Post Views: 134 The Chemistry We’ve Been Missing: LC–MS-based Metabolomics Strategies to Reveal Hidden Health Signals Inside our bodies, and inside fruits and medicinal plants, thousands of tiny molecules reflect what is happening in real time. These molecules, called metabolites, can reveal early signs of cancer, infection, mental health imbalance, or nutritional function. However, many of…
Post Views: 1,173 Blocking a Tumor’s Protective Signal Strengthens Immune Defense Triple-negative breast cancer (TNBC) is among the most challenging forms of breast cancer to treat. Unlike other subtypes, it lacks hormone receptors and HER2 expression, leaving fewer targeted therapy options available. Although immunotherapy has shown promise in some patients, many TNBC tumors create a…
Post Views: 1,139 Ether-Lipid Accumulation Linked to Faster Progression of Liver Cancer Liver cancer, particularly hepatocellular carcinoma (HCC), is often associated with chronic metabolic stress, including fatty liver disease and long-term inflammation. As researchers continue to uncover how cancer cells rewire their metabolism to survive and spread, attention has increasingly turned toward lipids, molecules once considered passive…
Post Views: 2,441 Seeing Disease Earlier, Faster, and More Clearly Modern medicine produces vast amounts of data, yet many clinical decisions are still made only after disease becomes visible or irreversible. Prof. Zhang Kang’s research team at the Macau University of Science and Technology is working toward a different paradigm: identifying meaningful biological change earlier, interpreting complex…
Post Views: 848 A Newly Identified DNA Repair Switch Drives Resistance to PARP Inhibitors in Breast Cancer Targeted cancer therapies are designed to exploit specific weaknesses in tumor cells. One such treatment, PARP inhibitors, has transformed care for patients with breast cancers carrying BRCA mutations. These drugs work by blocking a DNA repair protein called…
Post Views: 588 Lithium-Enhanced Bone Scaffold Promotes Immune-Guided Bone Regeneration Repairing damaged bone is not simply a matter of filling a structural gap. Successful bone healing depends on a carefully orchestrated interaction between immune cells, blood vessels, and bone-forming cells. When bone is injured, immune cells such as macrophages arrive first. Initially, they trigger inflammation…
Post Views: 1,216 Engineered Hydrogel Enhances Diabetic Wound Healing by Modulating Immune Response Chronic wounds are among the most challenging complications faced by people living with diabetes. Unlike normal injuries that heal in a predictable sequence, diabetic wounds often remain trapped in prolonged inflammation. Poor blood circulation, oxidative stress, and impaired collagen formation prevent proper…
Post Views: 1,238 Ginkgolide B Linked to Longer and Healthier Lifespan in Aging Mice As life expectancy rises worldwide, a pressing question arises: how can we ensure that longer lives are also healthier ones? Aging is often accompanied by gradual muscle weakness, metabolic imbalance, chronic low-grade inflammation, and increased cancer risk. Extending lifespan alone is no longer…
Post Views: 821 Why Medicine Often Fails—and How the Body’s Own Delivery System Could Change That When new medicines are developed, the focus is usually on making them stronger or more effective. But in real life, many promising treatments fail for a different reason: they never reach the right cells in the body. Instead, they…
Post Views: 3,044 From Natural Products to Drug Candidates: A Two-Way Research Model for Future Therapies in Cardiovascular, Arthritis, and Cancer Diseases Over the past two decades, under the leadership of Professor Yi-Zhun Zhu, researchers at the Macau University of Science and Technology have been focusing on a distinctive bidirectional research model for small molecule…
