineering, Taipei Medical University, Taiwan
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[research_footprints] => west nile virus; human leukocyte antigens; hepatitis B virus; stromal cell; creutzfeldt–jakob disease; babesia microti; fetal bovine serum; blood transfusion; platelet concentrate; zika virus; medicinal product; transmissible spongiform encephalopathies; mesenchymal stromal cells; growth factor; extracellular vesicles; hepatitis E virus; mesenchymal stem cell; hepatitis C virus; dengue virus; human cell; platelet lysate; bovine spongiform encephalopathy
[graphic_abstract] =>
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[video] =>
[the_novelty] => Human platelet lysate (HPL) has been extensively explored for cell therapy and regenerative medicine as a suitable and effective substitute for fetal bovine serum (FBS). Hence, an internationally standardized quality control protocol is needed to manage the production, safety, and quality criteria. As an attempt, this study evaluated existing literature on HPL production and outlined necessary guiding steps to ensure the maximal safety of this ancillary material. It emphasized that there should be an evaluation at all stages, including blood donation, production of HPL, and risk assessment of viral safety. Above all, HPL manufacturers should ensure the quality of PC used in their production, and the HPL manufacturing facilities should meet the standards set by the Good Manufacturing Practice (GMP) protocols.
[the_background] => Until recently, FBS has been the go-to supplement medium for external experimentation to propagate stromal cell-based medicinal products. However, due to its animal-based origins, there are concerns about the immunological and infectious safety of FBS’s use in cell therapy and regenerative medicine. Given such circumstances, HPL is now emerging as the most viable alternative to FBS as it alleviates this concern. HPL-medium also proved to provide better cell expansion with a shorter doubling time in the expansion of mesenchymal stromal cells (MSCs) from various tissues compared to an FBS-medium and does not stimulate tumorigenicity in vivo. Therefore, the role of HPL in biotechnology and cell therapy is predicted to expand. With that, the need for a consensus on quality and safety criteria is crucial. This study reviews and highlights specific measures proposed to achieve this consensus.
[the_sdg_impact] => There have been growing concerns about FBS use in cell culture media, largely due to the biosafety aspect, the global demand, and an ethical standpoint. The FBS market is loosely regulated, and many cases of fraud have occurred. In 2015, GE Healthcare teamed up with a New Zealand-based company to detect the origin countries of FBS. This is crucial as different countries of origin pose different viral risks. Based on UNSDG 9: Industries, Innovation, and Infrastructure, which aims to promote economic growth through innovation, infrastructure, and industrialization, HPL provides an innovative alternative to FBS. It also appears to be more efficient when used in cell expansion comparatively, improving the production of stromal cell-based medicinal products. FBS depends on many factors that can reduce its production; hence, according to UNSDG 12: Responsible Consumption and Production, HPL is a better alternative as its supply is more sustainable in the long term, and it avoids the wastage of precious human blood resources.
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0167779919301519
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[publication_title] => Production and Quality Requirements of Human Platelet Lysate: A Position Statement from the Working Party on Cellular Therapies of the International Society of Blood Transfusion
[journal_title] => Trends in Biotechnology
[publisher] => Elsevier
[year] => January 2020
[subject] => Medical; Biotechnology; Biomedical Engineering
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[post_date] => 2021-08-12 14:40:10
[post_date_gmt] => 2021-08-12 06:40:10
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[post_title] => An Indigenous Tribe’s Attempt to Reinstate Sustainable Development and Adaptation to Climate Change
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[researchers_name] => LIN, Yih-Ren (林益仁)
[researchers_position] => Graduate Institute of Humanities in Medicine, Taipei Medical University, Taiwan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/Indigenous-.png
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[research_footprints] => Alnus formosana; climate change; sustainability; adaptation; resilience; climate action
[graphic_abstract] =>
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[video] =>
[the_novelty] => Western epistemology has always been an integral part of modern society and constantly shapes the deeply-rooted ideology within the global community. Consequently, we have been dismissing the dissemination of knowledge based on different cultural and language entities, especially those of the indigenous people. Hence, this study reinstitutes an alternative mindset by pivoting on the “Millet Ark” initiative, a Tayal community’s millet biodiversity conservative endeavor that effortlessly connects the community, nature, and culture. This “indigeneity retrieval” effort began in 2013 and initiated the realization of the grassroot network involving two of the authors (Pagung and Yih-Ren Lin) and a few members of Taiwan indigenous people and mountain farmers from nine other countries in Bhutan through walking workshops. Inspired and influenced by this experience, Pagung decided to revive long-left millet cultivation in her village. The study assimilated the spirit of the indigenous community, wherein most of the findings were derived using the walking and storytelling culture of indigenous people. The success of Pagung in reinstating Tayal millets in the past five years is evident from the growth of the project from one plot of land to a remarkable landscape of the village, and the millet conservation movement is only continuing to expand by the day.
[the_background] => The main aspiration of this study is to revive the values and practices of the indigenous community of Taiwan, particularly the Tayal ethnic group, via exploring the indigenous resilience, which is so brilliantly elucidated via the “Millet Ark” conservation narration. Indigenous resilience is defined as a dynamic process of cultural and ecological adaptation and alteration in response to climate change that is imperative in ensuring the survival of human and non-human species without losing the ethos of a culture. The main limitation in the study is the possible loss of essence that happens in translating indigenous stories or songs into English or Chinese. To retain the gist of the native stories, the authors tried their best to translate the ideas instead of words and accepted a certain level of untranslatability as the power of the alternative ideology that challenges mainstream which is the very purpose of this study. This study is so uniquely crucial as it is proof that the indigenous practice like Tayal millet foodscape sustained the bio- and cultural diversity, enhanced human-nature connection, and fostered complex adaptive system thinking, which is all we need in facing the climate change issue.
[the_sdg_impact] => An undeniable but relegated truth is that the indigenous people are among the first to face the consequences of climate change due to their co-dependence on nature. The severity of this issue was proven when the special theme of the 7th session of the United Nations Permanent Forum on Indigenous Issue (New York, 2008) was “Climate change, bio-cultural diversity, and livelihoods: the stewardship role of indigenous peoples and new challenges.” Consistent efforts are needed to mitigate the continuous repercussions faced by the indigenous community in the face of climate change, which is why this study sets a precedent in this matter. Thus, this effort upholds not just one but three vital United Nations Sustainable Development Goals (UNSDG); Goal 13: Climate action, Goal 15: Life on land, and Goal 17: Partnership.
[article_url] => https://www.mdpi.com/2071-1050/12/24/10676
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[doi] => https://doi.org/10.3390/su122410676
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[publication_title] => Situating Indigenous Resilience: Climate Change and Tayal’s “Millet Ark” Action in Taiwan
[journal_title] => Sustainability
[publisher] => MDPI
[year] => December 2020
[subject] => Humanities; Biomedical Engineering
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[post_title] => Unknown Roles of Non-hypophysiotropic Gonadotropin-releasing Hormone Neurons Deciphered
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[researchers_name] => OKA, Yoshitaka (岡良隆)
[researchers_position] => Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/08/hypophysiotropic-.png
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[research_footprints] => carassius auratus; corticotropin-releasing hormone; neuropeptide; danio rerio; midbrain tegmentum; neuromodulation; wild type; excitatory postsynaptic potential; vertebrate; fonadotropin releasing hormone; trigeminal nerve; terminal nerve; spinal cord
[graphic_abstract] =>
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[the_novelty] => Non-hypophysiotropic gonadotropin-releasing hormone (GnRH) neurons are commonly found in vertebrates. This review concluded that the non-hypophysiotropic GnRH neurons play an essential role in modulating neural circuits, depending on the internal condition or the external environment. They are involved in regulating major activities, such as behavioral motivation, food intake, and sensory reception, rather than just reproduction. For future studies, the authors planned for in vivo studies to investigate the timing and functions of the non-hypophysiotropic release of GnRH and cotransmitter. Furthermore, they aim to study the significance of non-hypophysiotropic neurons projecting to broad brain regions release GnRH and other cotransmitter(s).
[the_background] => Neuromodulation is the function to modulate neural activities in regions to which the releasing hormone neurons project. In vitro studies of the brain showed that non-hypophysiotropic GnRHs were neuromodulating various sensory processing pathways. However, the functions of non-hypophysiotropic GnRH neurons in the daily activities of organisms were unclear. To understand those functions, this review summarized the anatomical and physiological properties of non-hypophysiotropic GnRH neurons and discussed their roles in vertebrates, mainly teleosts. The summary establishes an in-depth understanding of non-hypophysiotropic GnRH neurons. The analysis enhances the literature on vertebrates’ anatomy and physiology.
[the_sdg_impact] => New findings and reports related to vertebrates’ anatomy and physiology are valuable, especially for medicine and veterinary. The knowledge would contribute to improving the well-being of most living beings. Therefore, the output of this review helps to achieve UNSDG 14: Life Below Water and UNSDG 15: Life on Land by emphasizing the sustainability of vertebrates.
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0138-y
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[publication_title] => Multiple functions of non-hypophysiotropic gonadotropin releasing hormone neurons in vertebrates
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => July 2019
[subject] => Zoology; Biological Sciences
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[post_title] => Method Used by Dicyemid in Locating New Hosts Revealed by Gene Expression Profiles
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[research_footprints] => dopamine beta hydroxylase; gene ontology; gamma-aminobutyric acid; G-protein-coupled receptors
[graphic_abstract] =>
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[video] =>
[the_novelty] => To date, several aspects of dicyemid mesozoans’ lifecycle remain uncertain. In this study, the gene expression profiles characterization conducted at different life stages reveals new information of various biological processes of the organism. More genes were expressed in free-living infusoriform larvae when compared across the four life-cycle stages, primarily due to its need to search for new hosts in the open ocean. Neurotransmitters and neuropeptides, as well as short cilia, served as sensory functions for detecting new hosts. With that said, the experimental techniques employed in this study would be beneficial to other research on simple organisms and understanding their biological mechanisms.
[the_background] => Despite having a bare 30-cell composition as an adult, the life-cycle of dicyemid mesozoans has yet to be fully understood. It is known that there are four stages in the entire lifecycle of dicyemids, namely nematogens, vermiform larvae, rhombogens, and infusoriform larvae. Since obtaining samples of infusoriform larvae from the ocean has been a great challenge, researchers were unable to grasp how the larvae search for new hosts. Besides that, the infusoriform larvae’s sensory mechanism is obscure since they do not have a nervous system. By characterizing the gene expression profiles of the four stages of Dicyema japonicum, the biological functions of the dicyemid stages and potential sensory functions for detecting new hosts were discussed in detail in this study. The study of gene expression profiles showed great potential in understanding the significance of different life-cycle stages of organisms.
[the_sdg_impact] => Dicyemida is a tiny parasite that lives in the renal appendages of cephalopods like squid, octopus, cuttlefish, and many more. Since these aquatic animals are crucial to maintain the balance of the marine ecosystem and serve as food sources, it is vital for the infection mechanism of the parasites they carry and the effects on the host to be clearly understood. Generally, research on parasites is challenging due to their simplified morphology and complex lifecycles. Therefore, the techniques adopted in this study could be useful in facilitating further exploration of parasitism in other organisms. Indirectly, it contributes to the realization of UN SDG 9: Industries, Innovation & Infrastructure by supporting technology development, research, and innovation.
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0146-y
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[publication_title] => Gene expression profiles of dicyemid life-cycle stages may explain how dispersing larvae locate new hosts
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => November 2019
[subject] => Zoology; Biological Sciences
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[post_date] => 2021-08-07 11:21:48
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[post_title] => Role of Self-marker Proteins in Sea Pineapple’s Immune System
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[researchers_name] => MATSUMOTO, Midori (松本緑)
[researchers_position] => Bioscience and Informatics, Keio University, Japan
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[research_footprints] => room temperature; membrane protein; coomassie; phenol oxidase; botryllus schlosseri; monoclonal antibody; ciona intestinalis; artificial seawater; phosphate-buffered saline; halocynthia roretzi; polyvinylidene difluoride; bovine serum albumin; allorecognition; hemocyte; isoelectric focusing; periodic acid–schiff; immune system; major histocompatibility complex; natural killer; Ascidian
[graphic_abstract] =>
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[video] =>
[the_novelty] => This study proposed a potential novel type of self-marker protein involved in the self and non-self-cells distinguishing mechanism in Halocynthia roretzi (sea pineapple) hemocytes. By examining the contact reactions (CR) of sea pineapple hemocytes, the membrane proteins (HrSMLP1) have been identified as responsible for the hemocyte’s role in allorecognition. A monoclonal antibody (mAb11B16B10) was synthesized to induce CR in hemocytes. As a result, phenol oxidase (PO) was released, which served as an important indicator to identify the self-marker proteins. The findings provided comprehensive insights into the allorecognition mechanism of invertebrate H. roretzi.
[the_background] => Allorecognition is part of the immune response of an organism to distinguish its tissues from those of another individual. There are three commonly recognized allorecognition types in ascidians, self-incompatibility, fusion/non-fusion reactions, and contact reactions (CRs). Past studies have successfully classified hemocytes in sea pineapples (H. roretzi) to be able to differentiate into nine different cell types, among which were due to CR. Thus, this study hypothesized that self-marker molecules are present on the surface of hemocyte membranes, and that PO-inducing levels change in response to changes in the state of self-marker molecules. However, there is a lack of evidence in terms of genetic data to support such claims to date. Therefore, this study investigates the allorecognition mechanism of H. roretzi by exploring the hemocyte structure and trigger. The findings serve as good references to understand the evolution of the immune system and the roles of self-marker proteins in organisms.
[the_sdg_impact] => Comprehensive knowledge of organisms and their biological mechanisms is essential to maintain the balance and enhance the natural ecosystem. Understanding the immune system that aids the evolution and survival of vertebrates and invertebrates brings conservatory measures a step closer. The findings of this study, which revealed new information of biomarkers vital to self and non-self-cells distinguishing mechanisms in marine organisms, such as H. roretzi, would potentially contribute to the realization of UNSDG 14: Life Below Water.
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0149-8
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[publication_title] => A self-marker-like protein governs hemocyte allorecognition in Halocynthia roretzi
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => December 2019
[subject] => Zoology; Bioscience and Informatics
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[post_date] => 2021-08-03 13:34:53
[post_date_gmt] => 2021-08-03 05:34:53
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[post_title] => Crucial Mediating Mechanism in Color Vision of Butterfly via Heterologous Action Spectroscopy
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[researchers_name] => TERAKITA, Akihisa (寺北明久)
[researchers_position] => Graduate School of Science, Osaka City University, Japan
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[research_footprints] => visual pigment; absorption spectra; glutamic acid; convergent evolution; spectroscopy; chromophore; rhodopsin; light-emitting diode; color vision; ;amino acid residue; papilio xuthus; G protein-coupled receptors
[graphic_abstract] =>
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[video] =>
[the_novelty] => For insects and other invertebrates, the spectral tuning mechanism of their color vision is largely unknown. To shed some light on this matter, this study adopted a methodology previously developed by the research group known as heterologous action spectroscopy. This technique revealed that two amino acids at positions 116 and 120 in helix III of butterfly Papilio xuthus long-wavelength-sensitive (LWS) opsins play a significant role in its spectral tuning mechanism. The helix III yielded a difference of about 15 nm in the wavelength of absorption maxima of PxRh1 and PxRh3 LWS opsins. With such detailed results, heterologous action spectroscopy has proven to be a promising method for examining invertebrates' visual systems, and its application could potentially be extended to understand other invertebrates.
[the_background] => Spectral tuning in visual systems of organisms is a crucial ability to sense a wider range of visible light wavelengths. This ability is closely related to opsins, a group of proteins made light-sensitive via the chromophore retinal found in photoreceptor cells of the retina. Past studies have indicated that distinct spectral tuning mechanisms are employed in the visual opsins of vertebrates and invertebrates. However, the tuning mechanism of invertebrates remains unclear due to the challenges in obtaining purified recombinant pigments. In fact, at present, there is no adsorption spectrum of the butterfly color-opsin available too. Therefore, this study adopts the heterologous action spectroscopy technique to obtain the absorption spectra of wild type PxRh1 and PxRh3 LWS opsins which share 81.7% amino acids. Besides confirming a spectral tuning mechanism different from primate LWS opsins, this method also reveals the potential spectral tuning mechanism in butterfly LWS opsins.
[the_sdg_impact] => Efficient research methodologies and equipment are the keys to the advancement of scientific research. This study proved the usefulness of heterologous action spectroscopy in understanding the visual system of invertebrates, which was initially challenging. Such development in research techniques does not just provide in-depth knowledge of previously unknown biological mechanisms of invertebrates, but also models an innovative future for scientific research methodologies. (UNSDG 9: Industry, innovation and infrastructure)
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0150-2
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[publication_title] => Spectral tuning mediated by helix III in butterfly long wavelength-sensitive visual opsins revealed by heterologous action spectroscopy
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => December 2019
[subject] => Zoology; Entomology
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[post_date] => 2021-07-14 21:09:58
[post_date_gmt] => 2021-07-14 13:09:58
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[post_title] => Control Flying Insect Outbreaks by Manipulating Light Wavelengths and Understanding Weather Conditions
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[researchers_name] => NISHINO, Hiroshi (西野浩史)
[researchers_position] => Research Institute for Electronic Science, Hokkaido University, Japan
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[research_footprints] => gypsy moth; oak silkmoth; chafer; fluorescent light; light-emitting diode (LED); light trap; meteorological factors; subarctic region
[graphic_abstract] =>
[video] =>
[the_novelty] => The novelty of this study is attributed to its environmentally friendly method of controlling insect activity within public spaces in sub-arctic climate regions. An extensive field survey based in Hokkaido found that different wavelengths of light and weather conditions affected insect activity. In specific, aquatic insects and winged ants were drawn to broadband light wavelengths while moths and beetles were attracted to short light wavelengths. An examination of weather parameters among Gypsy moths and Japanese oak silkmoths revealed that Gypsy moths were positively correlated with the highest ambient temperature on the catch day. Especially, suitable range (22-24 ˚C) of dusk temperature promoted their synchronous mass flight. 380 nm LED, which is more cost-effective and energy-efficient than UV LEDs (<370 nm), was sufficient for capturing both moth species.
[the_background] => Insect outbreaks not only affect agriculture but can also be an aesthetically and practically unpleasant experience, especially within commercial spaces. Past studies neither tackled the influence of weather factors on insect activity nor were they applicable to commercial settings. Therefore, this study performed a 4-year long insect survey using light traps to observe different species of insects. The study then manipulated LED light wavelengths to observe light orientation among different species, besides weather variables. Findings from this study serve as an environmentally-friendly guide to manage insect outbreaks.
[the_sdg_impact] => The United States Department of Agriculture highlights the influence of climate change on forest insect outbreaks. Therefore, there is a need for sustainable measures that incorporate the climate to curb insect outbreaks without entirely relying on it. As proposed by the United Nations’ Sustainable Development Goal 15, specifically target 9, this study successfully integrates light technology and weather factors to curb insect outbreaks in local commercial spaces without known damage to the environment.
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-020-00163-7
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/07/insects-1.jpg
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[publication_title] => Management of flying insects on expressways through an academic-industrial collaboration: evaluation of the effect of light wavelengths and meteorological factors on insect attraction
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => November 2020
[subject] => Zoology; Entomology; Electronic Science
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[post_date] => 2021-07-07 19:00:16
[post_date_gmt] => 2021-07-07 11:00:16
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[post_title] => EMP-Proof Detector for Laser Nuclear Physics
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[researchers_name] => HU, Po
[researchers_position] => School of Phys. Sci. and Tech, ShanghaiTech University, China
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[researchers_name_2] => FU, Changbo
[researchers_position_2] => Institute of Modern Physics, Fudan University, China
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[research_footprints] => nuclear reaction; coulomb explosion; high energy; electromagnetic pulse; radiation detection; numerical aperture; nuclear physics; photomultiplier tubes
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/07/NST_Article-10_V0.jpg
[video] =>
[the_novelty] => Would it be possible for a detector to accurately detect weak nuclear reactions signal in the HIL-induced plasma environments without being affected by the induced high electromagnetic pulse (EMP)? This study has developed a gated fiber detector (GFD) which was meant for that purpose. The main structure of the GFD included a reflective layer, a scintillating layer, a vacuum sealing glass window, a photon coupling cone, a fiber, and a gated photomultiplier tube (gPMT). Based on the results from numerical simulation, the optimal light-collecting efficiency was achieved in the development, which maximized the number of photons to be coupled by fiber and then transferred to a light detector (i.e., gPMT) located far away from the EMP source. Online tests confirmed that the detector was performing up to expectation and its response time was as short as 70 ns. Future optimization could be explored by collecting feedback from actual utilization.
[the_background] => The demand for studying nuclear reactions in laser-induced high-temperature plasma environments is increasing. Nevertheless, extremely high EMPs are commonly induced in such environments, thus crippling the functions of many traditional detectors. To overcome these complications caused by EMPs, this study has designed a detector that potentially avoids the effect of EMPs, yet still, be capable of identifying a single event of nuclear reaction products. By overcoming the EMPs, the detector was feasible to be utilized as time-of-flight (TOF) detector in high-intensity laser nuclear physics experiments. Such a development would help to achieve the goals of various studies related to laser nuclear physics.
[the_sdg_impact] => The potential of laser-induced nuclear physics has attracted a considerable amount of attention. With continuous progress and development, it is believed to be a window for new technologies in multidisciplinary. Apart from eliminating the hurdles caused by EMPs, this development also creates opportunities to widen the direction of studies related to laser nuclear physics. Hence, by enhancing the progress in peacefully using laser and nuclear techniques, this study materialized the UN SDG Goal 9: Industry, Innovation & Infrastructure.
[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00898-8
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[publication_title] => Development of gated fiber detectors for laser-induced strong electromagnetic pulse environments
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => June 2021
[subject] => Engineering; Applied Physics
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[post_title] => New Technique for Precise Measurement of Nuclei’s Angular Distribution
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[researchers_position] => China Institute of Atomic Energy, China
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/07/Nuclei4.png
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[researchers_name_2] => GUO, Bing
[researchers_position_2] => China Institute of Atomic Energy, China
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[research_footprints] => exotic nuclei; halo nucleus; coulomb barrier; nuclear physics; heavy-ion; elastic scattering; time of flight
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/07/NST_Article-9_V1_EN-1-1-scaled.jpg
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[the_novelty] => Is it feasible to perform measurements at accelerators using the isotope separator on-line (ISOL) technique? This study confirmed the feasibility by performing the first-ever proof-of-principle experiment with a post-accelerated 23Na beam (using the ISOL technique). Such was primarily made possible by measuring the angular distribution of 23Na + 40Ca elastic scattering. The angular distribution measured showed consistency with the high-precision Q3D magnetic spectrograph measurements (using non-ISOL beam). Thus, this breakthrough enables researchers to explore the potential properties of non-stable Na isotopes by measuring the angular distribution of 21,22Na + 40Ca elastic scattering.
[the_background] => A nuclear drip line is a boundary delimiting the zone beyond which atomic nuclei decay by the emission of a proton or neutron. Nuclei with short life, unstable, radioactive are known to be exotic when they develop unusual structures. Meanwhile, the reaction dynamics of light exotic nuclei near the drip line have been getting significant attention, especially from the low-energy nuclear physics community. Several important properties of exotic nuclei include the size and surface diffusiveness which can be determined using elastic scattering. Such measurements were commonly performed at accelerators using the projectile fragmentation technique. However, reported studies that applied the ISOL technique for the same purpose were rare. By presenting the above-mentioned proof-of-principle experiment conducted at the Beijing Radioactive Ion Beam Facility (BRIF), the potential and feasibility of the technique were proven in this study. Furthermore, the output of this research gave validation for scientists to apply the ISOL technique in relevant investigations of the reaction dynamics of exotic nuclei.
[the_sdg_impact] => The properties of exotic nuclei can become very different from those of stable isotopes. That implies the existence of unexplored applications of exotic nuclei in nuclear technology. By introducing a highly reliable technique for the characterization of nuclei, this study established a strong foundation for future studies of exotic nuclei. Hence, it contributes to the realization of UNSDG 9: Industries, Innovation & Infrastructure by supporting future research related to nuclear science.
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[publisher] => Springer Nature
[year] => May 2021
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[post_title] => Charge Resolution in the Isochronous Mass Spectrometry
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[research_footprints] => isochronous mass spectrometry; charge resolution; signal amplitude; micro-channel plate
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[the_novelty] => The mass measurements of short-lived nuclei require advanced facilities as well as high-level knowledge and skills. This study reports a new analysis method for isochronous mass spectrometry (IMS) experiments that led to significant improvements in charge resolution for ions. By considering the signal amplitudes, detection efficiencies, and the number of stored ions in the heavy-ion storage ring, ion pairs with nearly identical mass-to-charge (m/q) ratios can be resolved in terms of their revolution times. The new method enabled a complete resolution of 34Ar and 51Co in this study. Additionally, a consistent mass excess of 51Co was determined.
[the_background] => IMS of heavy-ion storage rings is a powerful technique to measure the mass of short-lived nuclei. Its working principle relies highly on its ability to measure the revolution times of ions precisely. Nonetheless, there was a limitation in the measurements for pairs of ion species with nearly identical m/q ratios. To address this, the researchers analyzed the amplitudes of the timing signals from the detector based on the emission of secondary electrons in a previous study. The introduction of a new analysis method was able to deduce revolution times with differences as low as 1.8 ps. This led to a higher charge resolution, enabling the complete resolution of 34Ar and 51Co (A/Z = 17/9). The new analysis method would facilitate the progress of other atomic and nuclear physics experiments using similar types of detectors.
[the_sdg_impact] => Nuclear technologies are useful to meet some of the fundamental needs of modern daily life. These include access to energy and proper medical care, food production, water resources management, and many more. Having effective methods to study exotic short-lived nuclei could open up endless possibilities for further exploring nuclear technology applications. The new analysis method reported by this study has enabled accurate characterizations of short-lived nuclei. Its contributions, aligned with UNSDG 9: Industries, Innovation & Infrastructure, promises the enhancement of scientific research necessary for upgrading existing and future nuclear technological capabilities.
[article_url] => https://link.springer.com/article/10.1007%2Fs41365-021-00876-0
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[publication_title] => Charge resolution in the isochronous mass spectrometry and the mass of 51Co
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => April 2021
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[post_title] => A Novel Annotation-free Whole-slide Classification of Lung Cancer Pathologies Classification
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[researchers_name] => CHEN, Cheng-Yu
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[research_footprints] => pathology; hematoxylin and eosin; unified memory; deep learning; recurrent neural network; Deep neural networks; squamous cell carcinoma; convolutional neural networks; adenocarcinoma; lung cancer; support vector; machine; neural network; multiple-instance learning; artificial intelligence; radial basis function
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[the_novelty] => This study highlights the development of a whole slide training method to train convolutional neural network (CNN) for pathological classification of lung cancers. This method is superior to the existing digital diagnosis methods, such as the multiple-instance learning (MIL) method. A total of 7003 slides were gathered, consisting of 2039 cases of non-cancer, 3876 of adenocarcinoma, and 1088 cases of squamous carcinoma. The slides were randomly assigned for training, validation, and testing purposes. The slides were then subjected to different model performance testing to study various parameters in image analysis in lung cancer. In this study, whole slide imaging (WSI) used recorded superior results to MIL in terms of visualization, small lesion diagnosis, image resolution (despite the impact of data size), and memory consumption. Provided that there’s a limitation on host memory when training larger images on CNN, future research to identify a more memory-efficient algorithm will further optimize the model in the digital diagnosis of diseases.
[the_background] => CNN is a deep neural network in artificial intelligence (AI) designed for image analysis. It is a deep learning algorithm representing image input, extracts the importance of every bit of the image (each neuron), and distinguishes one image from another. In nonsmall-cell lung cancer (NSCLC), proper pathological diagnosis to differentiate between adenocarcinoma and squamous cell carcinoma presents a challenge, as the difference in pathological features between them is subtle. Hence, CNN has been the primary method used in image recognition in distinguishing these two histologically different NSCLC subtypes. Despite its success in tumor type identification and classification, the path-based CNN method demands substantial annotations on the slides by experienced pathologists. MIL, another technique employed to reduce the annotation burden, is subject to incorrect selection of patches for diagnosis or classification in early training, leading to compromise in the model’s performance. To overcome the limitations of existing methods, this study proposes using WSI to train CNN utilizing slide-level labels, the outcome of which intends to prove the superiority of this approach.
[the_sdg_impact] => Since the introduction of WSI in 1991, it has achieved remarkable growth in technology and is recognized in various applications in pathological diagnosis. The approval of the US FDA to a WSI system for primary surgical pathology diagnosis in 2017 has paved the way for the acceptance of this technology for broader medical applications. Given that the health demand is increasing by the day, non-laborious, highly efficient technology is snatching importance in enhancing diagnosis and disease classification processes. Thus, the utilization of WSI to train CNN in the diagnosis and classification of lung cancer becomes imminently crucial and contributes to the realization of United Nations Sustainable Development Goal (UNSDG) 3, good health and well-being.
[article_url] => https://www.nature.com/articles/s41467-021-21467-y
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[journal_title] => Nature Communications
[publisher] => Springer Nature
[year] => February 2021
[subject] => Medical; Radiology
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[post_title] => COVID-19 Infection Risk in Cancer Patients
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[researchers_name] => LIN, Liang-Tzung
[researchers_position] => Department of Microbiology and Immunology, College of Medicine, Taipei Medical University, Taiwan
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[research_footprints] => acute respiratory distress syndrome; The Cancer Genome Atlas; coronavirus disease; innate immunity; cathepsin L; angiotensin-converting enzyme 2; Gene Expression Omnibus; cancer patient; covid19
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[the_novelty] => This study investigated the intricate relationship between cancers, anti-cancer treatments, and SARS-CoV-2 infection to understand possible modifications needed for the clinical management of cancer patients. Large-scale genome-wide transcriptional analysis revealed that RNA expression of three significant genes responsible for SARS-CoV-2 entry into cells, including ACE2, TMPRSS2, and CTSL, were upregulated in different cancer tissues assessed. These viral entry genes were also upregulated in male patients and those who smoke and transiently increased during radiotherapy. In addition, chemotherapy and radiotherapy both transiently dysregulated the immune system in cancer patients. These alterations possibly predisposed this cohort to higher susceptibility and severity of COVID-19. Findings from this study urge further investigation of the complex relationship between cancers and COVID-19 to optimize treatment strategies for both diseases in cancer patients.
[the_background] => Similar to the closely related SARS-CoV, SARS-CoV-2, the novel coronavirus responsible for COVID-19 mainly relies on the angiotensin-converting enzyme 2 (ACE2) type I membrane protein, host cell serine protease transmembrane protease serine 2 (TMPRSS2), and endosomal cysteine protease cathepsin L (CTSL) to enter target cells. The expression of these proteins allows SARS-CoV-2 infection, which then triggers host antiviral response. However, SARS-CoV-2 can also deregulate the immune system, leading to a hyperinflammatory reaction with cytokine over-production that contributes to COVID-19 progression and severity. Based on the increased prevalence and severity of COVID-19 in cancer patients reported in multiple previous cohorts, this study aimed to examine the expression of SARS-CoV-2 entry genes in various cancer tissues and the effect of radiotherapy and chemotherapy on these viral entry genes and host immune responses.
[the_sdg_impact] => COVID-19 pandemic has caused over 150 million cases and approximately 3 million deaths worldwide as of mid-2021. Cancer patients are four times more likely to be infected by SARS-CoV-2 than the general population, making it a big concern to both patients and oncologists. Hence, identifying risk factors of COVID-19 in cancer patients is vital to reducing morbidity and mortality in this group. In line with that, the findings of this study are imperative to guide clinicians and oncologists on the management of cancers during the COVID-19 pandemic to alleviate potential complications that could impose a huge health burden on the global health system. Ideally, such an endeavor is crucial to uphold the UNSGD 3: Good health and well-being, aiming to improve global health and, thus, global public health. With the pandemic being the current health emergency globally, every effort at improving its management becomes an integral part of fighting the battle.
[article_url] => https://www.nature.com/articles/s41598-021-83366-y
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[journal_title] => Scientific Reports
[publisher] => Springer Nature
[year] => February 2021
[subject] => Medical; Microbiology; Immunology
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[post_date] => 2021-06-21 10:28:31
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[post_title] => Monte Carlo Simulations Made Better with New CMGC Model
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[researchers_name] => WANG, Xin (王鑫)
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[researchers_name_2] => LI, Junli (李君利)
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[research_footprints] => footnote; computer-aided design; boundary representation; constructive solid geometry; graphical user interface; Monte Carlo; CAD; geometry converter; complete solid decomposition
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/06/NST_Article-02-1.jpg
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[the_novelty] => This study elaborates the algorithms, implementations, and applications of a new computer-aided design (CAD) model to Monte Carlo geometry converter (CMGC). This newly developed conversion code promises highly efficient Monte Carlo simulations by generating appropriate constructive solid geometry (CSG) representation. As a result, this automatic conversion can produce heuristic strategies for solid splitting, reduce the time taken for particle transporting, provide low relative volume error, and has a friendly graphical user interface. At the end of the CMGC conversion, the converted models show high accuracy and improved efficiency in particle transport calculations.
[the_background] => The computer-aided design (CAD) model to Monte Carlo geometry conversion is recognized as the most effective automatic conversion method compared to the conventional boundary representation model. Recent researches have been heavily focused on improving the efficiency of large-scale and detailed Monte Carlo modeling. Among the areas of focus are to reduce manual work, increase conversion speed, and improve conversion accuracy. This study aims to provide an in-depth analysis of a new conversion method and demonstrate its improved Monte Carlo simulation efficiency.
[the_sdg_impact] => The Monte Carlo methods are very common and preferred when designing sophisticated nuclear systems due to their capability of dealing with complex problems with high accuracy. Radiation technology and computational medicine physics, among other fields, are known to benefit from an efficient and safe interface such as the CMGC model mentioned in this study. Therefore, the detailed description in this study would serve as a good reference for future infrastructure upgrading with increased resource-use efficiency and accuracy, as proposed in the 9th UN Sustainable Development Goal: Industry, Innovation and Infrastructure.
[article_url] => https://link.springer.com/article/10.1007/s41365-020-00793-8
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[publication_title] => CMGC: a CAD to Monte Carlo geometry conversion code
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[post_title] => Improved Version of Angle-resolved Photoemission Spectroscopy (ARPES) Makes In-situ Characterization of the Fine Electronic Structure of Condensed Matter Possible
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[researchers_position_2] => State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), China
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[research_footprints] => reflection high-energy electron diffraction; angle-resolved photoemission spectroscopy; molecular beam epitaxy; scanning tunneling microscopy; light source; X-ray diffraction; photoemission spectroscopy; low-energy; electron diffraction; ultrahigh vacuum; high harmonic generation; synchrotron radiation; electronic structure; band theory; second harmonic generation; Shanghai Synchrotron Radiation Facility
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[the_novelty] => To meet the high requirements of sophisticated studies in condensed matter physics, this research has successfully designed and constructed a more advanced synchrotron angle-resolved photoemission spectroscopy (ARPES) beamline (BL03U) and an endstation at the Shanghai Synchrotron Radiation Facility (SSRF). The BL03U endstation consists of an ARPES system, a load-lock chamber, an oxide molecular beam epitaxy (OMBE) system, a scanning tunneling microscopy (STM) system, and a UFO-like transfer chamber. The beam spot produced by the ARPES system is as fine as 7.5 um (V) × 67 um (H) with the fundamental photon range of 7 to 165 eV. Photoemission with an energy resolution of 2.67 meV (at 21.2 eV photon energy) was achieved by the newly developed ARPES system. By equipping the ARPES system with a six-axis cryogenic sample manipulator (minimum temperature of 7 K), the BL03U endstation provides an essential platform to carry out in-situ characterization of the electronic structure of condensed matter. Such a development has demonstrated the versatility of an ARPES endstation to be enhanced to support future studies in condensed matter physics.
[the_background] => Conventional ARPES is well-known for its capability in characterizing the electronic properties of correlated materials and the electronic structure of correlated electron systems. Nonetheless, conventional ARPES faced several bottlenecks when it was applied in the recent development of quantum materials which has higher characterization requirements in terms of photon energy, flux, and beam spot. Besides that, quantum material samples with a flat surface along the desired crystalline orientation were difficult to be prepared for characterization under ARPES. To address these limitations, a more superior ARPES endstation has been developed by this study. Furthermore, with the OMBE system and connected growth chamber, epitaxial growth techniques are able to be applied to realize in-situ ARPES measurements without the need for tedious sample preparation. By having the state-of-the-art features, this facility will boost the advancement of studies in condensed matter physics.
[the_sdg_impact] => The improvement of ARPES will help condensed matter physicists to better understand the behavior of more exotic condensed phases include the superconducting phase exhibited by certain materials at low temperature. More experiments can be conducted using the improved facility to measure various material properties, and by applying the physical laws of quantum mechanics, electromagnetism, statistical mechanics, and other theories to develop mathematical models. Such innovative facility is a great contribution to the research infrastructure that supporting and aligning to the UNSDG 9: Industries, Innovation & Infrastructure.
[article_url] => https://link.springer.com/article/10.1007/s41365-021-00858-2
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/06/ARPES-3.jpg
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[doi] => https://doi.org/10.1007/s41365-021-00858-2
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[publication_title] => High-resolution ARPES endstation for in situ electronic structure investigations at SSRF
[journal_title] => Nuclear Science and Techniques
[publisher] => Springer Nature
[year] => March 2021
[subject] => Engineering; Applied Physics
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[post_date] => 2021-05-27 20:18:15
[post_date_gmt] => 2021-05-27 12:18:15
[post_content] =>
[post_title] => How do the Elderly Community Obtain Health Information?
[post_excerpt] =>
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[post_name] => how-do-the-elderly-community-obtain-health-information
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[researchers_name] => AHMAD, Normawati
[researchers_position] => Institute for Health Behavioural Research, National Institutes of Health, Ministry of Health, Malaysia.
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[research_footprints] => elderly; daily life; internet access; health information
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/g46d.png
[video] =>
[the_novelty] => This study provides evidence of the increase in digital dependency, usage, and literacy among the elderly community when seeking health information. The most common information searched online is on diseases and disease-related nutrition advice. Consistent with previous findings, elderly people prefer using the internet to search for health information because of accessibility and convenience. However, the amount of information presented can be overwhelming with risks of misinformation if they are uncertain of how to identify the right source. Therefore, health information providers should consider the internet as a source of knowledge dissemination and support the elderly population by directing them to official channels to seek information. Such behavioral understanding could potentially be expanded into monitoring and surveillance of the aged community.
[the_background] => The ‘Dr. Google’ phenomenon is widely observed with the growing internet accessibility. Apart from encouraging social interaction and collaboration, the internet has become a reliable channel for many to continuously learning about their health and seek advice to improve their conditions. As the elderly community is among those most prone to a range of diseases and illnesses, seeking quick and comprehensive information on their health becomes the priority when using the internet. Having said that, little is known of the Malaysian elderly behavior when it comes to internet dependency and online health information-seeking habits. Therefore, this study chose to profile residents of 23 Elderly Activity Centres across Malaysia to understand the online health information-seeking pattern of the elderly.
[the_sdg_impact] => Graceful and healthy aging could be supported with the right tools and systems in place. With health-related information being shared openly and rapidly on many online platforms, knowledge accessibility has certainly improved over the years. In order to protect and support the elderly population in having access to such valuable information and promote lifelong learning, health staff should encourage digital health literacy for older adults as foundations for learning and decision-making (SDG 4: Quality education). With that, the elderly community would not be left out in terms of accessing information on disease prevention, treatment, and rehabilitation to maintain their health and independence (SDG 3: Good health and well-being). However, to work on the mentioned areas, health information providers and policymakers should first understand the digital usage patterns and behaviors of the elderly community. The data offered by this study would be useful to design a more efficient and effective health information dissemination medium.
[article_url] => https://doi.org/10.36713/epra4422
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/elderly-.jpg
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[doi] => https://doi.org/10.36713/epra4422
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[publication_title] => USAGE OF INTERNET FOR HEALTH INFORMATION SEEKING AMONG ELDERLY IN MALAYSIA
[journal_title] => EPRA International Journal of Multidisciplinary Research (IJMR)
[publisher] => EPRA International Journal of Multidisciplinary Research (IJMR)
[year] => May 2020
[subject] => Social Science; Humanities
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[post_date] => 2021-05-27 20:03:07
[post_date_gmt] => 2021-05-27 12:03:07
[post_content] =>
[post_title] => Understanding Diabetic Patients’ Perception towards Conventional and Herbal Medicine
[post_excerpt] =>
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[post_name] => understanding-diabetic-patients-perception-towards-conventional-and-herbal-medicine
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[researchers_name] => ITHNAIN, Norbaidurah
[researchers_position] => Institute for Health Behavioral Research, National Institute of Health Ministry of Health, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/diabetic-.png
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[research_footprints] => conventional medicine; diabetes mellitus; qualitative study; patients; diabetes; herbal medicine; adverse effect; vascular disease; drug interaction
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Graphical-Norbaidurah.png
[video] =>
[the_novelty] => The findings of this study contribute to a regional understanding of how diabetic patients manage their medications and why they choose to opt for herbal medicine instead of relying on clinic prescription. Focused mainly on patients undergoing treatment for Type 2 Diabetic Mellitus (T2DM), it was found that these patients are more inclined to incorporate herbal medicine to complement their conventional treatment regimen. Some have even chosen to alter the dosage and consumption timing of conventional medication to cater to their herbal medicine consumption timing, while some even consider quitting their clinical prescription and relying entirely on herbal treatment. These decisions result from a lack of confidence towards the effectiveness of synthetic drugs, their side effects, and the influence of family and friends. By understanding the patient perception towards conventional and herbal medicine, healthcare providers and policymakers could improve diabetes management to ensure medication safety.
[the_background] => Living in a multi-cultured society and growing preference towards natural products, it is becoming challenging for healthcare personnel to restrict their patients from seeking alternative treatment. The long-term reliance on existing synthetic drugs, slow observable results, and negative side effects have led more T2DM patients to choose herbal medicines over conventional medicine. At present, there are limited qualitative research data available that elaborates the reasons for what triggers such choices among patients. Therefore, this study intends to generate a detailed understanding of the perception, beliefs, and values of the T2DM patients in deciding their preferred treatment. With this knowledge, pharmacists and doctors could cater their medical advice to meet the needs and beliefs of their patients accordingly.
[the_sdg_impact] => The rate at which people are being diagnosed with T2DM is alarming; even more concerning is the attitude of these patients towards managing their conditions post-diagnosis. Diabetes control is part of the UNSDG 3, Good health and well-being, target, to reduce premature mortality and disabilities due to non-communicable diseases by 2030. To combat this global epidemic, multisectoral population-based research is crucial to prevent and manage this disease. This study allows healthcare providers and policymakers to understand patients’ sentiment towards the treatment regimen to improve the monitoring and educating process.
[article_url] => http://www.ccsenet.org/journal/index.php/gjhs/article/view/0/43530
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/diabetic.jpg
[podcast] => https://iesresearch.solutions/wp-content/uploads/2021/05/Herbal_9490655_1630980922.mp3
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[doi] => https://doi.org/10.5539/gjhs.v12n10p122
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[publication_title] => Perception of Conventional Medicine and Herbal Medicine Usage Amongst Diabetic Patients: A Qualitative Study in Negeri Sembilan, Malaysia
[journal_title] => Global Journal of Health Science
[publisher] => Canadian Center of Science and Education
[year] => August 2020
[subject] => Medical; Diabetes
)
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[post_date] => 2021-05-27 19:41:15
[post_date_gmt] => 2021-05-27 11:41:15
[post_content] =>
[post_title] => How are Patients Responding to Health Education Services Provided in Clinics?
[post_excerpt] =>
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[post_name] => how-are-patients-responding-to-health-education-services-provided-in-clinics
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[researchers_name] => JAAFAR, Norrafizah
[researchers_position] => Institute for Health Behavioural Research, Ministry of Health, Malaysia
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[research_footprints] => healthcare system; health education; non-communicable diseases; ;thematic analysis; health care; liaison officers
[graphic_abstract] =>
[video] =>
[the_novelty] => This study delineates patients’ experience in receiving health education services given by healthcare providers (HCPs) in clinics that have adopted the Enhanced Primary Health Care (EnPHC) initiative. As a whole, patients recognize the intention of including such intervention components and are willing to engage with HCPs in educating themselves to cope with their illnesses. However, they wish to have certain concerns and challenges to be addressed before fully reaping the benefits of the service provided. Among the factors identified to have caused patient scepticism towards receiving health education at secondary triage are the prolonged waiting period, lack of privacy at waiting area, repetitive message delivery, interpersonal relationship between patient and the health educators and the confidence in their credibility. Therefore, to ensure the effectiveness of the EnPHC initiative in educating the patients and supporting them in coping with their medical conditions, these feedbacks should be considered and acted upon by clinic management and health educators.
[the_background] => The introduction of the Enhanced Primary Health Care (EnPHC) initiative by the Malaysian government is to assist patients in coping with the complexity of living with non-communicable diseases (NCDs). With patient-centric service delivery as the primary motive, providing comprehensive health education and increasing patient awareness are identified as key components for the successful implementation of the EnPHC initiative. Although the intentions of including these components are clearly to benefit the patients, there is little knowledge of how the patients are perceiving such changes. Therefore, this study aims to understand patient perception and experience as recipients of health education at secondary triage. These feedbacks could then be used by the clinic management, health educators, and policymakers to improve the service delivery mechanism.
[the_sdg_impact] => According to the World Health Organization (WHO), preventing premature deaths and disabilities from non-communicable diseases (NCDs) is possible, cost-effective, and necessary for human and economic development (SDG 3: Good health and well-being). As the Malaysian healthcare system is currently undergoing transformation to improve the country’s essential healthcare service delivery, equipping the patients with sufficient knowledge about their illnesses and coping mechanism is considered as one of the most cost-effective interventions. The feedback gathered from this study would, thus, be useful for healthcare service providers to improvise the intervention delivery approaches.
[article_url] => https://journals.sagepub.com/doi/full/10.1177/2150132720980629
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[publication_title] => Patients’ Perception Towards Health Education Services Received at the Enhanced Primary Healthcare Facilities: A Qualitative Exploration
[journal_title] => Journal of Primary Care & Community Health
[publisher] => Sage Publishing
[year] => December 2020
[subject] => Medical; Social Science; Humanities
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[post_date] => 2021-05-27 19:26:08
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[post_content] =>
[post_title] => Patient’s Experience in Receiving Medical Care with EnPHC
[post_excerpt] =>
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[researchers_name] => JOHARI, Mohammad Zabri
[researchers_position] => Institute for Health Behavioural Research, Ministry of Health, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/EnPHC.png
[researchers_profile] => https://www.researchgate.net/profile/Mohammad-Johari-3
[researchers_second_profile] => https://orcid.org/0000-0002-8017-622X
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[research_footprints] => patient; chronic disease; disease management; Intervention; service quality; primary health care; non-communicable disease
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/EnPHC2.png
[video] =>
[the_novelty] => This study is part of a larger process evaluation study which intended to assess and report the effectiveness of the Enhanced Primary Health Care (EnPHC) initiative implementation in selected clinics through patient’s perception and experience. There were five main themes to which the assessment paid close attention to, namely health assessment in disease progress monitoring, patient-doctor relationship and continuity of care, professionalism in service delivery, ensuring compliance in achieving health targets, and communication skills. Based on the feedback received, although the patients were unaware of the EnPHC initiative implementation, positive responses towards the new changes were gathered. Overall, the government’s attempt to transform the existing clinic health care service delivery into more structured and detailed management by emphasizing patient-centered care is perceived as a success. However, future implementations and upgrades should focus on, first, increasing the level of awareness and improving the understanding of the intervention among patients to support their experience and increase acceptance.
[the_background] => In July 2017, the Ministry of Health Malaysia proposed implementing the Enhanced Primary Health Care (EnPHC) initiative to improve primary care intervention to cope with the rise in non-communicable diseases across the nation. The main focus of the initiative is to transform the existing clinic management into a more patient-centric system. Several changes have been put in motion to achieve the transformation, including redesigning work process in the clinic, improving community intervention through community enrolment and profiling, and smoothening the referral system between clinic and hospital. However, to ensure a favorable outcome, it is important to understand how these changes have benefited the patient experience. Therefore, this study aims to assess the effectiveness of the EnPHC implementation from the patient’s perception and experience.
[the_sdg_impact] => One of the targets of the 3rd United Nations’ Sustainable Development Goal, Good health and well-being, is to provide access to good-quality healthcare services as part of the attempt to ensure healthy lives and promote well-being for all. Accordingly, governments worldwide have pledged their commitments to meet the health needs of their people and improve the nation’s primary health care service delivery. The Enhanced Primary Health Care (EnPHC) initiative is Malaysia’s attempt to fulfil its pledge in putting the health needs of its people first. The findings of this study provide valuable information on patient experience and expectations, which could be used to ensure the continuous betterment of the nation’s healthcare system.
[article_url] => https://bmcfampract.biomedcentral.com/articles/10.1186/s12875-020-01254-2
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/EnPHC-4.jpg
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[doi] => https://doi.org/10.1186/s12875-020-01254-2
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[publication_title] => Can patients make heads or tails of enhanced primary health care (EnPHC)? Experience through their own journey
[journal_title] => BMC Family Practice
[publisher] => BMC
[year] => September 2020
[subject] => Social Science; Humanities; Health Care
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[post_date] => 2021-05-27 17:26:51
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[post_content] =>
[post_title] => What Mental Distress is Experienced by Interning Doctors and How to Deal with it?
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[researchers_name] => ISMAIL, Munirah
[researchers_position] => Institute for Health Management, National Institutes of Health (NIH), Ministry of Health, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/munirah.png
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[research_footprints] => anxiety; psychological distress; medical intern; stress; COPE; healthcare professionals; mental health; health problem; medical internship; depression; cross sectional study
[graphic_abstract] =>
[video] =>
[the_novelty] => This research performed the first national-level cross-sectional study to determine the prevalence of psychological distress and its association with coping strategies among medical interns in Malaysia. The three major psychological distresses examined were stress, anxiety, and depression. Based on the data collected, the majority of interns experienced anxiety (39.9%) throughout their internship period, followed by stress (29.7%) and depression (26.2%). Noticeably, female and younger interns are highly susceptible to these conditions. Nevertheless, there has been an overall decline in anxiety and stress experiences compared to a previous study, which indicates the effectiveness of improvement strategies implemented during internship training in recent years. Moreover, most of these interns were found to have adopted healthy problem-focused coping strategies to get through the intense training process and psychological distress. As a whole, the data presented in this study would benefit healthcare institutions in incorporating the reinforcement of healthy coping strategies to ensure the effectiveness of medical internship programs.
[the_background] => The intensity in performing life-saving acts day-in and day-out is overwhelming for medical practitioners, especially the newbies and interns. Every now and then, Malaysian interns and HOs make headlines due to stress, depression, being bullied, etc. Most of the time, the mental strength of these interns are being challenged as they juggle between doing it right and adapting to the new pace and demands. Consequently, these medical interns experience psychological distress at one point or another and would need to learn to cope with it in a healthy manner. In Malaysia, most studies focused on a single psychological distress condition or based in a single center. Since there is a lack of national-level data on the prevalence of psychological distress, this study aims to collect the necessary data on this matter and examine the coping mechanisms used by the medical interns.
[the_sdg_impact] => Mental health issues have been identified as major public health problems affecting the health of the people not excluding the health professional themselves. Higher levels of psychological distress were seen among healthcare professionals where their poor mental health can compromise the quality of life and work performance and quality of care to patients. By addressing the psychological challenges faced by them and the importance of equipping the doctors, especially the young ones, with the right coping skills mechanism when dealing with stressful environments so that their mental well being is taken care of. This also contributes to the 3rd SDG - Good Health Well Being.
[article_url] => https://onlinelibrary.wiley.com/doi/full/10.1111/appy.12417
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[doi] => https://doi.org/10.1111/appy.12417
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[publication_title] => The prevalence of psychological distress and its association with coping strategies among medical interns in Malaysia: A national-level cross-sectional study
[journal_title] => Asia-pacific Psychiatry
[publisher] => Wiley Publishing
[year] => August 2020
[subject] => Social Science; Humanities
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[post_date] => 2021-05-27 17:14:57
[post_date_gmt] => 2021-05-27 09:14:57
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[post_title] => Government Doctor’s Dilemma: To Stay or To Leave?
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[researchers_name] => ABDUL RASSIP, Muhammad Nur Amir
[researchers_position] => National Institutes of Health, Ministry of Health, Malaysia
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[researchers_position_2] => Department of Community Health, Faculty of Medicine, UKM Medical Centre, Malaysia
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[original_article_reference] =>
[research_footprints] => resignation; health system; degree of freedom; human resource management; healthcare professional; statistical package for the social sciences; job satisfaction
[graphic_abstract] =>
[video] =>
[the_novelty] => The primary aim of this study is to identify the factors influencing physicians’ intention to continue serving in government hospitals instead of seeking positions in the private sector. Based on the survey conducted, job satisfaction towards governance and work processes are among the leading triggers to cause resignation. One of the effective policies established by the Ministry of Health in Malaysia is the Full Paying Patient (FPP) services which did not just improve physician retention rate, but also the quality of patient care. In a way, this initiation also reduced the government’s financial burden by allocating medical subsidies only to those who can’t afford them. The evidence gathered through this study is, therefore, capable of providing policymakers with simple guidelines in implementing appropriate and flexible strategies to retain and meet the needs of the workforce.
[the_background] => Many public sector physicians consider themselves overworked and under-compensated for all the hard work that is required from them. Thus, taking up an offer at a private hospital becomes more tempting. In fact, scholars of full government scholarships would prefer to practice under private hospitals and opt-out of the bondage due to these reasons as well as the fancy work environment. In order to keep up with the growing demands in the healthcare sector, decision-makers are required to introduce effective measures to retain their rapidly depleting workforce. Therefore, studies on physicians’ motivation to stay need to be understood and incorporated into the initiatives for a better outcome.
[the_sdg_impact] => The growing medical “brain drain” and healthcare worker shortages are concerning, especially for public sectors, rural areas, and low-income countries. Public health standards and priorities are compromised due to the migration of health professionals to urban areas, private sectors, and high-income nations. Hence, human resource management decision makers must consider the factors causing such phenomena when drafting policies. The findings of this study provide evidence-based data to guide these policymakers to improve healthcare workforce job satisfaction, wages, resources, and working conditions, ultimately increasing the retention rate in the least developed countries as intended by UNSDG 3: Good health and well-being.
[article_url] => https://www.alliedacademies.org/articles/physicians-intention-to-leave-from-malaysia-government-hospitals-with-existing-retention-strategy-13327.html
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[doi] => https://doi.org/10.35841/public-health-policy.4.3.30-37
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[publication_title] => Physicians intention to leave from Malaysia government hospitals with existing retention strategy.
[journal_title] => Journal of Public Health Policy and Planning
[publisher] => Allied Academies
[year] => July 2020
[subject] => Social Science; Humanities
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[post_date] => 2021-05-27 17:02:33
[post_date_gmt] => 2021-05-27 09:02:33
[post_content] =>
[post_title] => How do Malaysian Patients Benefit from the Cluster Hospital Initiative?
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[researchers_name] => NG, Rui Jie
[researchers_position] => Institute for Health Management, National Institutes of Health, Malaysia
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[researchers_name_2] => KHAIRUL ANUAR, Ili Liyana
[researchers_position_2] => Centre for Organisational Excellence Development, Institute for Health Management, Ministry of Health, Malaysia
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[original_article_reference] =>
[research_footprints] => healthcare system; patient satisfaction; systematic review; service delivery; integrated care; thematic analysis; healthcare service; universal health coverage; patient-centred care
[graphic_abstract] =>
[video] =>
[the_novelty] => Based on the experience of Malaysian patients, this study highlights patient benefits from hospitals merging in the Cluster Hospital Initiative (CHI). The key benefits recognized are the changes in healthcare service, time spent on healthcare-related activities, and financial cost. After conducting interviews with Malaysian patients in these merged hospitals, researchers found that patients were satisfied with the increased availability of specialists and improved quality of care. Patients also complimented the shorter waiting time for medical procedures and consultation as well as reduced traveling time to the hospitals. Moreover, patients are pleased with the lower healthcare cost and higher financial savings as a result of this initiative. Nevertheless, this study can further expand by researching other features of this initiative, such as the healthcare personnel’s experience and assessing its efficiency.
[the_background] => Cluster Hospital Initiative (CHI), different from the conventional hospital mergers, focuses on integrating resources from a network of hospitals in the same region through a well-coordinated merger. Such practice has been widely adopted in many countries, more commonly in private healthcare systems. Malaysia only implemented the concept in 2010, inspired by evidence from other studies. Previous studies mainly focused on its impact on hospital efficiency, price and cost changes, clinical outcomes, and quality of care. However, this is one of the first studies to focus on the patients’ and caregivers’ experience after the establishment of CHI. This study intended to determine the patients’ and caregivers’ experience in the healthcare services of the CHI locations. This was done by conducting an in-depth interview with the patients and caregivers in these hospitals. This study could help create a comprehensive hospital merging system that allows all Malaysians access to quality hospital care.
[the_sdg_impact] => In an effort to support the Good Health and Well-being goal under the global Sustainable Development Goals, the Ministry of Health Malaysia aims to provide a more streamlined and cohesive healthcare delivery by utilising all facilities and shared resources. The merging of hospital services is a change in the existing way of healthcare being delivered to the people of Malaysia, therefore their acceptance and experience may provide useful insights to how the initiative can be improved for its longevity. With that in mind, this research looks into public acceptance and experience following the implementation of CHI. Ultimately, the findings could provide insights for policymakers to further strengthen the initiative towards its sustainability.
[article_url] => http://www.pertanika.upm.edu.my/pjssh/browse/regular-issue?article=JSSH-6368-2020
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[doi] => https://doi.org/10.47836/pjssh.28.4.09
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[publication_title] => Exploring Patients’ Experience on Hospital Merger: Have they benefited from Cluster Hospital Initiative in Malaysia?
[journal_title] => Pertanika Journal of Social Science and Humanities
[publisher] => UPM Press
[year] => December 2020
[subject] => Social Science; Humanities
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[post_date] => 2021-05-27 15:33:51
[post_date_gmt] => 2021-05-27 07:33:51
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[post_title] => Mathematical Model to Forecast COVID-19 Transmission Amidst Movement Control Order
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[researchers_name] => GILL, Balvinder Singh
[researchers_position] => Institute of Medical Research, National Institutes of Health, Malaysia
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[researchers_profile] => https://www.researchgate.net/profile/Balvinder-Gill
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[researchers_name_2] => LABADIN, Jane
[researchers_position_2] => Department of Computational Science and Mathematics, University Malaysia Sarawak, Malaysia
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[research_footprints] => susceptible; movement control order; reproduction number; public health; middle east respiratory syndrome; isolation; exposed; severe acute respiratory syndrome; protective equipment; movement; movement control; non-pharmaceutical interventions; mathematical modelling; novel coronavirus; infectious; novel pathogen; epidemic control; crisis preparedness and response centre; COVID-19
[graphic_abstract] =>
[video] =>
[the_novelty] => This study estimated the COVID-19 transmission dynamics and provided forecasts of case trends by extending the previously developed SEIR mathematical model to include traced, exposed, infected, isolated, and quarantined components to develop a robust forecasting model, the study took into consideration parameters such as the proportion of close contacts traced per day, transmissibility, and probability of a susceptible person becoming infected. The findings of this study showed a reduction of peak active cases by 99.1% and average contact per case following the implementation of movement control order (MCO). Therefore, it is proven that the institution of effective control measures did contribute to lowering the spread of the virus. Overall, the results emphasize how crucial it is for the public to comply with the control measures. Policymakers and health authorities can use these findings as evidence to guide the timely institution of control measures in breaking the COVID-19 chain of transmission.
[the_background] => Little introduction is required to emphasize the devasting impacts of the COVID-19 pandemic. Despite intensive public health efforts in screening and imposing social-distancing and citywide lockdowns, the chain of transmission seems unbreakable, judging by the rise of global cases and deaths. Several studies have explored various mathematical models to understand the transmission dynamics and forecast the progress of the pandemic. The outcome of which has proven that efficient human-to-human transmission exists. However, there is a lack of evidence on the effect of movement control measures, isolation, and quarantine efforts on the transmission dynamics of COVID-19. Therefore, this study aims to develop a robust mathematical model forecasting COVID-19 transmission by considering the control measures implemented in the country.
[the_sdg_impact] => As of 1st August 2021, more than 140 million people have been infected by the COVID-19 virus, with almost 3.2 million lives lost. There are devasting reports of second-waves and third-waves affecting countries globally resulting in dire consequences in terms of health effects and deaths which are more severe than the previous waves. Although vaccination is being administered, strict control measures are still required to ensure the transmission is kept under control. The findings of this study are proof of the effectiveness of strict movement control orders in controlling the spreading of the virus in hopes of ending this pandemic (SDG 3: Good health and well-being).
[article_url] => https://www.mdpi.com/1660-4601/17/15/5509
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/COVID-19-2.jpg
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[doi] => https://doi.org/10.3390/ijerph17155509
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[publication_title] => Modelling the Effectiveness of Epidemic Control Measures in Preventing the Transmission of COVID-19 in Malaysia
[journal_title] => International Journal of Environmental Research and Public Health
[publisher] => MDPI
[year] => July 2020
[subject] => Medical; Covid-19; Biomedical Epidemiology
)
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[post_date] => 2021-05-27 15:02:55
[post_date_gmt] => 2021-05-27 07:02:55
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[post_title] => Genetic Profiling of the Malaysian Indian Community
[post_excerpt] =>
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[researchers_name] => AHMAD FAUZI, Nurul Aain
[researchers_position] => Immunogenetic Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/community2.png
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[researchers_name_2] => TOO, Chun Lai
[researchers_position_2] => Immunogenetic Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Malaysia
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[original_article_reference] =>
[research_footprints] => polymerase chain reaction; applied biosystems; indian diaspora; Haplotypes; allele frequency; medical research; alleles
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/210628_Phylogenetic-Tree-Pic_Final-Version.png
[video] =>
[the_novelty] => This study reports the genetics information for the third largest ethnicity in Malaysia, the Southeast Asia Indian community. The genetic information for five different genes (i.e., HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1) were identified in 271 healthy Indian controls sourced from the multicentred Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) case-control study. In this report, a set of specific number coding represented the most common identified alleles for each studied gene, for example, HLA-A*24:02, HLA-B*51:01, HLA-C*06:02, HLA-DRB1*07:01, and HLA-DQB1*06:01. A significant deviation from the Hardy-Weinberg Equilibrium Proportion for HLA-A, HLA-C, and HLA-DRB1 was observed, and a combination of five common signals for each gene was reported. The generated genetic data is useful for scientists working to understand the role of genes in health and disease(s).
Hardy-Weinberg Equilibrium: a theorem used to state that allele and genotype frequencies in a population will remain constant from generation to generation in the absence of other evolutionary influences
[the_background] => Indians make up the third-largest ethnicity in Malaysia, with origins mainly from the southern part of India. Comprehensive genetic profiling of Malaysian Indians establishes a novel reference to appreciate the genetic makeup and changes that occur over time and are considered especially interesting in diasporic origins. This is because such data highlights the influence of geographical settings in the gene flow hypothesis. In addition, identification of genes commonly associated with specific genetic disorders or disease resistance across or within specific ethnicities adds to the global/general understanding of genetic influence in both health and disease, with consequences on disease prevention and treatment. Therefore, this report aims to provide genetic information of the Malaysian Indian community by using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods.
[the_sdg_impact] => The HLA genes are the most diverse in the human genome. The continuous study of the field has led to critical clinical applications and significant scientific impacts, including breakthroughs in understanding rheumatoid arthritis (RA), drug hypersensitivity, organ donor-recipient matching, and population genetics. Acknowledging the importance of HLA-genes in both health and disease, the authors have reported and established the common HLA-genes among 271 healthy Indians in Malaysia as a novel and additional reference in the Allele Frequencies Network Database (AFND). (SDG 3: Good health and well-being).
[article_url] => https://www.sciencedirect.com/science/article/abs/pii/S0198885920302202
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/genes-2.jpg
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[doi] => https://doi.org/10.1016/j.humimm.2020.04.004
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[publication_title] => HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 271 Southeast Asia Indians from Peninsular Malaysia
[journal_title] => Human Immunology
[publisher] => Elsevier
[year] => June 2020
[subject] => Medical; Immunogenetic; Immunology
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[post_date] => 2021-05-27 14:36:00
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[post_title] => Investigation of Mutation Contributing to Insecticide Resistance in Backcrossed Wolbachia Mosquitoes
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[researchers_name] => HARSHMAN, Nancy Endersby
[researchers_position] => School of BioSciences, University of Melbourne, Australia
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[researchers_name_2] => AHMAD, Noor Afizah
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[research_footprints] => Hardy–Weinberg equilibrium; pyrethroid resistance; sodium channel; odds ratios; genotype frequency; genetic background; single nucleotide polymorphism; aedes albopictus; anopheles gambiae; insecticide; aedes aegypti
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Poster-Wolba-New2-scaled.jpg
[video] =>
[the_novelty] => This study identified the mutation that contributes to insecticide resistance in 2 different dengue vector mosquitoes, Aedes species. The study aimed at replicating the mutations responsible for the resistance found in wild type (from the field) in the laboratory reared Wolbachia mosquitoes through backcrossing. A cross-breed generation of mosquitoes was created by mating the mosquitoes from the field and the Wolbachia bacteria infected female colony from the laboratory and the mutations causing insecticide resistance was investigated across all species. The outcome of the research highlighted the resistance genotype and phenotype persisted in backcrossed populations in comparison with wild mosquitoes. The first mutation (F1534L) in Malaysia was also identified in one of the wild species, Ae. Albopictus which is an indication of increasing resistance towards the pesticide control methods being largely employed to contain the dengue situation in the country. The outcome of this study, thus, demonstrates that resistance mutations provide a survival advantage to Wolbachia Ae. aegypti mosquitoes, which must be maintained in laboratory lines by regular backcrossing, eventually help the sustainability of the Wolbachia mosquitoes in the field.
[the_background] => In Malaysia, an alternative method of dengue reduction is employed which comprises releases of Ae. aegypti mosquitoes infected with a bacterium, Wolbachia, found naturally in other insects. Wolbachia turns the mosquitoes into incompetent vectors so they do not transmit the disease. Regular backcrossing between laboratory grown Wolbachia mosquitoes and field mosquitoes preserve the pesticide resistance characteristics which provides a survival advantage to Wolbachia mosquitoes. However, Wolbachia mosquitoes are reared in the laboratory before release and must be able to survive in the field where they will encounter insecticides. Therefore, our study demonstrates benefits of crossing laboratory mosquitoes to those from the field over generations, so that the mosquito lines acquire field resistance characteristics, specifically in terms of mutations in the sodium channel gene.
[the_sdg_impact] => According to the statistics from the Ministry of Health, a total of 130 101 dengue cases and 182 deaths were reported in 2019. What’s more troubling is the percentage of increase of the cases and death rate compared to 2018, recording a 61.4% and 23.8% increase respectively. WHO estimates 390 million dengue virus infections annually with 70% occurrence in Asia and the staggering figures demonstrates the significance of efficient control methods to contain the situation. Two major setbacks of the existing dengue control method using chemicals are the potential toxicity to the environment and emergence of resistance to the pesticide treatment. In accordance with that, intervention using Wolbachia mosquitoes as an alternative will support two crucial goals of sustainable development by the United Nations, UNSGD 3, to promote good health and wellbeing and UNSDG 15, to protect the environment. Inevitably, this study paves way for the country and hopefully to the Asian region that is mainly affected by dengue to optimise this substitute biological method to prevent dengue infection.
[article_url] => https://www.mdpi.com/2075-4450/11/8/529
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Wolbachia-3.jpg
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[doi] => https://doi.org/10.3390/insects11080529
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[publication_title] => Characterization of Sodium Channel Mutations in the Dengue Vector Mosquitoes Aedes aegypti and Aedes albopictus within the Context of Ongoing Wolbachia Releases in Kuala Lumpur, Malaysia
[journal_title] => Insects
[publisher] => MDPI
[year] => August 2020
[subject] => Medical; Entomology; Dengue
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[post_date] => 2021-05-27 14:12:42
[post_date_gmt] => 2021-05-27 06:12:42
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[post_title] => Potential Remedy to Manage Obesity through the Consumption of Red Edible Seaweed Supplement
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[researchers_name] => BALASUBRAMANIAM, Vimala
[researchers_position] => Nutrition Metabolic & Cardiovascular Research Centre, Institute for Medical Research, Malaysia
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[research_footprints] => edible seaweed; low-density lipoprotein anti-obesity; histopathology weight loss; high-density lipoprotein; insulin resistance; alkaline phosphatase; analysis of variance; ;weight gain; Rhodophyta; hematoxylin and eosin; eucheuma denticulatum; food intake; standard deviations; fat mass; in vivo; acute oral toxicity; chronic disease
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/graphical-abstract-Dr.-Vimala-1_001.png
[video] =>
[the_novelty] => This study provided evidence on the anti-obesity properties of Eucheuma denticulatum, a red edible seaweed, in animal models. When fed with a high-fat diet and supplemented with E. denticulatum freeze-dried powder, rats showed an increased protective effect against visceral fat gain and lowered BMI and Lee index figures. Findings also showed improvement in insulin sensitivity and liver function and reduced dietary fat uptake when the metabolic biomarkers such as HOMA-IR, TG, glucose, leptin, ghrelin, and insulin were screened. In addition, a preliminary observation on acute toxicity as a result of this seaweed supplement suggests a maximum of 2000 mg kg-1 is safe to be consumed by the rats in a single oral administration. Based on the evidence shared, future research could explore options of including this species of red edible seaweed as a complementary treatment to manage obesity. However, further clinical research and evidence are required before such administration.
[the_background] => The major strategy for prevention and treatment of obesity is lifestyle modification, including diet control and physical exercise. Diet programs may produce weight loss over the short term, but maintaining weight loss frequently is difficult. There are several anti-obesity drugs commercially available including orlistat, rimonabant and sibutramine. However, the potential toxicity may limit their usage. Thus, continuous search for remedies with minimum side effects is paramount. E. denticulatum has shown to have health benefit properties such as anti-diabetic, anti-obesity, and antiinflammatory activities using in vitro models. At present, the overall effect on in vivo models and metabolic responses is relatively unknown. Thus, this study will further enhance scientific evidence and strengthen the claims of seaweed as a nutritious food.
[the_sdg_impact] => According to the statistics presented by World Health Organization (WHO), 1.9 billion adults worldwide were reportedly overweight in 2016, with 650 million were recognized as obese. The health consequences of being overweight and obese are dire as to increased risk for the development of cardiovascular diseases, diabetes, musculoskeletal disorders, and even some cancers. Therefore, to reduce the risk of premature deaths and disabilities caused by these non-communicable diseases resulting from obesity, this study presents E. denticulatum as a potential natural supplement to manage excessive diet-induced weight gain (SDG 3: Good health and well-being).
[article_url] => https://link.springer.com/article/10.1007/s10811-020-02061-z
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/seaweed.jpg
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[publication_title] => Effect of red edible seaweed Eucheuma denticulatum on diet-induced obesity in vivo
[journal_title] => Journal of Applied Phycology
[publisher] => Springer Nature
[year] => February 2020
[subject] => Medical; Nutrition Metabolic; Cardiovascular
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[post_date] => 2021-05-26 21:44:56
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[post_title] => Estimating Hepatitis Infection Prevalence in Middle-income Country
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[researchers_name] => MUHAMAD, Nor Asiah
[researchers_position] => Sector Evidence Based in Healthcare, National Institute of Health, Malaysia
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[research_footprints] => hepatitis B virus; hepatitis C virus; confidence interval; hepatitis B; missing at random; odds ratios
[graphic_abstract] =>
[video] =>
[the_novelty] => This study recognizes the importance of understanding the transmission patterns of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in the community. In 2016, The Malaysian Cohort (TMC) project was initiated to estimate the prevalence rate of HBV and HCV infection among the Malaysian adult population. Primarily, the study analyzed the presence of hepatitis B surface antigen (HBsAg), antibody to hepatitis B core antigen (anti-HBc), and antibody to hepatitis C virus (anti-HCV) in the blood sample to determine the seroprevalence of the infections. As a result, the prevalence of HBsAg, anti-HBc, and anti-HCV positivity among Malaysian adult population were 4%, 20%, and 0.3%, respectively. Thus, it was concluded that the seroprevalence of HBV infection in Malaysia is low and intermediate for HCV infection. With that said, male and rural residents were found to be at higher risk than the others. The study also elaborated the impact of geographical positioning of the community, lifestyle, cultural activity, and marital status as possible causes of the transmission. Ultimately, the data produced and factors identified concerning HBV and HCV infection transmission in Malaysia could be beneficial for policymakers to strategize the national immunization program and eradicate the diseases.
[the_background] => Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections largely contribute to the rise of liver-related illnesses. Although the infections are preventable and treatable if diagnosed at an early stage, many are unaware that they are carriers of the viruses due to the asymptomatic nature of the infections. In Malaysia, the Ministry of Health (MoH) foresee a spike in the infection rates for HBV and HCV in the next 2 decades. In order to control this endemic threat, it is crucial for healthcare service providers and policymakers to understand the prevalence of HBV and HCV infections in the Malaysian community. However, there are no population-based studies conducted to date which could provide such data. Therefore, this study conducted a population-based study on HBV and HCV infection prevalence among the Malaysian adult population to improve disease control and early screening strategies.
[the_sdg_impact] => According to the World Health Organization (WHO), approximately 325 million people live with a viral hepatitis infection globally. It projects that an estimated 4.5 million premature deaths could be prevented in low- and middle-income countries by 2030 through structured immunization programs, early screening, and awareness campaigns. With Malaysia having an unclear estimation of the infected population, any hepatitis vaccination programs initiated may not provide the best outcome. Therefore, the data provided by this study would bring the Malaysian healthcare policymakers a step closer to understanding the prevalence of hepatitis infections in the community. With that, comprehensive policies and interventions can be drawn to improve the national vaccination program and significantly reduce the new hepatitis infections as aimed by WHO and UN SDG 3: Good health and well-being.
[article_url] => https://www.nature.com/articles/s41598-020-77813-5
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/hepatitis-2.jpg
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[publication_title] => Seroprevalence of hepatitis B virus and hepatitis C virus infection among Malaysian population
[journal_title] => scientific reports
[publisher] => Nature Portfolio
[year] => December 2020
[subject] => Medical
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[post_date] => 2021-05-26 17:42:59
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[post_title] => Factors Influencing Primary Healthcare Providers’ Perception towards Implementation of New Intervention
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[researchers_name] => LOW, Lee Lan
[researchers_position] => Institute For Health Systems Research, Ministry of Health Malaysia, Malaysia
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[researchers_name_2] => ABDULLAH, Zalilah
[researchers_position_2] => Centre for Health Policy Research Institute for Health Systems Research, Malaysia
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[research_footprints] => Non-communicable diseases; healthcare clinic; nongovernmental organisations; service delivery; implementation research; primary healthcare; healthcare provider; qualitative
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/91F4DAAD34AB427089CF5115D9534D4B990.png
[video] =>
[the_novelty] => The primary aim of this study is to examine the readiness of public primary healthcare providers in accepting changes in non-communicable disease (NCD) patient management intervention to be proposed by the Enhanced Primary Healthcare (EnPHC) initiative. By using the Consolidated Framework of Implementation Research (CFIR), the findings suggested that, at large, the healthcare providers are open and receptive towards changes. However, several concerns need to be addressed before implementing the initiative, namely shortage of staffing, high patient load, and existing clinic facilities. Furthermore, the varying cultural and local adaptations of the implementation and its management may also influence the healthcare providers’ perception of the changes. With this information, policymakers and clinic managers would be able to mold the intervention accordingly and allocate the resources efficiently to produce favorable outcomes of the EnPHC initiative; thus, improving the primary healthcare setting and NCD management.
[the_background] => Concerned by the rise of the non-communicable disease (NCD) burden in Malaysia, the Ministry of Health (MoH) proposed the Enhanced Primary Healthcare (EnPHC) initiative in selected public primary healthcare clinics. To design a feasible intervention model, baseline information on the perception of healthcare providers towards change is necessary, so is the understanding of the existing barriers in terms of human resources and infrastructure. Therefore, this study aimed to understand the current conditions of the local clinics and the challenges concerning the healthcare providers when it comes to accepting change, especially in NCD patient management.
[the_sdg_impact] => Apart from intending to reduce NCD-led premature mortality rate, UN SGD 3: good health and well-being, also emphasizes on improving the quality of essential healthcare system and services. To do so, it is crucial for policymakers to introduce supporting intervention strategies and initiatives, particularly to ensure NCD patients’ needs are met and well managed. Therefore, the findings of this study highlight the need to engage with healthcare service providers and recipients prior to the proposal of any intervention. By assessing the expectations, acceptance, and concerns of relevant parties, policymakers would be able to draft and implement a better and more practical national-level intervention, especially for healthcare services.
[article_url] => https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-019-4312-x
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[publication_title] => Assessing receptiveness to change among primary healthcare providers by adopting the consolidated framework for implementation research (CFIR)
[journal_title] => BMC Health Services Research
[publisher] => BMC
[year] => July 2019
[subject] => Medical; Non Communicable Diseases
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[post_date] => 2021-05-26 16:55:47
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[post_title] => Protocol to Tailor the Person-centred Practice Framework to Fit Local Context
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[researchers_name] => BALQIS-ALI, Nur Zahirah
[researchers_position] => Centre for Health Outcomes Research, Institute for Health Systems Research, Malaysia
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[research_footprints] => average variance extracted; primary care clinic; exploratory factor analysis; structural equation modeling; composite reliability; healthcare provider; confirmatory factor analysis; factor analysis; ethics committee
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Flow-Chart-figure.png
[video] =>
[the_novelty] => This study designed a protocol to adapt and validate the Person-Centred Practice Inventory-Staff (PCPI-S) questionnaire to measure person-centredness among the primary healthcare providers in Malaysia. The adaptation and validation process are suggested to be conducted in 4 stages: tool review, translation, pre-testing and cognitive interviewing, and psychometric evaluation, in the given order. By developing such a protocol, this study aims to translate the person-centred framework into practice through provision of a guide for learning and development in supporting person-centred care (PCC) for anyone who would like to implement the same practice in their local environment.
[the_background] => The person-centred practice framework by McCormack and McCance focused on the therapeutic relationship between healthcare providers and service users. Among the domains emphasized in the theoretical framework are the healthcare provider’s attributes, the care environment and processes, and person-centred practices and outcomes. Factors such as local culture and norms are essential for the effective delivery of PCC and evaluation tool designing. This study focuses on designing a comprehensive protocol to measure person-centredness among healthcare providers which is adapted and validated to fit the Malaysian primary healthcare context.
[the_sdg_impact] => Person-centred care has been acknowledged as a practice to replace the conventional medical and disease centered practice. The ultimate objective of the United Nations (UN) and World Health Organization (WHO) is to improve health outcomes by reducing mortality, ending epidemics, preventing and treating diseases, and refining care management quality (SDG 3: Good health and well-being). This study particularly focuses on catering the person-centred practice framework to fit into a developing country context in terms of culture, language, and norm to reflect on the practices of healthcare providers.
[article_url] => https://bmjopen.bmj.com/content/10/3/e034128.info
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[publisher] => BMJ
[year] => March 2020
[subject] => Medical
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[post_title] => Effective Recruitment Strategies for Surveys Related to Primary Care
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[the_novelty] => How responsive are the doctors in Malaysia towards an international survey? This study showed that by adapting several strategies, favourable response rates could be obtained for surveys which require participation of doctors from public and private primary care settings in Malaysia. These strategies included having a national coordinator, sending out personalised invitations for recruitment, conducting face-to-face interview, rewarding non-monetary incentives and, last but not least, obtaining endorsement from professional associations, state health departments as well as private clinic managers. The details and reasons of non-responders were also recorded via a set of non-response questionnaires. In future studies, the non-respondents obtained are recommended to be used for making valid inferences about the target population.
[the_background] => The international QUALICOPC (Quality and Cost of Primary Care) study was conducted in various countries to evaluate the performance of primary care in the respective countries. In order to achieve their goals, data was collected from primary care doctors and patients via surveys. However, while attempting to engage the doctors, there are bound to be hurdles such as time constraint, confidentiality, lack of interest, and barriers set by ‘gatekeepers’. Thus, this study was carried out to describe the effective recruitment strategies, the response rates and the reasons for non-response of QUALICOPC study in Malaysia. The output of this research could facilitate future surveys involving primary care doctors.
[the_sdg_impact] => To improve the quality of health services rendered, research on primary care is necessary for the purpose of benchmarking. The research often requires data collection from both doctors and patients. This study has shared and discussed the effectiveness of several strategies which could increase the response rate in collecting the relevant data. Hence, its objective is well-aligned with UNSDG 9: Industry, Innovation & Infrastructure by helping to enhance scientific research.
[article_url] => https://www.cambridge.org/core/journals/primary-health-care-research-and-development/article/recruitment-and-participation-of-a-survey-in-a-publicprivate-primary-care-setting-experience-from-the-qualicopc-malaysia/D46D4E6091FA869F5FD459DDFB77F05A
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Recruitment-3.jpg
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[doi] => https://doi.org/10.1017/S1463423620000511
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[publication_title] => Recruitment and participation of a survey in a public–private primary care setting: experience from the QUALICOPC Malaysia
[journal_title] => Primary Health Care Research & Development
[publisher] => Cambridge University Press
[year] => November 2020
[subject] => Medical; Primary Health Care
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[post_date] => 2021-05-26 15:24:17
[post_date_gmt] => 2021-05-26 07:24:17
[post_content] =>
[post_title] => Suboptimal BP Control and Hypertension Care by Malaysia’s Public Primary Care Clinics
[post_excerpt] =>
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[researchers_name] => LIM, Ming Tsuey
[researchers_position] => Healthcare Statistics Unit, Clinical Research Malaysia, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/testing2.png
[researchers_profile] => https://www.researchgate.net/profile/Ming-Lim-8
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[research_footprints] => primary care clinic; calcium channel blockers; blood pressure; risk factor; clinical practice; chronic kidney disease
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/IMG_3192-scaled.jpg
[video] =>
[the_novelty] => Is the current management of hypertensive patients feasible and effective enough? By examining patients’ medical records between 1st November 2016 and 30th June 2019, this study showed that there was hardly any improvement in the hypertensive care in Malaysia’s public primary care clinics compared to how it was in the previous decade. The blood pressure (BP) control was found to be suboptimal in those clinics. There were gaps between guidelines and actual clinical practice in the process of care for hypertension management which has a huge room for improvement. The authors suggested examining the optimal coordination, consultation, counseling and good communication skills for implementing effective management in future studies.
[the_background] => The last known evaluation for the process of care for hypertension in Malaysia was conducted about a decade ago. Meanwhile, most of the evaluations focussed on the burden of hypertension in the Malaysian population. That being said, there is a very limited number of reported evaluations on process of care and BP control. Hence, this study was conducted to investigate the latest process of care for hypertension management and to examine the association between the process and BP control among hypertensive patients in Malaysia’s public primary care clinics. The outcome serves as a good reference in overcoming the current suboptimal management of hypertensive patients.
[the_sdg_impact] => In 2015, 1.13 billion people worldwide suffered from hypertension and two-thirds of them were living in low- and middle-income countries. Less than 1 out of 5 people with hypertension have the problem under control (source: WHO). The findings of this study would be beneficial to create and increase hypertension awareness and improve its management of hypertension among the patients in public clinics as hypertension was largely managed in this healthcare setting. In return, it contributes to risk reduction and better management of national health which is part of the targets of UNSDG 3: Good Health & Well-Being.
[article_url] => https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237083
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/hypertension-2.jpg
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[publication_title] => Quality of hypertension management in public primary care clinics in Malaysia: An update
[journal_title] => PLOS One
[publisher] => PLOS
[year] => August 2020
[subject] => Medical; Hypertension
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[post_date] => 2021-05-26 12:47:31
[post_date_gmt] => 2021-05-26 04:47:31
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[post_title] => Rising Burden of Dementia Exerts Heavy Toll on Caregivers
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[researchers_name] => Shubash Shander Ganapathy
[researchers_position] => Survey Research Centre, Institute for Public Health, National Institutes of Health, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/shubash.png
[researchers_profile] => https://www.researchgate.net/profile/Shubash-Ganapathy
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[research_footprints] => social support; quality of life; affirmative action; dementia; public health; caregivers; longitudinal study; systematic review; activities of daily living
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Graphical-Abstract-Prevalence-of-dementia-and-quality-of-life-of-caregivers-of-people-living-with-dementia-in-Malaysia.png
[video] =>
[the_novelty] => What is the prevalence of dementia in Malaysia and how does it affect the life of caregivers involved? This study reported that the prevalence of dementia in Malaysia was 8.5 % among people of age 60 years and above, with the majority of them being women. A larger portion of dementia patients are also found to have no formal education and living in rural areas. As a whole, the prevalence rate is considered high since it exceeded the global dementia prevalence of 5 to 8 % as estimated by WHO. The findings suggested that the quality of life (QoL) of caregivers of people living with dementia (PLwD) depends mainly on the functional capacity of the PLwD and the availability of social support. Since these caregivers do not socialize much, physicians attending to the PLwD are encouraged to inform and educate the caregivers as part of establishing a solid support system.
[the_background] => Malaysia is set to become an aging society by 2030 when 15 % of its population will be 60 years old and above (Source: Department of Statistics). Such a trend implies that the number of dementia cases will increase accordingly. In order to be well-prepared to address this, it is necessary to understand the needs and support needed to be given to the caregivers of PLwD, as the QoL of the caregivers will in turn affect the well-being of PLwD. Other than determining the prevalence of dementia, this study aimed to understand which factors have the most influence on caregivers’ QoL and discusses ways to improve the QoL of caregivers of PLwD.
[the_sdg_impact] => Dementia is one of the major causes of disability and dependency among older people worldwide. Its impact is often overwhelming for both PLwD and their families as well as caregivers. The outcome of this research proved that an urgency is needed in attending to the burden of care associated with the increasing prevalence of dementia and improving the QoL of caregivers of PLwD. Hence, this research is well-aligned with UNSDG 3: Good Health & Well-being in ensuring healthy lives and promoting well-being.
[article_url] => https://onlinelibrary.wiley.com/doi/10.1111/ggi.14031
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/dementia-3.jpg
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[doi] => https://doi.org/10.1111/ggi.14031
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[publication_title] => Prevalence of dementia and quality of life of caregivers of people living with dementia in Malaysia
[journal_title] => Geriatrics & Gerontology International
[publisher] => Wiley Publishing
[year] => December 2020
[subject] => Medical; Non Communicable Diseases
)
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[post_date] => 2021-05-26 11:26:35
[post_date_gmt] => 2021-05-26 03:26:35
[post_content] =>
[post_title] => Latest Prevalence & Risk Factors of Chronic Kidney Disease in Malaysia
[post_excerpt] =>
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[post_name] => latest-prevalence-risk-factors-of-chronic-kidney-disease-in-malaysia
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[researchers_name] => SAMINATHAN, Thamil Arasu
[researchers_position] => Centre for Non Communicable Diseases Research (CNCDR), Institute of Public Health, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Kidney-.png
[researchers_profile] => https://www.researchgate.net/profile/Thamil-Saminathan
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[research_footprints] => living quarters; risk factor; estimated glomerular filtration rate; body mass index; clinical practice guidelines; blood pressure; public health; diabetes mellitus; glomerular filtration rate; confidence intervals; prevalence; kidney disease; chronic kidney disease
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/CKD-Graphical-Abstract-IES-1.png
[video] =>
[the_novelty] => What is the latest prevalence of chronic kidney disease (CKD) in Malaysia? This study reported that the CKD prevalence in Malaysia increased from 9.07% (2011) to 15.48% (2018). The factors associated with CKD were hypertension, diabetes mellitus, increasing body mass index (BMI), and increasing age. The results were derived from several significant metrics including estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (uACR) of a total 1,047 adults throughout Malaysia. Studies to re-assess the trends in CKD prevalence should be carried out regularly in the future in order to evaluate the effectiveness of effort taken to prevent and treat CKD.
[the_background] => In Malaysia, 37,781 patients were on renal replacement therapy by the end of 2016. Such a phenomenon posed a significant burden to the national healthcare budget. Meanwhile, there was no regular update on the prevalence of CKD in Malaysia. Hence, it is necessary to have that information so as to prevent, treat and improve the healthcare of CKD patients. This study was carried out to investigate the current prevalence of CKD among adults in Malaysia and its associated risk factors. The outcome could guide the Ministry of Health to strategise feasible plans and budgets to address CKD.
[the_sdg_impact] => 10% of the population worldwide is affected by CKD which is a global health crisis (source: WHO). Nonetheless, with early diagnosis and treatment, it's possible to delay or stop the progression of kidney disease. By reporting the increasing trend of CKD prevalence and the potential associated risk factors, this study showed the policymakers the urgency to deal with the current state of CKD in Malaysia. In other words, it strengthens the capacity of Malaysia for early warning, risk reduction and management of CKD. Thus, this study helps to realize UNSDG 3: Good Health & Well-being.
[article_url] => https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-020-01966-8
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Kidney-3.jpg
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[publication_title] => Prevalence of chronic kidney disease and its associated factors in Malaysia; findings from a nationwide population-based cross-sectional study
[journal_title] => BMC Nephrology
[publisher] => BMC
[year] => August 2020
[subject] => Medical; Non Communicable Diseases
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[post_date] => 2021-05-26 10:45:17
[post_date_gmt] => 2021-05-26 02:45:17
[post_content] =>
[post_title] => Identifying the Impact of Kiddie Cigarette Packs on Smoking
[post_excerpt] =>
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[post_name] => identifying-the-impact-of-kiddie-cigarette-packs-on-smoking
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[researchers_name] => HALIZAH MAT, Riffin
[researchers_position] => Institute for Public Health, National Insitutes of Health, Malaysia
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Cigarette.png
[researchers_profile] => https://www.researchgate.net/profile/Halizah-Mat-Rifin
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[research_footprints] => Cigarette; cigarette stick; confidence interval; ;tobacco control; packaging; smoking prevalence; illicit cigarette; randomised controlled trials; systematic review; tobacco industry; cigarette pack; tobacco use; chronic disease
[graphic_abstract] => https://iesresearch.solutions/wp-content/uploads/2021/05/Graphical-abstract-Kiddie-packs.jpg
[video] =>
[the_novelty] => Does the packaging size of cigarettes help in reducing cigarette consumption? This protocol article has proposed a comprehensive method to conduct a systematic review focussing on the potential impact of kiddie-size cigarette packaging on smoking habits and patterns. The method involves reviewing original articles discussing the impact of kiddie packs on smoking sourced from a range of databases with no restrictions on the publication date, language, and study designs. The findings include the initiation of smoking and urge to buy cigarettes in the general population, and the attempt to reduce cigarette consumption among current smokers.
[the_background] => Small/kiddie cigarette packs are two-edge swords whereby they might help heavy smokers to quit smoking but, on the other hand, encourage minor and lower-income consumers to smoke due to their lower prices. After kiddie packs were banned in several countries, the tobacco industry has been trying to reintroduce kiddie packs by claiming that doing this can be a solution for the surge of contraband cigarettes. To resolve the contradicting intentions, an evidence-based conclusion is needed for the actual impact of kiddie-size cigarette packaging. Hence, this protocol article proposes the first-ever systematic review to be conducted to identify the impact of kiddie packs on patterns of tobacco consumption. With the proven impact, the review serves as a solid reference for governments to control the distribution of kiddie packs according to the effort in lowering the consumption of tobacco.
[the_sdg_impact] => WHO states that tobacco kills up to half of its users, which is more than 8 million people each year. Therefore, tobacco is undeniably one of the biggest public health threats which needs to be addressed. However, the actual impact of kiddie cigarette packs on tobacco consumption has yet to be concluded. This article proposes a practical protocol to identify the impact of kiddie packs on smoking. As one of SDG 3 aims is to reduce premature mortality on NCDs, the evidence-based study on the kiddie packs is necessary to help the policymakers in regulating kiddie packs to control tobacco consumption.
[article_url] => https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-019-1263-6
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Cigarette-2.jpg
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[doi] => https://doi.org/10.1186/s13643-019-1263-6
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[publication_title] => A systematic review protocol on small/kiddie cigarette packaging size and its impact on smoking
[journal_title] => Systematic Reviews
[publisher] => BMC
[year] => January 2020
[subject] => Medical; Non Communicable Diseases
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[post_date] => 2021-05-17 11:08:50
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[post_title] => Gene Regulatory Network as a Tool to Understand Vertebrate Head Evolution
[post_excerpt] =>
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[post_name] => gene-regulatory-network-as-a-tool-to-understand-vertebrate-head-evolution
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[researchers_name] => YASUOKA, Yuuri (安岡有理)
[researchers_position] => Center for Integrative Medical Sciences, RIKEN, Japan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/Gene-.png
[researchers_profile] => https://www.researchgate.net/profile/Yuuri-Yasuoka-2
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[research_footprints] => Lim1; xenopus laevis; cephalochordate; cis-regulatory module; genomics; branchiostoma; untranslated region; vertebrate; Williams-beuren syndrome; chordin; spemann-mangold organizer; gene regulatory network
[graphic_abstract] =>
[video] =>
[the_novelty] => Gene regulatory networks specific to vertebrates illustrate that rearrangement of cis-regulatory modules contributes to the evolution of genetic control for vertebrate development. In this study, researchers compared cis-regulatory modules of vertebrate organizer genes between the amphioxus (Branchiostoma) and the frog (Xenopus) model to understand the evolution of vertebrate head development. In summary, it was found that the goosecoid gene supresses the trunk genes in the vertebrate’s head, which results in the evolution of the vertebrate head with anteriorly enlarged brain. Based on the findings, a model was proposed that the vertebrate goosecoid gene acquired the cis-regulatory module to be activated continuously in the anterior mesoderm of the vertebrate lineage. However, the model should be tested in the future by assays for potential DNA sequence elements using amphioxus models as previously done by other researchers in the genetic control field.
[the_background] => Based on gene expression patterns and neuroanatomy, the rostral part of amphioxus central nervous system is postulated to be homologous to that of vertebrates, suggesting that the vertebrate brain was acquired on a foundation already present in the ancestral chordate, instead of through addition of a new part anterior to the notochord. Recent arguments strongly go against the “new head” theory, where the neural crest and neurogenic placodes are unique to vertebrates, and most of the vertebrate forebrain are neomorphic structures. To address this, research focused on head organizer genes in vertebrates, otx2, lim1/lhx1, goosecoid, and chordin, by comparing their gene regulatory networks during head formation in Branchiostoma and Xenopus to further evaluate how the chordate head evolved.
[the_sdg_impact] => A 2019 report by the United Nations highlighted that around 1 million animal and plant species are now threatened with extinction, many within decades. The findings of the report showed a decline of 20% in the average abundance of native species in most major land-based habitats, more than 40% of amphibian species, almost 33% of reef-forming corals and more than a third of all marine mammals. As presented in this study, an in-depth understanding of the genetic make-up of animals would encourage more innovative conservation and protection efforts to be implemented. Ultimately, the outcome aligns well with UN SDG 14: Life below water for species like amphioxus and SDG 15: Life on Land when the technique is applied for other organisms.
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0143-1
[main_image] => https://iesresearch.solutions/wp-content/uploads/2021/05/Gene-1.jpg
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[publication_title] => Evolution of cis-regulatory modules for the head organizer gene goosecoid in chordates: comparisons between Branchiostoma and Xenopus
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => August 2019
[subject] => Zoology; Biology
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[post_date] => 2021-05-16 19:29:59
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[post_title] => Recapitulation Pattern in Chromatin Accessibility During Vertebrate Embryogenesis
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[researchers_name] => UESAKA, Masahiro (上坂将弘)
[researchers_position] => Center for Biosystems Dynamics Research, RIKEN, Japan
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[researchers_profile] => https://www.researchgate.net/profile/Masahiro-Uesaka
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[research_footprints] => Recapitulation; gene expression; embryogenesis; gallus gallus; C. elegans; parallelism; expression profile; ATAC-seq; regulatory element; developmental stage
[graphic_abstract] =>
[video] =>
[the_novelty] => This study provided molecular-level evidence that the evolutionarily newer genomic regions become more accessible sequentially at later developmental stages of the embryo. Three specimens from vertebrate species were used, namely the mouse, chicken, and medaka embryos, to map out accessible chromatin regions (ACRs). Observations proved that ATAC-seq (an assay for transposase-accessible chromatin using sequencing) used to mark active regulatory regions provided a reliable accessible chromatin landscape and clear estimation of chromatin accessibility at different development stages of whole-embryo. The outcome showed maximum ACRs signals with younger evolutionary ages emerging at later developmental stages; thus, confirming a recapitulation pattern in chromatin accessibility at later stages in the mid-to-late embryogenesis of the vertebrates.
[the_background] => Recapitulation is a hypothetical concept that assumes animal development proceeds along its own evolutionary history, sequentially developing from more ancestral features to more derived ones. Although this concept predicts an evolutionary tendency of animal development, the recent transcriptomic studies have not supported the recapitulation throughout embryogenesis. They showed that the mid-embryonic period, rather than the earliest one, is the most ancestral, or most evolutionarily conserved. Nonetheless, this mid-embryonic conservation does not rule out the possibility that embryogenesis after the mid-embryonic period would still show the recapitulation pattern. Therefore, this study tests the possibility by looking into active gene regulatory regions throughout the embryonic development of selected vertebrate species.
[the_sdg_impact] => In-depth knowledge on animal evolution and development in terms of genes and morphology is key to understanding the survival and adaptability behaviors of the organism. The findings of this study contribute to the existing theories and hypotheses about embryonic development and the similarity with its ancestral evolution patterns. The information gathered could benefit conservation efforts both for aquatic and terrestrial animals, genetic modification of poultry animals, and many more (UNSDG14: Life below water and UNSDG15: Life on land).
[article_url] => https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-019-0148-9
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[publication_title] => Recapitulation-like developmental transitions of chromatin accessibility in vertebrates
[journal_title] => Zoological Letters
[publisher] => BMC
[year] => November 2019
[subject] => Zoology; Biology
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[post_date] => 2021-05-05 14:27:00
[post_date_gmt] => 2021-05-05 06:27:00
[post_content] =>
[post_title] => A Climate-based Dengue Forecast Model
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[researchers_name] => CHUANG, Ting-Wu (莊定武)
[researchers_position] => Department of Molecular Parasitology and Tropical Diseases, Taipei Medical University, Taiwan
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[research_footprints] => multivariate ENSO index; aedes aegypti; diurnal temperature range; autocorrelation function; antibody-dependent enhancement; extrinsic incubation period; partial autocorrelation function; Akaike Information Criterion; sea surface temperature; dengue fever; el nino southern oscillation
[graphic_abstract] =>
[video] =>
[the_novelty] => To establish a better dengue early warning system, efforts have led Taiwanese epidemiologists to develop a dengue forecasting model using climate parameters. The local and regional weekly minimum temperature has been identified as a reliable indicator for predicting disease transmission. In Southern Taiwan, Kaohsiung City and Tainan City are among the two major dengue hotspots. Analysis of the reported dengue cases and climatic conditions of these hotspots showed that temperatures higher than 23˚C is optimal for mosquito development and virus propagation. The effects are predicted to last up to 10-15 weeks. Moreover, the study also looked into the influence of climate variations caused by El Nino-Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) on dengue transmission. As a result, it is suggested to consider the effects of seasonal climate phenomena as part of dengue incidence forecasting. By extension, a similar climate-based forecasting model could be applied to predict the risks of other vector-borne disease transmissions such as Zika and Chikungunya.
[the_background] => Existing dengue control prevention and management are only initiated upon receiving reports of locally acquired human cases. Thus, making it a step too late in controlling the vector propagation and virus transmission from the very beginning. A number of past studies have associated factors such as temperature, relative humidity, and precipitation with dengue transmission. However, there has been no firm prediction model available to give out early warning alerts. Alike previous literature, this study intends to further analyze the influence of climate variability on the disease transmission pattern. The findings are to be used to develop a dengue forecast model effective for early warnings, disease control and preventive measures.
[the_sdg_impact] => In recent decades, the rate of dengue infection worldwide has increased significantly, and around 100-400 million infections are reported each year, as documented by WHO in 2020. Implementing improved outbreak prediction and detection through coordinated epidemiological and entomological surveillance is among the few ways to effectively reduce dengue morbidity. The climate-based dengue forecast model developed in this study allows public health authorities and policymakers to initiate timely preventive measures to reduce the rate of dengue infection as well as prevent a higher death toll. Essentially, the development of such a disease forecast model would contribute towards the realization of UNSDG 3: Good Health and Well-Being, which aims to reduce premature mortality from non-communicable diseases through prevention and treatment. Likewise, the contribution of the tool is also to strengthen resilience and adaptive capacity to climate-related hazards, not just in Taiwan but also other countries facing similar threats. This, in turn, aids the fulfilling of some crucial targets of the United Nation’s Sustainable Development Goals 13 (Climate Action) and 17 (Partnerships for the Goals).
[article_url] => https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178698
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[publication_title] => Effects of local and regional climatic fluctuations on dengue outbreaks in southern Taiwan
[journal_title] => PLOS One
[publisher] => PLOS
[year] => June 2017
[subject] => Molecular Parasitology; Tropical Diseases; Dengue
)
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[post_date] => 2021-05-03 10:31:41
[post_date_gmt] => 2021-05-03 02:31:41
[post_content] =>
[post_title] => Adoption of Mobile Shopping in Developing Countries
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[researchers_name] => PHONG, Nguyen Dong
[researchers_position] => President of UEH, University of Economics Ho Chi Minh City, Vietnam
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[researchers_name_2] => KHOI, Nguyen Huu
[researchers_position_2] => Economics Faculty, Nha Trang University, Vietnam
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[research_footprints] => predictive power; theory of reasoned action; structural equation model; trust; effect size; confirmatory factor analysis; mobile shopping; composite reliability; perceived risk; self-efficacy
[graphic_abstract] =>
[video] =>
[the_novelty] => This study proposed a comprehensive theoretical model by integrating additional variables into the theory of reasoned action (TRA) to understand consumer intention in adopting mobile shopping. Consistent with past literature, TRA served as a good predictive model in understanding the mobile shopping adoption among people of Vietnam. By integrating perceptions of promotion and barrier factors, the study increased the strength of TRA from 19% to 61% in terms of explaining the intention of Vietnamese consumers in adopting mobile shopping. The promotion factors taken into account in building this framework were attitude, norm, self-efficacy, and trust, which showed positive influence on mobile shopping adoption behavior. Perceived risk and cost are among the barriers that holds consumer back from using mobile technologies when shopping. Overall, the outcome of this study is beneficial for business managers and marketers to understand customer drive and concerns and better cater their mobile business strategies and investments.
[the_background] => Platforms such as Amazon.com and ebay have altered the way people shopping for almost 3 decades by bringing it online. In recent years, mobile shopping has become a trend mainly due to the mobile technology advancement and convenience. With that, many researchers have looked into the adoption of this mode of shopping through the lenses of technological driving factors which are mostly centered in developed countries. In developing countries like Vietnam, the technological infrastructure for electronic and mobile shopping are yet to mature up to the extend. Moreover, there are a number of cultural norms that comes into play when consumers consider adopting mobile shopping. Therefore, this study aims to explore and understand how and why Vietnamese consumers decide to use mobile shopping. Hopefully, these findings could contribute to the structuring of appropriate strategies that supports mobile shopping services either from the business perspective or policymaking.
[the_sdg_impact] => The penetration rate of e-commerce in developing countries can be said as slow due to multiple factors, mainly in terms of infrastructure availability. Unlike developed countries, cultural norms and lack of awareness or understanding towards digital platforms can be a huge deal-breaker when consumers in developing countries consider adopting mobile app based services such as mobile shopping or even mobile banking, telehealth and online learning. Hence, the proposed framework in this study allows business owners and policymakers to better understand consumer concerns. This, as intended in UNSDG 9: Industry, innovation and infrastructure, promotes the development of quality, reliable, sustainable and resilient infrastructure to support economic development with a focus on affordable and equitable access for all.
[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-05-2018-0012/full/html
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[publication_title] => Factors affecting mobile shopping: a Vietnamese perspective
[journal_title] => Journal of Asian Business and Economic Studies
[publisher] => Emerald Publishing
[year] => September 2018
[subject] => Business; Economics; Marketing
)
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[post_date] => 2021-05-02 19:47:33
[post_date_gmt] => 2021-05-02 11:47:33
[post_content] =>
[post_title] => A Guide to Improve Risk Disclosure Compliance among Financial Institutions in Developing Countries
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[researchers_name] => NKUUTU, Geofrey
[researchers_position] => Management Science, Makerere University Business School, Uganda
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/geofrey.png
[researchers_profile] => https://www.researchgate.net/profile/Nkuutu-Geofrey
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[researchers_name_2] => NTAYI, Joseph Mpeera
[researchers_position_2] => Procurement and Logistics, Makerere University Business School, Uganda
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[researchers_profile_2] => https://www.researchgate.net/profile/Joseph-Ntayi
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[research_footprints] => structural equation; corporate governance; Uganda; International Financial Reporting Standards; empirical evidence; financial institution
[graphic_abstract] =>
[video] =>
[the_novelty] => For the first time, this study provides a closer look on how the board governance quality (BGQ) mechanism of financial institutions can impact the risk disclosure compliance (RDC) in Uganda. The evidence collected from financial statement analysis and surveys showed that the overall RDC level in Ugandan financial institutions is low, thus, suggesting a weak BGQ in place. Among the factors identified to have a strong influence on RDC levels in the financial institutions are ownership type, firm size, and board size. In order to enhance the transparency levels in these institutions, especially in terms of risk communication, governance board activity, independence, communication, and expertise should be improved. The findings of this study could serve as a useful guideline for policymakers to improve risk information regulation and quality in the given country.
[the_background] => Transparency in disclosing risk information has huge implications, one of which is allowing investors to assess market returns and risk profiles prior to making essential financial decisions. Having said that, there are limited literature available that provides a clearer picture of such risk information management practices in developing countries like Uganda. Furthermore, an analysis on the Ugandan RDC suggested poor compliances with several of the country’s main governance board of the financial institutions. Therefore, this study aims to understand the BGQ mechanisms of Ugandan financial institutions in influencing RDC so that the policymakers could improve the existing board governance framework and policy structure.
[the_sdg_impact] => In the chase towards sustainable finance, there are a number of indicators and standards to follow, such as ESG, SDG, Green Finance, etc. To fulfil these indicators, bank and financial institutions are required to develop and implement new frameworks and regulations. In addition, it is even more crucial for financial institutions to practice transparency when communicating risks and complying to the set rules. Therefore, in line with the notion of developing an effective, accountable and transparent institutions as suggested in UNSDG 16: Peace, justice and strong institutions, policymakers of developing countries could utilize the findings of this study to enhance respective financial institutions and governance board quality.
[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-04-2020-0036/full/html
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[journal_title] => Journal of Asian Business and Economic Studies
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[year] => October 2020
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[post_date] => 2021-05-02 19:29:00
[post_date_gmt] => 2021-05-02 11:29:00
[post_content] =>
[post_title] => Unique Employment and Investment Practices to Drive Manufacturing Industry Growth
[post_excerpt] =>
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[researchers_name] => KIM, Sangho
[researchers_position] => College of International Management, Ritsumeikan Asia Pacific University, Japan
[researchers_photo] => https://iesresearch.solutions/wp-content/uploads/2021/05/kim-sang.png
[researchers_profile] => https://www.researchgate.net/profile/Sangho-Kim-3
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[research_footprints] => information technology; short run; production; long run; dynamic structure; manufacturing industry
[graphic_abstract] =>
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[the_novelty] => This research provides better knowledge of the unique dynamic structure of the Japanese manufacturing industry by looking at the production structure and industrial policies. When the dynamic production structure is analyzed using the adjustment cost approach, it is proved that the adjustment coefficients for labor and capital are very low, about 0.2% annually only. Such is the consequence of lifetime employment contract and slow and carefully considered investment decision making. The results of the research also emphasized the influence of time horizon on short term output supply and factor demand elasticities, thus, urging policymakers to consider it as a factor to assess policy impacts accurately.
[the_background] => Japanese manufacturing industry, known for its continuous and relentless transformation, attracted the attention of many industrial leaders. Their unique practices in perfecting their products over the long haul includes a distinguished employment term and cautious investment strategy. Nevertheless, the industrial policies drafted by the government are also drivers of the manufacturing industry growth. Since there is lack of literature evidence on the implications of these practices, this study aims to explain the production structure and manufacturing investment patterns of the Japanese industry as well as the policies that complement the practices.
[the_sdg_impact] => One of the targets of the 8th United Nations’ Sustainable Development Goal is to achieve higher levels of economic productivity through diversification, technological upgrading and innovation, including through a focus on high-value added and labour-intensive sectors. In Japan, the manufacturing industry is among the capital- and skilled labor-intensive sectors which has constantly gone through transformation to cope with economic setbacks and evolution. In order to continue such growth and to improve the decision-making process of the industrial owners as well as the government, it is crucial for the findings of this research to be considered. With that, better employment and investment efforts could be adopted. Apart from that, other countries could also learn the best practices to improve their respective manufacturing industries and economic productivity.
[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-12-2019-0123/full/html
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[publication_title] => Dynamic factor demand in the Japanese manufacturing industry
[journal_title] => Journal of Asian Business and Economic Studies
[publisher] => Emerald Publishing
[year] => February 2020
[subject] => Business; Economics; Finance
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[post_date] => 2021-05-02 19:14:47
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[post_content] =>
[post_title] => Taxation and Stock Market Index Volatility
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[post_status] => publish
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[post_name] => tax-reformation-and-stock-market-index-volatility
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[researchers_name] => HARON, Razali
[researchers_position] => IIUM Institute of Islamic Banking and Finance, International Islamic University Malaysia, Malaysia
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[researchers_profile] => https://www.researchgate.net/profile/Razali-Haron-2
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[researchers_name_2] => AYOJIMI, Salami Mansurat
[researchers_position_2] => Kulliyyah of Economics and Management Sciences, International Islamic University Malaysia, Malaysia
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[researchers_profile_2] => https://www.researchgate.net/profile/Monsurat-Salami-2
[researchers_second_profile_2] => https://orcid.org/0000-0001-5314-8971
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[original_article_reference] =>
[research_footprints] => consumer price index; producer price index; European Union; federal fund rate; future market; Schwarz information criterion; arbitrage pricing theory; nonfarm payroll employment; unemployment rate; Akaike information; criterion; GARCH; market volatility; Federal Open Market Committee
[graphic_abstract] =>
[video] =>
[the_novelty] => This study analyzed the impact of fiscal reform initiatives on stock market volatility throughout the pre-, during, and post-announcement processes. By taking the scenario of Good and Service Tax (GST) implementation announced by the Malaysian government in 2014, the study proved that macroeconomic news announcement increases market volatility. This is especially true during and after the announcement of GST implementation; thus, contradicting past literature that scheduled macroeconomic news reduces market volatility. In other terms, it shows that the Malaysian government’s effort on educating its people through GST awareness programs was inefficient in preparing its people for the change. The attempt to understand the effect of GST on Malaysian stock index return volatility while controlling factors such as PPI, CPI, and UNEMPR, to the best of the researchers’ knowledge, is novel and contributes significantly to the existing literature on market volatility triggers.
[the_background] => As Malaysians can recall, the announcement of a 6 percent GST tax to be imposed for about 1200 selected items took the nation by surprise and triggered a stream of public debates, concerns, and uncertainties. A major shift in buying behaviors for items such as cars, furniture, and electrical appliances was noticed following the announcement period before the implementation. At the same time, the Malaysian government has been actively introducing GST awareness programs to educate the public on the tax implementation implications. Following such unsettling event, this research intends to understand how the market would react to the shocks and concerns revolving around this new tax reform. By understanding the expectation of the market, the government and policymakers could make better decisions when it comes to planning the nation’s tax reform.
[the_sdg_impact] => A recent article by EY (2020) quotes that “a comprehensive and well-thought-out tax reform can help a nation boost its economy which growing its tax revenue in the long run.” The OECD report on Tax and Economic Growth stated that the effects of tax levels and tax structures on agents’ economic behavior are likely to be reflected in overall living standards. Therefore, the findings of this study provide insights on public reactions towards tax reforms and their impact on market volatility which would benefit the government in future fiscal reform initiatives, as well as to understand the people’s pain point. In extension, this contributes to the efforts in promoting inclusive and sustainable economic growth as envisioned in UNSDG 8: Decent work and economic growth.
[article_url] => https://www.emerald.com/insight/content/doi/10.1108/JABES-06-2018-0027/full/html
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[doi] => https://doi.org/10.1108/JABES-06-2018-0027
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[publication_title] => The impact of GST implementation on the Malaysian stock market index volatility: An empirical approach
[journal_title] => Journal of Asian Business and Economic Studies
[publisher] => Emerald Publishing
[year] => December 2018
[subject] => Business; Economics; Finance
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[141] => WP_Post Object
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